@TOME V2.3
(Mar 2018)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Q3Y2J2: (2018-01-31 )
MINLGIIGTNWITHQFVQAALSTKKYELTAVYSRHLEKAQEFGSHYEGDIEFATDLKTFFNITHMDTIYIASPNSLHFSQAKQAILAGKNVIVEKPAFSTPKEMDEIIHLANEHNVYFFEAARNIHESGFKKIADYLPLKDEIIGANFSYMKYSSRYDQVLDGEEPNIFSTHFSGGALMDLGVYLVYAAVAWFGMPKEVHYFPRKISTGVDGLGWGILRYENFDVSIQPGKIGDSYLPSEIYFDSGTLVMNGVNAIEQAQFHDRAHKEIIDLAVTAAENPMADEAEDFANVMAHPKDPAWGLLYEEWIELARNVNQVIYDLRKNGGIKFDADNEEDF
Atome Classification :
(20 SA)
.......-..10...-..-...--20...--.....30........40.....--...50........60........70........80........90........-100.......110......-.120........130......--.----140.......150.......160-.......170-.......180.......190..--.--....200.--...---...210.......220-.-......230..------...-..240.......250.-----..-.-----.-..260-----------.....-------.-------.270..---.......280.......290..-.....300.....----..310.......320.......330.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
I
N
L
G
I
I-GT
N
W
I
T
H
-
Q
F
-
V
Q
A
--
A
LSTK--
K
Y
E
L
T
A
V
Y
S
R
H
L
E
K
A
Q
E
F
GSHY--EGD
I
E
F
A
T
D
L
K
T
F
FNI
T
H
M
D
T
I
Y
IASPNSL
H
F
S
Q
A
K
Q
A
I
LAGK
N
V
I
V
EKPAFS-
T
P
K
E
M
D
E
I
I
H
LANEH
N
V
Y
F
-
F
E
A
-
A
R
N
I
H
E
S
G
F
K
K
I
A
D
YLP--L----
K
D
E
IIGAN
F
S
Y
M
KYS
S
R
Y
D
Q
VLD-GEEP
N
I
F
S
TH-FSG
G
A
L
M
D
L
G
V
Y
L
V
Y
A
A
V
A
W
FG--M--P
K
E
V
H
YF
P
--
R
K
I
---STGVDGL
G
W
G
I
L
R
Y
EN-
F
-
D
V
S
IQPGKIGD------SYL-PS
E
I
Y
FDSG
T
L
V
MN
G
V
-----
N
A
-
I
-----
E
-
Q
A
Q
F
H
-----------
D
R
A
H
K
-------
E
-------
I
I
--
D
L
---
A
V
TAAENPMA
D
E
A
E
D
F
A
N
V
MAH-PKDP
A
W
G
L
L
Y
E
E
W
----
I
E
L
A
R
N
V
N
Q
V
I
Y
D
L
R
KNG
G
I
K
FDADNEEDF
1
PsiBlast_PDB
82.47
42%
-116
* C1 *
-
4NHE
5
?
A:
[4-327]
M
L
K
L
G
V
I
-
G
T
G
A
I
S
H
-
H
F
-
I
E
A
--
A
H
T
S
G
--
E
Y
Q
L
V
A
I
Y
S
R
K
L
E
T
A
A
T
F
A
S
R
Y
--
Q
-
N
I
Q
L
F
D
Q
L
E
V
F
F
K
-
S
S
F
D
L
V
Y
I
A
S
P
N
S
L
H
F
A
Q
A
K
A
A
L
S
A
G
K
H
V
I
L
E
K
P
A
V
S
-
Q
P
Q
E
W
F
D
L
I
Q
T
A
E
K
N
N
C
F
I
-
F
E
A
-
A
R
N
Y
H
E
K
A
F
T
T
I
K
N
F
L
A
--
D
----
K
-
Q
V
L
G
A
D
F
N
Y
A
K
Y
S
S
K
M
P
D
L
L
A
-
G
Q
T
P
N
V
F
S
D
R
-
F
A
G
G
A
L
M
D
L
G
I
Y
P
L
Y
A
A
V
R
L
F
G
--
K
--
A
N
D
A
T
Y
H
A
--
Q
Q
L
---
D
N
S
I
D
L
N
G
D
G
I
L
F
Y
P
D
-
Y
-
Q
V
H
I
K
A
G
K
N
I
T
------
S
N
L
-
P
C
E
I
Y
T
T
D
G
T
L
T
L
N
T
I
-----
E
H
-
I
-----
R
-
S
A
I
F
T
-----------
D
H
Q
G
N
-------
Q
--------
V
--
Q
L
---
P
I
Q
Q
A
P
H
T
M
T
E
E
V
A
A
F
A
H
M
I
Q
Q
-
P
D
L
N
----
L
Y
Q
T
W
----
L
Y
D
A
G
S
V
H
E
L
L
Y
T
M
R
Q
T
A
G
I
R
F
E
A
E
-----
21
PsiBlast_CBE
82.12
42%
-117
- C1 -
-
4NHE
12
?
C:
[4-327]
M
L
K
L
G
V
I
-
G
T
G
A
I
S
H
-
H
F
-
I
E
A
--
A
H
T
S
G
--
E
Y
Q
L
V
A
I
Y
S
R
K
L
E
T
A
A
T
F
A
S
R
Y
--
Q
-
N
I
Q
L
F
D
Q
L
E
V
F
F
K
-
S
S
F
D
L
V
Y
I
A
S
P
N
S
L
H
F
A
Q
A
K
A
A
L
S
A
G
K
H
V
I
L
E
K
P
A
V
S
-
Q
P
Q
E
W
F
D
L
I
Q
T
A
E
K
N
N
C
F
I
-
F
E
A
-
A
R
N
Y
H
E
K
A
F
T
T
I
K
N
F
L
A
--
D
----
K
-
Q
V
L
G
A
D
F
N
Y
A
K
Y
S
S
K
M
P
D
L
L
A
-
G
Q
T
P
N
V
F
S
D
R
-
F
A
G
G
A
L
M
D
L
G
I
Y
P
L
Y
A
A
V
R
L
F
G
--
K
--
A
N
D
A
T
Y
H
A
--
Q
Q
L
---
D
N
S
I
D
L
N
G
D
G
I
L
F
Y
P
D
-
Y
-
Q
V
H
I
K
A
G
K
N
I
T
------
S
N
L
-
P
C
E
I
Y
T
T
D
G
T
L
T
L
N
T
I
-----
E
H
-
I
-----
R
-
S
A
I
F
T
-----------
D
H
Q
G
N
-------
Q
--------
V
--
Q
L
---
P
I
Q
Q
A
P
H
T
M
T
E
E
V
A
A
F
A
H
M
I
Q
Q
-
P
D
L
N
----
L
Y
Q
T
W
----
L
Y
D
A
G
S
V
H
E
L
L
Y
T
M
R
Q
T
A
G
I
R
F
E
A
E
-----
22
PsiBlast_CBE
81.25
42%
-116
- C1 -
-
4NHE
8
?
B:
[4-327]
M
L
K
L
G
V
I
-
G
T
G
A
I
S
H
-
H
F
-
I
E
A
--
A
H
T
S
G
--
E
Y
Q
L
V
A
I
Y
S
R
K
L
E
T
A
A
T
F
A
S
R
Y
--
Q
-
N
I
Q
L
F
D
Q
L
E
V
F
F
K
-
S
S
F
D
L
V
Y
I
A
S
P
N
S
L
H
F
A
Q
A
K
A
A
L
S
A
G
K
H
V
I
L
E
K
P
A
V
S
-
Q
P
Q
E
W
F
D
L
I
Q
T
A
E
K
N
N
C
F
I
-
F
E
A
-
A
R
N
Y
H
E
K
A
F
T
T
I
K
N
F
L
A
--
D
----
K
-
Q
V
L
G
A
D
F
N
Y
A
K
Y
S
S
K
M
P
D
L
L
A
-
G
Q
T
P
N
V
F
S
D
R
-
F
A
G
G
A
L
M
D
L
G
I
Y
P
L
Y
A
A
V
R
L
F
G
--
K
--
A
N
D
A
T
Y
H
A
--
Q
Q
L
---
D
N
S
I
D
L
N
G
D
G
I
L
F
Y
P
D
-
Y
-
Q
V
H
I
K
A
G
K
N
I
T
------
S
N
L
-
P
C
E
I
Y
T
T
D
G
T
L
T
L
N
T
I
-----
E
H
-
I
-----
R
-
S
A
I
F
T
-----------
D
H
Q
G
N
-------
Q
--------
V
--
Q
L
---
P
I
Q
Q
A
P
H
T
M
T
E
E
V
A
A
F
A
H
M
I
Q
Q
-
P
D
L
N
----
L
Y
Q
T
W
----
L
Y
D
A
G
S
V
H
E
L
L
Y
T
M
R
Q
T
A
G
I
R
F
E
A
E
-----
2
PsiBlast_PDB
76.98
41%
-130
- C- -
-
2HO5
-
?
A:
[2-323]
-
L
K
L
G
V
I
-
G
T
G
A
I
S
H
-
H
F
-
I
E
A
--
A
H
T
S
G
--
E
Y
Q
L
V
A
I
Y
S
R
K
L
E
T
A
A
T
F
A
S
R
Y
--
Q
-
N
I
Q
L
F
D
Q
L
E
V
F
F
K
-
S
S
F
D
L
V
Y
I
A
S
P
N
S
L
H
F
A
Q
A
K
A
A
L
S
A
G
K
H
V
I
L
E
K
P
A
V
S
-
Q
P
Q
E
W
F
D
L
I
Q
T
A
E
K
N
N
C
F
I
-
F
E
A
-
A
R
N
Y
H
E
K
A
F
T
T
I
K
N
F
L
A
--
D
----
K
-
Q
V
L
G
A
D
F
N
Y
A
K
Y
S
S
K
--------------------
G
G
A
L
M
D
L
G
I
Y
P
L
Y
A
A
V
R
L
F
G
--
K
--
A
N
D
A
T
Y
H
A
--
Q
Q
L
---
D
N
S
I
D
L
N
G
D
G
I
L
F
Y
P
D
-
Y
-
Q
V
H
I
K
A
G
K
N
I
T
------
S
N
L
-
P
C
E
I
Y
T
T
D
G
T
L
T
L
N
T
I
-----
E
H
-
I
-----
R
-
S
A
I
F
T
-----------
D
H
Q
G
N
-------
Q
--------
V
--
Q
L
---
P
I
Q
Q
A
P
H
T
M
T
E
E
V
A
A
F
A
H
M
I
Q
Q
-
P
D
L
N
----
L
Y
Q
T
W
----
L
Y
D
A
G
S
V
H
E
L
L
Y
T
M
R
Q
T
A
G
I
R
F
E
A
------
52
HHSearch
72.61
40%
-66
- C1 -
-
4NHE
8
?
B:
[4-327]
M
L
K
L
G
V
I
-
G
T
G
A
I
S
H
-
H
F
-
I
E
A
--
A
H
T
S
G
--
E
Y
Q
L
V
A
I
Y
S
R
K
L
E
T
A
A
T
F
A
S
R
Y
--
Q
N
-
I
Q
L
F
D
Q
L
E
V
F
F
K
-
S
S
F
D
L
V
Y
I
A
S
P
N
S
L
H
F
A
Q
A
K
A
A
L
S
A
G
K
H
V
I
L
E
K
P
A
V
S
-
Q
P
Q
E
W
F
D
L
I
Q
T
A
E
K
N
N
C
F
I
-
F
E
A
-
A
R
N
Y
H
E
K
A
F
T
T
I
K
N
F
L
A
DK
Q
----
V
L
G
A
D
F
N
Y
A
K
Y
S
S
K
M
P
---
D
L
L
A
G
Q
T
P
N
V
F
S
D
-
R
-
F
A
G
G
A
L
M
D
L
G
I
Y
P
L
Y
A
A
V
R
L
F
G
--
K
--
A
N
D
A
T
Y
H
A
--
Q
Q
L
---
D
N
S
I
D
L
N
G
D
G
I
L
F
Y
P
D
-
Y
-
Q
V
H
I
K
A
G
K
N
I
T
------
S
N
L
-
P
C
E
I
Y
T
T
D
G
T
L
T
L
N
T
I
-----
E
H
-
I
-----
R
-
S
A
I
F
T
-----------
D
H
Q
G
N
---------------
Q
V
--
Q
L
---
P
I
Q
Q
A
P
H
T
M
T
E
E
V
A
A
F
A
H
M
I
Q
Q
-
P
D
L
----
N
L
Y
Q
T
W
----
L
Y
D
A
G
S
V
H
E
L
L
Y
T
M
R
Q
T
A
G
I
R
F
E
A
E
-----
55
HHSearch
48.32
20%
-65
- C1 -
-
3E9M
-
?
A:
[3-321]
K
I
R
Y
G
I
M
-
S
T
A
Q
I
V
P
-
R
F
-
V
A
G
--
L
R
E
S
A
--
Q
A
E
V
R
G
I
A
S
R
R
L
E
N
A
Q
K
M
A
K
E
L
--
A
I
-
P
V
A
Y
G
S
Y
E
E
L
C
K
D
E
T
I
D
I
I
Y
I
P
T
Y
N
Q
G
H
Y
S
A
A
K
L
A
L
S
Q
G
K
P
V
L
L
E
K
P
F
T
L
-
N
A
A
E
A
E
E
L
F
A
I
A
Q
E
Q
G
V
F
L
-
M
E
A
-
Q
K
S
V
F
L
P
I
T
Q
K
V
K
A
T
I
Q
E
G
G
----
L
G
E
I
L
W
V
Q
S
V
T
A
Y
P
N
V
--------
D
H
I
P
W
F
Y
S
R
E
-
A
G
G
G
A
L
H
G
S
G
S
Y
P
L
Q
Y
L
Q
Y
V
L
G
--
K
E-
I
Q
E
V
T
G
T
A
--
T
Y
Q
---
Q
G
A
T
D
S
Q
C
N
L
A
L
K
F
A
E
-
G
T
L
G
N
I
F
I
N
V
G
L
K
------
I
P
S
-
E
M
T
I
C
G
T
K
G
Q
I
V
I
P
N
F
-----
W
K
-
T
-----
D
-
C
A
Y
Y
T
-----------
D
A
Q
G
N
---------------
T
V
--
K
W
---
S
-
E
Q
F
T
S
E
F
T
Y
E
I
N
H
V
N
Q
C
L
Q
D
-
K
K
L
----
T
S
P
V
M
T
----
K
E
L
T
I
A
T
V
K
I
V
E
S
F
Y
Q
E
W
F
D
N
E
--------
54
HHSearch
47.93
20%
-66
- C1 -
-
3E9M
-
?
D:
[3-320]
K
I
R
Y
G
I
M
-
S
T
A
Q
I
V
P
-
R
F
-
V
A
G
--
L
R
E
S
A
--
Q
A
E
V
R
G
I
A
S
R
R
L
E
N
A
Q
K
M
A
K
E
L
--
A
I
-
P
V
A
Y
G
S
Y
E
E
L
C
K
D
E
T
I
D
I
I
Y
I
P
T
Y
N
Q
G
H
Y
S
A
A
K
L
A
L
S
Q
G
K
P
V
L
L
E
K
P
F
T
L
-
N
A
A
E
A
E
E
L
F
A
I
A
Q
E
Q
G
V
F
L
-
M
E
A
-
Q
K
S
V
F
L
P
I
T
Q
K
V
K
A
T
I
Q
EG
G
----
L
G
E
I
L
W
V
Q
S
V
T
A
Y
P
N
V
--------
D
H
I
P
W
F
Y
S
R
E
-
A
G
G
G
A
L
H
G
S
G
S
Y
P
L
Q
Y
L
Q
Y
V
L
G
--
K
E-
I
Q
E
V
T
G
T
A
--
T
Y
Q
---
Q
G
A
T
D
S
Q
C
N
L
A
L
K
F
A
E
-
G
T
L
G
N
I
F
I
N
V
G
L
K
------
I
P
S
-
E
M
T
I
C
G
T
K
G
Q
I
V
I
P
N
F
-----
W
K
-
T
-----
D
-
C
A
Y
Y
T
-----------
D
A
Q
G
N
---------------
T
V
--
K
W
---
S
-
E
Q
F
T
S
E
F
T
Y
E
I
N
H
V
N
Q
C
L
Q
D
-
K
K
L
----
T
S
P
V
M
T
----
K
E
L
T
I
A
T
V
K
I
V
E
S
F
Y
Q
E
W
F
D
N
---------
56
HHSearch
47.67
18%
-20
- C1 -
-
4KOA
1
AFR_RHIME
A:
[1-333]
M
I
R
W
G
L
I
-
G
A
S
T
I
A
R
-
E
W
V
I
G
A
--
I
R
A
-
A
--
G
G
E
V
V
S
V
M
S
S
S
A
E
R
G
E
A
Y
A
A
E
N
--
G
I
-
A
K
A
V
T
S
V
D
D
L
V
G
D
P
D
V
D
A
V
Y
I
S
T
T
N
E
L
H
H
G
Q
A
L
A
A
I
R
A
G
K
H
V
L
C
E
K
P
L
A
M
-
N
L
N
D
G
C
E
M
V
L
K
A
C
E
A
G
V
V
L
-
G
T
N
-
H
H
L
R
N
A
A
T
H
R
A
M
R
E
A
I
A
A
G
R
----
I
G
R
P
I
A
A
R
V
F
H
A
V
Y
L
P
P
-------
H
L
Q
G
W
R
L
D
K
P
E
A
G
G
G
V
I
L
D
I
T
V
H
D
A
D
T
L
R
F
V
L
N
--
D
D-
P
I
E
A
V
A
I
S
--
H
S
A
G
MG
K
E
G
L
E
D
G
V
M
G
V
L
R
F
R
S
-
G
V
I
A
Q
F
H
D
A
F
T
T
K
F-----
A
E
T
-
G
L
E
V
H
G
T
A
G
S
L
I
G
R
N
V
-----
M
T
-
Q
RP
V
--
G
-
T
V
V
L
R
-----------
N
E
E
G
----------------
E
S
--
E
L
----
P
L
D
H
R
N
L
Y
E
T
A
I
A
A
F
H
S
A
I
G
G
-
N
G
------
R
P
S
A
S
----
G
E
D
G
V
W
S
L
A
T
G
L
A
V
V
K
A
A
A
T
G
G
A
V
E
I
E
T
G
L
50
HHSearch
47.38
18%
-9
- C1 -
-
3OHS
2
DHDH_MACFA
X:
[2-332]
A
L
R
W
G
I
V
-
S
V
G
L
I
S
S
-
D
F
-
T
A
V
--
L
Q
T
L
P
RS
E
H
Q
V
V
A
V
A
A
R
D
L
S
R
A
K
E
F
A
Q
K
H
--
D
I
-
P
K
A
Y
G
S
Y
E
E
L
A
K
D
P
N
V
E
V
A
Y
V
G
T
Q
H
P
Q
H
K
A
A
V
M
L
C
L
A
A
G
K
A
V
L
C
E
K
P
M
G
V
-
N
A
A
E
V
R
E
M
V
T
E
A
R
S
R
G
L
F
L
-
M
E
A
-
I
W
T
R
F
F
P
A
S
E
A
L
R
S
V
L
A
QG
T
----
L
G
D
L
R
V
A
R
A
E
F
G
K
N
L
T
H
---------
V
P
R
A
V
D
W
A
-
Q
A
G
G
A
L
L
D
L
G
I
Y
C
V
Q
F
I
S
M
V
F
G
--
G
QK
P
E
K
I
S
V
M
G
--
R
R
H
---
E
T
G
V
D
D
T
V
T
V
L
L
Q
Y
P
G
-
E
V
H
G
S
F
T
C
S
I
T
A
Q
------
L
S
N
-
T
A
S
V
S
G
T
K
G
M
A
Q
L
L
N
P
-----
C
W
C
P
-----
T
-
E
L
V
V
K
-----------
G
E
H
K
E
-------
F
-------
L
L
PP
V
P
KN-
C
N
F
D
N
G
A
G
M
S
Y
E
A
K
H
V
R
E
C
L
R
K
-
G
L
----
K
E
S
P
V
I
P
----
L
V
E
S
E
L
L
A
D
I
L
E
E
V
R
R
A
I
G
V
T
F
P
Q
D
-----
51
HHSearch
46.94
18%
-10
- C1 -
-
2POQ
2
DHDH_MACFA
X:
[2-332]
A
L
R
W
G
I
V
-
S
V
G
L
I
S
S
-
D
F
-
T
A
V
--
L
Q
T
L
P
RS
E
H
Q
V
V
A
V
A
A
R
D
L
S
R
A
K
E
F
A
Q
K
H
--
D
I
-
P
K
A
Y
G
S
Y
E
E
L
A
K
D
P
N
V
E
V
A
Y
V
G
T
Q
H
P
Q
H
K
A
A
V
M
L
C
L
A
A
G
K
A
V
L
C
E
K
P
M
G
V
-
N
A
A
E
V
R
E
M
V
T
E
A
R
S
R
G
L
F
L
-
M
E
A
-
I
W
T
R
F
F
P
A
S
E
A
L
R
S
V
L
A
QG
T
----
L
G
D
L
R
V
A
R
A
E
F
G
K
N
L
T
H
---------
V
P
R
A
V
D
W
A
-
Q
A
G
G
A
L
L
D
L
G
I
Y
C
V
Q
F
I
S
M
V
F
G
--
G
QK
P
E
K
I
S
V
M
G
--
R
R
H
---
E
T
G
V
D
D
T
V
T
V
L
L
Q
Y
P
G
-
E
V
H
G
S
F
T
C
S
I
T
A
Q
------
L
S
N
-
T
A
S
V
S
G
T
K
G
M
A
Q
L
L
N
P
-----
C
W
C
P
-----
T
-
E
L
V
V
K
-----------
G
E
H
K
E
-------
F
-------
L
L
PP
V
P
KN-
C
N
F
D
N
G
A
G
M
S
Y
E
A
K
H
V
R
E
C
L
R
K
-
G
L
----
K
E
S
P
V
I
P
----
L
V
E
S
E
L
L
A
D
I
L
E
E
V
R
R
A
I
G
V
T
F
P
Q
D
-----
49
HHSearch
46.34
19%
2
- C1 -
-
1ZH8
6
?
A:
[18-337]
K
I
R
L
G
I
V
-
G
C
G
I
A
A
R
E
L
H
-
L
P
A
--
L
K
N
L
S
H-
L
F
E
I
T
A
V
T
S
R
T
R
S
H
A
E
E
F
A
K
M
V
--
G
N
-
P
A
V
F
D
S
Y
E
E
L
L
E
S
G
L
V
D
A
V
D
L
T
L
P
V
E
L
N
L
P
F
I
E
K
A
L
R
K
G
V
H
V
I
C
E
K
P
I
S
T
-
D
V
E
T
G
K
K
V
V
E
L
S
E
K
S
E
K
T
V
-
Y
I
A
-
E
N
F
R
H
V
P
A
F
W
K
A
K
E
L
V
E
S
G
A
----
I
G
D
P
V
F
M
N
W
Q
I
W
V
G
M
D
E
-
N
N
K
Y
--
V
H
T
D
W
R
K
K
P
K
-
H
V
G
G
F
L
S
D
G
G
V
H
H
A
A
A
M
R
L
I
L
G
--
E
--
I
E
W
I
S
A
V
A
--
K
D
L
SP-
L
L
G
G
M
D
F
L
S
S
I
F
E
F
E
N
-
G
T
V
G
N
Y
T
I
S
Y
S
L
K
------
G
N
E
-
R
F
E
I
T
G
T
K
G
K
I
S
I
S
W
D
-----
K
I
-----------
V
L
N
-----------
E
-
E
E
---------------------
M
---
K
-
V
P
Q
E
N
S
Y
Q
K
E
F
E
D
F
Y
Q
V
V
A
E
-
G
K
P
-----
N
D
L
G
S
----
P
V
Q
A
L
K
D
L
A
F
I
E
A
C
V
R
S
A
G
N
K
V
F
V
S
-----
25
PsiBlast_CBE
45.50
36%
-207
- C1 -
-
3E18
1
?
B:
[66-139]
-------------------------------------------------------------------------
V
D
A
V
L
I
A
T
P
N
D
S
H
K
E
L
A
I
S
A
L
E
A
G
K
H
V
V
C
E
K
P
V
T
M
-
T
S
E
D
L
L
A
I
M
D
V
A
K
R
V
N
K
H
F
-
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
HHSearch
45.27
18%
-19
- C1 -
-
3KUX
-
?
A:
[7-350]
K
I
K
V
G
L
L
-
G
Y
G
Y
A
S
K
T
F
H
-
A
P
L
--
I
M
G
T
P
--
G
L
E
L
A
G
V
S
S
S
D
A
S
K
V
H
--
A
D
W
P
--
A
I
--
P
V
V
S
D
P
Q
M
L
F
N
D
P
S
I
D
L
I
V
I
P
T
P
N
D
T
H
F
P
L
A
Q
S
A
L
A
A
G
K
H
V
V
V
D
K
P
F
T
V
-
T
L
S
Q
A
N
A
L
K
E
H
A
D
D
A
G
L
L
L
-
S
V
F
-
H
N
R
R
W
D
S
D
F
L
T
L
K
T
L
L
A
E
G
S
----
L
G
N
V
V
Y
F
E
S
H
F
D
R
Y
R
P
------
E
-
I
R
Q
R
W
R
E
Q
----
G
G
G
I
W
Y
D
L
G
P
H
L
L
D
Q
A
L
Q
L
F
G
--
L
--
P
E
T
L
N
V
D
L
--
G
M
L
RP-
G
S
Q
S
V
D
Y
F
H
A
V
L
S
Y
P
G
-
Q
-
R
V
V
L
H
S
T
V
L
A
A
A-----
E
T
A
-
R
Y
I
V
H
G
T
Q
G
S
Y
I
K
F
G
V
-----
D
P
-
Q
-----
E
D
R
L
K
A
G
ERLPQADWGYD
M
R
D
G
I
V
T
L
S
H
DN
V
-------
L
T
--
E
K
---
P
L
L
T
L
P
G
N
Y
P
A
Y
Y
A
G
I
R
D
A
I
W
G
-
T
A
------
P
N
P
V
P
----
A
T
E
A
I
K
V
M
E
L
I
E
L
G
I
A
S
D
Q
Q
K
K
A
L
P
I
I
A
--
71
Fugue
44.91
18%
7
- C1 -
-
2O4U
2
DHDH_MACFA
X:
[2-332]
A
L
R
W
G
I
V
-
S
V
G
L
I
S
S
-
D
F
-
T
A
V
LQ
T
L
P
R
S
--
E
H
Q
V
V
A
V
A
A
R
D
L
S
R
A
K
E
F
A
Q
K
H
--
D
I
P
K
A
Y
-
G
S
Y
E
E
L
A
K
D
P
N
V
E
V
A
Y
V
G
T
Q
H
P
Q
H
K
A
A
V
M
L
C
L
A
A
G
K
A
V
L
C
E
K
P
M
G
V
-
N
A
A
E
V
R
E
M
V
T
E
A
R
S
R
G
L
F
L
-
M
E
A
-
I
W
T
R
F
F
P
A
S
E
A
L
R
S
V
L
A
--
Q
GTLG
D
L
R
V
A
R
A
E
F
G
K
N
L
-----------
T
H
V
P
R
A
V
D
W
A
-
Q
A
G
G
A
L
L
D
L
G
I
Y
C
V
Q
F
I
S
M
V
F
G
GQ
K
--
P
E
K
I
S
V
M
G
--
R
R
H
---
E
T
G
V
D
D
T
V
T
V
L
L
Q
Y
P
G
E
V
-
H
G
S
F
T
C
S
I
T
A
Q
------
L
S
N
-
T
A
S
V
S
G
T
K
G
M
A
Q
L
L
N
P
CWCPT
E
L
-
V
-----
V
-
K
G
E
H
K
-----------
E
F
L
L
P
-------
P
-------
V
P
--
K
N
---
C
N
F
D
N
G
A
G
M
S
Y
E
A
K
H
V
R
E
C
L
R
K
-
G
L
K
E
S
P
V
I
P
--------
L
V
E
S
E
L
L
A
D
I
L
E
E
V
R
R
A
I
G
V
T
F
P
Q
D
-----
26
PsiBlast_CBE
43.20
36%
-205
- C1 -
-
3E18
3
?
A:
[66-120]
-------------------------------------------------------------------------
V
D
A
V
L
I
A
T
P
N
D
S
H
K
E
L
A
I
S
A
L
E
A
G
K
H
V
V
C
E
K
P
V
T
M
-
T
S
E
D
L
L
A
I
M
D
V
A
K
R
V
N
K
H
F
-
M
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
HHSearch
42.72
19%
-9
- C1 -
-
4HAD
-
?
C:
[23-350]
M
L
R
F
G
I
I
-
S
T
A
K
I
G
R
D
N
V
-
V
P
A
--
I
Q
D
A
E
--
N
C
V
V
T
A
I
A
S
R
D
L
T
R
A
R
E
M
A
D
R
F
--
S
V
-
P
H
A
F
G
S
Y
E
E
M
L
A
S
D
V
I
D
A
V
Y
I
P
L
P
T
S
Q
H
I
E
W
S
I
K
A
A
D
A
G
K
H
V
V
C
E
K
P
L
A
L
-
K
A
G
D
I
D
A
V
I
A
A
R
D
R
N
K
V
V
V
-
T
E
A
-
Y
M
I
T
Y
S
P
V
W
Q
K
V
R
S
L
I
D
EG
A
----
I
G
S
L
R
H
V
Q
G
A
F
T
Y
F
N
R
D
--------
A
-------------
G
L
P
D
I
G
V
Y
P
V
M
S
T
R
F
S
T
G
--
K
E-
P
L
R
I
Q
A
N
T
--
E
R
D
P--
D
F
G
T
D
I
Y
S
S
V
K
A
D
F
D
D
-
F
-
E
L
S
F
Y
V
S
T
Q
M
A
------
N
R
Q
-
I
M
V
F
H
G
T
N
G
Y
I
E
V
K
S
P
-----
F
N
-
A
NRWGP
E
-
E
I
E
L
A
-----------
D
R
S
H
N
---------------
E
S
--
R
I
---
F
R
F
Q
D
S
R
Q
Y
R
R
E
V
E
A
F
A
R
A
V
E
N
-
G
K
------
E
E
V
V
T
----
L
E
N
S
K
L
N
Q
K
V
I
D
A
I
Y
R
A
S
E
K
D
G
W
E
A
V
----
18
PsiBlast_PDB
42.42
29%
-165
- C1 -
-
3E9M
-
?
A:
[4-126]
-
I
R
Y
G
I
M
-
S
T
A
Q
I
V
P
-
R
F
-
V
A
G
--
L
R
E
S
A
--
Q
A
E
V
R
G
I
A
S
R
R
L
E
N
A
Q
K
M
A
K
E
L
--
A
I
P
V
A
Y
G
S
-
Y
E
E
L
C
K
D
E
T
I
D
I
I
Y
I
P
T
Y
N
Q
G
H
Y
S
A
A
K
L
A
L
S
Q
G
K
P
V
L
L
E
K
P
F
T
L
-
N
A
A
E
A
E
E
L
F
A
I
A
Q
E
Q
G
V
F
L
-
M
E
A
-
Q
K
S
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
HHSearch
42.04
10%
-46
- C1 -
-
5UHW
1
?
A:
[5-344]
E
L
K
G
A
L
I
-
G
C
G
F
F
A
V
-
N
Q
-
M
H
A
--
W
K
D
V
K
--
G
A
G
I
A
A
I
C
D
R
D
P
K
R
L
K
L
V
G
D
Q
F
--
G
I
-
E
R
R
Y
G
D
A
A
A
L
F
A
D
G
G
F
D
F
V
D
I
A
T
T
V
Q
S
H
R
A
L
V
E
M
A
A
A
H
K
V
P
A
I
C
Q
K
P
F
A
K
-
S
L
S
D
A
K
A
M
V
R
T
C
E
N
A
D
I
P
L
-
M
V
H
-
E
N
F
R
W
Q
T
P
I
Q
A
V
K
A
V
L
E
S
G
A
----
I
G
E
P
F
W
G
R
F
S
F
R
S
G
F
D
V
F
---
S
---
G
Q
P
Y
L
A
--
E
-
G
E
R
F
I
I
E
D
L
G
I
H
T
L
D
I
A
R
F
I
L
G
--
D
--
V
A
T
L
T
A
R
T
--
K
R
V
NP-
K
I
K
G
E
D
V
A
T
I
L
L
D
H
Q
N
-
G
A
T
S
I
V
D
V
S
Y
A
T
K
LGTEPF
P
E
T
-
L
I
D
I
D
G
T
Q
G
T
I
R
L
S
Q
G
-----
Y
R
-
L
---------
E
V
T
-----------
G
P
N
G
M
-------
T
I
S
D
A
S
P
Q
L
L
--
S
W
ASR
P
W
H
N
I
Q
E
S
V
L
A
I
Q
Q
H
W
T
D
R
L
S
S
-
G
G
------
E
T
S
T
S
----
G
A
D
N
L
K
T
F
A
L
V
E
A
A
Y
E
S
A
A
N
G
R
T
V
D
I
G
A
M
-
73
Fugue
42.00
18%
13
- C1 -
-
1YDW
-
Y4967_ARATH
B:
[6-360]
Q
I
R
I
G
V
-M
G
C
A
D
I
A
R
-
K
V
-
S
R
A
--
I
H
L
A
P
--
N
A
T
I
S
G
V
A
S
R
S
L
E
K
A
K
A
F
A
T
A
N
NY
P
E
S
T
K
I
H
G
S
Y
E
S
L
L
E
D
P
E
I
D
A
L
Y
V
P
L
P
T
S
L
H
V
E
W
A
I
K
A
A
E
K
G
K
H
I
L
L
E
K
P
-
V
A
M
N
V
T
E
F
D
K
I
V
D
A
C
E
A
N
G
V
Q
I
M
D
G
T
M
W
V
--
H
N
P
R
T
A
L
L
K
E
F
L
S
--
D
----
S
E
R
F
G
Q
L
K
T
V
Q
S
C
F
S
F
A
G
D
E
D
F
L
-
K
N
D
I
R
V
K
P
G
L
-
D
G
L
G
A
L
G
D
A
G
W
Y
A
I
R
A
T
L
L
A
N
N
FE
L
--
P
K
T
V
T
A
F
P
GA
V
L
N
---
E
A
G
V
I
L
S
C
G
A
S
L
S
W
E
D
-
G
-
R
T
A
T
I
Y
C
S
F
L
A
------
N
L
T
M
E
I
T
A
I
G
T
K
G
T
L
R
V
H
D
F
IIP--
Y
K
-
E
-----
T
-
E
A
S
F
T
-----------
T
S
T
K
A
-------
W
-------
F
N
--
D
L
---
V
T
A
W
V
S
P
P
S
E
H
T
V
K
T
E
L
P
Q
E
A
C
M
V
R
E
F
A
I
K
N
N
G
A
K
P
DGYW
P
S
I
S
R
K
T
Q
L
V
V
D
A
V
K
E
S
V
D
K
N
Y
Q
Q
I
S
L
S
--
63
HHSearch
41.63
10%
-48
- C1 -
-
5UI9
2
?
B:
[5-344]
E
L
K
G
A
L
I
-
G
C
G
F
F
A
V
-
N
Q
-
M
H
A
--
W
K
D
V
K
--
G
A
G
I
A
A
I
C
D
R
D
P
K
R
L
K
L
V
G
D
Q
F
--
G
I
-
E
R
R
Y
G
D
A
A
A
L
F
A
D
G
G
F
D
F
V
D
I
A
T
T
V
Q
S
H
R
A
L
V
E
M
A
A
A
H
K
V
P
A
I
C
Q
K
P
F
A
K
-
S
L
S
D
A
K
A
M
V
R
T
C
E
N
A
D
I
P
L
-
M
V
H
-
E
N
F
R
W
Q
T
P
I
Q
A
V
K
A
V
L
E
SG
A
----
I
G
E
P
F
W
G
R
F
S
F
R
S
G
F
D
V
F
---
S
---
G
Q
P
Y
L
A
--
E
-
G
E
R
F
I
I
E
D
L
G
I
H
T
L
D
I
A
R
F
I
L
G
--
D
--
V
A
T
L
T
A
R
T
--
K
R
V
NP-
K
I
K
G
E
D
V
A
T
I
L
L
D
H
Q
N
-
G
A
T
S
I
V
D
V
S
Y
A
T
K
LGTEPF
P
E
T
-
L
I
D
I
D
G
T
Q
G
T
I
R
L
S
Q
G
-----
Y
R
-
L
---------
E
V
T
-----------
G
P
N
G
M
-------
T
ISDASPQ
L
L
--
S
W
ASR
P
W
H
N
I
Q
E
S
V
L
A
I
Q
Q
H
W
T
D
R
L
S
S
-
G
G
------
E
T
S
T
S
----
G
A
D
N
L
K
T
F
A
L
V
E
A
A
Y
E
S
A
A
N
G
R
T
V
D
I
G
A
M
-