@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1293: (2016-03-23 )
MVQLFSAFDRETIERNLQEEKFDLVIVGGGITGAGIALDATSRGMSVALVEMGDFASGTSSRSTKLVHGGLRYLQQFEIKEVADLGKERAIVYENGPHVTTPEWMMLPFHKGGNMGKTTASFGIRLYDYLAGVKKNERRKILSAKETLAKNPFVKKDGLKGSGYYVEYRTDDARLTIEVMKKAVELGANAINYTKAEHFLYDDNKQVVGVTVTDRLSGKAYDIKGHRVINAAGPWVDKVRKLDYATNNKHLRLTKGIHLVIDKQKFPMEQAVYFDTPDGRMVFAIPRDKKVYVGTTDTVYDEAVINPKALESDHNYVIKAINYMFPDVHITEKDIESSWAGVRPLIYEEGKDPSEISRKDEVWFSESGLITMAGGKLTGYRKMAEKLLDDVSKTLAKETGKKYKTVQTKHLPISGGDIGGSEQLEAFLSKKAKEGNNRFGWTLEEGREMAKRFGSNIDQLFTYAQEHKEQNETTLPNSLYAELRYSIQHEAVTTPIDFLLRRTGYLLFDMPYLLEWKDAVVDEMAKQFHWSDDVKQTYIEELNIQINDAREPADWHDR
Atome Classification :
(20 SA)
.........10........20........30........40....-.-...50..-..--..--..60....--....70...----.-....80........90......-----..-100.......110.----.---.....120....----....130....--------...140.......--.150....----.---..160...-..-..170-.........180.......190...---....200.......210--.......220.......230.......240..-..--.-..250-----........260....-.---------..270.-.--.--.--.--.--.280-.---...-.-.-.290.....--...300------------------.---.--------...--...310-.........320-.......330.......340......-----------..------.350......------.360........370..--.---.---...380.......390.......400.......410.......420.......430--.......440...-....450.......460......--.470-.......480.......490.......500.......510.......520.......530...--....540.......550......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
V
Q
L
F
S
A
F
D
R
E
T
I
E
R
N
L
QEEKF
D
L
V
I
VGGGITGA
G
I
A
L
DATSRG
M
-
S
-
V
A
L
V
EMG-DF--AS--GTSSRS
T
K
--
L
V
H
G
G
L
R
Y
L
----
Q
-
Q
F
E
I
K
E
V
A
D
LGK
E
R
A
I
V
Y
ENGP-----HV-TTPE
W
M
M
L
P
F
HKGG----N---MGK
T
T
A
S
-
F
G
I
R
----
L
Y
D
Y
L
AGVK
K
N
--------
E
R
R
K
-
I
L
S
A
K
E
T
L--AKNPFVKK----D---GLKGS
G
Y
Y
-
V
E
-
Y
RT---DD
A
R
L
T
I
E
V
M
K
K
A
V
E
LGANAINYTK---A
E
H
F
L
YDDN
K
Q
V
V
G
V
T
V
--TDRLSG
K
A
Y
DIKG
H
R
V
INAAG
P
W
V
D
K
V
R
K
LDY-AT--N-NK
H
L
------
R
L
TK
G
I
H
L
V
I
DKQKF-P---------ME
Q
A
V
Y
-
F
--D--T--P--D--G
R
M
V
-
F
---
A
IP-R-D-
K
K
-
V
Y
VGTT--DTVY-D------------------E---A--------VIN--
P
K
AL---ESDH
N
Y
V
I
K
A
I
N
-
Y
MFPD
V
H
I
T
E
K
D
I
E
S
SWA--GVR
P
L
I
-----------YE------EGK
D
P
S
E
ISR------KD-
E
V
W
FSES
G
L
I
T
MAG--G---K---LT
G
Y
R
K
M
A
E
K
L
L
D
D
V
S
K
T
L
A
K
ETGKK
Y
K
T
V
Q
T
K
HLPISGGDIG
G
S
E
Q
L
E
A
F
L
S
K
K
A
--KEGNNRFGW
T
L
E
E
-
G
R
E
M
A
K
R
FGS
N
I
D
Q
L
F
T
Y
A
Q
E
H
K--EQNE-TTL
P
N
S
L
Y
A
E
L
R
Y
S
I
QHEAVT
T
P
I
D
F
L
L
R
RT
G
Y
L
L
FD
M
P
Y
L
L
E
W
K
D
A
V
V
D
E
M
A
K
QFHW
S
D
D
V
K
--
Q
T
Y
I
E
EL
N
I
Q
INDAREPADWHDR
1
PsiBlast_PDB
96.02
52%
-68
- C2 -
3DA1
1
?
A:
[2-544]
----
F
S
A
K
K
R
D
K
C
I
G
E
M
S
E
K
Q
L
D
L
L
V
I
G
G
G
I
T
G
A
G
I
A
L
D
A
Q
V
R
G
I
-
Q
-
T
G
L
V
E
M
N
-
D
F
--
A
S
--
G
T
S
S
R
S
T
K
--
L
V
H
G
--------------------
V
G
K
E
R
A
I
V
Y
E
N
A
P
-----
H
V
-
T
T
P
E
W
M
L
L
P
I
F
K
-----------------------------------------------
R
Y
-
M
L
N
E
K
Q
T
L
--
E
K
E
P
L
L
R
K
----
E
---
N
L
K
G
G
G
I
Y
-
V
E
-
Y
R
T
---
D
D
A
R
L
T
L
E
I
M
K
E
A
V
A
R
G
A
V
A
L
N
Y
M
K
---
V
E
S
F
I
Y
D
Q
G
K
-
V
V
G
V
V
A
--
K
D
R
L
T
D
T
T
H
T
I
Y
A
K
K
V
V
N
A
A
G
P
W
V
D
T
L
R
E
K
D
R
-
S
K
--
H
-
G
K
Y
L
------
K
L
S
K
G
V
H
L
V
V
D
Q
S
R
F
-
P
---------
L
R
Q
A
V
Y
-
F
--
D
--
T
E-
S
--
D
--
G
R
M
I
-
F
---
A
I
P
-
R
-
E
-
G
K
-
T
Y
I
G
T
T
--
D
T
F
Y
-
D
------------------
K
---
D
--------
I
A
S
--
P
R
M
T
---
V
E
D
R
D
Y
I
L
A
A
A
N
-
Y
M
F
P
S
L
R
L
T
A
D
D
V
E
S
S
W
A
--
G
L
R
P
L
I
-----------
H
E
-----------------------
D
-
E
I
F
F
S
D
S
G
L
I
S
I
A
G
--
G
---
K
---
L
T
G
Y
R
K
M
A
E
R
T
V
D
A
V
A
Q
G
L
N
V
N
-----
E
P
C
T
T
A
A
I
R
L
S
G
G
L
A
E
G
A
Q
G
F
P
R
F
L
D
E
A
S
--
R
K
G
-
A
K
L
G
F
D
A
D
E
-
V
R
R
L
A
K
L
Y
G
S
N
V
D
H
V
L
N
Y
A
Y
E
G
K
--
E
E
A
E
H
Y
G
L
P
A
L
L
L
G
Q
L
Q
Y
G
V
E
Q
E
M
V
A
T
P
L
D
F
F
V
R
R
T
G
A
L
F
F
N
I
S
L
V
H
Q
W
K
E
A
V
L
R
W
M
A
E
E
F
S
W
T
E
E
E
K
--
T
R
F
Q
N
E
L
E
T
E
L
K
M
A
V
D
P
------
103
HHSearch
95.36
53%
-69
- C2 -
3DA1
1
?
A:
[5-545]
-------
K
K
R
D
K
C
I
G
E
M
S
E
K
Q
L
D
L
L
V
I
G
G
G
I
T
G
A
G
I
A
L
D
A
Q
V
R
G
I
-
Q
-
T
G
L
V
E
M
N
-
D
F
--
A
S
--
G
T
S
S
R
S
T
K
--
L
V
H
G
--------------------
V
G
K
E
R
A
I
V
Y
E
N
A
P
-----
H
V
-
T
T
P
E
W
M
L
L
P
I
F
K
-----------------------------------------------
R
Y
-
M
L
N
E
K
Q
T
L
--
E
K
E
P
L
L
R
K
----
E
---
N
L
K
G
G
G
I
Y
-
V
E
-
Y
R
T
---
D
D
A
R
L
T
L
E
I
M
K
E
A
V
A
R
G
A
V
A
L
N
Y
M
K
---
V
E
S
F
I
Y
D
-
Q
G
K
V
V
G
V
V
A
--
K
D
R
L
T
D
T
T
H
T
I
Y
A
K
K
V
V
N
A
A
G
P
W
V
D
T
L
R
E
K
D
R
-
S
K
--
H
-
G
K
Y
L
------
K
L
S
K
G
V
H
L
V
V
D
Q
S
R
F
-
P
---------
L
R
Q
A
V
Y
-
F
--
D
--
T
E-
S
--
D
--
G
R
M
I
-
F
---
A
I
P
-
R
-
E
-
G
K
-
T
Y
I
G
T
T
--
D
T
F
Y
-
D
------------------
K
---
D
--------
I
A
S
--
P
R
M
T
---
V
E
D
R
D
Y
I
L
A
A
A
N
-
Y
M
F
P
S
L
R
L
T
A
D
D
V
E
S
S
W
A
--
G
L
R
P
L
I
-----------
H
E
-----------------------
D
-
E
I
F
F
S
D
S
G
L
I
S
I
A
G
--
G
---
K
---
L
T
G
Y
R
K
M
A
E
R
T
V
D
A
V
A
Q
G
L
----
N
V
N
-
E
P
C
T
T
A
A
I
R
L
S
G
G
L
A
E
G
A
Q
G
F
P
R
F
L
D
E
A
S
R
K
G
A
---
K
L
G
F
D
A
D
E
-
V
R
R
L
A
K
L
Y
G
S
N
V
D
H
V
L
N
Y
A
Y
E
G
K
E
E
A
E
H
--
Y
G
L
P
A
L
L
L
G
Q
L
Q
Y
G
V
E
Q
E
M
V
A
T
P
L
D
F
F
V
R
R
T
G
A
L
F
F
N
I
S
L
V
H
Q
W
K
E
A
V
L
R
W
M
A
E
E
F
S
W
T
E
E
E
K
--
T
R
F
Q
N
E
L
E
T
E
L
K
M
A
V
D
P
L
-----
104
HHSearch
94.38
42%
-57
- C2 -
2RGH
2
?
A:
[14-566]
--
C
M
F
S
N
K
T
R
Q
D
S
I
Q
K
M
Q
Q
E
E
L
D
L
L
I
I
G
G
G
I
T
G
A
G
V
A
V
Q
A
A
A
S
G
I
-
K
-
T
G
L
I
E
M
Q
-
D
F
--
A
E
--
G
T
S
S
R
S
T
K
--
L
V
H
G
G
I
R
Y
L
----
K
-
T
F
D
V
E
V
V
A
D
T
V
G
E
R
A
V
V
Q
G
I
A
P
-----
H
I
-
P
K
P
D
P
M
L
L
P
I
Y
E
D
E
----
G
ATT
F
N
M
F
S
V
K
-
V
A
M
D
----
L
Y
D
K
L
A
N
V
T
G
T
K-------
Y
E
N
Y
-
T
L
T
P
E
E
V
L
--
E
R
E
P
F
L
K
K
----
E
---
G
L
K
G
A
G
V
Y
-
L
D
-
F
R
N
---
N
D
A
R
L
V
I
D
N
I
K
K
A
A
E
D
G
A
Y
L
V
S
K
M
K
---
A
V
G
F
L
Y
E
-
G
D
Q
I
V
G
V
K
A
--
R
D
L
L
T
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V
I
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I
K
A
K
L
V
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N
T
S
G
P
W
V
D
K
V
R
N
L
N
F
T
R
P
--
V
-
S
P
K
M
------
R
P
T
K
G
I
H
L
V
V
D
A
K
K
L
-
P
---------
V
P
Q
P
T
Y
-
F
--
D
--
T
GK
Q
--
D
--
G
R
M
V
-
F
---
A
I
P
-
R
-
E
-
N
K
-
T
Y
F
G
T
T
--
D
T
D
Y
-
Q
------------------
G
---
D
--------
F
T
D
--
P
K
V
T
---
Q
E
D
V
D
Y
L
L
D
V
I
N
-
H
R
Y
P
E
A
N
I
T
L
A
D
I
E
A
S
W
A
--
G
L
R
P
L
L
-----------
I
G
-----------------------
S
-
S
L
E
R
E
P
D
G
L
L
T
L
S
G
--
G
---
K
---
I
T
D
Y
R
K
M
A
E
G
A
L
R
L
I
R
Q
L
L
K
E
E
Y
G
I
E
T
K
E
I
D
S
K
K
Y
Q
I
S
G
G
N
F
D
P
T
K
-
L
E
E
T
V
T
E
L
A
--
K
E
-
G
V
A
A
G
L
E
E
E
D
-
A
T
Y
I
A
D
F
Y
G
T
N
A
R
R
I
F
E
L
A
K
E
M
----
A
P
Y
-
P
G
L
S
L
A
E
S
A
R
L
R
Y
G
L
E
E
E
M
V
L
A
P
G
D
Y
L
I
R
R
T
N
H
L
L
F
E
R
D
Q
L
D
E
I
K
Q
P
V
I
D
A
I
A
E
Y
F
G
W
T
E
E
E
K
--
A
Q
Q
T
K
R
L
E
A
L
I
A
E
S
D
L
R
E
-----
2
PsiBlast_PDB
91.41
42%
-52
- C2 -
2RGH
2
?
A:
[16-566]
----
F
S
N
K
T
R
Q
D
S
I
Q
K
M
Q
Q
E
E
L
D
L
L
I
I
G
G
G
I
T
G
A
G
V
A
V
Q
A
A
A
S
G
I
-
K
-
T
G
L
I
E
M
Q
-
D
F
--
A
E
--
G
T
S
S
R
S
T
K
--
L
V
H
G
G
I
R
Y
L
----
K
-
T
F
D
V
E
V
V
A
D
T
V
G
E
R
A
V
V
Q
G
I
A
P
-----
H
I
-
P
K
P
D
P
M
L
L
P
I
Y
E
------
D
---
E
G
A
T
T
F
N
M
F
S
V
K
V
A
M
D
L
Y
D
K
L
A
N
V
T
G
T
--------
K
Y
E
N
Y
T
L
T
P
E
E
V
L
--
E
R
E
P
F
L
K
K
----
E
---
G
L
K
G
A
G
V
Y
-
L
D
-
F
R
N
---
N
D
A
R
L
V
I
D
N
I
K
K
A
A
E
D
G
A
Y
L
V
S
K
M
K
---
A
V
G
F
L
Y
E
G
D
-
Q
I
V
G
V
K
A
--
R
D
L
L
T
D
E
V
I
E
I
K
A
K
L
V
I
N
T
S
G
P
W
V
D
K
V
R
N
L
N
F
-
T
R
--
P
V
S
P
K
M
------
R
P
T
K
G
I
H
L
V
V
D
A
K
K
L
-
P
---------
V
P
Q
P
T
Y
-
F
--
D
--
T
GK
Q
--
D
--
G
R
M
V
-
F
---
A
I
P
-
R
-
E
-
N
K
-
T
Y
F
G
T
T
--
D
T
D
Y
-
Q
------------------
G
---
D
--------
F
T
D
--
P
K
V
T
---
Q
E
D
V
D
Y
L
L
D
V
I
N
-
H
R
Y
P
E
A
N
I
T
L
A
D
I
E
A
S
W
A
--
G
L
R
P
L
L
-----------
I
G
-----------------------
S
-
S
L
E
R
E
P
D
G
L
L
T
L
S
G
--
G
---
K
---
I
T
D
Y
R
K
M
A
E
G
A
L
R
L
I
R
Q
L
L
K
E
E
Y
G
I
E
T
K
E
I
D
S
K
K
Y
Q
I
S
G
G
N
F
D
P
T
-
K
L
E
E
T
V
T
E
L
A
--
K
E
G
V
A
A
-
G
L
E
E
E
D
-
A
T
Y
I
A
D
F
Y
G
T
N
A
R
R
I
F
E
L
A
K
E
M
A
--
P
Y
P
G
-
L
S
L
A
E
S
--
A
R
L
R
Y
G
L
E
E
E
M
V
L
A
P
G
D
Y
L
I
R
R
T
N
H
L
L
F
E
R
D
Q
L
D
E
I
K
Q
P
V
I
D
A
I
A
E
Y
F
G
W
T
E
E
E
K
A
Q
Q
T
K
R
L
E
A
L
I
A
E
S
D
L
R
E
-------
3
PsiBlast_PDB
91.38
40%
-58
- C2 -
2RGO
1
?
A:
[1-602]
---
M
F
S
N
K
T
R
Q
D
S
I
Q
K
M
Q
Q
E
E
L
D
L
L
I
I
G
G
G
I
T
G
A
G
V
A
V
Q
A
A
A
S
G
I
-
K
-
T
G
L
I
E
M
Q
-
D
F
--
A
E
--
G
T
S
S
R
S
T
K
--
L
V
H
G
G
I
R
Y
L
----
K
-
T
F
D
V
E
V
V
A
D
T
V
G
E
R
A
V
V
Q
G
I
A
P
-----
H
I
-
P
K
P
D
P
M
L
L
P
I
Y
E
------
D
---
E
G
A
T
T
F
N
M
F
S
V
K
V
A
M
D
L
Y
D
K
L
A
N
V
T
G
T
--------
K
Y
E
N
Y
T
L
T
P
E
E
V
L
--
E
R
E
P
F
L
K
K
----
E
---
G
L
K
G
A
G
V
Y
-
L
D
-
F
R
N
---
N
D
A
R
L
V
I
D
N
I
K
K
A
A
E
D
G
A
Y
L
V
S
K
M
K
---
A
V
G
F
L
Y
E
G
D
-
Q
I
V
G
V
K
A
--
R
D
L
L
T
D
E
V
I
E
I
K
A
K
L
V
I
N
T
S
G
P
W
V
D
K
V
R
N
L
N
F
-
T
R
--
P
V
S
P
K
M
------
R
P
T
K
G
I
H
L
V
V
D
A
K
K
L
-
P
---------
V
P
Q
P
T
Y
-
F
--
D
--
T
GK
Q
--
D
--
G
R
M
V
-
F
---
A
I
P
-
R
-
E
-
N
K
-
T
Y
F
G
T
T
--
D
T
D
Y
-
Q
------------------
G
---
D
--------
F
T
D
--
P
K
V
T
---
Q
E
D
V
D
Y
L
L
D
V
I
N
-
H
R
Y
P
E
A
N
I
T
L
A
D
I
E
A
S
W
A
--
G
L
R
P
L
L
IGNSGSDYNGG--------------
T
I
S
R
------
G
S
-
S
L
E
R
E
P
D
G
L
L
T
L
S
G
--
G
---
K
---
I
T
D
Y
R
K
M
A
E
G
A
L
R
L
I
R
Q
L
L
K
E
E
Y
G
I
E
T
K
E
I
D
S
K
K
Y
Q
I
S
G
G
N
F
D
P
T
-
K
L
E
E
T
V
T
E
L
A
--
K
E
G
V
A
A
-
G
L
E
E
E
D
-
A
T
Y
I
A
D
F
Y
G
T
N
A
R
R
I
F
E
L
A
K
E
-
A
--
P
Y
P
G
-
L
S
L
A
E
S
--
A
R
L
R
Y
G
L
E
E
E
M
V
L
A
P
G
D
Y
L
I
R
R
T
N
H
L
L
F
E
R
D
Q
L
D
E
I
K
Q
P
V
I
D
A
I
A
E
Y
F
G
W
T
E
E
E
K
A
Q
Q
T
K
R
L
E
A
L
I
A
E
S
D
L
R
E
-------
21
PsiBlast_CBE
84.01
40%
-61
- C2 -
2RGO
1
?
B:
[1-602]
---
M
F
S
N
K
T
R
Q
D
S
I
Q
K
M
Q
--
E
L
D
L
L
I
I
G
G
G
I
T
G
A
G
V
A
V
Q
A
A
A
S
G
I
-
K
-
T
G
L
I
E
M
Q
-
D
F
--
A
E
--
G
T
S
S
R
S
T
K
--
L
V
H
G
G
I
R
Y
L
----
K
-
T
F
D
V
E
V
V
A
D
T
V
G
E
R
A
V
V
Q
G
I
A
P
-----
H
I
-
P
K
P
D
P
M
L
L
P
I
Y
E
------
D
---
E
--
T
T
F
N
M
F
S
V
K
V
A
M
D
L
Y
D
K
L
A
N
V
T
G
T
--------
K
Y
E
N
Y
T
L
T
P
E
E
V
L
--
E
R
E
P
F
L
K
K
----
E
---
G
L
K
G
A
G
V
Y
-
L
D
-
F
R
N
---
N
D
A
R
L
V
I
D
N
I
K
K
A
A
E
D
G
A
Y
L
V
S
K
M
K
---
A
V
G
F
L
Y
-
G
D
-
Q
I
V
G
V
K
A
--
R
D
L
L
T
D
E
V
I
E
I
K
A
K
L
V
I
N
T
S
G
P
W
V
D
K
V
R
N
L
N
F
-----
P
V
S
P
K
M
------
R
P
T
K
G
I
H
L
V
V
D
A
K
K
L
-
P
---------
V
P
Q
P
T
Y
-
F
--
D
--
T
GK
Q
--
D
--
G
R
M
V
-
F
---
A
I
P
-
R
-
E
-
N
K
-
T
Y
F
G
T
T
--
D
T
D
Y
-
Q
------------------
G
---
D
--------
F
T
D
--
P
K
V
T
---
Q
E
D
V
D
Y
L
L
D
V
I
N
-
H
R
Y
P
E
A
N
I
T
L
A
D
I
E
A
S
W
A
--
G
L
R
P
L
L
IGNSGSDYNGG---------------
I
S
R
------
G
S
-
S
L
E
R
E
P
D
G
L
L
T
L
S
G
--
G
---
K
---
I
T
D
Y
R
K
M
A
E
G
A
L
R
L
I
R
Q
L
L
K
E
E
Y
G
I
E
T
K
E
I
D
S
K
K
Y
Q
I
S
G
G
N
F
D
P
T
-
K
----------------------
E
D
-
A
T
Y
I
A
D
F
Y
G
T
N
A
R
R
I
F
E
L
A
---
A
--
P
Y
P
G
-
L
S
L
A
E
S
--
A
R
L
R
Y
G
L
E
E
E
M
V
L
A
P
G
D
Y
L
I
R
R
T
N
H
L
L
F
E
R
D
Q
L
D
E
I
K
Q
P
V
I
D
A
I
A
E
Y
F
G
W
T
E
E
E
K
A
Q
Q
T
K
R
L
E
A
L
I
A
E
S
D
L
R
E
-------
5
PsiBlast_PDB
62.01
30%
-34
- C2 -
2R45
27
GLPD_ECOLI
A:
[27-471]
--------------------------------------------
L
-
S
-
V
L
M
L
E
A
Q
-
D
L
--
A
C
--
A
T
S
S
A
S
S
K
--
L
I
H
G
G
L
R
Y
L
----
E
-
H
Y
E
F
R
L
V
S
E
A
L
A
E
R
E
V
L
L
K
M
A
P
-----
H
I
-
A
F
P
M
R
F
R
L
P
-
H
R
P
H
----
L
---
R
P
A
W
M
I
R
-
I
G
L
F
----
M
Y
D
H
L
G
--------------
K
R
T
-
S
L
P
G
S
T
G
L
R
F
G
A
N
S
V
L
K
P
----
E
----
I
K
R
G
F
E
Y
-
S
D
-
C
W
V
---
D
D
A
R
L
V
L
A
N
A
Q
M
V
V
R
K
G
G
E
V
L
T
R
T
R
---
A
T
S
A
R
R
E
N
G
L
W
I
V
E
A
E
D
--
I
D
--
T
G
K
K
Y
S
W
Q
A
R
G
L
V
N
A
T
G
P
W
V
K
Q
-----
F
-
F
D
--
D
-
G
M
H
L
PSP
Y
G
I
R
L
I
K
G
S
H
I
V
V
P
R
V
H
--
T
---------
Q
K
Q
A
Y
I
-
L
--
Q
--
N
--
E
--
D
--
K
R
I
V
-
F
---
V
I
P
W
M
-
D
-
E
F
-
S
I
I
G
T
T
--
D
V
E
Y
-
K
------------------
G
--------------
D
--
P
K
A
V
K
I
E
E
S
E
I
N
Y
L
L
N
V
Y
N
-
T
H
F
K
K
-
Q
L
S
R
D
D
I
V
W
T
Y
S
--
G
V
R
P
L
C
-----------
D
D
------
E
S
D
S
P
Q
A
I
T
R
D
Y
T
L
D
I
H
D
-
E
N
--
G
K
A
P
L
L
S
V
F
G
--
G
---
K
---
L
T
T
Y
R
K
L
A
E
H
A
L
E
K
L
T
P
Y
Y
-
Q
G
I
G
P
A
W
----
T
K
E
S
V
L
P
G
G
A
I
E
G
D
R
------
D
D
Y
A
--
A
R
L
R
R
R
Y
P
F
L
T
E
S
L
A
R
H
Y
A
R
T
Y
G
S
N
S
E
L
L
L
G
N
A
G
T
V
S
--
D
L
G
E
-
D
F
G
H
E
F
Y
E
A
E
L
K
Y
L
V
D
H
E
W
V
R
R
A
D
D
A
L
W
R
R
T
---------------------------------------------------------
8
PsiBlast_PDB
61.27
30%
-31
- C2 -
2R4J
22
GLPD_ECOLI
A:
[27-471]
--------------------------------------------
L
-
S
-
V
L
M
L
E
A
Q
-
D
L
--
A
C
--
A
T
S
S
A
S
S
K
--
L
I
H
G
G
L
R
Y
L
----
E
-
H
Y
E
F
R
L
V
S
E
A
L
A
E
R
E
V
L
L
K
M
A
P
-----
H
I
-
A
F
P
M
R
F
R
L
P
-
H
R
P
H
----
L
---
R
P
A
W
M
I
R
-
I
G
L
F
----
M
Y
D
H
L
G
--------------
K
R
T
-
S
L
P
G
S
T
G
L
R
F
G
A
N
S
V
L
K
P
----
E
----
I
K
R
G
F
E
Y
-
S
D
-
C
W
V
---
D
D
A
R
L
V
L
A
N
A
Q
M
V
V
R
K
G
G
E
V
L
T
R
T
R
---
A
T
S
A
R
R
E
N
G
L
W
I
V
E
A
E
D
--
I
D
--
T
G
K
K
Y
S
W
Q
A
R
G
L
V
N
A
T
G
P
W
V
K
Q
-----
F
-
F
D
--
D
-
G
M
H
L
PSP
Y
G
I
R
L
I
K
G
S
H
I
V
V
P
R
V
H
--
T
---------
Q
K
Q
A
Y
I
-
L
--
Q
--
N
--
E
--
D
--
K
R
I
V
-
F
---
V
I
P
W
M
-
D
-
E
F
-
S
I
I
G
T
T
--
D
V
E
Y
-
K
------------------
G
--------------
D
--
P
K
A
V
K
I
E
E
S
E
I
N
Y
L
L
N
V
Y
N
-
T
H
F
K
K
-
Q
L
S
R
D
D
I
V
W
T
Y
S
--
G
V
R
P
L
C
-----------
D
D
------
E
S
D
S
P
Q
A
I
T
R
D
Y
T
L
D
I
H
D
-
E
N
--
G
K
A
P
L
L
S
V
F
G
--
G
---
K
---
L
T
T
Y
R
K
L
A
E
H
A
L
E
K
L
T
P
Y
Y
-
Q
G
I
G
P
A
W
----
T
K
E
S
V
L
P
G
G
A
I
E
G
D
R
------
D
D
Y
A
--
A
R
L
R
R
R
Y
P
F
L
T
E
S
L
A
R
H
Y
A
R
T
Y
G
S
N
S
E
L
L
L
G
N
A
G
T
V
S
--
D
L
G
E
-
D
F
G
H
E
F
Y
E
A
E
L
K
Y
L
V
D
H
E
W
V
R
R
A
D
D
A
L
W
R
R
T
---------------------------------------------------------
7
PsiBlast_PDB
60.69
30%
-32
- C2 -
2R4E
20
GLPD_ECOLI
A:
[27-471]
--------------------------------------------
L
-
S
-
V
L
M
L
E
A
Q
-
D
L
--
A
C
--
A
T
S
S
A
S
S
K
--
L
I
H
G
G
L
R
Y
L
----
E
-
H
Y
E
F
R
L
V
S
E
A
L
A
E
R
E
V
L
L
K
M
A
P
-----
H
I
-
A
F
P
M
R
F
R
L
P
-
H
R
P
H
----
L
---
R
P
A
W
M
I
R
-
I
G
L
F
----
M
Y
D
H
L
G
--------------
K
R
T
-
S
L
P
G
S
T
G
L
R
F
G
A
N
S
V
L
K
P
----
E
----
I
K
R
G
F
E
Y
-
S
D
-
C
W
V
---
D
D
A
R
L
V
L
A
N
A
Q
M
V
V
R
K
G
G
E
V
L
T
R
T
R
---
A
T
S
A
R
R
E
N
G
L
W
I
V
E
A
E
D
--
I
D
--
T
G
K
K
Y
S
W
Q
A
R
G
L
V
N
A
T
G
P
W
V
K
Q
-----
F
-
F
D
--
D
-
G
M
H
L
PSP
Y
G
I
R
L
I
K
G
S
H
I
V
V
P
R
V
H
--
T
---------
Q
K
Q
A
Y
I
-
L
--
Q
--
N
--
E
--
D
--
K
R
I
V
-
F
---
V
I
P
W
M
-
D
-
E
F
-
S
I
I
G
T
T
--
D
V
E
Y
-
K
------------------
G
--------------
D
--
P
K
A
V
K
I
E
E
S
E
I
N
Y
L
L
N
V
Y
N
-
T
H
F
K
K
-
Q
L
S
R
D
D
I
V
W
T
Y
S
--
G
V
R
P
L
C
-----------
D
D
------
E
S
D
S
P
Q
A
I
T
R
D
Y
T
L
D
I
H
D
-
E
N
--
G
K
A
P
L
L
S
V
F
G
--
G
---
K
---
L
T
T
Y
R
K
L
A
E
H
A
L
E
K
L
T
P
Y
Y
-
Q
G
I
G
P
A
W
----
T
K
E
S
V
L
P
G
G
A
I
E
G
D
R
------
D
D
Y
A
--
A
R
L
R
R
R
Y
P
F
L
T
E
S
L
A
R
H
Y
A
R
T
Y
G
S
N
S
E
L
L
L
G
N
A
G
T
V
S
--
D
L
G
E
-
D
F
G
H
E
F
Y
E
A
E
L
K
Y
L
V
D
H
E
W
V
R
R
A
D
D
A
L
W
R
R
T
---------------------------------------------------------
4
PsiBlast_PDB
60.40
30%
-29
- C2 -
2QCU
24
GLPD_ECOLI
A:
[27-471]
--------------------------------------------
L
-
S
-
V
L
M
L
E
A
Q
-
D
L
--
A
C
--
A
T
S
S
A
S
S
K
--
L
I
H
G
G
L
R
Y
L
----
E
-
H
Y
E
F
R
L
V
S
E
A
L
A
E
R
E
V
L
L
K
M
A
P
-----
H
I
-
A
F
P
M
R
F
R
L
P
-
H
R
P
H
----
L
---
R
P
A
W
M
I
R
-
I
G
L
F
----
M
Y
D
H
L
G
--------------
K
R
T
-
S
L
P
G
S
T
G
L
R
F
G
A
N
S
V
L
K
P
----
E
----
I
K
R
G
F
E
Y
-
S
D
-
C
W
V
---
D
D
A
R
L
V
L
A
N
A
Q
M
V
V
R
K
G
G
E
V
L
T
R
T
R
---
A
T
S
A
R
R
E
N
G
L
W
I
V
E
A
E
D
--
I
D
--
T
G
K
K
Y
S
W
Q
A
R
G
L
V
N
A
T
G
P
W
V
K
Q
-----
F
-
F
D
--
D
-
G
M
H
L
PSP
Y
G
I
R
L
I
K
G
S
H
I
V
V
P
R
V
H
--
T
---------
Q
K
Q
A
Y
I
-
L
--
Q
--
N
--
E
--
D
--
K
R
I
V
-
F
---
V
I
P
W
M
-
D
-
E
F
-
S
I
I
G
T
T
--
D
V
E
Y
-
K
------------------
G
--------------
D
--
P
K
A
V
K
I
E
E
S
E
I
N
Y
L
L
N
V
Y
N
-
T
H
F
K
K
-
Q
L
S
R
D
D
I
V
W
T
Y
S
--
G
V
R
P
L
C
-----------
D
D
------
E
S
D
S
P
Q
A
I
T
R
D
Y
T
L
D
I
H
D
-
E
N
--
G
K
A
P
L
L
S
V
F
G
--
G
---
K
---
L
T
T
Y
R
K
L
A
E
H
A
L
E
K
L
T
P
Y
Y
-
Q
G
I
G
P
A
W
----
T
K
E
S
V
L
P
G
G
A
I
E
G
D
R
------
D
D
Y
A
--
A
R
L
R
R
R
Y
P
F
L
T
E
S
L
A
R
H
Y
A
R
T
Y
G
S
N
S
E
L
L
L
G
N
A
G
T
V
S
--
D
L
G
E
-
D
F
G
H
E
F
Y
E
A
E
L
K
Y
L
V
D
H
E
W
V
R
R
A
D
D
A
L
W
R
R
T
---------------------------------------------------------
6
PsiBlast_PDB
58.91
30%
-30
- C2 -
2R46
23
GLPD_ECOLI
A:
[27-471]
--------------------------------------------
L
-
S
-
V
L
M
L
E
A
Q
-
D
L
--
A
C
--
A
T
S
S
A
S
S
K
--
L
I
H
G
G
L
R
Y
L
----
E
-
H
Y
E
F
R
L
V
S
E
A
L
A
E
R
E
V
L
L
K
M
A
P
-----
H
I
-
A
F
P
M
R
F
R
L
P
-
H
R
P
H
----
L
---
R
P
A
W
M
I
R
-
I
G
L
F
----
M
Y
D
H
L
G
--------------
K
R
T
-
S
L
P
G
S
T
G
L
R
F
G
A
N
S
V
L
K
P
----
E
----
I
K
R
G
F
E
Y
-
S
D
-
C
W
V
---
D
D
A
R
L
V
L
A
N
A
Q
M
V
V
R
K
G
G
E
V
L
T
R
T
R
---
A
T
S
A
R
R
E
N
G
L
W
I
V
E
A
E
D
--
I
D
--
T
G
K
K
Y
S
W
Q
A
R
G
L
V
N
A
T
G
P
W
V
K
Q
-----
F
-
F
D
--
D
-
G
M
H
L
PSP
Y
G
I
R
L
I
K
G
S
H
I
V
V
P
R
V
H
--
T
---------
Q
K
Q
A
Y
I
-
L
--
Q
--
N
--
E
--
D
--
K
R
I
V
-
F
---
V
I
P
W
M
-
D
-
E
F
-
S
I
I
G
T
T
--
D
V
E
Y
-
K
------------------
G
--------------
D
--
P
K
A
V
K
I
E
E
S
E
I
N
Y
L
L
N
V
Y
N
-
T
H
F
K
K
-
Q
L
S
R
D
D
I
V
W
T
Y
S
--
G
V
R
P
L
C
-----------
D
D
------
E
S
D
S
P
Q
A
I
T
R
D
Y
T
L
D
I
H
D
-
E
N
--
G
K
A
P
L
L
S
V
F
G
--
G
---
K
---
L
T
T
Y
R
K
L
A
E
H
A
L
E
K
L
T
P
Y
Y
-
Q
G
I
G
P
A
W
----
T
K
E
S
V
L
P
G
G
A
I
E
G
D
R
------
D
D
Y
A
--
A
R
L
R
R
R
Y
P
F
L
T
E
S
L
A
R
H
Y
A
R
T
Y
G
S
N
S
E
L
L
L
G
N
A
G
T
V
S
--
D
L
G
E
-
D
F
G
H
E
F
Y
E
A
E
L
K
Y
L
V
D
H
E
W
V
R
R
A
D
D
A
L
W
R
R
T
---------------------------------------------------------
105
HHSearch
53.03
19%
-55
- C2 -
1RYI
2
GLOX_BACSU
A:
[15-363]
------------------
K
R
H
Y
E
A
V
V
I
G
G
G
I
I
G
S
A
I
A
Y
Y
L
A
K
E
N
K
-
N
-
T
A
L
F
E
S
G
-
T
M
--
G
G
--
R
T
T
S
A
A
A
G
--
M
L
G
A
H
A
E
C
E
----
E
R
D
A
F
F
D
F
A
M
H
S
Q
R
L
Y
K
G
L
G
E
E
L
Y
A
L
SGV
D
I
R
Q
H
N
G
G
M
F
K
L
A
F
S
E
E
------------
D
V
L
----
Q
-----
L
R
Q
M
D
---
D
L
--------
D
S
V
S
-
W
Y
S
K
E
E
V
L
--
E
K
E
P
Y
A
S
G
--------
D
I
F
G
A
S
F
I
-
Q
D
D
V
H
V
---
E
P
Y
F
V
C
K
A
Y
V
K
A
A
K
M
L
G
A
E
I
F
E
H
T
P
---
V
L
H
V
E
R
D
-
G
E
-
A
L
F
I
K
T
--
P
S
------
G
D
V
W
A
N
H
V
V
V
A
S
G
V
W
S
G
M
F
F
K
Q
L
G
-
L
-----
N
N
A
F
------
L
P
V
K
G
E
C
L
S
V
W
N
D
D
I
-
P
---------
L
-
T
K
T
L
-
Y
--------------
H
D
H
C
-
Y
---
I
V
P
-
R
K
S
-
G
R
-
L
V
V
G
A
T
--
M
K
P
G
-
D
--------------------------------
W
S
--
E
T
P
D
---
L
G
G
L
E
S
V
M
K
K
A
K
-
T
M
L
P
A
--
I
Q
N
M
K
V
D
R
F
W
A
--
G
L
R
P
G
T
-----------
K
D
------
G
K
P
---
Y
I
G
R
------
H
P
-
E
---
D
-
S
R
I
L
F
A
A
G
--
H
FRN
G
---
I
L
L
A
P
A
T
G
A
L
I
S
D
L
I
M
N
K
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
109
HHSearch
47.50
15%
-42
- C2 -
3DME
4
?
A:
[3-368]
-------------------
T
D
I
D
C
I
V
I
G
A
G
V
V
G
L
A
I
A
R
A
L
A
A
G
G
H
-
E
-
V
L
V
A
E
A
A
E
G
I
--
G
T
--
G
T
S
S
R
N
S
E
--
V
I
H
A
G
I
Y
Y
P
----
A
D
S
L
K
A
R
L
C
V
R
G
K
H
L
L
Y
E
Y
C
A
A
R
G
-----
V
P
-
H
Q
R
L
G
K
L
I
V
A
T
S
D
A
------------
E
A
S
-
Q
L
D
S
----
I
A
R
R
A
G
A
-
N
G
V
--------
D
D
L
Q
-
H
I
D
G
A
A
A
R
--
R
L
E
P
A
L
H
----------
C
T
A
A
L
V
S
-
P
S
T
G
I
V
---
D
S
H
A
L
M
L
A
Y
Q
G
D
A
E
S
D
G
A
Q
L
V
F
H
T
P
---
L
I
A
G
R
V
R
-
P
E
G
G
F
E
L
D
F
--
G
G
---
A
E
P
M
T
L
S
C
R
V
L
I
N
A
A
G
L
H
A
P
G
L
A
R
R
I
E
G
I
P
RD
S
-
I
P
P
E
------
Y
L
C
K
G
S
Y
F
T
L
A
G
R
A
P
-
F
-----------
S
R
L
I
-
Y
--
P
--
V
--
P
QH
A
--
G
L
G
V
-
H
---
L
T
L
-
D
L
G
-
G
Q
-
A
K
F
G
P
D
--
T
E
W
I
-
A
-------------------------------
T
E
D
--
Y
T
L
D
---
P
R
R
A
D
V
F
Y
A
A
V
R
-
S
Y
W
P
A
--
L
P
D
G
A
L
A
P
G
Y
T
--
G
I
R
P
K
I
-----------
S
G
PHEPAA
D
F
A
---
I
A
G
P
------
A
S
H
G
---
V
-
A
G
L
V
N
L
Y
G
--
I
ESP
G
---
L
T
A
S
L
A
I
A
E
E
T
L
A
R
L
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
106
HHSearch
46.56
17%
-38
- C2 -
1Y56
4
?
B:
[3-356]
------------------
P
E
K
S
E
I
V
V
I
G
G
G
I
V
G
V
T
I
A
H
E
L
A
K
R
G
E
-
E
-
V
T
V
I
E
K
R
-
F
I
--
G
S
--
G
S
T
F
R
C
G
T
--
G
I
R
Q
Q
F
--
N
----
D
-
E
A
N
V
R
V
M
K
R
S
V
E
L
W
K
K
Y
S
E
E
Y
G
-----
F
S
-
F
K
Q
T
G
Y
L
F
L
L
Y
D
D
E
----
E
--------
V
K
-
T
F
K
R
----
N
I
E
I
Q
N
K
--
F
G
--------
V
P
T
K
-
L
I
T
P
E
E
A
K
--
E
I
V
P
L
L
D
I
----
S
---
E
V
I
A
A
S
W
N
-
P
T
D
G
K
A
---
D
P
F
E
A
T
T
A
F
A
V
K
A
K
E
Y
G
A
K
L
L
E
Y
T
E
---
V
K
G
F
L
I
E
-
N
N
E
I
K
G
V
K
T
--
N
K
------
G
I
I
K
T
G
I
V
V
N
A
T
N
A
W
A
N
L
I
N
A
M
A
G
-
I
K
--
T
-
K
I
P
I
------
E
P
Y
K
H
Q
A
V
I
T
Q
P
I
K
R
-
G
---------
T
I
N
P
M
V
-
I
--
S
--
F
-----
K
--
Y
G
H
A
-
Y
---
L
T
Q
-
T
F
H
-
G
G
-
I
I
G
G
I
G
--
Y
E
I
G
-
P
-------------------------------
T
Y
D
--
L
T
P
T
---
Y
E
F
L
R
E
V
S
Y
Y
F
T
-
K
I
I
P
A
--
L
K
N
L
L
I
L
R
T
W
A
--
G
Y
Y
A
K
T
-----------
P
D
------
S
N
P
---
A
I
G
R
------
I
E
-
E
---
L
-
N
D
Y
Y
I
A
A
G
--
F
SGH
G
---
F
M
M
A
P
A
V
G
E
M
V
A
E
L
I
T
K
G
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
117
HHSearch
46.55
13%
-46
- C2 -
2UZZ
2
MTOX_ECOLI
A:
[2-358]
--------------------
K
Y
D
L
I
I
I
G
S
G
S
V
G
A
A
A
G
Y
Y
A
T
R
A
G
L
-
N
-
V
L
M
T
D
A
H
-
M
P
--
P
H
QH
G
S
H
H
G
D
T
R
--
L
I
R
H
A
Y
G
E
-----
G
-
E
K
Y
V
P
L
V
L
R
A
Q
M
L
W
D
E
L
S
R
H
N
E
DD---
P
I
-
F
V
R
S
G
V
I
N
L
G
P
A
D
S
---------
T
--
F
L
A
----
N
----
V
A
H
S
A
E
Q
--
W
Q
--------
L
N
V
E
-
K
L
D
A
Q
G
I
M
--
A
R
W
P
E
I
R
V
----
P
---
D
N
Y
I
G
L
F
E
-
T
D
S
G
F
L
---
R
S
E
L
A
I
K
T
W
I
Q
L
A
K
E
A
G
C
A
Q
L
F
N
C
P
---
V
T
A
I
R
H
D
-
D
D
-
G
V
T
I
E
T
--
A
D
------
G
E
Y
Q
A
K
K
A
I
V
C
A
G
T
W
V
K
D
L
L
P
E
----------
L
P
V
------
Q
P
V
R
K
V
F
A
W
Y
Q
A
D
G
R
Y
S
VK-------
N
K
F
P
A
F
-
T
G
-
E
--
L
--
P
--
N
--
G
D
Q
Y
-
Y
---
G
F
P
-
A
E
N
-
D
A
-
L
K
I
G
K
H
--
N
G
G
Q
-
V
I
-----------------
H
---
S
--------
A
D
E
--
R
V
P
F
AEV
V
S
D
G
S
E
A
F
P
F
L
R
-
N
V
L
P
G
--
I
G
--
C
C
L
Y
G
A
A
--
C
T
Y
D
N
S
-----------
P
D
------
E
D
F
---
I
I
D
T
------
L
P
-
G
---
H
-
D
N
T
L
L
I
T
G
--
L
SGH
G
---
F
K
F
A
S
V
L
G
E
I
A
A
D
F
A
Q
D
K
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
108
HHSearch
44.73
14%
-33
- C2 -
1PJ5
3
DMGO_ARTGO
A:
[4-425]
--------------------
T
P
R
I
V
I
I
G
A
G
I
V
G
T
N
L
A
D
E
L
V
T
R
G
W
-
N
N
I
T
V
L
D
Q
G
-
P
L
NM
P
G
--
G
S
T
S
H
A
P
G
--
L
V
F
Q
T
N
P
------
S
-
K
T
M
A
S
F
A
K
Y
T
V
E
K
L
L
S
L
T
E
D
G
V
-----
S
C
-
F
N
Q
V
G
G
L
E
V
A
T
T
E
T
------------
R
L
A
-
D
L
K
R
----
K
L
G
Y
A
A
A
--
W
G
--------
I
E
G
R
-
L
L
S
P
A
E
C
Q
--
E
L
Y
P
L
L
D
G
----
E
---
N
I
L
G
G
L
H
V
-
P
S
D
G
L
A
---
S
A
A
R
A
V
Q
L
L
I
K
R
T
E
S
A
G
V
T
Y
R
G
S
T
T
---
V
T
G
I
E
Q
S
-
G
G
R
V
T
G
V
Q
T
--
A
D
------
G
V
I
P
A
D
I
V
V
S
C
A
G
F
W
G
A
K
I
G
A
M
I
G
-
M
-----
A
V
P
L
------
L
P
L
A
H
Q
Y
V
K
T
T
P
V
P
A
-
Q
QGRNDQPNG
A
R
L
P
I
L
-
R
-----
H
--
Q
--
D
---
Q
D
L
-
Y
---
Y
R
E
-
H
-
G
-
D
R
-
Y
G
I
G
S
Y
--
A
H
R
P
-
M
P
V
DVDTLGAYAPETVSEH
H
---
M
--------
P
S
R
--
L
D
F
T
---
L
E
D
F
L
P
A
W
E
A
T
K
-
Q
L
L
P
A
--
L
A
D
S
E
I
E
D
G
F
N
--
G
I
F
S
F
T
-----------
P
D
------
G
G
P
---
L
L
G
E
------
S
K
-
E
L
----
D
G
F
Y
V
A
E
A
--
V
---
W
---
V
T
H
S
A
G
V
A
K
A
M
A
E
L
L
T
T
G
R
----
S
E
----
T
D
L
G
E
C
D
I
T
R
F
E
D
V
Q
L
T
-----------------
P
E
Y
V
S
E
T
S
-
Q
Q
N
F
V
E
I
Y
D
V
L
H
P
L
Q
P
R
L
----------------------------------------------------------------------------------------------------
125
Fugue
44.47
17%
-34
- C2 -
3DME
4
?
A:
[3-368]
-------------------
T
D
I
D
C
I
V
I
G
A
G
V
V
G
L
A
I
A
R
A
L
A
A
G
G
H
-
E
-
V
L
V
A
E
A
A
E
G
I
--
G
T
--
G
T
S
S
R
N
S
E
--
V
I
H
A
G
I
Y
Y
P
----
A
-
D
S
L
K
A
R
L
C
V
R
G
K
H
L
L
Y
E
Y
C
A
A
R
-----
G
V
-
P
H
Q
---------------
R
---
L
G
K
L
I
V
A
-
T
S
D
A
----
E
A
S
Q
L
D
S
I
A
R
R
--------
A
G
A
N
-
G
V
D
D
L
Q
H
I
--
D
G
A
A
A
R
R
L
----
E
P--
A
L
H
C
T
A
A
L
-
V
S
-
P
S
T
G
I
V
D
S
H
A
L
M
L
A
Y
Q
G
D
A
E
S
D
G
A
Q
L
V
F
H
T
P
---
L
I
A
G
R
V
R
P
E
----
G
G
F
E
--
L
D
F
G
G
A
E
P
M
T
L
S
C
R
V
L
I
N
A
A
G
L
H
A
P
G
L
A
R
R
I
E
-
G
I
--
P
-
R
D
S
I
P
P
E
---
Y
L
C
K
G
S
Y
F
T
L
A
G
-
R
A
-
P
---------
F
S
R
L
I
Y
P
V
--
P
--
Q
--
H
--
A
--
G
L
G
V
H
L
---
T
L
D
-
L
-
G
-
G
Q
-
A
K
F
G
P
D
--
T
E
W
I
-
A
------------------
T
---
E
----------
D
--
Y
T
L
D
---
P
R
R
A
D
V
F
Y
A
A
V
R
-
S
Y
W
P
A
--
L
P
D
G
A
L
A
P
G
Y
T
--
G
I
R
P
K
I
-----------
S
G
------
P
H
E
P
A
A
D
F
A
I
------
A
G
-
P
A
S
H
G
V
A
G
L
V
N
L
Y
G
--
I
---
E
SPG
L
T
A
S
L
A
I
A
E
E
T
L
A
R
L
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
44.06
23%
-39
- C3 -
4X9M
3
Y051_MYCPN
A:
[36-356]
-------------------
E
T
R
D
V
L
I
V
G
G
G
V
I
G
C
A
T
A
Y
E
L
S
Q
Y
K
L
-
K
-
V
T
L
V
E
K
H
-
H
Y
L-
A
Q
--
E
T
S
H
A
N
S
G
--
V
I
H
T
G
I
D
P
N
----
P
-
H
K
L
T
A
K
Y
N
I
L
G
K
K
L
--------------------
W
L
N
T
Y
F
K
R
L
G
F
P
R
Q
K
---
I
R
T
L
I
V
A
-
F
N
E
M
----
E
R
E
Q
L
E
V
L
K
Q
R
G
I
A
N
QINL
E
D
I
Q
-
M
L
S
K
E
E
T
L
--
K
L
E
P
Y
V
N
P
----
E
IV
A
G
L
K
I
E
G
S
W
A
I
D
-
P
V
L
---
A
S
K
C
L
A
L
A
A
Q
Q
N
K
V
Q
I
C
T
N
T
-----------
E
V
T
N
I
S
K
Q
V
D
G
T
Y
L
V
W
T
N
N
E
T
T
P
S
F
K
V
K
--
K
I
I
D
A
A
G
H
Y
A
D
Y
L
A
H
L
A
K
-
A
D
--
D
-
F
E
Q
-------
T
T
R
R
G
Q
Y
V
V
V
T
N
Q
G
E
-
L
---------
H
L
N
S
M
V
-
F
--
M
--
V
--
P
--
T
IH
G
K
G
V
-
I
---
V
S
P
-
M
L
D
-
G
N
-
F
L
V
G
P
T
A
L
D
G
V
D
-
K
------------------
E
---
A
--------
T
-----
R
Y
I
---
T
K
D
A
P
C
M
L
T
K
I
G
K
H
M
V
P
S
L
N
I
N
N
A
L
I
--
S
F
A
--
G
S
R
P
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
111
HHSearch
43.70
13%
-38
- C2 -
3DJE
2
?
A:
[4-385]
------------------
T
K
S
S
S
L
L
I
V
G
A
G
T
W
G
T
S
T
A
L
H
L
A
R
R
G
Y
T
N
-
V
T
V
L
D
P
Y
-
P
V
--
P
S
--
A
I
S
A
G
N
D
V
N
K
V
I
S
S
G
Q
Y
S
N
N
K
D
E
I
-
E
V
N
E
I
L
A
E
E
A
F
N
G
W
K
N
D
P
L
F
-
K
-----
P
Y
-
Y
H
D
T
G
L
L
M
S
A
C
S
Q
E
------------
G
L
D
-
R
L
G
V
----
R
V
R
P
G
E
---
D
P
--------
N
L
V
E
-
L
T
R
P
E
Q
F
R
--
K
L
A
P
E
G
V
L
QGDF
P
---
G
W
K
G
Y
F
A
R
-
S
G
A
G
W
A
---
H
A
R
N
A
L
V
A
A
A
R
E
A
Q
R
M
G
V
K
F
V
T
G
T
P
QGR
V
V
T
L
I
F
E
-
N
N
D
V
K
G
A
V
T
--
A
D
G
-----
K
I
W
R
A
E
R
T
F
L
C
A
G
A
S
A
G
Q
F
L
D
F
---------
K
N
Q
L
------
R
P
T
A
W
T
L
V
H
I
A
L
K
P
E
-
E
RALY-----
K
N
I
P
V
I
-
F
--
N
-----
I
-----
E
R
G
F
-
F
---
F
E
P
-
D
E
E
R
G
E
-
I
K
I
C
D
E
--
H
P
G
Y
-
T
------------------
N
M
V
Q
S
ADG
T
M
M
S
I
P
F
E
K
-
T
Q
I
P
---
K
E
A
E
T
R
V
R
A
L
L
K
-
E
T
M
P
Q
--
L
A
D
R
P
F
S
F
A
R
I
--
C
W
C
A
D
T
-----------
A
N
------
R
E
F
---
L
I
D
R
------
H
P
-
Q
Y
----
H
S
L
V
L
G
C
G
--
A
SGR
G
---
F
K
Y
L
P
S
I
G
N
L
I
V
D
A
M
E
G
K
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
119
HHSearch
43.58
15%
-44
- C2 -
2OLN
3
?
A:
[3-375]
-------------------
E
S
Y
D
V
V
V
V
G
G
G
P
V
G
L
A
T
A
W
Q
V
A
E
R
G
H
-
R
-
V
L
V
L
E
R
H
-
T
F
--
F
N
EN
G
G
T
S
G
A
E
R
--
H
W
R
--
L
Q
Y
T
----
Q
-
E
D
L
F
R
L
T
L
E
T
L
P
L
W
R
A
L
E
S
R
C
E
R----
R
L
-
I
H
E
I
G
S
L
W
F
G
D
T
D
V
----
V
---
T
N
---
E
G
-
Q
I
S
G
----
T
A
A
M
M
D
K
--
L
S
--------
V
R
Y
E
-
W
L
K
A
T
D
I
E
--
R
R
F
G
F
R
G
L
----
P
---
R
D
Y
E
G
F
L
Q
-
P
D
G
G
T
I
---
D
V
R
G
T
L
A
A
L
F
T
L
A
Q
A
A
G
A
T
L
R
A
G
E
T
---
V
T
E
L
V
P
D
-
A
D
-
G
V
S
V
T
T
--
D
R
------
G
T
Y
R
A
G
K
V
V
L
A
C
G
P
Y
T
N
D
L
L
E
P
L
G
-
A
-----
R
L
A
Y
------
S
V
Y
E
M
A
I
A
A
Y
R
Q
A
T
P
-
V
---------
T
E
A
P
F
W
-
F
A
F
Q
Q
P
T
P-
Q
--
D
--
T
N
L
F
-
Y
G
FG
H
N
P
-
W
A
P
-
G
E
F
V
R
C
G
P
D
--
F
E
V
D
P
L
------------------
D
---
H
--------
P
S
A
AT
G
V
A
D
---
R
R
Q
M
D
R
L
S
G
W
L
R
-
D
H
L
P
T
--
V
D
P
-
D
P
V
R
T
S
T
C
L
A
V
L
P
T
D
-----------
P
E
------
R
Q
F
---
F
L
G
T
------
A
R
-
D
L
M
T
H
G
E
K
L
V
V
-
Y
G
AG
W
---
A
---
F
K
F
V
P
L
F
G
R
I
C
A
D
L
A
V
E
D
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------