@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3XZL0: (2018-01-15 )
MNRKDEHVSLAKAFHDKQKNEFDFVRIIHNPLPQIAVSDVDLSTQAVGFTLSSPFYINAMTGGSEKTKKINQDLAIVAREADLMIATGSVSAALKVPSLADTYTIMRQEYPHGKIIANIGAGTSVERAKEAIRLFHADALQIHLNAPQELVMPEGDRDFTNWKVLIQETQTAIDVPLIVKEVGFGMTRETLNDLAALGVHTVDISGRSGTSFTQIENARRSKRELSYLADWGQSTVSSLLEANEADTSMEILASGGIRNAYDIFKALCLGANAVGTSGTVLTHLMNHGVEETIILMKQWQEELRLLYTMVGATNTAALHQQSLIFSGPVKDWCEARGIDLVKYGRRTEKSVGQK
Atome Classification :
(20 SA)
.........10....---.----...20........30........40........50........60..-.-..-...70........80........90........100.......110.......120---....-----.....130.......140.......150.......160...-.....170.......180.......190.......200.......210.......220-----.------....-..230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350..
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MNR
K
D
E
H
V
S
L
A
K
A
F
H
---D----KQKNE
F
D
F
V
R
I
I
HNPLP
Q
I
A
VSDVDLS
T
Q
A
V
G
F
T
LSS
P
F
Y
I
N
A
MTGG-S-
E
K
-
T
K
K
INQD
L
A
I
V
A
REA
D
L
M
I
ATGS
V
S
A
A
LKVPS
L
A
D
T
Y
T
I
M
R
QEYPH
G
K
I
I
A
NIG-----AGT
S
-----
V
E
R
A
K
E
A
I
R
L
F
HA
D
A
L
Q
I
H
LNA
P
Q
E
LVMPEGDRDFT-N
W
K
V
-
L
I
Q
ETQTAIDV
P
L
I
V
K
E
VGFG
M
T
R
E
T
L
N
D
L
A
A
L
G
V
H
T
V
D
ISGRSGT
S
F
T
Q
I
E
N
A
R
R
S
K
-----
R
------
E
L
S
Y
-
L
A
D
W
G
Q
S
T
V
S
S
L
L
EANEADT
S
M
E
I
L
ASGGI
R
N
A
Y
D
I
F
K
A
L
CLGANAVGT
S
G
T
V
L
T
H
L
M
NHG
V
E
E
T
I
I
L
M
K
Q
W
Q
E
E
L
R
L
L
Y
T
MVGAT
N
T
A
A
L
HQQ
S
L
IFSGP
V
K
D
W
C
E
ARGI
D
L
V
K
YGR
R
T
E
K
SVGQK
34
HHSearch
92.49
42%
-98
- C4 -
-
4N02
1
IDI2_STRPS
A:
[24-353]
T
N
R
K
D
E
H
I
L
Y
A
L
E
Q
K
--------
S
S
Y
N
S
F
D
E
V
E
L
I
H
S
S
L
P
L
Y
N
L
D
E
I
D
L
S
T
E
F
A
G
R
K
W
D
F
P
F
Y
I
N
A
M
T
G
G
-
S
-
N
K
-
G
R
E
I
N
Q
K
L
A
Q
V
A
E
S
C
G
I
L
F
V
T
G
S
Y
S
A
A
L
K
N
P
-
T
D
D
S
F
S
-
V
K
S
S
H
P
N
L
L
L
G
T
N
I
G
-----
L
D
K
P
-----
V
E
L
G
L
Q
T
V
E
E
M
N
P
V
L
L
Q
V
H
V
N
V
M
Q
E
L
L
M
P
E
G
E
R
K
F
R
-
S
W
Q
S
-
H
L
A
D
Y
S
K
Q
I
P
V
P
I
V
L
K
E
V
G
F
G
M
D
A
K
T
I
E
R
A
Y
E
F
G
V
R
T
V
D
L
S
G
R
G
G
T
S
F
A
Y
I
E
N
R
R
S
G
Q
-----
R
--------
D
Y
-
L
N
Q
W
G
Q
S
T
M
Q
A
L
L
N
A
Q
E
W
K
D
K
V
E
L
L
V
S
G
G
V
R
N
P
L
D
M
I
K
C
L
V
F
G
A
K
A
V
G
L
S
R
T
V
L
E
L
V
E
T
Y
T
V
E
E
V
I
G
I
V
Q
G
W
K
A
D
L
R
L
I
M
C
S
L
N
C
A
T
I
A
D
L
Q
K
V
D
Y
L
L
Y
G
K
L
K
E
A
K
D
Q
-------------------
3
PsiBlast_PDB
91.24
42%
-98
- C4 -
-
4N02
1
IDI2_STRPS
A:
[25-349]
-
N
R
K
D
E
H
I
L
Y
A
L
E
-
Q
---
K
----
S
S
Y
N
S
F
D
E
V
E
L
I
H
S
S
L
P
L
Y
N
L
D
E
I
D
L
S
T
E
F
A
G
R
K
W
D
F
P
F
Y
I
N
A
M
T
G
G
-
S
-
N
K
-
G
R
E
I
N
Q
K
L
A
Q
V
A
E
S
C
G
I
L
F
V
T
G
S
Y
S
A
A
L
K
N
P
T
-
D
D
S
F
S
V
-
K
S
S
H
P
N
L
L
L
G
T
N
I
G
-----
L
D
K
P
-----
V
E
L
G
L
Q
T
V
E
E
M
N
P
V
L
L
Q
V
H
V
N
V
M
Q
E
L
L
M
P
E
G
E
R
K
F
R
-
S
W
Q
S
-
H
L
A
D
Y
S
K
Q
I
P
V
P
I
V
L
K
E
V
G
F
G
M
D
A
K
T
I
E
R
A
Y
E
F
G
V
R
T
V
D
L
S
G
R
G
G
T
S
F
A
Y
I
E
N
R
R
S
G
Q
-----
R
------
D
--
Y
-
L
N
Q
W
G
Q
S
T
M
Q
A
L
L
N
A
Q
E
W
K
D
K
V
E
L
L
V
S
G
G
V
R
N
P
L
D
M
I
K
C
L
V
F
G
A
K
A
V
G
L
S
R
T
V
L
E
L
V
E
T
Y
T
V
E
E
V
I
G
I
V
Q
G
W
K
A
D
L
R
L
I
M
C
S
L
N
C
A
T
I
A
D
L
Q
K
V
D
Y
L
L
Y
G
K
L
K
E
-----------------------
52
Fugue
79.78
39%
-24
- C4 -
-
1P0K
-
IDI2_BACSU
B:
[22-349]
-------------------------
E
T
G
L
D
D
I
T
F
V
H
V
S
L
P
D
L
A
L
E
Q
V
D
I
S
T
K
I
G
E
L
S
S
S
S
P
I
F
I
N
A
M
T
G
G
G
G
-
K
L
-
T
Y
E
I
N
K
S
L
A
R
A
A
S
Q
A
G
I
P
L
A
V
G
S
Q
M
S
A
L
K
D
P
S
E
R
L
S
Y
E
I
V
R
K
E
N
P
N
G
L
I
F
A
N
L
G
-----
S
E
A
T
-----
A
A
Q
A
K
E
A
V
E
M
I
G
A
N
A
L
Q
I
H
L
N
V
I
Q
E
I
V
M
R
----
S
F
S
-
G
A
L
K
-
R
I
E
Q
I
C
S
R
V
S
V
P
V
I
V
K
E
V
G
F
G
M
S
K
A
S
A
G
K
L
Y
E
A
G
A
A
A
V
D
I
G
G
R
---------------------------
Q
I
S
F
-
F
N
S
W
G
I
S
T
A
A
S
L
A
E
I
R
S
E
F
P
A
S
T
M
I
A
S
G
G
L
Q
D
A
L
D
V
A
K
A
I
A
L
G
A
S
C
T
G
M
A
G
H
F
L
K
A
L
T
D
S
G
E
E
G
L
L
E
E
I
Q
L
I
L
E
E
L
K
L
I
M
T
V
L
G
A
R
T
I
A
D
L
Q
K
A
P
L
V
I
K
G
E
T
H
H
W
L
T
E
R
G
V
N
T
S
S
Y
S
V
R
--------
31
HHSearch
79.78
40%
-23
- C4 -
-
1P0K
-
IDI2_BACSU
B:
[22-348]
-------------------------
E
T
G
L
D
D
I
T
F
V
H
V
S
L
P
D
L
A
L
E
Q
V
D
I
S
T
K
I
G
E
L
S
S
S
S
P
I
F
I
N
A
M
T
G
G
-
G
G
K
L
-
T
Y
E
I
N
K
S
L
A
R
A
A
S
Q
A
G
I
P
L
A
V
G
S
Q
M
S
A
L
K
D
P
S
E
R
L
S
Y
E
I
V
R
K
E
N
P
N
G
L
I
F
A
N
L
G
-----
S
E
A
T
-----
A
A
Q
A
K
E
A
V
E
M
I
G
A
N
A
L
Q
I
H
L
N
V
I
Q
E
I
V
M
----
R
S
F
S
-
G
A
L
K
-
R
I
E
Q
I
C
S
R
V
S
V
P
V
I
V
K
E
V
G
F
G
M
S
K
A
S
A
G
K
L
Y
E
A
G
A
A
A
V
D
I
G
G
---------------
R
-----
Q
-------
I
S
F
-
F
N
S
W
G
I
S
T
A
A
S
L
A
E
I
R
S
E
F
P
A
S
T
M
I
A
S
G
G
L
Q
D
A
L
D
V
A
K
A
I
A
L
G
A
S
C
T
G
M
A
G
H
F
L
K
A
L
T
D
S
G
E
E
G
L
L
E
E
I
Q
L
I
L
E
E
L
K
L
I
M
T
V
L
G
A
R
T
I
A
D
L
Q
K
A
P
L
V
I
K
G
E
T
H
H
W
L
T
E
R
G
V
N
T
S
S
Y
S
V
---------
22
PsiBlast_CBE
79.41
40%
-25
- C4 -
-
1P0N
2
IDI2_BACSU
B:
[22-349]
-------------------------
E
T
G
L
D
D
I
T
F
V
H
V
S
L
P
D
L
A
L
E
Q
V
D
I
S
T
K
I
G
E
L
S
S
S
S
P
I
F
I
N
A
M
T
G
G
-
G
-
G
K
L
T
Y
E
I
N
K
S
L
A
R
A
A
S
Q
A
G
I
P
L
A
V
G
S
Q
M
S
A
L
K
D
P
S
E
R
L
S
Y
E
I
V
R
K
E
N
P
N
G
L
I
F
A
N
L
G
-----
S
E
A
T
-----
A
A
Q
A
K
E
A
V
E
M
I
G
A
N
A
L
Q
I
H
L
N
V
I
Q
E
I
V
M
------
F
S
-
G
A
L
K
-
R
I
E
Q
I
C
S
R
V
S
V
P
V
I
V
K
E
V
G
F
G
M
S
K
A
S
A
G
K
L
Y
E
A
G
A
A
A
V
D
I
G
G
---------------------
R
------
Q
I
S
F
-
F
N
S
W
G
I
S
T
A
A
S
L
A
E
I
R
S
E
F
P
A
S
T
M
I
A
S
G
G
L
Q
D
A
L
D
V
A
K
A
I
A
L
G
A
S
C
T
G
M
A
G
H
F
L
K
A
L
T
D
S
G
E
E
G
L
L
E
E
I
Q
L
I
L
E
E
L
K
L
I
M
T
V
L
G
A
R
T
I
A
D
L
Q
K
A
P
L
V
I
K
G
E
T
H
H
W
L
T
E
R
G
V
N
T
S
S
Y
S
V
R
--------
1
PsiBlast_PDB
78.68
40%
-22
- C4 -
-
1P0K
-
IDI2_BACSU
A:
[21-349]
------------------------
R
E
T
G
L
D
D
I
T
F
V
H
V
S
L
P
D
L
A
L
E
Q
V
D
I
S
T
K
I
G
E
L
S
S
S
S
P
I
F
I
N
A
M
T
G
G
-
G
-
G
K
L
T
Y
E
I
N
K
S
L
A
R
A
A
S
Q
A
G
I
P
L
A
V
G
S
Q
M
S
A
L
K
D
P
S
E
R
L
S
Y
E
I
V
R
K
E
N
P
N
G
L
I
F
A
N
L
G
-----
S
E
A
T
-----
A
A
Q
A
K
E
A
V
E
M
I
G
A
N
A
L
Q
I
H
L
N
V
I
Q
E
I
--------
F
S
-
G
A
L
K
-
R
I
E
Q
I
C
S
R
V
S
V
P
V
I
V
K
E
V
G
F
G
M
S
K
A
S
A
G
K
L
Y
E
A
G
A
A
A
V
D
I
G
G
---------------------
R
------
Q
I
S
F
-
F
N
S
W
G
I
S
T
A
A
S
L
A
E
I
R
S
E
F
P
A
S
T
M
I
A
S
G
G
L
Q
D
A
L
D
V
A
K
A
I
A
L
G
A
S
C
T
G
M
A
G
H
F
L
K
A
L
T
D
S
G
E
E
G
L
L
E
E
I
Q
L
I
L
E
E
L
K
L
I
M
T
V
L
G
A
R
T
I
A
D
L
Q
K
A
P
L
V
I
K
G
E
T
H
H
W
L
T
E
R
G
V
N
T
S
S
Y
S
V
R
--------
2
PsiBlast_PDB
78.03
40%
-24
- C4 -
-
1P0N
1
IDI2_BACSU
A:
[22-349]
-------------------------
E
T
G
L
D
D
I
T
F
V
H
V
S
L
P
D
L
A
L
E
Q
V
D
I
S
T
K
I
G
E
L
S
S
S
S
P
I
F
I
N
A
M
T
G
G
-
G
-
G
K
L
T
Y
E
I
N
K
S
L
A
R
A
A
S
Q
A
G
I
P
L
A
V
G
S
Q
M
S
A
L
K
D
P
S
E
R
L
S
Y
E
I
V
R
K
E
N
P
N
G
L
I
F
A
N
L
G
-----
S
E
A
T
-----
A
A
Q
A
K
E
A
V
E
M
I
G
A
N
A
L
Q
I
H
L
N
V
I
Q
E
I
--------
F
S
-
G
A
L
K
-
R
I
E
Q
I
C
S
R
V
S
V
P
V
I
V
K
E
V
G
F
G
M
S
K
A
S
A
G
K
L
Y
E
A
G
A
A
A
V
D
I
G
G
---------------------
R
------
Q
I
S
F
-
F
N
S
W
G
I
S
T
A
A
S
L
A
E
I
R
S
E
F
P
A
S
T
M
I
A
S
G
G
L
Q
D
A
L
D
V
A
K
A
I
A
L
G
A
S
C
T
G
M
A
G
H
F
L
K
A
L
T
D
S
G
E
E
G
L
L
E
E
I
Q
L
I
L
E
E
L
K
L
I
M
T
V
L
G
A
R
T
I
A
D
L
Q
K
A
P
L
V
I
K
G
E
T
H
H
W
L
T
E
R
G
V
N
T
S
S
Y
S
V
R
--------
32
HHSearch
74.42
31%
1
- C4 -
-
3B05
2
IDI2_SULSH
D:
[5-364]
V
N
R
K
V
E
H
V
E
I
A
A
F
E
N
VDG
L
----
S
S
S
T
F
L
N
D
V
I
L
V
H
Q
G
F
P
G
I
S
F
S
E
I
N
T
K
T
K
F
F
R
K
E
I
S
V
P
V
M
V
T
G
M
T
G
G
-
R
-
N
E
-
L
G
R
I
N
K
I
I
A
E
V
A
E
K
F
G
I
P
M
G
V
G
S
Q
R
V
A
I
E
K
A
E
A
R
E
S
F
A
I
V
R
K
V
A
P
T
I
P
I
I
A
N
L
G
-----
M
P
Q
L
VKGYG
L
K
E
F
Q
D
A
I
Q
M
I
E
A
D
A
I
A
V
H
L
N
P
A
Q
E
V
F
Q
P
E
G
E
P
E
Y
Q
I
Y
A
L
E
-
K
L
R
D
I
S
K
E
L
S
V
P
I
I
V
K
E
S
G
N
G
I
S
M
E
T
A
K
L
L
Y
S
Y
G
I
K
N
F
D
T
S
G
Q
G
G
T
N
W
I
A
I
E
M
I
R
D
I
R
RGNWK
A
------
E
S
A
K
N
F
L
D
W
G
V
P
T
A
A
S
I
M
E
V
R
Y
S
V
P
D
S
F
L
V
G
S
G
G
I
R
S
G
L
D
A
A
K
A
I
A
L
G
A
D
I
A
G
M
A
L
P
V
L
K
S
A
I
-
E
G
K
E
S
L
E
Q
F
F
R
K
I
I
F
E
L
K
A
A
M
M
L
T
G
S
K
D
V
D
A
L
K
K
T
S
I
V
I
L
G
K
L
K
E
W
A
E
Y
R
G
I
N
L
S
I
Y
E
K
V
--------
33
HHSearch
74.41
31%
-1
- C4 -
-
3VKJ
1
IDI2_SULSH
A:
[5-364]
V
N
R
K
V
E
H
V
E
I
A
A
F
E
N
VDG
L
----
S
S
S
T
F
L
N
D
V
I
L
V
H
Q
G
F
P
G
I
S
F
S
E
I
N
T
K
T
K
F
F
R
K
E
I
S
V
P
V
M
V
T
G
M
T
G
G
-
R
-
N
E
-
L
G
R
I
N
K
I
I
A
E
V
A
E
K
F
G
I
P
M
G
V
G
S
Q
R
V
A
I
E
K
A
E
A
R
E
S
F
A
I
V
R
K
V
A
P
T
I
P
I
I
A
N
L
G
-----
M
P
Q
L
V
K
GYG
L
K
E
F
Q
D
A
I
Q
M
I
E
A
D
A
I
A
V
H
L
N
P
A
Q
E
V
F
Q
P
E
G
E
P
E
Y
Q
I
Y
A
L
E
-
K
L
R
D
I
S
K
E
L
S
V
P
I
I
V
K
E
S
G
N
G
I
S
M
E
T
A
K
L
L
Y
S
Y
G
I
K
N
F
D
T
S
G
Q
G
G
T
N
W
I
A
I
E
M
I
R
D
I
R
R
GNWK
A
------
E
S
A
K
N
F
L
D
W
G
V
P
T
A
A
S
I
M
E
V
R
Y
S
V
P
D
S
F
L
V
G
S
G
G
I
R
S
G
L
D
A
A
K
A
I
A
L
G
A
D
I
A
G
M
A
L
P
V
L
K
S
A
I
-
E
G
K
E
S
L
E
Q
F
F
R
K
I
I
F
E
L
K
A
A
M
M
L
T
G
S
K
D
V
D
A
L
K
K
T
S
I
V
I
L
G
K
L
K
E
W
A
E
Y
R
G
I
N
L
S
I
Y
E
K
V
--------
5
PsiBlast_PDB
72.68
30%
25
- C4 -
-
2ZRV
1
IDI2_SULSH
A:
[7-361]
--
R
K
V
E
H
V
E
I
A
-
A
F
E
---
N
VDGL
S
S
S
T
F
L
N
D
V
I
L
V
H
Q
G
F
P
G
I
S
F
S
E
I
N
T
K
T
K
F
F
R
K
E
I
S
V
P
V
M
V
T
G
M
T
G
G
-
R
-
N
E
-
L
G
R
I
N
K
I
I
A
E
V
A
E
K
F
G
I
P
M
G
V
G
S
Q
R
V
A
I
E
K
A
E
A
R
E
S
F
A
I
V
R
K
V
A
P
T
I
P
I
I
A
N
L
G
M
P
Q
L
V
K
G
Y
G
-----
L
K
E
F
Q
D
A
I
Q
M
I
E
A
D
A
I
A
V
H
L
N
P
A
Q
E
V
F
Q
P
E
G
E
P
E
Y
Q
-
I
Y
A
L
E
K
L
R
D
I
S
K
E
L
S
V
P
I
I
V
K
E
S
G
N
G
I
S
M
E
T
A
K
L
L
Y
S
Y
G
I
K
N
F
D
T
S
G
Q
G
G
T
N
W
I
A
I
E
M
I
R
D
I
R
-----
R
GNWK
A
E
S
A
K
N
-
F
L
D
W
G
V
P
T
A
A
S
I
M
E
V
R
Y
S
V
P
D
S
F
L
V
G
S
G
G
I
R
S
G
L
D
A
A
K
A
I
A
L
G
A
D
I
A
G
M
A
L
P
V
L
K
S
A
I
-
E
G
K
E
S
L
E
Q
F
F
R
K
I
I
F
E
L
K
A
A
M
M
L
T
G
S
K
D
V
D
A
L
K
K
T
S
I
V
I
L
G
K
L
K
E
W
A
E
Y
R
G
I
N
L
S
I
Y
-----------
11
PsiBlast_PDB
72.50
30%
28
- C4 -
-
3B04
1
IDI2_SULSH
A:
[6-361]
-
N
R
K
V
E
H
V
E
I
A
-
A
F
E
---
N
VDGL
S
S
S
T
F
L
N
D
V
I
L
V
H
Q
G
F
P
G
I
S
F
S
E
I
N
T
K
T
K
F
F
R
K
E
I
S
V
P
V
M
V
T
G
M
T
G
G
-
R
-
N
E
-
L
G
R
I
N
K
I
I
A
E
V
A
E
K
F
G
I
P
M
G
V
G
S
Q
R
V
A
I
E
K
A
E
A
R
E
S
F
A
I
V
R
K
V
A
P
T
I
P
I
I
A
N
L
G
M
P
Q
L
V
K
G
Y
G
-----
L
K
E
F
Q
D
A
I
Q
M
I
E
A
D
A
I
A
V
H
L
N
P
A
Q
E
V
F
Q
P
E
G
E
P
E
Y
Q
-
I
Y
A
L
E
K
L
R
D
I
S
K
E
L
S
V
P
I
I
V
K
E
S
G
N
G
I
S
M
E
T
A
K
L
L
Y
S
Y
G
I
K
N
F
D
T
S
G
Q
G
G
T
N
W
I
A
I
E
M
I
R
D
I
R
-----
R
GNWK
A
E
S
A
K
N
-
F
L
D
W
G
V
P
T
A
A
S
I
M
E
V
R
Y
S
V
P
D
S
F
L
V
G
S
G
G
I
R
S
G
L
D
A
A
K
A
I
A
L
G
A
D
I
A
G
M
A
L
P
V
L
K
S
A
I
-
E
G
K
E
S
L
E
Q
F
F
R
K
I
I
F
E
L
K
A
A
M
M
L
T
G
S
K
D
V
D
A
L
K
K
T
S
I
V
I
L
G
K
L
K
E
W
A
E
Y
R
G
I
N
L
S
I
Y
-----------
7
PsiBlast_PDB
72.44
30%
26
- C4 -
-
2ZRX
2
IDI2_SULSH
A:
[5-361]
V
N
R
K
V
E
H
V
E
I
A
-
A
F
E
---
N
VDGL
S
S
S
T
F
L
N
D
V
I
L
V
H
Q
G
F
P
G
I
S
F
S
E
I
N
T
K
T
K
F
F
R
K
E
I
S
V
P
V
M
V
T
G
M
T
G
G
-
R
-
N
E
-
L
G
R
I
N
K
I
I
A
E
V
A
E
K
F
G
I
P
M
G
V
G
S
Q
R
V
A
I
E
K
A
E
A
R
E
S
F
A
I
V
R
K
V
A
P
T
I
P
I
I
A
N
L
G
M
P
Q
L
V
K
G
Y
G
-----
L
K
E
F
Q
D
A
I
Q
M
I
E
A
D
A
I
A
V
H
L
N
P
A
Q
E
V
F
Q
P
E
G
E
P
E
Y
Q
-
I
Y
A
L
E
K
L
R
D
I
S
K
E
L
S
V
P
I
I
V
K
E
S
G
N
G
I
S
M
E
T
A
K
L
L
Y
S
Y
G
I
K
N
F
D
T
S
G
Q
G
G
T
N
W
I
A
I
E
M
I
R
D
I
R
-----
R
GNWK
A
E
S
A
K
N
-
F
L
D
W
G
V
P
T
A
A
S
I
M
E
V
R
Y
S
V
P
D
S
F
L
V
G
S
G
G
I
R
S
G
L
D
A
A
K
A
I
A
L
G
A
D
I
A
G
M
A
L
P
V
L
K
S
A
I
-
E
G
K
E
S
L
E
Q
F
F
R
K
I
I
F
E
L
K
A
A
M
M
L
T
G
S
K
D
V
D
A
L
K
K
T
S
I
V
I
L
G
K
L
K
E
W
A
E
Y
R
G
I
N
L
S
I
Y
-----------
10
PsiBlast_PDB
72.11
30%
25
- C4 -
-
3B03
1
IDI2_SULSH
A:
[5-361]
V
N
R
K
V
E
H
V
E
I
A
-
A
F
E
---
N
VDGL
S
S
S
T
F
L
N
D
V
I
L
V
H
Q
G
F
P
G
I
S
F
S
E
I
N
T
K
T
K
F
F
R
K
E
I
S
V
P
V
M
V
T
G
M
T
G
G
-
R
-
N
E
-
L
G
R
I
N
K
I
I
A
E
V
A
E
K
F
G
I
P
M
G
V
G
S
Q
R
V
A
I
E
K
A
E
A
R
E
S
F
A
I
V
R
K
V
A
P
T
I
P
I
I
A
N
L
G
M
P
Q
L
V
K
G
Y
G
-----
L
K
E
F
Q
D
A
I
Q
M
I
E
A
D
A
I
A
V
H
L
N
P
A
Q
E
V
F
Q
P
E
G
E
P
E
Y
Q
-
I
Y
A
L
E
K
L
R
D
I
S
K
E
L
S
V
P
I
I
V
K
E
S
G
N
G
I
S
M
E
T
A
K
L
L
Y
S
Y
G
I
K
N
F
D
T
S
G
Q
G
G
T
N
W
I
A
I
E
M
I
R
D
I
R
-----
R
GNWK
A
E
S
A
K
N
-
F
L
D
W
G
V
P
T
A
A
S
I
M
E
V
R
Y
S
V
P
D
S
F
L
V
G
S
G
G
I
R
S
G
L
D
A
A
K
A
I
A
L
G
A
D
I
A
G
M
A
L
P
V
L
K
S
A
I
-
E
G
K
E
S
L
E
Q
F
F
R
K
I
I
F
E
L
K
A
A
M
M
L
T
G
S
K
D
V
D
A
L
K
K
T
S
I
V
I
L
G
K
L
K
E
W
A
E
Y
R
G
I
N
L
S
I
Y
-----------
12
PsiBlast_PDB
72.03
30%
26
- C4 -
-
3B05
2
IDI2_SULSH
A:
[5-361]
V
N
R
K
V
E
H
V
E
I
A
-
A
F
E
---
N
VDGL
S
S
S
T
F
L
N
D
V
I
L
V
H
Q
G
F
P
G
I
S
F
S
E
I
N
T
K
T
K
F
F
R
K
E
I
S
V
P
V
M
V
T
G
M
T
G
G
-
R
-
N
E
-
L
G
R
I
N
K
I
I
A
E
V
A
E
K
F
G
I
P
M
G
V
G
S
Q
R
V
A
I
E
K
A
E
A
R
E
S
F
A
I
V
R
K
V
A
P
T
I
P
I
I
A
N
L
G
M
P
Q
L
V
K
G
Y
G
-----
L
K
E
F
Q
D
A
I
Q
M
I
E
A
D
A
I
A
V
H
L
N
P
A
Q
E
V
F
Q
P
E
G
E
P
E
Y
Q
-
I
Y
A
L
E
K
L
R
D
I
S
K
E
L
S
V
P
I
I
V
K
E
S
G
N
G
I
S
M
E
T
A
K
L
L
Y
S
Y
G
I
K
N
F
D
T
S
G
Q
G
G
T
N
W
I
A
I
E
M
I
R
D
I
R
-----
R
GNWK
A
E
S
A
K
N
-
F
L
D
W
G
V
P
T
A
A
S
I
M
E
V
R
Y
S
V
P
D
S
F
L
V
G
S
G
G
I
R
S
G
L
D
A
A
K
A
I
A
L
G
A
D
I
A
G
M
A
L
P
V
L
K
S
A
I
-
E
G
K
E
S
L
E
Q
F
F
R
K
I
I
F
E
L
K
A
A
M
M
L
T
G
S
K
D
V
D
A
L
K
K
T
S
I
V
I
L
G
K
L
K
E
W
A
E
Y
R
G
I
N
L
S
I
Y
-----------
6
PsiBlast_PDB
71.97
30%
28
- C4 -
-
2ZRW
2
IDI2_SULSH
A:
[5-361]
V
N
R
K
V
E
H
V
E
I
A
-
A
F
E
---
N
VDGL
S
S
S
T
F
L
N
D
V
I
L
V
H
Q
G
F
P
G
I
S
F
S
E
I
N
T
K
T
K
F
F
R
K
E
I
S
V
P
V
M
V
T
G
M
T
G
G
-
R
-
N
E
-
L
G
R
I
N
K
I
I
A
E
V
A
E
K
F
G
I
P
M
G
V
G
S
Q
R
V
A
I
E
K
A
E
A
R
E
S
F
A
I
V
R
K
V
A
P
T
I
P
I
I
A
N
L
G
M
P
Q
L
V
K
G
Y
G
-----
L
K
E
F
Q
D
A
I
Q
M
I
E
A
D
A
I
A
V
H
L
N
P
A
Q
E
V
F
Q
P
E
G
E
P
E
Y
Q
-
I
Y
A
L
E
K
L
R
D
I
S
K
E
L
S
V
P
I
I
V
K
E
S
G
N
G
I
S
M
E
T
A
K
L
L
Y
S
Y
G
I
K
N
F
D
T
S
G
Q
G
G
T
N
W
I
A
I
E
M
I
R
D
I
R
-----
R
GNWK
A
E
S
A
K
N
-
F
L
D
W
G
V
P
T
A
A
S
I
M
E
V
R
Y
S
V
P
D
S
F
L
V
G
S
G
G
I
R
S
G
L
D
A
A
K
A
I
A
L
G
A
D
I
A
G
M
A
L
P
V
L
K
S
A
I
-
E
G
K
E
S
L
E
Q
F
F
R
K
I
I
F
E
L
K
A
A
M
M
L
T
G
S
K
D
V
D
A
L
K
K
T
S
I
V
I
L
G
K
L
K
E
W
A
E
Y
R
G
I
N
L
S
I
Y
-----------
13
PsiBlast_PDB
71.95
30%
27
- C4 -
-
3B06
2
IDI2_SULSH
A:
[5-361]
V
N
R
K
V
E
H
V
E
I
A
-
A
F
E
---
N
VDGL
S
S
S
T
F
L
N
D
V
I
L
V
H
Q
G
F
P
G
I
S
F
S
E
I
N
T
K
T
K
F
F
R
K
E
I
S
V
P
V
M
V
T
G
M
T
G
G
-
R
-
N
E
-
L
G
R
I
N
K
I
I
A
E
V
A
E
K
F
G
I
P
M
G
V
G
S
Q
R
V
A
I
E
K
A
E
A
R
E
S
F
A
I
V
R
K
V
A
P
T
I
P
I
I
A
N
L
G
M
P
Q
L
V
K
G
Y
G
-----
L
K
E
F
Q
D
A
I
Q
M
I
E
A
D
A
I
A
V
H
L
N
P
A
Q
E
V
F
Q
P
E
G
E
P
E
Y
Q
-
I
Y
A
L
E
K
L
R
D
I
S
K
E
L
S
V
P
I
I
V
K
E
S
G
N
G
I
S
M
E
T
A
K
L
L
Y
S
Y
G
I
K
N
F
D
T
S
G
Q
G
G
T
N
W
I
A
I
E
M
I
R
D
I
R
-----
R
GNWK
A
E
S
A
K
N
-
F
L
D
W
G
V
P
T
A
A
S
I
M
E
V
R
Y
S
V
P
D
S
F
L
V
G
S
G
G
I
R
S
G
L
D
A
A
K
A
I
A
L
G
A
D
I
A
G
M
A
L
P
V
L
K
S
A
I
-
E
G
K
E
S
L
E
Q
F
F
R
K
I
I
F
E
L
K
A
A
M
M
L
T
G
S
K
D
V
D
A
L
K
K
T
S
I
V
I
L
G
K
L
K
E
W
A
E
Y
R
G
I
N
L
S
I
Y
-----------
14
PsiBlast_PDB
71.94
30%
24
- C4 -
-
3VKJ
1
IDI2_SULSH
A:
[5-361]
V
N
R
K
V
E
H
V
E
I
A
-
A
F
E
---
N
VDGL
S
S
S
T
F
L
N
D
V
I
L
V
H
Q
G
F
P
G
I
S
F
S
E
I
N
T
K
T
K
F
F
R
K
E
I
S
V
P
V
M
V
T
G
M
T
G
G
-
R
-
N
E
-
L
G
R
I
N
K
I
I
A
E
V
A
E
K
F
G
I
P
M
G
V
G
S
Q
R
V
A
I
E
K
A
E
A
R
E
S
F
A
I
V
R
K
V
A
P
T
I
P
I
I
A
N
L
G
M
P
Q
L
V
K
G
Y
G
-----
L
K
E
F
Q
D
A
I
Q
M
I
E
A
D
A
I
A
V
H
L
N
P
A
Q
E
V
F
Q
P
E
G
E
P
E
Y
Q
-
I
Y
A
L
E
K
L
R
D
I
S
K
E
L
S
V
P
I
I
V
K
E
S
G
N
G
I
S
M
E
T
A
K
L
L
Y
S
Y
G
I
K
N
F
D
T
S
G
Q
G
G
T
N
W
I
A
I
E
M
I
R
D
I
R
-----
R
GNWK
A
E
S
A
K
N
-
F
L
D
W
G
V
P
T
A
A
S
I
M
E
V
R
Y
S
V
P
D
S
F
L
V
G
S
G
G
I
R
S
G
L
D
A
A
K
A
I
A
L
G
A
D
I
A
G
M
A
L
P
V
L
K
S
A
I
-
E
G
K
E
S
L
E
Q
F
F
R
K
I
I
F
E
L
K
A
A
M
M
L
T
G
S
K
D
V
D
A
L
K
K
T
S
I
V
I
L
G
K
L
K
E
W
A
E
Y
R
G
I
N
L
S
I
Y
-----------
4
PsiBlast_PDB
71.51
30%
21
- C4 -
-
2ZRU
1
IDI2_SULSH
A:
[9-361]
----
V
E
H
V
E
I
A
-
A
F
E
---
N
VDGL
S
S
S
T
F
L
N
D
V
I
L
V
H
Q
G
F
P
G
I
S
F
S
E
I
N
T
K
T
K
F
F
R
K
E
I
S
V
P
V
M
V
T
G
M
T
-----
N
E
-
L
G
R
I
N
K
I
I
A
E
V
A
E
K
F
G
I
P
M
G
V
G
S
Q
R
V
A
I
E
K
A
E
A
R
E
S
F
A
I
V
R
K
V
A
P
T
I
P
I
I
A
N
L
G
M
P
Q
L
V
K
G
Y
G
-----
L
K
E
F
Q
D
A
I
Q
M
I
E
A
D
A
I
A
V
H
L
N
P
A
Q
E
V
F
Q
P
E
G
E
P
E
Y
Q
-
I
Y
A
L
E
K
L
R
D
I
S
K
E
L
S
V
P
I
I
V
K
E
S
G
N
G
I
S
M
E
T
A
K
L
L
Y
S
Y
G
I
K
N
F
D
T
S
G
Q
G
G
T
N
W
I
A
I
E
M
I
R
D
I
R
-----
R
GNWK
A
E
S
A
K
N
-
F
L
D
W
G
V
P
T
A
A
S
I
M
E
V
R
Y
S
V
P
D
S
F
L
V
G
S
G
G
I
R
S
G
L
D
A
A
K
A
I
A
L
G
A
D
I
A
G
M
A
L
P
V
L
K
S
A
I
-
E
G
K
E
S
L
E
Q
F
F
R
K
I
I
F
E
L
K
A
A
M
M
L
T
G
S
K
D
V
D
A
L
K
K
T
S
I
V
I
L
G
K
L
K
E
W
A
E
Y
R
G
I
N
L
S
I
Y
-----------
9
PsiBlast_PDB
71.37
30%
27
- C4 -
-
2ZRZ
2
IDI2_SULSH
A:
[5-361]
V
N
R
K
V
E
H
V
E
I
A
-
A
F
E
---
N
VDGL
S
S
S
T
F
L
N
D
V
I
L
V
H
Q
G
F
P
G
I
S
F
S
E
I
N
T
K
T
K
F
F
R
K
E
I
S
V
P
V
M
V
T
G
M
T
G
G
-
R
-
N
E
-
L
G
R
I
N
K
I
I
A
E
V
A
E
K
F
G
I
P
M
G
V
G
S
Q
R
V
A
I
E
K
A
E
A
R
E
S
F
A
I
V
R
K
V
A
P
T
I
P
I
I
A
N
L
G
M
P
Q
L
V
K
G
Y
G
-----
L
K
E
F
Q
D
A
I
Q
M
I
E
A
D
A
I
A
V
H
L
N
P
A
Q
E
V
F
Q
P
E
G
E
P
E
Y
Q
-
I
Y
A
L
E
K
L
R
D
I
S
K
E
L
S
V
P
I
I
V
K
E
S
G
N
G
I
S
M
E
T
A
K
L
L
Y
S
Y
G
I
K
N
F
D
T
S
G
Q
G
G
T
N
W
I
A
I
E
M
I
R
D
I
R
-----
R
GNWK
A
E
S
A
K
N
-
F
L
D
W
G
V
P
T
A
A
S
I
M
E
V
R
Y
S
V
P
D
S
F
L
V
G
S
G
G
I
R
S
G
L
D
A
A
K
A
I
A
L
G
A
D
I
A
G
M
A
L
P
V
L
K
S
A
I
-
E
G
K
E
S
L
E
Q
F
F
R
K
I
I
F
E
L
K
A
A
M
M
L
T
G
S
K
D
V
D
A
L
K
K
T
S
I
V
I
L
G
K
L
K
E
W
A
E
Y
R
G
I
N
L
S
I
Y
-----------
8
PsiBlast_PDB
71.31
30%
27
- C4 -
-
2ZRY
2
IDI2_SULSH
A:
[5-361]
V
N
R
K
V
E
H
V
E
I
A
-
A
F
E
---
N
VDGL
S
S
S
T
F
L
N
D
V
I
L
V
H
Q
G
F
P
G
I
S
F
S
E
I
N
T
K
T
K
F
F
R
K
E
I
S
V
P
V
M
V
T
G
M
T
G
G
-
R
-
N
E
-
L
G
R
I
N
K
I
I
A
E
V
A
E
K
F
G
I
P
M
G
V
G
S
Q
R
V
A
I
E
K
A
E
A
R
E
S
F
A
I
V
R
K
V
A
P
T
I
P
I
I
A
N
L
G
M
P
Q
L
V
K
G
Y
G
-----
L
K
E
F
Q
D
A
I
Q
M
I
E
A
D
A
I
A
V
H
L
N
P
A
Q
E
V
F
Q
P
E
G
E
P
E
Y
Q
-
I
Y
A
L
E
K
L
R
D
I
S
K
E
L
S
V
P
I
I
V
K
E
S
G
N
G
I
S
M
E
T
A
K
L
L
Y
S
Y
G
I
K
N
F
D
T
S
G
Q
G
G
T
N
W
I
A
I
E
M
I
R
D
I
R
-----
R
GNWK
A
E
S
A
K
N
-
F
L
D
W
G
V
P
T
A
A
S
I
M
E
V
R
Y
S
V
P
D
S
F
L
V
G
S
G
G
I
R
S
G
L
D
A
A
K
A
I
A
L
G
A
D
I
A
G
M
A
L
P
V
L
K
S
A
I
-
E
G
K
E
S
L
E
Q
F
F
R
K
I
I
F
E
L
K
A
A
M
M
L
T
G
S
K
D
V
D
A
L
K
K
T
S
I
V
I
L
G
K
L
K
E
W
A
E
Y
R
G
I
N
L
S
I
Y
-----------