@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1132: (2016-03-21 )
MSEWTIIGWLLKFVKPLRGKMILAILLGIISNLSVIMISLIGTYGIIAVILQQPLNPYKWLFVMVACGVVRGLARYLEQYLNHDIAFRLLAIIRERIFATLRKLGPARLSGKKSGDLVAAITTDVEALEVFFAHTISPVFIALGTTIATVGFLASYDVGLAIILLVGQIMVGVVLPMISYKRNKKIGTAYQQAFVGLNQMVMENIASLQDIFQFKLGEERLRKLETQGEKLNRQYKKRIRQGSELQILGEWVLIGTATIILVLGSLSQLPLETVLIGTVLSLSSFGSVLALNALGTALLTTFASGKRLYALTEEKPVVLFNGQLELSDFESAELDKVSFSHDGKQPLLNELSLALPKGKWLGIGGESGSGKSTLVKLLMRYWDPDGQVKLNNNELPKITESSLHRLEGVMEQRTFLFEDTLGNNIRLGKKDATLEEVKEAARKAAIDTWIETLPEGYETIIGGQSRNLSDGERQRIGLARLFLHDAPLLLLDEPTSNLDYINEQAILNTLRSEIQDKTVLVISHRATTLDLAEEQLFIENGALKRAAK
Atome Classification :
(43 SA)
-----------------------------------------------------------------.........10........20.........30.-..-.....40.-.-----..-..---------..50...----..-...--------60.........-------70........----80........90........100.......110.......120.......130.......140.......150.......160.......170.....-..180.-......190.......200.......210.......220.......230.-......240.-------......250-----.......260.-.....----..270.....-..----..280..-----.--------....290.......---..300...--....310-....----------.....320.--------..-----...--.330-..-...--....340..--.--.--.-...350.......360.......370.......380-.-.---.-....390.......400.......410.......420.......-430--.-.......440.......450.......460.......470.......480.......490.......500.......510..--.....520......-.530.......540......---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------------------------------------------------------MSE
W
T
I
I
G
W
L
L
K
F
V
K
P
LRG
K
-
M
I
L
A
I
L
L
G
I
IS
N
-
L
S
-
V
I
M
I
S
L
I
G
-
T
-----
Y
G
-
I
I
---------
A
V
I
L
QQP----L
N
-
P
Y
K
--------
W
-
L
F
V
M
V
A
C
G
V
-------
V
R
G
L
A
R
Y
L
E
Q
----
Y
L
N
H
D
I
A
F
R
L
L
A
I
I
R
E
R
I
F
A
T
L
R
KL
G
P
A
RLSGKKSG
D
L
V
A
A
ITT
D
V
E
A
L
E
V
F
F
A
HTI
S
P
V
F
I
ALG
T
T
I
A
T
V
G
F
L
A
S
Y
D
V
G
L
A
I
I
L
L
V
G
Q
I
M
V
G
V
V
L
P
M
-
I
SYKRN-KK
I
G
T
A
Y
Q
Q
A
F
V
G
L
N
Q
M
V
M
E
N
I
A
S
L
Q
D
I
F
Q
F
KL
G
E
E
R
L
R
K
L
E
TQ
G
E
K
L
N
R
-
Q
Y
K
K
R
IRQGS-------
E
L
Q
I
L
G
E
W
V
-----
L
I
G
T
A
T
I
I
L
-
V
-
L
G
S
L
S
----QL
P
--
L
E
T
V
L
-
I
G
----
T
V
L
S
L
S
S-----F--------
G
S
V
L
A
--
L
N
A
L
G
T
A
---
L
L
T
T
F
ASG--
K
R
L
Y
A
---LTEE----------K
P
V
V
L
FNG
Q
--------
L
E
-----LSD--FE---SA-EL
D
--
K
V
SFSH-DG--K--Q--
P
-
L
L
N
E
L
S
LALPKG
K
W
L
G
IGGESGS
G
K
S
T
L
V
K
L
L
M
R
YW-D-P---D-G
Q
V
K
LNNNELPKI
T
E
S
S
L
H
R
L
E
G
V
M
E
Q
R
T
F
L
F
EDTLGNNIRLGK-KD---A-
T
L
E
E
V
K
E
A
A
R
K
A
A
I
D
T
W
I
E
TLP
E
G
Y
E
T
I
IGGQSRNLSD
G
E
R
Q
R
I
G
L
A
R
L
F
LHDA
P
L
L
L
LDEPTSN
L
D
Y
I
N
E
Q
A
I
L
N
T
L
R
S
EI--QD
K
T
V
L
V
I
SHRAT
T
-
L
D
L
A
E
E
Q
L
F
IENGALKRAAK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
90.45
27%
-99
- C3 -
2ONJ
4
Y1866_STAAM
A:
[1-553]
----------------------------------------------------------------------
M
I
K
R
Y
L
Q
F
V
K
P
Y
K
Y
R
-
I
F
A
T
I
I
V
G
I
I
K
F
-
G
I
-
P
M
L
I
P
L
L
I
-
K
-----
Y
A
-
I
D
---------
G
V
I
N
N
H
A
----
L
T
T
D
E
K
--------
V
-
H
H
L
T
I
A
I
G
I
A
L
F
I
F
V
I
V
R
P
P
I
E
F
I
R
Q
----
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
--
I
F
P
F
Y
I
L
T
V
Y
V
F
F
G
R
L
-
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
D
K
K
N
T
N
F
L
T
-
R
A
L
K
H
T
R
W
N
A
Y
S
F
A
A
I
N
T
V
T
D
I
G
P
I
I
-----
V
I
G
V
G
A
Y
L
A
-
I
-
S
G
S
I
T
---------------
V
G
----
T
L
A
A
F
V
G
YLELL
F
--------
G
P
L
R
R
--
L
V
A
S
F
T
T
---
L
T
Q
S
F
A
S
M
--
D
R
V
F
Q
---
L
I
D
E
DYDIKNGVGA
Q
P
I
E
I
K
Q
G
R
--------
I
D
-----
I
--------------
D
--
H
V
S
F
Q
Y
N
D
N
--
E
--
A
--
P
-
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
-
D
V
T
---
S
-
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
L
G
R
-
P
T
---
A
-
T
D
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
S
--
K
D
R
T
T
L
I
V
A
H
R
L
S
T
-
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
89.50
27%
-99
- C3 -
2HYD
3
Y1866_STAAM
A:
[1-553]
----------------------------------------------------------------------
M
I
K
R
Y
L
Q
F
V
K
P
Y
K
Y
R
-
I
F
A
T
I
I
V
G
I
I
K
F
-
G
I
-
P
M
L
I
P
L
L
I
-
K
-----
Y
A
-
I
D
---------
G
V
I
N
N
H
A
----
L
T
T
D
E
K
--------
V
-
H
H
L
T
I
A
I
G
I
A
L
F
I
F
V
I
V
R
P
P
I
E
F
I
R
Q
----
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
--
I
F
P
F
Y
I
L
T
V
Y
V
F
F
G
R
L
-
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
D
K
K
N
T
N
F
L
T
-
R
A
L
K
H
T
R
W
N
A
Y
S
F
A
A
I
N
T
V
T
D
I
G
P
I
I
-----
V
I
G
V
G
A
Y
L
A
-
I
-
S
G
S
I
T
---------------
V
G
----
T
L
A
A
F
V
G
YLELL
F
--------
G
P
L
R
R
--
L
V
A
S
F
T
T
---
L
T
Q
S
F
A
S
M
--
D
R
V
F
Q
---
L
I
D
E
DYDIKNGVGA
Q
P
I
E
I
K
Q
G
R
--------
I
D
-----
I
--------------
D
--
H
V
S
F
Q
Y
N
D
N
--
E
--
A
--
P
-
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
-
D
V
T
---
S
-
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
L
G
R
-
P
T
---
A
-
T
D
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
S
--
K
D
R
T
T
L
I
V
A
H
R
L
S
T
-
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
88.25
27%
-93
- C3 -
3QF4
1
Y288_THEMA
B:
[28-572]
--------------------------------------------------------------------------
L
L
G
Y
L
R
P
H
T
F
T
-
L
I
M
V
F
V
F
V
T
V
S
S
I
L
G
-
V
L
S
P
Y
L
I
G
K
T
-----
I
D
-
V
V
---------
F
V
P
R
R
F
D
----
L
L
-
P
-
R
--------
Y
-
M
L
I
L
G
T
I
Y
A
-------
L
T
S
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
----
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
-
S
I
V
P
L
T
V
L
I
T
Q
-
I
V
S
S
Q
T
-
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
-
V
-------
G
T
-------
K
A
Q
I
F
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
F
A
L
-
I
-
S
G
F
G
G
----
W
L
A
--
L
K
D
I
I
T
V
G
----
T
I
A
T
F
I
G
-----
Y
--------
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
--
E
R
I
F
E
I
L
D
L
E
E
E
----------
K
D
D
---
P
D
A
--------
V
E
-----
L
R
E
--
V
R
---
G
E
I
E
F
K
--
N
V
W
F
S
Y
-
D
K
--
K
--
K
--
P
-
V
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
-
D
-
V
---
D
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
G
N
-
P
G
---
A
-
T
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
--
E
G
K
T
S
I
I
I
A
H
R
L
N
T
-
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
86.30
27%
-96
- C3 -
4Q4A
1
Y288_THEMA
B:
[28-572]
--------------------------------------------------------------------------
L
L
G
Y
L
R
P
H
T
F
T
-
L
I
M
V
F
V
F
V
T
V
S
S
I
L
G
-
V
L
S
P
Y
L
I
G
K
T
-----
I
D
-
V
V
---------
F
V
P
R
R
F
D
----
L
L
-
P
-
R
--------
Y
-
M
L
I
L
G
T
I
Y
A
-------
L
T
S
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
----
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
-
S
I
V
P
L
T
V
L
I
T
Q
-
I
V
S
S
Q
T
-
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
-
V
-------
G
T
-------
K
A
Q
I
F
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
F
A
L
-
I
-
S
G
F
G
G
----
W
L
A
--
L
K
D
I
I
T
V
G
----
T
I
A
T
F
I
G
-----
Y
--------
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
--
E
R
I
F
E
I
L
D
L
E
E
E
----------
K
D
D
---
P
D
A
--------
V
E
-----
L
R
E
--
V
R
---
G
E
I
E
F
K
--
N
V
W
F
S
Y
-
D
K
--
K
--
K
--
P
-
V
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
-
D
-
V
---
D
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
G
N
-
P
G
---
A
-
T
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
--
E
G
K
T
S
I
I
I
A
H
R
L
N
T
-
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
84.88
27%
-85
- C3 -
3B60
2
MSBA_SALTY
A:
[10-554]
--------------------------------------------------------------------
W
Q
T
F
R
R
L
W
P
T
I
A
P
F
K
A
G
-
L
I
V
A
G
I
A
L
I
L
N
A
-
A
S
D
T
F
M
L
S
L
L
K
-
P
LLDDG
F
G
-
K
T
DR-------
S
V
L
L
W
M
P
----
L
-----------------
V
V
I
G
L
M
I
-------
L
R
G
I
T
S
Y
I
S
S
----
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
-
V
S
-
K
R
F
-
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
-
Q
G
M
K
M
V
S
A
S
S
-------
I
S
D
P
I
I
Q
-------
L
I
A
S
L
A
L
A
F
-
V
-
L
Y
A
A
S
-----
F
P
SV
M
D
S
L
T
-
A
G
----
T
I
T
V
V
-------
F
--------
S
S
M
I
A
--
L
M
R
P
L
K
S
---
L
T
N
V
N
A
Q
F
--
Q
R
G
M
A
---
A
C
Q
T
----------
L
F
A
I
L
D
S
E
Q
--------
E
K
D
E
G
K
R
V
I
D
--
R
A
---
T
G
-
D
L
E
F
R
N
V
T
F
T
Y
-
P
G
--
R
--
E
V-
P
-
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
-
D
-
I
---
D
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
R
T
E
E
---
Y
-
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
--
K
N
R
T
S
L
V
I
A
H
R
L
S
T
-
I
E
Q
A
D
E
I
V
V
V
E
D
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
84.74
27%
-93
- C3 -
4Q4H
-
Y288_THEMA
B:
[28-572]
--------------------------------------------------------------------------
L
L
G
Y
L
R
P
H
T
F
T
-
L
I
M
V
F
V
F
V
T
V
S
S
I
L
G
-
V
L
S
P
Y
L
I
G
K
T
-----
I
D
-
V
V
---------
F
V
P
R
R
F
D
----
L
L
-
P
-
R
--------
Y
-
M
L
I
L
G
T
I
Y
A
-------
L
T
S
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
----
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
-
S
I
V
P
L
T
V
L
I
T
Q
-
I
V
S
S
Q
T
-
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
-
V
-------
G
T
-------
K
A
Q
I
F
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
F
A
L
-
I
-
S
G
F
G
G
----
W
L
A
--
L
K
D
I
I
T
V
G
----
T
I
A
T
F
I
G
-----
Y
--------
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
--
E
R
I
F
E
I
L
D
L
E
E
E
----------
K
D
D
---
P
D
A
--------
V
E
-----
L
R
E
--
V
R
---
G
E
I
E
F
K
--
N
V
W
F
S
Y
-
D
K
--
K
--
K
--
P
-
V
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
-
D
-
V
---
D
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
G
N
-
P
G
---
A
-
T
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
--
E
G
K
T
S
I
I
I
A
H
R
L
N
T
-
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
83.58
26%
-85
- C3 -
4AYT
8
ABCBA_HUMAN
A:
[10-564]
--------------------------------------------------------------------------
L
L
G
L
A
Y
P
E
R
R
R
-
L
A
A
A
V
--
G
F
L
T
M
-
S
S
-
V
I
S
M
S
A
P
F
-
F
-----
L
G
K
I
I
---------
D
V
I
Y
T
N
P
----
T
V
-
D
Y
S
D
N
L
T
R
L
C
L
G
-
L
S
A
V
F
L
C
G
A
-------
A
---
A
N
A
I
R
V
----
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
A
--
G
A
Q
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
I
I
A
-
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
--
G
K
E
-
M
T
E
I
E
K
Y
A
S
K
V
D
H
------
V
M
Q
L
A
-------
R
K
E
A
F
A
R
A
G
-----
F
F
G
A
T
G
L
S
G
-
N
-
L
I
V
L
S
----
V
L
Y
--
K
G
G
L
L
-
M
G
S
AHM
T
V
G
E
L
S
S
-----
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
--
L
S
S
F
Y
S
E
---
L
M
K
G
L
G
A
G
--
G
R
L
W
E
---
L
L
E
R
----------
E
P
K
L
P
F
N
E
G
--------
V
I
-----
L
N
E
KS
F
Q
---
G
A
L
E
F
K
--
N
V
H
F
A
Y
-
P
A
--
R
--
P
EV
P
-
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
-
D
-
P
A--
S
-
G
T
I
S
L
D
G
H
D
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
G
A
-
D
D
PSS
V
-
T
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
--
D
G
R
T
V
L
V
I
A
H
R
L
S
T
-
I
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
83.56
26%
-88
- C3 -
4AYX
7
ABCBA_HUMAN
A:
[10-564]
--------------------------------------------------------------------------
L
L
G
L
A
Y
P
E
R
R
R
-
L
A
A
A
V
--
G
F
L
T
M
-
S
S
-
V
I
S
M
S
A
P
F
-
F
-----
L
G
K
I
I
---------
D
V
I
Y
T
N
P
----
T
V
-
D
Y
S
D
N
L
T
R
L
C
L
G
-
L
S
A
V
F
L
C
G
A
-------
A
---
A
N
A
I
R
V
----
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
A
--
G
A
Q
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
I
I
A
-
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
--
G
K
E
-
M
T
E
I
E
K
Y
A
S
K
V
D
H
------
V
M
Q
L
A
-------
R
K
E
A
F
A
R
A
G
-----
F
F
G
A
T
G
L
S
G
-
N
-
L
I
V
L
S
----
V
L
Y
--
K
G
G
L
L
-
M
G
S
AHM
T
V
G
E
L
S
S
-----
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
--
L
S
S
F
Y
S
E
---
L
M
K
G
L
G
A
G
--
G
R
L
W
E
---
L
L
E
R
----------
E
P
K
L
P
F
N
E
G
--------
V
I
-----
L
N
E
KS
F
Q
---
G
A
L
E
F
K
--
N
V
H
F
A
Y
-
P
A
--
R
--
P
EV
P
-
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
-
D
-
P
A--
S
-
G
T
I
S
L
D
G
H
D
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
G
A
-
D
D
PSS
V
-
T
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
--
D
G
R
T
V
L
V
I
A
H
R
L
S
T
-
I
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
83.50
26%
-91
- C3 -
4Q4J
-
Y288_THEMA
B:
[28-572]
--------------------------------------------------------------------------
L
L
G
Y
L
R
P
H
T
F
T
-
L
I
M
V
F
V
F
V
T
V
S
S
I
L
G
-
V
L
S
P
Y
L
I
G
K
T
-----
I
D
-
V
V
---------
F
V
P
R
R
F
D
----
L
L
-
P
-
R
--------
Y
-
M
L
I
L
G
T
I
Y
A
-------
L
T
S
L
L
F
W
L
Q
G
K
I
M
L
T
L
S
Q
D
V
V
F
R
L
----
R
K
E
L
F
E
K
L
Q
R
V
P
V
G
F
F
D
R
T
P
H
G
D
I
I
S
R
V
I
N
D
V
D
N
I
N
N
V
L
G
N
S
I
I
Q
F
F
S
G
I
V
T
L
A
G
A
V
I
M
M
F
R
V
N
V
I
L
S
L
V
T
L
-
S
I
V
P
L
T
V
L
I
T
Q
-
I
V
S
S
Q
T
-
R
K
Y
F
Y
E
N
Q
R
V
L
G
Q
L
N
G
I
I
E
E
D
I
S
G
L
T
V
I
K
L
F
T
R
E
E
K
E
M
E
K
F
D
R
V
N
E
S
L
R
K
-
V
-------
G
T
-------
K
A
Q
I
F
S
G
V
L
P
P
L
M
N
M
V
N
N
L
G
F
A
L
-
I
-
S
G
F
G
G
----
W
L
A
--
L
K
D
I
I
T
V
G
----
T
I
A
T
F
I
G
-----
Y
--------
S
R
Q
F
T
R
P
L
N
E
L
S
N
Q
F
N
M
I
Q
M
A
L
A
S
A
--
E
R
I
F
E
I
L
D
L
E
E
E
----------
K
D
D
---
P
D
A
--------
V
E
-----
L
R
E
--
V
R
---
G
E
I
E
F
K
--
N
V
W
F
S
Y
-
D
K
--
K
--
K
--
P
-
V
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
-
D
-
V
---
D
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
G
N
-
P
G
---
A
-
T
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
C
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
--
E
G
K
T
S
I
I
I
A
H
R
L
N
T
-
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
80.43
26%
-86
- C3 -
3ZDQ
6
ABCBA_HUMAN
A:
[10-564]
--------------------------------------------------------------------------
L
L
G
L
A
Y
P
E
R
R
R
-
L
A
A
A
V
--
G
F
L
T
M
-
S
S
-
V
I
S
M
S
A
P
F
-
F
-----
L
G
K
I
I
---------
D
V
I
Y
T
N
P
----
T
V
-
D
Y
S
D
N
L
T
R
L
C
L
G
-
L
S
A
V
F
L
C
G
A
-------
A
---
A
N
A
I
R
V
----
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
A
--
G
A
Q
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
P
V
S
I
I
A
-
V
I
Y
G
R
Y
L
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
--
G
K
E
-
M
T
E
I
E
K
Y
A
S
K
V
D
H
------
V
M
Q
L
A
-------
R
K
E
A
F
A
R
A
G
-----
F
F
G
A
T
G
L
S
G
-
N
-
L
I
V
L
S
----
V
L
Y
--
K
G
G
L
L
-
M
G
S
AHM
T
V
G
E
L
S
S
-----
F
L
M
Y
A
F
W
V
G
I
S
I
G
G
--
L
S
S
F
Y
S
E
---
L
M
K
G
L
G
A
G
--
G
R
L
W
E
---
L
L
E
R
----------
E
P
K
L
P
F
N
E
G
--------
V
I
-----
L
N
E
KS
F
Q
---
G
A
L
E
F
K
--
N
V
H
F
A
Y
-
P
A
--
R
--
P
EV
P
-
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
-
D
-
P
A--
S
-
G
T
I
S
L
D
G
H
D
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
G
A
-
D
D
PSS
V
-
T
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
--
D
G
R
T
V
L
V
I
A
H
R
L
S
T
-
I
K
N
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
HHSearch
78.49
24%
-77
- C3 -
3B60
2
MSBA_SALTY
A:
[10-560]
--------------------------------------------------------------------
W
Q
T
F
R
R
L
W
P
T
I
A
P
F
K
A
G
-
L
I
V
A
G
I
A
L
I
L
N
A
-
A
S
-
D
T
F
M
L
S
L
L
-
K
-----
P
L
-
L
D
---------
D
G
F
G
K
T
D
----
R
S
V
L
L
W
--------
M
-
P
L
V
V
I
G
L
M
I
-------
L
R
G
I
T
S
Y
I
S
S
----
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
-
V
S
I
A
I
R
-
V
V
S
K
R
F
-
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
-
Q
G
M
K
M
V
S
A
S
S
-------
I
S
D
P
I
I
Q
L
I
-----
A
S
L
A
L
A
F
V
L
Y
A
-
A
S
F
P
S
VMD-
S
L
T
--
A
G
T
I
T
-
V
V
----
F
S
S
M
I
A
L
-----
M
--------
R
P
L
K
S
--
L
T
N
V
N
A
Q
---
F
Q
R
G
M
A
A
C
--
Q
T
L
F
A
---
I
L
D
S
----------
E
Q
E
K
D
E
G
K
R
--------
V
I
-----
D
R
A
--
T
G
---
D
L
-
E
F
R
--
N
V
T
F
T
Y
-
P
G
R-
E
--
V
--
P
-
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
-
D
-
I
---
D
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
R
-
T
E
E--
Y
-
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
--
K
N
R
T
S
L
V
I
A
H
R
L
S
T
-
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
Fugue
78.36
24%
-79
- C3 -
3B60
2
MSBA_SALTY
A:
[10-581]
--------------------------------------------------------------------
W
Q
T
F
R
R
L
W
P
T
I
A
P
F
K
A
G
-
L
I
V
A
G
I
A
L
I
L
N
A
-
A
S
-
D
T
F
M
L
S
L
L
-
K
-----
P
L
-
L
D
---------
D
G
F
G
K
T
D
----
R
S
-
V
L
L
--------
W
M
P
L
V
V
I
G
L
M
I
-------
L
R
G
I
T
S
Y
I
S
S
----
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
-
V
S
-
K
R
F
-
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
-
Q
G
M
K
M
V
S
A
S
S
-------
I
S
D
P
I
I
Q
L
I
-----
A
S
L
A
L
A
F
V
L
-
Y
-
A
A
S
F
P
SVMD
S
L
T
--
A
G
T
I
T
-
V
V
----
F
S
S
M
I
A
L
-----
M
--------
R
P
L
K
S
--
L
T
N
V
N
A
Q
---
F
Q
R
G
M
A
A
C
--
Q
T
L
F
A
---
I
L
D
S
----------
E
Q
E
K
D
E
G
K
R
--------
V
I
-----
D
R
A
--
T
G
---
D
L
-
E
F
R
--
N
V
T
F
T
Y
-
P
G
--
R
E-
V
--
P
-
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
-
D
-
I
---
D
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
R
-
T
E
---
E
Y
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
--
K
N
R
T
S
L
V
I
A
H
R
L
S
T
-
I
E
Q
A
D
E
I
V
V
V
E
D
G
I
I
V
E
R
G
T
H
S
E
L
L
A
Q
HG
V
Y
A
Q
L
H
K
M
QFG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
HHSearch
77.06
23%
-82
- C3 -
3ZDQ
6
ABCBA_HUMAN
A:
[3-563]
-------------------------------------------------------------------
G
L
P
E
A
R
K
L
L
G
L
A
Y
P
E
R
R
R
-
L
A
A
A
V
G
F
L
T
M
S
S
-
V
I
-
S
M
S
A
P
F
F
L
-
G
-----
K
I
-
I
D
---------
V
I
Y
T
N
P
T
VDY
S
D
N
-
L
T
R
--------
L
-
C
L
G
L
S
A
V
F
L
-------
C
G
A
A
A
N
A
I
R
V
----
Y
L
M
Q
T
S
G
Q
R
I
V
N
R
L
R
T
S
L
F
S
S
I
L
R
Q
E
V
A
F
F
D
K
T
R
T
G
E
L
I
N
R
L
S
S
D
T
A
L
L
G
R
S
V
T
E
N
L
S
D
G
L
R
A
G
A
Q
A
S
V
G
I
S
M
M
F
F
V
S
P
N
L
A
T
F
V
L
S
V
V
P
-
P
V
S
I
I
A
V
-
I
Y
G
R
Y
L
-
R
K
L
T
K
V
T
Q
D
S
L
A
Q
A
T
Q
L
A
E
E
R
I
G
N
V
R
T
V
R
A
F
G
K
E
M
T
E
I
E
K
Y
A
S
K
V
D
H
V
M
Q
-
L
A
R
K
E
A
F
A
R
A
-------
G
F
F
G
A
T
G
L
S
-----
G
N
L
I
V
L
S
V
L
Y
K
-
G
G
L
L
M
G
S
A-
H
M
T
--
V
G
E
L
S
-
S
F
----
L
M
Y
A
F
W
V
-----
G
--------
I
S
I
G
G
--
L
S
S
F
Y
S
E
---
L
M
K
G
L
G
A
G
--
G
R
L
W
E
---
L
L
E
R
----------
E
P
K
L
P
F
N
E
G
V
I
L
-----
N
E
-----
K
S
F
--
Q
G
---
A
L
-
E
F
K
--
N
V
H
F
A
Y
-
P
A
RP
E
--
V
--
P
-
I
F
Q
D
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
-
D
-
P
---
A
S
G
T
I
S
L
D
G
H
D
I
R
Q
L
N
P
V
W
L
R
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
G
A
-
D
D
PSS
V
-
T
A
E
E
I
Q
R
V
A
E
V
A
N
A
V
A
F
I
R
N
F
P
Q
G
F
N
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
E
A
L
D
R
L
M
--
D
G
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
-
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
HHSearch
75.83
22%
-93
- C3 -
3WMG
6
?
A:
[14-574]
-----------------------------------------------------------------------
A
R
R
I
F
A
L
A
W
S
S
S
A
T
M
I
V
I
G
F
I
A
S
I
L
E
G
-
A
T
-
L
P
A
F
A
I
V
F
-
G
-----
R
M
-
F
Q
---------
V
F
T
K
S
K
S
Q
I
E
-
G
E
-
T
W
K
--------
Y
-
S
V
G
F
V
G
I
G
V
-------
F
E
F
I
V
A
G
S
R
T
----
A
L
F
G
I
A
S
E
R
L
A
R
D
L
R
V
A
A
F
S
N
L
V
E
Q
D
V
T
Y
F
D
R
R
K
A
G
E
L
G
G
K
L
N
N
D
V
Q
V
I
Q
Y
S
F
S
K
-
L
G
A
V
L
F
N
L
A
Q
C
V
V
G
I
I
V
A
F
I
F
A
P
A
L
T
G
V
L
I
A
L
S
P
L
V
V
-
L
A
V
V
-
V
Q
M
I
E
M
-
S
G
N
T
K
R
S
S
E
A
Y
A
S
A
G
S
V
A
A
E
V
F
S
N
I
R
T
T
K
A
F
E
A
E
R
Y
E
T
Q
R
Y
G
S
K
L
D
P
L
Y
R
-
L
G
R
R
R
Y
I
S
D
G
-------
L
F
F
G
L
S
M
L
V
-----
I
F
C
V
Y
A
L
A
L
W
W
-
G
G
Q
L
I
A
R
G-
S
L
N
--
L
G
N
L
L
-
T
A
----
F
F
S
A
I
L
G
-----
F
--------
M
G
V
G
Q
--
A
A
Q
V
W
P
D
---
V
T
R
G
L
G
A
G
--
G
E
L
F
A
---
M
I
D
R
----------
V
P
Q
Y
R
R
P
D
P
G
A
E
V
V
T--
Q
P
-----
L
V
L
--
K
Q
---
G
I
-
V
F
E
--
N
V
H
F
R
Y
-
P
T
--
R
MN
V
--
E
-
V
L
R
G
I
S
L
T
I
P
N
G
K
T
V
A
I
V
G
G
S
G
A
G
K
S
T
I
I
Q
L
L
M
R
F
Y
-
D
-
I
EPQ
G
G
G
L
L
L
F
D
G
T
P
A
W
N
Y
D
F
H
A
L
R
S
Q
I
G
L
V
S
Q
E
P
V
L
F
S
G
T
I
R
D
N
I
L
Y
G
K
-
R
D
---
A
-
T
D
E
E
V
I
Q
A
L
R
E
A
N
A
Y
S
F
V
M
A
L
P
D
G
L
D
T
E
V
G
E
R
G
L
A
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
I
L
K
H
P
T
L
L
C
L
D
E
S
T
S
A
L
D
A
E
S
E
A
L
V
Q
E
A
L
D
R
M
M
A
S
D
G
V
T
S
V
V
I
A
H
R
L
S
T
V
A
R
-
A
D
L
I
L
V
M
Q
D
G
V
V
V
E
Q
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
74.28
27%
-98
- C3 -
4A82
-
Y1866_STAAM
A:
[1-553]
----------------------------------------------------------------------
M
I
K
R
Y
L
Q
F
V
K
P
Y
K
Y
R
-
I
F
A
T
I
I
V
G
I
I
K
F
-
G
I
-
P
M
L
I
P
L
L
I
-
K
-----
Y
A
-
I
D
---------
G
V
I
N
N
H
A
----
L
T
T
D
E
K
--------
V
-
H
H
L
T
I
A
I
G
I
A
L
F
I
F
V
I
V
R
P
P
I
E
F
I
R
Q
----
Y
L
A
Q
W
T
S
N
K
I
L
Y
D
I
R
K
K
L
Y
N
H
L
Q
A
L
S
A
R
F
Y
A
N
N
Q
V
G
Q
V
I
S
R
V
I
N
D
V
E
Q
T
K
D
F
I
L
T
G
L
M
N
I
W
L
D
C
I
T
I
I
I
A
L
S
I
M
F
F
L
D
V
K
L
T
L
A
A
L
F
--
I
F
P
F
Y
I
L
T
V
Y
V
F
F
G
R
L
-
R
K
L
T
R
E
R
S
Q
A
L
A
E
V
Q
G
F
L
H
E
R
V
Q
G
I
S
V
V
K
S
F
A
I
E
D
N
E
A
K
N
F
D
K
K
N
T
N
F
L
T
-
R
A
L
K
H
T
R
W
N
A
Y
S
F
A
A
I
N
T
V
T
D
I
G
P
I
I
-----
V
I
G
V
G
A
Y
L
A
-
I
-
S
G
S
I
T
---------------
V
G
----
T
L
A
A
F
V
G
YLELL
F
--------
G
P
L
R
R
--
L
V
A
S
F
T
T
---
L
T
Q
S
F
A
S
M
--
D
R
V
F
Q
---
L
I
D
E
DYDIKNGVGA
Q
P
I
E
I
K
Q
G
R
--------
I
D
-----
I
--------------
D
--
H
V
S
F
Q
Y
N
D
N
--
E
--
A
--
P
-
I
L
K
D
I
N
L
S
I
E
K
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
Y
-
D
V
T
---
S
-
G
Q
I
L
I
D
G
H
N
I
K
D
F
L
T
G
S
L
R
N
Q
I
G
L
V
Q
Q
D
N
I
L
F
S
D
T
V
K
E
N
I
L
L
G
R
-
P
T
---
A
-
T
D
E
E
V
V
E
A
A
K
M
A
N
A
H
D
F
I
M
N
L
P
Q
G
Y
D
T
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
S
--
K
D
R
T
T
L
I
V
A
H
R
L
S
T
-
I
T
H
A
D
K
I
V
V
I
E
N
G
H
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
Fugue
74.23
22%
-91
- C3 -
4F4C
3
PGP1_CAEEL
A:
[4-1306]
N
G
S
L
R
Q
S
L
R
T
L
D
S
F
SLA
P
E
D
V
L
K
T
A
I
K
T
V
E
D
Y
EGDNIDSNG
E
I
K
I
TRDEVV
N
K
V
S
I
P
Q
L
Y
RYTT
T
L
E
K
L
L
L
F
I
G
T
L
V
A
V
I
T
G
A
G
L
-
P
L
M
S
I
L
Q
G
K
V
S
Q
-
A
F
-
I
N
E
Q
I
V
I
N
-
N
-----
N
G
-
S
T
F
LPTGQNYT
K
T
D
F
E
H
D
----
V
M
-
N
V
V
--------
W
-
S
Y
A
A
M
T
V
G
M
-------
W
A
A
G
Q
I
T
V
T
C
----
Y
L
Y
--
V
A
E
Q
M
N
N
R
L
R
R
E
F
V
K
S
I
L
R
Q
E
I
S
W
F
D
T
N
H
S
G
T
L
A
T
K
L
F
D
N
L
E
R
V
K
E
G
T
G
D
K
I
G
M
A
F
Q
Y
L
S
Q
F
I
T
G
F
I
V
A
F
T
H
S
W
Q
L
T
L
V
M
L
A
V
T
P
I
Q
A
L
C
G
F
A
-
I
A
-
K
S
M
-
S
T
F
A
I
R
E
T
L
R
Y
A
K
A
G
K
V
V
E
E
T
I
S
S
I
R
T
V
V
S
L
N
G
L
R
Y
E
L
E
R
Y
S
T
A
V
E
E
A
K
K
A
G
V
L
K
G
L
F
L
G
I
-------
S
F
G
A
M
Q
A
S
N
-----
F
I
S
F
A
L
A
F
Y
-
I
G
V
G
W
V
H
----
D
G
S
--
L
N
F
G
D
-
M
L
----
T
T
F
S
S
V
M
-----
M
--------
G
S
M
A
L
--
G
L
A
G
P
Q
L
---
A
V
L
G
T
A
Q
G
A
A
S
G
I
Y
E
---
V
L
D
R
----------
K
P
V
I
D
S
S
S
K
--------
A
G
-----
R
K
D
--
M
K
IK
G
D
I
-
T
V
E
--
N
V
H
F
T
Y
-
P
S
--
R
--
P
DV
P
-
I
L
R
G
M
N
L
R
V
N
A
G
Q
T
V
A
L
V
G
S
S
G
C
G
K
S
T
I
I
S
L
L
L
R
Y
Y
-
D
-
V
L--
K
-
G
K
I
T
I
D
G
V
D
V
R
D
I
N
L
E
F
L
R
K
N
V
A
V
V
S
Q
E
P
A
L
F
N
C
T
I
E
E
N
I
S
L
G
K
-
E
G
---
I
-
T
R
E
E
M
V
A
A
C
K
M
A
N
A
E
K
F
I
K
T
L
P
N
G
Y
N
T
L
V
G
D
R
G
T
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
S
E
G
I
V
Q
Q
A
L
D
K
A
A
--
K
G
R
T
T
I
I
I
A
H
R
L
S
T
-
I
R
N
A
D
L
I
I
S
C
K
N
G
Q
V
V
E
V
G
D
H
R
A
L
M
A
Q
QG
L
Y
Y
D
L
V
T
A
Q
T
F
T
D
A
V
D
S
A
A
E
GER
I
G
K
D
A
L
S
R
L
K
Q
E
L
E
ENNAQKTN
L
F
E
I
L
Y
H
A
RPH
A
L
S
L
F
I
G
M
S
T
A
T
I
G
G
F
I
Y
P
T
Y
S
V
F
F
T
S
F
M
N
V
F
AGNPADFL
S
Q
G
H
F
W
A
L
M
F
L
V
L
A
A
A
Q
G
I
C
S
F
L
M
T
F
F
M
G
I
A
S
E
S
L
T
R
D
L
R
N
K
L
F
R
N
V
L
S
QHIGFFDSPQNA
S
G
K
I
S
T
R
L
A
T
D
V
P
N
L
R
T
A
I
D
F
R
F
S
T
V
I
T
T
L
V
S
M
V
A
G
I
G
L
A
F
F
Y
G
W
Q
M
A
L
L
I
I
A
I
L
P
I
V
A
F
G
Q
Y
L
R
G
RRFTGKNVKSA
S
E
F
A
D
S
G
K
I
A
I
E
A
I
E
N
V
R
T
V
Q
A
L
AR
E
D
T
F
Y
E
N
F
C
E
K
L
D
I
P
H
K
E
A
I
K
E
A
F
I
Q
G
L
S
Y
G
C
A
S
S
V
L
Y
L
L
N
T
C
A
Y
R
M
G
L
A
L
I
I
TDPPTMQ
P
M
R
V
L
R
V
M
Y
A
I
T
I
S
T
S
TLGFAT
S
Y
F
P
E
Y
A
K
A
T
F
A
G
G
I
I
F
G
M
L
R
KISKIDSLSLAGEKKKLYGK
V
I
F
K
N
V
R
F
A
Y
PERPEIEILK
G
L
S
F
S
V
E
PG
Q
T
L
A
L
V
G
P
S
GCGKST
V
V
A
L
L
E
RFYDTL
G
G
E
I
F
I
DGSEIKTLN
P
E
H
T
R
S
Q
I
A
I
V
S
Q
E
P
T
L
F
DCS
I
A
E
N
I
I
YGLDPSSVT
M
A
Q
V
E
E
A
A
R
L
A
NI
H
N
F
I
A
E
LPEGFETRVGDRGTQLS
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
NPK
I
L
L
L
D
EATSALDT
E
S
E
K
V
V
Q
E
A
L
D
R
A
R
EG
R
T
C
I
V
I
A
HRLNTVMNAD
C
I
A
V
V
S
NGTII
E
K
G
T
H
T
Q
L
M
S
E
K
9
PsiBlast_PDB
63.51
27%
42
- C- -
3B5Y
2
MSBA_SALTY
A:
[10-554]
--------------------------------------------------------------------
W
Q
T
F
R
R
L
W
P
T
I
A
P
F
K
A
G
-
L
I
V
A
G
I
A
L
I
L
N
A
-
A
S
D
T
F
M
L
S
L
L
K
-
P
L
L
DDG
F
G
-
K
T
DR-------
S
V
L
L
W
M
P
----
L
-----------------
V
V
I
G
L
M
I
-------
L
R
G
I
T
S
Y
I
S
S
----
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
-
V
S
-
K
R
F
-
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
-
Q
G
M
K
M
V
S
A
S
S
-------
I
S
D
P
I
I
Q
-------
L
I
A
S
L
A
L
A
F
-
V
-
L
Y
A
A
S
-----
F
P
SV
M
D
S
L
T
-
A
G
----
T
I
T
V
V
-------
F
--------
S
S
M
I
A
--
L
M
R
P
L
K
S
---
L
T
N
V
N
A
Q
F
--
Q
R
G
M
A
---
A
C
Q
T
----------
L
F
A
I
L
D
S
E
Q
--------
E
K
DEGKR
V
I
D
--
R
A
---
T
G
-
D
L
E
F
R
N
V
T
F
T
Y
-
P
G
--
R
--
E
V-
P
-
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
-
D
-
I
---
D
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
R
T
E
E
---
Y
-
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
--
K
N
R
T
S
L
V
I
A
H
R
L
S
T
-
I
E
Q
A
D
E
I
V
V
V
E
D
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
63.50
27%
42
- C- -
3B5Z
2
MSBA_SALTY
A:
[10-554]
--------------------------------------------------------------------
W
Q
T
F
R
R
L
W
P
T
I
A
P
F
K
A
G
-
L
I
V
A
G
I
A
L
I
L
N
A
-
A
S
D
T
F
M
L
S
L
L
K
-
P
L
L
D
DG
F
G
-
K
T
DR-------
S
V
L
L
W
M
P
----
L
-----------------
V
V
I
G
L
M
I
-------
L
R
G
I
T
S
Y
I
S
S
----
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
A
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
V
V
L
A
P
I
V
S
I
A
I
R
V
-
V
S
-
K
R
F
-
R
S
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
K
M
R
L
-
Q
G
M
K
M
V
S
A
S
S
-------
I
S
D
P
I
I
Q
-------
L
I
A
S
L
A
L
A
F
-
V
-
L
Y
A
A
S
-----
F
P
SV
M
D
S
L
T
-
A
G
----
T
I
T
V
V
-------
F
--------
S
S
M
I
A
--
L
M
R
P
L
K
S
---
L
T
N
V
N
A
Q
F
--
Q
R
G
M
A
---
A
C
Q
T
----------
L
F
A
I
L
D
S
E
Q
--------
E
K
DEGKR
V
I
D
--
R
A
---
T
G
-
D
L
E
FR
N
V
T
F
T
Y
-
P
G
--
R
--
E
V-
P
-
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
-
D
-
I
---
D
E
G
H
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
R
T
E
E
---
Y
-
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
I
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
--
K
N
R
T
S
L
V
I
A
H
R
L
S
T
-
I
E
Q
A
D
E
I
V
V
V
E
D
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
62.69
26%
42
- C- -
3B5W
-
MSBA_ECOLI
A:
[10-556]
--------------------------------------------------------------------
W
Q
T
F
R
R
L
W
P
T
I
A
P
F
K
A
G
-
L
I
V
A
G
V
A
L
I
L
N
A
-
A
S
D
T
F
M
L
S
L
L
K
-
P
LLD
D
G
F
G
-
K
T
DR-------
S
V
L
V
W
M
P
----
L
-----------------
V
V
I
G
L
M
I
-------
L
R
G
I
T
S
Y
V
S
S
----
Y
C
I
S
W
V
S
G
K
V
V
M
T
M
R
R
R
L
F
G
H
M
M
G
M
P
V
S
F
F
D
K
Q
S
T
G
T
L
L
S
R
I
T
Y
D
S
E
Q
V
A
S
S
S
S
G
A
L
I
T
V
V
R
E
G
A
S
I
I
G
L
F
I
M
M
F
Y
Y
S
W
Q
L
S
I
I
L
I
V
L
A
P
I
V
S
I
A
I
R
V
-
V
S
-
K
R
F
-
R
N
I
S
K
N
M
Q
N
T
M
G
Q
V
T
T
S
A
E
Q
M
L
K
G
H
K
E
V
L
I
F
G
G
Q
E
V
E
T
K
R
F
D
K
V
S
N
R
M
R
L
-
Q
G
M
K
M
V
S
A
S
S
-------
I
S
D
P
I
I
Q
-------
L
I
A
S
L
A
L
A
F
-
V
-
L
Y
A
A
S
-----
F
P
SV
M
D
S
L
T
-
A
G
----
T
I
T
V
V
-------
F
--------
S
S
M
I
A
--
L
M
R
P
L
K
S
---
L
T
N
V
N
A
Q
F
--
Q
R
G
M
A
---
A
C
Q
T
----------
L
F
T
I
L
D
S
E
Q
E
K
D
E
G
K
R
V
I
E
-----
R
A
T
--
G
D
----
V
-
E
F
R
--
N
V
T
F
T
Y
-
P
G
--
R
--
D
V-
P
-
A
L
R
N
I
N
L
K
I
P
A
G
K
T
V
A
L
V
G
R
S
G
S
G
K
S
T
I
A
S
L
I
T
R
F
Y
-
D
-
I
---
D
E
G
E
I
L
M
D
G
H
D
L
R
E
Y
T
L
A
S
L
R
N
Q
V
A
L
V
S
Q
N
V
H
L
F
N
D
T
V
A
N
N
I
A
Y
A
R
-
T
E
---
Q
Y
S
R
E
Q
I
E
E
A
A
R
M
A
Y
A
M
D
F
I
N
K
M
D
N
G
L
D
T
V
I
G
E
N
G
V
L
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
L
R
D
S
P
I
L
I
L
D
E
A
T
S
A
L
D
T
E
S
E
R
A
I
Q
A
A
L
D
E
L
Q
--
K
N
R
T
S
L
V
I
A
H
R
L
S
T
-
I
E
K
A
D
E
I
V
V
V
E
D
G
V
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
57.32
37%
-60
- C3 -
4Q7L
-
Y288_THEMA
A:
[6-222]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
K
--
N
V
W
F
S
Y
-
D
K
--
K
--
K
--
P
-
V
L
K
D
I
T
F
H
I
K
P
G
Q
K
V
A
L
V
G
P
T
G
S
G
K
T
T
I
V
N
L
L
M
R
F
Y
-
D
-
V
---
D
R
G
Q
I
L
V
D
G
I
D
I
R
K
I
K
R
S
S
L
R
S
S
I
G
I
V
L
Q
D
T
I
L
F
S
T
T
V
K
E
N
L
K
Y
G
N
-
P
G
---
A
-
T
D
E
E
I
K
E
A
A
K
L
T
H
S
D
H
F
I
K
H
L
P
E
G
Y
E
T
V
L
T
D
N
G
E
D
L
S
Q
G
Q
R
Q
L
L
A
I
T
R
A
F
L
A
N
P
K
I
L
I
L
D
E
A
T
S
N
V
D
T
K
T
E
K
S
I
Q
A
A
M
W
K
L
M
--
E
G
K
T
S
I
I
I
A
H
R
L
N
T
-
I
K
N
A
D
L
I
I
V
L
R
D
G
E
I
V
E
M
G
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
56.55
35%
-72
- C3 -
2FGJ
2
D:
[13-226]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
F
R
Y
-
K
P
--
D
--
S
--
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
-
I
-
P
E--
N
-
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
N
-
P
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
G
R
T
V
I
I
I
A
A
R
L
S
T
-
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
56.48
35%
-70
- C3 -
1XEF
3
HLYBP_ECOLX
B:
[7-220]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
F
R
Y
-
K
P
--
D
--
S
--
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
-
I
-
P
E--
N
-
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
N
-
P
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
G
R
T
V
I
I
I
A
A
R
L
S
T
-
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
56.34
35%
-65
- C3 -
2FGK
2
HLYBP_ECOLX
B:
[13-226]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
F
R
Y
-
K
P
--
D
--
S
--
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
-
I
-
P
E--
N
-
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
N
-
P
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
G
R
T
V
I
I
I
A
H
R
L
S
T
-
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
56.18
35%
-67
- C3 -
2FGK
2
D:
[13-226]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
F
R
Y
-
K
P
--
D
--
S
--
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
-
I
-
P
E--
N
-
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
N
-
P
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
G
R
T
V
I
I
I
A
H
R
L
S
T
-
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
55.84
35%
-71
- C3 -
2FGJ
2
HLYBP_ECOLX
A:
[13-226]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
F
R
Y
-
K
P
--
D
--
S
--
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
-
I
-
P
E--
N
-
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
N
-
P
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
G
R
T
V
I
I
I
A
A
R
L
S
T
-
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
55.61
35%
-71
- C3 -
1XEF
3
D:
[7-220]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
F
R
Y
-
K
P
--
D
--
S
--
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
-
I
-
P
E--
N
-
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
N
-
P
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
G
R
T
V
I
I
I
A
A
R
L
S
T
-
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
55.54
35%
-64
- C3 -
2FGK
2
HLYBP_ECOLX
A:
[13-226]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
F
R
Y
-
K
P
--
D
--
S
--
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
-
I
-
P
E--
N
-
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
N
-
P
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
G
R
T
V
I
I
I
A
H
R
L
S
T
-
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
55.49
35%
-72
- C3 -
1XEF
3
HLYBP_ECOLX
C:
[7-220]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
F
R
Y
-
K
P
--
D
--
S
--
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
-
I
-
P
E--
N
-
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
N
-
P
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
G
R
T
V
I
I
I
A
A
R
L
S
T
-
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
PsiBlast_CBE
55.44
35%
-66
- C3 -
2FFB
1
A:
[13-226]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
F
R
Y
-
K
P
--
D
--
S
--
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
-
I
-
P
E--
N
-
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
N
-
P
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
G
R
T
V
I
I
I
A
H
R
L
S
T
-
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
54.99
35%
-70
- C3 -
1XEF
3
HLYBP_ECOLX
A:
[7-220]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
F
R
Y
-
K
P
--
D
--
S
--
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
-
I
-
P
E--
N
-
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
N
-
P
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
G
R
T
V
I
I
I
A
A
R
L
S
T
-
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
54.84
35%
-69
- C3 -
2PMK
1
A:
[8-222]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
R
F
R
Y
-
K
P
--
D
--
S
--
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
-
I
-
P
E--
N
-
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
N
-
P
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
G
R
T
V
I
I
I
A
H
R
L
S
T
-
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
54.57
34%
-69
- C3 -
3B5J
1
A:
[8-222]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
R
F
R
Y
-
K
P
--
D
--
S
--
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
A
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
-
I
-
P
E--
N
-
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
N
-
P
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
G
R
T
V
I
I
I
A
H
R
L
S
T
-
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
53.99
35%
-66
- C3 -
2FGK
2
HLYBP_ECOLX
C:
[13-226]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
F
R
Y
-
K
P
--
D
--
S
--
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
-
I
-
P
E--
N
-
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
N
-
P
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
G
R
T
V
I
I
I
A
H
R
L
S
T
-
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
53.82
35%
-66
- C3 -
2FF7
1
A:
[13-226]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
F
R
Y
-
K
P
--
D
--
S
--
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
-
I
-
P
E--
N
-
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
N
-
P
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
G
R
T
V
I
I
I
A
H
R
L
S
T
-
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
53.41
35%
-68
- C3 -
2FFA
2
A:
[13-226]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
F
R
Y
-
K
P
--
D
--
S
--
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
-
I
-
P
E--
N
-
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
N
-
P
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
G
R
T
V
I
I
I
A
A
R
L
S
T
-
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
53.40
35%
-70
- C3 -
2FGJ
2
HLYBP_ECOLX
B:
[13-226]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
F
R
Y
-
K
P
--
D
--
S
--
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
-
I
-
P
E--
N
-
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
N
-
P
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
G
R
T
V
I
I
I
A
A
R
L
S
T
-
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
52.92
35%
-71
- C3 -
2FGJ
2
HLYBP_ECOLX
C:
[13-226]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
F
R
Y
-
K
P
--
D
--
S
--
P
V
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
-
I
-
P
E--
N
-
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
N
-
P
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
G
R
T
V
I
I
I
A
A
R
L
S
T
-
V
K
N
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
PsiBlast_CBE
51.47
32%
-61
- C3 -
5DGX
1
?
A:
[29-236]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
--
E
--
H
--
K
-
V
L
S
G
V
S
V
D
I
K
A
G
Q
T
V
A
F
V
G
K
S
G
S
G
K
T
T
L
T
S
I
I
S
R
F
Y
T
Q
-
H
---
E
-
G
E
I
L
L
D
G
V
D
T
R
E
L
T
L
E
N
L
R
S
H
L
S
I
V
S
Q
N
V
H
L
F
D
D
T
V
Y
N
N
I
A
F
G
---
E
---
V
-
S
E
E
E
V
I
D
A
L
K
R
A
N
A
Y
E
F
V
Q
E
L
S
D
G
I
N
T
N
I
G
N
N
G
S
K
L
S
G
G
Q
R
Q
R
I
S
I
A
R
A
L
L
K
N
A
P
V
L
I
F
D
E
----------------
L
E
S
L
T
--
K
S
C
T
T
I
V
I
A
H
R
L
S
T
-
V
E
N
A
D
K
I
V
V
M
D
G
G
R
V
V
E
S
G
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
HHSearch
51.43
34%
-61
- C3 -
2FF7
1
A:
[5-225]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
---
D
I
-
T
F
R
--
N
I
R
F
R
Y
-
K
P
D-
S
--
P
--
V
-
I
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
-
I
-
P
---
E
N
G
Q
V
L
I
D
G
H
D
L
A
L
A
D
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
S
I
I
D
N
I
S
L
A
N
-
P
G
---
M
-
S
V
E
K
V
I
Y
A
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
N
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
Y
E
S
E
H
V
I
M
R
N
M
H
K
I
C
--
K
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
50.95
34%
-60
- C3 -
4S0F
2
?
A:
[490-701]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
R
--
N
V
D
F
R
Y
-
G
L
--
R
--
K
--
P
-
V
L
K
N
I
N
L
T
I
P
K
G
K
T
V
A
I
V
G
E
S
G
S
G
K
T
T
L
A
K
L
L
M
N
F
Y
-
S
-
P
---
E
K
G
D
I
L
I
N
G
H
S
I
K
N
I
S
L
E
L
I
R
K
K
I
A
F
V
S
Q
D
V
F
I
F
S
G
T
V
K
E
N
L
C
L
G
N
-
E
N
---
V
-
D
M
D
E
I
I
K
A
A
K
M
A
N
A
H
D
F
I
E
K
L
P
L
K
Y
D
T
F
L
N
E
S
G
A
N
L
S
E
G
Q
K
Q
R
L
A
I
A
R
A
L
L
K
K
P
D
I
L
I
L
D
Q
A
T
S
N
L
D
S
I
T
E
N
H
I
K
D
A
I
Y
G
L
E
--
D
D
V
T
V
I
I
I
A
H
R
L
S
T
-
I
V
N
C
D
K
I
Y
L
L
K
D
G
E
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
50.16
36%
-57
- C3 -
4PL0
3
MCJD_ECOLX
B:
[349-546]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
S
F
S
Y
-
S
D
--
D
--
K
--
K
-
I
L
N
S
V
S
L
D
L
F
T
G
K
M
Y
S
L
T
G
P
S
G
S
G
K
S
T
L
V
K
I
I
S
G
Y
Y
K
N
-
Y
---
F
-
G
D
I
Y
L
N
D
I
S
L
R
N
I
S
D
E
D
L
N
D
A
I
Y
Y
L
T
Q
D
D
Y
I
F
M
D
T
L
R
F
N
L
R
L
A
N
-
Y
D
---
A
-
S
E
N
E
I
F
K
V
L
K
L
A
N
L
S
V
-
V
N
N
E
P
V
S
L
D
T
H
L
I
N
R
G
N
N
Y
S
G
G
Q
K
Q
R
I
S
L
A
R
L
F
L
R
K
P
A
I
I
I
I
D
E
A
T
S
A
L
D
Y
I
N
E
S
E
I
L
S
S
I
R
T
H
F
--
P
D
A
L
I
I
N
I
S
H
R
I
N
L
-
L
E
C
S
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
49.80
34%
-59
- C3 -
4S0F
2
?
B:
[490-701]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
R
--
N
V
D
F
R
Y
-
G
L
--
R
--
K
--
P
-
V
L
K
N
I
N
L
T
I
P
K
G
K
T
V
A
I
V
G
E
S
G
S
G
K
T
T
L
A
K
L
L
M
N
F
Y
-
S
-
P
---
E
K
G
D
I
L
I
N
G
H
S
I
K
N
I
S
L
E
L
I
R
K
K
I
A
F
V
S
Q
D
V
F
I
F
S
G
T
V
K
E
N
L
C
L
G
N
-
E
N
---
V
-
D
M
D
E
I
I
K
A
A
K
M
A
N
A
H
D
F
I
E
K
L
P
L
K
Y
D
T
F
L
N
E
S
G
A
N
L
S
E
G
Q
K
Q
R
L
A
I
A
R
A
L
L
K
K
P
D
I
L
I
L
D
Q
A
T
S
N
L
D
S
I
T
E
N
H
I
K
D
A
I
Y
G
L
E
--
D
D
V
T
V
I
I
I
A
H
R
L
S
T
-
I
V
N
C
D
K
I
Y
L
L
K
D
G
E
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
49.45
36%
-59
- C3 -
4PL0
3
MCJD_ECOLX
A:
[349-546]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
S
F
S
Y
-
S
D
--
D
--
K
--
K
-
I
L
N
S
V
S
L
D
L
F
T
G
K
M
Y
S
L
T
G
P
S
G
S
G
K
S
T
L
V
K
I
I
S
G
Y
Y
K
N
-
Y
---
F
-
G
D
I
Y
L
N
D
I
S
L
R
N
I
S
D
E
D
L
N
D
A
I
Y
Y
L
T
Q
D
D
Y
I
F
M
D
T
L
R
F
N
L
R
L
A
N
-
Y
D
---
A
-
S
E
N
E
I
F
K
V
L
K
L
A
N
L
S
V
-
V
N
N
E
P
V
S
L
D
T
H
L
I
N
R
G
N
N
Y
S
G
G
Q
K
Q
R
I
S
L
A
R
L
F
L
R
K
P
A
I
I
I
I
D
E
A
T
S
A
L
D
Y
I
N
E
S
E
I
L
S
S
I
R
T
H
F
--
P
D
A
L
I
I
N
I
S
H
R
I
N
L
-
L
E
C
S
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------