@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1466: (2016-03-25 )
VKLAKKWRDWYIESGKKYLFPLLLVCFAVIAYFLVCQMTKPESYNVKLFQVAEKTIRSPQTVEDTEKTKEERTKASDAVEDVYVYNRETGQNRVALIQSLFAYVNEVNAEAQEKDTKNKEKAKKENKPAPAPTSTEDKLKNLKDKLSSNVSEKITSNISDEVFTTLIEAKSKDFNVMEDVVTTEVEKSMENKIRDENLNSVKIRARDDIELSAIPAYYKNVSKALVSYAIVPNEVYDEEQTDARRKEAAQSVVPVKILQGQVIVQEGQIVDRETYRQLKMLHLLDQKMPVKQYAGFAIFIIALAAILFLYTKKQTQPKAKKMQTMLIFSSVYLVSLFMLFIILFLETQNIANIAFLFPAAFAPMILKILLNEKYAFLSVIFIAVTSLLTFQNDATSGITIFILLSGATSVVMLRDYSRRSAIMLSGFMVGLINMIYVLLLLLINNSTLLQVSTLMALGYAFLGGFGAFILGVGVIPLFETIFGLLTTSRLVELANPNHPLLKKILMKAPGTYHHSMMVANLAEACADKIGANSLLVRVGCFYHDIGKTLRPPYFVENQLQGINPHDRLTPEQSRDIILSHTKDGAEILKENHMPQPIIDIALQHHGTTLLKYFYFKAKETNPDVKEADYRYSGPKPQTKEIAIINISDSVEAAVRSSTEPTMAKITEIIDGIIKDRFLDGQFTECDITIQEIKIIRDTLIATLNGIYHQRIQYPDDKD
Atome Classification :
(20 SA)
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------.........10........------20........30.....--...40-........50........60........70........80........90........100.......110......--.120.......130.......140.......150....--...160.......170...-....180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.....-..290.......300.----......310.......320-----........330.......340.......350......------.360.......370....-...380.......390....-...400....-----...410.......420.......430.......440----.........-450....--...460.......470...-----------....480.......490-------------......-..500.......510....--...520.......530----.-..----......540.......550.......560.---...-..--.--570......--.580..------------.....590--------.-..-.-------.----....600.......610...--....620.......630.......640.......650.....--..660...-....670...---------....680.......690.......700.......710......-------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------V
K
L
A
K
K
W
R
D
W
Y
I
ESG
K
K
Y
L
------
F
P
L
L
L
V
C
F
A
V
I
A
Y
F
L
V
C
--QMTKP-ESY
N
V
K
L
F
Q
V
A
E
K
TIRSPQTV
E
D
T
E
K
T
K
E
E
RTKASDAV
E
D
V
Y
V
Y
NRETG
Q
N
R
V
A
L
I
Q
S
L
F
A
Y
V
N
EVNAEAQEKDTK
N
--
K
E
K
AKKENKPAPAPT
S
T
E
D
K
L
K
N
L
K
D
K
L
S
S
N
V
S
E
K
I
T
S--NI
S
D
E
V
F
T
T
L
I
E
AKSK
D
F
N
-
V
M
E
D
V
V
T
T
E
V
E
K
S
M
E
N
K
IRDENL
N
S
V
K
I
R
ARDDIEL
S
A
I
P
A
Y
Y
K
N
V
S
K
A
L
V
S
YAIVPNEVYDE
E
Q
T
D
A
R
R
K
E
A
A
QSVV
P
V
K
I
LQ
G
Q
V
I
V
QEGQIV
D
R
E
T
Y
R
Q
L
K
M
L
H
L
L
DQK-M
P
V
K
Q
YAG
F
A
I
F
I
I
A
L
----
A
A
I
L
F
L
YTKKQTQ
P
K
A
K
K
------
M
Q
T
M
L
I
F
S
S
V
Y
L
V
S
L
F
M
L
F
I
I
L
F
LETQNI
A
N
I
A
F
L
F
P
------
A
A
F
A
P
M
I
L
K
I
L
LNE
K
Y
A
F
-
L
S
V
I
F
I
A
V
T
S
L
L
T
FQNDATS-
G
I
T
I
F
I
L
LSG-----A
T
S
V
V
M
L
RDYSRR
S
A
I
M
L
S
G
F
M
V
G
L
I
N
M
I
Y
V
L
L
L
------
L
L
INNS
T
L
L
-
Q
V
S
T
L
M
A
--
L
G
Y
A
F
L
G
G
F
G
A
F
I
L
G
V
G
V
I
-----------
P
L
F
E
T
I
F
G
L
L
T
T
S
R
L
V
--------------
E
LANPN-
H
P
L
L
K
K
I
L
M
KAPGT
Y
H
H
S
M
--
M
V
A
N
L
A
E
A
C
A
D
KIG------A-
N
S
----
L
L
V
R
V
G
C
F
Y
H
D
I
G
K
TLRPP
Y
F
V
E
N
QLQGIN---PHD-RL--T--
P
E
QSR
D
I
I
L
--SHTK
D
G
------------
A
E
I
L
K
E----------N-HM-P-------Q----
P
I
I
D
I
A
L
Q
HH
G
T
T
L
L
K
Y
F
Y
F
--
K
AKETNPDVKEADYRYSGPKPQT
K
E
I
A
I
I
NIS
D
S
V
E
A
A
V
RSS--TE
P
T
M
A
K
I
-
T
E
I
I
D
G
I
I
K
D
---------RFLDGQFTEC
D
I
T
I
Q
E
I
K
I
I
R
D
T
L
I
A
T
L
N
G
I
Y
H
Q
RIQYPDDKD-------
10
PsiBlast_CBE
98.68
100%
-73
- C3 -
4S1B
4
?
D:
[1-214]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
N
P
N
-
H
P
L
L
K
K
I
L
M
K
A
P
G
T
Y
H
H
S
M
--
M
V
A
N
L
A
E
A
C
A
D
K
I
G
------
A
-
N
S
----
L
L
V
R
V
G
C
F
Y
H
D
I
G
K
T
L
R
P
P
Y
F
V
E
N
Q
L
Q
G
I
N
---
P
H
D
-
R
L
--
T
--
P
E
Q
S
R
D
I
I
L
--
S
H
T
K
D
G
------------
A
E
I
L
K
E
----------
N
-
H
M
-
P
-------
Q
----
P
I
I
D
I
A
L
Q
H
H
G
T
T
L
L
K
Y
F
Y
F
--
K
A
K
E
T
N
P
D
V
K
E
A
D
Y
R
Y
S
G
P
K
P
Q
T
K
E
I
A
I
I
N
I
S
D
S
V
E
A
A
V
R
S
S
--
T
E
P
T
M
A
K
I
-
T
E
I
I
D
G
I
I
K
D
---------
R
F
L
D
G
Q
F
T
E
C
D
I
T
I
Q
E
I
K
I
I
R
D
T
L
I
A
T
L
N
G
I
Y
------------------
1
PsiBlast_PDB
95.83
100%
-72
- C3 -
4S1B
4
?
A:
[5-220]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
P
L
L
K
K
I
L
M
K
A
P
G
T
Y
H
H
S
M
--
M
V
A
N
L
A
E
A
C
A
D
K
I
G
------
A
-
N
S
----
L
L
V
R
V
G
C
F
Y
H
D
I
G
K
T
L
R
P
P
Y
F
V
E
N
Q
---
I
N
---
P
H
D
-
R
L
--
T
--
P
E
Q
S
R
D
I
I
L
--
S
H
T
K
D
G
------------
A
E
I
L
K
E
----------
N
-
H
M
-
P
-------
Q
----
P
I
I
D
I
A
L
Q
H
H
G
T
T
L
L
K
Y
F
Y
F
--
K
A
K
E
T
N
P
D
V
K
E
A
D
Y
R
Y
S
G
P
K
P
Q
T
K
E
I
A
I
I
N
I
S
D
S
V
E
A
A
V
R
S
S
--
T
E
P
T
M
A
K
I
-
T
E
I
I
D
G
I
I
K
D
---------
R
F
L
D
G
Q
F
T
E
C
D
I
T
I
Q
E
I
K
I
I
R
D
T
L
I
A
T
L
N
G
I
Y
H
Q
R
I
Q
Y
------------
37
Fugue
95.57
99%
-72
- C3 -
4S1B
4
?
A:
[5-220]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
P
L
L
K
K
I
L
M
K
A
P
G
T
Y
H
H
S
M
--
M
V
A
N
L
A
E
A
C
A
D
K
I
G
------
A
-
N
S
----
L
L
V
R
V
G
C
F
Y
H
D
I
G
K
T
L
R
P
P
Y
F
V
E
N
Q
I
---
N
---
P
H
D
-
R
L
--
T
--
P
E
Q
S
R
D
I
I
L
--
S
H
T
K
D
G
------------
A
E
I
L
K
E
----------
N
-
H
M
-
P
-------
Q
----
P
I
I
D
I
A
L
Q
H
H
G
T
T
L
L
K
Y
F
Y
F
--
K
A
K
E
T
N
P
D
V
K
E
A
D
Y
R
Y
S
G
P
K
P
Q
T
K
E
I
A
I
I
N
I
S
D
S
V
E
A
A
V
R
S
S
--
T
E
P
T
M
A
K
I
-
T
E
I
I
D
G
I
I
K
D
---------
R
F
L
D
G
Q
F
T
E
C
D
I
T
I
Q
E
I
K
I
I
R
D
T
L
I
A
T
L
N
G
I
Y
H
Q
R
I
Q
Y
------------
9
PsiBlast_CBE
95.43
100%
-72
- C3 -
4S1C
2
?
A:
[4-215]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-
H
P
L
L
K
K
I
L
M
K
A
P
G
T
Y
H
H
S
M
--
M
V
A
N
L
A
E
A
C
A
D
K
I
G
------
A
-
N
S
----
L
L
V
R
V
G
C
F
Y
H
D
I
G
K
T
L
R
P
P
Y
F
V
E
N
Q
L
Q
G
I
N
---
P
H
D
-
R
L
--
T
--
P
E
Q
S
R
D
I
I
L
--
S
H
T
K
D
G
------------
A
E
I
L
K
E
----------
N
-
H
M
-
P
-------
Q
----
P
I
I
D
I
A
L
Q
H
H
G
T
T
L
L
K
Y
F
Y
F
--
K
A
K
E
----
V
K
E
A
D
Y
R
Y
S
G
P
K
P
Q
T
K
E
I
A
I
I
N
I
S
D
S
V
E
A
A
V
R
S
S
--
T
E
P
T
M
A
K
I
-
T
E
I
I
D
G
I
I
K
D
---------
R
F
L
D
G
Q
F
T
E
C
D
I
T
I
Q
E
I
K
I
I
R
D
T
L
I
A
T
L
N
G
I
Y
H
-----------------
2
PsiBlast_PDB
94.84
100%
-73
- C3 -
4S1C
2
?
D:
[4-215]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
-
H
P
L
L
K
K
I
L
M
K
A
P
G
T
Y
H
H
S
M
--
M
V
A
N
L
A
E
A
C
A
D
K
I
G
------
A
-
N
S
----
L
L
V
R
V
G
C
F
Y
H
D
I
G
K
T
L
R
P
P
Y
F
V
E
N
Q
L
Q
G
I
N
---
P
H
D
-
R
L
--
T
--
P
E
Q
S
R
D
I
I
L
--
S
H
T
K
D
G
------------
A
E
I
L
K
E
----------
N
-
H
M
-
P
-------
Q
----
P
I
I
D
I
A
L
Q
H
H
G
T
T
L
L
K
Y
F
Y
F
--
K
A
K
----
D
V
K
E
A
D
Y
R
Y
S
G
P
K
P
Q
T
K
E
I
A
I
I
N
I
S
D
S
V
E
A
A
V
R
S
S
--
T
E
P
T
M
A
K
I
-
T
E
I
I
D
G
I
I
K
D
---------
R
F
L
D
G
Q
F
T
E
C
D
I
T
I
Q
E
I
K
I
I
R
D
T
L
I
A
T
L
N
G
I
Y
H
-----------------
40
Fugue
68.01
14%
-73
- C3 -
3TM8
5
?
A:
[20-328]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
D
Y
V
S
-
I
R
V
S
T
L
R
G
D
Q
K
I
D
F
N
A
Y
V
K
I
-
N
D
K
M
I
L
Y
L
R
R
G
D
S
F
E
G
E
R
L
K
R
L
K
D
K
K
L
R
K
M
Y
I
L
T
D
E
E
N
S
Y
R
T
Y
L
Q
K
N
I
E
------
T
A
Y
D
D
T
T
G
K
D
I
Q
T
R
A
D
I
--
I
Q
G
S
Q
Q
N
N
A
E
E
V
F
E
N
P
E
N
V
-----------
E
S
Y
N
Y
C
K
D
A
A
G
K
Y
V
N
F
--------------
I
M
S
N
A
Q
A
L
S
A
V
M
N
I
E
N
T
D
K
T
I
S
H
H
G
V
--
T
V
S
T
L
S
I
A
L
A
Q
K
L
G
ITD
P
--
K
-
K
T
----
Q
L
L
T
L
G
A
L
L
H
D
Y
G
H
H
H
S
P
L
-------
N
L
N
Q
---
P
L
D
-
S
M
--
S
---
P
E
D
L
A
L
W
K
--
K
H
P
I
E
G
------------
A
Q
K
V
Q
D
K---------
K
-
H
F
-
D
-------
Q
----
T
V
I
N
I
I
G
Q
H
E
---------------
E
T
I
N
G
T
G
P
K
G
L
R
E
K
D
M
D
P
L
A
V
L
V
S
S
A
N
A
M
D
R
L
I
T
F
E
G
V
P
--
K
A
E
A
A
K
K
L
-
M
I
D
H
V
G
K
H
P
L
---------
Q
H
I
Q
H
L
N
D
I
L
K
G
L
-------------------------------------
14
HHSearch
53.80
23%
-28
- C3 -
3TM8
5
?
A:
[159-327]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
E
N
T
D
K
T
I
S
H
H
G
V
--
T
V
S
T
L
S
I
A
L
A
Q
K
L
G
------
I
-
T
D
P
K
K
T
Q
L
L
T
L
G
A
L
L
H
D
Y
G
H
H
H
S
P
L
N
-------
L
N
Q
---
P
L
D
-
S
M
--
S
--
P
E
D
L
-
A
L
W
K
--
K
H
P
I
E
G
------------
A
Q
K
V
Q
D
----------
K
K
H
F
-
D
-------
Q
----
T
V
I
N
I
I
G
Q
H
E
E
T
I
N
G
-
T
G
-
P
--
K
G
L
R
E
-
K
D
M
-------------
D
P
L
A
V
L
V
S
S
A
N
A
M
D
R
L
I
T
F
E
--
G
V
P
----
K
-
A
E
A
A
K
K
L
M
I
D
-----------
H
V
G
K
H
P
L
---------
Q
H
I
Q
H
L
N
D
I
L
K
G
--------------------
43
Fugue
51.19
14%
-42
- C1 -
3W3W
1
IMB3_YEAST
A:
[3-1077]
ALP
E
E
V
N
R
T
L
L
Q
I
V
Q
A
FASD
N
Q
I
R
S
V
A
E
K
A
L
S
EEWITENN
I
E
Y
L
L
T
F
L
A
E
Q
A
A
FSQD
T
T
V
A
A
L
S
A
V
L
F
R
K
L
A
L
K
A
PITHIR
K
E
V
L
A
Q
I
R
S
S
L
L
K
G
F
L
SERA
D
S
I
R
H
K
L
S
D
A
I
A
E
C
VQDDLPAW
P
E
L
L
Q
A
L
I
E
S
L
K
SGN
P
N
F
R
E
S
S
F
R
I
L
T
T
V
P
Y
L
I
T
A
VD
I
N
S
I
L
P
I
F
Q
S
G
F
T
DAS
D
N
V
K
I
A
A
V
T
A
F
V
G
Y
F
K
Q
LPKSEWSKLGIL
L
P
S
L
L
N
S
L
P
R
F
L
D
D
GK
D
D
A
L
A
S
V
F
E
S
L
I
E
L
V
E
L
A
P
K
L
F
K
D
M
F
D
Q
I
I
Q
F
T
D
M
V
I
K
NKDLE
P
P
A
R
T
T
A
L
E
L
L
T
V
F
S
E
N
A
P
Q
M
C
K
S
N
Q
N
Y
G
Q
T
L
V
M
V
T
L
I
M
M
-
T
E
V
S
I
D
D
D
D
A
A
E
W
I
E
S
D
D
T
D
D
E
E
E
V
T
Y
D
H
A
R
Q
A
L
D
R
V
A
L
K
L
G
G
E
Y
L
A
A
P
L
F
Q
Y
L
Q
Q
M
I
T
S
T
E
W
R
E
R
F
A
A
M
M
A
L
S
S
A
A
E
G
C
A
D
V
L
I
G
E
I
P
K
I
L
D
M
V
I
P
L
I
N
D
PH
P
R
V
Q
Y
G
C
C
N
V
L
G
Q
I
S
T
D
F
S
P
F
I
Q
R
T
A
H
D
R
I
L
P
A
L
I
S
K
L
T
S
E
C
T
S
R
V
Q
T
H
A
A
A
A
L
V
N
F
S
E
F
A
S
-
K
D
I
L
E
P
Y
L
D
S
L
L
T
N
L
L
V
L
L
Q
S
N
K
L
Y
V
Q
E
Q
A
L
T
T
I
A
F
I
A
E
A
A
K
N
K
F
I
K
Y
Y
D
T
L
M
P
L
L
L
N
V
L
K
V
N
S
V
L
K
G
K
C
M
E
C
A
T
L
I
G
F
A
V
G
K
E
K
F
H
E
H
S
Q
E
L
I
S
I
L
V
A
L
Q
N
S
D
A
L
R
S
Y
L
E
Q
S
W
S
R
I
C
R
I
L
G
D
D
F
V
P
L
L
P
I
V
I
P
P
L
L
I
T
A
K
A
T
Q
D
V
G
L
I
E
E
EEAANF
Q
Q
Y
P
D
W
D
V
V
Q
V
Q
G
K
H
I
A
I
H
T
S
V
L
D
D
K
V
S
A
M
E
L
L
Q
S
Y
A
T
L
L
R
G
Q
F
A
V
Y
V
K
E
-----
V
M
E
E
I
A
L
P
S
L
D
F
Y
L
H
D
G
V
R
A
A
G
A
T
L
I
P
I
L
L
S
C
L
L
A
AE
E
L
V
L
L
W
H
K
A
S
S
K
-
L
I
G
G
L
M
S
EP
M
P
E
I
T
Q
V
Y
H
N
S
L
V
N
G
I
K
V
M
GDNCLS
E
D
Q
L
A
A
F
T
K
G
V
S
A
N
L
T
D
T
Y
E
R
M
Q
DRDEYNED
F
T
D
E
D
L
L
D
E
I
-
N
K
S
I
A
A
V
L
K
T
T
N
G
H
Y
L
K
N
L
E
N
I
W
P
M
I
N
T
F
L
L
E
P
I
L
------
V
-
I
F
----
A
L
V
V
I
G
D
L
I
Q
Y
E
Q
T
A
S
M
K
N
A
F
I
P
K
V
T
E
C
L
I
---
S
P
D
-
A
R
--
I
--
R
Q
A
A
S
Y
I
I
G
--
V
C
A
Q
Y
A
PSTYADVCIPT
L
D
T
L
V
Q
I
----------
V
-
D
G
-
S
-------
K
----
L
E
E
N
R
S
S
T
E
N
A
S
A
A
I
A
K
I
L
Y
--
A
Y
N
S
N
I
P
D
T
Y
T
A
N
W
F
K
T
L
P
T
I
T
D
K
E
A
A
S
F
N
Y
Q
F
L
S
Q
V
C
A
Q
S
N
---------
I
-
S
A
V
V
D
S
V
I
Q
A
---------
L
N
-----
E
R
S
L
T
V
I
S
S
V
K
K
L
L
G
F
L
P
S
S
D
A
M
A
I
F
N
R
--
Y
P
A
D
I
M
E
K
V
H
K
W
F
17
HHSearch
50.86
17%
-24
- C3 -
2O08
7
?
A:
[16-166]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
E
H
R
Y
Q
H
T
I
--
G
V
M
E
T
A
I
D
L
A
K
L
Y
G
------
A
-
D
Q
----
Q
K
A
E
L
A
A
I
F
H
D
Y
A
K
F
R
D
K
N
E
M
R
T
L
I
R
-------
E
K
L
-
S
Q
--
Q
--
D
I
L
F
Y
G
D
E
L
--
L
H
A
P
C
G
------------
A
Y
Y
V
R
E
E---------
V
-
G
I
-
E
-------
D
E
---
D
V
L
Q
A
I
R
F
H
T
T
G
R
---------------
P
-------------
N
M
S
L
L
E
K
I
I
F
L
A
D
Y
I
E
P
N
R
-----
Q
F
P
--------
G
V
E
K
V
R
T
Q
-----------
A
K
T
D
L
N
G
---------
A
I
I
S
S
L
V
N
T
I
T
F
L
L
------------------
19
HHSearch
50.28
19%
-20
- C3 -
3CCG
3
?
A:
[16-167]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
K
R
Y
K
H
S
L
--
G
V
M
D
T
A
V
R
L
A
G
I
Y
N
------
E
-
D
T
----
E
K
A
R
I
A
G
L
V
H
D
C
A
K
K
L
P
G
E
K
I
I
E
I
----
C
T
---
N
E
G
Y
E
L
--
G
--
D
E
D
I
R
N
S
Y
L
--
L
H
G
L
A
G
------------
R
I
L
A
K
K
----------
V
I
G
I
D
D
-------
E
----
D
V
L
N
A
I
E
F
H
T
T
G
------
R
P
----------------------
N
M
S
L
L
E
K
I
I
Y
I
A
D
Y
I
E
P
G
R
-----
E
F
K
---
G
-----
V
D
E
L
R
K
A
-----------
A
D
E
D
L
N
K
---------
A
L
L
M
S
F
D
N
T
I
K
F
V
-------------------
16
HHSearch
49.31
17%
5
- C3 -
2OGI
5
?
A:
[24-142]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
K
R
F
N
H
V
L
--
G
V
E
R
A
A
I
E
L
A
E
R
Y
G
------
Y
-
D
K
----
E
K
A
G
L
A
A
L
L
H
D
Y
A
K
E
L
S
D
D
E
F
L
R
L
I
D
-------
K
-
Y
-
Q
P
D
P
D
--
L
K
K
W
-
G
N
N
I
--
W
H
G
L
V
G
------------
I
Y
K
I
Q
E
D
---------
L
-
A
I
K
D
-------
Q
----
D
I
L
A
A
I
A
K
H
T
V
G
------
S
---------
A
-------------
Q
M
S
T
L
D
K
I
V
Y
V
A
D
Y
I
E
H
N
R
-----------------------------------------------------------------------------------
28
HHSearch
48.06
9%
-34
- C3 -
1U6Z
7
PPX_ECOLI
A:
[318-497]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
A
S
S
L
A
N
Q
Y
H
I
D
S
E
Q
A
R
--
R
V
L
D
T
T
M
Q
M
Y
E
Q
W
R
E
Q
Q
PKL
A
-
H
P
Q
L
E
-
A
L
L
R
W
A
A
M
L
H
E
V
G
L
N
I
N
H
S
------------------------------------
G
L
H
R
H
S
------------
A
Y
I
L
Q
N
----------
S
-
D
L
-
P
GFN
Q
E
Q
Q
L
----
M
M
A
T
L
V
R
Y
H
R
K
A
I
K
L
-
D
D
L
P
R
F
T
L
F
K
K
-
K
Q
-------------
F
L
P
L
I
Q
L
L
R
L
G
V
L
L
N
N
Q
R
Q
A
T
T
T
P
P
T
L
T
L
I
T
D
D
S
H
W
T
L
R
-------------
F
P
H
D
W
F
S
Q
N
A
L
V
L
L
D
L
E
K
E
Q
E
Y
W
E
G
V
A
----------------------
20
HHSearch
47.29
20%
-5
- C3 -
3HC1
4
?
A:
[116-290]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
T
L
W
A
H
S
L
--
G
V
A
R
I
A
K
L
I
A
E
R
T
G
------
F
L
N
P
----
V
N
V
Y
V
A
G
L
L
H
D
V
G
E
V
F
I
N
F
F
R
G
K
E
F
S
Q
V
V
T
L
V
-
D
E
E
-
K
I
--
T
F
G
Q
A
E
E
R
L
F
G
T
--
S
H
C
E
V
G
------------
F
A
L
A
K
R
----------
W
-
S
L
-
N
-------
E
----
F
I
C
D
T
I
L
Y
H
H
D
I
----
E
A
V
P
--
Y
-------------------
K
Q
A
A
I
V
A
M
V
A
F
A
D
E
Y
C
T
L
R
R
L
G
--
F
--
E
G
H
K
P
-
V
D
S
V
R
T
L
L
E
N
H
P
S
W
G
V
I
R
R
S
L
G
G
S
D
F
D
E
---------
K
L
I
V
A
E
L
D
S
-----------------------
18
HHSearch
46.82
10%
-24
- C3 -
3M1T
1
?
A:
[102-263]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
A
D
F
W
G
N
T
F
--
E
V
A
I
I
C
Q
E
L
A
K
R
L
G
------
T
-
L
P
----
E
E
A
F
T
C
G
I
L
H
S
I
G
E
L
L
I
V
N
G
D
P
A
V
A
A
T
I
S
A
A
V
A
D
G
A
-
D
R
--
N
--
L
M
E
K
E
L
L
G
Y
--
D
N
A
E
I
G
------------
A
L
L
A
Q
S
----------
W
-
K
F
-
T
-------
P
----
H
L
V
K
G
I
Q
F
Q
N
H
P
K
S
A
-------------
E
-------------
P
Y
S
K
L
A
G
M
L
A
M
A
K
Q
I
A
A
D
W
D
K
I
--
P
D
D
---
E
R
-
T
S
W
L
A
Q
I
N
I
-----------
L
A
G
I
K
V
D
L
---------
G
G
L
A
E
K
L
A
K
M
----------------------
27
HHSearch
45.80
16%
-0
- C3 -
2DQB
1
?
A:
[73-204]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
R
T
R
L
T
H
T
L
--
E
V
A
Q
V
S
R
S
I
A
R
A
L
G
------
L
-
N
E
----
D
L
T
E
A
I
A
L
S
H
D
L
G
H
P
P
F
G
H
T
G
E
H
--------------
V
L
--
N
--
A
L
M
Q
D
H
G
G
F
--
E
H
N
A
Q
A
------------
L
R
I
L
T
H
LEVRYPGFRG
L
-
N
L
-
T
-------
Y
----
E
V
L
E
G
I
A
T
H
E
A
------------------------------
G
Q
G
T
L
E
A
Q
V
V
D
L
S
D
A
I
A
Y
A
A
H
D
---------------------------------------------------------------------------------
36
HHSearch
45.58
14%
-4
- C3 -
2QGS
1
?
A:
[23-129]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
G
H
D
I
A
H
V
E
--
R
V
Y
N
N
A
C
Y
I
A
K
R
E
N
I-----
T
-
D
T
----
L
V
I
E
L
S
S
L
L
H
D
T
V
D
S
K
L
T
----------------
D
E
----------------
I
--
L
A
Y
D
Q
L
------------
K
Q
F
L
S
T
----------
L
-
D
L
-
S
-------
S
E
I
S
Q
Q
V
L
Y
I
I
K
H
M
S
-----------------------------
H
V
-
K
L
S
I
D
G
E
I
V
R
D
A
D
R
L
D
A
I
G
-----------------------------------------------------------------------------------
5
PsiBlast_PDB
45.00
31%
15
- C3 -
3TMC
4
?
A:
[169-260]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
G
V
--
T
V
S
T
L
S
I
A
L
A
Q
K
L
G
ITD
P
--
K
-
K
T
----
Q
L
L
T
L
G
A
L
L
H
D
Y
G
H
H
H
S
P
L
N
L
--
N
Q
--------
P
L
D
-
S
M
--
S
--
P
E
---
D
L
A
L
W
K
K
H
P
I
E
G
------------
A
Q
K
V
Q
D
K---------
K
-
H
F
-
D
-------
Q
----
T
V
I
N
I
I
G
Q
H
E
E
T
------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
44.93
16%
-1
- C3 -
3DJB
1
?
A:
[22-140]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
G
H
D
W
Y
H
I
R
--
R
V
H
K
M
A
I
S
L
S
E
Q
E
G
------
G
-
N
R
----
F
I
I
E
M
A
A
L
L
H
D
V
A
D
--
L
N
E
S
-------------------------------
E
E
--
A
G
M
K
K
V
------------
S
D
W
L
E
E
----------
L
-
H
V
-
E
-------
E
E
E
S
K
H
V
L
H
I
I
A
N
M
S
-----------------------------------
I
E
G
K
L
V
Q
D
A
D
R
L
D
A
L
G
-----------------------------------------------------------------------------------
11
PsiBlast_CBE
44.89
31%
18
- C3 -
3TMC
4
?
B:
[169-260]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
G
V
--
T
V
S
T
L
S
I
A
L
A
Q
K
L
G
ITDP--
K
-
K
T
----
Q
L
L
T
L
G
A
L
L
H
D
Y
G
H
H
H
S
P
L
N
L
--
N
Q
--------
P
L
D
-
S
M
--
S
--
P
E
---
D
L
A
L
WK
K
H
P
I
E
G
------------
A
Q
K
V
Q
D
K---------
K
-
H
F
-
D
-------
Q
----
T
V
I
N
I
I
G
Q
H
E
E
T
------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_CBE
44.79
31%
15
- C3 -
3TM8
4
?
B:
[169-260]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
H
G
V
--
T
V
S
T
L
S
I
A
L
A
Q
K
L
G
ITD
P
--
K
-
K
T
----
Q
L
L
T
L
G
A
L
L
H
D
Y
G
H
H
H
S
P
L
N
L
--
N
Q
--------
P
L
D
-
S
M
--
S
--
P
E
---
D
L
A
L
W
K
K
H
P
I
E
G
------------
A
Q
K
V
Q
D
K---------
K
-
H
F
-
D
-------
Q
----
T
V
I
N
I
I
G
Q
H
E
E
T
------------------------------------------------------------------------------------------------------------------------------------