@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo0979: (2016-03-20 )
MKEVMIKATGLEKSFKKTEVLKGVDFEVKHGEIFALLGSNGAGKTTTIQILATLLKADNGNAHISGFDVKTEPEKVRKHISLTGQFAAVDGLLTGRENILLIAKLRGEKNPAQTADDLLARFGLEKAADRRADTYSGGMTRRLDIAMSLVGSPDVIFLDEPTTGLDPEGRMEVWKTIKTLSDGGTTILLTTQYLDEAEQLADRIAILHGGTIIANGTLDELKKLFPPAEVEYIEKQPSLEEIFLAIINGKEEVK
Atome Classification :
(30 SA)
.........10........20........30........40........50........60........---70--.---..--......80........90.-.......100---.....---.--.--110..---..----...120----.......130.......140.......150.......160.......170.....-..180.......190.......200.......210.......220.......230.......240.......250..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
K
E
V
M
I
K
ATGLE
K
S
F
K
K
T
E
VLKGV
D
F
E
V
KH
G
E
I
F
A
L
LGSNGAGK
T
T
T
I
Q
I
L
A
T
L
L
KADNGN
A
H
I
SGFDV---K---T---
E
P
--
E
K
V
R
K
H
I
SLTG
Q
F
A
A
V
D
G
L-LTGRE
N
I
L
L
I
---
A
KLRG---E--K--NPA
Q
T
---
A
D
----
D
L
L
A
R
F----G
L
E
K
A
ADRRADTYSGGM
T
R
R
L
D
I
A
M
S
LVGSP
D
V
I
F
L
DEPTTGLDP
E
G
R
M
E
V
W
K
T
I
-
K
T
LSDG
G
T
T
I
L
L
T
T
Q
Y
L
D
E
A
E
Q
L
A
D
R
I
A
I
L
HG
G
T
I
I
ANG
T
L
D
E
L
K
K
LFPP
A
E
V
E
Y
I
EKQP
S
L
E
E
I
F
L
A
I
INGKEEVK
85
HHSearch
87.67
39%
-104
- C1 -
1VPL
2
?
A:
[16-251]
-----
V
V
V
K
D
L
R
K
R
I
G
K
K
E
I
L
K
G
I
S
F
E
I
E
E
G
E
I
F
G
L
I
G
P
N
G
A
G
K
T
T
T
L
R
I
I
S
T
L
I
K
P
S
S
G
I
V
T
V
F
G
K
N
V
---
V
---
E
---
E
P
--
H
E
V
R
K
L
I
S
Y
L
P
E
E
A
G
A
Y
R
N
-
M
Q
G
I
E
Y
L
R
F
V
---
A
G
F
Y
A
---
S
--
S
S
S
E
I
E
E
M
---
V
E
----
R
A
T
E
I
A
----
G
L
G
E
K
I
K
D
R
V
S
T
Y
S
K
G
M
V
R
K
L
L
I
A
R
A
L
M
V
N
P
R
L
A
I
L
D
E
P
T
S
G
L
D
V
L
N
A
R
E
V
R
K
I
L
-
K
Q
A
S
Q
E
G
L
T
I
L
V
S
S
H
N
M
L
E
V
E
F
L
C
D
R
I
A
L
I
H
N
G
T
I
V
E
T
G
T
V
E
E
L
K
E
R
Y
K
A
---------
Q
N
I
E
E
V
F
E
E
V
V
K
------
2
PsiBlast_PDB
83.36
38%
-107
- C1 -
1VPL
2
?
A:
[21-251]
----------
L
R
K
R
I
G
K
K
E
I
L
K
G
I
S
F
E
I
E
E
G
E
I
F
G
L
I
G
P
N
G
A
G
K
T
T
T
L
R
I
I
S
T
L
I
K
P
S
S
G
I
V
T
V
F
G
K
N
V
---
V
---
E
---
E
P
--
H
E
V
R
K
L
I
S
Y
L
P
E
E
A
G
A
Y
R
N
-
M
Q
G
I
E
Y
L
R
F
V
---
A
G
F
Y
A
---------
S
S
S
S
E
---
I
E
----
E
M
V
E
R
A
T
E
I
A
G
L
G
E
K
I
K
D
R
V
S
T
Y
S
K
G
M
V
R
K
L
L
I
A
R
A
L
M
V
N
P
R
L
A
I
L
D
E
P
T
S
G
L
D
V
L
N
A
R
E
V
R
K
I
L
-
K
Q
A
S
Q
E
G
L
T
I
L
V
S
S
H
N
M
L
E
V
E
F
L
C
D
R
I
A
L
I
H
N
G
T
I
V
E
T
G
T
V
E
E
L
K
E
R
Y
---------
K
A
Q
N
I
E
E
V
F
E
E
V
V
K
------
11
PsiBlast_PDB
79.41
33%
-99
- C1 -
2OUK
1
?
A:
[24-246]
----
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
---
K
AKD
T
---
N
L
--
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
-
M
T
V
L
N
N
I
T
L
----
A
P
M
K
V
---
R
--
K
--
W
P
R
E
K
---
A
E
A
K
A
M
E
L
L
D
K
V
----
G
L
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
-
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
---------------------------------
9
PsiBlast_PDB
79.27
33%
-94
- C1 -
2OLJ
4
?
A:
[24-246]
----
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
---
K
AKD
T
---
N
L
--
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
-
M
T
V
L
N
N
I
T
L
----
A
P
M
K
V
---
R
--
K
--
W
P
R
E
K
---
A
E
A
K
A
M
E
L
L
D
K
V
----
G
L
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
-
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
---------------------------------
82
HHSearch
78.55
32%
-88
* C1 *
2OLJ
4
?
A:
[22-249]
--
L
Q
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
---
K
---
A
KDT
N
L
--
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
-
M
T
V
L
N
N
I
T
L
A
---
P
M
K
V
R
KWP
R
--
E
--
K
A
E
A
K
---
A
M
----
E
L
L
D
K
V
----
G
L
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
-
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
------------------------------
27
PsiBlast_CBE
78.50
33%
-93
- C1 -
2OUK
1
?
C:
[24-246]
----
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
---
K
AKD
T
---
N
L
--
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
-
M
T
V
L
N
N
I
T
L
----
A
P
M
K
V
---
R
--
K
--
W
P
R
E
K
---
A
E
AKAM
E
L
L
D
K
V
----
G
L
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
-
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
---------------------------------
31
PsiBlast_CBE
78.38
33%
-92
- C1 -
2OLK
2
?
B:
[24-246]
----
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
---
K
AKD
T
---
N
L
--
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
-
M
T
V
L
N
N
I
T
L
----
A
P
M
K
V
---
R
--
K
--
W
P
R
E
K
---
A
E
AKAM
E
L
L
D
K
V
----
G
L
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
-
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
---------------------------------
13
PsiBlast_PDB
78.34
33%
-94
- C1 -
3C4J
3
?
A:
[24-246]
----
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
---
K
AKD
T
---
N
L
--
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
-
M
T
V
L
N
N
I
T
L
----
A
P
M
K
V
---
R
--
K
--
W
P
R
E
K
---
A
E
A
K
A
M
E
L
L
D
K
V
----
G
L
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
-
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
---------------------------------
33
PsiBlast_CBE
77.86
31%
-92
- C1 -
4U02
1
?
D:
[2-225]
--
E
P
I
I
R
I
R
N
L
H
K
W
F
G
P
L
H
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
L
S
V
---
K
---
D
---
D
R
AL
R
E
I
R
R
E
V
G
M
V
F
Q
Q
F
N
L
F
P
H
-
M
T
V
L
E
N
V
T
L
----
A
P
M
R
V
---
R
--
R
--
W
P
R
E
K
---
A
E
KKAL
E
L
L
E
R
V
----
G
I
L
D
Q
A
R
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
-
R
D
L
A
Q
G
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
---------------------------------
30
PsiBlast_CBE
77.85
33%
-97
- C1 -
2OLK
1
?
C:
[24-246]
----
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
---
K
AKD
T
---
N
L
--
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
-
M
T
V
L
N
N
I
T
L
----
A
P
M
K
V
---
R
--
K
--
W
P
R
E
K
---
A
E
AKAM
E
L
L
D
K
V
----
G
L
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
-
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
---------------------------------
23
PsiBlast_CBE
77.76
33%
-98
- C1 -
3C41
3
?
K:
[3-225]
----
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
---
K
AKD
T
---
N
L
--
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
-
M
T
V
L
N
N
I
T
L
----
A
P
M
K
V
---
R
--
K
--
W
P
R
E
K
---
A
E
AKAM
E
L
L
D
K
V
----
G
L
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
-
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
---------------------------------
15
PsiBlast_PDB
77.71
31%
-90
- C1 -
4U02
1
?
A:
[2-225]
--
E
P
I
I
R
I
R
N
L
H
K
W
F
G
P
L
H
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
L
S
V
---
K
---
D
---
D
R
A
L
R
E
I
R
R
E
V
G
M
V
F
Q
Q
F
N
L
F
P
H
-
M
T
V
L
E
N
V
T
L
----
A
P
M
R
V
---
R
--
R
--
W
P
R
E
K
---
A
E
K
K
A
L
E
L
L
E
R
V
----
G
I
L
D
Q
A
R
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
-
R
D
L
A
Q
G
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
---------------------------------
29
PsiBlast_CBE
77.57
33%
-90
- C1 -
2OLK
1
?
D:
[24-246]
----
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
---
K
AKD
T
---
N
L
--
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
-
M
T
V
L
N
N
I
T
L
----
A
P
M
K
V
---
R
--
K
--
W
P
R
E
K
---
A
E
AKAM
E
L
L
D
K
V
----
G
L
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
-
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
---------------------------------
35
PsiBlast_CBE
77.51
31%
-91
- C1 -
4U02
1
?
B:
[2-225]
--
E
P
I
I
R
I
R
N
L
H
K
W
F
G
P
L
H
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
L
S
V
---
K
---
D
---
D
R
AL
R
E
I
R
R
E
V
G
M
V
F
Q
Q
F
N
L
F
P
H
-
M
T
V
L
E
N
V
T
L
----
A
P
M
R
V
---
R
--
R
--
W
P
R
E
K
---
A
E
KKAL
E
L
L
E
R
V
----
G
I
L
D
Q
A
R
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
-
R
D
L
A
Q
G
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
---------------------------------
24
PsiBlast_CBE
77.42
33%
-97
- C1 -
3C4J
4
?
B:
[24-246]
----
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
---
K
AKD
T
---
N
L
--
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
-
M
T
V
L
N
N
I
T
L
----
A
P
M
K
V
---
R
--
K
--
W
P
R
E
K
---
A
E
AKAM
E
L
L
D
K
V
----
G
L
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
-
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
---------------------------------
22
PsiBlast_CBE
77.41
34%
-91
- C1 -
4YMU
2
?
A:
[1-223]
----
M
I
F
V
N
D
V
Y
K
N
F
G
S
L
E
V
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
K
I
NNG
K
---
V
---
N
I
--
N
K
V
R
Q
K
V
G
M
V
F
Q
H
F
N
L
F
P
H
-
L
T
A
I
E
N
I
T
L
A
PVK
V
K
K
M
N
---
K
--
K
--
E
A
E
E
L
---
A
V
----
D
L
L
A
K
V
----
G
L
L
D
K
K
D
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
-
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
G
V
I
V
E
E
G
T
P
E
E
I
---------------------------------
37
PsiBlast_CBE
77.25
32%
-88
- C1 -
4P32
2
LPTB_ECOLI
B:
[3-223]
-----
L
T
A
K
N
L
A
K
A
Y
K
G
R
R
V
V
E
D
V
S
L
T
V
N
S
G
E
I
V
G
L
L
G
P
N
G
A
G
K
T
T
T
F
Y
M
V
V
G
I
V
P
R
D
A
G
N
I
I
I
D
D
D
D
I
---
S
---
L
---
L
P
LH
A
R
A
R
R
G
I
G
Y
L
P
Q
E
A
S
I
F
R
R
-
L
S
V
Y
D
N
L
M
A
V
---
L
Q
I
R
D
---
D
--
L
--
S
A
E
Q
R
EDR
A
N
----
E
L
M
E
E
F
----
H
I
E
H
L
R
D
S
M
G
Q
S
L
S
G
G
E
R
R
R
V
E
I
A
R
A
L
A
A
N
P
K
F
I
L
L
D
E
P
F
A
G
V
D
P
I
S
V
I
D
I
K
R
I
I
-
E
H
L
R
D
S
G
L
G
V
L
I
T
D
H
N
V
R
E
T
L
A
V
C
E
R
A
Y
I
V
S
Q
G
H
L
I
A
H
G
T
P
T
E
I
---------------------------------
8
PsiBlast_PDB
77.08
33%
-94
- C1 -
3C41
3
?
J:
[3-225]
----
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
---
K
AKD
T
---
N
L
--
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
-
M
T
V
L
N
N
I
T
L
----
A
P
M
K
V
---
R
--
K
--
W
P
R
E
K
---
A
E
AKAM
E
L
L
D
K
V
----
G
L
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
-
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
---------------------------------
14
PsiBlast_PDB
77.03
31%
-97
- C1 -
4U00
3
?
A:
[3-225]
---
P
I
I
R
I
R
N
L
H
K
W
F
G
P
L
H
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
L
S
V
---
K
---
D
---
D
R
A
L
R
E
I
R
R
E
V
G
M
V
F
Q
Q
F
N
L
F
P
H
-
M
T
V
L
E
N
V
T
L
----
A
P
M
R
V
---
R
--
R
--
W
P
R
E
K
---
A
E
K
K
A
L
E
L
L
E
R
V
----
G
I
L
D
Q
A
R
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
-
R
D
L
A
Q
G
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
---------------------------------
28
PsiBlast_CBE
77.02
33%
-95
- C1 -
2OUK
1
?
B:
[24-246]
----
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
---
K
AKD
T
---
N
L
--
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
-
M
T
V
L
N
N
I
T
L
----
A
P
M
K
V
---
R
--
K
--
W
P
R
E
K
---
A
E
A
K
A
M
E
L
L
D
K
V
----
G
L
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
-
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
---------------------------------
18
PsiBlast_PDB
76.79
32%
-86
- C1 -
4P33
7
LPTB_ECOLI
A:
[3-223]
-----
L
T
A
K
N
L
A
K
A
Y
K
G
R
R
V
V
E
D
V
S
L
T
V
N
S
G
E
I
V
G
L
L
G
P
N
G
A
G
K
T
T
T
F
Y
M
V
V
G
I
V
P
R
D
A
G
N
I
I
I
D
D
D
D
I
---
S
---
L
---
L
P
L
H
A
R
A
R
R
G
I
G
Y
L
P
Q
E
A
S
I
F
R
R
-
L
S
V
Y
D
N
L
M
A
V
---
L
Q
I
R
D
---
D
--
L
--
S
A
E
Q
R
E
D
R
A
N
----
E
L
M
E
E
F
----
H
I
E
H
L
R
D
S
M
G
Q
S
L
S
G
G
E
R
R
R
V
E
I
A
R
A
L
A
A
N
P
K
F
I
L
L
D
Q
P
F
A
G
V
D
P
I
S
V
I
D
I
K
R
I
I
-
E
H
L
R
D
S
G
L
G
V
L
I
T
D
H
N
V
R
E
T
L
A
V
C
E
R
A
Y
I
V
S
Q
G
H
L
I
A
H
G
T
P
T
E
I
---------------------------------
32
PsiBlast_CBE
76.34
33%
-93
- C1 -
2OLJ
3
?
B:
[24-246]
----
M
I
D
V
H
Q
L
K
K
S
F
G
S
L
E
V
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
N
L
---
K
AKD
T
---
N
L
--
N
K
V
R
E
E
V
G
M
V
F
Q
R
F
N
L
F
P
H
-
M
T
V
L
N
N
I
T
L
----
A
P
M
K
V
---
R
--
K
--
W
P
R
E
K
---
A
E
AKAM
E
L
L
D
K
V
----
G
L
K
D
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
-
K
Q
L
A
N
E
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
---------------------------------
17
PsiBlast_PDB
75.98
32%
-87
- C1 -
4P32
2
LPTB_ECOLI
A:
[3-223]
-----
L
T
A
K
N
L
A
K
A
Y
K
G
R
R
V
V
E
D
V
S
L
T
V
N
S
G
E
I
V
G
L
L
G
P
N
G
A
G
K
T
T
T
F
Y
M
V
V
G
I
V
P
R
D
A
G
N
I
I
I
D
D
D
D
I
---
S
---
L
---
L
P
L
H
A
R
A
R
R
G
I
G
Y
L
P
Q
E
A
S
I
F
R
R
-
L
S
V
Y
D
N
L
M
A
V
---
L
Q
I
R
D
---
D
--
L
--
S
A
E
Q
R
E
D
R
A
N
----
E
L
M
E
E
F
----
H
I
E
H
L
R
D
S
M
G
Q
S
L
S
G
G
E
R
R
R
V
E
I
A
R
A
L
A
A
N
P
K
F
I
L
L
D
E
P
F
A
G
V
D
P
I
S
V
I
D
I
K
R
I
I
-
E
H
L
R
D
S
G
L
G
V
L
I
T
D
H
N
V
R
E
T
L
A
V
C
E
R
A
Y
I
V
S
Q
G
H
L
I
A
H
G
T
P
T
E
I
---------------------------------
36
PsiBlast_CBE
75.51
32%
-79
- C1 -
4QC2
2
?
B:
[4-224]
-----
L
T
A
K
N
L
A
K
A
Y
K
G
R
R
V
V
E
D
V
S
L
T
V
N
S
G
E
I
V
G
L
L
G
P
N
G
A
G
K
T
T
T
F
Y
M
V
V
G
I
V
P
R
D
A
G
N
I
I
I
D
D
D
D
I
---
S
---
L
---
L
P
LH
A
R
A
R
R
G
I
G
Y
L
P
Q
E
A
S
I
F
R
R
-
L
S
V
Y
D
N
L
M
A
V
---
L
Q
I
R
D
---
D
--
L
--
S
A
E
Q
R
EDR
A
N
----
E
L
M
E
E
F
----
H
I
E
H
L
R
D
S
M
G
Q
S
L
S
G
G
E
R
R
R
V
E
I
A
R
A
L
A
A
N
P
K
F
I
L
L
D
E
P
F
A
G
V
D
P
I
S
V
I
D
I
K
R
I
I
-
E
H
L
R
D
S
G
L
G
V
L
I
T
D
H
N
V
R
E
T
L
A
V
C
E
R
A
Y
I
V
S
Q
G
H
L
I
A
H
G
T
P
T
E
I
---------------------------------
38
PsiBlast_CBE
75.50
32%
-84
- C1 -
4P33
6
LPTB_ECOLI
B:
[3-223]
-----
L
T
A
K
N
L
A
K
A
Y
K
G
R
R
V
V
E
D
V
S
L
T
V
N
S
G
E
I
V
G
L
L
G
P
N
G
A
G
K
T
T
T
F
Y
M
V
V
G
I
V
P
R
D
A
G
N
I
I
I
D
D
D
D
I
---
S
---
L
---
L
P
LH
A
R
A
R
R
G
I
G
Y
L
P
Q
E
A
S
I
F
R
R
-
L
S
V
Y
D
N
L
M
A
V
---
L
Q
I
R
D
---
D
--
L
--
S
A
E
Q
R
EDR
A
N
----
E
L
M
E
E
F
----
H
I
E
H
L
R
D
S
M
G
Q
S
L
S
G
G
E
R
R
R
V
E
I
A
R
A
L
A
A
N
P
K
F
I
L
L
D
Q
P
F
A
G
V
D
P
I
S
V
I
D
I
K
R
I
I
-
E
H
L
R
D
S
G
L
G
V
L
I
T
D
H
N
V
R
E
T
L
A
V
C
E
R
A
Y
I
V
S
Q
G
H
L
I
A
H
G
T
P
T
E
I
---------------------------------
16
PsiBlast_PDB
74.66
32%
-81
- C1 -
4QC2
2
?
A:
[4-224]
-----
L
T
A
K
N
L
A
K
A
Y
K
G
R
R
V
V
E
D
V
S
L
T
V
N
S
G
E
I
V
G
L
L
G
P
N
G
A
G
K
T
T
T
F
Y
M
V
V
G
I
V
P
R
D
A
G
N
I
I
I
D
D
D
D
I
---
S
---
L
---
L
P
L
H
A
R
A
R
R
G
I
G
Y
L
P
Q
E
A
S
I
F
R
R
-
L
S
V
Y
D
N
L
M
A
V
---
L
Q
I
R
D
---
D
--
L
--
S
A
E
Q
R
E
D
R
A
N
----
E
L
M
E
E
F
----
H
I
E
H
L
R
D
S
M
G
Q
S
L
S
G
G
E
R
R
R
V
E
I
A
R
A
L
A
A
N
P
K
F
I
L
L
D
E
P
F
A
G
V
D
P
I
S
V
I
D
I
K
R
I
I
-
E
H
L
R
D
S
G
L
G
V
L
I
T
D
H
N
V
R
E
T
L
A
V
C
E
R
A
Y
I
V
S
Q
G
H
L
I
A
H
G
T
P
T
E
I
---------------------------------
1
PsiBlast_PDB
63.20
48%
7
- C1 -
4YER
4
?
A:
[3-254]
--
E
D
I
I
V
V
E
N
L
V
K
K
F
G
D
F
E
A
V
K
G
V
S
F
S
V
K
K
G
E
I
F
A
F
L
G
P
N
G
A
G
K
T
T
T
I
H
M
L
T
T
L
L
K
P
T
S
G
K
A
W
V
A
G
H
D
V
---
L
---
K
---
E
P
--
R
E
V
R
R
K
I
G
I
V
F
Q
D
Q
S
L
D
R
E
-
L
T
A
Y
E
N
M
Y
I
H
---
G
K
I
Y
G
---
Y
G
G
E
--
K
L
K
K
R
---
I
L
----
E
L
L
E
F
V
----
E
L
L
E
F
K
D
K
P
V
K
T
F
S
G
G
M
A
R
R
L
E
I
A
R
S
L
I
H
E
P
E
V
L
F
L
D
E
P
T
I
G
L
D
P
H
T
R
A
H
M
W
E
Y
I
S
K
M
K
K
E
H
N
M
T
I
F
L
T
T
H
Y
M
D
E
A
E
Q
L
A
D
R
V
A
I
I
D
H
G
K
I
I
A
L
G
T
P
T
E
L
K
R
-------------------------------
60
PsiBlast_CBE
59.61
31%
-88
- C1 -
4HLU
3
ECFA1_THEMA
C:
[26-230]
-------------------
V
L
K
D
V
N
A
E
F
E
T
G
K
I
Y
V
V
V
G
K
N
G
S
G
K
T
T
L
L
K
I
L
A
G
L
L
A
A
-
A
G
E
I
F
L
D
G
--
S
---
P
---
A
---
D
P
--
F
L
L
R
K
N
V
G
Y
V
F
Q
N
P
S
S
Q
I
I
G
A
T
V
E
E
D
V
A
F
S
---
L
E
I
M
G
LD-
E
--
S
--
E
M
R
K
R
---
I
K
----
K
V
L
E
L
V
----
G
L
S
G
L
A
A
A
D
P
L
N
L
S
G
G
Q
K
Q
R
L
A
I
A
S
M
L
A
R
D
T
R
F
L
A
L
D
E
P
V
S
M
L
D
P
P
S
Q
R
E
I
F
Q
V
L
-
E
S
L
K
N
E
G
K
G
I
I
L
V
T
H
---
E
L
E
Y
L
D
D
M
D
F
I
L
H
----
I
S
N
G
T
I
D
-----
F
C
G
S
W
E
E
F
V
E
R
E
------------------
59
PsiBlast_CBE
59.37
31%
-89
- C1 -
4HLU
2
ECFA1_THEMA
D:
[26-230]
-------------------
V
L
K
D
V
N
A
E
F
E
T
G
K
I
Y
V
V
V
G
K
N
G
S
G
K
T
T
L
L
K
I
L
A
G
L
L
A
A
-
A
G
E
I
F
L
D
G
--
S
---
P
---
A
---
D
P
--
F
L
L
R
K
N
V
G
Y
V
F
Q
N
P
S
S
Q
I
I
G
A
T
V
E
E
D
V
A
F
S
---
L
E
I
M
G
LD-
E
--
S
--
E
M
R
K
R
---
I
K
----
K
V
L
E
L
V
----
G
L
S
G
L
A
A
A
D
P
L
N
L
S
G
G
Q
K
Q
R
L
A
I
A
S
M
L
A
R
D
T
R
F
L
A
L
D
E
P
V
S
M
L
D
P
P
S
Q
R
E
I
F
Q
V
L
-
E
S
L
K
N
E
G
K
G
I
I
L
V
T
H
---
E
L
E
Y
L
D
D
M
D
F
I
L
H
----
I
S
N
G
T
I
D
-----
F
C
G
S
W
E
E
F
V
E
R
E
------------------
20
PsiBlast_PDB
46.43
32%
4
- C1 -
4P31
2
LPTB_ECOLI
A:
[3-223]
-----
L
T
A
K
N
L
A
K
A
Y
K
G
R
R
V
V
E
D
V
S
L
T
V
N
S
G
E
I
V
G
L
L
G
P
N
G
A
G
K
T
T
T
F
Y
M
V
V
G
I
V
P
R
D
A
G
N
I
I
I
D
D
D
D
I
---
S
---
L
---
L
P
L
H
A
R
A
R
R
G
I
G
Y
L
P
Q
E
A
S
I
F
R
R
-
L
S
V
Y
D
N
L
M
A
V
---
L
Q
I
R
D
---
D
--
L
--
S
A
E
Q
R
E
D
R
A
N
----
E
L
M
E
E
F
----
H
I
E
H
L
R
D
S
M
G
Q
S
L
S
G
G
E
R
R
R
V
E
I
A
R
A
L
A
A
N
P
K
F
I
L
L
D
E
P
F
A
G
V
D
P
I
S
V
I
D
I
K
R
I
I
-
E
H
L
R
D
S
G
L
G
V
L
I
T
D
H
N
V
R
E
T
L
A
V
C
E
R
A
Y
I
V
S
Q
G
H
L
I
A
H
G
T
P
T
E
I
---------------------------------