@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0756: (2016-03-18 )
MTERALQVTNLHKKIRKREIIKGISFEVMPGEVFGFLGPNGAGKTTTIRMIVGLIKPTSGTILIGGKDIRKNFTEAMRGLGSIVENPEFYTFLTGQENLAYFARMDSSIKKERIQEVTELVGLEKRINDRVSTYSLGMRQRLGIAQALLSNPKLLILDEPTNGLDPSGIHEMRDFIRALARNEGISVLVSSHLLSEIELLCDRVAIMTDGTIIKTDQVAHLLSSRAQLRWRVTPIEQAKAFLESVTEVEVDGEYLVTAMNEESAEWNEQLVAKGIKVHEIDKRKPSLEDLFLELTGGQSID
Atome Classification :
(27 SA)
.........10.....----.----..---20........30........40........50........60--........----70-.---.----..-..-...-80........90........100--....----------.-----.---.------.----110-..---.......120----------......-----------.----.130.......140.......150.......160.......170.......180.......190.......200.......210.......220-----.......230.......240.......250.......260.....---..270......--.280.......--------290.......300---------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTE
R
A
L
Q
V
T
N
L
H
K
K
I
R
----
K
----
R
E
---
I
IKGI
S
F
E
VMPG
E
V
F
G
F
LGPNGAGK
T
T
T
I
R
M
I
V
G
L
IKPTS
G
T
--
I
L
IG
G
K
D
I
----
R
--
K
---
N
----
F
T
-
E
A
-
M
R
G
-
L
G
S
I
VENP
E
F
Y
T
F
L
TGQE
N
L
A
Y
---
F
A
R
M----------
D
-----
S
---
S
------
I
----
K
---
K
E
---
R
I
Q
E
V
T
E
L
V
-----------
G
L
E
K
R
I
-----------
N
----DR
V
S
T
Y
S
L
G
M
R
Q
R
L
G
I
A
Q
A
L
LSNP
K
L
L
I
L
DEPTNGLD
P
S
G
I
H
E
M
R
D
F
I
R
A
L
A
RNE
G
I
S
V
L
V
S
S
H
L
L
S
E
I
E
L
L
C
D
R
V
A
I
MTD
G
T
I
I
K
T
D
Q
V
A
H
L
L
-----
S
SR
A
Q
L
R
W
RVT
P
I
E
Q
A
K
A
F
L
E
S
V
T
E
V
E
VDG
E
Y
L
V
T
AMNEES
A
E
W
N
---
E
Q
L
V
AKG
I
K
V
H
--EIDKRKP
S
L
E
D
--------
L
F
L
E
LTGGQSID----------------
1
PsiBlast_PDB
93.36
44%
-108
- C1 -
1VPL
2
?
A:
[15-244]
----
A
V
V
V
K
D
L
R
K
R
I
G
----
K
----
K
E
---
I
L
K
G
I
S
F
E
I
E
E
G
E
I
F
G
L
I
G
P
N
G
A
G
K
T
T
T
L
R
I
I
S
T
L
I
K
P
S
S
G
I
--
V
T
V
F
G
K
N
V
----
V
--
E
---
E
----
P
H
-
E
V
-
R
K
L
-
I
S
Y
L
P
E
E
A
G
A
Y
R
N
M
Q
G
I
E
Y
L
R
F
V
A
G
F
Y
A
S
----------
S
-----
S
---
S
------
E
----
I
---
E
E
---
M
V
E
R
A
T
E
I
A
-----------
G
L
G
E
K
I
-----------
K
----
D
R
V
S
T
Y
S
K
G
M
V
R
K
L
L
I
A
R
A
L
M
V
N
P
R
L
A
I
L
D
E
P
T
S
G
L
D
V
L
N
A
R
E
V
R
K
I
L
K
Q
-
A
S
Q
E
G
L
T
I
L
V
S
S
H
N
M
L
E
V
E
F
L
C
D
R
I
A
L
I
H
N
G
T
I
V
E
T
G
T
V
E
E
L
----------
K
E
R
Y
K
A
Q
N
I
E
E
---------------------------------------------------------------------------------------------
73
HHSearch
92.05
45%
-113
- C1 -
1VPL
2
?
A:
[14-238]
---
G
A
V
V
V
K
D
L
R
K
R
I
G
----
K
----
K
E
---
I
L
K
G
I
S
F
E
I
E
E
G
E
I
F
G
L
I
G
P
N
G
A
G
K
T
T
T
L
R
I
I
S
T
L
I
K
P
S
S
G
I
--
V
T
V
F
G
K
N
V
----
V
--
E
---
E
----
P
H
-
E
V
-
R
K
L
-
I
S
Y
L
P
E
E
A
G
A
Y
R
N
M
Q
G
I
E
Y
L
R
F
---
V
A
G
F
----------
Y
-----
A
---
S
------
S
----
S
S
E
I
E
E
---
M
V
E
R
A
T
E
I
A
-----------
G
L
G
E
K
I
-----------
K
----
D
R
V
S
T
Y
S
K
G
M
V
R
K
L
L
I
A
R
A
L
M
V
N
P
R
L
A
I
L
D
E
P
T
S
G
L
D
V
L
N
A
R
E
V
R
K
I
L
K
Q
A
S
Q
-
E
G
L
T
I
L
V
S
S
H
N
M
L
E
V
E
F
L
C
D
R
I
A
L
I
H
N
G
T
I
V
E
T
G
T
V
E
E
L
K
-----
E
R
Y
K
--------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
78.73
29%
-109
- C1 -
3TUI
1
METN_ECOLI
C:
[34-276]
----------
F
H
Q
G
T
R
----
T
----
I
Q
---
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
--
V
L
V
D
G
Q
E
L
TTLS
E
--
S
---
E
----
L
T
-
K
A
-
R
R
Q
-
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
---
P
L
E
L
----------
D
-----
N
---
T
------
P
----
K
---
D
E
VKR
R
V
T
E
L
L
S
L
V
-----------
G
L
G
D
K
H
-----------
D
----
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
-----
S
H
P
K
------
T
P
L
--
A
Q
K
F
I
Q
S
T
L
H
L
D
I
P
E
D
Y
----------------------------------------------------------------------------
66
HHSearch
78.40
28%
-98
- C1 -
2OLJ
4
?
A:
[22-250]
--
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
----
S
----
L
E
---
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
--
I
I
I
D
G
I
N
L
----
K
--
A
KDT
N
----
L
N
-
K
V
-
R
E
E
-
V
G
M
V
F
Q
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
L
---
A
P
M
K
----------
V
-----
R
---
K
WP
R
E
--
K
----
A
---
E
A
---
K
A
M
E
L
L
D
K
V
-----------
G
L
K
D
K
A
-----------
H
----
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
A
N
-
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
-----
D
R
P
---------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
77.37
32%
-103
- C1 -
4AYX
2
ABCBA_HUMAN
A:
[341-570]
----
A
L
E
F
K
N
V
H
F
A
Y
P
----
A
----
R
P
EVP
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
S
G
T
--
I
S
L
D
G
H
D
I
----
R
--
Q
---
L
----
N
P
-
V
W
-
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
-
C
S
I
A
E
N
I
A
Y
---
G
A
D
D
----------
P
-----
S
---
S
------
V
----
T
---
A
E
---
E
I
Q
R
V
A
E
V
A
NA
V
A
F
I
R
N
FPQ
G
F
N
T
V
V
-----------
G
----
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
--
D
G
R
T
V
L
V
I
A
H
R
L
S
T
I
K
-
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
-----
S
-----------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
76.44
29%
-110
- C1 -
3TUZ
1
METN_ECOLI
C:
[34-276]
----------
F
H
Q
G
T
R
----
T
----
I
Q
---
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
--
V
L
V
D
G
Q
E
L
TTLS
E
--
S
---
E
----
L
T
-
K
A
-
R
R
Q
-
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
---
P
L
E
L
----------
D
-----
N
---
T
------
P
----
K
---
D
E
VKR
R
V
T
E
L
L
S
L
V
-----------
G
L
G
D
K
H
-----------
D
----
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
-----
S
H
P
K
------
T
P
L
--
A
Q
K
F
I
Q
S
T
L
H
L
D
I
P
E
D
Y
----------------------------------------------------------------------------
75
Fugue
75.95
24%
-97
- C1 -
3TUZ
3
METN_ECOLI
H:
[23-362]
---
H
M
I
K
L
S
N
I
T
K
V
F
H
QGTR
T
----
I
Q
---
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
--
V
L
V
D
G
Q
E
L
TTLS
E
--
S
---
E
----
L
T
-
K
A
-
R
R
Q
-
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
---
P
L
E
L
----------
D
-----
N
TPK
D
------
E
----
V
---
K
R
---
R
V
T
E
L
L
S
L
V
-----------
G
L
G
D
K
H
-----------
D
----
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
SHPKT
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
I
P
E
D
Y
Q
E
R
L
Q
A
E
P
F
T
D
C
V
P
M
L
R
L
E
F
T
G
Q
S
V
D
---
A
P
L
L
S
E
T
A
R
R
F
NV
N
N
N
I
I
S
A
Q
M
D
Y
AGGVKFGI
M
L
T
E
M
H
G
T
Q
Q
D
T
QAAIAWLQEHHVKVEV
60
HHSearch
75.81
29%
-91
- C1 -
3RLF
3
MALK_ECOLI
A:
[2-226]
---
A
S
V
Q
L
Q
N
V
T
K
A
W
G
----
E
----
V
V
---
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
--
L
F
I
G
E
K
R
M
----
N
--
D
---
T
-----
P
-
P
A
-
E
R
G
-
V
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
---
G
L
K
L
----------
A
-----
G
---
A
------
K
----
K
E
V
I
N
Q
---
R
V
N
Q
V
A
E
V
L
-----------
Q
L
A
H
L
L
-----------
D
----
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
R
L
G
R
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
G
K
P
L
E
L
Y
-----
H
Y
P
A
--------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
75.58
32%
-105
- C1 -
4AYW
1
ABCBA_HUMAN
A:
[372-598]
----
A
L
E
F
K
N
V
H
F
A
Y
P
----
A
----
R
P
EVP
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
S
G
T
--
I
S
L
D
G
H
D
I
----
R
--
Q
---
L
----
N
P
-
V
W
-
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
-
C
S
I
A
E
N
I
A
Y
---
G
A
D
D
----------
P
-----
S
---
S
------
V
----
T
---
A
E
---
E
I
Q
R
V
A
E
V
A
NA
V
A
F
I
R
N
FPQ
G
F
N
T
V
V
-----------
G
----
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
----
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
--
D
G
R
T
V
L
V
I
A
H
H
L
S
T
I
K
-
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
-------------------------------------------------------------------------------------------------------------------
62
HHSearch
75.35
31%
-107
* C1 *
3TUI
1
METN_ECOLI
C:
[23-255]
---
H
M
I
K
L
S
N
I
T
K
V
F
H
----
Q
GTRT
I
Q
---
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
--
V
L
V
D
G
Q
E
L
----
T
--
T
---
L
SESE
L
T
-
K
A
-
R
R
Q
-
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
---
P
L
E
L
----------
D
-----
N
---
T
------
P
----
K
DEV
K
R
---
R
V
T
E
L
L
S
L
V
-----------
G
L
G
D
K
H
-----------
D
----
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
-----
S
H
P
---------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
74.55
31%
-89
- C1 -
3FVQ
3
FBPC_NEIG1
A:
[4-238]
----
A
L
H
I
G
H
L
S
K
S
F
Q
----
N
----
T
P
---
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
--
I
S
L
S
G
K
T
I
FSK-
N
--
T
---
N
----
L
P
-
V
R
-
E
R
R
-
L
G
Y
L
V
Q
E
G
V
L
F
P
H
L
T
V
Y
R
N
I
A
Y
GLG
N
G
K
G
----------
R
-----
T
---
A
------
Q
----
E
---
R
Q
---
R
I
E
A
M
L
E
L
T
-----------
G
I
S
E
L
A
-----------
G
----
R
Y
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
N
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
Q
T
A
S
P
H
E
L
Y
-----
R
Q
P
A
D
L
------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
73.33
31%
-92
- C1 -
3FVQ
3
FBPC_NEIG1
B:
[4-233]
----
A
L
H
I
G
H
L
S
K
S
F
Q
----
N
----
T
P
---
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
--
I
S
L
S
G
K
T
I
FSK-
N
--
T
---
N
----
L
P
-
V
R
-
E
R
R
-
L
G
Y
L
V
Q
E
G
V
L
F
P
H
L
T
V
Y
R
N
I
A
Y
GLG
N
G
K
G
----------
R
-----
T
---
A
------
Q
----
E
---
R
Q
---
R
I
E
A
M
L
E
L
T
-----------
G
I
S
E
L
A
-----------
G
----
R
Y
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
N
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
Q
T
A
S
P
H
E
L
Y
-----
R
Q
P
A
D
L
------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
73.25
32%
-98
- C1 -
4AYT
2
ABCBA_HUMAN
A:
[341-567]
----
A
L
E
F
K
N
V
H
F
A
Y
P
----
A
----
R
P
EVP
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
S
G
T
--
I
S
L
D
G
H
D
I
----
R
--
Q
---
L
----
N
P
-
V
W
-
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
-
C
S
I
A
E
N
I
A
Y
---
G
A
D
D
----------
P
-----
S
---
S
------
V
----
T
---
A
E
---
E
I
Q
R
V
A
E
V
A
NA
V
A
F
I
R
N
FPQ
G
F
N
T
V
V
-----------
G
----
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
--
D
G
R
T
V
L
V
I
A
H
R
L
S
T
I
K
-
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
-------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
72.43
30%
-102
- C1 -
3DHW
-
METN_ECOLI
C:
[11-253]
----------
F
H
Q
G
T
R
----
T
----
I
Q
---
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
--
V
L
V
D
G
Q
E
L
TTLS
E
--
S
---
E
----
L
T
-
K
A
-
R
R
Q
-
I
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
---
P
L
E
L
----------
D
-----
N
---
T
------
P
----
K
DEV
K
R
---
R
V
T
E
L
L
S
L
V
-----------
G
L
G
D
K
H
-----------
D
----
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
E
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
-----
S
H
P
K
------
T
P
L
--
A
Q
K
F
I
Q
S
T
L
H
L
D
I
P
E
D
Y
----------------------------------------------------------------------------
63
HHSearch
71.95
28%
-86
- C1 -
1OXX
21
?
K:
[1-233]
--
M
V
R
I
I
V
K
N
V
S
K
V
F
K
----
K
GK--
V
V
---
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
--
L
Y
F
D
D
R
L
V
----
A
--
S
---
N
GKLI
V
P
-
P
E
-
D
R
K
-
I
G
M
V
F
Q
T
W
A
L
Y
P
N
L
T
A
F
E
N
I
A
F
---
P
L
T
N
----------
M
-----
K
---
M
------
S
KEE-
I
---
R
K
---
R
V
E
E
V
A
K
I
L
-----------
D
I
H
H
V
L
-----------
N
----
H
F
P
R
E
L
S
G
A
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
S
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
K
L
V
Q
V
G
K
P
E
D
L
Y
-----
D
N
P
V
--------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
71.90
33%
-96
- C1 -
4WBS
1
?
B:
[36-257]
-
T
S
S
S
L
V
V
R
N
L
K
K
R
Y
G
----
S
----
R
T
---
V
V
K
D
V
S
L
D
V
K
S
G
E
V
V
G
L
L
G
P
N
G
A
G
K
T
T
S
F
Y
M
I
V
G
L
V
P
L
D
A
G
E
--
I
D
L
D
G
K
S
I
----
S
LL
P
---
I
----
H
K
-
R
A
-
S
L
G
-
L
S
Y
L
P
Q
E
A
S
V
F
R
K
L
S
V
E
E
N
I
R
A
---
V
L
E
L
----------
Q
VGG--
K
---
R
------
L
----
S
---
K
D
---
A
I
A
S
R
T
E
A
L
-----------
L
D
E
L
Q
I
-----------
S
HLRE
N
P
A
L
S
L
S
G
G
E
R
R
R
V
E
I
A
R
A
L
A
T
N
P
S
F
I
L
L
D
E
P
F
A
G
V
D
P
I
A
V
L
E
I
Q
K
I
V
K
F
L
-
K
Q
R
N
I
G
V
L
I
T
D
H
N
V
R
E
T
L
G
I
C
D
H
A
Y
I
I
S
D
G
S
V
L
--------------------------------------------------------------------------------------------------------------------------
74
HHSearch
71.52
26%
-96
- C1 -
1G6H
3
LIVG_METJA
A:
[4-244]
-
T
M
E
I
L
R
T
E
N
I
V
K
Y
F
G
----
E
----
F
K
---
A
L
D
G
V
S
I
S
V
N
K
G
D
V
T
L
I
I
G
P
N
G
S
G
K
S
T
L
I
N
V
I
T
G
F
L
K
A
D
E
G
R
--
V
Y
F
E
N
K
D
I
----
T
--
N
---
K
----
E
P
A
E
L
Y
H
Y
G
-
I
V
R
T
F
Q
T
P
Q
P
L
K
E
M
T
V
L
E
N
L
L
I
---
G
E
I
C
PGES
P
L
N
S
L
F
Y
-----
K
---
K
WIPKE
E
E
----
M
---
V
E
---
K
A
F
K
I
L
E
F
L
-----------
K
L
S
H
L
Y
-----------
D
----
R
K
A
G
E
L
S
G
G
Q
M
K
L
V
E
I
G
R
A
L
M
T
N
P
K
M
I
V
M
D
E
P
I
A
G
V
A
P
G
L
A
H
D
I
F
N
H
V
L
E
L
K
A
-
K
G
I
T
F
L
I
I
E
H
R
L
D
I
V
L
N
Y
I
D
H
L
Y
V
M
F
N
G
Q
I
I
A
E
G
R
G
E
E
E
I
-----
K
N
V
---------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
71.51
33%
-100
- C1 -
4WBS
1
?
A:
[37-257]
--
S
S
S
L
V
V
R
N
L
K
K
R
Y
G
----
S
----
R
T
---
V
V
K
D
V
S
L
D
V
K
S
G
E
V
V
G
L
L
G
P
N
G
A
G
K
T
T
S
F
Y
M
I
V
G
L
V
P
L
D
A
G
E
--
I
D
L
D
G
K
S
I
----
S
LL
P
---
I
----
H
K
-
R
A
-
S
L
G
-
L
S
Y
L
P
Q
E
A
S
V
F
R
K
L
S
V
E
E
N
I
R
A
---
V
L
E
L
----------
Q
VGDDG
K
---
R
------
L
----
S
---
K
D
---
A
I
A
S
R
T
E
A
L
-----------
L
D
E
L
Q
I
-----------
S
HLRE
N
P
A
L
S
L
S
G
G
E
R
R
R
V
E
I
A
R
A
L
A
T
N
P
S
F
I
L
L
D
E
P
F
A
G
V
D
P
I
A
V
L
E
I
Q
K
I
V
K
F
L
-
K
Q
R
N
I
G
V
L
I
T
D
H
N
V
R
E
T
L
G
I
C
D
H
A
Y
I
I
S
D
G
S
V
L
--------------------------------------------------------------------------------------------------------------------------
70
HHSearch
71.35
34%
-99
- C1 -
3ZDQ
-
ABCBA_HUMAN
A:
[340-572]
---
G
A
L
E
F
K
N
V
H
F
A
Y
P
----
A
RPE-
V
P
---
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
S
G
T
--
I
S
L
D
G
H
D
I
----
R
--
Q
L--
N
----
P
V
-
W
L
-
R
S
K
-
I
G
T
V
S
Q
E
P
I
L
F
-
S
C
S
I
A
E
N
I
A
Y
---
G
A
D
D
----------
P
-----
S
---
S
------
V
----
T
---
A
E
---
E
I
Q
R
V
A
E
V
A
-----------
N
A
V
A
F
I
R
N
FPQGFN
T
V
V
G
----
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
--
D
G
R
T
V
L
V
I
A
H
R
L
S
T
I
-
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
-----
S
K
P
---------------------------------------------------------------------------------------------------------
61
HHSearch
70.87
31%
-90
- C1 -
2YYZ
3
?
A:
[2-225]
---
P
S
I
R
V
V
N
L
K
K
Y
F
G
----
K
----
V
K
---
A
V
D
G
V
S
F
E
V
K
D
G
E
F
V
A
L
L
G
P
S
G
C
G
K
T
T
T
L
L
M
L
A
G
I
Y
K
P
T
S
G
E
--
I
Y
F
D
D
V
L
V
----
N
--
D
---
I
----
P
--
P
K
-
Y
R
E
-
V
G
M
V
F
Q
N
Y
A
L
Y
P
H
M
T
V
F
E
N
I
A
F
---
P
L
R
A
----------
R
-----
R
---
I
------
S
----
K
D
E
V
E
K
---
R
V
V
E
I
A
R
K
L
-----------
L
I
D
N
L
L
-----------
D
----
R
K
P
T
Q
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
Q
P
K
V
L
L
F
D
E
P
L
S
N
L
D
A
N
L
R
M
I
M
R
A
E
I
K
H
L
Q
Q
E
L
G
I
T
S
V
Y
V
T
H
D
Q
A
E
A
M
T
M
A
S
R
I
A
V
F
N
Q
G
K
L
V
Q
Y
G
T
P
D
E
V
Y
-----
D
S
P
---------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
65.78
31%
-87
- C1 -
4P32
2
LPTB_ECOLI
A:
[3-215]
-----
L
T
A
K
N
L
A
K
A
Y
K
----
G
----
R
R
---
V
V
E
D
V
S
L
T
V
N
S
G
E
I
V
G
L
L
G
P
N
G
A
G
K
T
T
T
F
Y
M
V
V
G
I
V
P
R
D
A
G
N
I
I
I
D
D
D
D
I
S
L
----
L
--
P
---
L
----
H
A
-
R
A
-
R
R
G
-
I
G
Y
L
P
Q
E
A
S
I
F
R
R
L
S
V
Y
D
N
L
M
A
---
V
L
Q
I
----------
R
-----
D
---
D
------
L
S
A
E
Q
R
---
E
D
---
R
A
N
E
L
M
E
E
F
-----------
H
I
E
H
L
R
-----------
D
----
S
M
G
Q
S
L
S
G
G
E
R
R
R
V
E
I
A
R
A
L
A
A
N
P
K
F
I
L
L
D
E
P
F
A
G
V
D
P
I
S
V
I
D
I
K
R
I
I
E
H
L
-
R
D
S
G
L
G
V
L
I
T
D
H
N
V
R
E
T
L
A
V
C
E
R
A
Y
I
V
S
Q
G
H
L
I
--------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
65.19
31%
-90
- C1 -
4P32
2
LPTB_ECOLI
B:
[3-215]
-----
L
T
A
K
N
L
A
K
A
Y
K
----
G
----
R
R
---
V
V
E
D
V
S
L
T
V
N
S
G
E
I
V
G
L
L
G
P
N
G
A
G
K
T
T
T
F
Y
M
V
V
G
I
V
P
R
D
A
G
N
II
I
D
D
D
D
I
S
L
----
L
--
P
---
L
----
H
A
-
R
A
-
R
R
G
-
I
G
Y
L
P
Q
E
A
S
I
F
R
R
L
S
V
Y
D
N
L
M
A
---
V
L
Q
I
----------
R
-----
D
---
D
------
L
SAEQ
R
---
E
D
---
R
A
N
E
L
M
E
E
F
-----------
H
I
E
H
L
R
-----------
D
----
S
M
G
Q
S
L
S
G
G
E
R
R
R
V
E
I
A
R
A
L
A
A
N
P
K
F
I
L
L
D
E
P
F
A
G
V
D
P
I
S
V
I
D
I
K
R
I
I
E
H
L
-
R
D
S
G
L
G
V
L
I
T
D
H
N
V
R
E
T
L
A
V
C
E
R
A
Y
I
V
S
Q
G
H
L
I
--------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
64.37
31%
-88
- C1 -
4P33
6
LPTB_ECOLI
B:
[3-215]
-----
L
T
A
K
N
L
A
K
A
Y
K
----
G
----
R
R
---
V
V
E
D
V
S
L
T
V
N
S
G
E
I
V
G
L
L
G
P
N
G
A
G
K
T
T
T
F
Y
M
V
V
G
I
V
P
R
D
A
G
N
II
I
D
D
D
D
I
S
L
----
L
--
P
---
L
----
H
A
-
R
A
-
R
R
G
-
I
G
Y
L
P
Q
E
A
S
I
F
R
R
L
S
V
Y
D
N
L
M
A
---
V
L
Q
I
----------
R
-----
D
---
D
------
L
SAEQ
R
---
E
D
---
R
A
N
E
L
M
E
E
F
-----------
H
I
E
H
L
R
-----------
D
----
S
M
G
Q
S
L
S
G
G
E
R
R
R
V
E
I
A
R
A
L
A
A
N
P
K
F
I
L
L
D
Q
P
F
A
G
V
D
P
I
S
V
I
D
I
K
R
I
I
E
H
L
-
R
D
S
G
L
G
V
L
I
T
D
H
N
V
R
E
T
L
A
V
C
E
R
A
Y
I
V
S
Q
G
H
L
I
--------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
62.94
31%
-83
- C1 -
4QC2
2
?
B:
[4-216]
-----
L
T
A
K
N
L
A
K
A
Y
K
----
G
----
R
R
---
V
V
E
D
V
S
L
T
V
N
S
G
E
I
V
G
L
L
G
P
N
G
A
G
K
T
T
T
F
Y
M
V
V
G
I
V
P
R
D
A
G
N
II
I
D
D
D
D
I
S
L
----
L
--
P
---
L
----
H
A
-
R
A
-
R
R
G
-
I
G
Y
L
P
Q
E
A
S
I
F
R
R
L
S
V
Y
D
N
L
M
A
---
V
L
Q
I
----------
R
-----
D
---
D
------
L
SAEQ
R
---
E
D
---
R
A
N
E
L
M
E
E
F
-----------
H
I
E
H
L
R
-----------
D
----
S
M
G
Q
S
L
S
G
G
E
R
R
R
V
E
I
A
R
A
L
A
A
N
P
K
F
I
L
L
D
E
P
F
A
G
V
D
P
I
S
V
I
D
I
K
R
I
I
E
H
L
-
R
D
S
G
L
G
V
L
I
T
D
H
N
V
R
E
T
L
A
V
C
E
R
A
Y
I
V
S
Q
G
H
L
I
--------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
62.22
31%
-83
- C1 -
4QC2
2
?
A:
[4-216]
-----
L
T
A
K
N
L
A
K
A
Y
K
----
G
----
R
R
---
V
V
E
D
V
S
L
T
V
N
S
G
E
I
V
G
L
L
G
P
N
G
A
G
K
T
T
T
F
Y
M
V
V
G
I
V
P
R
D
A
G
N
I
I
I
D
D
D
D
I
S
L
----
L
--
P
---
L
----
H
A
-
R
A
-
R
R
G
-
I
G
Y
L
P
Q
E
A
S
I
F
R
R
L
S
V
Y
D
N
L
M
A
---
V
L
Q
I
----------
R
-----
D
---
D
------
L
S
A
E
Q
R
---
E
D
---
R
A
N
E
L
M
E
E
F
-----------
H
I
E
H
L
R
-----------
D
----
S
M
G
Q
S
L
S
G
G
E
R
R
R
V
E
I
A
R
A
L
A
A
N
P
K
F
I
L
L
D
E
P
F
A
G
V
D
P
I
S
V
I
D
I
K
R
I
I
E
H
L
-
R
D
S
G
L
G
V
L
I
T
D
H
N
V
R
E
T
L
A
V
C
E
R
A
Y
I
V
S
Q
G
H
L
I
--------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
52.51
35%
2
- C1 -
4YER
4
?
A:
[8-304]
-------
V
E
N
L
V
K
K
F
G
----
D
----
F
E
---
A
V
K
G
V
S
F
S
V
K
K
G
E
I
F
A
F
L
G
P
N
G
A
G
K
T
T
T
I
H
M
L
T
T
L
L
K
P
T
S
G
K
--
A
W
V
A
G
H
D
V
----
L
--
K
---
E
----
P
R
-
E
V
-
R
R
K
-
I
G
I
V
F
Q
D
Q
S
L
D
R
E
L
T
A
Y
E
N
M
Y
I
---
H
G
K
I
Y
G
Y
-------
G
-----
G
---
E
------
K
----
L
---
K
K
---
R
I
L
E
L
L
E
F
V
-----------
E
L
L
E
F
K
-----------
D
----
K
P
V
K
T
F
S
G
G
M
A
R
R
L
E
I
A
R
S
L
I
H
E
P
E
V
L
F
L
D
E
P
T
I
G
L
D
P
H
T
R
A
H
M
W
E
Y
I
S
K
M
K
K
E
H
N
M
T
I
F
L
T
T
H
Y
M
D
E
A
E
Q
L
A
D
R
V
A
I
I
D
H
G
K
I
I
-------
A
L
-----
G
T
P
T
E
L
K
R
M
V
G
K
E
I
I
Y
V
R
----------
D
F
I
E
S
C
R
K
L
P
D
G
R
L
E
L
N
V
E
D---------
I
E
--
E
I
T
Y
H
K
P
T
L
N
D
--------
V
F
L
H
L
T
G
---------------------
17
PsiBlast_PDB
34.79
31%
-14
- C1 -
4P31
2
LPTB_ECOLI
A:
[3-215]
-----
L
T
A
K
N
L
A
K
A
Y
K
----
G
----
R
R
---
V
V
E
D
V
S
L
T
V
N
S
G
E
I
V
G
L
L
G
P
N
G
A
G
K
T
T
T
F
Y
M
V
V
G
I
V
P
R
D
A
G
N
I
I
I
D
D
D
D
I
S
L
----
L
--
P
---
L
----
H
A
-
R
A
-
R
R
G
-
I
G
Y
L
P
Q
E
A
S
I
F
R
R
L
S
V
Y
D
N
L
M
A
---
V
L
Q
I
----------
R
-----
D
---
D
------
L
S
A
E
Q
R
---
E
D
---
R
A
N
E
L
M
E
E
F
-----------
H
I
E
H
L
R
-----------
D
----
S
M
G
Q
S
L
S
G
G
E
R
R
R
V
E
I
A
R
A
L
A
A
N
P
K
F
I
L
L
D
E
P
F
A
G
V
D
P
I
S
V
I
D
I
K
R
I
I
E
H
L
-
R
D
S
G
L
G
V
L
I
T
D
H
N
V
R
E
T
L
A
V
C
E
R
A
Y
I
V
S
Q
G
H
L
I
--------------------------------------------------------------------------------------------------------------------------