@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0644: (2016-03-17 )
LILFYFLLIIGKFTFAYFQIFKDPNFLALGMDLLFIVLLLGLIHLFAPVRSHIYWYAGMSLFIGILMLVCVLYARFYNEVPTYHSFSLIGEVGVVKNSATSLLSGTDWLYILDIILLPFILYFNIKKGHEFPSFRLTSRVYGVSFISTLLILSGFTYFMMQQNIISDSKRAKRMGIFTFNISTALTGADHVKAADITAKNVNDIKGVSVKSNPDYFGAAKGKNLIIVQLESFQRNLTNVKINGQSITPTLDGLQNETMYSNQFFQTVSKSNTADAEWSVYTSTFPSGYYTNTQTYGDRVIPSMPRLLGKNDYKTATFHTNDASFYNRDEFYPAVGFDKFYDRKFFGDEDVIGFSPSDEVLYNKAFPILEEQYKNNQKFYAQLISVSSHMPFDIPKDKQEIDLPSDLKDTELGNYFEAVHYADKQLGEFIQKLKDSGIWDDSVVVFYGDHHIIKTDQLPEEQKKYVNRSTQLKAEPADDYRIPFFLHYPGMENPGEIKNVGGEIDIMPTVMNLLGIKTGDQIMFGTDILNSSNNYVPERYTMPEGSYFTNSYMYQPDESFETGAATNYDGTNKELSSDVKKRFDASRKLLQYSDSYVNNLPLRNEDK
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210--.........220.......230--...-......-240----------------.......250.---....--.---.260.-...-...270.......280..--...------..290...------.------...300......-.310......-----..320..---..----------..------.330--------------..-.......340.------------------------------.-.------.-.----------..-----350----------.-----------.-.......360..-----------.....370...--....380..----.....390....------.-..-------------400--.----------.-------------------.-...-..410.......420.......430.......440.......450-.......---------460-----------------------.----------...---------------------------...-470.......480.......490.-......-.500.........510.......-520.......530-.---------.-------------------------------.-.....540------.---------........550...------....560---......-----.570..----.....580.......590---------.........600....--------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
L
I
L
F
Y
F
L
L
I
I
G
K
F
T
F
A
Y
F
Q
I
FKDP
N
F
L
A
L
G
M
D
L
L
F
I
V
L
L
L
G
L
I
H
L
F
A
P
V
R
S
H
I
Y
W
YA
G
M
S
L
F
I
G
I
L
M
L
V
C
V
L
Y
A
R
F
Y
NEVPTYH
S
F
S
L
I
GEVGVVKNS
A
T
S
LLSGT
D
W
L
Y
I
L
D
I
I
L
L
P
F
I
L
Y
FNIKKGHEFPS
F
R
L
T
S
R
V
Y
G
V
S
F
I
S
T
L
L
I
L
S
G
F
T
Y
F
M
M
Q
Q
N
IIS
D
S
K
R
A
K
R
M
G
I
F
T
F
NISTALTGADH
V
K
AADITAKNVNDIK
G
V
SVK----SNPDYFGAAKGK
N
L
I
I
V
Q
L
E
----
S
F
Q-RNL
T
N
V
-
K
IN----------------GQSITPTLDGL---QNET--M---Y
S
N
Q
F
-
F
Q
T
-VSKSNTADA
E
W
S
V
Y
T
S
TF--PS
G
------
Y
Y
TNTQTY------G------DRV
I
P
S
M
P
R
L
LG-KND-Y
K
T
A
T
F
-----HTNDASF---Y
N
----------
R
D
------EF----------------YP-AVG
F
D
K
F
YDRK------------------------------F-F------G-D----------ED-----V------------I-----------G-FSPSD
E
V
L
YNKA-----------F
P
I
L
E
E
Q
YKN
N
--
Q
K
F
Y
A
Q
L
I
S
----VSSHMPFDIPKD------
K
-
Q
E-------------ID---L----------P-------------------S-DLK-D
T
E
L
G
N
Y
F
E
A
V
H
Y
A
D
K
Q
L
G
E
F
I
Q
K
L
K
DSGIWDD
S
V
V
V
F
YGD
H
H
I
I
-KTDQL
P
E
---------
E
Q
K
-----------------------
K
----------YVN---------------------------RST-QLKAEPADDY
R
I
P
F
F
L
HYPGME-N-PG
E
I
K
N-VG--GE
I
D
I
M
P
T
V
M
N
L
LGIKTG
D
-
Q
I
M
F
G
T
D
ILNSS--N---------N-------------------------------Y-VPERYT--------M---------PEGSYFTNSYMYQP------DESFETG---AATNYD-----GT
N
K
E
L
----
S
S
D
V
K
K
R
F
D
A
S
R
K
L
L
Q
-----------
Y
S
D
S
Y
VNNLPLRNEDK--------------------------
21
PsiBlast_CBE
99.76
100%
-70
- C2 -
4UOP
6
?
B:
[31-439]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
I
T
A
K
N
V
N
D
I
K
G
V
S
V
K
----
S
N
P
D
Y
F
G
A
A
K
G
K
N
L
I
I
V
Q
L
E
----
S
F
Q
-
R
N
L
T
N
V
-
K
I
N
----------------
G
Q
S
I
T
P
T
L
D
G
L
---
Q
N
E
T
--
M
---
Y
S
N
Q
F
-
F
Q
T
-
V
S
K
S
N
T
A
D
A
E
W
S
V
Y
T
S
T
F
--
P
S
G
------
Y
Y
T
N
T
Q
T
Y
------
G
------
D
R
V
I
P
S
M
P
R
L
L
G
-
K
N
D
-
Y
K
T
A
T
F
-----
H
T
N
D
A
S
F
---
Y
N
----------
R
D
------
E
F
----------------
Y
P
-
A
V
G
F
D
K
F
Y
D
R
K
------------------------------
F
-
F
------
G
-
D
----------
E
D
-----
V
------------
I
-----------
G
-
F
S
P
S
D
E
V
L
Y
N
K
A
-----------
F
P
I
L
E
E
Q
Y
K
N
N
--
Q
K
F
Y
A
Q
L
I
S
----
V
S
S
H
M
P
F
D
I
P
K
D
------
K
-
Q
E
-------------
I
D
---
L
----------
P
-------------------
S
-
D
L
K
-
D
T
E
L
G
N
Y
F
E
A
V
H
Y
A
D
K
Q
L
G
E
F
I
Q
K
L
K
D
S
G
I
W
D
D
S
V
V
V
F
Y
G
D
H
H
I
I
-
K
T
D
Q
L
P
E
---------
E
Q
K
-----------------------
K
----------
Y
V
N
---------------------------
R
S
T
-
Q
L
K
A
E
P
A
D
D
Y
R
I
P
F
F
L
H
Y
P
G
M
E
-
N
-
P
G
E
I
K
N
-
V
G
--
G
E
I
D
I
M
P
T
V
M
N
L
L
G
I
K
T
G
D
-
Q
I
M
F
G
T
D
I
L
N
S
S
--
N
---------
N
-------------------------------
Y
-
V
P
E
R
Y
T
--------
M
---------
P
E
G
S
Y
F
T
N
S
Y
M
Y
Q
P
------
D
E
S
F
E
T
G
---
A
A
T
N
Y
D
-----
G
T
N
K
E
L
----
S
S
D
V
K
K
R
F
D
A
S
R
K
L
L
Q
-----------
Y
S
D
S
Y
V
N
N
L
P
L
R
N
-----------------------------
1
PsiBlast_PDB
98.93
100%
-69
- C2 -
4UOP
2
?
A:
[32-439]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
T
A
K
N
V
N
D
I
K
G
V
S
V
K
----
S
N
P
D
Y
F
G
A
A
K
G
K
N
L
I
I
V
Q
L
E
----
S
F
Q
-
R
N
L
T
N
V
-
K
I
N
----------------
G
Q
S
I
T
P
T
L
D
G
L
---
Q
N
E
T
--
M
---
Y
S
N
Q
F
-
F
Q
T
-
V
S
K
S
N
T
A
D
A
E
W
S
V
Y
T
S
T
F
--
P
S
G
------
Y
Y
T
N
T
Q
T
Y
------
G
------
D
R
V
I
P
S
M
P
R
L
L
G
-
K
N
D
-
Y
K
T
A
T
F
-----
H
T
N
D
A
S
F
---
Y
N
----------
R
D
------
E
F
----------------
Y
P
-
A
V
G
F
D
K
F
Y
D
R
K
------------------------------
F
-
F
------
G
-
D
----------
E
D
-----
V
------------
I
-----------
G
-
F
S
P
S
D
E
V
L
Y
N
K
A
-----------
F
P
I
L
E
E
Q
Y
K
N
N
--
Q
K
F
Y
A
Q
L
I
S
----
V
S
S
H
M
P
F
D
I
P
K
D
------
K
-
Q
E
-------------
I
D
---
L
----------
P
-------------------
S
-
D
L
K
-
D
T
E
L
G
N
Y
F
E
A
V
H
Y
A
D
K
Q
L
G
E
F
I
Q
K
L
K
D
S
G
I
W
D
D
S
V
V
V
F
Y
G
D
H
H
I
I
-
K
T
D
Q
L
P
E
---------
E
Q
K
-----------------------
K
----------
Y
V
N
---------------------------
R
S
T
-
Q
L
K
A
E
P
A
D
D
Y
R
I
P
F
F
L
H
Y
P
G
M
E
-
N
-
P
G
E
I
K
N
-
V
G
--
G
E
I
D
I
M
P
T
V
M
N
L
L
G
I
K
T
G
D
-
Q
I
M
F
G
T
D
I
L
N
S
S
--
N
---------
N
-------------------------------
Y
-
V
P
E
R
Y
T
--------
M
---------
P
E
G
S
Y
F
T
N
S
Y
M
Y
Q
P
------
D
E
S
F
E
T
G
---
A
A
T
N
Y
D
-----
G
T
N
K
E
L
----
S
S
D
V
K
K
R
F
D
A
S
R
K
L
L
Q
-----------
Y
S
D
S
Y
V
N
N
L
P
L
R
N
-----------------------------
3
PsiBlast_PDB
73.27
31%
-44
- C2 -
2W5Q
2
LTAS_STAAW
A:
[1-397]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
D
D
L
T
K
V
L
N
Y
T
K
Q
R
Q
T
E
----
P
N
P
E
Y
Y
G
V
A
K
K
K
N
I
I
K
I
H
L
E
----
S
F
Q
-
T
F
L
I
N
K
-
K
V
N
----------------
G
K
E
V
T
P
F
L
N
K
L
S
S
G
K
E
Q
F
--
T
---
Y
F
P
N
F
-
F
H
Q
-
T
G
Q
G
K
T
S
D
S
E
F
T
M
D
N
S
L
Y
GL
P
Q
G
------
S
A
F
S
L
K
--------
G
------
D
N
T
Y
Q
S
L
P
A
I
L
D
Q
K
Q
G
-
Y
K
S
D
V
M
-----
H
G
D
Y
K
T
F
---
W
N
----------
R
D
------
Q
V
----------------
Y
K
-
H
F
G
I
D
K
F
Y
D
A
T
------------------------------
Y
-
Y
DM----
S
-
D
----------
K
N
-----
V
------------
V
-----------
N
-
L
G
L
K
D
K
I
F
F
K
D
S
--------------
A
N
Y
Q
A
K
M
K
--
S
P
F
Y
S
H
L
I
T
----
L
T
N
H
Y
P
F
T
L
D
E
K
------
D
-
A
T
-------------
I
E
--------------
K
-------------------
S
-
N
T
G
-
D
A
T
V
D
G
Y
I
Q
T
A
R
Y
L
D
E
A
L
E
E
Y
I
N
D
L
K
K
K
G
L
Y
D
N
S
V
I
M
I
Y
G
D
H
Y
G
I
-
S
E
N
H
N
N
A
---------
M
E
K
-----------------------
L
----------
L
G
E
---------------------------
K
I
T
-
P
--
A
K
F
T
D
L
N
R
T
G
F
W
I
K
I
P
G
K
S
----
G
G
I
N
N
E
Y
A
--
G
Q
V
D
V
M
P
T
I
L
H
L
A
G
I
D
T
K
N
-
Y
L
M
F
G
T
D
L
F
S
K
G
--
H
---------
N
-------------------------------
Q
V
V
P
F
R
---------------------
N
G
D
F
I
T
K
D
Y
K
Y
V
-----------------
N
G
K
I
Y
S
-----
N
K
N
N
E
L
ITTQ
P
A
D
F
E
K
N
K
K
Q
V
E
K
D
L
E
-----------
M
S
D
N
V
L
N
-----------------------------------
5
PsiBlast_PDB
73.19
31%
-44
- C2 -
2W5T
3
LTAS_STAAW
A:
[1-397]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
D
D
L
T
K
V
L
N
Y
T
K
Q
R
Q
T
E
----
P
N
P
E
Y
Y
G
V
A
K
K
K
N
I
I
K
I
H
L
E
----
S
F
Q
-
T
F
L
I
N
K
-
K
V
N
----------------
G
K
E
V
T
P
F
L
N
K
L
S
S
G
K
E
Q
F
--
T
---
Y
F
P
N
F
-
F
H
Q
-
T
G
Q
G
K
T
S
D
S
E
F
T
M
D
N
S
L
Y
GL
P
Q
G
------
S
A
F
S
L
K
--------
G
------
D
N
T
Y
Q
S
L
P
A
I
L
D
Q
K
Q
G
-
Y
K
S
D
V
M
-----
H
G
D
Y
K
T
F
---
W
N
----------
R
D
------
Q
V
----------------
Y
K
-
H
F
G
I
D
K
F
Y
D
A
T
------------------------------
Y
-
Y
DM----
S
-
D
----------
K
N
-----
V
------------
V
-----------
N
-
L
G
L
K
D
K
I
F
F
K
D
S
--------------
A
N
Y
Q
A
K
M
K
--
S
P
F
Y
S
H
L
I
T
----
L
T
N
H
Y
P
F
T
L
D
E
K
------
D
-
A
T
-------------
I
E
--------------
K
-------------------
S
-
N
T
G
-
D
A
T
V
D
G
Y
I
Q
T
A
R
Y
L
D
E
A
L
E
E
Y
I
N
D
L
K
K
K
G
L
Y
D
N
S
V
I
M
I
Y
G
D
H
Y
G
I
-
S
E
N
H
N
N
A
---------
M
E
K
-----------------------
L
----------
L
G
E
---------------------------
K
I
T
-
P
--
A
K
F
T
D
L
N
R
T
G
F
W
I
K
I
P
G
K
S
----
G
G
I
N
N
E
Y
A
--
G
Q
V
D
V
M
P
T
I
L
H
L
A
G
I
D
T
K
N
-
Y
L
M
F
G
T
D
L
F
S
K
G
--
H
---------
N
-------------------------------
Q
V
V
P
F
R
---------------------
N
G
D
F
I
T
K
D
Y
K
Y
V
-----------------
N
G
K
I
Y
S
-----
N
K
N
N
E
L
ITTQ
P
A
D
F
E
K
N
K
K
Q
V
E
K
D
L
E
-----------
M
S
D
N
V
L
N
-----------------------------------
4
PsiBlast_PDB
72.95
31%
-46
- C2 -
2W5S
3
LTAS_STAAW
A:
[1-397]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
D
D
L
T
K
V
L
N
Y
T
K
Q
R
Q
T
E
----
P
N
P
E
Y
Y
G
V
A
K
K
K
N
I
I
K
I
H
L
E
----
S
F
Q
-
T
F
L
I
N
K
-
K
V
N
----------------
G
K
E
V
T
P
F
L
N
K
L
S
SG
K
E
Q
F
--
T
---
Y
F
P
N
F
-
F
H
Q
-
T
G
Q
G
K
T
S
D
S
E
F
T
M
D
N
S
L
Y
GL
P
Q
G
------
S
A
F
S
L
K
--------
G
------
D
N
T
Y
Q
S
L
P
A
I
L
D
Q
K
Q
G
-
Y
K
S
D
V
M
-----
H
G
D
Y
K
T
F
---
W
N
----------
R
D
------
Q
V
----------------
Y
K
-
H
F
G
I
D
K
F
Y
D
A
T
------------------------------
Y
-
Y
DM----
S
-
D
----------
K
N
-----
V
------------
V
-----------
N
-
L
G
L
K
D
K
I
F
F
K
D
S
--------------
A
N
Y
Q
A
K
M
K
--
S
P
F
Y
S
H
L
I
T
----
L
T
N
H
Y
P
F
T
L
D
E
K
------
D
-
A
T
-------------
I
E
--------------
K
-------------------
S
-
N
T
G
-
D
A
T
V
D
G
Y
I
Q
T
A
R
Y
L
D
E
A
L
E
E
Y
I
N
D
L
K
K
K
G
L
Y
D
N
S
V
I
M
I
Y
G
D
H
Y
G
I
-
S
E
N
H
N
N
A
---------
M
E
K
-----------------------
L
----------
L
G
E
---------------------------
K
I
T
-
P
--
A
K
F
T
D
L
N
R
T
G
F
W
I
K
I
P
G
K
S
----
G
G
I
N
N
E
Y
A
--
G
Q
V
D
V
M
P
T
I
L
H
L
A
G
I
D
T
K
N
-
Y
L
M
F
G
T
D
L
F
S
K
G
--
H
---------
N
-------------------------------
Q
V
V
P
F
R
---------------------
N
G
D
F
I
T
K
D
Y
K
Y
V
-----------------
N
G
K
I
Y
S
-----
N
K
N
N
E
L
ITTQ
P
A
D
F
E
K
N
K
K
Q
V
E
K
D
L
E
-----------
M
S
D
N
V
L
N
-----------------------------------
47
Fugue
72.89
27%
-44
- C2 -
2W5Q
2
LTAS_STAAW
A:
[1-424]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
D
D
L
T
K
V
L
N
Y
--------------------------
T
K
Q
R
Q
T
E
----
P
N
P
E
Y
Y
G
V
A
K
K
K
N
I
I
K
I
H
L
E
----
S
F
Q
-
T
F
L
I
N
K
-
K
V
N
----------------
G
K
E
V
T
P
F
L
N
K
L
S
S
G
K
E
Q
F
--
T
---
Y
F
P
N
F
-
F
H
Q
-
T
G
Q
G
K
T
S
D
S
E
F
T
M
D
N
S
L
Y
--
G
L
P
------
Q
G
S
A
F
S
L
K
------
G
------
D
N
T
Y
Q
S
L
P
A
I
L
D
-
Q
K
Q
G
Y
K
S
D
V
M
-----
H
G
D
Y
K
T
F
---
W
N
----------
R
D
------
Q
V
----------------
Y
K
-
H
F
G
I
D
K
F
Y
D
A
T
------------------------------
Y
-
Y
DM----
S
-
D
----------
K
N
-----
V
------------
V
-----------
N
-
L
G
L
K
D
K
I
F
F
K
D
S
-----------
A
N
Y
Q
A
K
M
---
K
--
S
P
F
Y
S
H
L
I
T
----
L
T
N
H
Y
P
F
T
L
D
E
K
------
D
-
A
T
-------------
I
E
--------------
K
-------------------
S
-
N
T
G
-
D
A
T
V
D
G
Y
I
Q
T
A
R
Y
L
D
E
A
L
E
E
Y
I
N
D
L
K
K
K
G
L
Y
D
N
S
V
I
M
I
Y
G
D
H
Y
G
I
-
S
E
N
H
N
N
A
---------
M
E
K
-----------------------
L
----------
L
G
E
---------------------------
K
I
T
-
P
A
K
F
T
D
L
N
--
R
T
G
F
W
I
K
I
P
G
K
--
S
-
G
G
I
N
N
E
-
Y
A
--
G
Q
V
D
V
M
P
T
I
L
H
L
A
G
I
D
T
K
N
-
Y
L
M
F
G
T
D
L
F
S
K
G
--
H
---------
N
-------------------------------
Q
----
V
V
P
--------
F
---------
R
N
G
D
F
I
T
K
D
Y
K
Y
V
N
------
G
K
I
Y
S
N
K
NNE
L
I
T
T
Q
P
-----
A
D
F
E
K
N
----
K
K
Q
V
E
K
D
L
E
M
S
D
N
V
L
N
G
DLFRFYKNPD
F
K
K
V
N
P
S
K
Y
K
Y
E
T
G
P
K
--------------------------
23
HHSearch
72.36
30%
-51
- C2 -
2W5Q
2
LTAS_STAAW
A:
[21-405]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
Y
Y
G
V
A
K
K
K
N
I
I
K
I
H
L
E
----
S
F
Q
-
T
F
L
I
N
K
-
K
V
N
----------------
G
K
E
V
T
P
F
L
N
K
L
---
S
S
G
K
--
E
Q
F
T
Y
F
P
N
F
-
F
H
Q
-
T
G
Q
G
K
T
S
D
S
E
F
T
M
D
N
S
L
Y
--
G
L
P
------
Q
G
S
A
F
S
L
K
------
G
------
D
N
T
Y
Q
S
L
P
A
I
L
D
Q
K
Q
G
-
Y
K
S
D
V
M
-----
H
G
D
Y
K
T
F
---
W
N
----------
R
D
------
Q
V
----------------
Y
K
-
H
F
G
I
D
K
F
Y
D
A
T
------------------------------
Y
-
Y
------
D
-
M
SD--------
K
N
-----
V
------------
V
-----------
N
-
L
G
L
K
D
K
I
F
F
K
D
S
-----------
A
N
Y
Q
A
K
M
---
K
--
S
P
F
Y
S
H
L
I
T
----
L
T
N
H
Y
P
F
T
L
D
E
K
------
D
-
A
T
-------------
I
E
--------------
K
-------------------
S
-
N
T
G
-
D
A
T
V
D
G
Y
I
Q
T
A
R
Y
L
D
E
A
L
E
E
Y
I
N
D
L
K
K
K
G
L
Y
D
N
S
V
I
M
I
Y
G
D
H
Y
G
I
-
S
E
N
H
N
N
A
---------
M
E
K
-----------------------
L
----------
L
G
----------------------------
E
K
I
T
P
A
K
F
T
-
D
L
-
N
R
T
G
F
W
I
K
I
P
G
K
S
---
G
G
I
N
N
E
-
Y
A
--
G
Q
V
D
V
M
P
T
I
L
H
L
A
G
I
D
T
K
N
-
Y
L
M
F
G
T
D
L
F
S
K
G
H-
N
---------
Q
-------------------------------
V
-----
V
P
--------
F
---------
R
N
G
D
F
I
T
K
D
Y
K
Y
V
N
------
G
K
I
Y
S
N
K
---
N
N
E
L
I
T
-------
T
--
Q
----
P
A
D
F
E
K
N
K
K
Q
V
E
K
D
L
E
-----------
M
S
D
N
V
L
N
G
D
L
F
R
F
Y
K
---------------------------
22
HHSearch
71.43
30%
-47
- C2 -
2W8D
3
LTAS2_BACSU
A:
[4-405]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
D
V
T
E
V
E
N
Y
M
K
A
N
Y
D
V
P
N
N
V
Y
F
G
K
A
E
G
K
N
V
I
Y
V
S
L
E
----
S
L
Q
-
S
F
I
I
D
Y
-
K
I
D
----------------
G
K
E
V
T
P
F
L
N
K
L
---
A
H
D
N
E
T
F
---
Y
F
D
N
F
-
F
H
Q
-
T
G
Q
G
K
T
S
D
A
E
F
M
M
E
N
S
L
Y
--
P
L
A
------
Q
G
S
V
F
V
N
K
------
A
------
Q
N
T
L
Q
S
V
P
A
I
L
K
-
S
K
N
-
Y
T
S
A
T
F
-----
H
G
N
T
Q
T
F
---
W
N
----------
R
N
------
E
M
----------------
Y
K
-
A
E
G
I
D
K
F
F
D
S
A
------------------------------
Y
-
Y
------
D
-
M
NE--------
E
N
-----
T
------------
K
-----------
N
-
Y
G
M
K
D
K
P
F
F
K
E
S
-----------
M
P
L
L
E
S
L
---
P
--
Q
P
F
Y
T
K
F
I
T
----
L
S
N
H
F
P
F
G
M
D
E
G
------
D
-
T
D
-------------
F
P
--------------
A
-------------------
G
-
D
F
G
-
D
S
V
V
D
N
Y
F
Q
S
A
H
Y
L
D
Q
S
I
E
Q
F
F
N
D
L
K
K
D
G
L
Y
D
K
S
I
I
V
M
Y
G
D
H
Y
G
I
-
S
E
N
H
N
K
A
---------
M
A
K
-----------------------
V
----------
L
G
----------------------------
K
D
E
-
I
T
D
Y
D
N
A
Q
L
Q
R
V
P
L
F
I
H
A
A
G
V
K
---
G
E
K
V
H
K
-
Y
A
--
G
D
V
D
V
A
P
T
I
L
H
L
L
G
V
D
T
K
D
-
Y
L
M
S
G
S
D
I
L
S
K
E
--
H
---------
R
-------------------------------
E
----
V
I
P
--------
F
---------
R
N
G
D
F
I
S
P
K
Y
T
K
I
S
------
G
K
Y
Y
D
T
K
---
T
G
K
E
L
---------
D
-
E
----
S
E
V
D
K
S
E
D
S
L
V
K
K
E
L
E
-----------
M
S
D
K
I
I
N
G
D
L
L
R
F
Y
E
---------------------------
2
PsiBlast_PDB
71.30
31%
-58
- C2 -
2W8D
3
LTAS2_BACSU
A:
[25-396]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
F
G
K
A
E
G
K
N
V
I
Y
V
S
L
E
----
S
L
Q
-
S
F
I
I
D
Y
-
K
I
D
----------------
G
K
E
V
T
P
F
L
N
K
L
A
H
-
D
N
E
T
--
F
---
Y
F
D
N
F
-
F
H
Q
-
T
G
Q
G
K
T
S
D
A
E
F
M
M
E
N
S
L
Y
--
P
L
A
------
Q
G
S
V
F
V
N
K
------
A
------
Q
N
T
L
Q
S
V
P
A
I
L
K
-
S
K
N
-
Y
T
S
A
T
F
-----
H
G
N
T
Q
T
F
---
W
N
----------
R
N
------
E
M
----------------
Y
K
-
A
E
G
I
D
K
F
F
D
S
A
------------------------------
Y
-
Y
DM----
N
-
E
----------
E
N
-----
T
------------
K
-----------
N
-
Y
G
M
K
D
K
P
F
F
K
E
S
-----------
M
P
L
L
E
S
L
---
P
--
Q
P
F
Y
T
K
F
I
T
----
L
S
N
H
F
P
F
--
G
M
D
------
E
-
G
D
-------------
T
D
---
F
----------
P
-------------------
A
G
D
F
G
-
D
S
V
V
D
N
Y
F
Q
S
A
H
Y
L
D
Q
S
I
E
Q
F
F
N
D
L
K
K
D
G
L
Y
D
K
S
I
I
V
M
Y
G
D
H
Y
G
I
--
S
E
N
H
N
K
---------
A
M
A
-----------------------
K
----------
V
L
G
---------------------------
K
D
E
-
I
T
D
Y
D
N
A
Q
L
Q
R
V
P
L
F
I
H
A
A
G
V
K
-
G
-
E
-
K
V
H
K
-
Y
A
--
G
D
V
D
V
A
P
T
I
L
H
L
L
G
V
D
T
K
D
-
Y
L
M
S
G
S
D
I
L
S
K
E
--
H
REVIPFRN
G
D
-------------------------------
F
-
I
S
P
K
Y
T
--------
K
---------
I
S
G
K
Y
Y
D
T
K
T
G
K
E
L
------
D
E
S
------------------
E
V
D
K
S
E
----
D
S
L
V
K
K
E
L
E
M
S
D
K
I
I
------------------------------------------------------
7
PsiBlast_PDB
70.38
32%
-51
- C2 -
4UOR
2
?
A:
[33-426]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
D
V
T
-
E
V
L
N
Y
T
K
S
K
Y
A
A
----
P
N
P
E
Y
F
G
K
A
K
G
K
N
V
I
Y
I
H
L
E
----
S
F
Q
-
Q
F
L
V
N
Y
-
K
L
N
----------------
G
E
E
V
T
P
F
I
N
S
F
F
K
D
Q
N
T
L
--
S
---
F
T
N
-
F
-
F
H
Q
-
T
G
Q
G
K
T
A
D
S
E
M
L
L
E
N
S
L
Y
GL
P
Q
G
--------
S
A
F
T
T
K
------
G
------
Q
N
T
Y
E
S
A
S
A
I
L
G
-
Q
Q
G
-
Y
T
S
A
V
F
-----
H
G
N
Y
K
S
F
---
W
N
----------
R
D
------
E
I
----------------
Y
K
-
Q
F
G
Y
D
N
F
F
D
A
S
------------------------------
Y
-
Y
--------------------
D
-----
M
------------
N
-----------
E
-
A
D
V
S
N
Y
G
L
K
D
K
P
-----------
F
F
K
E
S
E
E
Y
L
S
S
LQ
Q
P
F
Y
T
K
F
I
T
----
L
T
N
H
F
P
Y
P
I
D
E
K
------
D
-
A
S
-------------
I
----
A
----------
P
-------------------
A
-
T
T
G
-
D
S
S
V
D
T
Y
F
Q
T
A
R
Y
L
D
E
S
V
K
S
F
V
D
Y
L
K
K
S
G
L
Y
D
N
S
V
I
I
M
Y
G
D
H
Y
G
I
--
S
D
N
H
E
E
---------
A
M
T
-----------------------
K
----------
I
L
G
---------------------------
K
D
Y
-
N
T
-
F
E
N
A
Q
A
Q
R
V
P
L
M
I
H
V
P
G
V
Q
-
G
--
G
V
Q
E
Q
-
Y
G
--
G
Q
V
D
L
L
P
T
L
L
H
L
L
G
V
D
N
K
E
-
Y
L
Q
F
G
T
D
L
L
S
K
D
--
H
K
Q
L
V
P
FRN
G
D
-------------------------------
Y
-
I
T
P
T
Y
S
--------
M
---------
I
G
G
----
N
M
Y
N
Q
Q
T
------
G
E
P
I
A
T
E
---
T
K
----------
E
M
K
E
T
----
K
E
K
V
A
K
E
L
E
L
S
D
S
V
L
Q
-----------------------------------------------------
8
PsiBlast_PDB
70.13
32%
-46
- C2 -
2W5R
3
LTAS_STAAW
A:
[1-357]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
D
D
L
T
K
V
L
N
Y
T
K
Q
R
Q
T
E
----
P
N
P
E
Y
Y
G
V
A
K
K
K
N
I
I
K
I
H
L
E
----
S
F
Q
-
T
F
L
I
N
K
-
K
V
N
----------------
G
K
E
V
T
P
F
L
N
K
L
S
S
G
K
E
Q
F
--
T
---
Y
F
P
N
F
-
F
H
Q
-
T
G
Q
G
K
A
S
D
S
E
F
T
M
D
N
S
L
Y
GL
P
Q
G
------
S
A
F
S
L
K
--------
G
------
D
N
T
Y
Q
S
L
P
A
I
L
D
Q
K
Q
G
-
Y
K
S
D
V
M
-----
H
G
D
Y
K
T
F
---
W
N
----------
R
D
------
Q
V
----------------
Y
K
-
H
F
G
I
D
K
F
Y
D
A
T
------------------------------
Y
-
Y
DM----
S
-
D
----------
K
N
-----
V
------------
V
-----------
N
-
L
G
L
K
D
K
I
F
F
K
D
S
--------------
A
N
Y
Q
A
K
M
K
--
S
P
F
Y
S
H
L
I
T
----
L
T
N
H
Y
P
F
T
L
D
E
K
------
D
-
A
T
-------------
I
E
--------------
K
-------------------
S
-
N
T
G
-
D
A
T
V
D
G
Y
I
Q
T
A
R
Y
L
D
E
A
L
E
E
Y
I
N
D
L
K
K
K
G
L
Y
D
N
S
V
I
M
I
Y
G
D
H
Y
G
I
-
S
E
N
H
N
N
A
---------
M
E
K
-----------------------
L
----------
L
G
E
---------------------------
K
I
T
-
P
--
A
K
F
T
D
L
N
R
T
G
F
W
I
K
I
P
G
K
S
----
G
G
I
N
N
E
Y
A
--
G
Q
V
D
V
M
P
T
I
L
H
L
A
G
I
D
T
K
N
-
Y
L
M
F
G
T
D
L
F
S
K
G
--
H
---------
N
-------------------------------
Q
V
V
P
F
R
---------------------
N
G
D
F
I
T
K
D
Y
K
Y
------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
69.27
32%
-49
- C2 -
4UOO
1
?
A:
[36-426]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
-
E
V
L
N
Y
T
K
S
K
Y
A
A
----
P
N
P
E
Y
F
G
K
A
K
G
K
N
V
I
Y
I
H
L
E
----
S
F
Q
-
Q
F
L
V
N
Y
-
K
L
N
----------------
G
E
E
V
T
P
F
I
N
S
F
F
K
D
Q
N
T
L
--
S
---
F
T
N
-
F
-
F
H
Q
-
T
G
Q
G
K
T
A
D
S
E
M
L
L
E
N
S
L
Y
GL
P
Q
G
--------
S
A
F
T
T
K
------
G
------
Q
N
T
Y
E
S
A
S
A
I
L
G
-
Q
Q
G
-
Y
T
S
A
V
F
-----
H
G
N
Y
K
S
F
---
W
N
----------
R
D
------
E
I
----------------
Y
K
-
Q
F
G
Y
D
N
F
F
D
A
S
------------------------------
Y
-
Y
--------------------
D
-----
M
------------
N
-----------
E
-
A
D
V
S
N
Y
G
L
K
D
K
P
-----------
F
F
K
E
S
E
E
Y
L
S
S
LQ
Q
P
F
Y
T
K
F
I
T
----
L
T
N
H
F
P
Y
P
I
D
E
K
------
D
-
A
S
-------------
I
----
A
----------
P
-------------------
A
-
T
T
G
-
D
S
S
V
D
T
Y
F
Q
T
A
R
Y
L
D
E
S
V
K
S
F
V
D
Y
L
K
K
S
G
L
Y
D
N
S
V
I
I
M
Y
G
D
H
Y
G
I
--
S
D
N
H
E
E
---------
A
M
T
-----------------------
K
----------
I
L
G
---------------------------
K
D
Y
-
N
T
-
F
E
N
A
Q
A
Q
R
V
P
L
M
I
H
V
P
G
V
Q
-
G
--
G
V
Q
E
Q
-
Y
G
--
G
Q
V
D
L
L
P
T
L
L
H
L
L
G
V
D
N
K
E
-
Y
L
Q
F
G
T
D
L
L
S
K
D
--
H
K
Q
L
V
P
FRN
G
D
-------------------------------
Y
-
I
T
P
T
Y
S
--------
M
---------
I
G
G
----
N
M
Y
N
Q
Q
T
------
G
E
P
I
A
T
E
---
T
K
----------
E
M
K
E
T
----
K
E
K
V
A
K
E
L
E
L
S
D
S
V
L
Q
-----------------------------------------------------
9
PsiBlast_PDB
61.61
26%
-55
- C2 -
3LXQ
1
?
A:
[76-356]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
N
P
A
T
Y
-
Q
G
K
R
K
N
L
V
I
L
L
Q
E
----
S
L
G
-
A
Q
F
V
G
--
S
L
G
----------------
G
L
P
L
T
P
N
L
D
E
L
---
M
Q
E
G
--
W
---
Q
F
T
Q
M
-
Y
A
T
-
G
T
R
S
V
R
G
---
I
E
A
V
T
T
G
F
--
P
P
S
PSRAVV
K
L
S
K
S
Q
T
----------------
G
F
F
T
I
A
D
L
L
K
-
E
Q
G
-
Y
H
T
Q
F
I
-----
Y
G
G
E
A
N
F
---
D
N
----------
M
K
------
T
F
----------------
F
F
-
G
N
G
F
D
Q
I
V
E
E
K
------------------------------
N
-
Y
------
T
-
N
----------
P
G
-----
F
------------
V
-----------
G
S
W
G
V
S
D
E
D
L
Y
N
K
A
-----------
D
E
E
F
E
R
L
S
K
G
D
--
K
P
F
F
S
L
V
F
T
----
S
S
N
H
S
P
Y
E
Y
P
E
G
------
K
-
I
E
----------------------------------------------------
Q
Y
-
D
S
E
H
M
T
R
N
N
A
V
K
Y
S
D
Y
A
L
G
T
F
F
D
K
A
K
K
S
S
Y
W
D
D
T
I
F
I
V
I
A
D
H
D
A
-------------------------------------------------------------------------------------
R
V
F
-
G
A
N
L
V
P
V
K
H
F
H
I
P
A
L
I
I
G
K
D
I
Q
---
P
R
K
D
D
R
-
I
A
--
N
N
I
D
M
P
P
T
L
L
S
L
I
G
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
60.64
23%
-27
- C2 -
3LXQ
1
?
A:
[81-442]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Q
G
K
R
K
N
L
V
I
L
L
Q
E
----
S
L
G
-
A
Q
F
V
G
S
-
L
G
G
-----------------
L
P
L
T
P
N
L
D
E
L
---
M
Q
E
G
--
W
---
Q
F
T
Q
M
-
Y
A
T
---
G
T
R
S
V
R
G
I
E
A
V
T
T
G
F
P
--
P
S
P
------
S
R
A
V
V
K
L
S
K-----
S
------
Q
T
G
F
F
T
I
A
D
L
L
K
-
E
Q
G
-
Y
H
T
Q
F
I
-----
Y
G
G
E
A
N
F
---
D
N
----------
M
K
------
T
F
----------------
F
F
-
G
N
G
F
D
Q
I
V
E
E
K
------------------------------
N
-
Y
------
T
-
N
P---------
G
F
-----
V
------------
G
-----------
S
-
W
G
V
S
D
E
D
L
Y
N
K
A
-----------
D
E
E
F
E
R
L
S
K
G
D
--
K
P
F
F
S
L
V
F
T
----
S
S
N
H
S
P
Y
E
Y
-
P
E
------
G
-
K
I
-------------
E
--------------------------------------
Q
Y
-
D
S
E
H
M
T
R
N
N
A
V
K
Y
S
D
Y
A
L
G
T
F
F
D
K
A
K
K
S
S
Y
W
D
D
T
I
F
I
V
I
A
D
H
D
A
R
-
V
F
G
A
-------------------------------------------------------------------------------
N
L
----
V
P
-
V
K
H
-
F
H
I
P
A
L
I
I
G
K
D
I
Q
---
P
R
K
D
D
R
-
I
A
--
N
N
I
D
M
P
P
T
L
L
S
L
I
G
V
D
A
K
T
--
P
M
I
G
R
D
L
T
K
P
L
A
R
E
---------
D
-------------------------------
E
-
R
A
M
M
Q
Y
--------
D
---------
K
N
F
G
Y
L
T
R
D
N
L
V
V
L
S
P
GE
K
-
V
S
T
M
E
Y
D
---
F
E
S
Q
--------
T
M
K
-
P
----
L
E
V
D
E
S
V
I
D
R
A
K
A
N
A
L
-----------
F
A
S
K
A
Y
Q
N
N
---------------------------------
49
Fugue
53.93
14%
-17
- C2 -
1E3C
2
ARSA_HUMAN
P:
[1-485]
---------------------
R
P
P
N
I
V
L
I
F
A
D
D
L
-----------------------------------------------
G
Y
G
D
L
G
C
Y
G
H
P
S
S
T
T
P
N
L
D
Q
L
A
A
----------------------
G
G
L
R
F
T
D
F
Y
V
P
V
---
S
L
S
T
P
S
R
A
A
L
L
T
G
--
R
L
P
V
R
M
G
M
Y
P
G
V
L
V
P
S
S
R
G
G
L
P
L
E
E
V
T
V
A
E
V
L
A
--------------------------
A
R
G
Y
L
T
G
M
A
G
K
-------------
W
H
-
L
G
V
G
P
---------------------
E
G
A
F
L
P
P
H
Q
G
F
---
H
R
F
L
--
G
---
I
P
Y
S
H
-
D
Q
G
-
P
C
Q
N
L
T
C
F
P
P
A
T
P
C
D
G
G
C
--
D
Q
G
------
L
V
P
I
P
L
L
A
------
N
------
L
S
V
E
A
Q
P
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
G
L
E
A
R
Y
M
A
F
A
-----------
H
D
L
M
A
D
A
Q
R
E
D
--
R
P
F
F
L
Y
Y
A
S
----
H
H
T
H
Y
P
Q
F
S
G
Q
S
------
F
-
A
------------------------------------------------------
E
-
R
S
G
R
G
P
F
G
D
S
L
M
E
L
D
A
A
V
G
T
L
M
T
A
I
G
D
L
G
L
L
E
E
T
L
V
I
F
T
A
D
N
G
P
E
-
T
M
R
M
S
R
G
---------
G
C
S
-----------------------
G
----------
L
L
R
---------------------------
C
G
K
-
G
T
T
Y
E
G
G
V
--
R
E
P
A
L
A
F
W
P
G
H
I
-
A
-
P
G
V
T
H
E
-
L
A
--
S
S
L
D
L
L
P
T
L
A
A
L
A
G
A
P
L
P
N
-
V
T
L
D
G
F
D
L
S
P
L
L
--
L
---------
G
TGKSPRQSLFFYPSYPDEVRGVFAVRTGKYK
A
-
H
F
F
T
Q
G
--------
S
---------
A
H
S
D
T
T
A
D
P
A
C
H
A
S
------
S
S
L
T
A
H
E
---
P
P
L
L
Y
D
LSKDP
G
E
N
Y
N
L
----
L
G
A
T
P
E
V
L
Q
A
L
K
Q
L
Q
L
-----------
L
K
A
Q
L
D
A
A
V
T
F
G
P
S
Q
V
ARGEDPALQICCHPGCTPRPACCHCP
28
HHSearch
53.28
14%
-31
* C2 *
3B5Q
15
?
A:
[15-415]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
P
N
F
L
I
I
Q
C
D
----
H
L
T
-
Q
R
V
V
G
A
-
Y
G
Q
----------------
T
Q
G
C
T
L
P
I
D
E
V
---
A
S
R
G
--
V
---
I
F
S
N
A
-
Y
V
G
-
C
--
P
L
S
Q
P
S
R
A
A
L
W
S
G
M
M
--
P
H
Q
------
T
N
V
R
S
N
S
S
------
E
PVNTRL
P
E
N
V
P
T
L
G
S
L
F
S
-
E
S
G
-
Y
E
A
V
H
F
-----
G
K
T
H
D
M
G
------------------------------------------
S
-
L
R
G
F
K
H
K
E
P
V
A
------------------------------
K
P
F
------
T
-
D
PE--------
F
P
-----
V
------------
N
-----------
N
-
D
S
F
L
D
V
G
T
C
E
D
A
-----------
V
A
Y
L
S
N
P
--
P
K
--
E
P
F
I
C
I
A
D
F
----
Q
N
P
H
N
I
C
G
F
-
I
G
------
E
N
A
G
V
H
T
D
RPISGPLPE
L
P
---
D
NFDVEDWSNI
P
T
P
V
Q
Y
I
CCSH
R
R
M
T
Q
A
A
HW
N
-
E
E
N
Y
R
H
Y
I
A
A
F
Q
H
Y
T
K
M
V
S
K
Q
V
D
S
V
L
K
A
L
Y
S
T
P
A
G
R
N
T
I
V
V
I
M
A
D
H
G
D
G
-
M
A
S
H
--------------
R
-----------------------
M
----------
V
T
----------------------------
K
H
--
I
S
F
Y
D
E
M
--
T
N
V
P
F
I
F
A
G
P
G
I
K
-
Q
Q
K
K
P
V
D
H
-
L
L
T
Q
P
T
L
D
L
L
P
T
L
C
D
L
A
G
I
A
V
P
A
--
E
K
A
G
I
S
L
A
P
T
L
R
G
E
KQKK-----
S
-------------------------------
H
-
P
Y
V
V
S
E
--------
W
H
S
EYEY
V
T
T
P
G
R
M
V
R
G
P
R
Y
K
Y
T
H
Y
LEGN
G
E
E
L
Y
D
M
K
---
K
D
P
---------------------------------------------------------------------------------------
25
HHSearch
52.76
17%
-26
- C2 -
3ED4
6
?
A:
[27-447]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
P
N
L
V
I
I
M
A
D
----
D
L
G
-
Y
G
D
L
A
T
-
Y
G
H
----------------
Q
I
V
K
T
P
N
I
D
R
L
---
A
Q
E
G
--
V
---
K
F
T
D
Y
-
Y
A
P
-
A
P
--
L
S
S
P
S
R
A
G
L
L
T
G
R
M
--
P
F
R
------
T
G
I
R
S
W
I
P
S
GKDVA
L
------
G
R
N
E
L
T
I
A
N
L
L
K
-
A
Q
G
-
Y
D
T
A
M
M
-----
G
K
L
H
L
N
A
GGD
R
T
----------
D
Q
------
P
Q
----------------
A
Q
-
D
M
G
F
D
Y
S
L
A
N
T
------------------------------
A
G
F
V
T
D
A
T
L
D
-
N
AKER------
P
R
Y
G
M
V
Y
P
------------
T
GWLRNG
Q
P
T
P
R
A
-
D
K
M
S
G
E
Y
V
S
S
E
V
-----------
V
N
W
L
D
N
K
-
K
D
S
--
K
P
F
F
L
Y
V
A
F
----
T
E
V
H
S
P
L
A
S
-
P
K
------
K
Y
L
D
M
------------
Y
S
---
Q
YMS
A
Y
Q
K
Q
H
-
P
DLFYGDW------------
A
-
D
K
P
-
W
R
G
V
G
E
Y
Y
A
N
I
S
Y
L
D
A
Q
V
G
K
V
L
D
K
I
K
A
M
G
E
E
D
N
T
I
V
I
F
T
S
D
N
G
P
V
-
T
R
E
A
R
K
V
YELN
L
A
G
E
-
T
D
G
-----------------------
L
----------
R
G
----------------------------
R
K
--
D
N
L
W
E
G
G
--
I
R
V
P
A
I
I
K
Y
G
K
H
L
P
Q
-
G
M
V
S
D
T
-
P
V
--
Y
G
L
D
W
M
P
T
L
A
K
M
M
N
F
K
L
P
T
D
R
T
F
D
G
E
S
L
V
P
V
L
E
Q
K
A
L
K
R
-----
E
-------------------------------
K
-
P
L
I
F
G
I
DMPFQDD
P
T
---------
D
E
W
A
I
R
D
G
D
W
K
M
I
I
D
RNNKP
K
Y
L
Y
N
L
K
---
S
D
R
---------------------------------------------------------------------------------------
37
HHSearch
46.68
11%
-25
- C2 -
2X98
16
?
A:
[2-429]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
A
A
N
A
I
A
Y
I
V
D
----
G
M
G
-
Q
T
Q
I
S
A
-
A
R
Y
L
N
A
Y
K
T
APERFPLNVS
P
A
E
T
P
T
G
F
D
A
F
---
S
S
R
G
--
S
---
M
T
T
F
P
-
D
D
P
Y
E
T
T
T
D
S
A
A
A
A
T
A
F
A
S
G
V
K
--
T
Y
N
------
G
A
I
G
G
V
Q
T
SGG---
G
------
F
Q
R
V
D
T
V
L
E
R
A
S
-
A
Q
G
-
Y
A
T
G
L
I
-----
T
T
T
E
A
T
H
---
A
T
P
A
A
F
AAHVED
R
G
N
Q
T
E
I
A
R
Q
----------------
Y
I
E
E
T
Q
P
D
V
I
L
G
G
Q
RRDFEADASNGGT
L
V
D
A
A
R
D
N
G
Y
T
I
A
ET
A
A
E
-
L
------
D
-
A
VDDPP
V
L
G
L
F
S
Q
E----
S
HLDY
Y
L
D
R
K
N
DP
E
-----------
N
-
T
Q
P
N
L
D
A
M
V
D
A
G
-----------
V
D
L
L
S
S
A
G
D
P
D
--
K
G
F
F
L
L
V
E
S
GR
V
D
H
A
G
H
A
N
Y
P
-------------------------------------------------------------------------
A
Q
-
V
A
E
Q
Y
E
A
T
Q
V
A
G
Q
L
V
E
Y
A
E
T
T
--
A
E
P
T
F
L
V
S
T
G
D
H
E
C
G
-
G
L
T
L
G
R
D
SPYEVE
Y
D
V
L
A
A
QKAT
T
S
R
L
R
D
L
L
AGVRS
A
D
E
L
E
S
I
V
A
A
H
------
T
G
I
TALT
D
R
E
V
A
K
L
R
D
APGS
I
S
T
I
L
A
E
R
A
G
I
A
F
-
T
T
D
G
-
H
T
G
-
T
D
V
P
V
F
A
H
G
P
N
A
A
-----
R
F
D
A
-
A
R
--
D
N
T
A
V
A
D
A
L
A
A
A
L
G
V
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
46.34
12%
-30
- C2 -
2W5V
4
?
A:
[30-374]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
K
T
P
K
N
V
I
L
L
I
S
D
----
G
A
G
-
L
S
Q
I
S
S
-
T
F
Y
----------------
F
K
S
G
T
P
N
Y
T
Q
F
---
K
N
I
G
--
L
---
I
K
T
S
S
-
S
R
E
--
D
V
T
D
S
A
S
G
A
T
A
F
S
C
G
I
K
--
T
Y
N
------
A
A
I
G
V
A
D
D
-------------
S
T
A
V
K
S
I
V
E
I
A
A
-
L
N
N
-
I
K
T
G
V
V
-----
A
T
S
S
I
T
D
---
A
T
----------
P
A
------
S
F
YAHALNRG
L
E
E
E
I
A
M
D
M
T
-
E
S
D
L
D
F
F
A
G
G
G
------------------------------
L
-
N
------
Y
--------------------------------
F
-----------
T
-
K
R
K
D
K
K
D
V
L
A
I
L
K
G
NQFTINTTA
L
T
D
F
S
S
I
-
A
S
N
--
R
K
M
G
--
F
L
L
----
A
D
E
A
M
P
T
M
E
K
G
R
G
N
F
L
S
A
A
-
T
D
L
A
I
Q
F
--------
L
S
KD
N
S
A
F
F
I
M
S
EGS
Q
I
-------------------
D
-
W
G
G
H
A
N
N
A
S
Y
L
I
S
E
I
N
D
F
D
D
A
I
G
T
A
L
A
F
A
K
K
D
---
G
N
T
L
V
I
V
T
S
D
H
E
T
G
G
F
T
L
A
A
K
K
---------
N
K
R
-----------------------
E
D
G
S
E
Y
S
DY
T
E
I
G
----------------------------
P
T
F
-
S
T
G
G
-
H
S
A
-
T
L
I
P
V
F
A
Y
G
P
G
S
E
-----
E
F
I
G
-
I
Y
--
E
N
N
E
I
F
H
K
I
L
K
V
T
K
W
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
45.77
13%
-32
- C2 -
1O98
6
GPMI_GEOSE
A:
[230-510]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
F
V
L
P
S
V
I
V
R
E
D
G
RPVA
T
I
Q
D
N
D
A
I
I
F
Y
N
F
R
----------------
P
D
R
A
I
Q
I
S
N
T
F
---
T
N
E
D
--
F
-----
R
E
F
D
R
G
P
---
K
-
H
P
K
H
L
F
F
V
C
L
T
H
F
S
--
E
T
V
------
A
G
Y
V
--
A
F
------
K
P
-----
T
N
L
D
N
T
I
G
E
V
L
S
-
Q
H
G
-
L
R
Q
L
R
I
A
E
TEK
Y
P
H
V
T
F
F
---
M
S
----------
G
G
------
R
E
----------------
E
E
-
F
P
G
E
D
R
I
L
-
I
N
------------------------------
S
-
P
------
K
V
P
----------
T
Y
-----
D
------------
L
-----------
K
-
P
E
M
S
A
Y
E
V
T
D
A
L
-----------
L
K
E
I
E
A
----
D
--
K
Y
D
A
I
I
L
N
Y
----
A
N
P
D
M
V
G
H
---------------------------------------------------------------------
S
G
K
L
E
P
T
I
K
A
V
E
A
V
D
E
C
L
G
K
V
V
D
A
I
L
A
----
K
G
G
I
A
I
I
T
A
D
H
G
N
A
-
D
E
V
L
T
-------------------------------------
P
----------
D
G
----------------------------
K
P
---
Q
T
A
-
H
T
T
-
N
P
V
P
V
I
V
T
K
K
G
I
K
------
L
R
D
-
G
G
--
I
L
G
D
L
A
P
T
M
L
D
L
L
G
L
P
Q
P
K
--
E
M
T
G
K
S
L
I
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------