@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3Y284: (2018-01-29 )
MMNLSNRFSPRLSRIEVSKIRQFDQQISSIPDVIKLTLGEPDFPTPEHVKQAGIAAIEEDFSHYTGMRGLEELREAACIFQQQRYGLTYDPQTEVLTTVGATEAIASALLSVLEEGDKVLIPAPAYSGYQPLVELAGAELIPIDTSDTGFVCQPEQFERAFEQYGSAVKAVILNYPNNPTGTTLSAKQLKAIAEVLKKYPVFVISDEVYAELTYSGTHMSIATYLPEQTIVISGLSKSHAMTGWRVGFIFAQKALIDELIKVHQYLVTAATTMSQKAAAEALINGVKDSENMKEQYQTRRDYLVQQLAPLGFEVTQPNGAFYLFCKLPAAIQTDSWQFCVELAEQAKVACIPGIAFGPEGEGYIRISYASSMEKLHEACKRIKDFLTEQ
Atome Classification :
(26 SA)
.........10........20........30---.........40........50.......-.---60........70........80........90........100.......110.......120.......130....-...--140...-..----------.---------.150.......160......----.170.......180.......190.......200.......210..-.-.-.-..220..--..--.---..230.......240.......250.......260.......270.......280-..------.-------.-...---290----........300.......310........320.......-330-----.-.----------......340.......350....-...-----360------.......370.......380.......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MMNLSNRFSP
R
L
S
R
I
E
V
S
K
I
R
Q
F
D
Q
Q
I
S
SI----P
D
V
I
K
L
TLGEPDFP
T
P
E
H
V
K
Q
A
G
I
A
A
I
E
-
E
---
D
F
S
H
Y
TG
M
R
G
L
E
E
L
R
E
A
A
C
I
F
Q
Q
QRYGLTYDPQT
E
V
L
T
TVG
A
T
E
A
I
A
S
A
L
L
S
V
L
EEG
D
K
V
L
I
PAPAYSG
Y
Q
P
L
V
E
LA-G
A
E
--
L
I
P
IDT-SD----------T---------G
F
V
CQ
P
E
Q
F
E
R
A
F
E
Q
Y
G
S
A
V
----
K
A
V
I
L
NYPNNPTGTTL
S
A
K
Q
L
K
A
I
A
E
V
L
K
KY
P
V
F
V
ISD
E
V
Y
A
E
L
TY-S-G-T-
H
M
S
I
A
TY--LP--E---
Q
T
I
V
I
SGLSKSHAMTG
W
R
V
G
F
I
F
A
Q
K
A
L
I
D
E
L
I
K
V
H
Q
Y
L
V
T
A
A
T
T
M
S
Q
K
A
A
A
E
A
L
-
I
N------G-------V-KD
S
---
E
N
-----
M
K
E
Q
Y
Q
T
R
R
D
Y
L
V
Q
Q
LAPL-
G
F
E
V
TQPN
G
A
F
Y
L
F
CKLPA-AI------Q-T----------D
S
W
Q
F
C
V
E
L
A
E
QA
K
V
A
CIPGIAF-GPE-----G
E
G
------
Y
I
R
I
S
Y
A
S
S
M
E
K
L
H
E
A
C
K
R
I
K
D
F
LTEQ
79
HHSearch
99.52
60%
-60
- C1 -
-
4MY5
-
?
A:
[1-388]
-
M
D
L
S
K
R
F
N
K
N
L
N
K
I
E
V
S
M
I
R
Q
F
D
Q
S
I
S
D
I
----
P
D
V
L
K
L
T
L
G
E
P
D
F
A
T
P
K
H
I
K
E
A
A
K
R
A
I
D
-
A
---
D
E
S
H
Y
T
G
M
A
G
L
L
A
L
R
Q
A
A
S
A
F
V
K
E
K
Y
H
L
T
Y
N
P
D
N
E
I
L
V
T
I
G
A
T
E
A
L
S
A
S
L
T
A
I
L
E
P
G
D
K
V
L
L
P
A
P
A
Y
P
G
Y
E
P
V
V
N
L
V
-
G
A
E
--
V
V
E
I
D
T
-
R
S
----------
N
---------
D
F
V
L
T
P
E
M
L
E
E
A
I
L
K
E
G
E
A
L
----
K
A
V
I
L
N
Y
P
T
N
P
T
G
V
T
Y
S
R
Q
Q
I
K
N
L
A
E
V
L
K
K
Y
P
I
F
V
I
S
D
E
V
Y
A
E
L
T
Y
-
T
-
G
E
S
-
H
V
S
I
A
E
Y
--
L
P
--
D
---
Q
T
I
L
I
S
G
L
S
K
S
H
A
M
T
G
W
R
L
G
L
I
F
A
P
A
V
L
T
A
Q
L
I
K
S
H
Q
Y
L
V
T
A
A
T
T
S
V
Q
F
A
A
I
E
A
L
-
T
N
------
G
-------
K
-
D
D
A
---
L
P
-----
M
K
E
E
Y
I
K
R
R
D
Y
I
I
E
K
M
E
A
M
-
K
F
K
I
I
K
P
D
G
A
F
Y
I
F
A
K
I
P
V
-
A
Q
------
G
-
Q
----------
D
S
F
K
F
L
Q
D
F
A
K
E
K
A
V
A
F
I
P
G
V
A
F
-
G
K
Y
-----
G
E
G
------
Y
L
R
I
S
Y
A
A
S
M
E
T
I
K
E
A
M
K
R
L
K
E
F
M
E
Q
-
83
HHSearch
76.24
38%
-40
* C1 *
-
1GDE
4
?
A:
[2-385]
------
A
L
S
D
R
L
E
L
V
S
A
S
E
I
R
K
L
F
D
I
A
A
G
M
----
K
D
V
I
S
L
G
I
G
E
P
D
F
D
T
P
Q
H
I
K
E
Y
A
K
E
A
L
D
-
K
---
G
L
T
H
Y
G
P
N
I
G
L
L
E
L
R
E
A
I
A
E
K
L
K
K
Q
N
G
I
E
A
D
P
K
T
E
I
M
V
L
L
G
A
N
Q
A
F
L
M
G
L
S
A
F
L
K
D
G
E
E
V
L
I
P
T
P
A
F
V
S
Y
A
P
A
V
I
L
A
-
G
G
K
--
P
V
E
V
P
T
-
Y
E
E---------
D
---------
E
F
R
L
N
V
D
E
L
K
K
Y
V
---
T
D
K
T
----
R
A
L
I
I
N
S
P
C
N
P
T
G
A
V
L
T
K
K
D
L
E
E
I
A
D
F
V
V
E
H
D
L
I
V
I
S
D
E
V
Y
E
H
F
I
Y
-
D
-
D
-
A
R
H
Y
S
I
A
S
L
DG
M
F
--
E
---
R
T
I
T
V
N
G
F
S
K
T
F
A
M
T
G
W
R
L
G
F
V
A
A
P
S
W
I
I
E
R
M
V
K
F
Q
M
Y
N
A
T
C
P
V
T
F
I
Q
Y
A
A
A
K
A
L
-
K
D
------
E
R
S
-----
W
-
K
A
V
---
E
E
-----
M
R
K
E
Y
D
R
R
R
K
L
V
W
K
R
L
N
E
M
-
G
L
P
T
V
K
P
K
G
A
F
Y
I
F
P
R
I
R
D
T
G
L
------
T
-
S
------------
K
K
F
S
E
L
M
L
K
E
A
R
V
A
V
V
P
G
S
A
F
-
G
K
A
-----
G
E
G
------
Y
V
R
I
S
Y
A
T
A
Y
E
K
L
E
E
A
M
D
R
M
E
R
V
L
K
E
-
23
PsiBlast_CBE
74.78
37%
-23
- C1 -
-
1GD9
2
?
B:
[3-386]
-------
L
S
D
R
L
E
L
V
S
A
S
E
I
R
K
L
F
D
I
A
A
G
M
----
K
D
V
I
S
L
G
I
G
E
P
D
F
D
T
P
Q
H
I
K
E
Y
A
K
E
A
L
D
-
K
---
G
L
T
H
Y
G
P
N
I
G
L
L
E
L
R
E
A
I
A
E
K
L
K
K
Q
N
G
I
E
A
D
P
K
T
E
I
M
V
L
L
G
A
N
Q
A
F
L
M
G
L
S
A
F
L
K
D
G
E
E
V
L
I
P
T
P
A
F
V
S
Y
A
P
A
V
I
L
A
-
G
G
K
--
P
V
E
V
P
T
Y
E
E
----------
D
---------
E
F
R
L
N
V
D
E
L
K
K
---
Y
V
T
D
K
T
----
R
A
L
I
I
N
S
P
C
N
P
T
G
A
V
L
T
K
K
D
L
E
E
I
A
D
F
V
V
E
H
D
L
I
V
I
S
D
E
V
Y
E
H
F
I
Y
D
D
-
A
-
R
-
H
Y
S
I
A
S
L
DG
M
F
--
E
---
R
T
I
T
V
N
G
F
S
K
T
F
A
M
T
G
W
R
L
G
F
V
A
A
P
S
W
I
I
E
R
M
V
K
F
Q
M
Y
N
A
T
C
P
V
T
F
I
Q
Y
A
A
A
K
A
L
-
K
D
ER----
S
-------
W
-
K
A
V
---
E
E
-----
M
R
K
E
Y
D
R
R
R
K
L
V
W
K
R
L
N
E
M
-
G
L
P
T
V
K
P
K
G
A
F
Y
I
F
P
R
I
R
D
-
T
G
------
L
-
T
-----------
S
K
K
F
S
E
L
M
L
K
E
A
R
V
A
V
V
P
G
S
A
F
-
G
K
A
-----
G
E
G
------
Y
V
R
I
S
Y
A
T
A
Y
E
K
L
E
E
A
M
D
R
M
E
R
V
L
K
E
R
2
PsiBlast_PDB
73.77
37%
-24
- C1 -
-
1GDE
4
?
A:
[3-386]
-------
L
S
D
R
L
E
L
V
S
A
S
E
I
R
K
L
F
D
I
A
A
G
M
----
K
D
V
I
S
L
G
I
G
E
P
D
F
D
T
P
Q
H
I
K
E
Y
A
K
E
A
L
D
-
K
---
G
L
T
H
Y
G
P
N
I
G
L
L
E
L
R
E
A
I
A
E
K
L
K
K
Q
N
G
I
E
A
D
P
K
T
E
I
M
V
L
L
G
A
N
Q
A
F
L
M
G
L
S
A
F
L
K
D
G
E
E
V
L
I
P
T
P
A
F
V
S
Y
A
P
A
V
I
L
A
-
G
G
K
--
P
V
E
V
P
T
Y
E
E
----------
D
---------
E
F
R
L
N
V
D
E
L
K
K
---
Y
V
T
D
K
T
----
R
A
L
I
I
N
S
P
C
N
P
T
G
A
V
L
T
K
K
D
L
E
E
I
A
D
F
V
V
E
H
D
L
I
V
I
S
D
E
V
Y
E
H
F
I
Y
D
D
-
A
-
R
-
H
Y
S
I
A
S
L
DG
M
F
--
E
---
R
T
I
T
V
N
G
F
S
K
T
F
A
M
T
G
W
R
L
G
F
V
A
A
P
S
W
I
I
E
R
M
V
K
F
Q
M
Y
N
A
T
C
P
V
T
F
I
Q
Y
A
A
A
K
A
L
-
K
D
E
R
----
S
-------
W
-
K
A
V
---
E
E
-----
M
R
K
E
Y
D
R
R
R
K
L
V
W
K
R
L
N
E
M
-
G
L
P
T
V
K
P
K
G
A
F
Y
I
F
P
R
I
R
D
-
T
G
------
L
-
T
-----------
S
K
K
F
S
E
L
M
L
K
E
A
R
V
A
V
V
P
G
S
A
F
-
G
K
A
-----
G
E
G
------
Y
V
R
I
S
Y
A
T
A
Y
E
K
L
E
E
A
M
D
R
M
E
R
V
L
K
E
R
22
PsiBlast_CBE
73.65
37%
-23
- C1 -
-
1GDE
4
?
B:
[3-386]
-------
L
S
D
R
L
E
L
V
S
A
S
E
I
R
K
L
F
D
I
A
A
G
M
----
K
D
V
I
S
L
G
I
G
E
P
D
F
D
T
P
Q
H
I
K
E
Y
A
K
E
A
L
D
-
K
---
G
L
T
H
Y
G
P
N
I
G
L
L
E
L
R
E
A
I
A
E
K
L
K
K
Q
N
G
I
E
A
D
P
K
T
E
I
M
V
L
L
G
A
N
Q
A
F
L
M
G
L
S
A
F
L
K
D
G
E
E
V
L
I
P
T
P
A
F
V
S
Y
A
P
A
V
I
L
A
-
G
G
K
--
P
V
E
V
P
T
Y
E
E
----------
D
---------
E
F
R
L
N
V
D
E
L
K
K
---
Y
V
T
D
K
T
----
R
A
L
I
I
N
S
P
C
N
P
T
G
A
V
L
T
K
K
D
L
E
E
I
A
D
F
V
V
E
H
D
L
I
V
I
S
D
E
V
Y
E
H
F
I
Y
D
D
-
A
-
R
-
H
Y
S
I
A
S
L
DG
M
F
--
E
---
R
T
I
T
V
N
G
F
S
K
T
F
A
M
T
G
W
R
L
G
F
V
A
A
P
S
W
I
I
E
R
M
V
K
F
Q
M
Y
N
A
T
C
P
V
T
F
I
Q
Y
A
A
A
K
A
L
-
K
D
ER----
S
-------
W
-
K
A
V
---
E
E
-----
M
R
K
E
Y
D
R
R
R
K
L
V
W
K
R
L
N
E
M
-
G
L
P
T
V
K
P
K
G
A
F
Y
I
F
P
R
I
R
D
-
T
G
------
L
-
T
-----------
S
K
K
F
S
E
L
M
L
K
E
A
R
V
A
V
V
P
G
S
A
F
-
G
K
A
-----
G
E
G
------
Y
V
R
I
S
Y
A
T
A
Y
E
K
L
E
E
A
M
D
R
M
E
R
V
L
K
E
R
3
PsiBlast_PDB
72.40
37%
-21
- C1 -
-
1GD9
2
?
A:
[3-386]
-------
L
S
D
R
L
E
L
V
S
A
S
E
I
R
K
L
F
D
I
A
A
G
M
----
K
D
V
I
S
L
G
I
G
E
P
D
F
D
T
P
Q
H
I
K
E
Y
A
K
E
A
L
D
-
K
---
G
L
T
H
Y
G
P
N
I
G
L
L
E
L
R
E
A
I
A
E
K
L
K
K
Q
N
G
I
E
A
D
P
K
T
E
I
M
V
L
L
G
A
N
Q
A
F
L
M
G
L
S
A
F
L
K
D
G
E
E
V
L
I
P
T
P
A
F
V
S
Y
A
P
A
V
I
L
A
-
G
G
K
--
P
V
E
V
P
T
Y
E
E
----------
D
---------
E
F
R
L
N
V
D
E
L
K
K
---
Y
V
T
D
K
T
----
R
A
L
I
I
N
S
P
C
N
P
T
G
A
V
L
T
K
K
D
L
E
E
I
A
D
F
V
V
E
H
D
L
I
V
I
S
D
E
V
Y
E
H
F
I
Y
D
D
-
A
-
R
-
H
Y
S
I
A
S
L
DG
M
F
--
E
---
R
T
I
T
V
N
G
F
S
K
T
F
A
M
T
G
W
R
L
G
F
V
A
A
P
S
W
I
I
E
R
M
V
K
F
Q
M
Y
N
A
T
C
P
V
T
F
I
Q
Y
A
A
A
K
A
L
-
K
D
E
R
----
S
-------
W
-
K
A
V
---
E
E
-----
M
R
K
E
Y
D
R
R
R
K
L
V
W
K
R
L
N
E
M
-
G
L
P
T
V
K
P
K
G
A
F
Y
I
F
P
R
I
R
D
-
T
G
------
L
-
T
-----------
S
K
K
F
S
E
L
M
L
K
E
A
R
V
A
V
V
P
G
S
A
F
-
G
K
A
-----
G
E
G
------
Y
V
R
I
S
Y
A
T
A
Y
E
K
L
E
E
A
M
D
R
M
E
R
V
L
K
E
R
1
PsiBlast_PDB
71.12
37%
-28
- C1 -
-
1DJU
2
?
A:
[2-385]
-------
L
S
D
R
L
E
L
V
S
A
-----------------
K
D
V
I
S
L
G
I
G
E
P
D
F
D
T
P
Q
H
I
K
E
Y
A
K
E
A
L
D
-
K
---
G
L
T
H
Y
G
P
N
I
G
L
L
E
L
R
E
A
I
A
E
K
L
K
K
Q
N
G
I
E
A
D
P
K
T
E
I
M
V
L
L
G
A
N
Q
A
F
L
M
G
L
S
A
F
L
K
D
G
E
E
V
L
I
P
T
P
A
F
V
S
Y
A
P
A
V
I
L
A
-
G
G
K
--
P
V
E
V
P
T
Y
E
E
----------
D
---------
E
F
R
L
N
V
D
E
L
K
K
---
Y
V
T
D
K
T
----
R
A
L
I
I
N
S
P
C
N
P
T
G
A
V
L
T
K
K
D
L
E
E
I
A
D
F
V
V
E
H
D
L
I
V
I
S
D
E
V
Y
E
H
F
I
Y
D
D
-
A
-
R
-
H
Y
S
I
A
S
L
DG
M
F
--
E
---
R
T
I
T
V
N
G
F
S
K
T
F
A
M
T
G
W
R
L
G
F
V
A
A
P
S
W
I
I
E
R
M
V
K
F
Q
M
Y
N
A
T
C
P
V
T
F
I
Q
Y
A
A
A
K
A
L
-
K
D
E
R
----
S
-------
W
-
K
A
V
---
E
E
-----
M
R
K
E
Y
D
R
R
R
K
L
V
W
K
R
L
N
E
M
-
G
L
P
T
V
K
P
K
G
A
F
Y
I
F
P
R
I
R
D
-
T
G
------
L
-
T
-----------
S
K
K
F
S
E
L
M
L
K
E
A
R
V
A
V
V
P
G
S
A
F
-
G
K
A
-----
G
E
G
------
Y
V
R
I
S
Y
A
T
A
Y
E
K
L
E
E
A
M
E
R
M
E
R
V
L
K
E
R
21
PsiBlast_CBE
71.07
37%
-30
- C1 -
-
1DJU
2
?
B:
[2-385]
-------
L
S
D
R
L
E
L
V
S
-------------------
D
V
I
S
L
G
I
G
E
P
D
F
D
T
P
Q
H
I
K
E
Y
A
K
E
A
L
D
-
K
---
G
L
T
H
Y
G
P
N
I
G
L
L
E
L
R
E
A
I
A
E
K
L
K
K
Q
N
G
I
E
A
D
P
K
T
E
I
M
V
L
L
G
A
N
Q
A
F
L
M
G
L
S
A
F
L
K
D
G
E
E
V
L
I
P
T
P
A
F
V
S
Y
A
P
A
V
I
L
A
-
G
G
K
--
P
V
E
V
P
T
Y
E
E
----------
D
---------
E
F
R
L
N
V
D
E
L
K
K
---
Y
V
T
D
K
T
----
R
A
L
I
I
N
S
P
C
N
P
T
G
A
V
L
T
K
K
D
L
E
E
I
A
D
F
V
V
E
H
D
L
I
V
I
S
D
E
V
Y
E
H
F
I
Y
D
D
-
A
-
R
-
H
Y
S
I
A
S
L
DG
M
F
--
E
---
R
T
I
T
V
N
G
F
S
K
T
F
A
M
T
G
W
R
L
G
F
V
A
A
P
S
W
I
I
E
R
M
V
K
F
Q
M
Y
N
A
T
C
P
V
T
F
I
Q
Y
A
A
A
K
A
L
-
K
D
E
R
----
S
-------
W
-
K
A
V
---
E
E
-----
M
R
K
E
Y
D
R
R
R
K
L
V
W
K
R
L
N
E
M
-
G
L
P
T
V
K
P
K
G
A
F
Y
I
F
P
R
I
R
D
-
T
G
------
L
-
T
-----------
S
K
K
F
S
E
L
M
L
K
E
A
R
V
A
V
V
P
G
S
A
F
-
G
K
A
-----
G
E
G
------
Y
V
R
I
S
Y
A
T
A
Y
E
K
L
E
E
A
M
E
R
M
E
R
V
L
K
E
R
72
HHSearch
67.52
28%
-24
- C1 -
-
3E2Y
6
KAT3_MOUSE
B:
[2-410]
--------
A
K
R
I
E
G
L
D
S
N
V
W
V
E
F
T
K
-
L
A
A
D
----
P
S
V
V
N
L
G
Q
G
F
P
D
I
S
P
P
S
Y
V
K
E
E
L
S
K
A
A
F
I
D
---
N
M
N
Q
Y
T
R
G
F
G
H
P
A
L
V
K
A
L
S
C
L
Y
G
K
I
Y
Q
R
Q
I
D
P
N
E
E
I
L
V
A
V
G
A
Y
G
S
L
F
N
S
I
Q
G
L
V
D
P
G
D
E
V
I
I
M
V
P
F
Y
D
C
Y
E
P
M
V
R
M
A
-
G
A
V
--
P
V
F
I
P
L
-
R
S
KPTDGMKWTS
S
---------
D
W
T
F
D
P
R
E
L
E
S
K
F
---
S
S
K
T
----
K
A
I
I
L
N
T
P
H
N
P
L
G
K
V
Y
T
R
Q
E
L
Q
V
I
A
D
L
C
V
K
H
D
T
L
C
I
S
D
E
V
Y
E
W
L
V
Y
-
T
-
G
-
H
T
H
V
K
I
A
T
L
PG
M
W
--
E
---
R
T
I
T
I
G
S
A
G
K
T
F
S
V
T
G
W
K
L
G
W
S
I
G
P
A
H
L
I
K
H
L
Q
T
V
Q
Q
N
S
F
Y
T
C
A
T
P
L
Q
A
A
L
A
E
A
F
W
I
D
IKRMDD
P
-------
E
-
C
Y
F
---
N
S
-----
L
P
K
E
L
E
V
K
R
D
R
M
V
R
L
L
N
S
V
-
G
L
K
P
I
V
P
D
G
G
Y
F
I
I
A
D
V
S
S
-
L
G
ADLSDM
N
-
S
DEP-------
Y
D
Y
K
F
V
K
W
M
T
K
H
K
K
L
T
A
I
P
V
S
A
F
-
C
D
S
KSKPH
F
E
K
------
L
V
R
F
C
F
I
K
K
D
S
T
L
D
A
A
E
E
I
F
R
A
W
N
---
81
HHSearch
66.97
27%
-18
- C1 -
-
2R5C
1
?
A:
[11-428]
---
N
K
F
D
L
P
K
R
Y
Q
G
S
T
K
S
V
W
V
E
Y
I
Q
-
L
A
A
Q
----
Y
K
P
L
N
L
G
Q
G
F
P
D
Y
H
A
P
K
Y
A
L
N
A
L
A
A
A
A
N
-
S
PDP
L
A
N
Q
Y
T
R
G
F
G
H
P
R
L
V
Q
A
L
S
K
L
Y
S
Q
L
V
D
R
T
I
N
P
M
T
E
V
L
V
T
V
G
A
Y
E
A
L
Y
A
T
I
Q
G
H
V
D
E
G
D
E
V
I
I
I
E
P
F
F
D
C
Y
E
P
M
V
K
A
A
-
G
G
I
--
P
R
F
I
P
L
-
K
P
----------
N
KTGGTISSA
D
W
V
L
D
N
N
E
L
E
A
L
F
---
N
E
K
T
----
K
M
I
I
I
N
T
P
H
N
P
L
G
K
V
M
D
R
A
E
L
E
V
V
A
N
L
C
K
K
W
N
V
L
C
V
S
D
E
V
Y
E
H
M
V
F
-
E
-
P
-
F
E
H
I
R
I
C
T
L
PG
M
W
--
E
---
R
T
I
T
I
G
S
A
G
K
T
F
S
L
T
G
W
K
I
G
W
A
Y
G
P
E
A
L
L
K
N
L
Q
M
V
H
Q
N
C
V
Y
T
C
A
T
P
I
Q
E
A
I
A
V
G
F
-
E
T
------
E
L
K
RLKSP
E
-
C
Y
F
---
N
S
-----
I
S
G
E
L
M
A
K
R
D
Y
M
A
S
F
L
A
E
V
-
G
M
N
P
T
V
P
Q
G
G
Y
F
M
V
A
D
W
S
S
-
L
D
------
S
-
K
VDLTQETDA
R
K
D
Y
R
F
T
K
W
M
T
K
S
V
G
L
Q
G
I
P
P
S
A
F
-
Y
S
E
PNKHL
G
E
D
------
F
V
R
Y
C
F
F
K
K
D
E
N
L
Q
K
A
A
E
I
L
R
K
W
K
G
S
-
12
PsiBlast_PDB
66.08
35%
-38
- C1 -
-
1BJW
-
AAT_THET8
A:
[32-382]
-----------------------------------
D
L
V
A
L
T
A
G
E
P
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
-
Q
---
G
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
T
P
E
-
E
T
I
V
T
V
G
G
K
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
-
G
G
V
--
V
V
E
V
E
T
L
P
E
----------
E
---------
G
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
---
T
----
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
-
E
-
G
-
E
-
H
F
S
P
G
R
V
--
A
P
--
E
---
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
S
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
-
T
N
------
Q
-------
E
-
A
S
R
A
F
V
E
M
-----
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
-
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
T
-
S
-
P
I
------
A
-
P
----------
D
E
V
R
A
A
E
R
L
L
E
-
A
G
V
A
V
V
P
G
T
D
F
-
A
-------
A
F
G
------
H
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
---
9
PsiBlast_PDB
65.81
35%
-37
- C1 -
-
5BJ4
2
AAT_THET8
A:
[32-382]
-----------------------------------
D
L
V
A
L
T
A
G
E
P
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
-
Q
---
G
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
T
P
E
-
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
-
G
G
V
--
V
V
E
V
E
T
L
P
E
----------
E
---------
G
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
---
T
----
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
-
E
-
G
-
E
-
H
F
S
P
G
R
V
--
A
P
--
E
---
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
R
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
-
T
N
------
Q
-------
E
-
A
S
R
A
F
V
E
M
-----
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
-
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
T
-
S
-
P
I
------
A
-
P
----------
D
E
V
R
A
A
E
R
L
L
E
-
A
G
V
A
V
V
P
G
T
D
F
-
A
-------
A
F
G
------
H
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
---
38
PsiBlast_CBE
65.55
35%
-39
- C1 -
-
1B5O
2
AAT_THET8
B:
[32-382]
-----------------------------------
D
L
V
A
L
T
A
G
E
P
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
-
Q
---
G
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
T
P
E
-
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
-
G
G
V
--
V
V
E
V
E
T
L
P
E
----------
E
---------
G
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
---
T
----
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
-
E
-
G
-
E
-
H
F
S
P
G
R
V
--
A
P
--
E
---
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
S
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
-
T
N
------
Q
-------
E
-
A
S
R
AFV
E
M
-----
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
-
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
T
-
S
-
P
I
------
A
-
P
----------
D
E
V
R
A
A
E
R
L
L
E
-
A
G
V
A
V
V
P
G
T
D
F
-
A
-------
A
F
G
------
H
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
---
6
PsiBlast_PDB
65.20
35%
-36
- C1 -
-
1B5P
2
AAT_THET8
A:
[32-382]
-----------------------------------
D
L
V
A
L
T
A
G
E
P
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
-
Q
---
G
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
T
P
E
-
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
-
G
G
V
--
V
V
E
V
E
T
L
P
E
----------
E
---------
G
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
---
T
----
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
-
E
-
G
-
E
-
H
F
S
P
G
R
V
--
A
P
--
E
---
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
R
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
-
T
N
------
Q
-------
E
-
A
S
R
A
F
V
E
M
-----
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
-
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
T
-
S
-
P
I
------
A
-
P
----------
D
E
V
R
A
A
E
R
L
L
E
-
A
G
V
A
V
V
P
G
T
D
F
-
A
-------
A
F
G
------
H
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
---
10
PsiBlast_PDB
65.19
35%
-38
- C1 -
-
1B5O
2
AAT_THET8
A:
[32-382]
-----------------------------------
D
L
V
A
L
T
A
G
E
P
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
-
Q
---
G
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
T
P
E
-
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
-
G
G
V
--
V
V
E
V
E
T
L
P
E
----------
E
---------
G
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
---
T
----
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
-
E
-
G
-
E
-
H
F
S
P
G
R
V
--
A
P
--
E
---
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
S
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
-
T
N
------
Q
-------
E
-
A
S
R
A
F
V
E
M
-----
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
-
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
T
-
S
-
P
I
------
A
-
P
----------
D
E
V
R
A
A
E
R
L
L
E
-
A
G
V
A
V
V
P
G
T
D
F
-
A
-------
A
F
G
------
H
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
---
27
PsiBlast_CBE
65.18
35%
-39
- C1 -
-
5BJ4
2
AAT_THET8
B:
[32-382]
-----------------------------------
D
L
V
A
L
T
A
G
E
P
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
-
Q
---
G
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
T
P
E
-
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
-
G
G
V
--
V
V
E
V
E
T
L
P
E
----------
E
---------
G
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
---
T
----
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
-
E
-
G
-
E
-
H
F
S
P
G
R
V
--
A
P
--
E
---
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
R
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
-
T
N
------
Q
-------
E
-
A
S
R
AFV
E
M
-----
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
-
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
T
-
S
-
P
I
------
A
-
P
----------
D
E
V
R
A
A
E
R
L
L
E
-
A
G
V
A
V
V
P
G
T
D
F
-
A
-------
A
F
G
------
H
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
---
11
PsiBlast_PDB
64.89
35%
-38
- C1 -
-
1BKG
4
AAT_THET8
A:
[32-382]
-----------------------------------
D
L
V
A
L
T
A
G
E
P
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
-
Q
---
G
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
T
P
E
-
E
T
I
V
T
V
G
G
K
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
-
G
G
V
--
V
V
E
V
E
T
L
P
E
----------
E
---------
G
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
---
T
----
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
-
E
-
G
-
E
-
H
F
S
P
G
R
V
--
A
P
--
E
---
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
S
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
-
T
N
------
Q
-------
E
-
A
S
R
A
F
V
E
M
-----
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
-
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
T
-
S
-
P
I
------
A
-
P
----------
D
E
V
R
A
A
E
R
L
L
E
-
A
G
V
A
V
V
P
G
T
D
F
-
A
-------
A
F
G
------
H
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
---
40
PsiBlast_CBE
64.79
35%
-40
- C1 -
-
1BKG
3
AAT_THET8
C:
[32-382]
-----------------------------------
D
L
V
A
L
T
A
G
E
P
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
-
Q
---
G
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
T
P
E
-
E
T
I
V
T
V
G
G
K
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
-
G
G
V
--
V
V
E
V
E
T
L
P
E
----------
E
---------
G
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
---
T
----
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
-
E
-
G
-
E
-
H
F
S
P
G
R
V
--
A
P
--
E
---
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
S
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
-
T
N
------
Q
-------
E
-
A
S
R
AFV
E
M
-----
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
-
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
T
-
S
-
P
I
------
A
-
P
----------
D
E
V
R
A
A
E
R
L
L
E
-
A
G
V
A
V
V
P
G
T
D
F
-
A
-------
A
F
G
------
H
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
---
39
PsiBlast_CBE
64.72
35%
-39
- C1 -
-
1BKG
3
AAT_THET8
D:
[32-382]
-----------------------------------
D
L
V
A
L
T
A
G
E
P
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
-
Q
---
G
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
T
P
E
-
E
T
I
V
T
V
G
G
K
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
-
G
G
V
--
V
V
E
V
E
T
L
P
E
----------
E
---------
G
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
---
T
----
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
-
E
-
G
-
E
-
H
F
S
P
G
R
V
--
A
P
--
E
---
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
S
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
-
T
N
------
Q
-------
E
-
A
S
R
AFV
E
M
-----
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
-
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
T
-
S
-
P
I
------
A
-
P
----------
D
E
V
R
A
A
E
R
L
L
E
-
A
G
V
A
V
V
P
G
T
D
F
-
A
-------
A
F
G
------
H
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
---
14
PsiBlast_PDB
64.70
34%
-50
- C1 -
-
2Z61
-
MFNC_METJA
A:
[31-369]
------------------------------------
V
I
H
L
E
I
G
E
P
D
F
N
T
P
K
P
I
V
D
E
G
I
K
S
L
K
-
E
---
G
K
T
H
Y
T
D
S
R
G
I
L
E
L
R
E
K
I
S
E
L
Y
K
D
K
Y
K
A
D
I
I
P
D
N
-
I
I
I
T
G
G
S
S
L
G
L
F
F
A
L
S
S
I
I
D
D
G
D
E
V
L
I
Q
N
P
C
Y
P
C
Y
K
N
F
I
R
F
L
-
G
A
K
--
P
V
F
C
D
F
-
T
--------------------------
V
E
S
L
E
E
A
L
---
S
D
K
T
----
K
A
I
I
I
N
S
P
S
N
P
L
G
E
V
I
D
----
R
E
I
Y
E
F
A
Y
E
N
I
P
Y
I
I
S
D
E
I
Y
N
G
L
V
Y
-
E
-
G
-
K
-
C
Y
S
A
I
E
F
--
D
E
NL
E
---
K
T
I
L
I
N
G
F
S
K
L
Y
A
M
T
G
W
R
I
G
Y
V
I
S
N
D
E
I
I
E
A
I
L
K
L
Q
Q
N
L
F
I
S
A
P
T
I
S
Q
Y
A
A
L
K
A
F
-
E
K
------
E
-------
T
E
R
E
I
---
N
S
-----
M
I
K
E
F
D
R
R
R
R
L
V
L
K
Y
V
K
D
F
-
G
W
E
V
N
N
P
I
G
A
Y
Y
V
F
----
P
-
N
I
------
G
-
E
----------
D
G
R
E
F
A
Y
K
L
L
K
E
K
F
V
A
L
T
P
G
I
G
F
-
G
S
K
-----
G
K
N
------
Y
I
R
I
S
Y
A
N
S
Y
E
N
I
K
E
G
L
E
R
I
K
E
F
L
N
--
26
PsiBlast_CBE
63.83
35%
-41
- C1 -
-
1B5P
2
AAT_THET8
B:
[32-382]
-----------------------------------
D
L
V
A
L
T
A
G
E
P
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
-
Q
---
G
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
T
P
E
-
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
-
G
G
V
--
V
V
E
V
E
T
L
P
E
----------
E
---------
G
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
---
T
----
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
-
E
-
G
-
E
-
H
F
S
P
G
R
V
--
A
P
--
E
---
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
R
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
-
T
N
------
Q
-------
E
-
A
S
R
AFV
E
M
-----
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
-
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
T
-
S
-
P
I
------
A
-
P
----------
D
E
V
R
A
A
E
R
L
L
E
-
A
G
V
A
V
V
P
G
T
D
F
-
A
-------
A
F
G
------
H
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
---
42
PsiBlast_CBE
63.68
35%
-23
- C1 -
-
1J32
2
?
B:
[31-384]
-----------------------------------
D
V
C
S
F
S
A
G
E
P
D
F
N
T
P
K
H
I
V
E
A
A
K
A
A
L
E
-
Q
---
G
K
T
R
Y
G
P
A
A
G
E
P
R
L
R
E
A
I
A
Q
K
L
Q
R
D
N
G
L
C
Y
G
A
D
N
-
I
L
V
T
N
G
G
K
Q
S
I
F
N
L
M
L
A
M
I
E
P
G
D
E
V
I
I
P
A
P
F
W
V
S
Y
P
E
M
V
K
L
A
E
G
T
P
--
V
I
L
P
T
T
-
V
E
----------
T
---------
Q
F
K
V
S
P
E
Q
I
R
Q
A
I
T
---
P
K
T
----
K
L
L
V
F
N
T
P
S
N
P
T
G
M
V
Y
T
P
D
E
V
R
A
I
A
Q
V
A
V
E
A
G
L
W
V
L
S
D
E
I
Y
E
K
I
L
Y
-
D
D
A
-
Q
-
H
L
S
I
G
A
A
--
S
P
--
E
AYE
R
S
V
V
C
S
G
F
A
K
T
Y
A
M
T
G
W
R
V
G
F
L
A
G
P
V
P
L
V
K
A
A
T
K
I
Q
G
H
S
T
S
N
V
C
T
F
A
Q
Y
G
A
I
A
A
Y
-
E
N
------
S
-------
Q
-
D
C
V
---
Q
E
-----
M
L
A
A
F
A
E
R
R
R
Y
M
L
D
A
L
N
A
M
P
G
L
E
C
P
K
P
D
G
A
F
Y
M
F
P
S
I
-
A
-
K
T
------
G
-
R
----------
S
S
L
D
F
C
S
E
L
L
D
Q
H
Q
V
A
T
V
P
G
A
A
F
-
G
-------
A
D
D
------
C
I
R
L
S
Y
A
T
D
L
D
T
I
K
R
G
M
E
R
L
E
K
F
L
---
24
PsiBlast_CBE
63.56
34%
-2
- C1 -
-
1O4S
2
AAT_THEMA
B:
[15-388]
--------
S
R
R
I
S
E
I
P
I
S
K
T
M
E
L
D
A
K
A
K
A
L
I
K
K
G
E
D
V
I
N
L
T
A
G
E
P
D
F
P
T
P
E
P
V
V
E
E
A
V
R
F
L
Q
-
K
---
G
E
V
K
Y
T
D
P
R
G
I
Y
E
L
R
E
G
I
A
K
R
I
G
E
R
Y
K
K
D
I
S
P
D
-
Q
V
V
V
T
N
G
A
K
Q
A
L
F
N
A
F
M
A
L
L
D
P
G
D
E
V
I
V
F
S
P
V
W
V
S
Y
I
P
Q
I
I
L
A
-
G
G
T
--
V
N
V
V
E
T
--------------------------
F
M
S
K
N
F
Q
P
S
L
E
E
V
E
G
L
L
VGKT
K
A
V
L
I
N
S
P
N
N
P
T
G
V
V
Y
R
R
E
F
L
E
G
L
V
R
L
A
K
K
R
N
F
Y
I
I
S
D
E
V
Y
D
S
L
V
Y
-
T
-
D
-
E
-
F
T
S
I
L
D
V
--
S
E
GF
D
---
R
I
V
Y
I
N
G
F
S
K
S
H
S
M
T
G
W
R
V
G
Y
L
I
S
S
E
K
V
A
T
A
V
S
K
I
Q
S
H
T
T
S
C
I
N
T
V
A
Q
Y
A
A
L
K
A
L
-----------------
E
-
V
D
N
---
S
Y
-----
M
V
Q
T
F
K
E
R
K
N
F
V
V
E
R
L
K
K
M
-
G
V
K
F
V
E
P
E
G
A
F
Y
L
F
F
K
-----
V
------
R
-
G
----------
D
D
V
K
F
C
E
R
L
L
E
E
K
K
V
A
L
V
P
G
S
A
F
L
K
P
--------
G
------
F
V
R
L
S
F
A
T
S
I
E
R
L
T
E
A
L
D
R
I
E
D
F
L
N
S
-
13
PsiBlast_PDB
62.26
35%
-20
- C1 -
-
1J32
2
?
A:
[31-384]
-----------------------------------
D
V
C
S
F
S
A
G
E
P
D
F
N
T
P
K
H
I
V
E
A
A
K
A
A
L
E
-
Q
---
G
K
T
R
Y
G
P
A
A
G
E
P
R
L
R
E
A
I
A
Q
K
L
Q
R
D
N
G
L
C
Y
G
A
D
N
-
I
L
V
T
N
G
G
K
Q
S
I
F
N
L
M
L
A
M
I
E
P
G
D
E
V
I
I
P
A
P
F
W
V
S
Y
P
E
M
V
K
L
A
E
G
T
P
--
V
I
L
P
T
T
-
V
E
----------
T
---------
Q
F
K
V
S
P
E
Q
I
R
Q
A
I
T
---
P
K
T
----
K
L
L
V
F
N
T
P
S
N
P
T
G
M
V
Y
T
P
D
E
V
R
A
I
A
Q
V
A
V
E
A
G
L
W
V
L
S
D
E
I
Y
E
K
I
L
Y
-
D
D
A
-
Q
-
H
L
S
I
G
A
A
--
S
P
--
E
A
Y
E
R
S
V
V
C
S
G
F
A
K
T
Y
A
M
T
G
W
R
V
G
F
L
A
G
P
V
P
L
V
K
A
A
T
K
I
Q
G
H
S
T
S
N
V
C
T
F
A
Q
Y
G
A
I
A
A
Y
-
E
N
------
S
-------
Q
-
D
C
V
---
Q
E
-----
M
L
A
A
F
A
E
R
R
R
Y
M
L
D
A
L
N
A
M
P
G
L
E
C
P
K
P
D
G
A
F
Y
M
F
P
S
I
-
A
-
K
T
------
G
-
R
----------
S
S
L
D
F
C
S
E
L
L
D
Q
H
Q
V
A
T
V
P
G
A
A
F
-
G
-------
A
D
D
------
C
I
R
L
S
Y
A
T
D
L
D
T
I
K
R
G
M
E
R
L
E
K
F
L
---
25
PsiBlast_CBE
62.21
35%
-35
- C1 -
-
1GCK
4
AAT_THET8
B:
[32-382]
-----------------------------------
D
L
V
A
L
T
A
G
E
P
D
F
D
T
P
E
H
V
K
E
A
A
R
R
A
L
A
-
Q
---
G
K
T
K
Y
A
P
P
A
G
I
P
E
L
R
E
A
L
A
E
K
F
R
R
E
N
G
L
S
V
T
P
E
-
E
T
I
V
T
V
G
G
S
Q
A
L
F
N
L
F
Q
A
I
L
D
P
G
D
E
V
I
V
L
S
P
Y
W
V
S
Y
P
E
M
V
R
F
A
-
G
G
V
--
V
V
E
V
E
T
L
P
E
----------
E
---------
G
F
V
P
D
P
E
R
V
R
R
A
I
T
P
R
---
T
----
K
A
L
V
V
N
S
P
N
N
P
T
G
A
V
Y
P
K
E
V
L
E
A
L
A
R
L
A
V
E
H
D
F
Y
L
V
S
D
E
I
Y
E
H
L
L
Y
-
E
-
G
-
E
-
H
F
S
P
G
R
V
--
A
P
--
E
---
H
T
L
T
V
N
G
A
A
K
A
F
A
M
T
G
W
R
I
G
Y
A
C
G
P
K
E
V
I
K
A
M
A
S
V
S
R
Q
S
T
T
S
P
D
T
I
A
Q
W
A
T
L
E
A
L
-
T
N
------
Q
-------
E
-
A
S
R
AFV
E
M
-----
A
R
E
A
Y
R
R
R
R
D
L
L
L
E
G
L
T
A
L
-
G
L
K
A
V
R
P
S
G
A
F
Y
V
L
M
D
T
-
S
-
P
I
------
A
-
P
----------
D
E
V
R
A
A
E
R
L
L
E
-
A
G
V
A
V
V
P
G
T
D
F
-
A
-------
A
F
G
------
H
V
R
L
S
Y
A
T
S
E
E
N
L
R
K
A
L
E
R
F
A
R
V
L
---
18
PsiBlast_PDB
54.39
33%
-22
- C1 -
-
2O0R
2
DAPC_MYCTU
A:
[28-390]
-------------------------------------
V
N
L
G
Q
G
F
P
D
E
D
G
P
P
K
M
L
Q
A
A
Q
D
A
I
A
-
G
---
G
V
N
Q
Y
P
P
G
P
G
S
A
P
L
R
R
A
I
A
A
Q
R
R
R
H
F
G
V
D
Y
D
P
E
T
E
V
L
V
T
V
G
A
T
E
A
I
A
A
A
V
L
G
L
V
E
P
G
S
E
V
L
L
I
E
P
F
Y
D
S
Y
S
P
V
V
A
M
A
-
G
A
H
R
V
T
V
P
L
V
P
-
D
G
----------
R
---------
G
F
A
L
D
A
D
A
L
R
R
A
V
T
P
R
---
T
----
R
A
L
I
I
N
S
P
H
N
P
T
G
A
V
L
S
A
T
E
L
A
A
I
A
E
I
A
V
A
A
N
L
V
V
I
T
D
E
V
Y
E
H
L
V
F
-
D
H
A
-
R
-
H
L
P
L
A
G
F
DG
M
A
--
E
---
R
T
I
T
I
S
S
A
A
K
M
F
N
C
T
G
W
K
I
G
W
A
C
G
P
A
E
L
I
A
G
V
R
A
A
K
Q
Y
L
S
Y
V
G
G
A
P
F
Q
P
A
V
A
L
A
L
--------------------
D
T
---
E
D
A
W
V
A
A
L
R
N
S
L
R
A
R
R
D
R
L
A
A
G
L
T
E
I
-
G
F
A
V
H
D
S
Y
G
T
Y
F
L
-
C
A
D
P
R
-
P
L
------
G
Y
D
----------
D
S
T
E
F
C
A
A
L
P
E
K
V
G
V
A
A
I
P
M
S
A
F
-
C
D
P
--------ADVWN
H
L
V
R
F
T
F
C
K
R
D
D
T
L
D
E
A
I
R
R
L
S
------