@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0667: (2016-03-17 )
MTYALEIKGLRKIYSTGVEALRGVDLTVEEGDFYALLGPNGAGKSTTIGIITSLVNKTSGQVSVFGYDLDTDIVRAKQQIGLVPQEFNFNPFETVQQIVVNQAGYYGVSRKEAIKRSEKYLKQSNLWEKRSERARMLSGGMKRRLMIARALMHEPKLLILDEPTAGVDIELRREMWTFLRELNESGTTIILTTHYLEEAEMLCRNIGIIQSGELIENTSMKSLLSKLQFETFIFDLEPYEEAFEITGYNHVFEDKQTLSVEVERNQGVNHIFEQLSEHGIKVLSMRNKSNRLEELFLKITEEKHQVGEKHV
Atome Classification :
(35 SA)
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10...-..---.---..---20........30........40........50........60.---.....--..----70--.--------------.--....--...80......----.-.90----..-.-.-..-..100...-..-..110......-----.120.--.....----.-130........140.......150.......160......----.170.......-180-.-.-.-....190.......200.......210....---...220....-...230.......240---------------------.......250.......260.......270.....-----..280.......290.......300.......310
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
T
Y
A
L
E
I
K
G
L
R
K
I
Y
-
S
T
---
G
---
V
E
---
A
LRGV
D
L
T
VEEG
D
F
Y
A
L
LGPNGAGKS
T
T
I
G
I
I
T
S
L
V
NKTSG
Q
V
---
S
V
F
G
Y--DL----
D
---
T
--------------
D
--
I
V
R
A
--
K
Q
Q
IGLVPQEF----N-F
N
P
----
F
E
-
T
-
V
-
Q
Q
-
I
V
V
NQAGY-YG-V
S
R
K
E
A
I
K
R
S
E
-----
K
Y
L
K
Q--S
N
L
W
E
----
K
-
R
-
S
E
R
A
R
M
L
SG
G
M
K
R
R
L
M
I
A
R
A
L
MHEP
K
L
L
I
L
DEPTAGV
D
----
I
E
L
R
R
E
M
W
T
F
L
-
R
E
L-N-E-S-G
T
T
I
I
L
T
T
H
Y
L
E
E
A
E
M
L
C
R
NIGIIQSGELIE---N
T
S
M
K
S
L
L
S
K
-LQF
E
T
F
I
F
DLE
P
Y
E
E
A
---------------------
F
E
ITGYNHVFEDK
Q
T
L
S
V
E
V
ERNQ
G
V
N
H
I
F
E
Q
L
S
E-----HG
I
K
V
L
S
MRNKS
N
R
L
E
E
L
F
L
K
I
T
E
E
K
H
QVGEKHV
85
Fugue
87.18
26%
-83
- C1 -
3TUZ
3
METN_ECOLI
H:
[23-362]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
I
K
L
S
N
I
T
K
V
F
-
H
Q
---
G
TRT
I
Q
---
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
---
L
V
D
G
Q
--
E
L
TTLS
E
---
S
--------------
E
--
L
T
K
A
--
R
R
Q
I
G
M
I
F
Q
H
F
----
N
-
L
L
S
----
S
R
-
T
-
V
-
F
G
-
N
V
A
L
P
L
E
L
-
D
N
-
T
P
K
D
E
V
K
R
R
V
T
-----
E
L
L
S
L
--
V
G
L
G
D
----
K
-
H
-
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
----
P
A
T
T
R
S
I
L
E
L
L
-
K
D
I
-
N
-
R
-
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
---
Q
D
T
V
S
E
V
F
S
H
-
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
DIPEDYQERLQAEPFTDCVPM
L
R
L
E
F
T
G
Q
S
V
D
A
P
L
L
S
E
T
A
R
R
F
N
V
N
N
N
I
I
S
A
Q
M
D
Y
AGGVK
F
G
I
M
L
T
E
M
H
G
T
Q
Q
D
T
Q
A
A
I
A
W
L
Q
E
H
H
V
K
V
E
V
---
91
Fugue
87.06
28%
-78
- C1 -
3B60
2
MSBA_SALTY
A:
[10-581]
W
Q
T
F
R
R
L
W
P
T
I
A
PFK
A
G
L
I
V
A
G
I
A
L
I
L
N
A
A
S
D
T
F
M
L
S
L
LKPLLDDGFGKTDRSVLLW
M
P
L
V
V
I
G
L
M
I
L
R
G
I
T
S
Y
I
S
S
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
MPVAFFDKQS
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
FYYS
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
V
S
K
R
F
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
KEVLIFGG
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
Q
G
M
K
M
V
S
A
S
S
I
S
D
P
I
I
Q
L
I
A
S
L
A
L
A
F
V
L
Y
A
A
S
FPSVMDSLT
A
G
T
I
T
V
V
F
S
S
M
I
A
L
M
R
P
L
K
S
L
T
N
V
N
A
Q
F
Q
R
G
M
A
A
C
Q
T
L
F
A
I
L
D
SEQEK
D
E
G
K
RVIDR
A
T
G
D
L
E
F
R
N
V
T
F
T
Y
P
G
R
---
E
---
V
P
---
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
D
I
D
E
G
H
I
---
L
M
D
G
H
--
D
L
R---
E
---
Y
--------------
T
--
L
A
S
L
--
R
N
Q
V
A
L
V
S
Q
N
V
----
H
-
L
F
N
----
D
T
-
V
-
A
-
N
N
-
I
A
--
Y
A
R
T
-
E
E
-
Y
S
R
E
Q
I
E
E
A
A
R
M
A
YA
M
D
F
I
N
K
M
D
N
G
L
D
T
----
I
-
I
-
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
----
T
E
S
E
R
A
I
Q
A
A
L
-
D
E
L
-
Q
-
K
-
N
-
R
T
S
L
V
I
A
-
H
R
L
S
T
I
E
Q
-
A
D
E
I
V
V
V
E
D
G
I
I
V
E
---
R
G
T
H
S
E
L
L
A
Q
----------------------------------------------------------------
H
G
V
Y
A
Q
L
H
K
-----
M
Q
F
G
------------------------------
1
PsiBlast_PDB
83.40
35%
-92
- C1 -
1VPL
2
?
A:
[15-247]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
V
V
K
D
L
R
K
R
I
-
G
K
---
K
----
E
---
I
L
K
G
I
S
F
E
I
E
E
G
E
I
F
G
L
I
G
P
N
G
A
G
K
T
T
T
L
R
I
I
S
T
L
I
K
P
S
S
G
I
V
---
T
V
F
G
K
--
N
V
----
V
---
E
--------------
E
--
P
H
E
V
--
R
K
L
I
S
Y
L
P
E
E
A
GAYR
N
-
M
Q
G
----
I
E
-
Y
-
L
-
R
F
-
V
----
A
G
F
-
Y
A
-
S
S
S
S
E
I
E
E
M
V
E
-----
R
A
T
E
I
--
A
G
L
G
E
----
K
-
I
-
K
D
R
V
S
T
Y
S
K
G
M
V
R
K
L
L
I
A
R
A
L
M
V
N
P
R
L
A
I
L
D
E
P
T
S
G
L
D
----
V
L
N
A
R
E
V
R
K
I
L
-
K
Q
A
-
S
-
Q
-
E
-
G
L
T
I
L
V
S
S
H
N
M
L
E
V
E
F
L
C
D
R
I
A
L
I
H
N
G
T
I
V
E
---
T
G
T
V
E
E
L
K
E
R
--------
Y
K
A
Q
N
I
E
E
V
---------------------
F
E
------------------------------------------------------------------------
5
PsiBlast_PDB
81.99
32%
-99
- C1 -
3TUZ
1
METN_ECOLI
C:
[23-253]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
I
K
L
S
N
I
T
K
V
F
-
H
Q
---
G
TRT
I
Q
---
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
---
L
V
D
G
Q
--
E
L
----
T
---
T
LSES----------
E
--
L
T
K
A
--
R
R
Q
I
G
M
I
F
Q
H
F
----
N
-
L
L
S
----
S
R
-
T
-
V
-
F
G
-
N
V
A
L
P
L
E
L
-
D
N
-
T
P
K
D
E
V
K
R
R
V
T
-----
E
L
L
S
L
--
V
G
L
G
D
----
K
-
H
-
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
----
P
A
T
T
R
S
I
L
E
L
L
-
K
D
I
-
N
-
R
-
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
---
Q
D
T
V
S
E
V
F
S
-----------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
81.17
32%
-96
- C1 -
3TUI
1
METN_ECOLI
C:
[23-253]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
I
K
L
S
N
I
T
K
V
F
-
H
Q
---
G
TRT
I
Q
---
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
---
L
V
D
G
Q
--
E
L
----
T
---
T
LSES----------
E
--
L
T
K
A
--
R
R
Q
I
G
M
I
F
Q
H
F
----
N
-
L
L
S
----
S
R
-
T
-
V
-
F
G
-
N
V
A
L
P
L
E
L
-
D
N
-
T
P
K
D
E
V
K
R
R
V
T
-----
E
L
L
S
L
--
V
G
L
G
D
----
K
-
H
-
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
----
P
A
T
T
R
S
I
L
E
L
L
-
K
D
I
-
N
-
R
-
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
---
Q
D
T
V
S
E
V
F
S
-----------------------------------------------------------------------------------------------------------------
80
HHSearch
81.14
36%
-89
- C1 -
1VPL
2
?
A:
[14-238]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
V
V
V
K
D
L
R
K
R
I
-
G
----
K
---
K
E
---
I
L
K
G
I
S
F
E
I
E
E
G
E
I
F
G
L
I
G
P
N
G
A
G
K
T
T
T
L
R
I
I
S
T
L
I
K
P
S
S
G
I
V
---
T
V
F
G
K
--
N
V
----
V
---
E
--------------
E
--
P
H
E
V
--
R
K
L
I
S
Y
L
P
E
E
A
----
G
-
A
Y
R
----
N
M
-
Q
-
G
-
I
E
-
Y
L
R
F
V
A
G
F
-
Y
A
-
S
S
S
S
E
I
E
E
M
V
E
-----
R
A
T
E
I
--
A
G
L
G
E
----
K
-
I
-
K
D
R
V
S
T
Y
S
K
G
M
V
R
K
L
L
I
A
R
A
L
M
V
N
P
R
L
A
I
L
D
E
P
T
S
G
L
D
----
V
L
N
A
R
E
V
R
K
I
L
-
K
Q
A
-
S
-
Q
-
E
-
G
L
T
I
L
V
S
S
H
N
M
L
E
V
E
F
L
C
D
R
I
A
L
I
H
N
G
T
I
V
E
---
T
G
T
V
E
E
L
K
E
R
-
Y
K
-------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
80.42
32%
-89
- C1 -
3TUI
1
METN_ECOLI
G:
[24-253]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
K
L
S
N
I
T
K
V
F
-
H
Q
---
G
TRT
I
Q
---
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
---
L
V
D
G
Q
--
E
L
----
T
---
T
LSES----------
E
--
L
T
K
A
--
R
R
Q
I
G
M
I
F
Q
H
F
----
N
-
L
L
S
----
S
R
-
T
-
V
-
F
G
-
N
V
A
L
P
L
E
L
-
D
N
-
T
P
K
D
E
V
K
R
R
V
T
-----
E
L
L
S
L
--
V
G
L
G
D
----
K
-
H
-
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
----
P
A
T
T
R
S
I
L
E
L
L
-
K
D
I
-
N
-
R
-
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
---
Q
D
T
V
S
E
V
F
S
-----------------------------------------------------------------------------------------------------------------
70
HHSearch
80.33
32%
-94
* C1 *
3TUI
1
METN_ECOLI
C:
[23-256]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
I
K
L
S
N
I
T
K
V
F
-
H
Q
GTR
T
---
I
Q
---
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
---
L
V
D
G
Q
--
E
L
----
T
---
T
LSES----------
E
--
L
T
K
A
--
R
R
Q
I
G
M
I
F
Q
H
F
----
N
-
L
L
S
----
S
R
-
T
-
V
-
F
G
-
N
V
A
L
P
L
E
L
-
D
N
-
T
P
K
D
E
V
K
R
R
V
T
-----
E
L
L
S
L
--
V
G
L
G
D
----
K
-
H
-
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
----
P
A
T
T
R
S
I
L
E
L
L
-
K
D
I
-
N
-
R
R
L
-
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
---
Q
D
T
V
S
E
V
F
S
H
-
P
K
-------------------------------------------------------------------------------------------------------------
83
HHSearch
80.04
31%
-90
- C1 -
1B0U
4
HISP_SALTY
A:
[5-245]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
H
V
I
D
L
H
K
R
Y
-
G
----
G
---
H
E
---
V
L
K
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
E
K
P
S
E
G
A
I
---
I
V
N
G
Q
--
N
I
----
N
---
L
V
R
D
KDGQLKVAD
K
N
Q
--
L
R
L
L
--
R
T
R
L
T
M
V
F
Q
H
F
----
N
-
L
W
S
----
H
M
-
T
-
V
-
L
E
-
N
V
M
E
A
P
I
Q
V
L
G
-
L
S
K
H
D
A
R
E
R
A
L
-----
K
Y
L
A
K
--
V
G
I
D
E
----
R
-
A
Q
G
K
Y
P
V
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
----
P
E
L
V
G
E
V
L
R
I
M
-
Q
Q
L
-
A
-
E
-
E
-
G
K
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
H
Q
G
K
I
E
E
---
E
G
D
P
E
Q
V
F
G
N
-
P
Q
-------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
79.26
32%
-91
- C1 -
3TUI
1
METN_ECOLI
D:
[24-253]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
K
L
S
N
I
T
K
V
F
-
H
Q
---
G
TRT
I
Q
---
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
---
L
V
D
G
Q
--
E
L
----
T
---
T
LSES----------
E
--
L
T
K
A
--
R
R
Q
I
G
M
I
F
Q
H
F
----
N
-
L
L
S
----
S
R
-
T
-
V
-
F
G
-
N
V
A
L
P
L
E
L
-
D
N
-
T
P
K
D
E
V
K
R
R
V
T
-----
E
L
L
S
L
--
V
G
L
G
D
----
K
-
H
-
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
----
P
A
T
T
R
S
I
L
E
L
L
-
K
D
I
-
N
-
R
-
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
---
Q
D
T
V
S
E
V
F
S
-----------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
79.25
32%
-93
- C1 -
3TUZ
1
METN_ECOLI
H:
[23-253]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
I
K
L
S
N
I
T
K
V
F
-
H
Q
---
G
TRT
I
Q
---
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
---
L
V
D
G
Q
--
E
L
----
T
---
T
LSES----------
E
--
L
T
K
A
--
R
R
Q
I
G
M
I
F
Q
H
F
----
N
-
L
L
S
----
S
R
-
T
-
V
-
F
G
-
N
V
A
L
P
L
E
L
-
D
N
-
T
P
K
D
E
V
K
R
R
V
T
-----
E
L
L
S
L
--
V
G
L
G
D
----
K
-
H
-
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
----
P
A
T
T
R
S
I
L
E
L
L
-
K
D
I
-
N
-
R
-
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
---
Q
D
T
V
S
E
V
F
S
-----------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
78.74
32%
-91
- C1 -
3TUI
1
METN_ECOLI
H:
[23-253]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
I
K
L
S
N
I
T
K
V
F
-
H
Q
---
G
TRT
I
Q
---
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
---
L
V
D
G
Q
--
E
L
----
T
---
T
LSES----------
E
--
L
T
K
A
--
R
R
Q
I
G
M
I
F
Q
H
F
----
N
-
L
L
S
----
S
R
-
T
-
V
-
F
G
-
N
V
A
L
P
L
E
L
-
D
N
-
T
P
K
D
E
V
K
R
R
V
T
-----
E
L
L
S
L
--
V
G
L
G
D
----
K
-
H
-
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
----
P
A
T
T
R
S
I
L
E
L
L
-
K
D
I
-
N
-
R
-
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
---
Q
D
T
V
S
E
V
F
S
-----------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
78.54
32%
-91
- C1 -
3TUZ
1
METN_ECOLI
D:
[24-253]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
K
L
S
N
I
T
K
V
F
-
H
Q
---
G
TRT
I
Q
---
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
---
L
V
D
G
Q
--
E
L
----
T
---
T
LSES----------
E
--
L
T
K
A
--
R
R
Q
I
G
M
I
F
Q
H
F
----
N
-
L
L
S
----
S
R
-
T
-
V
-
F
G
-
N
V
A
L
P
L
E
L
-
D
N
-
T
P
K
D
E
V
K
R
R
V
T
-----
E
L
L
S
L
--
V
G
L
G
D
----
K
-
H
-
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
----
P
A
T
T
R
S
I
L
E
L
L
-
K
D
I
-
N
-
R
-
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
---
Q
D
T
V
S
E
V
F
S
-----------------------------------------------------------------------------------------------------------------
74
HHSearch
78.44
31%
-88
- C1 -
3GFO
1
ECFA3_CLOP1
A:
[5-236]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
I
L
K
V
E
E
L
N
Y
N
Y
-
S
D
---
G
---
T
H
---
A
L
K
G
I
N
M
N
I
K
R
G
E
V
T
A
I
L
G
G
N
G
V
G
K
S
T
L
F
Q
N
F
N
G
I
L
K
P
S
S
G
R
I
---
L
F
D
N
K
--
P
I
----
D
---
Y
S
R
K
-----------
G
--
I
M
K
L
--
R
E
S
I
G
I
V
F
Q
D
P
----
D
N
Q
L
F
----
S
A
-
S
-
V
-
Y
Q
-
D
V
S
F
G
A
V
N
-
M
K
-
L
P
E
D
E
I
R
K
R
V
D
-----
N
A
L
K
R
--
T
G
I
E
H
----
L
-
K
-
D
K
P
T
H
C
L
S
F
G
Q
K
K
R
V
A
I
A
G
V
L
V
M
E
P
K
V
L
I
L
D
E
P
T
A
G
L
D
----
P
M
G
V
S
E
I
M
K
L
L
-
V
E
M
-
Q
-
K
E
L
-
G
I
T
I
I
I
A
T
H
D
I
D
I
V
P
L
Y
C
D
N
V
F
V
M
K
E
G
R
V
I
L
---
Q
G
N
P
K
E
V
F
A
E
-
K
E
-------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
78.42
32%
-92
- C1 -
3TUZ
1
METN_ECOLI
G:
[24-253]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
K
L
S
N
I
T
K
V
F
-
H
Q
---
G
TRT
I
Q
---
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
---
L
V
D
G
Q
--
E
L
----
T
---
T
LSES----------
E
--
L
T
K
A
--
R
R
Q
I
G
M
I
F
Q
H
F
----
N
-
L
L
S
----
S
R
-
T
-
V
-
F
G
-
N
V
A
L
P
L
E
L
-
D
N
-
T
P
K
D
E
V
K
R
R
V
T
-----
E
L
L
S
L
--
V
G
L
G
D
----
K
-
H
-
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
----
P
A
T
T
R
S
I
L
E
L
L
-
K
D
I
-
N
-
R
-
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
---
Q
D
T
V
S
E
V
F
S
-----------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
78.15
32%
-93
- C1 -
3DHW
-
METN_ECOLI
C:
[2-230]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
L
S
N
I
T
K
V
F
-
H
Q
---
G
TRT
I
Q
---
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
---
L
V
D
G
Q
--
E
L
----
T
---
T
LSES----------
E
--
L
T
K
A
--
R
R
Q
I
G
M
I
F
Q
H
F
----
N
-
L
L
S
----
S
R
-
T
-
V
-
F
G
-
N
V
A
L
P
L
E
L
-
D
N
-
T
P
K
D
E
V
K
R
R
V
T
-----
E
L
L
S
L
--
V
G
L
G
D
----
K
-
H
-
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
E
A
T
S
A
L
D
----
P
A
T
T
R
S
I
L
E
L
L
-
K
D
I
-
N
-
R
-
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
---
Q
D
T
V
S
E
V
F
S
-----------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
77.30
32%
-91
- C1 -
3GFO
1
ECFA3_CLOP1
A:
[6-233]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
I
L
K
V
E
E
L
N
Y
N
Y
-
S
D
---
G
---
T
H
---
A
L
K
G
I
N
M
N
I
K
R
G
E
V
T
A
I
L
G
G
N
G
V
G
K
S
T
L
F
Q
N
F
N
G
I
L
K
P
S
S
G
R
I
---
L
F
D
N
K
--
P
I
----
D
YS
R
K
--------------
G
--
I
M
K
L
--
R
E
S
I
G
I
V
F
Q
D
P
----
D
-
N
Q
L
----
F
S
A
S
-
V
-
Y
Q
-
D
V
S
F
G
A
V
N
-
M
K
-
L
P
E
D
E
I
R
K
R
V
D
-----
N
A
L
K
R
--
T
G
I
E
H
----
L
-
K
-
D
K
P
T
H
C
L
S
F
G
Q
K
K
R
V
A
I
A
G
V
L
V
M
E
P
K
V
L
I
L
D
E
P
T
A
G
L
D
----
P
M
G
V
S
E
I
M
K
L
L
-
V
E
M
Q
K
-
E
-
L
-
G
I
T
I
I
I
A
T
H
D
I
D
I
V
P
L
Y
C
D
N
V
F
V
M
K
E
G
R
V
I
L
---
Q
G
N
P
K
E
V
F
A
-----------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
75.70
28%
-98
- C1 -
4U00
3
?
A:
[3-228]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
I
I
R
I
R
N
L
H
K
W
F
-
G
P
-------
L
H
---
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
---
V
V
D
G
L
--
S
V
----
K
---
D
--------------
D
RA
L
R
E
I
--
R
R
E
V
G
M
V
F
Q
Q
F
----
N
-
L
F
P
----
H
M
-
T
-
V
L
E
N
-
V
T
L
A
P
M
R
V
-
R
R
-
W
P
R
E
K
A
E
K
K
A
L
-----
E
L
L
E
R
--
V
G
I
L
D
----
Q
-
A
-
R
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
----
P
E
M
V
G
E
V
L
D
V
M
-
R
D
L
-
A
-
Q
-
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
---
E
G
R
P
E
E
I
F
T
R
----------------------------------------------------------------------------------------------------------------
64
HHSearch
70.53
30%
-80
- C1 -
1Z47
1
?
A:
[12-239]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
T
I
E
F
V
G
V
E
K
I
Y
-
P
G
---
G
---
A
R
---
S
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
---
W
I
G
G
K
--
R
V
----
T
---
D
-----------------
L
P
P
Q
--
K
R
N
V
G
L
V
F
Q
N
Y
----
A
-
L
F
Q
----
H
M
-
T
-
V
-
Y
D
-
N
V
S
F
G
L
R
E
-
K
R
-
V
P
K
D
E
M
D
A
R
V
R
-----
E
L
L
R
F
--
M
R
L
E
S
----
Y
-
A
-
N
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
----
T
Q
I
R
R
E
L
R
T
F
V
-
R
Q
V
-
H
-
D
E
M
-
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
Q
---
F
G
T
P
E
E
V
Y
E
K
-
P
G
T
------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
70.26
28%
-94
- C1 -
2OLJ
4
?
A:
[22-253]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
M
I
D
V
H
Q
L
K
K
S
F
-
G
S
-------
L
E
---
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
---
I
I
D
G
I
--
N
L
KAK-
D
---
T
--------------
N
--
L
N
K
V
--
R
E
E
V
G
M
V
F
Q
R
F
----
N
-
L
F
P
----
H
M
-
T
-
V
L
N
N
-
I
T
L
A
P
M
K
V
-
R
K
-
W
P
R
E
K
A
E
A
K
A
M
-----
E
L
L
D
K
--
V
G
L
K
D
----
K
-
A
-
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
----
P
E
M
V
G
E
V
L
S
V
M
-
K
Q
L
-
A
-
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
---
E
G
K
P
E
D
L
F
D
R
-
P
Q
H
E
-----------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
67.92
31%
-77
- C1 -
4QC2
2
?
A:
[4-225]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
A
K
N
L
A
K
A
Y
-
K
----
G
---
R
R
---
V
V
E
D
V
S
L
T
V
N
S
G
E
I
V
G
L
L
G
P
N
G
A
G
K
T
T
T
F
Y
M
V
V
G
I
V
P
R
D
A
G
N
I
---
I
I
D
D
D
DI
S
L
----
L
---
P
--------------
L
--
H
A
R
A
--
R
R
G
I
G
Y
L
P
Q
E
A
----
S
I
F
R
R
----
L
S
-
V
-
Y
-
D
N
-
L
M
A
V
L
Q
I
R
-
D
D
-
L
S
A
E
Q
R
E
D
R
A
N
-----
E
L
M
E
E
--
F
H
I
E
H
----
L
-
R
-
D
S
M
G
Q
S
L
S
G
G
E
R
R
R
V
E
I
A
R
A
L
A
A
N
P
K
F
I
L
L
D
E
P
F
A
G
V
D
P
I
S
V
I
D
I
K
R
----
I
I
-
E
H
L
-
R
-
D
-
S
-
G
L
G
V
L
I
T
D
H
N
V
R
E
T
L
A
V
C
E
R
A
Y
I
V
S
Q
G
H
L
I
A
---
H
G
T
P
T
E
I
L
------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
66.69
31%
-74
- C1 -
4QC2
2
?
B:
[4-225]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
A
K
N
L
A
K
A
Y
-
K
----
G
---
R
R
---
V
V
E
D
V
S
L
T
V
N
S
G
E
I
V
G
L
L
G
P
N
G
A
G
K
T
T
T
F
Y
M
V
V
G
I
V
P
R
D
A
G
N
I
---
I
I
D
D
D
DI
S
L
----
L
---
P
--------------
L
--
H
A
R
A
--
R
R
G
I
G
Y
L
P
Q
E
A
----
S
I
F
R
R
----
L
S
-
V
-
Y
-
D
N
-
L
M
A
V
L
Q
I
R
-
D
D
-
L
S
A
E
Q
R
E
D
R
A
N
-----
E
L
M
E
E
--
F
H
I
E
H
----
L
-
R
-
D
S
M
G
Q
S
L
S
G
G
E
R
R
R
V
E
I
A
R
A
L
A
A
N
P
K
F
I
L
L
D
E
P
F
A
G
V
D
PISV
I
D
I
K
R
----
I
I
-
E
H
L
-
R
-
D
-
S
-
G
L
G
V
L
I
T
D
H
N
V
R
E
T
L
A
V
C
E
R
A
Y
I
V
S
Q
G
H
L
I
A
---
H
G
T
P
T
E
I
L
------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
65.99
31%
-90
- C1 -
4YMU
2
?
A:
[14-216]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
---
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
---
F
I
D
G
V
--
K
I
----
N
NGK
V
--------------
N
--
I
N
K
V
--
R
Q
K
V
G
M
V
F
Q
H
F
----
N
-
L
F
P
----
H
L
-
T
A
I
-
E
N
-
I
T
L
A
P
V
K
V
-
K
K
-
M
N
K
K
E
A
E
E
L
A
V
-----
D
L
L
A
K
--
V
G
L
L
D
----
K
-
K
-
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
----
P
E
M
V
K
E
V
L
N
V
M
-
K
Q
L
-
A
-
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
-----------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
65.28
31%
-89
- C1 -
4YMU
2
?
J:
[14-216]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
---
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
---
F
I
D
G
V
--
K
I
----
N
NGK
V
--------------
N
--
I
N
K
V
--
R
Q
K
V
G
M
V
F
Q
H
F
----
N
-
L
F
P
----
H
L
-
T
A
I
-
E
N
-
I
T
L
A
P
V
K
V
-
K
K
-
M
N
K
K
E
A
E
E
L
A
V
-----
D
L
L
A
K
--
V
G
L
L
D
----
K
-
K
-
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
----
P
E
M
V
K
E
V
L
N
V
M
-
K
Q
L
-
A
-
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
-----------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
65.14
31%
-88
- C1 -
4YMV
1
?
J:
[14-216]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
---
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
---
F
I
D
G
V
--
K
I
----
N
NGK
V
--------------
N
--
I
N
K
V
--
R
Q
K
V
G
M
V
F
Q
H
F
----
N
-
L
F
P
----
H
L
-
T
A
I
-
E
N
-
I
T
L
A
P
V
K
V
-
K
K
-
M
N
K
K
E
A
E
E
L
A
V
-----
D
L
L
A
K
--
V
G
L
L
D
----
K
-
K
-
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
----
P
E
M
V
K
E
V
L
N
V
M
-
K
Q
L
-
A
-
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
-----------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
64.16
31%
-89
- C1 -
4YMV
1
?
A:
[14-216]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
---
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
---
F
I
D
G
V
--
K
I
----
N
NGK
V
--------------
N
--
I
N
K
V
--
R
Q
K
V
G
M
V
F
Q
H
F
----
N
-
L
F
P
----
H
L
-
T
A
I
-
E
N
-
I
T
L
A
P
V
K
V
-
K
K
-
M
N
K
K
E
A
E
E
L
A
V
-----
D
L
L
A
K
--
V
G
L
L
D
----
K
-
K
-
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
----
P
E
M
V
K
E
V
L
N
V
M
-
K
Q
L
-
A
-
N
-
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
-----------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
63.10
34%
-83
- C1 -
3TIF
7
Y796_METJA
B:
[2-209]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
L
K
N
V
T
K
T
Y
-
K
M
---
G
---
E
E
IIY
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
YID
N
I
K
T
N
--
D
L
----
D
---
D
--------------
D
--
E
L
T
K
IR
R
D
K
I
G
F
V
F
Q
Q
F
----
N
-
L
I
P
LLTA
L
E
-
N
-
V
-
E
L
-
P
L
I
F
K
--
Y
-
R
G
A
M
S
G
E
E
R
R
K
R
A
L
-----
E
C
L
K
M
--
A
E
L
E
E
----
R
F
A
-
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
----
S
K
T
G
E
K
I
M
Q
L
L
-
K
K
L
-
N
E
E
-
D
-
G
K
T
V
V
V
V
T
H
D
I
N
V
A
----------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
62.19
34%
-85
- C1 -
1L2T
4
Y796_METJA
B:
[2-209]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
L
K
N
V
T
K
T
Y
-
K
M
---
G
---
E
E
IIY
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
YID
N
I
K
T
N
--
D
L
----
D
---
D
--------------
D
--
E
L
T
K
IR
R
D
K
I
G
F
V
F
Q
Q
F
----
N
-
L
I
P
LLTA
L
E
-
N
-
V
-
E
L
-
P
L
I
F
K
--
Y
-
R
G
A
M
S
G
E
E
R
R
K
R
A
L
-----
E
C
L
K
M
--
A
E
L
E
E
----
R
F
A
-
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
----
S
K
T
G
E
K
I
M
Q
L
L
-
K
K
L
-
N
E
E
-
D
-
G
K
T
V
V
V
V
T
H
D
I
N
V
A
----------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
62.06
34%
-80
- C1 -
3TIF
7
Y796_METJA
A:
[2-209]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
L
K
N
V
T
K
T
Y
-
K
M
---
G
---
E
E
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
--
D
L
----
D
---
D
--------------
D
--
E
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
Q
F
----
N
-
L
I
P
LLT
A
L
E
-
N
-
V
-
E
L
-
P
L
I
F
K
--
Y
-
R
G
A
M
S
G
E
E
R
R
K
R
A
L
-----
E
C
L
K
M
--
A
E
L
E
E
----
R
F
A
-
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
----
S
K
T
G
E
K
I
M
Q
L
L
-
K
K
L
-
N
E
E
-
D
-
G
K
T
V
V
V
V
T
H
D
I
N
V
A
----------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
61.48
34%
-82
- C1 -
1L2T
4
Y796_METJA
A:
[2-209]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
L
K
N
V
T
K
T
Y
-
K
M
---
G
---
E
E
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
I
K
T
N
--
D
L
----
D
---
D
--------------
D
--
E
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
Q
F
----
N
-
L
I
P
LLT
A
L
E
-
N
-
V
-
E
L
-
P
L
I
F
K
--
Y
-
R
G
A
M
S
G
E
E
R
R
K
R
A
L
-----
E
C
L
K
M
--
A
E
L
E
E
----
R
F
A
-
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
----
S
K
T
G
E
K
I
M
Q
L
L
-
K
K
L
-
N
E
E
-
D
-
G
K
T
V
V
V
V
T
H
D
I
N
V
A
----------------------------------------------------------------------------------------------------------------------------------------------
58
PsiBlast_CBE
52.52
31%
-59
- C1 -
2ONJ
4
Y1866_STAAM
B:
[357-565]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
S
G
Q
I
---
L
I
D
G
H
--
N
I
----
K
---
D
--------------
F
--
L
T
G
S
L-
R
N
Q
I
G
L
V
Q
Q
D
-----
N
-
I
L
F
----
S
D
-
T
-
V
-
K
E
N
I
L
L
G
R
P
T
A
-
T
D
-
E
E
V
V
E
A
A
K
M
A
N
-----
A
H
D
F
I
--
M
N
L
P
Q
GYDT
E
-
V
-
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
----
L
E
S
E
S
I
I
Q
E
A
L
-
D
V
L
-
S
-
K
-
D
-
R
T
T
L
I
V
-
A
H
R
L
S
T
I
T
H
-
A
D
K
I
V
V
I
E
N
G
H
I
V
E
---
T
G
T
H
R
E
L
I
A
K
----------------------------------------------------------------------------------------------------------------
59
PsiBlast_CBE
52.38
31%
-59
- C1 -
2ONJ
4
Y1866_STAAM
A:
[357-565]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
S
G
Q
I
---
L
I
D
G
H
--
N
I
----
K
---
D
--------------
F
--
L
T
G
S
L
-
R
N
Q
I
G
L
V
Q
Q
D
-----
N
-
I
L
F
----
S
D
-
T
-
V
-
K
E
N
I
L
L
G
R
P
T
A
-
T
D
-
E
E
V
V
E
A
A
K
M
A
N
-----
A
H
D
F
I
--
M
N
L
P
Q
GYDT
E
-
V
-
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
----
L
E
S
E
S
I
I
Q
E
A
L
-
D
V
L
-
S
-
K
-
D
-
R
T
T
L
I
V
-
A
H
R
L
S
T
I
T
H
-
A
D
K
I
V
V
I
E
N
G
H
I
V
E
---
T
G
T
H
R
E
L
I
A
K
----------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
51.90
31%
-60
- C1 -
2HYD
3
Y1866_STAAM
B:
[357-565]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
S
G
Q
I
---
L
I
D
G
H
--
N
I
----
K
---
D
--------------
F
--
L
T
G
S
L-
R
N
Q
I
G
L
V
Q
Q
D
-----
N
-
I
L
F
----
S
D
-
T
-
V
-
K
E
N
I
L
L
G
R
P
T
A
-
T
D
-
E
E
V
V
E
A
A
K
M
A
N
-----
A
H
D
F
I
--
M
N
L
P
Q
GYDT
E
-
V
-
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
----
L
E
S
E
S
I
I
Q
E
A
L
-
D
V
L
-
S
-
K
-
D
-
R
T
T
L
I
V
-
A
H
R
L
S
T
I
T
H
-
A
D
K
I
V
V
I
E
N
G
H
I
V
E
---
T
G
T
H
R
E
L
I
A
K
----------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
51.64
31%
-59
- C1 -
2HYD
3
Y1866_STAAM
A:
[357-565]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
D
V
T
S
G
Q
I
---
L
I
D
G
H
--
N
I
----
K
---
D
--------------
F
--
L
T
G
S
L
-
R
N
Q
I
G
L
V
Q
Q
D
-----
N
-
I
L
F
----
S
D
-
T
-
V
-
K
E
N
I
L
L
G
R
P
T
A
-
T
D
-
E
E
V
V
E
A
A
K
M
A
N
-----
A
H
D
F
I
--
M
N
L
P
Q
GYDT
E
-
V
-
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
----
L
E
S
E
S
I
I
Q
E
A
L
-
D
V
L
-
S
-
K
-
D
-
R
T
T
L
I
V
-
A
H
R
L
S
T
I
T
H
-
A
D
K
I
V
V
I
E
N
G
H
I
V
E
---
T
G
T
H
R
E
L
I
A
K
----------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
41.84
33%
16
- C1 -
4YER
4
?
A:
[19-303]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
---
A
V
K
G
V
S
F
S
V
K
K
G
E
I
F
A
F
L
G
P
N
G
A
G
K
T
T
T
I
H
M
L
T
T
L
L
K
P
T
S
G
K
A
---
W
V
A
G
H
--
D
V
----
L
---
K
--------------
E
--
P
R
E
V
--
R
R
K
I
G
I
V
F
Q
D
Q
----
S
-
L
D
R
----
E
L
-
T
-
A
-
Y
E
-
N
M
Y
I
H
G
K
I
-
Y
G
-
Y
G
G
E
K
L
K
K
R
I
L
-----
E
L
L
E
F
--
V
E
L
L
E
----
F
-
K
-
D
K
P
V
K
T
F
S
G
G
M
A
R
R
L
E
I
A
R
S
L
I
H
E
P
E
V
L
F
L
D
E
P
T
I
G
L
D
----
P
H
T
R
A
H
M
W
E
Y
I
S
K
M
K
-
K
-
E
-
H
-
N
M
T
I
F
L
T
T
H
Y
M
D
E
A
E
Q
L
A
D
R
V
A
I
I
D
H
G
K
I
I
A
LGT
P
T
E
L
K
R
M
V
G
K
E
I
I
Y
V
R
----------
D
---------------------
F
-
I
E
S
C
R
K
L
P
D
G
R
L
E
L
N
V
E
-
D
-----------------------
I
E
E
I
T
Y
H
K
P
T
L
N
D
V
F
L
H
L
T
-----------