@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0343: (2016-03-14 )
MKFFLDTASVSEIKRISELGLVDGVTTNPTIIAKEGRPFEEVIKEICSIVDGPVSAEVIGLEADKMVEEARILAKWAPNVVVKIPMTEEGLKAVHTLTAEGIKTNVTLIFTVSQGLMAAKAGATYISPFLGRLDDIGTDGMILIKNLKKVLDNYGLKAEIISASIRHIGHLEEAAEAGAHIATIPGSLFPKLWSHPLTDKGIEGFLKDWEAFSQKEGN
Atome Classification :
(50 SA)
.........10-----........20........30....---------..--------------------.-----.40-------------------.----------------------.----..---------------------------------..----.--------..---------50........---.60--.........70......--.-------..-------80........90.......-.100.......110.......120..-----------------.....130...--------------.---------.--------------.----------.--140.......150..------------..-...160..--.....170.---......180-.......190.......200.......210......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
K
F
F
LDTA
S
V
S
-----
E
I
K
R
I
S
ELGLVDGVTTN
P
T
I
I
AKE---------GR--------------------
P
-----
F
E
--------------------
E
----------------------
V
----
I
K
---------------------------------
E
I
----
C
--------
S
I---------V-DGPVS
A
E
V
---
I
G---L
E
A
D
K
M
V
E
E
A
-
R
I
L
A
KW--A-------P
N
-------
V
V
V
K
I
PM
T
E
E
G
L
K
A
V
H
T
L
T
-AEGIKT
N
V
T
L
I
F
TVSQ
G
L
M
A
AKAG
A
T
-----------------
Y
I
S
P
F
L
G
R
L
D
D--------------I---------G--------------T----------D--
G
M
I
L
I
K
N
L
K
K
V
L
D
NY------------GL-
K
A
E
I
I
S
A
S
--
I
R
HI
G
H
L
E
E
---
A
A
EAGA
H
I
A
-TI
P
G
S
L
F
P
K
L
WSHPLT
D
K
G
I
E
G
F
L
K
D
W
E
A
F
SQKEGN
87
HHSearch
94.68
58%
-115
- C3 -
3R8R
2
TAL_BACSU
A:
[1-212]
M
L
F
F
V
D
T
A
N
I
D
-----
E
I
R
E
A
N
E
L
G
I
L
A
G
V
T
T
N
P
S
L
V
A
K
E
---------
A
N
V-------------------
S
-----
F
H
--------------------
D
----------------------
R
----
L
R
---------------------------------
E
I
----
T
--------
D
V
---------
V
-
K
G
S
V
S
A
E
V
---
I
S
---
L
K
A
E
E
M
I
E
E
G
-
K
E
L
A
K
I
--
A
-------
P
N
-------
I
T
V
K
I
P
M
T
S
D
G
L
K
A
V
R
A
L
T
-
D
L
G
I
K
T
N
V
T
L
I
F
N
A
N
Q
A
L
L
A
A
R
A
G
A
T
-----------------
Y
V
S
P
F
L
G
R
L
D
D
--------------
I
---------
G
--------------
H
----------
N
--
G
L
D
L
I
S
E
V
K
Q
I
F
D
I
H
------------
G
L
-
D
T
Q
I
I
A
A
S
--
I
R
H
P
Q
H
V
T
E
---
A
A
L
R
G
A
H
I
G
-
T
M
P
L
K
V
I
H
A
L
T
K
H
P
L
T
D
K
G
I
E
Q
F
L
A
D
W
N
K
-------
56
PsiBlast_CBE
94.54
58%
-117
- C3 -
3R8R
2
TAL_BACSU
B:
[1-210]
M
L
F
F
V
D
T
A
N
I
D
-----
E
I
R
E
A
N
E
L
G
I
L
A
G
V
T
T
N
P
S
L
V
A
K
E
---------
A
N
V
-------------------
S
-----
F
H
--------------------
D
----------------------
R
----
L
R
---------------------------------
E
I
----
T
--------
D
V
---------
V
-
K
G
S
V
S
A
E
V
---
I
S
---
L
K
A
E
E
M
I
E
E
G
-
K
E
L
A
K
I
--
A
-------
P
N
-------
I
T
V
K
I
P
M
T
S
D
G
L
K
A
V
R
A
L
T
-
D
L
G
I
K
T
N
V
T
L
I
F
N
A
N
Q
A
L
L
A
A
R
A
G
A
T
-----------------
Y
V
S
P
F
L
G
R
L
D
D
--------------
I
---------
G
--------------
H
----------
N
--
G
L
D
L
I
S
E
V
K
Q
I
F
D
I
H
------------
G
L
-
D
T
Q
I
I
A
A
S
--
I
R
H
P
Q
H
V
T
E
---
A
A
L
R
G
A
H
I
G
-
T
M
P
L
K
V
I
H
A
L
T
K
H
P
L
T
D
K
G
I
E
Q
F
L
A
D
W
---------
54
PsiBlast_CBE
94.40
58%
-121
- C3 -
3R8R
1
TAL_BACSU
D:
[1-210]
M
L
F
F
V
D
T
A
N
I
D
-----
E
I
R
E
A
N
E
L
G
I
L
A
G
V
T
T
N
P
S
L
V
A
---------------------------------
S
-----
F
H
--------------------
D
----------------------
R
----
L
R
---------------------------------
E
I
----
T
--------
D
V
---------
V
-
K
G
S
V
S
A
E
V
---
I
S
---
L
K
A
E
E
M
I
E
E
G
-
K
E
L
A
K
I
--
A
-------
P
N
-------
I
T
V
K
I
P
M
T
S
D
G
L
K
A
V
R
A
L
T
-
D
L
G
I
K
T
N
V
T
L
I
F
N
A
N
Q
A
L
L
A
A
R
A
G
A
T
-----------------
Y
V
S
P
F
L
G
R
L
D
D
--------------
I
---------
G
--------------
H
----------
N
--
G
L
D
L
I
S
E
V
K
Q
I
F
D
I
H
------------
G
L
-
D
T
Q
I
I
A
A
S
--
I
R
H
P
Q
H
V
T
E
---
A
A
L
R
G
A
H
I
G
-
T
M
P
L
K
V
I
H
A
L
T
K
H
P
L
T
D
K
G
I
E
Q
F
L
A
D
W
---------
2
PsiBlast_PDB
94.38
58%
-115
- C3 -
3R8R
2
TAL_BACSU
A:
[1-210]
M
L
F
F
V
D
T
A
N
I
D
-----
E
I
R
E
A
N
E
L
G
I
L
A
G
V
T
T
N
P
S
L
V
A
K
E
---------
A
N
V-------------------
S
-----
F
H
--------------------
D
----------------------
R
----
L
R
---------------------------------
E
I
----
T
--------
D
V
---------
V
-
K
G
S
V
S
A
E
V
---
I
S
---
L
K
A
E
E
M
I
E
E
G
-
K
E
L
A
K
I
--
A
-------
P
N
-------
I
T
V
K
I
P
M
T
S
D
G
L
K
A
V
R
A
L
T
-
D
L
G
I
K
T
N
V
T
L
I
F
N
A
N
Q
A
L
L
A
A
R
A
G
A
T
-----------------
Y
V
S
P
F
L
G
R
L
D
D
--------------
I
---------
G
--------------
H
----------
N
--
G
L
D
L
I
S
E
V
K
Q
I
F
D
I
H
------------
G
L
-
D
T
Q
I
I
A
A
S
--
I
R
H
P
Q
H
V
T
E
---
A
A
L
R
G
A
H
I
G
-
T
M
P
L
K
V
I
H
A
L
T
K
H
P
L
T
D
K
G
I
E
Q
F
L
A
D
W
---------
40
PsiBlast_CBE
93.71
58%
-115
- C3 -
3R8R
24
TAL_BACSU
W:
[1-210]
M
L
F
F
V
D
T
A
N
I
D
-----
E
I
R
E
A
N
E
L
G
I
L
A
G
V
T
T
N
P
S
L
V
A
K
E
---------
A
N
V-------------------
S
-----
F
H
--------------------
D
----------------------
R
----
L
R
---------------------------------
E
I
----
T
--------
D
V
---------
V
-
K
G
S
V
S
A
E
V
---
I
S
---
L
K
A
E
E
M
I
E
E
G
-
K
E
L
A
K
I
--
A
-------
P
N
-------
I
T
V
K
I
P
M
T
S
D
G
L
K
A
V
R
A
L
T
-
D
L
G
I
K
T
N
V
T
L
I
F
N
A
N
Q
A
L
L
A
A
R
A
G
A
T
-----------------
Y
V
S
P
F
L
G
R
L
D
D
--------------
I
---------
G
--------------
H
----------
N
--
G
L
D
L
I
S
E
V
K
Q
I
F
D
I
H
------------
G
L
-
D
T
Q
I
I
A
A
S
--
I
R
H
P
Q
H
V
T
E
---
A
A
L
R
G
A
H
I
G
-
T
M
P
L
K
V
I
H
A
L
T
K
H
P
L
T
D
K
G
I
E
Q
F
L
A
D
W
---------
30
PsiBlast_CBE
93.54
56%
-117
- C3 -
1VPX
1
TAL_THEMA
K:
[13-224]
M
K
I
F
L
D
T
A
N
L
E
-----
E
I
K
K
G
V
E
W
G
I
V
D
G
V
T
T
N
P
T
L
I
S
K
E
---------
G
A
--------------------
E
-----
F
K
--------------------
Q
----------------------
R
----
V
K
---------------------------------
E
I
----
C
--------
D
L
---------
V
-
K
G
P
V
S
A
E
V
---
V
S
---
L
D
Y
E
G
M
V
R
E
A
-
R
E
L
A
Q
I
--
S
-------
E
Y
-------
V
V
I
K
I
P
M
T
P
D
G
I
K
A
V
K
T
L
S
-
A
E
G
I
K
T
N
V
T
L
V
F
S
P
A
Q
A
I
L
A
A
K
A
G
A
T
-----------------
Y
V
S
P
F
V
G
R
M
D
D
--------------
L
---------
S
--------------
N
----------
D
--
G
M
R
M
L
G
E
I
V
E
I
Y
N
N
Y
------------
G
F
-
E
T
E
I
I
A
A
S
--
I
R
H
P
M
H
V
V
E
---
A
A
L
M
G
V
D
I
V
-
T
M
P
F
A
V
L
E
K
L
F
K
H
P
M
T
D
L
G
I
E
R
F
M
E
D
W
K
K
Y
------
38
PsiBlast_CBE
92.64
56%
-115
- C3 -
1VPX
1
TAL_THEMA
C:
[13-219]
M
K
I
F
L
D
T
A
N
L
E
-----
E
I
K
K
G
V
E
W
G
I
V
D
G
V
T
T
N
P
T
L
I
S
K
E
---------
G
A
--------------------
E
-----
F
K
--------------------
Q
----------------------
R
----
V
K
---------------------------------
E
I
----
C
--------
D
L
---------
V
-
K
G
P
V
S
A
E
V
---
V
S
---
L
D
Y
E
G
M
V
R
E
A
-
R
E
L
A
Q
I
--
S
-------
E
Y
-------
V
V
I
K
I
P
M
T
P
D
G
I
K
A
V
K
T
L
S
-
A
E
G
I
K
T
N
V
T
L
V
F
S
P
A
Q
A
I
L
A
A
K
A
G
A
T
-----------------
Y
V
S
P
F
V
G
R
M
D
D
--------------
L
---------
S
--------------
N
----------
D
--
G
M
R
M
L
G
E
I
V
E
I
Y
N
N
Y
------------
G
F
-
E
T
E
I
I
A
A
S
--
I
R
H
P
M
H
V
V
E
---
A
A
L
M
G
V
D
I
V
-
T
M
P
F
A
V
L
E
K
L
F
K
H
P
M
T
D
L
G
I
E
R
F
M
E
-----------
26
PsiBlast_CBE
92.38
56%
-118
- C3 -
1VPX
1
TAL_THEMA
O:
[13-220]
M
K
I
F
L
D
T
A
N
L
E
-----
E
I
K
K
G
V
E
W
G
I
V
D
G
V
T
T
N
P
T
L
I
S
K
E
---------
G
A
--------------------
E
-----
F
K
--------------------
Q
----------------------
R
----
V
K
---------------------------------
E
I
----
C
--------
D
L
---------
V
-
K
G
P
V
S
A
E
V
---
V
S
---
L
D
Y
E
G
M
V
R
E
A
-
R
E
L
A
Q
I
--
S
-------
E
Y
-------
V
V
I
K
I
P
M
T
P
D
G
I
K
A
V
K
T
L
S
-
A
E
G
I
K
T
N
V
T
L
V
F
S
P
A
Q
A
I
L
A
A
K
A
G
A
T
-----------------
Y
V
S
P
F
V
G
R
M
D
D
--------------
L
---------
S
--------------
N
----------
D
--
G
M
R
M
L
G
E
I
V
E
I
Y
N
N
Y
------------
G
F
-
E
T
E
I
I
A
A
S
--
I
R
H
P
M
H
V
V
E
---
A
A
L
M
G
V
D
I
V
-
T
M
P
F
A
V
L
E
K
L
F
K
H
P
M
T
D
L
G
I
E
R
F
M
E
D
----------
89
HHSearch
92.07
53%
-117
* C3 *
1WX0
-
TAL_THET8
A:
[1-211]
M
E
L
Y
L
D
T
A
S
L
E
-----
E
I
R
E
I
A
A
W
G
V
L
S
G
V
T
T
N
P
T
L
V
A
K
A
---------
F
A
A
K
GE----------------
A
LT
E
E
A
F
A
--------------------
A
----------------------
H
----
L
R
---------------------------------
A
I
----
C
--------
E
T
---------
V
-
G
G
P
V
S
A
E
V
---
T
A
---
L
E
A
E
A
M
V
A
E
G
-
R
R
L
A
A
I
--
H
-------
P
N
-------
I
V
V
K
L
P
T
T
E
E
G
L
K
A
C
K
R
L
S
-
A
E
G
I
K
V
N
M
T
L
I
F
S
A
N
Q
A
L
L
A
A
R
A
G
A
S
-----------------
Y
V
S
P
F
L
G
R
V
D
D
--------------
I
---------
S
--------------
W
----------
D
--
G
G
E
L
L
R
E
I
V
E
M
I
Q
V
Q
------------
D
L
-
P
V
K
V
I
A
A
S
--
I
R
H
P
R
H
V
T
E
---
A
A
L
L
G
A
D
I
A
-
T
M
P
H
A
V
F
K
Q
L
L
K
H
P
L
T
D
I
G
L
----------------
7
PsiBlast_PDB
91.76
51%
-116
- C3 -
1WX0
-
TAL_THET8
A:
[1-211]
M
E
L
Y
L
D
T
A
S
L
E
-----
E
I
R
E
I
A
A
W
G
V
L
S
G
V
T
T
N
P
T
L
V
A
K
A
F
A
A
K
GEALT
E
E
--------------------
A
-----
F
A
--------------------
A
----------------------
H
----
L
R
---------------------------------
A
I
----
C
--------
E
T
---------
V
-
G
G
P
V
S
A
E
V
---
T
A
---
L
E
A
E
A
M
V
A
E
G
-
R
R
L
A
A
I
--
H
-------
P
N
-------
I
V
V
K
L
P
T
T
E
E
G
L
K
A
C
K
R
L
S
-
A
E
G
I
K
V
N
M
T
L
I
F
S
A
N
Q
A
L
L
A
A
R
A
G
A
S
-----------------
Y
V
S
P
F
L
G
R
V
D
D
--------------
I
---------
S
--------------
W
----------
D
--
G
G
E
L
L
R
E
I
V
E
M
I
Q
V
Q
------------
D
L
-
P
V
K
V
I
A
A
S
--
I
R
H
P
R
H
V
T
E
---
A
A
L
L
G
A
D
I
A
-
T
M
P
H
A
V
F
K
Q
L
L
K
H
P
L
T
D
I
G
L
----------------
66
PsiBlast_CBE
91.62
50%
-115
- C3 -
3S1U
2
TAL_THEAC
D:
[1-216]
M
K
I
F
L
D
T
A
N
I
D
-----
E
I
R
T
G
V
N
W
G
I
V
D
G
V
T
T
N
P
T
L
I
S
K
E
AVN------
G
K
--------------------
K
-----
Y
G
--------------------
D
----------------------
I
----
I
R
---------------------------------
E
I
----
L
--------
K
I
---------
V
-
D
G
P
V
S
V
E
V
---
V
S
---
T
K
Y
E
G
M
V
E
E
A
-
R
K
I
H
G
L
--
G
-------
D
N
-------
A
V
V
K
I
P
M
T
E
D
G
L
R
A
I
K
T
L
S
-
S
E
H
I
N
T
N
C
T
L
V
F
N
P
I
Q
A
L
L
A
A
K
A
G
V
T
-----------------
Y
V
S
P
F
V
G
R
L
D
D
--------------
I
---------
G
--------------
E
----------
D
--
G
M
Q
I
I
D
M
I
R
T
I
F
N
N
Y
------------
I
I
-
K
T
Q
I
L
V
A
S
--
I
R
N
P
I
H
V
L
R
---
S
A
V
I
G
A
D
V
V
-
T
V
P
F
N
V
L
K
S
L
M
K
H
P
K
T
D
E
G
L
A
K
F
L
E
D
W
K
K
V
S
-----
86
HHSearch
90.63
55%
-122
- C3 -
1VPX
-
TAL_THEMA
A:
[13-228]
M
K
I
F
L
D
T
A
N
L
E
-----
E
I
K
K
G
V
E
W
G
I
V
D
G
V
T
T
N
P
-----------------------------------------------------------------
Q
----------------------
R
----
V
K
---------------------------------
E
I
----
C
--------
D
L
---------
V
-
K
G
P
V
S
A
E
V
---
V
S
---
L
D
Y
E
G
M
V
R
E
A
-
R
E
L
A
Q
I
--
S
-------
E
Y
-------
V
V
I
K
I
P
M
T
P
D
G
I
K
A
V
K
T
L
S
-
A
E
G
I
K
T
N
V
T
L
V
F
S
P
A
Q
A
I
L
A
A
K
A
G
A
T
-----------------
Y
V
S
P
F
V
G
R
M
D
D
--------------
L
---------
S
--------------
N
----------
D
--
G
M
R
M
L
G
E
I
V
E
I
Y
N
N
Y
------------
G
F
-
E
T
E
I
I
A
A
S
--
I
R
H
P
M
H
V
V
E
---
A
A
L
M
G
V
D
I
V
-
T
M
P
F
A
V
L
E
K
L
F
K
H
P
M
T
D
L
G
I
E
R
F
M
E
D
W
K
K
Y
L
E
N
L
--
65
PsiBlast_CBE
90.55
50%
-114
- C3 -
3S1U
1
TAL_THEAC
E:
[1-216]
M
K
I
F
L
D
T
A
N
I
D
-----
E
I
R
T
G
V
N
W
G
I
V
D
G
V
T
T
N
P
T
L
I
S
K
E
AVN------
G
K
--------------------
K
-----
Y
G
--------------------
D
----------------------
I
----
I
R
---------------------------------
E
I
----
L
--------
K
I
---------
V
-
D
G
P
V
S
V
E
V
---
V
S
---
T
K
Y
E
G
M
V
E
E
A
-
R
K
I
H
G
L
--
G
-------
D
N
-------
A
V
V
K
I
P
M
T
E
D
G
L
R
A
I
K
T
L
S
-
S
E
H
I
N
T
N
C
T
L
V
F
N
P
I
Q
A
L
L
A
A
K
A
G
V
T
-----------------
Y
V
S
P
F
V
G
R
L
D
D
--------------
I
---------
G
--------------
E
----------
D
--
G
M
Q
I
I
D
M
I
R
T
I
F
N
N
Y
------------
I
I
-
K
T
Q
I
L
V
A
S
--
I
R
N
P
I
H
V
L
R
---
S
A
V
I
G
A
D
V
V
-
T
V
P
F
N
V
L
K
S
L
M
K
H
P
K
T
D
E
G
L
A
K
F
L
E
D
W
K
K
V
S
-----
55
PsiBlast_CBE
90.31
58%
-118
- C3 -
3R8R
1
TAL_BACSU
C:
[1-210]
M
L
F
F
V
D
T
A
N
I
D
-----
E
I
R
E
A
N
E
L
G
I
L
A
G
V
T
T
N
P
S
L
-----------------------------------------
F
H
--------------------
D
----------------------
R
----
L
R
---------------------------------
E
I
----
T
--------
D
V
---------
V
-
K
G
S
V
S
A
E
V
---
I
S
---
L
K
A
E
E
M
I
E
E
G
-
K
E
L
A
K
I
--
A
-------
P
N
-------
I
T
V
K
I
P
M
T
S
D
G
L
K
A
V
R
A
L
T
-
D
L
G
I
K
T
N
V
T
L
I
F
N
A
N
Q
A
L
L
A
A
R
A
G
A
T
-----------------
Y
V
S
P
F
L
G
R
L
D
D
--------------
I
---------
G
--------------
H
----------
N
--
G
L
D
L
I
S
E
V
K
Q
I
F
D
I
H
------------
G
L
-
D
T
Q
I
I
A
A
S
--
I
R
H
P
Q
H
V
T
E
---
A
A
L
R
G
A
H
I
G
-
T
M
P
L
K
V
I
H
A
L
T
K
H
P
L
T
D
K
G
I
E
Q
F
L
A
D
W
---------
1
PsiBlast_PDB
90.31
56%
-124
- C3 -
1VPX
-
TAL_THEMA
A:
[13-224]
M
K
I
F
L
D
T
A
N
L
E
-----
E
I
K
K
G
V
E
W
G
I
V
D
G
V
T
T
N
P
-----------------------------------------------------------------
Q
----------------------
R
----
V
K
---------------------------------
E
I
----
C
--------
D
L
---------
V
-
K
G
P
V
S
A
E
V
---
V
S
---
L
D
Y
E
G
M
V
R
E
A
-
R
E
L
A
Q
I
--
S
-------
E
Y
-------
V
V
I
K
I
P
M
T
P
D
G
I
K
A
V
K
T
L
S
-
A
E
G
I
K
T
N
V
T
L
V
F
S
P
A
Q
A
I
L
A
A
K
A
G
A
T
-----------------
Y
V
S
P
F
V
G
R
M
D
D
--------------
L
---------
S
--------------
N
----------
D
--
G
M
R
M
L
G
E
I
V
E
I
Y
N
N
Y
------------
G
F
-
E
T
E
I
I
A
A
S
--
I
R
H
P
M
H
V
V
E
---
A
A
L
M
G
V
D
I
V
-
T
M
P
F
A
V
L
E
K
L
F
K
H
P
M
T
D
L
G
I
E
R
F
M
E
D
W
K
K
Y
------
39
PsiBlast_CBE
90.15
56%
-115
- C3 -
1VPX
1
TAL_THEMA
B:
[13-219]
M
K
I
F
L
D
T
A
N
L
E
-----
E
I
K
K
G
V
E
W
G
I
V
D
G
V
T
T
N
P
T
L
I
S
K
E
---------
G
A
--------------------
E
-----
F
K
--------------------
Q
----------------------
R
----
V
K
---------------------------------
E
I
----
C
--------
D
L
---------
V
-
K
G
P
V
S
A
E
V
---
V
S
---
L
D
Y
E
G
M
V
R
E
A
-
R
E
L
A
Q
I
--
S
-------
E
Y
-------
V
V
I
K
I
P
M
T
P
D
G
I
K
A
V
K
T
L
S
-
A
E
G
I
K
T
N
V
T
L
V
F
S
P
A
Q
A
I
L
A
A
K
A
G
A
T
-----------------
Y
V
S
P
F
V
G
R
M
D
D
--------------
L
---------
S
--------------
N
----------
D
--
G
M
R
M
L
G
E
I
V
E
I
Y
N
N
Y
------------
G
F
-
E
T
E
I
I
A
A
S
--
I
R
H
P
M
H
V
V
E
---
A
A
L
M
G
V
D
I
V
-
T
M
P
F
A
V
L
E
K
L
F
K
H
P
M
T
D
L
G
I
E
R
F
M
E
-----------
4
PsiBlast_PDB
90.08
50%
-115
- C3 -
3S1U
1
TAL_THEAC
A:
[1-216]
M
K
I
F
L
D
T
A
N
I
D
-----
E
I
R
T
G
V
N
W
G
I
V
D
G
V
T
T
N
P
T
L
I
S
K
E
AVN------
G
K
--------------------
K
-----
Y
G
--------------------
D
----------------------
I
----
I
R
---------------------------------
E
I
----
L
--------
K
I
---------
V
-
D
G
P
V
S
V
E
V
---
V
S
---
T
K
Y
E
G
M
V
E
E
A
-
R
K
I
H
G
L
--
G
-------
D
N
-------
A
V
V
K
I
P
M
T
E
D
G
L
R
A
I
K
T
L
S
-
S
E
H
I
N
T
N
C
T
L
V
F
N
P
I
Q
A
L
L
A
A
K
A
G
V
T
-----------------
Y
V
S
P
F
V
G
R
L
D
D
--------------
I
---------
G
--------------
E
----------
D
--
G
M
Q
I
I
D
M
I
R
T
I
F
N
N
Y
------------
I
I
-
K
T
Q
I
L
V
A
S
--
I
R
N
P
I
H
V
L
R
---
S
A
V
I
G
A
D
V
V
-
T
V
P
F
N
V
L
K
S
L
M
K
H
P
K
T
D
E
G
L
A
K
F
L
E
D
W
K
K
V
S
-----
23
PsiBlast_CBE
89.51
56%
-121
- C3 -
1VPX
1
TAL_THEMA
R:
[13-224]
M
K
I
F
L
D
T
A
N
L
E
-----
E
I
K
K
G
V
E
W
G
I
V
D
G
V
T
T
N
P
T
---------------
A
--------------------
E
-----
F
K
--------------------
Q
----------------------
R
----
V
K
---------------------------------
E
I
----
C
--------
D
L
---------
V
-
K
G
P
V
S
A
E
V
---
V
S
---
L
D
Y
E
G
M
V
R
E
A
-
R
E
L
A
Q
I
--
S
-------
E
Y
-------
V
V
I
K
I
P
M
T
P
D
G
I
K
A
V
K
T
L
S
-
A
E
G
I
K
T
N
V
T
L
V
F
S
P
A
Q
A
I
L
A
A
K
A
G
A
T
-----------------
Y
V
S
P
F
V
G
R
M
D
D
--------------
L
---------
S
--------------
N
----------
D
--
G
M
R
M
L
G
E
I
V
E
I
Y
N
N
Y
------------
G
F
-
E
T
E
I
I
A
A
S
--
I
R
H
P
M
H
V
V
E
---
A
A
L
M
G
V
D
I
V
-
T
M
P
F
A
V
L
E
K
L
F
K
H
P
M
T
D
L
G
I
E
R
F
M
E
D
W
K
K
Y
------
69
PsiBlast_CBE
89.23
50%
-110
- C3 -
3S1W
2
TAL_THEAC
E:
[1-216]
M
K
I
F
L
D
T
A
N
I
D
-----
E
I
R
T
G
V
N
W
G
I
V
D
G
V
T
T
N
P
T
L
I
S
K
E
AVN------
G
K
--------------------
K
-----
Y
G
--------------------
D
----------------------
I
----
I
R
---------------------------------
E
I
----
L
--------
K
I
---------
V
-
D
G
P
V
S
V
E
V
---
V
S
---
T
K
Y
E
G
M
V
E
E
A
-
R
K
I
H
G
L
--
G
-------
D
N
-------
A
V
V
A
I
P
M
T
E
D
G
L
R
A
I
K
T
L
S
-
S
E
H
I
N
T
N
C
T
L
V
F
N
P
I
Q
A
L
L
A
A
K
A
G
V
T
-----------------
Y
V
S
P
F
V
G
R
L
D
D
--------------
I
---------
G
--------------
E
----------
D
--
G
M
Q
I
I
D
M
I
R
T
I
F
N
N
Y
------------
I
I
-
K
T
Q
I
L
V
A
S
--
I
R
N
P
I
H
V
L
R
---
S
A
V
I
G
A
D
V
V
-
T
V
P
F
N
V
L
K
S
L
M
K
H
P
K
T
D
E
G
L
A
K
F
L
E
D
W
K
K
V
S
-----
70
PsiBlast_CBE
88.84
50%
-109
- C3 -
3S1W
2
TAL_THEAC
D:
[1-216]
M
K
I
F
L
D
T
A
N
I
D
-----
E
I
R
T
G
V
N
W
G
I
V
D
G
V
T
T
N
P
T
L
I
S
K
E
AVN------
G
K
--------------------
K
-----
Y
G
--------------------
D
----------------------
I
----
I
R
---------------------------------
E
I
----
L
--------
K
I
---------
V
-
D
G
P
V
S
V
E
V
---
V
S
---
T
K
Y
E
G
M
V
E
E
A
-
R
K
I
H
G
L
--
G
-------
D
N
-------
A
V
V
A
I
P
M
T
E
D
G
L
R
A
I
K
T
L
S
-
S
E
H
I
N
T
N
C
T
L
V
F
N
P
I
Q
A
L
L
A
A
K
A
G
V
T
-----------------
Y
V
S
P
F
V
G
R
L
D
D
--------------
I
---------
G
--------------
E
----------
D
--
G
M
Q
I
I
D
M
I
R
T
I
F
N
N
Y
------------
I
I
-
K
T
Q
I
L
V
A
S
--
I
R
N
P
I
H
V
L
R
---
S
A
V
I
G
A
D
V
V
-
T
V
P
F
N
V
L
K
S
L
M
K
H
P
K
T
D
E
G
L
A
K
F
L
E
D
W
K
K
V
S
-----
3
PsiBlast_PDB
88.78
50%
-111
- C3 -
3S0C
1
TAL_THEAC
A:
[1-216]
M
K
I
F
L
D
T
A
N
I
D
-----
E
I
R
T
G
V
N
W
G
I
V
D
G
V
T
T
N
P
T
L
I
S
K
E
AVN------
G
K
--------------------
K
-----
Y
G
--------------------
D
----------------------
I
----
I
R
---------------------------------
E
I
----
L
--------
K
I
---------
V
-
D
G
P
V
S
V
E
V
---
V
S
---
T
K
Y
E
G
M
V
E
E
A
-
R
K
I
H
G
L
--
G
-------
D
N
-------
A
V
V
K
I
P
M
T
E
D
G
L
R
A
I
K
T
L
S
-
S
E
H
I
N
T
N
C
T
L
V
F
N
P
I
Q
A
L
L
A
A
K
A
G
V
T
-----------------
Y
V
S
P
F
V
G
R
L
D
D
--------------
I
---------
G
--------------
E
----------
D
--
G
M
Q
I
I
D
M
I
R
T
I
F
N
N
Y
------------
I
I
-
K
T
Q
I
L
V
A
S
--
I
R
N
P
I
H
V
L
R
---
S
A
V
I
G
A
D
V
V
-
T
V
P
F
N
V
L
K
S
L
M
K
H
P
K
T
D
E
G
L
A
K
F
L
E
D
W
K
K
V
S
-----
64
PsiBlast_CBE
88.75
50%
-113
- C3 -
3S1V
2
TAL_THEAC
B:
[1-216]
M
K
I
F
L
D
T
A
N
I
D
-----
E
I
R
T
G
V
N
W
G
I
V
D
G
V
T
T
N
P
T
L
I
S
K
E
AVN------
G
K
--------------------
K
-----
Y
G
--------------------
D
----------------------
I
----
I
R
---------------------------------
E
I
----
L
--------
K
I
---------
V
-
D
G
P
V
S
V
E
V
---
V
S
---
T
K
Y
E
G
M
V
E
E
A
-
R
K
I
H
G
L
--
G
-------
D
N
-------
A
V
V
K
I
P
M
T
E
D
G
L
R
A
I
K
T
L
S
-
S
E
H
I
N
T
N
C
T
L
V
F
N
P
I
Q
A
L
L
A
A
K
A
G
V
T
-----------------
Y
V
S
P
F
V
G
R
L
D
D
--------------
I
---------
G
--------------
E
----------
D
--
G
M
Q
I
I
D
M
I
R
T
I
F
N
N
Y
------------
I
I
-
K
T
Q
I
L
V
A
S
--
I
R
N
P
I
H
V
L
R
---
S
A
V
I
G
A
D
V
V
-
T
V
P
F
N
V
L
K
S
L
M
K
H
P
K
T
D
E
G
L
A
K
F
L
E
D
W
K
K
V
S
-----
61
PsiBlast_CBE
88.73
50%
-112
- C3 -
3S1V
1
TAL_THEAC
E:
[1-216]
M
K
I
F
L
D
T
A
N
I
D
-----
E
I
R
T
G
V
N
W
G
I
V
D
G
V
T
T
N
P
T
L
I
S
K
E
AVN------
G
K
--------------------
K
-----
Y
G
--------------------
D
----------------------
I
----
I
R
---------------------------------
E
I
----
L
--------
K
I
---------
V
-
D
G
P
V
S
V
E
V
---
V
S
---
T
K
Y
E
G
M
V
E
E
A
-
R
K
I
H
G
L
--
G
-------
D
N
-------
A
V
V
K
I
P
M
T
E
D
G
L
R
A
I
K
T
L
S
-
S
E
H
I
N
T
N
C
T
L
V
F
N
P
I
Q
A
L
L
A
A
K
A
G
V
T
-----------------
Y
V
S
P
F
V
G
R
L
D
D
--------------
I
---------
G
--------------
E
----------
D
--
G
M
Q
I
I
D
M
I
R
T
I
F
N
N
Y
------------
I
I
-
K
T
Q
I
L
V
A
S
--
I
R
N
P
I
H
V
L
R
---
S
A
V
I
G
A
D
V
V
-
T
V
P
F
N
V
L
K
S
L
M
K
H
P
K
T
D
E
G
L
A
K
F
L
E
D
W
K
K
V
S
-----
63
PsiBlast_CBE
88.64
50%
-112
- C3 -
3S1V
1
TAL_THEAC
C:
[1-216]
M
K
I
F
L
D
T
A
N
I
D
-----
E
I
R
T
G
V
N
W
G
I
V
D
G
V
T
T
N
P
T
L
I
S
K
E
AVN------
G
K
--------------------
K
-----
Y
G
--------------------
D
----------------------
I
----
I
R
---------------------------------
E
I
----
L
--------
K
I
---------
V
-
D
G
P
V
S
V
E
V
---
V
S
---
T
K
Y
E
G
M
V
E
E
A
-
R
K
I
H
G
L
--
G
-------
D
N
-------
A
V
V
K
I
P
M
T
E
D
G
L
R
A
I
K
T
L
S
-
S
E
H
I
N
T
N
C
T
L
V
F
N
P
I
Q
A
L
L
A
A
K
A
G
V
T
-----------------
Y
V
S
P
F
V
G
R
L
D
D
--------------
I
---------
G
--------------
E
----------
D
--
G
M
Q
I
I
D
M
I
R
T
I
F
N
N
Y
------------
I
I
-
K
T
Q
I
L
V
A
S
--
I
R
N
P
I
H
V
L
R
---
S
A
V
I
G
A
D
V
V
-
T
V
P
F
N
V
L
K
S
L
M
K
H
P
K
T
D
E
G
L
A
K
F
L
E
D
W
K
K
V
S
-----
58
PsiBlast_CBE
88.53
50%
-111
- C3 -
3S1X
2
TAL_THEAC
D:
[1-216]
M
K
I
F
L
D
T
A
N
I
D
-----
E
I
R
T
G
V
N
W
G
I
V
D
G
V
T
T
N
P
T
L
I
S
K
E
AVN------
G
K
--------------------
K
-----
Y
G
--------------------
D
----------------------
I
----
I
R
---------------------------------
E
I
----
L
--------
K
I
---------
V
-
D
G
P
V
S
V
E
V
---
V
S
---
T
K
Y
E
G
M
V
E
E
A
-
R
K
I
H
G
L
--
G
-------
D
N
-------
A
V
V
K
I
P
M
T
E
D
G
L
R
A
I
K
T
L
S
-
S
E
H
I
N
T
N
C
T
L
V
F
N
P
I
Q
A
L
L
A
A
K
A
G
V
T
-----------------
Y
V
S
P
F
V
G
R
L
D
D
--------------
I
---------
G
--------------
E
----------
D
--
G
M
Q
I
I
D
M
I
R
T
I
F
N
N
Y
------------
I
I
-
K
T
Q
I
L
V
A
S
--
I
R
N
P
I
H
V
L
R
---
S
A
V
I
G
A
D
V
V
-
T
V
P
F
N
V
L
K
S
L
M
K
H
P
K
T
D
E
G
L
A
K
F
L
E
D
W
K
K
V
S
-----
71
PsiBlast_CBE
88.51
50%
-106
- C3 -
3S1W
2
TAL_THEAC
C:
[1-216]
M
K
I
F
L
D
T
A
N
I
D
-----
E
I
R
T
G
V
N
W
G
I
V
D
G
V
T
T
N
P
T
L
I
S
K
E
AVN------
G
K
--------------------
K
-----
Y
G
--------------------
D
----------------------
I
----
I
R
---------------------------------
E
I
----
L
--------
K
I
---------
V
-
D
G
P
V
S
V
E
V
---
V
S
---
T
K
Y
E
G
M
V
E
E
A
-
R
K
I
H
G
L
--
G
-------
D
N
-------
A
V
V
A
I
P
M
T
E
D
G
L
R
A
I
K
T
L
S
-
S
E
H
I
N
T
N
C
T
L
V
F
N
P
I
Q
A
L
L
A
A
K
A
G
V
T
-----------------
Y
V
S
P
F
V
G
R
L
D
D
--------------
I
---------
G
--------------
E
----------
D
--
G
M
Q
I
I
D
M
I
R
T
I
F
N
N
Y
------------
I
I
-
K
T
Q
I
L
V
A
S
--
I
R
N
P
I
H
V
L
R
---
S
A
V
I
G
A
D
V
V
-
T
V
P
F
N
V
L
K
S
L
M
K
H
P
K
T
D
E
G
L
A
K
F
L
E
D
W
K
K
V
S
-----
88
HHSearch
88.48
50%
-110
- C3 -
3S1X
1
TAL_THEAC
A:
[1-219]
M
K
I
F
L
D
T
A
N
I
D
-----
E
I
R
T
G
V
N
W
G
I
V
D
G
V
T
T
N
P
T
L
I
S
K
E
---------
A
V
--------------------
N
GKK--
Y
G
--------------------
D
----------------------
I
----
I
R
---------------------------------
E
I
----
L
--------
K
I
---------
V
-
D
G
P
V
S
V
E
V
---
V
S
---
T
K
Y
E
G
M
V
E
E
A
-
R
K
I
H
G
L
--
G
-------
D
N
-------
A
V
V
K
I
P
M
T
E
D
G
L
R
A
I
K
T
L
S
-
S
E
H
I
N
T
N
C
T
L
V
F
N
P
I
Q
A
L
L
A
A
K
A
G
V
T
-----------------
Y
V
S
P
F
V
G
R
L
D
D
--------------
I
---------
G
--------------
E
----------
D
--
G
M
Q
I
I
D
M
I
R
T
I
F
N
N
Y
------------
I
I
-
K
T
Q
I
L
V
A
S
--
I
R
N
P
I
H
V
L
R
---
S
A
V
I
G
A
D
V
V
-
T
V
P
F
N
V
L
K
S
L
M
K
H
P
K
T
D
E
G
L
A
K
F
L
E
D
W
K
K
V
S
P
D
G
--
59
PsiBlast_CBE
88.34
50%
-112
- C3 -
3S1X
1
TAL_THEAC
C:
[1-216]
M
K
I
F
L
D
T
A
N
I
D
-----
E
I
R
T
G
V
N
W
G
I
V
D
G
V
T
T
N
P
T
L
I
S
K
E
AVN------
G
K
--------------------
K
-----
Y
G
--------------------
D
----------------------
I
----
I
R
---------------------------------
E
I
----
L
--------
K
I
---------
V
-
D
G
P
V
S
V
E
V
---
V
S
---
T
K
Y
E
G
M
V
E
E
A
-
R
K
I
H
G
L
--
G
-------
D
N
-------
A
V
V
K
I
P
M
T
E
D
G
L
R
A
I
K
T
L
S
-
S
E
H
I
N
T
N
C
T
L
V
F
N
P
I
Q
A
L
L
A
A
K
A
G
V
T
-----------------
Y
V
S
P
F
V
G
R
L
D
D
--------------
I
---------
G
--------------
E
----------
D
--
G
M
Q
I
I
D
M
I
R
T
I
F
N
N
Y
------------
I
I
-
K
T
Q
I
L
V
A
S
--
I
R
N
P
I
H
V
L
R
---
S
A
V
I
G
A
D
V
V
-
T
V
P
F
N
V
L
K
S
L
M
K
H
P
K
T
D
E
G
L
A
K
F
L
E
D
W
K
K
V
S
-----
6
PsiBlast_PDB
88.17
50%
-110
- C3 -
3S1X
1
TAL_THEAC
A:
[1-216]
M
K
I
F
L
D
T
A
N
I
D
-----
E
I
R
T
G
V
N
W
G
I
V
D
G
V
T
T
N
P
T
L
I
S
K
E
AVN------
G
K
--------------------
K
-----
Y
G
--------------------
D
----------------------
I
----
I
R
---------------------------------
E
I
----
L
--------
K
I
---------
V
-
D
G
P
V
S
V
E
V
---
V
S
---
T
K
Y
E
G
M
V
E
E
A
-
R
K
I
H
G
L
--
G
-------
D
N
-------
A
V
V
K
I
P
M
T
E
D
G
L
R
A
I
K
T
L
S
-
S
E
H
I
N
T
N
C
T
L
V
F
N
P
I
Q
A
L
L
A
A
K
A
G
V
T
-----------------
Y
V
S
P
F
V
G
R
L
D
D
--------------
I
---------
G
--------------
E
----------
D
--
G
M
Q
I
I
D
M
I
R
T
I
F
N
N
Y
------------
I
I
-
K
T
Q
I
L
V
A
S
--
I
R
N
P
I
H
V
L
R
---
S
A
V
I
G
A
D
V
V
-
T
V
P
F
N
V
L
K
S
L
M
K
H
P
K
T
D
E
G
L
A
K
F
L
E
D
W
K
K
V
S
-----
67
PsiBlast_CBE
88.15
50%
-110
- C3 -
3S1U
2
TAL_THEAC
C:
[1-216]
M
K
I
F
L
D
T
A
N
I
D
-----
E
I
R
T
G
V
N
W
G
I
V
D
G
V
T
T
N
P
T
L
I
S
K
E
AVN------
G
K
--------------------
K
-----
Y
G
--------------------
D
----------------------
I
----
I
R
---------------------------------
E
I
----
L
--------
K
I
---------
V
-
D
G
P
V
S
V
E
V
---
V
S
---
T
K
Y
E
G
M
V
E
E
A
-
R
K
I
H
G
L
--
G
-------
D
N
-------
A
V
V
K
I
P
M
T
E
D
G
L
R
A
I
K
T
L
S
-
S
E
H
I
N
T
N
C
T
L
V
F
N
P
I
Q
A
L
L
A
A
K
A
G
V
T
-----------------
Y
V
S
P
F
V
G
R
L
D
D
--------------
I
---------
G
--------------
E
----------
D
--
G
M
Q
I
I
D
M
I
R
T
I
F
N
N
Y
------------
I
I
-
K
T
Q
I
L
V
A
S
--
I
R
N
P
I
H
V
L
R
---
S
A
V
I
G
A
D
V
V
-
T
V
P
F
N
V
L
K
S
L
M
K
H
P
K
T
D
E
G
L
A
K
F
L
E
D
W
K
K
V
S
-----
72
PsiBlast_CBE
88.00
50%
-111
- C3 -
3S1W
2
TAL_THEAC
B:
[1-216]
M
K
I
F
L
D
T
A
N
I
D
-----
E
I
R
T
G
V
N
W
G
I
V
D
G
V
T
T
N
P
T
L
I
S
K
E
AVN------
G
K
--------------------
K
-----
Y
G
--------------------
D
----------------------
I
----
I
R
---------------------------------
E
I
----
L
--------
K
I
---------
V
-
D
G
P
V
S
V
E
V
---
V
S
---
T
K
Y
E
G
M
V
E
E
A
-
R
K
I
H
G
L
--
G
-------
D
N
-------
A
V
V
A
I
P
M
T
E
D
G
L
R
A
I
K
T
L
S
-
S
E
H
I
N
T
N
C
T
L
V
F
N
P
I
Q
A
L
L
A
A
K
A
G
V
T
-----------------
Y
V
S
P
F
V
G
R
L
D
D
--------------
I
---------
G
--------------
E
----------
D
--
G
M
Q
I
I
D
M
I
R
T
I
F
N
N
Y
------------
I
I
-
K
T
Q
I
L
V
A
S
--
I
R
N
P
I
H
V
L
R
---
S
A
V
I
G
A
D
V
V
-
T
V
P
F
N
V
L
K
S
L
M
K
H
P
K
T
D
E
G
L
A
K
F
L
E
D
W
K
K
V
S
-----
62
PsiBlast_CBE
87.96
50%
-112
- C3 -
3S1V
2
TAL_THEAC
D:
[1-216]
M
K
I
F
L
D
T
A
N
I
D
-----
E
I
R
T
G
V
N
W
G
I
V
D
G
V
T
T
N
P
T
L
I
S
K
E
AVN------
G
K
--------------------
K
-----
Y
G
--------------------
D
----------------------
I
----
I
R
---------------------------------
E
I
----
L
--------
K
I
---------
V
-
D
G
P
V
S
V
E
V
---
V
S
---
T
K
Y
E
G
M
V
E
E
A
-
R
K
I
H
G
L
--
G
-------
D
N
-------
A
V
V
K
I
P
M
T
E
D
G
L
R
A
I
K
T
L
S
-
S
E
H
I
N
T
N
C
T
L
V
F
N
P
I
Q
A
L
L
A
A
K
A
G
V
T
-----------------
Y
V
S
P
F
V
G
R
L
D
D
--------------
I
---------
G
--------------
E
----------
D
--
G
M
Q
I
I
D
M
I
R
T
I
F
N
N
Y
------------
I
I
-
K
T
Q
I
L
V
A
S
--
I
R
N
P
I
H
V
L
R
---
S
A
V
I
G
A
D
V
V
-
T
V
P
F
N
V
L
K
S
L
M
K
H
P
K
T
D
E
G
L
A
K
F
L
E
D
W
K
K
V
S
-----
68
PsiBlast_CBE
87.74
50%
-112
- C3 -
3S1U
1
TAL_THEAC
B:
[1-216]
M
K
I
F
L
D
T
A
N
I
D
-----
E
I
R
T
G
V
N
W
G
I
V
D
G
V
T
T
N
P
T
L
I
S
K
E
AVN------
G
K
--------------------
K
-----
Y
G
--------------------
D
----------------------
I
----
I
R
---------------------------------
E
I
----
L
--------
K
I
---------
V
-
D
G
P
V
S
V
E
V
---
V
S
---
T
K
Y
E
G
M
V
E
E
A
-
R
K
I
H
G
L
--
G
-------
D
N
-------
A
V
V
K
I
P
M
T
E
D
G
L
R
A
I
K
T
L
S
-
S
E
H
I
N
T
N
C
T
L
V
F
N
P
I
Q
A
L
L
A
A
K
A
G
V
T
-----------------
Y
V
S
P
F
V
G
R
L
D
D
--------------
I
---------
G
--------------
E
----------
D
--
G
M
Q
I
I
D
M
I
R
T
I
F
N
N
Y
------------
I
I
-
K
T
Q
I
L
V
A
S
--
I
R
N
P
I
H
V
L
R
---
S
A
V
I
G
A
D
V
V
-
T
V
P
F
N
V
L
K
S
L
M
K
H
P
K
T
D
E
G
L
A
K
F
L
E
D
W
K
K
V
S
-----
8
PsiBlast_PDB
87.74
50%
-109
- C3 -
3S1W
2
TAL_THEAC
A:
[1-216]
M
K
I
F
L
D
T
A
N
I
D
-----
E
I
R
T
G
V
N
W
G
I
V
D
G
V
T
T
N
P
T
L
I
S
K
E
AVN------
G
K
--------------------
K
-----
Y
G
--------------------
D
----------------------
I
----
I
R
---------------------------------
E
I
----
L
--------
K
I
---------
V
-
D
G
P
V
S
V
E
V
---
V
S
---
T
K
Y
E
G
M
V
E
E
A
-
R
K
I
H
G
L
--
G
-------
D
N
-------
A
V
V
A
I
P
M
T
E
D
G
L
R
A
I
K
T
L
S
-
S
E
H
I
N
T
N
C
T
L
V
F
N
P
I
Q
A
L
L
A
A
K
A
G
V
T
-----------------
Y
V
S
P
F
V
G
R
L
D
D
--------------
I
---------
G
--------------
E
----------
D
--
G
M
Q
I
I
D
M
I
R
T
I
F
N
N
Y
------------
I
I
-
K
T
Q
I
L
V
A
S
--
I
R
N
P
I
H
V
L
R
---
S
A
V
I
G
A
D
V
V
-
T
V
P
F
N
V
L
K
S
L
M
K
H
P
K
T
D
E
G
L
A
K
F
L
E
D
W
K
K
V
S
-----
60
PsiBlast_CBE
87.64
50%
-110
- C3 -
3S1X
1
TAL_THEAC
B:
[1-216]
M
K
I
F
L
D
T
A
N
I
D
-----
E
I
R
T
G
V
N
W
G
I
V
D
G
V
T
T
N
P
T
L
I
S
K
E
AVN------
G
K
--------------------
K
-----
Y
G
--------------------
D
----------------------
I
----
I
R
---------------------------------
E
I
----
L
--------
K
I
---------
V
-
D
G
P
V
S
V
E
V
---
V
S
---
T
K
Y
E
G
M
V
E
E
A
-
R
K
I
H
G
L
--
G
-------
D
N
-------
A
V
V
K
I
P
M
T
E
D
G
L
R
A
I
K
T
L
S
-
S
E
H
I
N
T
N
C
T
L
V
F
N
P
I
Q
A
L
L
A
A
K
A
G
V
T
-----------------
Y
V
S
P
F
V
G
R
L
D
D
--------------
I
---------
G
--------------
E
----------
D
--
G
M
Q
I
I
D
M
I
R
T
I
F
N
N
Y
------------
I
I
-
K
T
Q
I
L
V
A
S
--
I
R
N
P
I
H
V
L
R
---
S
A
V
I
G
A
D
V
V
-
T
V
P
F
N
V
L
K
S
L
M
K
H
P
K
T
D
E
G
L
A
K
F
L
E
D
W
K
K
V
S
-----
57
PsiBlast_CBE
87.22
50%
-112
- C3 -
3S1X
2
TAL_THEAC
E:
[1-216]
M
K
I
F
L
D
T
A
N
I
D
-----
E
I
R
T
G
V
N
W
G
I
V
D
G
V
T
T
N
P
T
L
I
S
K
E
AVN------
G
K
--------------------
K
-----
Y
G
--------------------
D
----------------------
I
----
I
R
---------------------------------
E
I
----
L
--------
K
I
---------
V
-
D
G
P
V
S
V
E
V
---
V
S
---
T
K
Y
E
G
M
V
E
E
A
-
R
K
I
H
G
L
--
G
-------
D
N
-------
A
V
V
K
I
P
M
T
E
D
G
L
R
A
I
K
T
L
S
-
S
E
H
I
N
T
N
C
T
L
V
F
N
P
I
Q
A
L
L
A
A
K
A
G
V
T
-----------------
Y
V
S
P
F
V
G
R
L
D
D
--------------
I
---------
G
--------------
E
----------
D
--
G
M
Q
I
I
D
M
I
R
T
I
F
N
N
Y
------------
I
I
-
K
T
Q
I
L
V
A
S
--
I
R
N
P
I
H
V
L
R
---
S
A
V
I
G
A
D
V
V
-
T
V
P
F
N
V
L
K
S
L
M
K
H
P
K
T
D
E
G
L
A
K
F
L
E
D
W
K
K
V
S
-----
5
PsiBlast_PDB
86.90
50%
-111
- C3 -
3S1V
3
TAL_THEAC
A:
[1-216]
M
K
I
F
L
D
T
A
N
I
D
-----
E
I
R
T
G
V
N
W
G
I
V
D
G
V
T
T
N
P
T
L
I
S
K
E
AVN------
G
K
--------------------
K
-----
Y
G
--------------------
D
----------------------
I
----
I
R
---------------------------------
E
I
----
L
--------
K
I
---------
V
-
D
G
P
V
S
V
E
V
---
V
S
---
T
K
Y
E
G
M
V
E
E
A
-
R
K
I
H
G
L
--
G
-------
D
N
-------
A
V
V
K
I
P
M
T
E
D
G
L
R
A
I
K
T
L
S
-
S
E
H
I
N
T
N
C
T
L
V
F
N
P
I
Q
A
L
L
A
A
K
A
G
V
T
-----------------
Y
V
S
P
F
V
G
R
L
D
D
--------------
I
---------
G
--------------
E
----------
D
--
G
M
Q
I
I
D
M
I
R
T
I
F
N
N
Y
------------
I
I
-
K
T
Q
I
L
V
A
S
--
I
R
N
P
I
H
V
L
R
---
S
A
V
I
G
A
D
V
V
-
T
V
P
F
N
V
L
K
S
L
M
K
H
P
K
T
D
E
G
L
A
K
F
L
E
D
W
K
K
V
S
-----
94
HHSearch
68.81
34%
-94
- C3 -
3HJZ
13
TAL_PROM9
A:
[14-260]
-
V
V
V
A
D
T
G
D
L
D
-----
S
I
K
K
F
Q
----
P
R
D
A
T
T
N
P
S
L
I
L
A
A
---------
A
K
--------------------
N
P
D
---
Y
V
--------------------
K
----------------------
L
----
I
D
K
A
I
E
S
S
E
N
T
LPNGFS
E
I
E
L
I
K
E
T
V
D
Q
V
S
V
F
F
G
K
E
I
----
L
--------
K
I
---------
I
-
S
G
R
V
S
T
E
V
---
D
A
RLS
F
D
T
E
A
T
V
K
K
A
-
R
K
L
I
N
L
--
Y
K
N
F
GIEK
E
R
-------
I
L
I
K
I
A
A
T
W
E
G
I
K
A
A
E
I
L
E
-
K
E
G
I
K
C
N
L
T
L
L
F
N
F
C
Q
A
V
T
C
A
N
A
N
I
T
-----------------
L
I
S
P
F
V
G
R
I
L
D
--------------
W
---------
H
K
A
K
TGKTSFIGAE-
D
----------
P
--
G
V
I
S
V
T
Q
I
Y
K
Y
F
K
E
K
------------
G
F
-
K
T
E
V
M
G
A
S
--
F
R
N
L
D
E
I
K
E
-----
L
A
G
C
D
L
L
-
T
I
A
P
K
F
L
E
E
L
K
R
E
K
----------------------
12
PsiBlast_PDB
67.32
31%
-117
- C3 -
3TNO
1
?
A:
[111-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
----
L
--------
D
V
---------
I
-
E
G
K
V
S
S
E
V
DAR
V
S
---
F
N
S
A
T
T
I
D
Y
A
K
R
I
I
A
R
Y
--
E
-------
S
N
GIPKDR-
V
L
I
K
I
A
A
T
W
E
G
I
K
A
A
K
L
L
Q
-
K
E
G
I
N
C
N
L
T
L
I
F
D
K
A
Q
A
K
A
C
A
E
A
G
V
Y
-----------------
L
V
S
P
F
V
G
R
I
T
D
W
Q
M
Q
Q
N
NLKTFPAI
A
---------
D
--------------
D
----------
D
--
G
V
N
S
V
K
A
I
Y
K
L
Y
K
S
H
------------
G
F
-
K
T
I
V
M
G
A
S
--
F
R
N
V
E
Q
V
-----
I
A
L
A
G
C
D
A
L
-
T
I
S
P
V
L
L
E
E
L
--------------------------
11
PsiBlast_PDB
67.30
31%
-116
- C3 -
3TK7
1
?
A:
[111-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
----
L
--------
D
V
---------
I
-
E
G
K
V
S
S
E
V
DAR
V
S
---
F
N
S
A
T
T
I
D
Y
A
K
R
I
I
A
R
Y
--
E
-------
S
N
GIPKDR-
V
L
I
K
I
A
A
T
W
E
G
I
K
A
A
K
L
L
Q
-
K
E
G
I
N
C
N
L
T
L
I
F
D
K
A
Q
A
K
A
C
A
E
A
G
V
Y
-----------------
L
V
S
P
F
V
G
R
I
T
D
W
Q
M
Q
Q
N
NLKTFPAI
A
---------
D
--------------
D
----------
D
--
G
V
N
S
V
K
A
I
Y
K
L
Y
K
S
H
------------
G
F
-
K
T
I
V
M
G
A
S
--
F
R
N
V
E
Q
V
-----
I
A
L
A
G
C
D
A
L
-
T
I
S
P
V
L
L
E
E
L
--------------------------
83
PsiBlast_CBE
66.98
31%
-116
- C3 -
3UPB
1
?
B:
[111-290]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
----
L
--------
D
V
---------
I
-
E
G
K
V
S
S
E
V
DAR
V
S
---
F
N
S
A
T
T
I
D
Y
A
K
R
I
I
A
R
Y
--
E
-------
S
N
GIPKDR-
V
L
I
K
I
A
A
T
W
E
G
I
K
A
A
K
L
L
Q
-
K
E
G
I
N
C
N
L
T
L
I
F
D
K
A
Q
A
K
A
C
A
E
A
G
V
Y
-----------------
L
V
S
P
F
V
G
R
I
T
D
W
Q
M
Q
Q
N
NLKTFPAI
A
---------
D
--------------
D
----------
D
--
G
V
N
S
V
K
A
I
Y
K
L
Y
K
S
H
------------
G
F
-
K
T
I
V
M
G
A
S
--
F
R
N
V
E
Q
V
-----
I
A
L
A
G
C
D
A
L
-
T
I
S
P
V
L
L
E
E
L
--------------------------
91
HHSearch
66.94
30%
-100
- C3 -
3CQ0
13
TAL2_YEAST
A:
[24-269]
T
H
V
V
A
D
S
G
D
F
E
-----
A
I
S
K
Y
E
----
P
Q
D
S
T
T
N
P
S
L
I
L
A
A
---------
S
K
LEKY
A
R
F
I
D
A
A
V
E
Y
G
R
K
H
GK
T
-----
D
H
--------------------
E
----------------------
K
I
E
N
A
M
D
K
I
L
V
E
F
G
T
-------------------------
Q
I
----
L
--------
K
V
---------
V
-
P
G
R
V
S
T
E
V
---
D
A
RLS
F
D
K
K
A
T
V
K
K
A
-
L
H
I
I
K
L
--
Y
K
D
A
GVPK
E
R
-------
V
L
I
K
I
A
S
T
W
E
G
I
Q
A
A
R
E
L
E
V
K
H
G
I
H
C
N
M
T
L
L
F
S
F
T
Q
A
V
A
C
A
E
A
N
V
T
-----------------
L
I
S
P
F
V
G
R
I
M
D
--------------
F
Y
K
A
LDYTAE
T
--------------
D
----------
P
--
G
V
L
S
V
K
K
I
Y
S
Y
Y
K
R
H
------------
G
Y
-
A
T
E
V
M
A
A
S
--
F
R
N
L
D
E
L
K
-----
A
L
A
G
I
D
N
M
-
T
L
P
L
N
L
L
E
Q
L
Y
E
S
T
D
---------------------
13
PsiBlast_PDB
66.48
31%
-116
- C3 -
3UPB
2
?
A:
[111-290]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
----
L
--------
D
V
---------
I
-
E
G
K
V
S
S
E
V
DAR
V
S
---
F
N
S
A
T
T
I
D
Y
A
K
R
I
I
A
R
Y
--
E
-------
S
N
GIPKDR-
V
L
I
K
I
A
A
T
W
E
G
I
K
A
A
K
L
L
Q
-
K
E
G
I
N
C
N
L
T
L
I
F
D
K
A
Q
A
K
A
C
A
E
A
G
V
Y
-----------------
L
V
S
P
F
V
G
R
I
T
D
W
Q
M
Q
Q
N
NLKTFPAI
A
---------
D
--------------
D
----------
D
--
G
V
N
S
V
K
A
I
Y
K
L
Y
K
S
H
------------
G
F
-
K
T
I
V
M
G
A
S
--
F
R
N
V
E
Q
V
-----
I
A
L
A
G
C
D
A
L
-
T
I
S
P
V
L
L
E
E
L
--------------------------
96
HHSearch
65.32
32%
-89
- C3 -
3TKF
6
?
A:
[38-294]
-
M
V
V
A
D
T
G
D
F
E
-----
L
I
K
K
Y
K
P
----
V
D
A
T
T
N
P
S
L
I
L
K
A
---------
V
K
--------------------
E
QK---
Y
S
N
L
V
A
E
T
I
S
K
V
K
A
N
N
PDLN
S
D
D
----------------------
L
----
V
K
---------------------------------
E
I
A
I
E
I
L
V
S
F
G
I
K
I
L
D
V
---------
I
-
E
G
K
V
S
S
E
V
---
D
A
RVS
F
N
S
A
T
T
I
D
Y
A
-
K
R
I
I
A
R
--
Y
E
S
N
GIPK
D
R
-------
V
L
I
M
I
A
A
T
W
E
G
I
K
A
A
K
L
L
Q
-
K
E
G
I
N
C
N
L
T
L
I
F
D
K
A
Q
A
K
A
C
A
E
A
G
V
Y
-----------------
L
V
S
P
F
V
G
R
I
T
D
--------------
W
---------
Q
M
Q
Q
N
NLKTFPAIAD
D
----------
D
--
G
V
N
S
V
K
A
I
Y
K
L
Y
K
S
H
------------
G
F
-
K
T
I
V
M
G
A
S
--
F
R
N
V
E
Q
V
I
-----
A
L
A
G
C
D
A
L
-
T
I
S
P
V
L
L
E
E
L
K
N
R
D
----------------------
84
PsiBlast_CBE
65.11
31%
-111
- C3 -
3TNO
1
?
B:
[111-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
----
L
--------
D
V
---------
I
-
E
G
K
V
S
S
E
V
DAR
V
S
---
F
N
S
A
T
T
I
D
Y
A
K
R
I
I
A
R
Y
--
E
-------
S
N
GIPKDR-
V
L
I
K
I
A
A
T
W
E
G
I
K
A
A
K
L
L
Q
-
K
E
G
I
N
C
N
L
T
L
I
F
D
K
A
Q
A
K
A
C
A
E
A
G
V
Y
-----------------
L
V
S
P
F
V
G
R
I
T
D
W
Q
M
Q
Q
N
NLKTFPAI
A
---------
D
--------------
D
----------
D
--
G
V
N
S
V
K
A
I
Y
K
L
Y
K
S
H
------------
G
F
-
K
T
I
V
M
G
A
S
--
F
R
N
V
E
Q
V
-----
I
A
L
A
G
C
D
A
L
-
T
I
S
P
V
L
L
E
E
L
--------------------------
17
PsiBlast_PDB
64.46
30%
-114
- C3 -
3TKF
3
?
A:
[111-290]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
----
L
--------
D
V
---------
I
-
E
G
K
V
S
S
E
V
DAR
V
S
---
F
N
S
A
T
T
I
D
Y
A
K
R
I
I
A
R
Y
--
E
-------
S
N
GIPKDR-
V
L
I
M
I
A
A
T
W
E
G
I
K
A
A
K
L
L
Q
-
K
E
G
I
N
C
N
L
T
L
I
F
D
K
A
Q
A
K
A
C
A
E
A
G
V
Y
-----------------
L
V
S
P
F
V
G
R
I
T
D
W
Q
M
Q
Q
N
NLKTFPAI
A
---------
D
--------------
D
----------
D
--
G
V
N
S
V
K
A
I
Y
K
L
Y
K
S
H
------------
G
F
-
K
T
I
V
M
G
A
S
--
F
R
N
V
E
Q
V
-----
I
A
L
A
G
C
D
A
L
-
T
I
S
P
V
L
L
E
E
L
--------------------------
85
PsiBlast_CBE
64.43
31%
-112
- C3 -
3TK7
1
?
B:
[111-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
----
L
--------
D
V
---------
I
-
E
G
K
V
S
S
E
V
DAR
V
S
---
F
N
S
A
T
T
I
D
Y
A
K
R
I
I
A
R
Y
--
E
-------
S
N
GIPKDR-
V
L
I
K
I
A
A
T
W
E
G
I
K
A
A
K
L
L
Q
-
K
E
G
I
N
C
N
L
T
L
I
F
D
K
A
Q
A
K
A
C
A
E
A
G
V
Y
-----------------
L
V
S
P
F
V
G
R
I
T
D
W
Q
M
Q
Q
N
NLKTFPAI
A
---------
D
--------------
D
----------
D
--
G
V
N
S
V
K
A
I
Y
K
L
Y
K
S
H
------------
G
F
-
K
T
I
V
M
G
A
S
--
F
R
N
V
E
Q
V
-----
I
A
L
A
G
C
D
A
L
-
T
I
S
P
V
L
L
E
E
L
--------------------------
16
PsiBlast_PDB
64.00
30%
-113
- C3 -
3TE9
1
?
A:
[111-290]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
----
L
--------
D
V
---------
I
-
E
G
K
V
S
S
E
V
DAR
V
S
---
F
N
S
A
T
T
I
D
Y
A
K
R
I
I
A
R
Y
--
E
-------
S
N
GIPKDR-
V
L
I
M
I
A
A
T
W
E
G
I
K
A
A
K
L
L
Q
-
K
E
G
I
N
C
N
L
T
L
I
F
D
K
A
Q
A
K
A
C
A
E
A
G
V
Y
-----------------
L
V
S
P
F
V
G
R
I
T
D
W
Q
M
Q
Q
NNLKTFPAI
A
---------
D
--------------
D
----------
D
--
G
V
N
S
V
K
A
I
Y
K
L
Y
K
S
H
------------
G
F
-
K
T
I
V
M
G
A
S
--
F
R
N
V
E
Q
V
-----
I
A
L
A
G
C
D
A
L
-
T
I
S
P
V
L
L
E
E
L
--------------------------
10
PsiBlast_PDB
63.93
33%
-105
- C3 -
3HJZ
11
TAL_PROM9
A:
[87-262]
--------------------------------------------------------------------------------------------------------------------------------
K
---------------------------------
E
I
----
L
--------
K
I
---------
I
-
S
G
R
V
S
T
E
V
DAR
L
S
---
F
D
T
E
A
T
V
K
K
A
-
R
K
L
I
N
L
--
Y
-------
K
N
F
GIEKER
I
L
I
K
I
A
A
T
W
E
G
I
K
A
A
E
I
L
E
-
K
E
G
I
K
C
N
L
T
L
L
F
N
F
C
Q
A
V
T
C
A
N
A
N
I
T
-----------------
L
I
S
P
F
V
G
R
I
L
D
W
H
K
A
K
TGKTSF---
I
---------
G
--------------
A
----------
E
D
P
G
V
I
S
V
T
Q
I
Y
K
Y
F
K
E
K
------------
G
F
-
K
T
E
V
M
G
A
S
--
F
R
N
L
D
E
I
K
E
---
L
--
A
G
C
D
L
L
-
T
I
A
----
P
K
F
L
E
E
L
K
R
E
K
G
V
----------------
92
HHSearch
53.89
31%
-83
- C3 -
3CLM
12
TAL_NEIG1
A:
[13-298]
Q
Q
I
W
L
D
N
L
S
R
S
L
V
Q
S
G
E
L
A
Q
M
L
K
Q
G
-
V
C
G
V
T
S
N
P
A
I
F
Q
K
A
---------
F
A
--------------------
G
DAL--
Y
A
--------------------
D
E
V
A
A
L
K
R
QNLS
P
K
Q
R
Y
E
T
M
A
V
A
D
----
V
R
---------------------------------
A
A
----
C
--------
D
V
C
L
A
E
H
E
S
T
G
G
K
T
G
F
V
S
L
E
V
---
S
P
ELA
K
D
A
Q
G
T
V
E
E
A
-
R
R
L
H
A
A
I
A
R
-------
K
N
-------
A
M
I
K
V
P
A
T
D
A
G
I
D
A
L
E
T
L
V
-
S
D
G
I
S
V
N
L
T
L
L
F
S
R
A
Q
T
L
K
A
Y
A
A
Y
A
R
G
I
A
K
R
L
A
A
GQSVAH
I
Q
V
V
A
S
F
F
I
S
R
V
D
S
--------------
A
---------
L
--------------
D
ATLPDRLKGK
T
--
A
I
A
L
A
K
A
A
Y
Q
D
W
E
Q
Y
F
T
A
P
E
F
A
A
L
E
A
Q
G
A
N
R
V
Q
L
L
W
A
S
TG
V
K
N
P
A
Y
P
D
T
L
Y
V
D
S
L
I
G
V
H
T
V
N
T
V
P
D
A
T
L
K
A
F
I
D
H
G
----------------------