@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3XXZ4: (2018-01-06 )
MAQHVFIVGLGLIGASMALCIRQTNPELIVVGWDSQSKTREQAVEQQIVDYVASDFETGAEQADVILLAVPVRTTLAYLDVLERINLSDHVIITDVSSTKQQVVTSAEQKNLRFVGGHPMAGSHKSGIQAADAKLFENAYYIFTPLEKTKKDVEKLQELFCGTKAKYVTLTAREHDRITGMLSHFPHILAAGLVNQAEQFNQEYPRAKQLAAGGFRDITRIASSDPVMWTDILLSNKQILLERLADWQQEMTQIAEWIMTENQSEIFSFFNRAKESRDQLPVHKQGAIPAFFDLFIDVPDEPGVIAEVTGLIGKAGVSLINLKIQETREDILGILQISFKNQQDLLQAKRIIMSNTSYHCWIK
Atome Classification :
(24 SA)
.........10........20......--..--30........40........50.......-.60-........70........80...-.-....90........100......----.----110.......120.......130.......140......-.-150.-.......160-.........-170.......180.......190.......200.-.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MA
Q
H
V
F
I
V
G
L
G
L
I
G
A
S
M
A
L
C
I
RQTNP
E
--
L
I
--
V
V
GWDSQ
S
K
T
R
E
Q
A
V
E
Q
Q
I
V
D
Y
V
A
S
D
F
ET-GAE-QA
D
V
I
L
L
AV
P
V
R
T
T
L
A
Y
L
D
V
L
E
R-I-NLSD
H
V
I
I
TDVSS
T
K
Q
Q
V
V
T
SAE----Q----K
N
L
R
F
VGGHPMAGSHKSGI
Q
A
A
D
A
K
L
FE
N
A
Y
Y
I
FT
P
L
E
K
-
T
-
K
-
K
D
-
V
E
K
L
Q
E
L
F---CGTK
A
K
Y
V
T
-
L
TARE
H
D
R
I
T
G
M
L
S
H
F
P
H
I
L
A
A
G
L
V
N
Q
A
E
Q
F
-
N
Q
-EYP
R
A
K
Q
L
AAG
G
F
R
D
I
T
R
IASSD
P
V
M
W
T
D
I
LLS
N
K
Q
I
L
L
E
R
L
A
D
W
Q
Q
E
M
T
Q
I
A
E
W
I
MTE
N
Q
S
E
I
F
S
F
F
N
R
A
KESRDQLPVHKQGA
I
P
A
F
F
D
L
F
I
DVPDEP
G
V
I
A
E
V
T
G
L
I
G
KAG
V
S
L
I
N
L
K
I
Q
E
T
R
E
D
I
L
G
I
L
Q
ISFK
N
Q
Q
D
L
L
Q
A
K
R
I
IMSNT
S
Y
H
C
W
IK
22
PsiBlast_CBE
83.04
44%
-55
- C2 -
-
5UYY
2
?
C:
[16-367]
M
R
K
K
V
V
L
I
G
T
G
L
I
G
G
S
L
A
L
A
I
K
K
D
H
-
D
--
V
T
--
I
T
G
Y
D
I
F
Q
E
Q
V
E
R
A
K
E
L
H
V
V
D
E
I
A
V
D
L
Q
H
-
A
C
E
-
E
A
H
L
I
V
F
A
S
P
V
E
E
T
K
K
L
L
H
K
L
A
S
-
F
-
H
L
R
E
D
V
I
V
T
D
V
G
S
T
K
G
S
I
M
N
E
A
E
ALF-
S
----
K
E
I
S
F
I
G
G
H
P
M
A
G
S
H
K
T
G
V
E
S
A
K
A
H
L
F
E
N
A
F
Y
I
L
T
P
M
H
H
-
V
-
P
-
N
E
H
V
E
E
L
K
D
W
L
---
K
G
T
G
S
H
F
L
V
-
L
N
T
E
E
H
D
Y
V
T
G
I
V
S
H
F
P
H
L
I
A
A
G
L
V
K
Q
V
E
K
H
-
A
G
-
D
N
P
L
I
H
Q
L
A
A
G
G
F
K
D
I
T
R
I
A
S
S
S
P
K
M
W
S
D
I
V
K
Q
N
R
E
H
L
M
V
L
L
K
E
W
I
S
E
M
E
D
L
Y
D
T
V
S
S
G
D
A
G
E
I
Q
N
Y
F
A
D
A
K
E
Y
R
D
S
L
P
V
R
K
R
G
A
I
P
A
Y
H
D
L
Y
V
D
V
L
D
K
V
G
A
L
A
H
V
T
S
I
L
A
R
E
E
I
S
I
T
N
L
Q
I
L
E
A
R
E
G
L
L
G
V
L
R
I
S
F
Q
R
E
E
D
R
M
K
A
K
--------------
2
PsiBlast_PDB
81.48
44%
-56
- C2 -
-
5UYY
2
?
A:
[16-367]
M
R
K
K
V
V
L
I
G
T
G
L
I
G
G
S
L
A
L
A
I
K
K
D
H
-
D
--
V
T
--
I
T
G
Y
D
I
F
Q
E
Q
V
E
R
A
K
E
L
H
V
V
D
E
I
A
V
D
L
Q
H
-
A
C
E
-
E
A
H
L
I
V
F
A
S
P
V
E
E
T
K
K
L
L
H
K
L
A
S
-
F
-
H
L
R
E
D
V
I
V
T
D
V
G
S
T
K
G
S
I
M
N
E
A
E
A
L
F-
S
----
K
E
I
S
F
I
G
G
H
P
M
A
G
S
H
K
T
G
V
E
S
A
K
A
H
L
F
E
N
A
F
Y
I
L
T
P
M
H
H
-
V
-
P
-
N
E
H
V
E
E
L
K
D
W
L
---
K
G
T
G
S
H
F
L
V
-
L
N
T
E
E
H
D
Y
V
T
G
I
V
S
H
F
P
H
L
I
A
A
G
L
V
K
Q
V
E
K
H
-
A
G
-
D
N
P
L
I
H
Q
L
A
A
G
G
F
K
D
I
T
R
I
A
S
S
S
P
K
M
W
S
D
I
V
K
Q
N
R
E
H
L
M
V
L
L
K
E
W
I
S
E
M
E
D
L
Y
D
T
V
S
S
G
D
A
G
E
I
Q
N
Y
F
A
D
A
K
E
Y
R
D
S
L
P
V
R
K
R
G
A
I
P
A
Y
H
D
L
Y
V
D
V
L
D
K
V
G
A
L
A
H
V
T
S
I
L
A
R
E
E
I
S
I
T
N
L
Q
I
L
E
A
R
E
G
L
L
G
V
L
R
I
S
F
Q
R
E
E
D
R
M
K
A
K
--------------
1
PsiBlast_PDB
81.34
44%
-54
- C2 -
-
5USC
2
?
A:
[17-367]
-
R
K
K
V
V
L
I
G
T
G
L
I
G
G
S
L
A
L
A
I
K
K
D
H
-
D
--
V
T
--
I
T
G
Y
D
I
F
Q
E
Q
V
E
R
A
K
E
L
H
V
V
D
E
I
A
V
D
L
Q
H
-
A
C
E
-
E
A
H
L
I
V
F
A
S
P
V
E
E
T
K
K
L
L
H
K
L
A
S
-
F
-
H
L
R
E
D
V
I
V
T
D
V
G
S
T
K
G
S
I
M
N
E
A
E
A
L
F-
S
----
K
E
I
S
F
I
G
G
H
P
M
A
G
S
H
K
T
G
V
E
S
A
K
A
H
L
F
E
N
A
F
Y
I
L
T
P
M
H
H
-
V
-
P
-
N
E
H
V
E
E
L
K
D
W
L
---
K
G
T
G
S
H
F
L
V
-
L
N
T
E
E
H
D
Y
V
T
G
I
V
S
H
F
P
H
L
I
A
A
G
L
V
K
Q
V
E
K
H
-
A
G
-
D
N
P
L
I
H
Q
L
A
A
G
G
F
K
D
I
T
R
I
A
S
S
S
P
K
M
W
S
D
I
V
K
Q
N
R
E
H
L
M
V
L
L
K
E
W
I
S
E
M
E
D
L
Y
D
T
V
S
S
G
D
A
G
E
I
Q
N
Y
F
A
D
A
K
E
Y
R
D
S
L
P
V
R
K
R
G
A
I
P
A
Y
H
D
L
Y
V
D
V
L
D
K
V
G
A
L
A
H
V
T
S
I
L
A
R
E
E
I
S
I
T
N
L
Q
I
L
E
A
R
E
G
L
L
G
V
L
R
I
S
F
Q
R
E
E
D
R
M
K
A
K
--------------
24
PsiBlast_CBE
80.62
44%
-53
- C2 -
-
5USC
3
?
B:
[17-367]
-
R
K
K
V
V
L
I
G
T
G
L
I
G
G
S
L
A
L
A
I
K
K
D
H
-
D
--
V
T
--
I
T
G
Y
D
I
F
Q
E
Q
V
E
R
A
K
E
L
H
V
V
D
E
I
A
V
D
L
Q
H
-
A
C
E
-
E
A
H
L
I
V
F
A
S
P
V
E
E
T
K
K
L
L
H
K
L
A
S
-
F
-
H
L
R
E
D
V
I
V
T
D
V
G
S
T
K
G
S
I
M
N
E
A
E
ALF-
S
----
K
E
I
S
F
I
G
G
H
P
M
A
G
S
H
K
T
G
V
E
S
A
K
A
H
L
F
E
N
A
F
Y
I
L
T
P
M
H
H
-
V
-
P
-
N
E
H
V
E
E
L
K
D
W
L
---
K
G
T
G
S
H
F
L
V
-
L
N
T
E
E
H
D
Y
V
T
G
I
V
S
H
F
P
H
L
I
A
A
G
L
V
K
Q
V
E
K
H
-
A
G
-
D
N
P
L
I
H
Q
L
A
A
G
G
F
K
D
I
T
R
I
A
S
S
S
P
K
M
W
S
D
I
V
K
Q
N
R
E
H
L
M
V
L
L
K
E
W
I
S
E
M
E
D
L
Y
D
T
V
S
S
G
D
A
G
E
I
Q
N
Y
F
A
D
A
K
E
Y
R
D
S
L
P
V
R
K
R
G
A
I
P
A
Y
H
D
L
Y
V
D
V
L
D
K
V
G
A
L
A
H
V
T
S
I
L
A
R
E
E
I
S
I
T
N
L
Q
I
L
E
A
R
E
G
L
L
G
V
L
R
I
S
F
Q
R
E
E
D
R
M
K
A
K
--------------
46
HHSearch
80.52
43%
-37
- C2 -
-
5UYY
2
?
C:
[17-379]
-
R
K
K
V
V
L
I
G
T
G
L
I
G
G
S
L
A
L
A
I
K
K
D
-
H
D
--
V
T
--
I
T
G
Y
D
I
F
Q
E
Q
V
E
R
A
K
E
L
H
V
V
D
E
I
A
V
D
L
Q
H
-
A
C
E
-
E
A
H
L
I
V
F
A
S
P
V
E
E
T
K
K
L
L
H
K
L
A
S
F
H
-
L
-
R
E
D
V
I
V
T
D
V
G
S
T
K
G
S
I
M
N
E
A
E
----
A
LFS-
K
E
I
S
F
I
G
G
H
P
M
A
G
S
H
K
T
G
V
E
S
A
K
A
H
L
F
E
N
A
F
Y
I
L
T
P
M
H
H
-
V
-
P
N
E
H
-
V
E
E
L
K
D
W
L
---
K
G
T
G
S
H
F
L
V
-
L
N
T
E
E
H
D
Y
V
T
G
I
V
S
H
F
P
H
L
I
A
A
G
L
V
K
Q
V
E
K
H
-
A
G
-
D
N
P
L
I
H
Q
L
A
A
G
G
F
K
D
I
T
R
I
A
S
S
S
P
K
M
W
S
D
I
V
K
Q
N
R
E
H
L
M
V
L
L
K
E
W
I
S
E
M
E
D
L
Y
D
T
V
S
S
G
D
A
G
E
I
Q
N
Y
F
A
D
A
K
E
Y
R
D
S
L
P
V
R
K
R
G
A
I
P
A
Y
H
D
L
Y
V
D
V
L
D
K
V
G
A
L
A
H
V
T
S
I
L
A
R
E
E
I
S
I
T
N
L
Q
I
L
E
A
R
E
G
L
L
G
V
L
R
I
S
F
Q
R
E
E
D
R
M
K
A
K
L
A
L
G
E
E
K
-
Y
Q
T
Y
E
-
47
HHSearch
79.45
43%
-34
- C2 -
-
5USC
2
?
A:
[17-379]
-
R
K
K
V
V
L
I
G
T
G
L
I
G
G
S
L
A
L
A
I
K
K
D
-
H
D
--
V
T
--
I
T
G
Y
D
I
F
Q
E
Q
V
E
R
A
K
E
L
H
V
V
D
E
I
A
V
D
L
Q
H
-
A
C
E
-
E
A
H
L
I
V
F
A
S
P
V
E
E
T
K
K
L
L
H
K
L
A
S
F
H
-
L
-
R
E
D
V
I
V
T
D
V
G
S
T
K
G
S
I
M
N
E
A
E
----
A
L
FS-
K
E
I
S
F
I
G
G
H
P
M
A
G
S
H
K
T
G
V
E
S
A
K
A
H
L
F
E
N
A
F
Y
I
L
T
P
M
H
H
-
V
-
P
N
E
H
-
V
E
E
L
K
D
W
L
---
K
G
T
G
S
H
F
L
V
-
L
N
T
E
E
H
D
Y
V
T
G
I
V
S
H
F
P
H
L
I
A
A
G
L
V
K
Q
V
E
K
H
-
A
G
-
D
N
P
L
I
H
Q
L
A
A
G
G
F
K
D
I
T
R
I
A
S
S
S
P
K
M
W
S
D
I
V
K
Q
N
R
E
H
L
M
V
L
L
K
E
W
I
S
E
M
E
D
L
Y
D
T
V
S
S
G
D
A
G
E
I
Q
N
Y
F
A
D
A
K
E
Y
R
D
S
L
P
V
R
K
R
G
A
I
P
A
Y
H
D
L
Y
V
D
V
L
D
K
V
G
A
L
A
H
V
T
S
I
L
A
R
E
E
I
S
I
T
N
L
Q
I
L
E
A
R
E
G
L
L
G
V
L
R
I
S
F
Q
R
E
E
D
R
M
K
A
K
L
A
L
G
E
E
K
-
Y
Q
T
Y
E
-
21
PsiBlast_CBE
79.00
44%
-54
- C2 -
-
5UYY
2
?
D:
[17-367]
-
R
K
K
V
V
L
I
G
T
G
L
I
G
G
S
L
A
L
A
I
K
K
D
H
-
D
--
V
T
--
I
T
G
Y
D
I
F
Q
E
Q
V
E
R
A
K
E
L
H
V
V
D
E
I
A
V
D
L
Q
H
-
A
C
E
-
E
A
H
L
I
V
F
A
S
P
V
E
E
T
K
K
L
L
H
K
L
A
S
-
F
-
H
L
R
E
D
V
I
V
T
D
V
G
S
T
K
G
S
I
M
N
E
A
E
ALF-
S
----
K
E
I
S
F
I
G
G
H
P
M
A
G
S
H
K
T
G
V
E
S
A
K
A
H
L
F
E
N
A
F
Y
I
L
T
P
M
H
H
-
V
-
P
-
N
E
H
V
E
E
L
K
D
W
L
---
K
G
T
G
S
H
F
L
V
-
L
N
T
E
E
H
D
Y
V
T
G
I
V
S
H
F
P
H
L
I
A
A
G
L
V
K
Q
V
E
K
H
-
A
G
-
D
N
P
L
I
H
Q
L
A
A
G
G
F
K
D
I
T
R
I
A
S
S
S
P
K
M
W
S
D
I
V
K
Q
N
R
E
H
L
M
V
L
L
K
E
W
I
S
E
M
E
D
L
Y
D
T
V
S
S
G
D
A
G
E
I
Q
N
Y
F
A
D
A
K
E
Y
R
D
S
L
P
V
R
K
R
G
A
I
P
A
Y
H
D
L
Y
V
D
V
L
D
K
V
G
A
L
A
H
V
T
S
I
L
A
R
E
E
I
S
I
T
N
L
Q
I
L
E
A
R
E
G
L
L
G
V
L
R
I
S
F
Q
R
E
E
D
R
M
K
A
K
--------------
23
PsiBlast_CBE
78.65
44%
-53
- C2 -
-
5UYY
2
?
B:
[17-367]
-
R
K
K
V
V
L
I
G
T
G
L
I
G
G
S
L
A
L
A
I
K
K
D
H
-
D
--
V
T
--
I
T
G
Y
D
I
F
Q
E
Q
V
E
R
A
K
E
L
H
V
V
D
E
I
A
V
D
L
Q
H
-
A
C
E
-
E
A
H
L
I
V
F
A
S
P
V
E
E
T
K
K
L
L
H
K
L
A
S
-
F
-
H
L
R
E
D
V
I
V
T
D
V
G
S
T
K
G
S
I
M
N
E
A
E
A
L
F-
S
----
K
E
I
S
F
I
G
G
H
P
M
A
G
S
H
K
T
G
V
E
S
A
K
A
H
L
F
E
N
A
F
Y
I
L
T
P
M
H
H
-
V
-
P
-
N
E
H
V
E
E
L
K
D
W
L
---
K
G
T
G
S
H
F
L
V
-
L
N
T
E
E
H
D
Y
V
T
G
I
V
S
H
F
P
H
L
I
A
A
G
L
V
K
Q
V
E
K
H
-
A
G
-
D
N
P
L
I
H
Q
L
A
A
G
G
F
K
D
I
T
R
I
A
S
S
S
P
K
M
W
S
D
I
V
K
Q
N
R
E
H
L
M
V
L
L
K
E
W
I
S
E
M
E
D
L
Y
D
T
V
S
S
G
D
A
G
E
I
Q
N
Y
F
A
D
A
K
E
Y
R
D
S
L
P
V
R
K
R
G
A
I
P
A
Y
H
D
L
Y
V
D
V
L
D
K
V
G
A
L
A
H
V
T
S
I
L
A
R
E
E
I
S
I
T
N
L
Q
I
L
E
A
R
E
G
L
L
G
V
L
R
I
S
F
Q
R
E
E
D
R
M
K
A
K
--------------
4
PsiBlast_PDB
70.63
44%
-77
- C2 -
-
3B1F
1
?
A:
[9-286]
----
I
Y
I
A
G
L
G
L
I
G
A
S
L
A
L
G
I
K
R
D
H
P
H
--
Y
K
--
I
V
G
Y
N
R
S
D
R
S
R
D
I
A
L
E
R
G
I
V
D
E
A
T
A
D
F
K
V
-
F
A
A
-
L
A
D
V
I
I
L
A
V
P
I
K
K
T
I
D
F
I
K
I
L
A
D
-
L
-
D
L
K
E
D
V
I
I
T
D
A
G
S
T
K
Y
E
I
V
R
A
A
E
Y
Y
LK
D
----
K
P
V
Q
F
V
G
S
H
P
M
A
----
S
G
A
V
A
A
N
V
N
L
F
E
N
A
Y
Y
I
F
S
P
S
C
L
-
T
-
K
-
P
N
T
I
P
A
L
Q
D
L
L
---
S
G
L
H
A
R
Y
V
E
-
I
D
A
A
E
H
D
C
V
T
S
Q
I
S
H
F
P
H
I
I
A
S
S
L
M
K
Q
A
G
D
F
-
S
E
-
S
H
E
M
T
K
H
F
A
A
G
G
F
R
D
M
T
R
I
A
E
S
E
P
G
M
W
T
S
I
L
L
T
N
Q
E
A
V
L
D
R
I
E
N
F
K
Q
R
L
D
E
V
S
N
L
I
K
A
R
D
E
N
A
I
W
A
F
F
N
Q
S
R
Q
I
R
--------------------------------------------------------------------------------------
54
HHSearch
69.22
45%
-50
* C2 *
-
3B1F
1
?
A:
[5-289]
E
E
K
T
I
Y
I
A
G
L
G
L
I
G
A
S
L
A
L
G
I
K
R
D
H
P
H
--
Y
K
--
I
V
G
Y
N
R
S
D
R
S
R
D
I
A
L
E
R
G
I
V
D
E
A
T
A
D
F
K
V
-
F
A
A
-
L
A
D
V
I
I
L
A
V
P
I
K
K
T
I
D
F
I
K
I
L
A
D
-
L
D
L
-
K
E
D
V
I
I
T
D
A
G
S
T
K
Y
E
I
V
R
A
A
E
----
Y
Y
LKD
K
P
V
Q
F
V
G
S
H
P
M
A
----
S
G
A
V
A
A
N
V
N
L
F
E
N
A
Y
Y
I
F
S
P
S
C
L
-
T
K
P
-
N
T
-
I
P
A
L
Q
D
L
L
---
S
G
L
H
A
R
Y
V
E
-
I
D
A
A
E
H
D
C
V
T
S
Q
I
S
H
F
P
H
I
I
A
S
S
L
M
K
Q
A
G
D
F
-
S
E
-
S
H
E
M
T
K
H
F
A
A
G
G
F
R
D
M
T
R
I
A
E
S
E
P
G
M
W
T
S
I
L
L
T
N
Q
E
A
V
L
D
R
I
E
N
F
K
Q
R
L
D
E
V
S
N
L
I
K
A
R
D
E
N
A
I
W
A
F
F
N
Q
S
R
Q
I
R
K
N
M
-----------------------------------------------------------------------------------
3
PsiBlast_PDB
68.33
46%
-60
- C2 -
-
3DZB
-
?
A:
[6-298]
----
I
Y
I
A
G
L
G
L
I
G
G
S
L
A
L
G
I
K
R
D
H
P
D
--
Y
E
--
I
L
G
Y
N
R
S
D
Y
S
R
N
I
A
L
E
R
G
I
V
D
R
A
T
G
D
F
K
E
-
F
A
P
-
L
A
D
V
I
I
L
A
V
P
I
K
Q
T
M
A
Y
L
K
E
L
A
D
-
L
-
D
L
K
D
N
V
I
I
T
D
A
G
S
T
K
R
E
I
V
E
A
A
E
----
R
Y
LTG
K
N
V
Q
F
V
G
S
H
P
M
A
G
S
------
A
A
D
V
T
L
F
E
N
A
Y
Y
I
F
T
P
T
S
L
-
T
-
K
-
E
T
T
I
P
E
L
K
D
I
L
---
S
G
L
K
S
R
Y
V
E
-
I
D
A
A
E
H
D
R
V
T
S
Q
I
S
H
F
P
H
L
L
A
S
G
L
M
E
Q
A
A
D
Y
-
A
Q
-
A
H
E
M
T
N
H
F
A
A
G
G
F
R
D
M
T
R
I
A
E
S
E
P
G
M
W
A
S
I
L
M
T
N
G
P
A
V
L
D
R
I
E
D
F
K
K
R
L
D
H
V
A
D
L
I
K
A
E
D
E
S
A
I
W
E
F
F
D
N
G
R
K
K
R
K
E
M
E
I
H
K
K
G
G
V
E
S
A
F
-----------------------------------------------------------------------
9
PsiBlast_PDB
61.06
31%
-65
- C2 -
-
4WJI
2
?
A:
[5-283]
--
Q
T
I
A
L
I
G
I
G
L
I
G
S
S
I
A
R
D
I
R
E
K
Q
L
A
--
G
T
--
I
V
V
T
T
R
S
E
A
T
L
K
R
A
G
E
L
G
L
G
D
R
Y
T
L
S
A
A
E
-
A
V
E
-
G
A
D
L
V
V
V
S
V
P
V
G
A
S
G
A
V
A
A
E
I
A
--
A
-
H
L
K
P
G
A
I
V
T
D
V
G
S
T
K
G
S
V
I
A
Q
M
A
----
P
HLP-
K
D
V
H
F
V
P
G
H
P
I
A
G
T
E
H
S
G
P
D
A
G
F
A
G
L
F
R
G
R
W
C
I
L
T
P
P
A
G
-
T
-
D
-
E
E
-
A
V
A
R
L
R
L
F
---
W
E
T
L
G
S
M
V
D
E
M
D
P
K
H
H
D
K
V
L
A
I
V
S
H
L
P
H
I
I
A
Y
N
I
V
G
T
A
D
D
L
-
E
T
V
T
E
S
E
V
I
K
Y
S
A
S
G
F
R
D
F
T
R
L
A
A
S
D
P
T
M
W
R
D
V
C
L
H
N
K
D
A
I
L
E
M
L
A
R
F
S
E
D
L
A
S
L
Q
R
A
I
R
W
G
D
G
D
K
L
F
D
L
F
T
R
T
R
A
I
R
--------------------------------------------------------------------------------------
5
PsiBlast_PDB
59.47
31%
-14
- C2 -
-
3GGG
2
?
D:
[34-313]
--
Q
N
V
L
I
V
G
V
G
F
M
G
G
S
F
A
K
S
L
R
R
S
G
F
K
--
G
K
--
I
Y
G
Y
D
I
N
P
E
S
I
S
K
A
V
D
L
G
I
I
D
E
G
T
T
S
I
A
K
-
V
E
D
F
S
P
D
F
V
M
L
S
S
P
V
R
T
F
R
E
I
A
K
K
L
S
Y
-
I
--
L
S
E
D
A
T
V
T
D
Q
G
S
V
K
G
K
L
V
Y
D
L
E
----
N
I---
L
G
K
R
F
V
G
G
H
P
I
A
G
T
E
K
S
G
V
E
Y
S
L
D
N
L
Y
E
G
K
K
V
I
L
T
P
T
K
K
-
T
-
D
-
K
K
-
R
L
K
L
V
K
R
V
WED
V
G
G
V
V
E
Y
---
M
S
P
E
L
H
D
Y
V
F
G
V
V
S
H
L
P
H
A
V
A
F
A
L
V
D
T
L
I
H
M
-
S
T
-
P
E
V
D
L
F
K
Y
P
G
G
G
F
K
D
F
T
R
I
A
K
S
D
P
I
M
W
R
D
I
F
L
E
N
K
E
N
V
M
K
A
I
E
G
F
E
K
S
L
N
H
L
K
E
L
I
V
R
E
A
E
E
E
L
V
E
Y
L
K
E
V
K
I
K
R
M
E
I
-----------------------------------------------------------------------------------
55
HHSearch
58.98
30%
-8
- C2 -
-
4WJI
2
?
A:
[3-289]
Q
F
Q
T
I
A
L
I
G
I
G
L
I
G
S
S
I
A
R
D
I
R
E
K
--
Q
LA
G
T
--
I
V
V
T
T
R
S
E
A
T
L
K
R
A
G
E
L
G
L
G
D
R
Y
T
L
S
A
A
E
-
A
V
E
-
G
A
D
L
V
V
V
S
V
P
V
G
A
S
G
A
V
A
A
E
I
A
A
-
H
-
L
-
K
P
G
A
I
V
T
D
V
G
S
T
K
G
S
V
I
A
Q
M
A
----
P
HLP-
K
D
V
H
F
V
P
G
H
P
I
A
G
T
E
H
S
G
P
D
A
G
F
A
G
L
F
R
G
R
W
C
I
L
T
P
P
A
G
T
D
-
E
-
E
A
-
V
A
R
L
R
L
F
W
---
E
T
L
G
S
M
V
D
E
-
M
D
P
K
H
H
D
K
V
L
A
I
V
S
H
L
P
H
I
I
A
Y
N
I
V
G
T
A
D
D
L
E
T
V
-
T
E
S
E
V
I
K
Y
S
A
S
G
F
R
D
F
T
R
L
A
A
S
D
P
T
M
W
R
D
V
C
L
H
N
K
D
A
I
L
E
M
L
A
R
F
S
E
D
L
A
S
L
Q
R
A
I
R
W
G
D
G
D
K
L
F
D
L
F
T
R
T
R
A
I
R
R
S
I
V
Q
A
--------------------------------------------------------------------------------
7
PsiBlast_PDB
58.52
31%
-14
- C2 -
-
3GGP
1
?
A:
[34-313]
--
Q
N
V
L
I
V
G
V
G
F
M
G
G
S
F
A
K
S
L
R
R
S
G
F
K
--
G
K
--
I
Y
G
Y
D
I
N
P
E
S
I
S
K
A
V
D
L
G
I
I
D
E
G
T
T
S
I
A
K
-
V
E
D
F
S
P
D
F
V
M
L
S
S
P
V
R
T
F
R
E
I
A
K
K
L
S
Y
-
I
--
L
S
E
D
A
T
V
T
D
Q
G
S
V
K
G
K
L
V
Y
D
L
E
----
N
I
---
L
G
K
R
F
V
G
G
H
P
I
A
G
T
E
K
S
G
V
E
Y
S
L
D
N
L
Y
E
G
K
K
V
I
L
T
P
T
K
K
-
T
-
D
-
K
K
-
R
L
K
L
V
K
R
V
W
E
D
V
G
G
V
V
E
Y
---
M
S
P
E
L
H
D
Y
V
F
G
V
V
S
H
L
P
H
A
V
A
F
A
L
V
D
T
L
I
H
M
-
S
T
-
P
E
V
D
L
F
K
Y
P
G
G
G
F
K
D
F
T
R
I
A
K
S
D
P
I
M
W
R
D
I
F
L
E
N
K
E
N
V
M
K
A
I
E
G
F
E
K
S
L
N
H
L
K
E
L
I
V
R
E
A
E
E
E
L
V
E
Y
L
K
E
V
K
I
K
R
M
E
I
-----------------------------------------------------------------------------------
48
HHSearch
58.39
31%
6
- C2 -
-
2G5C
1
?
B:
[2-280]
--
Q
N
V
L
I
V
G
V
G
F
M
G
G
S
F
A
K
S
L
R
R
S
--
G
--
F
K
G
K
I
Y
G
Y
D
I
N
P
E
S
I
S
K
A
V
D
L
G
I
I
D
E
G
T
T
S
I
A
K
V
E
D
F
-
S
P
D
F
V
M
L
S
S
P
V
R
T
F
R
E
I
A
K
K
L
S
Y
-
I
-
L
-
S
E
D
A
T
V
T
D
Q
G
S
V
K
G
K
L
V
Y
D
L
E
----
N
I
---
L
G
K
R
F
V
G
G
H
P
I
A
G
T
E
K
S
G
V
E
Y
S
L
D
N
L
Y
E
G
K
K
V
I
L
T
P
T
K
K
-
T
D
K
-
K
R
-
L
K
L
V
K
R
V
W
---
E
D
V
G
G
V
V
E
Y
-
M
S
P
E
L
H
D
Y
V
F
G
V
V
S
H
L
P
H
A
V
A
F
A
L
V
D
T
L
I
H
M
-
S
T
-
P
E
V
D
L
F
K
Y
P
G
G
G
F
K
D
F
T
R
I
A
K
S
D
P
I
M
W
R
D
I
F
L
E
N
K
E
N
V
M
K
A
I
E
G
F
E
K
S
L
N
H
L
K
E
L
I
V
R
E
A
E
E
E
L
V
E
Y
L
K
E
V
K
I
K
R
M
E
------------------------------------------------------------------------------------
25
PsiBlast_CBE
58.18
31%
-15
- C2 -
-
3GGP
1
?
D:
[34-313]
--
Q
N
V
L
I
V
G
V
G
F
M
G
G
S
F
A
K
S
L
R
R
S
G
F
K
--
G
K
--
I
Y
G
Y
D
I
N
P
E
S
I
S
K
A
V
D
L
G
I
I
D
E
G
T
T
S
I
A
K
-
V
E
D
F
S
P
D
F
V
M
L
S
S
P
V
R
T
F
R
E
I
A
K
K
L
S
Y
-
I
--
L
S
E
D
A
T
V
T
D
Q
G
S
V
K
G
K
L
V
Y
D
L
E
----
N
I---
L
G
K
R
F
V
G
G
H
P
I
A
G
T
E
K
S
G
V
E
Y
S
L
D
N
L
Y
E
G
K
K
V
I
L
T
P
T
K
K
-
T
-
D
-
K
K
-
R
L
K
L
V
K
R
V
WED
V
G
G
V
V
E
Y
---
M
S
P
E
L
H
D
Y
V
F
G
V
V
S
H
L
P
H
A
V
A
F
A
L
V
D
T
L
I
H
M
-
S
T
-
P
E
V
D
L
F
K
Y
P
G
G
G
F
K
D
F
T
R
I
A
K
S
D
P
I
M
W
R
D
I
F
L
E
N
K
E
N
V
M
K
A
I
E
G
F
E
K
S
L
N
H
L
K
E
L
I
V
R
E
A
E
E
E
L
V
E
Y
L
K
E
V
K
I
K
R
M
E
I
-----------------------------------------------------------------------------------
33
PsiBlast_CBE
57.89
31%
-19
- C2 -
-
3GGG
2
?
A:
[34-313]
--
Q
N
V
L
I
V
G
V
G
F
M
G
G
S
F
A
K
S
L
R
R
S
G
F
K
--
G
K
--
I
Y
G
Y
D
I
N
P
E
S
I
S
K
A
V
D
L
G
I
I
D
E
G
T
T
S
I
A
K
-
V
E
D
F
S
P
D
F
V
M
L
S
S
P
V
R
T
F
R
E
I
A
K
K
L
S
Y
-
I
--
L
S
E
D
A
T
V
T
D
Q
G
S
V
K
G
K
L
V
Y
D
L
E
----
N
I
---
L
G
K
R
F
V
G
G
H
P
I
A
G
T
E
K
S
G
V
E
Y
S
L
D
N
L
Y
E
G
K
K
V
I
L
T
P
T
K
K
-
T
-
D
-
K
K
-
R
L
K
L
V
K
R
V
W
E
D
V
G
G
V
V
E
Y
---
M
S
P
E
L
H
D
Y
V
F
G
V
V
S
H
L
P
H
A
V
A
F
A
L
V
D
T
L
I
H
M
-
S
T
-
P
E
V
D
L
F
K
Y
P
G
G
G
F
K
D
F
T
R
I
A
K
S
D
P
I
M
W
R
D
I
F
L
E
N
K
E
N
V
M
K
A
I
E
G
F
E
K
S
L
N
H
L
K
E
L
I
V
R
E
A
E
E
E
L
V
E
Y
L
K
E
V
K
I
K
R
M
E
I
-----------------------------------------------------------------------------------
28
PsiBlast_CBE
57.80
31%
-17
- C2 -
-
3GGO
2
?
D:
[34-311]
--
Q
N
V
L
I
V
G
V
G
F
M
G
G
S
F
A
K
S
L
R
R
S
G
F
K
--
G
K
--
I
Y
G
Y
D
I
N
P
E
S
I
S
K
A
V
D
L
G
I
I
D
E
G
T
T
S
I
A
K
-
V
E
D
F
S
P
D
F
V
M
L
S
S
P
V
R
T
F
R
E
I
A
K
K
L
S
Y
-
I
--
L
S
E
D
A
T
V
T
D
Q
G
S
V
K
G
K
L
V
Y
D
L
E
----
N
I
---
L
G
K
R
F
V
G
G
H
P
I
A
G
T
E
K
S
G
V
E
Y
S
L
D
N
L
Y
E
G
K
K
V
I
L
T
P
T
K
K
-
T
-
D
-
K
K
-
R
L
K
L
V
K
R
V
W
E
D
V
G
G
V
V
E
Y
---
M
S
P
E
L
H
D
Y
V
F
G
V
V
S
H
L
P
H
A
V
A
F
A
L
V
D
T
L
I
H
M
-
S
T
-
P
E
V
D
L
F
K
Y
P
G
G
G
F
K
D
F
T
R
I
A
K
S
D
P
I
M
W
R
D
I
F
L
E
N
K
E
N
V
M
K
A
I
E
G
F
E
K
S
L
N
H
L
K
E
L
I
V
R
E
A
E
E
E
L
V
E
Y
L
K
E
V
K
I
K
R
M
-------------------------------------------------------------------------------------
26
PsiBlast_CBE
57.80
31%
-14
- C2 -
-
3GGP
1
?
C:
[34-313]
--
Q
N
V
L
I
V
G
V
G
F
M
G
G
S
F
A
K
S
L
R
R
S
G
F
K
--
G
K
--
I
Y
G
Y
D
I
N
P
E
S
I
S
K
A
V
D
L
G
I
I
D
E
G
T
T
S
I
A
K
-
V
E
D
F
S
P
D
F
V
M
L
S
S
P
V
R
T
F
R
E
I
A
K
K
L
S
Y
-
I
--
L
S
E
D
A
T
V
T
D
Q
G
S
V
K
G
K
L
V
Y
D
L
E
----
N
I---
L
G
K
R
F
V
G
G
H
P
I
A
G
T
E
K
S
G
V
E
Y
S
L
D
N
L
Y
E
G
K
K
V
I
L
T
P
T
K
K
-
T
-
D
-
K
K
-
R
L
K
L
V
K
R
V
WED
V
G
G
V
V
E
Y
---
M
S
P
E
L
H
D
Y
V
F
G
V
V
S
H
L
P
H
A
V
A
F
A
L
V
D
T
L
I
H
M
-
S
T
-
P
E
V
D
L
F
K
Y
P
G
G
G
F
K
D
F
T
R
I
A
K
S
D
P
I
M
W
R
D
I
F
L
E
N
K
E
N
V
M
K
A
I
E
G
F
E
K
S
L
N
H
L
K
E
L
I
V
R
E
A
E
E
E
L
V
E
Y
L
K
E
V
K
I
K
R
M
E
I
-----------------------------------------------------------------------------------
29
PsiBlast_CBE
57.78
31%
-15
- C2 -
-
3GGO
2
?
C:
[34-308]
--
Q
N
V
L
I
V
G
V
G
F
M
G
G
S
F
A
K
S
L
R
R
S
G
F
K
--
G
K
--
I
Y
G
Y
D
I
N
P
E
S
I
S
K
A
V
D
L
G
I
I
D
E
G
T
T
S
I
A
K
-
V
E
D
F
S
P
D
F
V
M
L
S
S
P
V
R
T
F
R
E
I
A
K
K
L
S
Y
-
I
--
L
S
E
D
A
T
V
T
D
Q
G
S
V
K
G
K
L
V
Y
D
L
E
----
N
I
---
L
G
K
R
F
V
G
G
H
P
I
A
G
T
E
K
S
G
V
E
Y
S
L
D
N
L
Y
E
G
K
K
V
I
L
T
P
T
K
K
-
T
-
D
-
K
K
-
R
L
K
L
V
K
R
V
W
E
D
V
G
G
V
V
E
Y
---
M
S
P
E
L
H
D
Y
V
F
G
V
V
S
H
L
P
H
A
V
A
F
A
L
V
D
T
L
I
H
M
-
S
T
-
P
E
V
D
L
F
K
Y
P
G
G
G
F
K
D
F
T
R
I
A
K
S
D
P
I
M
W
R
D
I
F
L
E
N
K
E
N
V
M
K
A
I
E
G
F
E
K
S
L
N
H
L
K
E
L
I
V
R
E
A
E
E
E
L
V
E
Y
L
K
E
V
K
I
----------------------------------------------------------------------------------------
30
PsiBlast_CBE
57.44
31%
-21
- C2 -
-
3GGO
2
?
B:
[34-312]
--
Q
N
V
L
I
V
G
V
G
F
M
G
G
S
F
A
K
S
L
R
R
S
G
F
K
--
G
K
--
I
Y
G
Y
D
I
N
P
E
S
I
S
K
A
V
D
L
G
I
I
D
E
G
T
T
S
I
A
K
-
V
E
D
F
S
P
D
F
V
M
L
S
S
P
V
R
T
F
R
E
I
A
K
K
L
S
Y
-
I
--
L
S
E
D
A
T
V
T
D
Q
G
S
V
K
G
K
L
V
Y
D
L
E
----
N
I
---
L
G
K
R
F
V
G
G
H
P
I
A
G
T
E
K
S
G
V
E
Y
S
L
D
N
L
Y
E
G
K
K
V
I
L
T
P
T
K
K
-
T
-
D
-
K
K
-
R
L
K
L
V
K
R
V
W
E
D
V
G
G
V
V
E
Y
---
M
S
P
E
L
H
D
Y
V
F
G
V
V
S
H
L
P
H
A
V
A
F
A
L
V
D
T
L
I
H
M
-
S
T
-
P
E
V
D
L
F
K
Y
P
G
G
G
F
K
D
F
T
R
I
A
K
S
D
P
I
M
W
R
D
I
F
L
E
N
K
E
N
V
M
K
A
I
E
G
F
E
K
S
L
N
H
L
K
E
L
I
V
R
E
A
E
E
E
L
V
E
Y
L
K
E
V
K
I
K
R
M
E
------------------------------------------------------------------------------------
31
PsiBlast_CBE
57.19
31%
-17
- C2 -
-
3GGG
2
?
C:
[34-308]
--
Q
N
V
L
I
V
G
V
G
F
M
G
G
S
F
A
K
S
L
R
R
S
G
F
K
--
G
K
--
I
Y
G
Y
D
I
N
P
E
S
I
S
K
A
V
D
L
G
I
I
D
E
G
T
T
S
I
A
K
-
V
E
D
F
S
P
D
F
V
M
L
S
S
P
V
R
T
F
R
E
I
A
K
K
L
S
Y
-
I
--
L
S
E
D
A
T
V
T
D
Q
G
S
V
K
G
K
L
V
Y
D
L
E
----
N
I
---
L
G
K
R
F
V
G
G
H
P
I
A
G
T
E
K
S
G
V
E
Y
S
L
D
N
L
Y
E
G
K
K
V
I
L
T
P
T
K
K
-
T
-
D
-
K
K
-
R
L
K
L
V
K
R
V
W
E
D
V
G
G
V
V
E
Y
---
M
S
P
E
L
H
D
Y
V
F
G
V
V
S
H
L
P
H
A
V
A
F
A
L
V
D
T
L
I
H
M
-
S
T
-
P
E
V
D
L
F
K
Y
P
G
G
G
F
K
D
F
T
R
I
A
K
S
D
P
I
M
W
R
D
I
F
L
E
N
K
E
N
V
M
K
A
I
E
G
F
E
K
S
L
N
H
L
K
E
L
I
V
R
E
A
E
E
E
L
V
E
Y
L
K
E
V
K
I
----------------------------------------------------------------------------------------
32
PsiBlast_CBE
55.93
31%
-18
- C2 -
-
3GGG
2
?
B:
[34-310]
--
Q
N
V
L
I
V
G
V
G
F
M
G
G
S
F
A
K
S
L
R
R
S
G
F
K
--
G
K
--
I
Y
G
Y
D
I
N
P
E
S
I
S
K
A
V
D
L
G
I
I
D
E
G
T
T
S
I
A
K
-
V
E
D
F
S
P
D
F
V
M
L
S
S
P
V
R
T
F
R
E
I
A
K
K
L
S
Y
-
I
--
L
S
E
D
A
T
V
T
D
Q
G
S
V
K
G
K
L
V
Y
D
L
E
----
N
I
---
L
G
K
R
F
V
G
G
H
P
I
A
G
T
E
K
S
G
V
E
Y
S
L
D
N
L
Y
E
G
K
K
V
I
L
T
P
T
K
K
-
T
-
D
-
K
K
-
R
L
K
L
V
K
R
V
W
E
D
V
G
G
V
V
E
Y
---
M
S
P
E
L
H
D
Y
V
F
G
V
V
S
H
L
P
H
A
V
A
F
A
L
V
D
T
L
I
H
M
-
S
T
-
P
E
V
D
L
F
K
Y
P
G
G
G
F
K
D
F
T
R
I
A
K
S
D
P
I
M
W
R
D
I
F
L
E
N
K
E
N
V
M
K
A
I
E
G
F
E
K
S
L
N
H
L
K
E
L
I
V
R
E
A
E
E
E
L
V
E
Y
L
K
E
V
K
I
K
R
--------------------------------------------------------------------------------------