@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1431: (2016-03-24 )
MLTVNNVGLRYGDKKLFEDVSIKFLPGNCYGLIGANGAGKSTFLKVLSGELDSQSGNVHIGSGERLAVLRQDHFQYDDELVLNTVIMGHERLYKIMDEKNAIYMKEDFSDEDGIRAAELEGEFAELDGWEAESDAAVLLNGLGIPTDLHGKLMKDLTGGEKVKVLLAQALFGKPDILLLDEPTNHLDIRAIHWLEEFLINFDNTVIVVSHDRHFLNKVCTHIADLDFSKIKLYVGNYDFWYESSQLAQTMMGDRNKKKEEKMKELQDFIARFSANASKSKQATSRKKMLEKITLEDIQPSSRRYPFIQFKPDREVGNDLLTVTNLSKTIDGVKILDNLSFSINRNDKVALVGDDEVAKTVLFQILAGEMEPDEGSYKWGITTSQSYFPKDNSEFFEENDMSLVEWLRQFSPEDDSEAFLRGFLGRMLFSGDEVLKKVRVLSGGEKVRCMLSKMMLSGSNVLLLDEPTNHLDLESITALNNGLEAFKGAIIFASHDHQLLQTIATRIINLSKDQFYNKEISYDEYLKEVMNVAE
Atome Classification :
(20 SA)
---------------------------------------------------------------.........10.-.-------.-.-....20...-------------....-.30........40.....-------...-------50--------....--.--...60.--------------.--...--...70...-.--------------.-.--..-.80..--......90........100.......110.......120-----.....----...130.......140.......150.......160.......170.......180.......-------190-.........200--.----..---......210.......220.......230..-----.....240.--......250.......260.......270.......280.......290.......300...-----....310.......320.......330-........340.....-----..350.......360.-......370.......380........390.....-..400.------------------------------------------------------------------......----410----------------------------------...-----..-------....420.......430-.......440.......450.......460.......470..----.....480---.----...----..---.----.490......-.500....-...----510-.......520-.-...-....530.---------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------------------------------------------------------------
M
L
T
VNNVGLRYG-
D
-------
K
-
K
-
L
F
E
DV
S
I
K
F-------------LPGN-
C
Y
G
L
IGANGA
G
K
S
T
F
L
K
V
-------
L
SG-------EL--------DSQS--G--
N
V
H
IGS--------------G--
E
R
L
--
A
V
L
R
-
Q
DH-F--------------Q-Y--
D
D
-
E
L
V
L
N
--
T
V
IM
G
H
E
R
L
Y
K
I
MDEKN
A
I
Y
MKEDFSDEDG
I
R
A
A
E
LEG------EFAEL----DGWEAESD
A
A
V
L
L
NGLGIP
T
D
L
H
G
K
L
M
K
D
LTG
G
E
K
V
K
V
L
L
A
Q
A
LFGKP
D
I
L
L
LDEPTNHL
D
I
R
-------
A
---
I
H
W
L
E
E
F
L
IN----F----D
N
---
T
V
I
V
V
SH
D
R
H
F
L
N
K
V
C
T
H
I
ADLD
F
S
K
I
K
L
Y
V-----GN
Y
D
F
WY
E
S
--
S
Q
L
A
Q
T
M
MGDRN
K
K
K
E
E
K
M
K
E
L
Q
D
F
I
A
R
FSANASK
S
K
Q
A
T
S
R
K
K
M
L
E
K
I
T
L
EDIQPSSRRY
P
-----
F
I
Q
FKPDREVGN
D
L
L
T
VT
N
L
S
K
TIDG--
V
K
I
LDN
L
S
F
S
INRN
D
K
-----
V
A
L
VG
D
D
E
V
A
K
T
V
L
F
Q
-
I
L
AGEMEPDEG
S
Y
K
WGI-TTSQSYFPKD
N
S
E
F
FEE-ND
M
S
L
V
------------------------------------------------------------------
E
W
L
R
QF----S------------------------------------PED-----
D
S
-------
E
A
F
L
R
G
F
L
G
R
MLF
S
G
D
E
-
V
L
K
K
V
R
VLSG
G
E
K
V
R
C
M
L
S
K
M
M
LSGS
N
V
L
L
LDEPTNHL
D
L
E
S
----
I
T
A
L
N
N
G
----
L
----
E
A
F----K
G
---
A
----
I
I
F
ASH
D
H
Q
L
-
L
Q
T
I
A
T
R
I
-INL----
S
K
D
-QFYNKEI
S
-
Y
-
D
-
E
Y
L
-
K
E
V
M
N
VAE---------------------------------------
1
PsiBlast_PDB
76.40
32%
-57
- C1 -
3J5S
-
ETTA_ECOLI
D:
[13-546]
-----------------------------------------------------------------
T
M
H
R
V
G
K
V
V
P
-
P
-------
K
-
R
H
I
L
K
N
I
S
L
S
F
-------------
F
P
G
A
-
K
I
G
V
L
G
L
N
G
A
G
K
S
T
L
L
R
I
-------
M
A
G
IDKDIEG
E
A
--------
R
P
Q
P
-----
D
I
K
I
G
Y
--------------
L
--
P
Q
E
--
P
Q
L
N
-
P
E
H
-
T
--------------
V
-
R
--
E
S
I
E
E
A
V
S
--
E
V
V
N
A
L
K
R
L
----
D
E
V
Y
A
L
Y
A
D
P
D
-
A
D
F
D
K
L
-
A
A
E
-
Q
G
------
R
L
E
E
I
IQAH
D
G
H
N
L
N
V
Q
L
E
R
A
A
D
A
L
R
L
P
-
D
W
D
A
K
I
A
-
N
L
S
G
G
E
R
R
R
V
A
L
C
R
L
L
L
E
K
P
D
M
L
L
L
D
E
P
T
N
H
L
D
A
E
-------
S
---
V
A
W
L
E
R
F
L
H
D
----
F
----
E
G
---
T
V
V
A
I
T
H
D
R
Y
F
L
D
N
V
A
G
W
I
L
E
L
D
R
G
E
G
I
P
W
E
-----
G
N
Y
S
S
W
L
E
Q
KD
Q
R
L
A
Q
E
A
S
Q
E
A
A
R
R
K
S
I
E
-
K
E
L
E
W
V
R
Q
G
T
K
G
R
Q
S
K
G
K
A
R
L
A
R
F
E
E
L
N
S
T
E
Y
Q
K
R
N
E
T
N
E
L
F
---------
I
P
P
G
P
R
L
G
D
K
V
L
E
V
S
N
L
R
K
S
Y
G
D
--
R
L
L
I
D
D
L
S
F
S
I
P
K
G
A
I
-----
V
G
I
I
G
P
N
G
A
G
K
S
T
L
F
R
-
M
I
S
G
Q
E
Q
P
D
S
G
T
I
T
L
G
E
-
T
V
K
L
A
S
V
----
D
Q
F
R
D
S
-
M
D
N
S
K
T
------------------------------------------------------------------
V
W
E
E
V
S
----
G
------------------------------------
G
L
D
IMKIG
N
T
-------
E
M
P
S
R
A
Y
V
G
R
F
N
F
K
G
V
D
-
Q
G
K
R
V
G
E
L
S
G
G
E
R
G
R
L
H
L
A
K
L
L
Q
V
G
G
N
M
L
L
L
D
E
P
T
N
D
L
D
I
E
T
----
L
R
A
L
E
N
A
----
L
----
L
E
F
----
P
G
---
C
----
A
M
V
I
S
H
D
R
W
F
-
L
D
R
I
A
T
H
I
-
L
D
Y
QDE-
G
K
V
-
E
F
F
E
G
N
F
T
E
Y
-
E
-
E
Y
K
-
K
R
T
L
G
A
-----------------------------------------
2
PsiBlast_PDB
66.50
32%
-63
- C1 -
4FIN
13
ETTA_ECOLI
A:
[19-540]
------------------------------------------------------------------------------------
R
-
H
-
I
L
K
N
I
S
L
S
F
-------------
F
P
G
A
-
K
I
G
V
L
G
L
N
G
A
G
K
S
T
L
L
R
I
M
A
GIDKD
I
E
G
-------
E
A
--------
R
P
Q
P
-----
D
I
K
I
G
Y
--------------
L
--
P
Q
E
--
P
Q
L
N
-
P
E
H
-
T
--------------
V
-
R
--
E
S
I
E
E
A
V
S
--
E
V
V
N
A
L
K
R
L
----
D
E
V
Y
A
L
Y
A
D
P
D
-
A
D
F
D
K
L
-
A
A
E
-
Q
G
------
R
L
E
E
I
IQ------
L
N
V
Q
L
E
R
A
A
D
A
L
R
L
P
-
D
W
D
A
K
I
A
-
N
L
S
G
G
E
R
R
R
V
A
L
C
R
L
L
L
E
K
P
D
M
L
L
L
D
E
P
T
N
H
L
D
A
E
-------
S
---
V
A
W
L
E
R
F
L
H
D
----
F
----
E
G
---
T
V
V
A
I
T
H
D
R
Y
F
L
D
N
V
A
G
W
I
L
E
L
D
R
G
E
G
I
P
W
E
-----
G
N
Y
S
S
W
L
E
Q
K
D
Q
R
L
A
Q
E
A
S
Q
E
A
A
R
R
K
S
I
E
-
K
E
L
E
W
V
R
Q
G
T
K
----
K
G
K
A
R
L
A
R
F
E
E
L
N
S
T
E
Y
Q
K
R
N
E
T
N
E
L
F
---------
I
P
P
G
P
R
L
G
D
K
V
L
E
V
S
N
L
R
K
S
Y
G
D
--
R
L
L
I
D
D
L
S
F
S
I
P
K
G
A
I
-----
V
G
I
I
G
P
N
G
A
G
K
S
T
L
F
R
-
M
I
S
G
Q
E
Q
P
D
S
G
T
I
T
L
G
E
-
T
V
K
L
A
S
V
----
D
Q
F
R
D
S
-
M
D
N
S
K
T
------------------------------------------------------------------
V
W
E
E
V
S
----
G
------------------------------------
G
L
D
IMKIG
N
T
-------
E
M
P
S
R
A
Y
V
G
R
F
N
F
K
G
V
D
-
Q
G
K
R
V
G
E
L
S
G
G
E
R
G
R
L
H
L
A
K
L
L
Q
V
G
G
N
M
L
L
L
D
E
P
T
N
D
L
D
I
E
T
----
L
R
A
L
E
N
A
----
L
----
L
E
F
----
P
G
---
C
----
A
M
V
I
S
H
D
R
W
F
-
L
D
R
I
A
T
H
I
-
L
D
Y
Q
D
E-
G
K
V
-
E
F
F
E
G
N
F
T
E
Y
-
E
-
E
Y
K
-
K
R
T
L
G
A
-----------------------------------------
7
PsiBlast_PDB
66.43
24%
-66
- C1 -
1YQT
4
?
A:
[47-472]
----------------------------------------------------------------------------------------------------------------
G
M
-
V
V
G
I
V
G
P
N
G
T
G
K
S
T
A
V
K
I
-------
L
A
G
-------
Q
L
IPNLCGDN
D
S
W
D
--
G
--
V
I
R
A
F
R
--------------
G
--
N
E
L
-------
Q
N
Y
-
F
E
K
L
K
N
GE
I
R
P
V
V
KP
Q
-
Y
--
V
D
--
L
I
P
K
--
A
V
K
G
K
V
I
E
L
L
K
K
A
D
E
T
G
K
L
--------
E
E
V
V
K
A
L
E
L
E
------------------------------------
N
V
L
E
R
E
I
Q
H
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
N
A
T
F
Y
F
F
D
E
P
S
S
Y
L
D
I
R
Q
R
L
N
A
A
R
A
---
I
R
R
L
S
E
E
------------
G
K
---
S
V
L
V
V
E
H
D
L
A
V
L
D
----
Y
L
S
D
I
----
I
H
V
V
Y
-----
G
E
P
G
V
Y
G
I
F
--
S
Q
----
P
K
G
T
R
N
G
I
N
E
F
L
R
G
Y
L
K
D
E
N
V
R
F
R
P
Y
E
I
K
F
T
K
T
G
E
R
V
E
I
----------------------------
E
R
E
T
---
L
V
T
Y
P
R
L
V
K
D
Y
G
S
--
F
R
-
L
E
V
E
P
G
E
I
K
K
G
E
V
-----
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
-
M
L
A
G
V
E
E
P
T
E
G
K
I
E
W
D
L
-
T
V
A
--
Y
K
P
Q
Y
I
K
A
D
Y
E
----
G
T
V
Y
------------------------------------------------------------------
E
L
L
S
K
I
----
D
------------------------------------
A
S
K
-----
L
N
-------
S
N
F
Y
K
T
E
L
L
K
P
L
G
I
I
D
L
-
Y
D
R
E
V
N
E
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
A
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
----
R
L
A
V
S
R
A
----
I
R
H
L
M
E
K
N
----
E
K
---
T
----
A
L
V
V
E
H
D
V
L
M
-
I
D
Y
V
S
D
R
L
----------------------------------------------------------------------------
24
HHSearch
62.88
21%
-73
* C1 *
1YQT
4
?
A:
[25-477]
-------------------------------------------------------------------
E
D
C
V
H
R
Y
G
-
V
N------
A
-
F
-
V
L
Y
R
L
P
-
V
V
-------------
K
E
G
M
-
V
V
G
I
V
G
P
N
G
T
G
K
S
T
A
V
K
I
-------
L
A
G
-------
Q
L
--------
I
P
N
L
CG
D
--
N
D
S
W
D
G
--------------
V
--
I
R
A
F
R
G
N
E
L
-
Q
N
Y
F
E
--------------
K
-
L
--
K
N
-
G
E
I
R
P
--
V
V
K
P
Q
Y
V
D
L
I
P
---
K
---
A
------------
V
K
G
K
V
I
---------
E
L
L
----
K
K
A
D
E
T
G
K
L
E
E
V
V
K
A
L
E
L
E
-
N
V
L
E
R
E
I
Q
H
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
N
A
T
F
Y
F
F
D
E
P
S
S
Y
L
D
I
R
-------
Q
---
R
L
N
A
A
R
A
I
R
R
----
L
S
E
E
-
G
K
---
S
V
L
V
V
E
H
D
L
A
V
L
D
Y
L
S
D
I
I
H
V
V
Y
G
E
P
----------
G
V
Y
G
I
F
S
Q
P
--
K
G
T
R
N
G
---------------
I
N
E
F
L
R
G
Y
L
K
D
--------
E
N
-
V
R
F
R
P
Y
E
I
K
-
F
T
K
---
T
G
----------
E
R
V
E
I
E
R
E
T
L
V
T
Y
P
R
L
V
K
D
Y
G
S
---
F
R
L
E
V
E
P
G
E
I
K
K
G
E
V
-----
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
-
M
L
A
G
V
E
E
P
T
E
G
K
I
E
W
D
L
---
T
V
A
Y
K
P
Q
Y
I
K
A
D
----
Y
E
G
T
V
Y
------------------------------------------------------------------
E
L
L
S
K
I
----
D
------------------------------------
A
S
K
L
----
N
S
-------
N
F
Y
K
T
E
L
L
K
P
L
G
I
I
-
D
L
-
Y
D
R
E
V
N
E
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
A
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
----
R
L
A
V
S
R
A
----
I
----
R
H
L
M
E
K
N
E
K
---
T
----
A
L
V
V
E
H
D
V
L
M
-
I
D
Y
V
S
D
R
L
-
M
V
F
----
E
G
------------------------------------------------------------------
21
HHSearch
61.44
25%
-11
- C- -
2IW3
7
EF3A_YEAST
A:
[440-979]
--------------------------------------------------------------------
E
F
S
L
A
Y
G
-
A
-------
K
-
I
-
L
L
N
K
T
Q
L
R
L
-------------
K
R
A
R
-
R
Y
G
I
C
G
P
N
G
C
G
K
S
T
L
M
R
A
-------
I
A
N
-------
G
Q
--------
V
--
D
--
G
--
F
P
T
Q
-
E
--------------
E
--
C
R
T
--
V
Y
V
E
-
H
D
I
-
D
--------------
G
T
H
--
S
D
-
T
S
V
L
D
--
F
V
F
E
S
G
-------------------------------------------------
V
G
T
K
E
A
I
K
D
K
L
I
E
F
G
F
T
D
E
M
I
A
M
P
I
S
A
L
S
G
G
W
K
M
K
L
A
L
A
R
A
V
L
R
N
A
D
I
L
L
L
D
E
P
T
N
H
L
D
T
V
-------
N
---
V
A
W
L
V
N
Y
L
N
T
----
C
----
G
I
---
T
S
I
T
I
S
H
D
S
V
F
L
D
N
V
C
E
Y
I
I
N
Y
E
G
L
K
L
R
K
Y
K
-----
G
N
F
T
E
F
V
K
K
--
C
P
A
A
K
A
------------
Y
E
E
L
S
N
T
-----------------
D
---
L
E
F
K
F
------
P
--
E
P
-----
G
Y
-
L
E
G
V
K
T
K
Q
K
A
I
V
K
V
T
N
M
E
F
Q
Y
P
G
TS
K
P
Q
I
T
D
I
N
F
Q
C
S
L
S
S
R
-----
I
A
V
I
G
P
N
G
A
G
K
S
T
L
I
N
-
V
L
T
G
E
L
L
P
T
S
G
E
V
Y
T
H
E
-
N
C
R
I
A
Y
I
K
Q
H
A
F
A
H
I
E
S
H
L
D
K
T
P
S
E
Y
I
Q
W
R
F
Q
TGEDRETMDRANRQINEND
A
E
A
M
N
K
I
F
K
I
EG
T
P
R
R
IAGIH
S
R
R
K
F
KN
T
Y
E
Y
E
C
S
F
L
L
G
E
N
I
G
M
K
S
E
R
W
V
P
M
M
SVD
N
A
W
I
P
RGELVESH
S
K
M
V
A
E
V
D
M
K
E
A
L
A
S
GQ
F
R
P
-----
L
T
-------
R
K
E
I
E
E
H
C
S
M
L
G
L
D
P
E
I
V
S
H
S
R
I
R
G
L
S
G
G
Q
K
V
K
L
V
L
A
A
G
T
W
Q
R
P
H
L
I
V
L
D
E
P
T
N
Y
L
D
R
D
S
----
L
G
A
L
S
K
A
----
L
----
K
E
F
----
E
G
---
G
----
V
I
I
I
T
H
S
A
E
F
-
T
K
N
L
T
E
E
V
-
W
A
V
----
K
D
--
G
R
M
T
P
S
----------------------------------------------------------
22
HHSearch
60.56
20%
-75
- C1 -
3BK7
4
?
A:
[84-547]
----------------------------------------------------------------
I
S
I
V
N
L
P
E
Q
L
D
-
E
D
CVHRYG
V
-
N
-
A
F
V
L
Y
R
L
P
I
V
------------
K
D
G
M
-
V
V
G
I
V
G
P
N
G
T
G
K
T
T
A
V
K
I
-------
L
A
G
-------
Q
L
--------
I
P
N
L
--
C
--
E
D
N
D
S
W
--------------
D
---
N
V
--
I
R
A
F
-
R
G
N
-
E
--------------
L
-
Q
--
N
Y
-
F
E
R
L
K
N
G
E
I
R
P
V
V
K
P
Q
Y
--------
V
D
---
L
L
P
K
-
A
V
--
K
G
K
V
R
E
------
L
L
-------
K
K
V
D
E
V
G
K
F
E
E
V
V
K
E
L
E
L
E
-
N
V
L
D
R
E
L
H
Q
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
K
A
H
F
Y
F
F
D
E
P
S
S
Y
L
D
I
R
-------
Q
---
R
L
K
V
A
R
V
I
R
R
----
L
A
N
E
-
G
K
---
A
V
L
V
V
E
H
D
L
A
V
L
D
Y
L
S
D
V
I
H
V
V
Y
G
E
-----
P
-----
G
V
Y
G
I
F
S
K
P
--
K
G
T
R
N
G
I
---------------
N
E
F
L
Q
G
Y
L
K
D
E
------
N
V
R
F
R
P
-
Y
E
I
R
F
------
T
K
L
---------
S
E
-
R
V
D
V
E
R
E
T
L
V
E
Y
P
R
L
V
K
D
Y
G
S
---
F
K
L
E
V
E
P
G
E
I
R
K
G
E
V
-----
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
-
M
L
A
G
V
E
E
P
T
E
G
K
V
E
W
D
L
---
T
V
A
Y
K
P
Q
Y
I
K
A
E
----
Y
E
G
T
V
Y
------------------------------------------------------------------
E
L
L
S
K
I
----
D
------------------------------------
S
S
K
L
----
N
S
-------
N
F
Y
K
T
E
L
L
K
P
L
G
I
I
-
D
L
-
Y
D
R
N
V
E
D
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
A
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
----
R
L
A
V
S
R
A
----
I
----
R
H
L
M
E
K
N
E
K
---
T
----
A
L
V
V
E
H
D
V
L
M
-
I
D
Y
V
S
D
R
L
-
I
V
F
----
E
G
------------------------------------------------------------------
48
Fugue
60.46
19%
-51
- C1 -
3J16
4
RLI1_YEAST
B:
[1-608]
MS
D
K
N
S
R
I
A
I
V
S
ADKCKPKKCRQ
E
C
K
R
S
C
P
V
V
K
T
GKLC
I
E
V
T
PTSK
I
A
F
I
S
EILCIGCG
I
C
V
K
K
C
P
F
D
A
I
Q
I
I
N
L
-
P
-------
T
-
N
-
L
E
A
H
V
T
H
R
Y
SAN
S
F
K
L
H
R
L
P
T
P
R
P
G
Q
-
V
L
G
L
V
G
T
N
G
I
G
K
S
T
A
L
K
I
-------
L
A
G
-------
K
Q
--------
K
P
N
L
--
G
--
R
-
F
D
D
P
--------------
P
--
E
W
Q
--
E
I
I
K
-
Y
---
F
--------------
R
-
G
--
S
E
------------
L
Q
N
Y
F
T
K
M
L
E
D
D
I
K
A
I
I
K
P
Q
Y
V
D
N
---
I
P
R
A
I
K
G
PVQK
V
G
E
L
L
K
L
----
R
M
E
K
S
P
E
D
V
K
R
Y
I
K
I
L
Q
L
E
-
N
V
L
K
R
D
I
E
K
L
S
G
G
E
L
Q
R
F
A
I
G
M
S
C
V
Q
E
A
D
V
Y
M
F
D
E
P
S
S
Y
L
D
V
K
-------
Q
---
R
L
N
A
A
Q
I
I
R
S
----
L
L
A
P
-
T
K
---
Y
V
I
C
V
E
H
D
----
L
S
V
L
D
Y
L
S
D
----
F
V
C
I
I
Y
-----
G
V
P
S
V
Y
G
V
V
--
T
L
---------
P
A
S
V
R
E
G
I
N
I
F
L
D
G
H
I
P
A
E
N
L
R
F
R
T
E
A
L
Q
F
R
I
A
D
A
T
E
D
L
Q
N
D
S
A
S
R
A
F
S
Y
P
-----
S
L
K
K
T
Q
-------------------
G
--
D
F
V
L
N
V
E
E
G
E
F
S
D
S
E
I
-----
L
V
M
M
G
E
N
G
T
G
K
T
T
L
I
K
-
L
L
A
G
A
L
K
P
D
E
G
Q
D
I
P
K
L
-
N
--
V
S
M
K
P
Q
K
I
A
P
K
F
P
G
----
T
V
R
------------------------------------------------------------------
Q
L
F
F
K
K
----
I
------------------------------------
R
G
Q
-----
F
L
-------
N
P
Q
F
Q
T
D
V
V
K
P
L
R
I
D
D
I
-
I
D
Q
E
V
Q
H
L
S
G
G
E
L
Q
R
V
A
I
V
L
A
L
G
I
P
A
D
I
Y
L
I
D
E
P
S
A
Y
L
D
S
E
Q
----
R
I
I
C
S
K
V
----
I
----
R
R
F
----
I
L
---
H
N
K
K
T
A
F
I
V
E
H
D
F
I
M
-
A
T
Y
L
A
D
K
V
-
I
V
F
E
G
I
P
S
K
N
-
A
H
A
R
A
P
E
S
-
L
-
L
-
T
G
C
-
N
R
F
L
K
N
L
N
VTFRRDPNSF
R
P
R
I
N
K
L
DS
Q
M
D
K
E
Q
K
S
S
GNYFFLDNTGI
25
HHSearch
59.26
20%
-70
- C1 -
3OZX
5
?
A:
[4-462]
--------------------------------------------------------------------
E
V
I
H
R
Y
K
-
V
N------
G
-
F
-
K
L
F
G
L
P
T
-
P
-------------
K
N
N
T
-
I
L
G
V
L
G
K
N
G
V
G
K
T
T
V
L
K
I
-------
L
A
G
-------
E
I
--------
I
P
N
F
--
G
--
D
P
N
S
K
V
G
K
D
E
V
L
K
R
F
R----
G
--
K
E
I
--
Y
N
Y
F
-
K
E
L
-
Y
--------------
S
----
N
E
-
L
K
I
V
H
--
K
I
Q
Y
V
E
Y
--------------
A
S
K
F
------
L
K
G
T
V
N
E
------
I
L
-------
T
K
I
D
E
R
G
K
K
D
E
V
K
E
L
L
N
M
T
-
N
L
W
N
K
D
A
N
I
L
S
G
G
G
L
Q
R
L
L
V
A
A
S
L
L
R
E
A
D
V
Y
I
F
D
Q
P
S
S
Y
L
D
V
R
-------
E
---
R
M
N
M
A
K
A
I
R
E
----
L
L
K--
N
K
---
Y
V
I
V
V
D
H
D
L
I
V
L
D
Y
L
T
D
L
I
H
I
I
Y
-
G
E
S
S
V
Y
G
------
R
V
S
K
S
Y
A
A
--
R
V
G
-
I
N
-----------------
N
F
L
K
G
Y
L
P
A
E
N
M
K
I
R
P
D
E
I
K
F
M
L
K
------------------------------
L
K
T
K
M
K
W
T
K
I
I
K
K
L
G
---
D
F
Q
L
V
V
D
N
G
E
A
K
E
G
E
I
-----
I
G
I
L
G
P
N
G
I
G
K
T
T
F
A
R
-
I
L
V
G
E
I
T
A
D
E
G
S
V
T
P
E
K
--
Q
I
L
S
Y
K
P
Q
R
I
F
P
N
----
Y
D
G
T
V
Q
------------------------------------------------------------------
Q
Y
L
E
N
A
----
S
------------------------------------
K
D
A
LS---
T
S
-------
S
W
F
F
E
E
V
T
K
R
L
N
L
H
-
R
L
-
L
E
S
N
V
N
D
L
S
G
G
E
L
Q
K
L
Y
I
A
A
T
L
A
K
E
A
D
L
Y
V
L
D
Q
P
S
S
Y
L
D
V
E
E
----
R
Y
I
V
A
K
A
----
I
----
K
R
V
T
R
E
R
K
A
---
V
----
T
F
I
I
D
H
D
L
S
I
-
H
D
Y
I
A
D
R
I
-
I
V
F
----
K
G
E
-----------------------------------------------------------------
10
PsiBlast_PDB
57.41
22%
-55
- C1 -
3BK7
2
?
A:
[117-543]
----------------------------------------------------------------------------------------------------------------
G
M
-
V
V
G
I
V
G
P
N
G
T
G
K
T
T
A
V
K
I
-------
L
A
G
-------
Q
L
IPNLCEDN
D
S
W
D
--
N
--
V
I
R
A
F
R
--------------
G
--
N
E
L
-------
Q
N
Y
-
F
--------------
E
------------------------
R
L
K
N
G
E
I
R
P
V
V
K
P
Q
Y
V
D
---
L
L
P
K
A
V
K
G
------
K
V
R
E
L
----
L
K
K
V
D
E
V
G
K
F
E
E
V
V
K
E
L
E
L
E
N
V
L
D
R
E
L
H
Q
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
K
A
H
F
Y
F
F
D
E
P
S
S
Y
L
D
I
R
-------
Q
R
L
K
V
A
R
V
I
R
R
L
A
N
----
E
----
G
K
---
A
V
L
V
V
E
H
D
----------
L
A
V
L
D
Y
L
S
D
V
I
H
V
V
Y
G
E
P
G
V
Y
G
I
F
S
K
P
--
K
-------
G
T
R
N
G
I
N
E
F
L
Q
G
Y
L
K
D
E
N
V
R
F
R
P
Y
E
I
R
F
T
K
L
S
E
R
V
D
V
E
R
E
T
L
V
E
--------
Y
P
R
L
V
K
D
Y
G
S
F
K
L
E
V
E
P
G
--------------------------
E
I
R
K
G
E
V
-----
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
-
M
L
A
G
V
E
E
P
T
E
G
K
V
E
W
D
L
-
T
V
--
A
Y
K
P
Q
---
Y
I
K
A
E
-
Y
E
G
T
V
Y
------------------------------------------------------------------
E
L
L
S
K
I
----
D
------------------------------------
S
S
K
-----
L
N
-------
S
N
F
Y
K
T
E
L
L
K
P
L
G
I
I
D
L
-
Y
D
R
N
V
E
D
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
A
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
----
R
L
A
V
S
R
A
I
R
H
L
M
----
E
K
N
----
E
K
---
T
----
A
L
V
V
E
H
D
V
L
M
-
I
D
Y
V
S
D
R
L
-
I
--------------------------------------------------------------------------
45
Fugue
56.51
19%
-53
- C1 -
1YQT
4
?
A:
[24-538]
------------------------------------------------------------------
E
E
D
C
V
H
R
Y
G
-
V
-------
N
-
A
-
F
-
V
L
Y
R
L
P
V
-------------
V
K
E
G
M
V
V
G
I
V
G
P
N
G
T
G
K
S
T
A
V
K
I
-------
L
A
G
-------
Q
L
--------
I
P
N
L
--
C
--
G
D
N
D
S
W
--------------
D
--
G
V
I
--
R
A
F
R
-
G
N
E
-----------------------------------
L
Q
N
Y
F
E
K
L
K
N
G
E
I
R
P
V
V
K
P
Q
Y
V
D
L
I
--
P
K
A
V
K
G
K
------
V
I
E
L
L
----
K
K
A
D
E
T
G
K
L
E
E
V
V
K
A
L
E
L
E
-
N
V
L
E
R
E
I
Q
H
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
N
A
T
F
Y
F
F
D
E
P
S
S
Y
L
D
I
R
-------
Q
---
R
L
N
A
A
R
A
I
R
R
----
L
----
S
E
E
G
K
S
V
L
V
V
E
H
D
L
A
V
L
D
Y
L
S
D
I
I
H
V
V
Y
G
E
P
G
V
Y
G
I
-----
F
S
Q
P
K
G
T
R
N
--
G
I
N
E
F
L
R
------------------------------------
G
Y
L
K
D
E
N
V
R
F
R
P
Y
E
I
K
F
T
K
-----
T
G
E
R
V
E
I
E
R
--
E
T
L
V
T
Y
P
R
L
V
K
D
Y
-
G
--
S
F
R
L
E
V
E
P
G
E
I
K
K
G
E
V
-----
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
M
L
A
-
G
V
E
E
P
T
E
G
K
I
E
W
D
L
T
V
A
Y
K
P
Q
Y
I
K
A
D
Y
E
-------
G
T
V
Y
------------------------------------------------------------------
E
L
L
S
K
I
----
D
------------------------------------
A
S
K
-----
L
N
-------
S
N
F
Y
K
T
E
L
L
K
P
L
G
I
I
D
L
-
Y
D
R
E
V
N
E
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
A
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
----
R
L
A
V
S
R
A
----
I
----
R
H
L
M
---
E
K
N
E
K
T
----
A
L
V
V
E
H
D
-
V
L
M
I
D
Y
V
S
D
R
L
M
V
F
E
----
G
E
P
-
G
K
Y
G
R
A
L
P
-
P
M
G
M
R
E
G
M
N
R
F
L
A
S
I
G
I
T
F
R
R
D
PDTG
R
P
R
A
N
K
EGS
V
K
D
R
E
Q
K
E
K
GEYYYIA----
23
HHSearch
55.74
19%
-52
- C1 -
3J16
2
RLI1_YEAST
B:
[82-559]
--------------------------------------------------------------------
H
V
T
H
R
Y
S
-
A
-------
N
S
F
-
K
L
H
R
L
P
-
T
P
-------------
R
P
G
Q
-
V
L
G
L
V
G
T
N
G
I
G
K
S
T
A
L
K
I
-------
L
A
G
-------
K
Q
--------
K
P
N
L
--
G
--
R
F
D
D
P
P
--------------
E
W
Q
E
I
I
--
K
Y
F
--
R
G
S
-
E
--------------
L
-
Q
N
Y
F
T
-
K
M
L
E
D
--
D
I
K
A
I
I
K
P
Q
Y
V
--
D
N
I
P
R
A
I
K
------
G
---
P
V
Q
K
V
G
E
------
L
L
K
-
L
----
R
M
E
K
S
P
E
D
V
K
R
Y
I
K
I
L
Q
L
E
-
N
V
L
K
R
D
I
E
K
L
S
G
G
E
L
Q
R
F
A
I
G
M
S
C
V
Q
E
A
D
V
Y
M
F
D
E
P
S
S
Y
L
D
V
K
-------
Q
---
R
L
N
A
A
Q
I
I
R
S
----
L
L
A
P
-
T
K
---
Y
V
I
C
V
E
H
D
L
S
V
L
D
Y
L
S
D
F
V
C
I
I
Y
G
V
P
S
----------
V
Y
G
V
V
T
L
P
--
A
S
V
R
E
G
------------
I
---
N
I
F
L
D
G
H
I
P
A
----
E
N
L
R
F
R
T
E
---
A
L
Q
F
R
-
I
A
-----
D
A
-------
T
E
D
L
Q
N
D
S
A
S
R
A
F
S
Y
P
S
L
K
K
T
Q
-
G
--
D
F
V
L
N
V
E
E
G
E
F
S
D
S
E
I
-----
L
V
M
M
G
E
N
G
T
G
K
T
T
L
I
K
-
L
L
A
G
A
L
K
P
D
E
G
Q
D
I
P
---
K
L
N
V
S
M
K
P
Q
K
I
A
P
K
F
----
P
G
T
V
R
------------------------------------------------------------------
Q
L
F
F
K
K
----
I
------------------------------------
R
G
Q
F----
L
N
-------
P
Q
F
Q
T
D
V
V
K
P
L
R
I
D
-
D
I
-
I
D
Q
E
V
Q
H
L
S
G
G
E
L
Q
R
V
A
I
V
L
A
L
G
I
P
A
D
I
Y
L
I
D
E
P
S
A
Y
L
D
S
E
Q
----
R
I
I
C
S
K
V
----
I
----
R
R
F
I
L
H
N
K
K
---
T
----
A
F
I
V
E
H
D
F
I
M
-
A
T
Y
L
A
D
K
V
-
I
V
F
----
E
G
I
P
S
K
N
A
H
A
R
A
-
P
-
E
-
S
L
L
-
T
----------------------------------------------
8
PsiBlast_PDB
55.52
22%
-49
- C1 -
3J15
2
?
B:
[103-529]
----------------------------------------------------------------------------------------------------------------
G
M
-
V
V
G
I
V
G
P
N
G
T
G
K
T
T
A
V
K
I
-------
L
A
G
-------
Q
L
IPNLCEDN
D
S
W
D
--
N
--
V
I
R
A
F
R
--------------
G
--
N
E
L
-------
Q
N
Y
-
F
--------------
E
------------------------
R
L
K
N
G
E
I
R
P
V
V
K
P
Q
Y
V
D
---
L
L
P
K
A
V
K
G
------
K
V
R
E
L
----
L
K
K
V
D
E
V
G
K
F
E
E
V
V
K
E
L
E
L
E
N
V
L
D
R
E
L
H
Q
L
S
G
G
E
L
Q
R
V
A
I
A
A
A
L
L
R
K
A
H
F
Y
F
F
D
E
P
S
S
Y
L
D
I
R
-------
Q
R
L
K
V
A
R
V
I
R
R
L
A
N
----
E
----
G
K
---
A
V
L
V
V
E
H
D
----------
L
A
V
L
D
Y
L
S
D
V
I
H
V
V
Y
G
EP
G
V
Y
G
I
F
S
K
P
--
K
-------
G
T
R
N
G
I
N
E
F
L
Q
G
Y
L
K
D
E
N
V
R
F
R
P
Y
E
I
R
F
T
K
L
S
E
R
V
D
V
E
R
E
T
L
V
E
--------
Y
P
R
L
V
K
D
Y
G
S
F
K
L
E
V
E
P
G
--------------------------
E
I
R
K
G
E
V
-----
I
G
I
V
G
P
N
G
I
G
K
T
T
F
V
K
-
M
L
A
G
V
E
E
P
T
E
G
K
V
E
W
D
L
-
T
V
--
A
Y
K
P
Q
---
Y
I
K
A
E
-
Y
E
G
T
V
Y
------------------------------------------------------------------
E
L
L
S
K
I
----
D
------------------------------------
S
S
K
-----
L
N
-------
S
N
F
Y
K
T
E
L
L
K
P
L
G
I
I
D
L
-
Y
D
R
N
V
E
D
L
S
G
G
E
L
Q
R
V
A
I
A
A
T
L
L
R
D
A
D
I
Y
L
L
D
E
P
S
A
Y
L
D
V
E
Q
----
R
L
A
V
S
R
A
I
R
H
L
M
----
E
K
N
----
E
K
---
T
----
A
L
V
V
E
H
D
V
L
M
-
I
D
Y
V
S
D
R
L
-
I
--------------------------------------------------------------------------
9
PsiBlast_PDB
55.03
23%
-66
- C1 -
3OZX
5
?
A:
[29-457]
---------------------------------------------------------------------------------------------------------------------
G
V
L
G
K
N
G
V
G
K
T
T
V
L
K
I
-------
L
A
G
-------
E
I
--------
I
P
N
F
--
G
DP
N
S
K
V
G
K
--------------
D
--
E
V
L
--
K
R
F
R
G
K
E
I
-
Y
--------------
N
-
Y
--
F
K
-
E
L
Y
S
N
--
E
L
K
I
V
H
K
I
Q
Y
V
---
E
Y
A
S
K
F
L
K
G
T
V
N
E
I
-----------------
L
T
K
I
----
D
E
R
G
K
K
D
E
V
K
E
L
L
N
----
M
T
N
L
W
N
K
D
A
N
I
L
S
G
G
G
L
Q
R
L
L
V
A
A
S
L
L
R
E
A
D
V
Y
I
F
D
Q
P
S
S
Y
L
D
V
R
E
R
M
N
---
M
---
A
K
A
I
R
E
L
L
K
N
----------
K
---
Y
V
I
V
V
D
H
D
L
I
V
L
D
----
Y
L
T
D
L
----
I
H
I
I
Y
-----
G
E
S
S
V
Y
G
R
V
--
S
K
S
Y
A
A
R
V
G
------------
I
N
N
F
L
K
G
Y
L
P
A
E
N
M
K
I
R
P
D
E
I
K
F
M
L
K
---------------------------------
L
K
T
K
M
K
W
T
K
I
I
-----
K
K
L
G
D
F
Q
L
V
V
D
N
G
E
A
K
EG
E
I
I
G
I
L
G
P
N
G
I
G
K
T
T
F
A
R
-
I
L
V
G
E
I
T
A
D
E
G
S
----
V
-
T
P
E
K
Q
I
L
S
Y
K
P
Q
R
I
F
P
N
-
Y
D
G
T
V
Q
------------------------------------------------------------------
Q
Y
L
E
N
A
----
S
------------------------------------
K
D
A
-----
L
S
TSS
W
F
F
E
E
V
T
K
R
L
N
L
H
R
L
L
E
S
N
-------
V
N
D
L
S
G
G
E
L
Q
K
L
Y
I
A
A
T
L
A
K
E
A
D
L
Y
V
L
D
Q
P
S
S
Y
L
D
V
E
E
R
Y
I
V
A
K
A
I
K
R
V
----
T
----
R
E
R
----
K
A
---
V
----
T
F
I
I
D
H
D
L
S
I
-
H
D
Y
I
A
D
R
I
-
I
--------------------------------------------------------------------------
40
HHSearch
52.07
25%
-115
- C1 -
3D31
-
?
A:
[1-215]
---------------------------------------------------------------
M
I
E
I
E
S
L
S
R
K
W
K
-
N
---------
F
-
S
L
D
N
L
S
L
K
V
-------------
E
S
G
E
-
Y
F
V
I
L
G
P
T
G
A
G
K
T
L
F
L
E
L
-------
I
A
G
-------
F
H
--------
V
P
D
S
--
G
--
R
I
L
L
D
G
KDVTDLSPE-----
K
--
H
D
I
--
A
F
V
Y
-
Q
N
Y
-
S
--------------
L
-
F
--
P
H
-
M
N
V
K
K
--
N
L
E
F
G
M
R
M
K
K
---------------------------------------------
I
K
D
P
K
R
V
L
D
T
A
R
D
L
K
I
E
-
H
L
L
D
R
N
P
L
T
L
S
G
G
E
Q
Q
R
V
A
L
A
R
A
L
V
T
N
P
K
I
L
L
L
D
E
P
L
S
A
L
D
P
R
-------
T
---
Q
E
N
A
R
E
M
L
S
V
----
L
H
K
KN
K
L
---
T
V
L
H
I
T
H
D
Q
T
E
A
R
I
M
A
D
R
I
A
V
V
M
D
G
K
L
I
Q
V
------
G
K
P
E
E
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
51.72
24%
-109
- C1 -
3TUI
1
METN_ECOLI
C:
[24-252]
---------------------------------------------------------------
M
I
K
L
S
N
I
T
K
V
F
H
-
Q
GTRT---
I
-
Q
-
A
L
N
N
V
S
L
H
V
-------------
P
A
G
Q
-
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
-------
V
N
L
-------
L
E
--------
R
P
T
E
--
G
--
S
V
L
V
D
G
QELTTLSESELTKA
R
--
R
Q
I
--
G
M
I
F
-
Q
H
F
-
N
--------------
L
-
L
--
S
S
-
R
T
V
F
G
--
N
V
A
L
P
L
E
L
D
N
T
------------------------------------------
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
-
D
K
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
-------
T
---
T
R
S
I
L
E
L
L
K
D
----
I
NRRL
G
L
---
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
------
D
T
V
S
E
V
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
50.44
22%
-109
- C1 -
3RLF
3
MALK_ECOLI
A:
[3-221]
---------------------------------------------------------------
S
V
Q
L
Q
N
V
T
K
A
W
G
-
E
-------
V
-
V
-
V
S
K
D
I
N
L
D
I
-------------
H
E
G
E
-
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
-------
I
A
G
-------
L
E
--------
T
I
T
S
--
G
--
D
L
F
I
G
E
KRMNDTPPA-----
E
--
R
G
V
--
G
M
V
F
-
Q
S
Y
-
A
--------------
L
-
Y
--
P
H
-
L
S
V
A
E
--
N
M
S
F
G
L
K
L
A
G
A
------------------------------------------
K
K
E
V
I
N
Q
R
V
N
Q
V
A
E
V
L
Q
L
A
-
H
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
-------
L
---
R
V
Q
M
R
I
E
I
S
R
----
L
H
K
R
L
G
R
---
T
M
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
K
I
V
V
L
D
A
G
R
V
A
Q
V
------
G
K
P
L
E
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
50.05
24%
-112
- C1 -
1Z47
1
?
A:
[15-234]
----------------------------------------------------------------
I
E
F
V
G
V
E
K
I
Y
P
G
G
-------
A
-
R
-
S
V
R
G
V
S
F
Q
I
-------------
R
E
G
E
-
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
-------
I
A
G
-------
L
E
--------
R
P
T
K
--
G
--
D
V
W
I
G
G
KRVTDLPPQ-----
K
--
R
N
V
--
G
L
V
F
-
Q
N
Y
-
A
--------------
L
-
F
--
Q
H
-
M
T
V
Y
D
--
N
V
S
F
G
L
R
E
K
R
V
------------------------------------------
P
K
D
E
M
D
A
R
V
R
E
L
L
R
F
M
R
L
E
-
S
Y
A
N
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
-------
I
---
R
R
E
L
R
T
F
V
R
Q
V
H
D
E
M
----
G
V
---
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
Q
F
------
G
T
P
E
E
V
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
47.99
26%
-100
- C1 -
3FVQ
3
FBPC_NEIG1
A:
[4-232]
---------------------------------------------------------------
A
L
H
I
G
H
L
S
K
S
F
Q
-
N
-------
T
-
P
-
V
L
N
D
I
S
L
S
L
-------------
D
P
G
E
-
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
-------
L
A
G
-------
F
E
--------
Q
P
D
S
--
G
--
E
I
S
L
S
G
KTIFSKN
T
N
L
P
VR-
E
--
R
R
L
--
G
Y
L
V
-
Q
E
G
-
V
--------------
L
-
F
--
P
H
-
L
T
V
Y
R
--
N
I
A
Y
G
L
G
N
G
K
G
------------------------------------------
R
T
A
Q
E
R
Q
R
I
E
A
M
L
E
L
T
G
I
S
-
E
L
A
G
R
Y
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
-------
L
---
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
N
----
G
K
---
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
Q
T
------
A
S
P
H
E
L
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
47.33
21%
-115
- C1 -
1V43
-
?
A:
[12-231]
---------------------------------------------------------------
E
V
K
L
E
N
L
T
K
R
F
G
-
N
-------
F
-
T
-
A
V
N
K
L
N
L
T
I
-------------
K
D
G
E
-
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
-------
I
A
G
-------
L
E
--------
E
P
T
E
--
G
--
R
I
Y
F
G
D
RDVTYLPPK-----
D
--
R
N
I
--
S
M
V
F
-
Q
------------------------
H
-
M
T
V
Y
E
--
N
I
A
F
P
L
--
K
K
F
------------------------------------------
P
K
D
E
I
D
K
R
V
R
W
A
A
E
L
L
Q
I
E
-
E
L
L
N
R
Y
P
A
Q
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
E
P
D
V
L
L
M
D
E
P
L
S
N
L
D
A
K
-------
L
---
R
V
A
M
R
A
E
I
K
K
----
L
Q
Q
K
L
K
V
---
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
R
G
Q
L
L
Q
I
G
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
47.11
25%
-79
- C1 -
2IWH
8
EF3A_YEAST
A:
[443-728]
-----------------------------------------------------------------------
L
A
Y
G
-
A
-------
K
-
I
-
L
L
N
K
T
Q
L
R
L
-------------
K
R
A
R
-
R
Y
G
I
C
G
P
N
G
C
G
K
S
T
L
M
R
A
-------
I
A
---------------------
N
--
G
--
Q
V
--------------------------------
D
G
-
F
--------------
P
-
T
--
Q
E
-
E
C
--
R
--
T
V
Y
V
E
H
D
-----
I
D
G
T
H
S
D
T
S
V
L
D
F
V
F
E
S
G
V
G
T
K
E
----------------------
A
I
K
D
K
L
I
---
E
F
G
F
T
D
E
M
I
A
M
P
I
S
A
L
S
G
G
W
K
M
K
L
A
L
A
R
A
V
L
R
N
A
D
I
L
L
L
D
E
P
T
N
H
L
D
T
V
-------
N
---
V
A
W
L
V
N
Y
L
N
T
----
C
----
G
I
---
T
S
I
T
I
S
H
D
S
V
F
L
D
N
V
C
E
Y
I
I
N
Y
E
G
L
K
L
R
K
Y
K
-----
G
N
F
T
E
F
V
K
K
--
C
P
A
A
K
A
Y
E
E
L
S
N
T
D
L
E
F
K
F
P
E
P
G
Y
L
------
E
G
V
K
T
K
Q
-----
K
A
I
V
K
V
T
N
M
E
F
Q
-----
Y
P
-----
G
T
S
-
K
P
Q
------------------------
I
T
D
I
N
F
Q
C
S
L
S
S
R
-----
I
A
V
I
G
P
N
G
A
G
K
S
T
L
I
N
-
V
L
T
G
E
L
L
P
T
S
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------