@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0135: (2016-03-12 )
MKKFLLVAVISVFALVLTACGGSGASSDKANGSGKAKDGGSLIIGVTGDPEVINPNYASDRVTLTIQQAVYAPLFWEVDGKPALAKSLDISDDNLTYTVKLKDGLTWHDGKPLTADDVVFTVNSILDTKQNSPNRGNFVFDDKPVKVEAVDDTTVKFTLPTVAPAFENTIKTFFPIPKHIFEGVENIEKSDKNKNPIGSGPYKFVEYKTGEYVSLERFNDYFDGKPKLDKVTFRITKDQNAANLALQNGEINLKSIQPSDRNKVEKASAVNIITYPENRLSYATFNENQPALKSKELRQALSYALDREEIIDAAYGSDEYAKPASSFLTENTKYFTDKVETYDQDIAKAKKLVKESGFDTSQKLTVYYLNNSKSQESIALYLQQQYKEIGVTLDLKPTDPNALSNITLDRKNADYSIALNGYIMGNDPDAYKSLYLSDAPYNYSNYHNKDLDALWEKGAVTADDKERQEIYEKIQNTIADDAVIYPISYDNAVLALDSRYGGQKAATPQPVTMFRDLSKLYLTE
Atome Classification :
(20 SA)
.........10........20........30........40......--..50---......--.---.--60...-.-.--...70.--...---.---.-----------.--------.------80--.....---.-..90...-------------.....100.......110----.------.------.......120....----...130.-----------.--------------..---.--.---------------.-------140--------....-----....150----..---.......160-....-.--------..170--.-.-.---.------.-...180..--..----------.-----------..190------.-.-.-..--....200.......210.......220.-----.-.-----....230.......240.......250-..-.--.-..-.--260-...-...-.-..270..-------.....---280...-------------..-------------.-------.290.......300.......310...-....320....-...330....----..---------.-----.-340--..-..-.....350.......360----------.----------.------------.......----370--...----......380.-....-..390....----...400-...--.-----..------..---410...-....420--..--.-.-...430---.-..--.-..-----------.---------.440---.........450.....--..460-........470.......480.......490.......500.......-.510........520..-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MK
K
F
L
L
V
A
V
I
S
V
F
A
L
V
L
T
ACGGSGASSDKANGSGKAKDG
G
S
L
I
I
G
VT--GDPE---VINPNY--A---S--
D
R
V
T
L
-
T
-
I
--
Q
QAVYA--
P
L
F
---
W
---E-----------V--------D------GK--PAL
A
K
---S-LDISDD
N
-------------
L
T
Y
T
V
K
LKDG
L
T
WHDG------K------P------LTAD
D
V
V
F
T
V
N
S
I
L
----DTKQNSP-----------N--------------RG---
N
--
F
---------------
V
-------FD---------DK
P
V
-----
K
V
E
AV------DD---
T
T
V
K
F
TLPTV-
A
P
A
F
-
E
--------
N
T
I
K
---
T
-F-F---P------I-
P
K
H
I
F
E
G
V
--
E
N
----------
I
-----------
E
K
S--------D-K-N-KN--PIGSG
P
Y
K
F
V
E
YKTG
E
Y
V
S
L
E
R
F
N
D
YFD-----G-K-----PKL
D
K
V
T
F
R
I
TKDQNA
A
N
L
A
LQNG
E
I
N
-
L
K
-S--I-QP-S--D---RNK-VEK-A-S
A
V
N
I
I
T-------YPENR---
L
S
Y
A
TF-------------NE-------------N-------QPA
L
K
S
K
E
L
R
Q
A
L
S
Y
AL
D
R
E
E
I
I
D
A
AY-GSDEYAK
P
A
S
S
-
F
LTEN-T
K
Y
F
----
T
D
---------
K
-----
V
-
E
----
T
Y
-
D
Q
-
D
I
A
K
A
K
K
L
V
K
ESGFDT------------S----------
Q
------------
K
L
T
V
Y
Y
L----N----NSK----
S
Q
E
S
I
A
L
Y
L
Q
-
Q
Q
Y
K
-EI
G
V
T
L
D
LK----PTDPN--AL
S
--
N
-----
I
T
------
L
D---RKNA
D
Y
-
S
I
A
L
N
G
Y
--
I
M--G-N-DP
D
A
Y
----
K
-
S
L
--Y-LS-----------D---------AP-----YNYSNYHNK
D
L
D
A
L
W
EK--GAVT--A
D
D
K
E
R
Q
E
I
Y
E
K
I
Q
N
TIADD
A
V
I
Y
P
ISYD
N
A
V
L
A
L
DSRYG-GQKAATP-Q
P
-
V
T
M
F
R
D
L
S
K
L
YLTE-
1
PsiBlast_PDB
94.55
32%
-41
- C2 -
1XOC
15
APPA_BACSU
A:
[17-503]
----------------------------------
K
P
Q
Q
G
G
D
L
V
V
G
S
I
--
G
E
P
T
---
L
F
N
S
L
Y
--
S
---
T
--
D
D
A
S
T
-
D
-
I
--
E
N
M
L
Y
S
--
F
L
T
K
T
D
E
---
K
-----------
L
--------
N
------
V
K
--
L
S
L
A
E
---
S
-
I
K
E
L
D
G
G
-------------
L
A
Y
D
V
K
I
K
K
G
V
K
F
H
D
G
------
K
------
E
------
L
T
A
D
D
V
V
F
T
Y
S
V
P
L
-----
S
K
D
Y
K
G
-----------
E
--------------
R
G
---
S
--
T
---------------
Y
------------------
E
M
L
K
-----
S
V
E
K
K
------
G
D
---
Y
E
V
L
F
K
L
K
Y
K
-
D
G
N
F
Y
N
--------
N
A
L
D
---
S
-
T
-
A
---
I
------
L
-
P
K
H
I
L
G
N
V
PI
A
D
----------
L
-----------
E
E
N
--------
E
-
F
-
N
R
K
K
--
P
I
G
S
G
P
F
K
F
K
E
W
K
Q
G
Q
Y
I
K
L
E
A
N
D
D
Y
F
E
-----
G
-
R
-----
P
Y
L
D
T
V
T
Y
K
V
I
P
D
A
N
A
A
E
A
Q
L
Q
A
G
D
I
N
-
F
F
-
N
--
V
-
P
A
-
T
--
D
---
Y
K
T
-
A
E
K
-
F
-
N
N
L
K
I
V
T
-------
D
L
A
L
S
---
Y
V
Y
I
G
W
-------------
N
E
-------------
K
-------
N
E
L
F
K
D
K
K
V
R
Q
A
L
T
T
A
L
D
R
E
S
I
V
S
Q
V
L
D
G
D
G
E
V
A
Y
I
P
E
S
-
P
L
S
W
N
-
Y
P
K
D
----
I
D
---------------
V
-
P
----
K
F
-
E
Y
-
N
E
K
K
A
K
Q
M
L
A
E
A
G
W
K
D
------------
T
----------
N
GDG
I
L
D
K
DGKKF
S
F
T
L
K
T
N
----
Q
----
G
N
K
----
V
R
E
D
I
A
V
V
V
Q
-
E
Q
L
K
-
K
I
G
I
E
V
K
T
Q
----
I
V
E
W
S
--
A
L
V
--
E
------
Q
------
M
N
---
P
P
N
W
D
F
-
D
A
M
V
M
G
W
--
S
L
--
S
-
T
-
F
P
D
Q
Y
----
D
-
I
F
--
H
-
S
S
-----------
Q
---------
I
K
KG---
L
N
Y
V
W
Y
K
N
A
E
A
D
K
L
M
K
D
--
A
K
S
I
--
S
D
R
K
Q
Y
S
K
E
Y
E
Q
I
Y
Q
K
I
A
E
D
Q
P
Y
T
F
L
Y
Y
P
N
N
H
M
A
M
P
E
N
L
E
-
G
Y
K
-----------------------
22
HHSearch
93.62
31%
-42
- C2 -
1XOC
15
APPA_BACSU
A:
[17-519]
----------------------------------
K
P
Q
Q
G
G
D
L
V
V
G
S
I
--
G
E
P
T
---
L
F
N
S
L
Y
--
S
---
T
--
D
D
A
S
T
-
D
-
I
--
E
N
M
L
Y
S
--
F
L
T
---
K
---
T
-----------
D
--------
E
K-----
L
N
V
K
L
S
L
A
E
---
S
-
I
K
E
L
D
G
G
-------------
L
A
Y
D
V
K
I
K
K
G
V
K
F
H
D
G
------
K
------
E
------
L
T
A
D
D
V
V
F
T
Y
S
V
P
L
----
S
K
D
Y
K
G
E
-----------
R
--------------
G
S
---
T
--
Y
---------------
E
-------
M
L
---------
K
--------
S
V
E
K
K
------
G
D
---
Y
E
V
L
F
K
L
K
Y
K
-
D
G
N
F
-
Y
--------
N
N
A
L
D--
S
-
T
-
A
---
I
------
L
-
P
K
H
I
L
G
N
V
--
P
I
ADLE------
E
-----------
N
E
F
--------
N
-
R
---
K
K
--
P
I
G
S
G
P
F
K
F
K
E
W
K
Q
G
Q
Y
I
K
L
E
A
N
D
D
Y
F
E
-----
G
-
R
-----
P
Y
L
D
T
V
T
Y
K
V
I
P
D
A
N
A
A
E
A
Q
L
Q
A
G
D
I
N
-
F
F
-
N
--
V
-
P
A
-
T
--
D
---
Y
K
T
-
A
E
K
-
F
-
N
N
L
K
I
V
T
-------
D
L
A
L
S
---
Y
V
Y
I
G
W
-------------
N
E
-------------
K
-------
N
E
L
F
K
D
K
K
V
R
Q
A
L
T
T
A
L
D
R
E
S
I
V
S
Q
V
L
-
D
G
D
--
G
E
V
A
Y
I
-
P
E
S
P
L
-
S
W
N
Y
----
P
K
DI-------
D
-----
V
-
P
----
K
F
-
E
Y
-
N
E
K
K
A
K
Q
M
L
A
E
A
G
W
K
D
TNGDG
I
L
D
K
DGK
K
----------
F
------------
S
F
T
L
K
T
N
----
Q
----
G
N
K
----
V
R
E
D
I
A
V
V
V
Q
-
E
Q
L
K
-
K
I
G
I
E
V
K
T
Q
----
I
V
E
W
S
--
A
L
V
--
E
-----
Q
M
-------
N
P--
P
N
-
W
D
F
-
D
A
M
V
M
G
W
--
S
L
--
S
-
T
-
F
P
D
Q
-----
Y
-
D
I
--
F
-
H
S
SQI--------
K
---------
K
G
-----
L
N
Y
V
W
Y
K
N
A
E
A
D
K
L
M
K
D
--
A
K
S
I
--
S
D
R
K
Q
Y
S
K
E
Y
E
Q
I
Y
Q
K
I
A
E
D
Q
P
Y
T
F
L
Y
Y
P
N
N
H
M
A
M
P
E
N
L
E
-
G
Y
K
---
Y
-
H
P
-
K
R
D
L
Y
N
I
E
K
W
W
L
A
--
21
HHSearch
88.56
25%
-49
- C2 -
1UQW
12
GSIB_ECOLI
A:
[23-508]
-------------------------------------
A
A
K
D
V
V
V
A
V
G
--
S
N
F
T
---
T
L
D
P
Y
D
--
A
---
N
--
D
T
L
S
Q
-
A
-
V
--
A
K
S
F
Y
Q
--
G
L
F
---
G
---
L
-----------
D
--------
K
E-----
M
K
L
K
N
V
L
A
E
---
S
-
Y
T
V
S
D
D
G
-------------
I
T
Y
T
V
K
L
R
E
G
I
K
F
Q
D
G
------
T
------
D
------
F
N
A
A
A
V
K
A
N
L
D
R
A
S
----
D
P
A
N
H
L
K
-----------
R
--------------
H
N
---
L
--
Y
---------------
K
-------
N
I
---------
A
--------
K
T
E
A
I
------
D
P
---
T
T
V
K
I
T
L
K
Q
P
-
F
S
A
F
-
I
--------
N
I
L
A
HP-
A
-
T
-
A
---
M
------
I
-
S
P
A
A
L
E
K
Y
--
G
-----------------------
K
E
I
--------
G
-----
F
Y
--
P
V
G
T
G
P
Y
E
L
D
T
W
N
Q
T
D
F
V
K
V
K
K
F
A
G
Y
W
Q
-----
P
G
L
-----
P
K
L
D
S
I
T
W
R
P
V
A
D
N
N
T
R
A
A
M
L
Q
T
G
E
A
Q
-
F
A
-
F
P-
I
-
P
Y
-
E
--
Q
---
A
T
L
-
L
E
K
-
N
-
K
N
I
E
L
M
A
-------
S
P
S
I
M
---
Q
R
Y
I
S
M
-------------
N
V
-------------
T
-------
Q
K
P
F
D
N
P
K
V
R
E
A
L
N
Y
A
I
N
R
P
A
L
V
K
V
A
F
-
A
G
Y
--
A
T
P
A
T
G
-
V
V
P
P
S
-
I
A
Y
A
-----
Q
---------
S
-----
Y
-
K
----
P
W
-
P
Y
-
D
P
V
K
A
R
E
L
L
K
E
A
G
Y
P
N
------------
G
----------
F
------------
S
T
T
L
W
S
S
----
H
----
N
H
S
----
T
A
Q
K
V
L
Q
F
T
Q
-
Q
Q
L
A
-
Q
V
G
I
K
A
Q
V
T
----
A
M
D
A
G
--
Q
R
A
--
A
-----
E
V
------
E
G
KGQ
K
E
-
S
G
V
-
R
M
F
Y
T
G
W
--
S
A
--
S
T
G
-
E
A
D
W
A
----
L
S
P
L
--
F
-
A
S
-----------
Q
NWPP-----
T
L
-----
F
N
T
A
F
Y
S
N
K
Q
V
D
D
F
L
A
Q
--
A
L
K
T
--
N
D
P
A
E
K
T
R
L
Y
K
A
A
Q
D
I
I
W
Q
E
S
P
W
I
P
L
V
V
E
K
L
V
S
A
H
S
K
N
L
T
-
G
F
W
---
I
-
M
P
-
D
T
G
F
-
S
F
E
D
A
D
L
---
27
HHSearch
86.38
23%
-39
- C2 -
1JET
6
OPPA_SALTY
A:
[9-516]
-----------------------------------
L
A
D
K
Q
T
L
V
R
N
N
G
--
S
E
V
Q
---
S
L
D
P
H
K
--
I
---
E
--
G
V
P
E
S
-
N
-
V
--
S
R
D
L
F
E
--
G
L
L
---
I
---
S
-----------
D
--------
V
E-----
G
H
PS
P
G
V
A
E
---
K
-
W
E
N
-
K
D
F
-------------
K
V
W
T
F
H
L
R
E
N
A
K
W
S
D
G
------
T
------
P
------
V
T
A
H
D
F
V
Y
S
W
Q
R
L
A
----
D
P
N
T
A
S
P
-----------
Y
--------------
A
S
---
Y
L
Q
Y
G
HIAN
I
D
D
I
I
A
GKKP
A
-------
T
D
---------
L
--------
G
V
K
A
L
------
D
D
---
H
T
F
E
V
T
L
S
E
P
-
V
P
Y
F
-
Y
--------
K
L
L
V
HP-
S
-
V
-
S
---
P
------
V
-
P
K
S
A
V
E
K
F
--
G
D
-----------------------
K
W
--------
T
-
Q
-
P
-
A
N
--
I
V
T
N
G
A
Y
K
L
K
N
W
V
V
N
E
R
I
V
L
E
R
N
P
Q
Y
W
D
-----
N
A
K
-----
T
V
I
N
Q
V
T
Y
L
P
I
S
S
E
V
T
D
V
N
R
Y
R
S
G
E
I
D
-
M
T
-
Y
NN
M
-
P
I
-
E
--
L
---
F
Q
K
-
L
K
K
-
E
-
I
P
N
E
V
R
V
-------
D
P
Y
L
C
---
T
Y
Y
Y
E
I
-------------
N
N
-------------
Q
-------
K
A
P
F
N
D
V
R
V
R
T
A
L
K
L
A
L
D
R
D
I
I
V
N
K
V
K
-
N
Q
G
--
D
L
P
A
Y
S
-
Y
T
P
P
Y
-
T
D
G
A
----
K
L
---------
V
-----
E
P
E
WFKW
S
Q
-
Q
K
-
R
N
E
E
A
K
K
L
L
A
E
A
G
F
T
A
------------
D
K
P
--------
L
------------
T
F
D
L
L
Y
N
----
T
----
S
-
D
----
L
H
K
K
L
A
I
A
V
A
-
S
I
W
K
K
N
L
G
V
N
V
N
L
E
----
N
Q
E
W
K
--
T
F
L
--
D
-----
T
R
-------
H
----
Q
-
G
T
F
-
D
V
A
R
A
G
W
--
C
A
--
D
Y
N
-
E
P
T
S
F
----
L
-
N
T
--
M
-
L
S
-----------
D
---------
S
S
-----
N
N
T
A
H
Y
K
S
P
A
F
D
K
L
I
A
D
--
T
L
K
V
--
A
D
D
T
Q
R
S
E
L
Y
A
K
A
E
Q
Q
L
D
K
D
S
A
I
V
P
V
Y
Y
Y
V
N
A
R
L
V
K
P
W
V
G
-
G
Y
T
---
G
K
D
P
-
L
D
N
I
-
Y
V
K
N
L
Y
I
I
K
-
2
PsiBlast_PDB
85.79
26%
-45
- C2 -
1UQW
12
GSIB_ECOLI
A:
[23-485]
----------------------------------
A
A
K
D
---
V
V
V
A
V
G
--
S
N
F
T
---
T
L
D
P
Y
D
--
A
---
N
--
D
T
L
S
Q
-
A
-
V
--
A
K
S
F
Y
Q
--
G
L
F
---
G
L
D
K
E
-----------
M
--------
K
------
L
K
--
N
V
L
A
E
---
S
-
Y
T
V
S
D
D
G
-------------
I
T
Y
T
V
K
L
R
E
G
I
K
F
Q
D
G
------
T
------
D
------
F
N
A
A
A
V
K
A
N
L
D
R
A
S
----
D
P
A
-
N
H
L
-----------
K
--------------
R
H
---
N
--
L
---------------
Y
------------------
K
N
I
A
-----
K
T
E
A
I
------
D
P
---
T
T
V
K
I
T
L
K
Q
P
-
F
S
A
F
-
I
--------
N
I
L
A
---
H
----------------
P
A
T
A
M
I
S
P
--
A
A
----------
L
-----------
E
K
Y
--------
G
-
K
-
E
-
I
G
FY
P
V
G
T
G
P
Y
E
L
D
T
W
N
Q
T
D
F
V
K
V
K
K
F
A
G
Y
W
Q
P----
G
-
L
-----
P
K
L
D
S
I
T
W
R
P
V
A
D
N
N
T
R
A
A
M
L
Q
T
G
E
A
Q
-
F
A
-
F
--
P
-
I
P
-
Y
--
E
---
Q
A
T
L
L
E
K
-
N
-
K
N
I
E
L
M
A
-------
S
P
S
I
M
---
Q
R
Y
I
S
M
-------------
N
V
-------------
T
-------
Q
K
P
F
D
N
P
K
V
R
E
A
L
N
Y
A
I
N
R
P
A
L
V
K
V
A
F
-
A
G
--
Y
A
T
P
A
T
G
-
V
V
P
P
S
-
I
A
Y
-----
A
Q
---------
S
-----
Y
-
K
----
P
W
-
P
Y
-
D
P
V
K
A
R
E
L
L
K
E
A
G
Y
P
N
------------
G
----------
F
------------
S
T
T
L
W
S
S
----
H
----
N
H
S
----
T
A
Q
K
V
L
Q
F
T
Q
-
Q
Q
L
A
-
Q
V
G
I
K
A
Q
V
T
----
A
M
D
A
G
Q
R
A
A
E
--
V
-----
E
G
------
K
G
---
Q
K
E
S
G
V
-
R
M
F
Y
T
G
W
S
A
S
T
--
G
-
E
-
A
D
W
A
L
----
S
-
P
L
--
F
-
A
S
Q----------
N
---------
W
P
PTL--
F
N
T
A
F
Y
S
N
K
Q
V
D
D
F
L
A
Q
--
A
L
K
T
--
N
D
P
A
E
K
T
R
L
Y
K
A
A
Q
D
I
I
W
Q
E
S
P
W
I
P
L
V
V
E
K
L
V
S
A
---------------------------------
23
HHSearch
85.75
24%
-45
- C2 -
3TPA
-
?
A:
[8-513]
---------------------------------------
N
T
L
V
N
C
I
A
--
T
A
P
M
---
K
L
S
P
A
I
--
T
---
N
--
D
A
N
D
F
-
N
A
S
--
S
Q
Q
V
Y
N
--
R
L
V
---
E
---
F
-----------
K
--------
A
GK----
I
E
VE
P
G
L
A
E
---
R
-
W
E
I
S
E
D
G
-------------
L
V
Y
T
F
Y
L
R
Q
N
V
K
F
H
S
N
KTFSPT
R
------
P
------
L
N
A
D
D
V
V
F
S
F
Q
R
Q
A
----
D
K
N
H
P
Y
H
NVSAGTY
F
Y
F
N
W
--------------
M
N
---
L
--
P
---------------
S
-------
I
L
---------
K
--------
S
V
E
K
V
------
D
D
---
Y
T
V
K
I
T
L
N
K
P
-
N
T
P
F
-
I
--------
T
T
V
A
MD-
F
-
L
-
S
---
I
------
Y
-
S
K
E
Y
A
D
Q
L
--
L
A
----------
Q
-----------
G
K
P
--------
E
-
T
-
L
D
Q
Q
--
P
I
G
T
G
P
F
I
F
Q
T
N
Q
T
D
H
A
V
R
Y
T
A
N
V
D
Y
W
K
-----
G
-
K
-----
A
D
I
E
R
L
I
F
S
I
T
P
D
A
G
T
R
Y
A
K
L
K
A
G
E
C
D
-
V
I
-
D
F-
P
-
N
I
-
S
--
D
---
I
A
Q
-
M
K
K
-
D
-
P
Q
I
N
L
L
E
-------
R
E
G
L
N
---
L
A
Y
I
G
L
-------------
N
T
-------------
T
-------
K
P
E
L
N
N
V
K
V
R
Q
A
L
H
H
A
T
D
K
K
A
I
V
D
A
V
Y
-
Q
G
G
--
G
T
V
A
T
N
-
P
F
P
D
A
-
V
L
G
Y
----
N
P
---------
H
-----
L
-
P
----
Q
Y
-
E
F
-
N
L
E
K
A
K
A
L
L
A
E
A
G
Y
P
N
------------
G
----------
F
------------
E
T
E
I
W
V
Q
PVVR
P
----
S
N
P
----
N
P
R
R
T
A
E
I
I
Q
-
A
D
W
A
-
K
I
G
V
K
A
K
L
V
----
T
H
E
W
A
--
D
F
N
--
K
-----
R
T
-------
R
----
E
-
G
E
F
-
A
A
G
T
Y
G
W
--
T
S
--
R
N
G
-
D
P
D
N
F
----
L
F
P
L
--
F
-
S
Q
-----------
A
NI-------
P
G
-----
T
N
Y
S
R
W
T
D
E
K
F
E
A
L
L
A
S
--
A
A
Q
I
--
Q
D
T
Q
T
R
A
K
L
Y
Q
Q
A
V
E
I
F
Q
Q
N
S
P
I
I
P
F
A
H
S
I
N
Y
V
P
L
N
K
R
V
Q
-
G
F
V
---
Q
-
N
P
-
F
G
Y
T
-
A
F
Y
G
V
S
L
K
--
25
HHSearch
85.67
25%
-45
* C2 *
1DPE
5
DPPA_ECOLI
A:
[1-507]
---------------------------------------
K
T
L
V
Y
C
S
E
--
G
S
P
E
---
G
F
N
P
Q
L
--
F
---
I
--
S
G
T
T
Y
D
A
-
S
--
S
V
P
L
Y
N
--
R
L
V
---
E
---
F
-----------
K
--------
I
GT----
T
E
V
I
P
G
L
A
E
---
K
-
W
E
V
S
E
D
G
-------------
K
T
Y
T
F
H
L
R
K
G
V
K
W
H
D
N
------
K
EFKPTR
E
------
L
N
A
D
D
V
V
F
S
F
D
R
Q
K
----
N
A
Q
N
P
Y
H
KVSGGSY
E
Y
--
F
E
G
------------
M
G
---
L
--
P
---------------
E
-------
L
I
---------
S
--------
E
V
K
K
V
------
D
D
---
N
T
V
Q
F
V
L
T
R
P
-
E
A
P
F
-
L
--------
A
D
L
A
MD-
F
-
A
-
S
---
I
------
L
-
S
K
E
Y
A
D
A
M
--
M
K
----------
A
GTP--------
E
K
L
--------
D
-----
L
N
--
P
I
G
T
G
P
F
Q
L
Q
Q
Y
Q
K
D
S
R
I
R
Y
K
A
F
D
G
Y
W
G
-----
T
-
K
-----
P
Q
I
D
T
L
V
F
S
I
T
P
D
A
S
V
R
Y
A
K
L
Q
K
N
E
C
Q
-
V
M
-
P
Y-
P
-
N
P
-
A
--
D
---
I
A
R
-
M
K
Q
-
D
-
K
S
I
N
L
M
E
-------
M
P
G
L
N
---
V
G
Y
L
S
Y
-------------
N
V
-------------
Q
-------
K
K
P
L
D
D
V
K
V
R
Q
A
L
T
Y
A
V
N
K
D
A
I
I
K
A
V
Y
-
Q
G
A
--
G
V
S
A
K
N
-
L
I
P
P
T
-
M
W
G
Y
----
N
D
---------
D
-----
V
-
Q
----
D
Y
-
T
Y
-
D
P
E
K
A
K
A
L
L
K
E
A
G
L
E
K
------------
G
----------
F
------------
S
I
D
L
W
A
M
----
P
VQRP
Y
N
P
----
N
A
R
R
M
A
E
M
I
Q
-
A
D
W
A
-
K
V
G
V
Q
A
K
I
V
----
T
Y
E
W
G
--
E
Y
L
--
K
-----
R
A
-------
K
----
D
-
G
E
H
-
Q
T
V
M
M
G
W
--
T
G
--
D
N
G
-
D
P
D
N
F
----
F
A
T
E
--
F
-
S
C
A
A
S
--------
E
---------
Q
G
-----
S
N
Y
S
K
W
C
Y
K
P
F
E
D
L
I
Q
P
--
A
R
A
T
--
D
D
H
N
K
R
V
E
L
Y
K
Q
A
Q
V
V
M
H
D
Q
A
P
A
L
I
I
A
H
S
T
V
F
E
P
V
R
K
E
V
K
-
G
Y
V
---
V
-
D
P
-
L
G
K
H
-
H
F
E
N
V
S
I
E
--
6
PsiBlast_PDB
82.44
27%
-36
- C2 -
4ZE8
7
?
A:
[6-456]
----------------------------------------
A
L
R
L
G
V
N
--
G
L
P
N
---
S
L
E
P
V
N
--
A
---
I
--
S
N
V
G
P
-
R
-
I
--
V
N
Q
I
F
D
--
T
L
I
---
A
---
R
DFFAKGAPGNA
I
--------
D
------
L
V
--
P
A
L
A
E
---
S
-
W
E
R
I
D
E
K
--------------
S
V
R
F
K
L
R
Q
K
V
M
F
H
D
G
------
V
------
E
------
L
T
A
D
D
V
A
Y
T
F
S
S
E
R
LWGP
E
A
I
K
K
I
P
-----------
L
--------------
G
K
---
S
--
Y
---------------
S
-------
L
D
F--------
D
E
P
V
------
V
E
--------
D
K
---
Y
T
V
--
T
L
R
T
K
-
T
P
S
Y
-----------
L
I
E
---
T
-
F
-
V
---
A
SWM
S
R
I
V
-
P
K
E
Y
Y
K
K
L
--
G
A
----------
V
-----------
D
F
G
--------
N
-
K
-------
P
V
G
T
G
P
Y
K
F
V
E
F
V
A
G
D
R
V
V
L
E
A
N
D
A
Y
W
G
-----
P
-
K
-----
P
T
A
S
K
I
T
Y
Q
I
V
A
E
P
A
T
R
V
A
G
L
I
S
G
E
Y
D
I
I
T
-
T
--
L
-
T
P
-
D
--
D
---
I
Q
L
-
I
N
S
-
Y
-
P
D
L
E
T
R
G
-------
T
L
I
E
N
---
F
H
M
F
T
F
-------------
N
M
-------------
N
-------
Q
E
V
F
K
D
K
K
L
R
R
A
L
A
L
A
V
N
R
P
I
M
V
E
A
L
W
--
K
K
Q
A
S
I
P
A
G
F
-
N
F
P
N
Y
-
G
E
T
F
----
D
P
---------
K
-----
R
-
K
----
A
M
-
E
Y
-
N
V
E
E
A
K
R
L
V
K
E
S
G
Y
D
G
------------
T
-----------------------
P
I
T
Y
H
T
M
----
G
----
N
Y
Y
----
A
N
A
M
P
A
L
M
M
M
I
E
M
W
K
-
Q
I
G
V
N
V
V
M
K
----
T
Y
A
P
G
--
S
F
P
PD
N
-----
Q
T
------
W
M
---
R
N
W
S
-------
N
G
Q
--
W
M
--
T
-----
D
A
Y
----
A
-
T
I
--
V
-
P
E
-----------
F
---------
G
P
NGQVQ
K
R
W
G
W
K
A
P
A
E
F
N
E
L
C
Q
K
--
V
T
V
L
--
P
N
G
K
E
R
F
D
A
Y
N
R
M
R
D
I
F
E
E
E
A
----------------------------------------------
35
HHSearch
81.93
18%
-36
- C2 -
2D5W
1
?
A:
[4-569]
-------------------------------------
Q
D
N
S
L
V
I
G
A
S
--
Q
E
P
R
---
V
L
A
G
D
F
LR
V
---
I
SN
Q
A
I
K
S
-
E
-
I
--
E
Q
Y
L
F
A
--
P
F
I
---
G
---
F
-----------
N
--------
A
D-----
S
Q
N
F
P
V
L
A
T
---
E
-
V
P
T
L
E
N
G
R
L
R
V
T
D
IGGG
K
K
R
L
E
M
D
I
T
I
R
P
D
A
K
W
S
D
G
------
R
------
P
------
I
T
T
E
D
V
A
F
Y
F
E
V
G
K
----
A
K
G
M
P
V
L
--------------------------
N
P
---
D
--
F
---------------
W
-------
E
R
---------
V
--------
N
V
R
I
K
------
D
A
---
R
N
F
T
L
I
F
E
P
A
-
Y
Y
Y
D
----------
T
Y
G
P
---
I
-
N
-
T
---
Y
------
A
-
P
K
H
I
M
G
P
E
--
W
E
R
V
K
A
A
A
R
G
LD
P
DKD
A
E
K
L
N
E
L
Y
R
N
F
F
L
K
F
A
T
P
Q
A
-
L
-
N
R
G
A
--
M
V
Y
S
G
P
F
K
L
K
R
W
V
P
G
N
S
I
E
M
E
R
N
P
N
F
P
I
KPEGG
E
-
S
-----
K
Y
V
Q
K
V
V
Y
R
F
I
Q
N
T
N
S
L
L
V
A
V
I
G
G
S
I
D
-
A
T
-
S
S-
V
-
S
L
-
T
F
D
Q
G
R
S
P
Q
L
-
V
R
R
A
P
-
G
R
F
D
I
W
F
-------
V
P
G
A
I
---
W
E
H
I
D
I
-------------
N
K
-------------
F
ENC
Q
V
V
K
D
L
G
L
N
D
K
R
T
R
Q
A
I
L
H
A
L
N
R
E
G
L
V
K
A
F
F
-
D
G
L
--
Q
P
V
A
H
T
-
W
I
A
P
V
-
N
P
L
F
----
N
P
---------
N
-----
V
-
K
----
K
Y
-
E
F
-
D
L
K
K
A
E
A
L
L
A
E
M
G
W
R
K
G
PDG
I
L
Q
R
T
V
N-
G
R
T
--------
V
------------
R
F
E
I
E
Y
V
T
T--
A
----
G
N
V
----
V
R
E
R
T
Q
Q
F
F
A
-
E
D
L
K
-
K
I
G
I
A
V
K
I
N
----
N
A
P
S
A
--
V
V
F
--
A
DEFIQ
R
A
-------
S
----
E
-
C
K
W
T
G
M
F
E
F
A
W
--
V
S
--
N
L
Q
-
E
D
G
S
L
----
F
-
Q
Y
KN
L
-
N
T
GAIMVPTKENN
Y
---------
Q
G
-----
Q
N
I
G
G
W
R
N
D
E
F
D
R
L
T
S
Q
--
A
V
L
E
--
F
D
P
E
R
R
K
Q
L
F
W
R
A
Q
E
I
W
A
E
E
L
P
A
L
P
L
Y
F
R
A
N
P
Y
V
V
R
K
G
L
V
-
N
Y
V
---
A
-
S
A
-
Y
S
-------------
7
PsiBlast_PDB
81.92
27%
-35
- C2 -
4ZEB
2
?
A:
[6-456]
----------------------------------------
A
L
R
L
G
V
N
--
G
L
P
N
---
S
L
E
P
V
N
--
A
---
I
--
S
N
V
G
P
-
R
-
I
--
V
N
Q
I
F
D
--
T
L
I
---
A
---
R
DFFAKGAPGNA
I
--------
D
------
L
V
--
P
A
L
A
E
---
S
-
W
E
R
I
D
E
K
--------------
S
V
R
F
K
L
R
Q
K
V
M
F
H
D
G
------
V
------
E
------
L
T
A
D
D
V
A
Y
T
F
S
S
E
R
LWGP
E
A
I
K
K
I
P
-----------
L
--------------
G
K
---
S
--
Y
---------------
S
-------
L
D
F--------
D
E
P
V
------
V
E
--------
D
K
---
Y
T
V
--
T
L
R
T
K
-
T
P
S
Y
-----------
L
I
E
---
T
-
F
-
V
---
A
SWM
S
R
I
V
-
P
K
E
Y
Y
K
K
L
--
G
A
----------
V
-----------
D
F
G
--------
N
-
K
-------
P
V
G
T
G
P
Y
K
F
V
E
F
V
A
G
D
R
V
V
L
E
A
N
D
A
Y
W
G
-----
P
-
K
-----
P
T
A
S
K
I
T
Y
Q
I
V
A
E
P
A
T
R
V
A
G
L
I
S
G
E
Y
D
I
I
T
-
T
--
L
-
T
P
-
D
--
D
---
I
Q
L
-
I
N
S
-
Y
-
P
D
L
E
T
R
G
-------
T
L
I
E
N
---
F
H
M
F
T
F
-------------
N
M
-------------
N
-------
Q
E
V
F
K
D
K
K
L
R
R
A
L
A
L
A
V
N
R
P
I
M
V
E
A
L
W
--
K
K
Q
A
S
I
P
A
G
F
-
N
F
P
N
Y
-
G
E
T
F
----
D
P
---------
K
-----
R
-
K
----
A
M
-
E
Y
-
N
V
E
E
A
K
R
L
V
K
E
S
G
Y
D
G
------------
T
-----------------------
P
I
T
Y
H
T
M
----
G
----
N
Y
Y
----
A
N
A
M
P
A
L
M
M
M
I
E
M
W
K
-
Q
I
G
V
N
V
V
M
K
----
T
Y
A
P
G
--
S
F
P
PD
N
-----
Q
T
------
W
M
---
R
N
W
S
-------
N
G
Q
--
W
M
--
T
-----
D
A
Y
----
A
-
T
I
--
V
-
P
E
-----------
F
---------
G
P
NGQVQ
K
R
W
G
W
K
A
P
A
E
F
N
E
L
C
Q
K
--
V
T
V
L
--
P
N
G
K
E
R
F
D
A
Y
N
R
M
R
D
I
F
E
E
E
A
----------------------------------------------
36
HHSearch
81.84
21%
-45
- C2 -
2O7I
1
?
A:
[7-525]
-------------------------------------
R
E
D
T
V
Y
I
G
G
A
LW
G
P
A
T
---
T
W
N
L
Y
A
--
P
---
Q
--
S
--
T
W
-
G
-
T
--
D
Q
F
M
Y
L
--
P
A
F
---
Q
---
Y
-----------
D
--------
L
GR----
D
A
WI
P
V
I
A
E
---
R
-
Y
E
F
V
-
D
D
-------------
K
T
L
R
I
Y
I
R
P
E
A
R
W
S
D
G
------
V
------
P
------
I
T
A
D
D
F
V
Y
A
L
E
L
T
K
----
E
L
G
I
G
P
------------
G
--------------
G
G
---
W
--
D
---------------
T
-------
Y
I
---------
E
--------
Y
V
K
A
V
------
D
T
---
K
V
V
E
F
K
A
K
E
E
-
N
L
N
Y
-
F
--------
Q
F
L
S
Y
S
L
G
-
A
-
Q
---
P
------
M
-
P
K
H
V
Y
E
R
I
--
R
A
Q
MN-------
I
-----------
K
D
W
--------
I
N
D
-
K
P
E
E
--
Q
V
V
S
G
P
Y
K
L
Y
Y
Y
D
P
N
-
I
V
V
Y
Q
R
V
D
D
W
W
G
-----
K
-
D
IFGL-
P
R
P
K
Y
L
A
H
V
I
Y
K
D
N
P
S
A
S
L
A
F
E
R
G
D
I
D
-
W
N
-
G
L-
F
-
I
P
-
S
--
V
---
W
E
L
-
W
E
K
---
K
G
L
P
V
G
T
WYKKEPY
F
I
P
D
G
---
V
G
F
V
Y
V
-------------
N
N
-------------
T
-------
K
P
G
L
S
D
P
A
V
R
K
A
I
A
Y
A
I
P
Y
N
E
M
L
K
K
A
Y
-
F
G
Y
--
G
S
Q
A
H
P
S
M
V
I
D
L
-
F
E
P
Y
KQYI
D
Y
E
L
A
K
K
T
FGT
E
-----
D
-
G
----
R
I
-
P
F
-
D
L
D
M
A
N
K
I
L
D
E
A
G
Y
K
K
------------
G
PDG
V
R
V
G
PDG
T
KLG---------
P
Y
T
I
S
V
P
----
Y
----
G
W
T
----
D
W
M
M
M
C
E
M
I
A
-
K
N
L
R
-
S
I
G
I
D
V
K
T
E
----
F
P
D
F
S
--
V
W
A
--
D
-----
R
M
-------
T
----
K
-
G
T
F
-
D
L
I
I
-
S
W
--
S
V
G
P
S
F
D
-
H
P
F
N
I
----
Y
-
R
F
--
V
L
D
K
-----------
R
LSKPVGEVT
W
A
-----
G
D
W
E
R
Y
D
N
D
E
V
V
E
L
L
D
K
--
A
V
S
T
--
L
D
P
E
V
R
K
Q
A
Y
F
R
I
Q
Q
I
I
Y
R
D
M
P
S
I
P
A
F
Y
T
A
H
W
Y
E
Y
S
T
K
Y
W
I
N
W
P
-----------------------
53
Fugue
81.82
19%
-49
- C2 -
3DRJ
1
?
A:
[14-573]
--------------------
L
K
A
G
N
F
D
V
A
Y
Q
N
P
D
K
A
I
K
G
G
N
L
K
V
A
Y
Q
--
S
D
S
P
M
K
A
Q
W
L
S
G
L
--
S
---
N
--
D
A
T
F
A
-
T
-
M
--
S
G
P
G
G
G
QD
G
L
F
---
F
---
T
-----------
D
--------
S
------
G
F
--
K
F
I
K
G
GA
A
D
-
V
A
L
D
K
E
S
-------------
K
T
A
T
I
T
L
R
K
D
L
K
W
S
D
G
------
S
------
E
------
V
T
A
K
D
Y
E
F
T
Y
E
T
I
A
----
N
P
A
Y
G
S
D
-----------
R
--------------
W
T
---
D
--
S
---------------
L
-------
A
N
IVG
L
S
D
Y
H
T
G
K
A
K
-----
T
I
S
G
I
TFPDGE
N
G
---
K
V
I
K
V
Q
F
K
E
M
-
K
P
G
M
-
T
--------
Q
S
G
N
---
G
-
Y
-
F
LET
V
------
A
-
P
Y
Q
Y
L
K
D
V
AP
K
D
----------
L
-----------
A
S
S
--------
P
-
K
T
T
-
T
K
--
P
L
V
T
G
P
F
K
P
E
N
V
V
A
G
E
S
I
K
Y
V
P
N
P
Y
Y
W
G
-----
E
-
K
-----
P
K
L
N
S
I
T
Y
E
V
V
-
S
T
A
K
S
V
A
A
L
S
S
S
K
Y
D
-
I
I
N
G
--
M
-
V
S
-
S
--
Q
---
Y
K
Q
-
V
K
N
-
L
-
K
G
Y
K
V
L
G
-------
Q
Q
A
M
Y
---
I
S
L
M
Y
Y
N
L
G
HYDAKNSINV
Q
D
-------------
R
-------
K
T
P
L
Q
D
Q
N
V
R
Q
A
I
G
Y
A
R
N
V
A
E
V
D
N
K
F
S
-
N
G
--
L
S
T
P
A
N
S
-
L
I
P
P
I
F
K
Q
F
T
----
S
S
---------
S
-----
V
-
K
----
G
Y
-
E
K
Q
D
L
D
K
A
N
K
L
L
D
E
D
G
W
K
L
------------
N
----------
K
STG
Y
R
E
K
DGKEL
S
L
V
Y
A
A
R
----
V
----
G
D
A
----
N
A
E
T
I
A
Q
N
Y
I
-
Q
Q
W
K
-
K
I
G
V
K
V
S
L
Y
NG
K
L
M
E
F
N
S
--
W
V
D
--
H
-----
M
T
------
T
P
---
P
G
A
N
D
W
-
D
I
T
D
G
S
W
--
S
L
--
A
-
S
-
E
P
S
Q
-----
Q
-
D
L
--
F
-
S
A
-----------
A
---------
A
P
-----
Y
N
F
G
H
F
N
D
S
E
I
T
K
D
L
N
D
I
D
S
A
K
S
--
E
N
P
T
Y
R
K
A
A
F
V
K
Y
Q
E
D
M
N
K
K
A
Y
V
I
P
T
N
F
M
L
N
Y
T
P
V
N
K
R
V
V
-
G
M
T
L
D
Y
G
-
A
M
-----
N
T
W
S
E
I
G
V
S
S
A
5
PsiBlast_PDB
81.71
27%
-36
- C2 -
4RA1
6
?
A:
[6-456]
----------------------------------------
A
L
R
L
G
V
N
--
G
L
P
N
---
S
L
E
P
V
N
--
A
---
I
--
S
N
V
G
P
-
R
-
I
--
V
N
Q
I
F
D
--
T
L
I
---
A
---
R
DFFAKGAPGNA
I
--------
D
------
L
V
--
P
A
L
A
E
---
S
-
W
E
R
I
D
E
K
--------------
S
V
R
F
K
L
R
Q
K
V
M
F
H
D
G
------
V
------
E
------
L
T
A
D
D
V
A
Y
T
F
S
S
E
R
LWGP
E
A
I
K
K
I
P
-----------
L
--------------
G
K
---
S
--
Y
---------------
S
-------
L
D
F--------
D
E
P
V
------
V
E
--------
D
K
---
Y
T
V
--
T
L
R
T
K
-
T
P
S
Y
-----------
L
I
E
---
T
-
F
-
V
---
A
SWMSRI
V
-
P
K
E
Y
Y
K
K
L
--
G
A
----------
V
-----------
D
F
G
--------
N
-
K
-------
P
V
G
T
G
P
Y
K
F
V
E
F
V
A
G
D
R
V
V
L
E
A
N
D
A
Y
W
G
-----
P
-
K
-----
P
T
A
S
K
I
T
Y
Q
I
V
A
E
P
A
T
R
V
A
G
L
I
S
G
E
Y
D
I
I
T
-
T
--
L
-
T
P
-
D
--
D
---
I
Q
L
-
I
N
S
-
Y
-
P
D
L
E
T
R
G
-------
T
L
I
E
N
---
F
H
M
F
T
F
-------------
N
M
-------------
N
-------
Q
E
V
F
K
D
K
K
L
R
R
A
L
A
L
A
V
N
R
P
I
M
V
E
A
L
W
--
K
K
Q
A
S
I
P
A
G
F
-
N
F
P
N
Y
-
G
E
T
F
----
D
P
---------
K
-----
R
-
K
----
A
M
-
E
Y
-
N
V
E
E
A
K
R
L
V
K
E
S
G
Y
D
G
------------
T
-----------------------
P
I
T
Y
H
T
M
----
G
----
N
Y
Y
----
A
N
A
M
P
A
L
M
M
M
I
E
M
W
K
-
Q
I
G
V
N
V
V
M
K
----
T
Y
A
P
G
--
S
F
P
PD
N
-----
Q
T
------
W
M
---
R
N
W
S
-------
N
G
Q
--
W
M
--
T
-----
D
A
Y
----
A
-
T
I
--
V
-
P
E
-----------
F
---------
G
P
NGQVQ
K
R
W
G
W
K
A
P
A
E
F
N
E
L
C
Q
K
--
V
T
V
L
--
P
N
G
K
E
R
F
D
A
Y
N
R
M
R
D
I
F
E
E
E
A
----------------------------------------------
9
PsiBlast_PDB
81.64
27%
-36
- C2 -
4ZED
2
?
A:
[6-456]
----------------------------------------
A
L
R
L
G
V
N
--
G
L
P
N
---
S
L
E
P
V
N
--
A
---
I
--
S
N
V
G
P
-
R
-
I
--
V
N
Q
I
F
D
--
T
L
I
---
A
---
R
DFFAKGAPGNA
I
--------
D
------
L
V
--
P
A
L
A
E
---
S
-
W
E
R
I
D
E
K
--------------
S
V
R
F
K
L
R
Q
K
V
M
F
H
D
G
------
V
------
E
------
L
T
A
D
D
V
A
Y
T
F
S
S
E
R
LWGP
E
A
I
K
K
I
P
-----------
L
--------------
G
K
---
S
--
Y
---------------
S
-------
L
D
F--------
D
E
P
V
------
V
E
--------
D
K
---
Y
T
V
--
T
L
R
T
K
-
T
P
S
Y
-----------
L
I
E
---
T
-
F
-
V
---
A
SWMSRI
V
-
P
K
E
Y
Y
K
K
L
--
G
A
----------
V
-----------
D
F
G
--------
N
-
K
-------
P
V
G
T
G
P
Y
K
F
V
E
F
V
A
G
D
R
V
V
L
E
A
N
D
A
Y
W
G
-----
P
-
K
-----
P
T
A
S
K
I
T
Y
Q
I
V
A
E
P
A
T
R
V
A
G
L
I
S
G
E
Y
D
I
I
T
-
T
--
L
-
T
P
-
D
--
D
---
I
Q
L
-
I
N
S
-
Y
-
P
D
L
E
T
R
G
-------
T
L
I
E
N
---
F
H
M
F
T
F
-------------
N
M
-------------
N
-------
Q
E
V
F
K
D
K
K
L
R
R
A
L
A
L
A
V
N
R
P
I
M
V
E
A
L
W
--
K
K
Q
A
S
I
P
A
G
F
-
N
F
P
N
Y
-
G
E
T
F
----
D
P
---------
K
-----
R
-
K
----
A
M
-
E
Y
-
N
V
E
E
A
K
R
L
V
K
E
S
G
Y
D
G
------------
T
-----------------------
P
I
T
Y
H
T
M
----
G
----
N
Y
Y
----
A
N
A
M
P
A
L
M
M
M
I
E
M
W
K
-
Q
I
G
V
N
V
V
M
K
----
T
Y
A
P
G
--
S
F
P
PD
N
-----
Q
T
------
W
M
---
R
N
W
S
-------
N
G
Q
--
W
M
--
T
-----
D
A
Y
----
A
-
T
I
--
V
-
P
E
-----------
F
---------
G
P
NGQVQ
K
R
W
G
W
K
A
P
A
E
F
N
E
L
C
Q
K
--
V
T
V
L
--
P
N
G
K
E
R
F
D
A
Y
N
R
M
R
D
I
F
E
E
E
A
----------------------------------------------
8
PsiBlast_PDB
81.36
27%
-34
- C2 -
4ZEC
4
?
A:
[6-456]
----------------------------------------
A
L
R
L
G
V
N
--
G
L
P
N
---
S
L
E
P
V
N
--
A
---
I
--
S
N
V
G
P
-
R
-
I
--
V
N
Q
I
F
D
--
T
L
I
---
A
---
R
DFFAKGAPGNA
I
--------
D
------
L
V
--
P
A
L
A
E
---
S
-
W
E
R
I
D
E
K
--------------
S
V
R
F
K
L
R
Q
K
V
M
F
H
D
G
------
V
------
E
------
L
T
A
D
D
V
A
Y
T
F
S
S
E
R
LWGP
E
A
I
K
K
I
P
-----------
L
--------------
G
K
---
S
--
Y
---------------
S
-------
L
D
F--------
D
E
P
V
------
V
E
--------
D
K
---
Y
T
V
--
T
L
R
T
K
-
T
P
S
Y
-----------
L
I
E
---
T
-
F
-
V
---
A
SWMSRI
V
-
P
K
E
Y
Y
K
K
L
--
G
A
----------
V
-----------
D
F
G
--------
N
-
K
-------
P
V
G
T
G
P
Y
K
F
V
E
F
V
A
G
D
R
V
V
L
E
A
N
D
A
Y
W
G
-----
P
-
K
-----
P
T
A
S
K
I
T
Y
Q
I
V
A
E
P
A
T
R
V
A
G
L
I
S
G
E
Y
D
I
I
T
-
T
--
L
-
T
P
-
D
--
D
---
I
Q
L
-
I
N
S
-
Y
-
P
D
L
E
T
R
G
-------
T
L
I
E
N
---
F
H
M
F
T
F
-------------
N
M
-------------
N
-------
Q
E
V
F
K
D
K
K
L
R
R
A
L
A
L
A
V
N
R
P
I
M
V
E
A
L
W
--
K
K
Q
A
S
I
P
A
G
F
-
N
F
P
N
Y
-
G
E
T
F
----
D
P
---------
K
-----
R
-
K
----
A
M
-
E
Y
-
N
V
E
E
A
K
R
L
V
K
E
S
G
Y
D
G
------------
T
-----------------------
P
I
T
Y
H
T
M
----
G
----
N
Y
Y
----
A
N
A
M
P
A
L
M
M
M
I
E
M
W
K
-
Q
I
G
V
N
V
V
M
K
----
T
Y
A
P
G
--
S
F
P
PD
N
-----
Q
T
------
W
M
---
R
N
W
S
-------
N
G
Q
--
W
M
--
T
-----
D
A
Y
----
A
-
T
I
--
V
-
P
E
-----------
F
---------
G
P
NGQVQ
K
R
W
G
W
K
A
P
A
E
F
N
E
L
C
Q
K
--
V
T
V
L
--
P
N
G
K
E
R
F
D
A
Y
N
R
M
R
D
I
F
E
E
E
A
----------------------------------------------
33
HHSearch
81.27
18%
-41
- C2 -
2WOL
3
?
A:
[28-560]
----------------------------------
S
R
R
R
G
G
T
L
R
L
V
S
S
--
A
D
V
D
---
S
L
D
P
A
R
--
T
---
Y
--
Y
V
W
V
W
-
L
-
L
--
Q
R
L
L
N
R
--
T
L
M
---
A
---
Y
-----------
P
--------
T
DPGPAG
L
V
PA
P
D
L
A
E
---
G
P
G
E
V
S
D
G
G
-------------
R
T
W
T
Y
R
L
R
R
G
L
R
Y
D
D
G
------
T
------
P
------
I
T
S
D
D
V
R
H
A
V
Q
R
V
F
----
A
Q
D
V
L
P
G
G----------
P
T
Y
L
I
P
L
L
DDPERPY
P
G
PYR
T
--
D
---------------
E
-------
P
L
---------
R
--------
S
V
L
T
P
------
D
E
---
H
T
I
V
F
R
L
T
R
P
-
F
S
D
F
-
D
--------
H
L
M
A
QP-
C
-
A
-
A
---
P
------
V
-
P
R
R
S
D
T
G
A
---------------------------
D
Y
--------
G
-----
R
D
--
P
R
S
S
G
P
Y
R
V
A
R
H
E
P
D
T
L
L
H
L
E
R
N
P
H
W
D
R
-----
A
-
T
DPIRP
A
L
P
D
R
V
E
L
T
I
G
L
D
V
D
V
L
D
A
R
L
I
A
G
E
F
D
-
I
N
-
L
E-
G
-
R
G
L
Q
--
H
---
A
A
Q
-
R
R
A
-
T
A
D
E
V
L
R
S
H
-------
T
D
N
P
R
TS
F
L
H
F
V
A
M
-------------
Q
P
-------------
H
-------
I
P
P
F
D
N
V
H
V
R
R
A
V
Q
Y
A
A
D
K
I
L
L
Q
D
A
R
G
-
G
P
V
N
G
G
D
L
T
T
A
-
L
F
P
P
T
-
L
P
A
H
----
Q
D
---------
L
DLYPT
G
-
P
----
D
L
-
R
G
-
D
L
D
A
A
R
A
E
L
A
A
A
G
L
P
D
------------
G
----------
F
------------
R
A
V
I
G
T
Q
----------
R
G
----
K
F
R
L
V
A
D
A
V
V
-
E
S
L
A
-
R
V
G
I
E
L
T
V
K
----
E
L
D
V
A
--
T
Y
F
--
S
-----
L
G
AGH
P
E
T
V
R
----
E
-
H
G
L
-
G
L
L
V
T
D
W
--
G
A
--
D
F
P
-
T
E
Y
G
F
----
L
A
P
L
--
V
-
D
G
RQIKRN-----
G
---------
G
N
-----
W
N
L
P
E
L
D
D
P
E
V
N
A
L
I
D
E
--
T
L
H
T
--
T
D
P
A
A
R
A
E
L
W
R
A
V
E
R
R
V
M
E
H
A
V
L
L
P
L
V
H
D
K
T
L
H
F
R
N
P
W
V
T
-
N
V
Y
---
V
-
H
P
A
F
G
L
Y
-
D
I
Q
A
M
G
L
A
E
-
11
PsiBlast_PDB
81.25
27%
-33
- C2 -
4ZEK
6
?
A:
[6-456]
----------------------------------------
A
L
R
L
G
V
N
--
G
L
P
N
---
S
L
E
P
V
N
--
A
---
I
--
S
N
V
G
P
-
R
-
I
--
V
N
Q
I
F
D
--
T
L
I
---
A
---
R
DFFAKGAPGNA
I
--------
D
------
L
V
--
P
A
L
A
E
---
S
-
W
E
R
I
D
E
K
--------------
S
V
R
F
K
L
R
Q
K
V
M
F
H
D
G
------
V
------
E
------
L
T
A
D
D
V
A
Y
T
F
S
S
E
R
LWGP
E
A
I
K
K
I
P
-----------
L
--------------
G
K
---
S
--
Y
---------------
S
-------
L
D
F--------
D
E
P
V
------
V
E
--------
D
K
---
Y
T
V
--
T
L
R
T
K
-
T
P
S
Y
-----------
L
I
E
---
T
-
F
-
V
---
A
SWMSRI
V
-
P
K
E
Y
Y
K
K
L
--
G
A
----------
V
-----------
D
F
G
--------
N
-
K
-------
P
V
G
T
G
P
Y
K
F
V
E
F
V
A
G
D
R
V
V
L
E
A
N
D
A
Y
W
G
-----
P
-
K
-----
P
T
A
S
K
I
T
Y
Q
I
V
A
E
P
A
T
R
V
A
G
L
I
S
G
E
Y
D
I
I
T
-
T
--
L
-
T
P
-
D
--
D
---
I
Q
L
-
I
N
S
-
Y
-
P
D
L
E
T
R
G
-------
T
L
I
E
N
---
F
H
M
F
T
F
-------------
N
M
-------------
N
-------
Q
E
V
F
K
D
K
K
L
R
R
A
L
A
L
A
V
N
R
P
I
M
V
E
A
L
W
--
K
K
Q
A
S
I
P
A
G
F
-
N
F
P
N
Y
-
G
E
T
F
----
D
P
---------
K
-----
R
-
K
----
A
M
-
E
Y
-
N
V
E
E
A
K
R
L
V
K
E
S
G
Y
D
G
------------
T
-----------------------
P
I
T
Y
H
T
M
----
G
----
N
Y
Y
----
A
N
A
M
P
A
L
M
M
M
I
E
M
W
K
-
Q
I
G
V
N
V
V
M
K
----
T
Y
A
P
G
--
S
F
P
PD
N
-----
Q
T
------
W
M
---
R
N
W
S
-------
N
G
Q
--
W
M
--
T
-----
D
A
Y
----
A
-
T
I
--
V
-
P
E
-----------
F
---------
G
P
NGQVQ
K
R
W
G
W
K
A
P
A
E
F
N
E
L
C
Q
K
--
V
T
V
L
--
P
N
G
K
E
R
F
D
A
Y
N
R
M
R
D
I
F
E
E
E
A
----------------------------------------------
32
HHSearch
81.06
22%
-45
- C2 -
3DRF
1
?
A:
[32-570]
--------------------------------------
G
G
N
L
K
V
A
Y
Q
--
S
D
S
P
---
M
K
A
Q
W
L
--
S
GLS
N
--
D
A
T
F
A
-
T
-
M
S
G
P
G
G
G
Q
D
--
G
L
F
---
F
---
T
-----------
D
--------
S
G-----
F
K
FI
K
G
G
A
A
---
D
-
V
A
L
D
K
E
S
-------------
K
T
A
T
I
T
L
R
K
D
L
K
W
S
D
G
------
S
------
E
------
V
T
A
K
D
Y
E
F
T
Y
E
T
I
A
----
N
P
A
Y
G
S
D
R----------
W
TDSLANIVG
L
S
D
Y
H
T
G
---
K
--
A
---------------
K
-------
T
I
---------
S
--------
G
I
T
F
P
------
D
G
ENG
K
V
I
K
V
Q
F
K
E
M
-
K
P
G
M
-
T
QSGNGYFL
E
T
V
A
PY-
Q
Y
L
K
D
---
V
------
A
-
P
K
D
L
A
S
S
P
---------------------------
K
T
--------
T
-----
T
K
--
P
L
V
T
G
P
F
K
P
E
N
V
V
A
G
E
S
I
K
Y
V
P
N
P
Y
Y
W
G
-----
E
-
K
-----
P
K
L
N
S
I
T
Y
E
V
V
S
T
A
-
K
S
V
A
A
L
S
S
S
K
Y
D
-
I
I
-
N
G-
M
-
V
S
-
S
--
Q
---
Y
K
Q
-
V
K
N
-
L
-
K
G
Y
K
V
L
G
-------
Q
Q
A
M
Y
---
I
S
L
M
Y
Y
-------------
N
L
GHYDAKNSINVQ
D
R
-------
K
T
P
L
Q
D
Q
N
V
R
Q
A
I
G
Y
A
R
N
V
A
E
V
D
N
K
F
S
-
N
G
L
--
S
T
P
A
N
S
-
L
I
P
P
I
-
F
K
Q
F
----
T
S
S--------
S
-----
V
-
K
----
G
Y
E
K
Q
-
D
L
D
K
A
N
K
L
L
D
E
D
G
W
K
L
NKSTG
Y
R
E
K
D--
G
----------
K
------------
E
L
S
L
V
Y
A
A
R
--
V
----
G
D
A
----
N
A
E
T
I
A
Q
N
Y
I
-
Q
Q
W
K
-
K
I
G
V
K
V
S
L
Y
NG
K
-
L
M
E
F
N
--
S
W
V
--
D
-----
H
M
------
T
T
PP-
G
A
-
N
D
W
-
D
I
T
D
G
S
W
--
S
L
--
A
-
S
-
E
P
S
Q
-----
Q
-
D
L
--
F
-
S
A
-----------
A
---------
A
P
-----
Y
N
F
G
H
F
N
D
S
E
I
T
K
D
L
N
D
--
I
D
S
A
KS
E
N
P
T
Y
R
K
A
A
F
V
K
Y
Q
E
D
M
N
K
K
A
Y
V
I
P
T
N
F
M
L
N
Y
T
P
V
N
K
R
V
V
-
G
M
T
---
L
-
D
Y
-
G
A
M
N
-
T
W
S
E
I
G
V
---
3
PsiBlast_PDB
81.06
25%
-44
- C2 -
1DPE
5
DPPA_ECOLI
A:
[2-470]
----------------------------------------
T
L
V
Y
C
S
E
--
G
S
P
E
---
G
F
N
P
Q
L
--
F
--------
I
S
G
-
T
-
T
--
Y
D
A
S
S
V
--
P
L
Y
---
N
---
R
-----------
L
VEFKIGTT
E
------
V
I
--
P
G
L
A
E
---
K
-
W
E
V
S
E
D
G
-------------
K
T
Y
T
F
H
L
R
K
G
V
K
W
H
D
N
------
K
------
E
FKPTRE
L
N
A
D
D
V
V
F
S
----
F
----
D
R
Q
K
N
A
Q
-----------
N
--------------
P
Y
---
H
--
K
---------------
V
SGGSY
E
Y
F
E
---------
G
M
G
L
P
E
L
I
S
E
V
K
K
V
------
D
D
---
N
T
V
Q
F
V
L
T
R
P
E
A
P
F
L
-
A
--------
D
L
A
M
---
D
-
F
-
A
---
S
------
I
L
S
K
E
Y
A
D
A
M
--
M
K
----------
A
-----------
G
T
P
--------
E
-
K
L
D
-
L
N
--
P
I
G
T
G
P
F
Q
L
Q
Q
Y
Q
K
D
S
R
I
R
Y
K
A
F
D
G
Y
W
G
-----
T
-
K
-----
P
Q
I
D
T
L
V
F
S
I
T
P
D
A
S
V
R
Y
A
K
L
Q
K
N
E
C
Q
-
V
M
-
P
--
Y
P
N
P
-
A
--
D
---
I
A
R
-
M
K
Q
-
D
-
K
S
I
N
L
M
E
-------
M
P
G
L
N
---
V
G
Y
L
S
Y
-------------
N
V
-------------
Q
-------
K
K
P
L
D
D
V
K
V
R
Q
A
L
T
Y
A
V
N
K
D
A
I
I
K
A
V
Y
-
Q
G
A
G
V
S
--
A
K
N
-
L
I
P
P
T
-
M
W
G
Y
----
N
D
---------
D
-----
V
-
Q
----
D
Y
-
T
Y
-
D
P
E
K
A
K
A
L
L
K
E
A
G
L
E
K
------------
G
----------
F
------------
S
I
D
L
W
A
M
----
P
----
V
Q
R
PYNP
N
A
R
R
M
A
E
M
I
Q
-
A
D
W
A
-
K
V
G
V
Q
A
K
I
V
----
T
Y
E
-----
W
G
--
E
-----
Y
L
------
K
R
---
A
K
D
G
E
H
-
Q
T
V
M
M
G
W
--
T
G
--
D
-
N
G
D
P
D
N
F
FATE
F
-
S
C
--
A
-
A
S
-----------
E
---------
Q
G
-----
S
N
Y
S
K
W
C
Y
K
P
F
E
D
L
I
Q
P
--
A
R
A
T
--
D
D
H
N
K
R
V
E
L
Y
K
Q
A
Q
V
V
M
H
D
Q
A
----------------------------------------------
4
PsiBlast_PDB
80.95
25%
-38
- C2 -
1DPP
1
DPPA_ECOLI
A:
[2-470]
----------------------------------------
T
L
V
Y
C
S
E
--
G
S
P
E
---
G
F
N
P
Q
L
--
F
---
T
--
S
G
T
T
Y
-------
D
A
S
S
V
--
P
L
Y
---
N
---
R
-----------
L
VEFKIGTT
E
------
V
I
--
P
G
L
A
E
---
K
-
W
E
V
S
E
D
G
-------------
K
T
Y
T
F
H
L
R
K
G
V
K
W
H
D
N
------
K
------
E
FKPTRE
L
N
A
D
D
V
V
F
S
----
F
----
D
R
Q
K
N
A
Q
-----------
N
--------------
P
Y
---
H
--
K
---------------
V
SGGSY
E
Y
F
E
---------
G
M
G
L
P
E
L
I
S
E
V
K
K
V
------
D
D
---
N
T
V
Q
F
V
L
T
R
P
E
A
P
F
L
-
A
--------
D
L
A
M
---
D
-
F
-
A
---
S
------
I
L
S
K
E
Y
A
D
A
M
--
M
K
----------
A
-----------
G
T
P
--------
E
-
K
L
D
-
L
N
--
P
I
G
T
G
P
F
Q
L
Q
Q
Y
Q
K
D
S
R
I
R
Y
K
A
F
D
G
Y
W
G
-----
T
-
K
-----
P
Q
I
D
T
L
V
F
S
I
T
P
D
A
S
V
R
Y
A
K
L
Q
K
N
E
C
Q
-
V
M
-
P
--
Y
P
N
P
-
A
--
D
---
I
A
R
-
M
K
Q
-
D
-
K
S
I
N
L
M
E
-------
M
P
G
L
N
---
V
G
Y
L
S
Y
-------------
N
V
-------------
Q
-------
K
K
P
L
D
D
V
K
V
R
Q
A
L
T
Y
A
V
N
K
D
A
I
I
K
A
V
Y
-
Q
G
A
G
V
S
--
A
K
N
-
L
I
P
P
T
-
M
W
G
Y
----
N
D
---------
D
-----
V
-
Q
----
D
Y
-
T
Y
-
D
P
E
K
A
K
A
L
L
K
E
A
G
L
E
K
------------
G
----------
F
------------
S
I
D
L
W
A
M
----
P
----
V
Q
R
PYNP
N
A
R
R
M
A
E
M
I
Q
-
A
D
W
A
-
K
V
G
V
Q
A
K
I
V
----
T
Y
E
-----
W
G
--
E
-----
Y
L
------
K
R
---
A
K
D
G
E
H
-
Q
T
V
M
M
G
W
--
T
G
--
D
-
N
G
D
P
D
N
F
----
F
-
A
T
--
L
-
F
S
-----------
C
---------
A
A
S
E
QG-
S
N
Y
S
K
W
C
Y
K
P
F
E
D
L
I
Q
P
--
A
R
A
T
--
D
D
H
N
K
R
V
E
L
Y
K
Q
A
Q
V
V
M
H
D
Q
A
----------------------------------------------