@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1849: (2016-03-29 )
MEIQGLTIAYKQKVAIDNVTLQIASGKLTGIVGPNGAGKSTLLKGMMGLIPREQGQVTLADKPLTYWRKKIAYVPQRSEVDLTFPITVFDMVLLGTYPALGLIKRPGKKEKQLALDALEQVEMTGFMKRQIGELSGGQLQRVFIARALAQHAEIFFLDEPFAGIDMTSEALIMRLLKKLRDNGKTIVVVHHDFHKVAAYFDDIILLNKKLVAHGPVEQTFTEEKIQFAYGDAPVAFAAGV
Atome Classification :
(29 SA)
----.........10-.----.----..-.....20........30........40........50......--------.--------.-60-----.---.-----..-.------------------.--.--..-------70--.-----......-..80...-.-....90-.........100.......110.--......120-....-..-.----.130.......140.......150----.........160.......170.......-180-.--..-..-...190.......200.-...-.-.-.210.......220.......230.......240---------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----MEIQ
G
L
T
I
A
Y
--
K
----
Q
----
K
V
-
A
ID
N
V
T
L
Q
I
AS
G
K
L
T
G
I
VGPNGA
G
K
S
T
L
L
K
G
M
M
G
LIPREQG
Q
V
--------
T
--------L-A------D---K-----
P
L
-
T
------------------
Y
--
W
--
R
K
-------
K
---
I
-----AYVPQR-SEV
D
L
T
F
-
P
-
I
T
V
F
D
--
M
V
L
LGT
Y
P
A
L
G
L
IKRPGK
K
E
K
Q
L
--
A
L
D
A
L
E
Q
V
--
E
M
T
G
-
F
M
-
K
----
R
Q
I
G
ELSG
G
Q
L
Q
R
V
F
I
A
R
A
L
A
Q------HA
E
I
F
F
LDEPFAGIDM
T
S
E
A
L
I
M
R
L
L
K
K
L
-R-D-N--G
K
-
T
I
-
V
V
V
HH
D
F
H
K
V
A
A
Y
F
D
D
I
-
I
L
L-N-K-KLVAHGPVEQTFTEE
K
I
Q
F
AYGDAP
V
A
FAAGV-----------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
89.14
33%
-131
- C1 -
4G1U
1
HMUV_YERPE
C:
[12-245]
----
L
E
A
S
H
L
H
Y
H
V
--
Q
----
Q
----
Q
A
-
L
I
N
D
V
S
L
H
I
A
S
G
E
M
V
A
I
I
G
P
N
G
A
G
K
S
T
L
L
R
L
L
T
G
Y
L
S
P
S
H
G
E
C
--------
H
--------
L
-
L
------
G
---
Q
-----
N
L
-
N
------------------
S
--
W
--
Q
P
-------
K
---
A
L
A
R
T
R
A
V
M
R
Q
Y
-
S
E
--
L
A
F
-
P
-
F
S
V
S
E
--
V
I
Q
M
G
R
A
P
------
Y
G
G
S
Q
D
R
Q
A
--
L
Q
Q
V
M
A
Q
T
--
D
C
L
A
-
L
A
-
Q
----
R
D
Y
R
V
L
S
G
G
E
Q
Q
R
V
Q
L
A
R
V
L
A
Q
L
WQPQP
T
P
R
W
L
F
L
D
E
P
T
S
A
L
D
L
Y
H
Q
Q
H
T
L
R
L
L
R
Q
L
T
R
-
Q
-
E
--
P
L
-
A
V
-
C
C
V
L
H
D
L
N
L
A
A
L
Y
A
D
R
I
-
M
L
L
-
A
-
Q
G
K
L
V
A
C
G
T
P
E
E
V
L
N
A
E
T
L
T
Q
W
Y
----------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
87.41
33%
-131
- C1 -
4G1U
1
HMUV_YERPE
D:
[12-245]
----
L
E
A
S
H
L
H
Y
H
V
--
Q
----
Q
----
Q
A
-
L
I
N
D
V
S
L
H
I
A
S
G
E
M
V
A
I
I
G
P
N
G
A
G
K
S
T
L
L
R
L
L
T
G
Y
L
S
P
S
H
G
E
C
--------
H
--------
L
-
L
------
G
---
Q
-----
N
L
-
N
------------------
S
--
W
--
Q
P
-------
K
---
A
LARTR
A
V
M
R
Q
Y
-
S
E
--
L
A
F
-
P
-
F
S
V
S
E
--
V
I
Q
M
G
R
A
P
------
Y
G
G
S
Q
D
R
Q
A
--
L
Q
Q
V
M
A
Q
T
--
D
C
L
A
-
L
A
-
Q
----
R
D
Y
R
V
L
S
G
G
E
Q
Q
R
V
Q
L
A
R
V
L
A
Q
LWQPQP
T
P
R
W
L
F
L
D
E
P
T
S
A
L
D
L
Y
H
Q
Q
H
T
L
R
L
L
R
Q
L
T
R
-
Q
-
E
--
P
L
-
A
V
-
C
C
V
L
H
D
L
N
L
A
A
L
Y
A
D
R
I
-
M
L
L
-
A
-
Q
G
K
L
V
A
C
G
T
P
E
E
V
L
N
A
E
T
L
T
Q
W
Y
----------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
86.20
31%
-117
- C1 -
4QC2
2
?
B:
[7-234]
-------
K
N
L
A
K
A
Y
--
K
----
G
----
R
R
-
V
V
E
D
V
S
L
T
V
N
S
G
E
I
V
G
L
L
G
P
N
G
A
G
K
T
T
T
F
Y
M
V
V
G
I
V
P
R
D
A
G
N
I
--------
I
--------
I
-
D
------
D
---
D
DISLL
P
L
H
A
------------------
R
--
A
--
R
R
-------
G
---
I
-----
G
Y
L
P
Q
---
E
A
S
I
F
R
-
R
-
L
S
V
Y
D
NL
M
A
V
L
Q
I
R
D
D
L
S
A
E
Q
R
E
D
R
-------
A
N
E
L
M
E
E
F
--
H
I
E
H
-
L
R
-
D
----
S
M
G
Q
S
L
S
G
G
E
R
R
R
V
E
I
A
R
A
L
A
A
------
N
P
K
F
I
L
L
D
E
P
F
A
G
V
D
P
I
S
V
I
D
I
K
R
I
I
E
H
L
-
R
-
D
-
S
--
G
L
-
G
V
-
L
I
T
D
H
N
V
R
E
T
L
A
V
C
E
R
A
-
Y
I
V
-
S
-
Q
G
H
L
I
A
H
G
T
P
T
E
I
L
Q
D
E
H
V
K
R
V
Y
----------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
85.58
31%
-118
- C1 -
4QC2
2
?
A:
[7-234]
-------
K
N
L
A
K
A
Y
--
K
----
G
----
R
R
-
V
V
E
D
V
S
L
T
V
N
S
G
E
I
V
G
L
L
G
P
N
G
A
G
K
T
T
T
F
Y
M
V
V
G
I
V
P
R
D
A
G
N
I
--------
I
--------
I
-
D
------
D
---
D
DISLL
P
L
H
A
------------------
R
--
A
--
R
R
-------
G
---
I
-----
G
Y
L
P
Q
---
E
A
S
I
F
R
-
R
-
L
S
V
Y
D
N
L
M
A
V
L
Q
I
R
D
D
L
S
A
E
Q
R
E
D
R
-------
A
N
E
L
M
E
E
F
--
H
I
E
H
-
L
R
-
D
----
S
M
G
Q
S
L
S
G
G
E
R
R
R
V
E
I
A
R
A
L
A
A
------
N
P
K
F
I
L
L
D
E
P
F
A
G
V
D
P
I
S
V
I
D
I
K
R
I
I
E
H
L
-
R
-
D
-
S
--
G
L
-
G
V
-
L
I
T
D
H
N
V
R
E
T
L
A
V
C
E
R
A
-
Y
I
V
-
S
-
Q
G
H
L
I
A
H
G
T
P
T
E
I
L
Q
D
E
H
V
K
R
V
Y
----------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
84.54
31%
-125
- C1 -
4P32
2
LPTB_ECOLI
A:
[6-233]
-------
K
N
L
A
K
A
Y
--
K
----
G
----
R
R
-
V
V
E
D
V
S
L
T
V
N
S
G
E
I
V
G
L
L
G
P
N
G
A
G
K
T
T
T
F
Y
M
V
V
G
I
V
P
R
D
A
G
N
I
--------
I
--------
I
-
D
------
D
---
D
DISLL
P
L
H
A
------------------
R
--
A
--
R
R
-------
G
---
I
-----
G
Y
L
P
Q
---
E
A
S
I
F
R
-
R
-
L
S
V
Y
D
N
L
M
A
V
L
Q
I
R
D
D
L
S
A
E
Q
R
E
D
R
-------
A
N
E
L
M
E
E
F
--
H
I
E
H
-
L
R
-
D
----
S
M
G
Q
S
L
S
G
G
E
R
R
R
V
E
I
A
R
A
L
A
A
------
N
P
K
F
I
L
L
D
E
P
F
A
G
V
D
P
I
S
V
I
D
I
K
R
I
I
E
H
L
-
R
-
D
-
S
--
G
L
-
G
V
-
L
I
T
D
H
N
V
R
E
T
L
A
V
C
E
R
A
-
Y
I
V
-
S
-
Q
G
H
L
I
A
H
G
T
P
T
E
I
L
Q
D
E
H
V
K
R
V
Y
----------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
84.24
30%
-124
- C1 -
4P33
7
LPTB_ECOLI
A:
[6-233]
-------
K
N
L
A
K
A
Y
--
K
----
G
----
R
R
-
V
V
E
D
V
S
L
T
V
N
S
G
E
I
V
G
L
L
G
P
N
G
A
G
K
T
T
T
F
Y
M
V
V
G
I
V
P
R
D
A
G
N
I
--------
I
--------
I
-
D
------
D
---
D
DISLL
P
L
H
A
------------------
R
--
A
--
R
R
-------
G
---
I
-----
G
Y
L
P
Q
---
E
A
S
I
F
R
-
R
-
L
S
V
Y
D
N
L
M
A
V
L
Q
I
R
D
D
L
S
A
E
Q
R
E
D
R
-------
A
N
E
L
M
E
E
F
--
H
I
E
H
-
L
R
-
D
----
S
M
G
Q
S
L
S
G
G
E
R
R
R
V
E
I
A
R
A
L
A
A
------
N
P
K
F
I
L
L
D
Q
P
F
A
G
V
D
P
I
S
V
I
D
I
K
R
I
I
E
H
L
-
R
-
D
-
S
--
G
L
-
G
V
-
L
I
T
D
H
N
V
R
E
T
L
A
V
C
E
R
A
-
Y
I
V
-
S
-
Q
G
H
L
I
A
H
G
T
P
T
E
I
L
Q
D
E
H
V
K
R
V
Y
----------------------------------------------------------------------------------------------------------------------
42
Fugue
84.21
31%
-110
- C1 -
1Z47
1
?
A:
[11-355]
GSMT
I
E
F
V
G
V
E
K
I
Y
--
P
----
G
----
G
A
R
S
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
--------
W
--------
I
-
G
------
G
---
K
-----
R
V
-
T
------------------
D
--
L
--
P
P
-------
Q
KRN
V
-----
G
L
V
F
Q
N
---
Y
A
L
F
Q
-
H
-
M
T
V
Y
D
--
N
V
S
F
G
L
R
E
K
----
R
V
P
K
D
E
M
D
A
R
--
V
R
E
L
L
R
F
M
--
R
L
E
S
-
Y
A
-
N
----
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
------
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
-
H
-
D
-
E
M
-
G
V
-
T
S
-
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
-
L
V
L
-
H
-
E
------
G
N
V
E
Q
F
G
T
P
E
E
V
Y
E
K
P
G
T
L
F
V
A
S
F
I
G
E
S
N
V
W
T
R
A
V
Q
NG
R
I
E
V
AG
A
A
L
P
V
DPAVSEG
S
E
V
A
V
V
V
R
PKD
V
E
L
Q
P
A
S
EREAHAQVV
R
S
A
F
KGS
Y
S
A
C
W
I
R
T
KD
G
E
V
W
E
V
H
V
P
SADRHRWSPG
A
W
V
H
M
N
V
T
R
W
F
I
F
P
R
22
PsiBlast_CBE
83.32
31%
-127
- C1 -
4P32
2
LPTB_ECOLI
B:
[6-230]
-------
K
N
L
A
K
A
Y
--
K
----
G
----
R
R
-
V
V
E
D
V
S
L
T
V
N
S
G
E
I
V
G
L
L
G
P
N
G
A
G
K
T
T
T
F
Y
M
V
V
G
I
V
P
R
D
A
G
N
I
--------
I
--------
I
-
D
------
D
---
D
DISLL
P
L
H
A
------------------
R
--
A
--
R
R
-------
G
---
I
-----
G
Y
L
P
Q
---
E
A
S
I
F
R
-
R
-
L
S
V
Y
D
NL
M
A
V
L
Q
I
R
D
D
L
S
A
E
Q
R
E
D
R
-------
A
N
E
L
M
E
E
F
--
H
I
E
H
-
L
R
-
D
----
S
M
G
Q
S
L
S
G
G
E
R
R
R
V
E
I
A
R
A
L
A
A
------
N
P
K
F
I
L
L
D
E
P
F
A
G
V
D
P
I
S
V
I
D
I
K
R
I
I
E
H
L
-
R
-
D
-
S
--
G
L
-
G
V
-
L
I
T
D
H
N
V
R
E
T
L
A
V
C
E
R
A
-
Y
I
V
-
S
-
Q
G
H
L
I
A
H
G
T
P
T
E
I
L
Q
D
E
H
V
K
-------------------------------------------------------------------------------------------------------------------------
37
Fugue
82.66
28%
-124
- C1 -
3TUZ
3
METN_ECOLI
H:
[23-362]
--HM
I
K
L
S
N
I
T
K
V
F
--
H
QGTR
T
----
I
Q
-
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
--------
L
VDGQELTT
L
-
S
------
E
---
S
-----
E
L
-
T
------------------
K
--
A
--
R
R
-------
Q
---
I
-----
G
M
I
F
Q
H
-
F
--
N
L
L
S
-
S
-
R
T
V
F
G
--
N
V
A
L
----
P
L
E
L
D
N
T
P
K
D
E
V
K
R
R
--
V
T
E
L
L
S
L
V
--
G
L
G
D
-
K
H
-
D
----
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
------
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
-
N
-
R
-
R
L-
G
L
-
T
I
-
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
-
A
V
I
-
S
-
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
I
PEDYQERLQAEPFTDCVPMLRLEFTGQSVDAPLLSETARRFNVNNNIISAQMDYAGGVKFGIMLTEMHGTQQDTQAAIAWLQEHHVKVEV-----------------
51
HHSearch
82.01
29%
-119
* C1 *
3TUI
1
METN_ECOLI
C:
[25-256]
----
I
K
L
S
N
I
T
K
V
F
--
H
----
Q
GTRT
I
Q
-
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
--------
L
--------
V
-
D
------
G
---
Q
-----
E
L
-
T
TLSESELT----------
K
--
A
--
R
R
-------
Q
---
I
-----
G
M
I
F
Q
H
-
F
N
L
--
L
S
-
S
-
R
T
V
F
G
--
N
V
A
L
P
L
E
L
D
N
T
----
P
K
D
E
V
K
R
R
--
V
T
E
L
L
S
L
V
--
G
L
G
D
-
K
H
-
D
----
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
------
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
-
N
-
R
R
L
--
G
L
-
T
I
-
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
-
A
V
I
S
N
-
G
-
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
---------------------------------------------------------------------------------------------------------------------------
63
HHSearch
81.99
29%
-134
- C1 -
2NQ2
-
Y1470_HAEIN
C:
[5-226]
----
L
S
V
E
N
L
G
F
Y
Y
--
Q
A---
E
----
N
F
-
L
F
Q
Q
L
N
F
D
L
N
K
G
D
I
L
A
V
L
G
Q
N
G
C
G
K
S
T
L
L
D
L
L
L
G
I
H
R
P
I
Q
G
K
I
--------
E
--------
V
-
Y
---------------------------------------------
Q
-------
S
---
I
-----
G
F
V
P
Q
F
-
F
S
--
S
P
F
-
A
-
Y
S
V
L
D
--
I
V
L
M
G
R
S
T
H
I
N
T
F
A
K
P
K
S
H
D
Y
Q
V
--
A
M
Q
A
L
D
Y
L
--
N
L
T
H
-
L
A
-
K
----
R
E
F
T
S
L
S
G
G
Q
R
Q
L
I
L
I
A
R
A
I
A
S
------
E
C
K
L
I
L
L
D
E
P
T
S
A
L
D
L
A
N
Q
D
I
V
L
S
L
L
I
D
L
-
A
-
Q
S
Q
--
N
M
-
T
V
-
V
F
T
T
H
Q
P
N
Q
V
V
A
I
A
N
K
T
-
L
L
L
-
N
-
K
-
Q
N
F
K
F
G
E
T
R
N
I
L
T
S
E
N
L
T
A
L
F
H
---------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
79.53
28%
-141
- C1 -
2NQ2
-
Y1470_HAEIN
C:
[5-221]
----
L
S
V
E
N
L
G
F
Y
Y
--
Q
A---
E
----
N
F
-
L
F
Q
Q
L
N
F
D
L
N
K
G
D
I
L
A
V
L
G
Q
N
G
C
G
K
S
T
L
L
D
L
L
L
G
I
H
R
P
I
Q
G
K
I
--------
E
--------
V
----------------------------------------------
Y
Q
-------
S
---
I
-----
G
F
V
P
Q
F
---
F
S
S
P
F
-
A
-
Y
S
V
L
D
--
I
V
L
M
G
R
S
T
H
I
N
T
F
A
K
P
K
S
H
D
Y
Q
V
--
A
M
Q
A
L
D
Y
L
--
N
L
T
H
-
L
A
-
K
----
R
E
F
T
S
L
S
G
G
Q
R
Q
L
I
L
I
A
R
A
I
A
S
------
E
C
K
L
I
L
L
D
E
P
T
S
A
L
D
L
A
N
Q
D
I
V
L
S
L
L
I
D
L
A
Q
-
S
-
Q
--
N
M
-
T
V
-
V
F
T
T
H
Q
P
N
Q
V
V
A
I
A
N
K
T
-
L
L
L
-
N
-
K
-
Q
N
F
K
F
G
E
T
R
N
I
L
T
S
E
N
L
--------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
79.48
27%
-132
- C1 -
3GFO
1
ECFA3_CLOP1
A:
[8-237]
----
L
K
V
E
E
L
N
Y
N
Y
--
S
----
D
----
G
T
H
A
L
K
G
I
N
M
N
I
K
R
G
E
V
T
A
I
L
G
G
N
G
V
G
K
S
T
L
F
Q
N
F
N
G
I
L
K
P
S
S
G
R
I
--------
L
--------
F
-
D
------
N
---
K
-----
P
I
-
D
------------------
Y
--
S
--
R
K
G
I
M
K
L
R
E
S
---
I
-----
G
I
V
F
Q
D
-
P
D
N
Q
L
-
F
-
S
-
A
S
V
Y
Q
--
D
V
S
F
G
A
V
N
----
M
K
L
P
E
D
E
I
R
K
R
--
V
D
N
A
L
K
R
T
--
G
I
E
H
-
L
K
-
D
----
K
P
T
H
C
L
S
F
G
Q
K
K
R
V
A
I
A
G
V
L
V
M
------
E
P
K
V
L
I
L
D
E
P
T
A
G
L
D
P
M
G
V
S
E
I
M
K
L
L
V
E
M
Q
K
-
E
-
L
--
G
I
-
T
I
-
I
I
A
T
H
D
I
D
I
V
P
L
Y
C
D
N
V
-
F
V
M
-
K
-
E
G
R
V
I
L
Q
G
N
P
K
E
V
F
A
E
K
E
V
--------------------------------------------------------------------------------------------------------------------------
56
HHSearch
77.28
27%
-126
- C1 -
3GFO
1
ECFA3_CLOP1
A:
[8-239]
----
L
K
V
E
E
L
N
Y
N
Y
--
S
----
D
G---
T
H
-
A
L
K
G
I
N
M
N
I
K
R
G
E
V
T
A
I
L
G
G
N
G
V
G
K
S
T
L
F
Q
N
F
N
G
I
L
K
P
S
S
G
R
I
--------
L
--------
F
-
D
------
N
---
K
-----
P
I
-
D
YS
R
K
G
I
M
-----------
K
--
L
--
R
E
-------
S
---
I
-----
G
I
V
F
Q
D
-
P
D
N
-
Q
L
F
-
S
-
A
S
V
Y
Q
--
D
V
S
F
G
A
V
N
M
K
----
L
P
E
D
E
I
R
K
R
--
V
D
N
A
L
K
R
T
--
G
I
E
H
-
L
K
-
D
----
K
P
T
H
C
L
S
F
G
Q
K
K
R
V
A
I
A
G
V
L
V
M
------
E
P
K
V
L
I
L
D
E
P
T
A
G
L
D
P
M
G
V
S
E
I
M
K
L
L
V
E
M
-
Q
-
K
E
L
--
G
I
-
T
I
-
I
I
A
T
H
D
I
D
I
V
P
L
Y
C
D
N
V
-
F
V
M
K
E
-
G
-
R
V
I
L
Q
G
N
P
K
E
V
F
A
E
K
E
V
I
R
------------------------------------------------------------------------------------------------------------------------
61
HHSearch
76.60
29%
-121
- C1 -
1B0U
4
HISP_SALTY
A:
[7-246]
----
L
H
V
I
D
L
H
K
R
Y
--
G
----
G
----
H
E
-
V
L
K
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
E
K
P
S
E
G
A
I
--------
I
--------
V
-
N
------
G
---
Q
-----
N
I
-
N
L
V
R
D
KDGQLKVAD
K
N
Q
L
R
L
--
L
--
R
T
-------
R
---
L
-----
T
M
V
F
Q
H
-
F
N
---
L
W
S
H
-
M
T
V
L
E
--
N
V
M
E
A
P
I
Q
V
L
G
L
---
S
K
H
D
A
R
E
R
--
A
L
K
Y
L
A
K
V
--
G
I
D
E
-
R
A
Q
G
----
K
Y
P
V
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
------
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
L
R
I
M
Q
Q
L
-
A
-
E
-
E
--
G
K
-
T
M
-
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
-
I
F
L
H
Q
-
G
-
K
I
E
E
E
G
D
P
E
Q
V
F
G
N
P
Q
S
--------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
76.43
35%
-115
- C1 -
3TIF
7
Y796_METJA
A:
[20-230]
-----------------------------
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
DNIKTN
D
--------
L
-
D
------
D
---
D
-----
E
L
-
T
------------------
K
--
I
--
R
R
D
------
K
---
I
-----
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
-
A
-
L
E
N
V
E
--
L
P
L
I
F
K
Y
R
G
----
A
M
S
G
E
E
R
R
K
R
--
A
L
E
C
L
K
M
A
--
E
L
E
E
R
F
A
-
N
----
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
------
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
-
N
E
E
-
D
--
G
K
-
T
V
-
V
V
V
T
H
D
I
N
-
V
A
R
F
G
E
R
I
-
I
Y
L
--------
K
D
G
E
V
E
R
---
E
E
K
L
R
-------------------------------------------------------------------------------------------------------------------------
62
HHSearch
75.85
29%
-132
- C1 -
2IHY
1
?
A:
[22-256]
----
I
Q
L
D
Q
I
G
R
M
K
--
Q
----
G
----
K
T
-
I
L
K
K
I
S
W
Q
I
A
K
G
D
K
W
I
L
Y
G
L
N
G
A
G
K
T
T
L
L
N
I
L
N
A
Y
E
P
A
T
S
G
T
V
--------
N
--------
L
-
F
------
G
---
K
-----
M
P
--GYS
A
E
-------------
T
--
V
--
R
Q
-------
H
---
I
-----
G
F
V
S
H
S
-
L
L
E
K
F
Q
E
-
G
-
E
R
V
I
D
--
V
V
I
S
G
A
---------
I
D
D
E
I
R
N
E
--
A
H
Q
L
L
K
L
V
--
G
M
S
A
-
K
A
-
Q
----
Q
Y
I
G
Y
L
S
T
G
E
K
Q
R
V
M
I
A
R
A
L
M
G
------
Q
P
Q
V
L
I
L
D
E
P
A
A
G
L
D
F
I
A
R
E
S
L
L
S
I
L
D
S
L
-
S
-
D
-
S
Y
P
T
L
-
A
M
-
I
Y
V
T
H
F
I
E
E
I
T
A
N
F
S
K
I
-
L
L
L
K
D
-
G
-
Q
S
I
Q
Q
G
A
V
E
D
I
L
T
S
E
N
M
--------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
75.78
31%
-123
- C1 -
3DHW
-
METN_ECOLI
C:
[20-237]
-----------------------------
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
LVDGQELT
T
--------
L
-
S
------
E
---
S
-----
E
L
-
T
------------------
K
--
A
--
R
R
-------
Q
---
I
-----
G
M
I
F
Q
H
---
F
N
L
L
S
-
S
-
R
T
V
F
G
--
N
V
A
L
----
P
L
E
L
D
N
T
P
K
D
E
V
K
R
R
--
V
T
E
L
L
S
L
V
--
G
L
G
D
-
K
H
-
D
----
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
------
N
P
K
V
L
L
C
D
E
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
-
R
-
L
--
G
L
-
T
I
-
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
-
N
-
G
-
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
-----------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
75.42
31%
-114
- C1 -
4HUQ
-
ECFA1_LACBA
B:
[6-228]
----
I
S
V
D
H
L
T
Y
Q
Y
DE
N
----
Q
----
A
P
-
A
L
T
D
V
S
F
T
V
H
A
G
E
W
L
A
I
V
G
H
N
G
S
G
K
S
T
L
A
K
S
L
D
G
L
L
P
F
T
Q
G
S
V
--------
T
--------
V
-
G
------
G
ITL
T
-----
P
E
-
T
------------------
V
--
W
Q
V
R
E
-------
Q
---
I
-----
G
M
I
F
Q
N
-
P
D
N
Q
F
-
V
-
G
-
A
T
V
E
D
--
D
V
------
A
F
G
L
E
N
R
Q
I
S
R
D
E
M
V
P
R
V
Q
A
A
L
A
Q
V
--
G
M
T
S
-
F
A
-
Q
----
R
E
P
S
S
L
S
G
G
Q
K
Q
R
V
A
L
A
G
I
V
A
I
------
A
P
K
I
L
I
L
D
E
A
T
S
M
L
D
P
Q
G
R
I
E
M
L
A
I
V
R
Q
L
-
R
-
Q
-
Q
--
Q
N
L
T
V
-
I
S
I
T
H
D
I
D
E
A
A
S
A
D
R
V
L
-
V
I
D
-
D
-
G
-
R
L
V
D
E
A
V
P
S
Q
I
F
-------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
74.99
35%
-121
- C1 -
3TIF
6
Y796_METJA
B:
[20-230]
-----------------------------
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
YIDNIKTN
D
--------
L
-
D
------
D
---
D
-----
E
L
-
T
------------------
K
--
I
--
R
R
D------
K
---
I
-----
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
-
A
-
L
E
N
V
E
--
L
P
L
I
F
K
Y
R
G
----
A
M
S
G
E
E
R
R
K
R
--
A
L
E
C
L
K
M
A
--
E
L
E
E
R
F
A
-
N
----
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
------
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
-
N
E
E
-
D
--
G
K
-
T
V
-
V
V
V
T
H
D
I
N
-
V
A
R
F
G
E
R
I
-
I
Y
L
--------
K
D
G
E
V
E
R
---
E
E
K
L
R
-------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
74.41
35%
-113
- C1 -
1L2T
4
Y796_METJA
A:
[20-230]
-----------------------------
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
DNIKTN
D
--------
L
-
D
------
D
---
D
-----
E
L
-
T
------------------
K
--
I
--
R
R
D
------
K
---
I
-----
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
-
A
-
L
E
N
V
E
--
L
P
L
I
F
K
Y
R
G
----
A
M
S
G
E
E
R
R
K
R
--
A
L
E
C
L
K
M
A
--
E
L
E
E
R
F
A
-
N
----
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
------
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
-
N
E
E
-
D
--
G
K
-
T
V
-
V
V
V
T
H
D
I
N
-
V
A
R
F
G
E
R
I
-
I
Y
L
--------
K
D
G
E
V
E
R
---
E
E
K
L
R
-------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
74.18
35%
-119
- C1 -
1L2T
4
Y796_METJA
B:
[20-230]
-----------------------------
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
YIDNIKTN
D
--------
L
-
D
------
D
---
D
-----
E
L
-
T
------------------
K
--
I
--
R
R
D------
K
---
I
-----
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
-
A
-
L
E
N
V
E
--
L
P
L
I
F
K
Y
R
G
----
A
M
S
G
E
E
R
R
K
R
--
A
L
E
C
L
K
M
A
--
E
L
E
E
R
F
A
-
N
----
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
------
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
-
N
E
E
-
D
--
G
K
-
T
V
-
V
V
V
T
H
D
I
N
-
V
A
R
F
G
E
R
I
-
I
Y
L
--------
K
D
G
E
V
E
R
---
E
E
K
L
R
-------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
73.27
35%
-117
- C1 -
1F3O
2
Y796_METJA
A:
[20-230]
-----------------------------
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
DNIKTN
D
--------
L
-
D
------
D
---
D
-----
E
L
-
T
------------------
K
--
I
--
R
R
D
------
K
---
I
-----
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
-
A
-
L
E
N
V
E
--
L
P
L
I
F
K
Y
R
G
A
----
M
S
G
E
E
R
R
K
R
--
A
L
E
C
L
K
M
A
--
E
L
E
E
R
F
A
-
N
----
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
------
N
P
P
I
I
L
A
D
E
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
-
N
E
E
-
D
--
G
K
-
T
V
-
V
V
V
T
H
D
I
N
-
V
A
R
F
G
E
R
I
-
I
Y
L
--------
K
D
G
E
V
E
R
---
E
E
K
L
R
-------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
72.13
30%
-130
- C1 -
4U00
3
?
A:
[20-230]
------------------------------
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
--------
V
--------
V
-
D
GLSVKD
D
---
R
-----
A
L
-
R
------------------
E
--
I
--
R
R
-------
E
---
V
-----
G
M
V
F
Q
Q
-
F
N
L
---
F
-
P
H
M
T
V
L
E
--
N
V
---
T
L
A
P
M
R
V
R
R
W
P
R
E
K
A
E
K
K
--
A
L
E
L
L
E
R
V
--
G
I
L
D
-
Q
A
-
R
----
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
------
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
-
A
-
Q
-
G
--
G
M
-
T
M
-
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
-
V
F
M
-
D
G
G
-
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
---------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
68.29
32%
-126
- C1 -
4MKI
4
ECFA2_CALS4
A:
[25-238]
---------------------------
V
-
A
L
K
D
I
N
F
S
I
D
D
E
E
F
V
G
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
G
L
L
K
P
S
K
G
K
I
Y
I
NGI---
D
--------
I
-
T
------
D
---
K
-----
K
V
-
S
------------------
L
K
D
I
--
R
K
-------
Q
---
V
-----
G
L
V
F
Q
Y
-
P
E
Y
Q
L
-
F
-
E
-
E
T
V
F
K
--
D
I
A
F
G
P
-
S
N
L
G
L
------
S
E
E
E
V
--
K
E
R
V
Y
E
A
M
--
E
I
V
G
-
I
S
-
K
ELAD
K
S
P
F
E
L
S
G
G
Q
K
R
R
V
A
I
A
G
I
L
A
M
------
R
P
K
I
L
I
L
D
E
P
T
A
G
L
D
P
K
G
K
Q
E
I
L
N
K
I
K
E
I
-
H
-
D
-
K
--
Y
K
-
M
I
T
I
L
V
S
H
N
M
E
D
I
A
R
I
A
D
K
I
-
I
V
M
-
N
-
R
G
K
I
E
L
I
G
T
P
R
E
V
F
R
E
-----------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
67.57
32%
-123
- C1 -
4MKI
4
ECFA2_CALS4
B:
[25-238]
---------------------------
V
-
A
L
K
D
I
N
F
S
I
D
D
E
E
F
V
G
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
G
L
L
K
P
S
K
G
K
I
Y
I
NGI---
D
--------
I
-
T
------
D
---
K
-----
K
V
-
S
------------------
L
K
D
I
--
R
K
-------
Q
---
V
-----
G
L
V
F
Q
Y
-
P
E
Y
Q
L
-
F
-
E
-
E
T
V
F
K
--
D
I
A
F
G
P
-
S
N
L
G
L
------
S
E
E
E
V
--
K
E
R
V
Y
E
A
M
--
E
I
V
G
-
I
S
-
K
ELAD
K
S
P
F
E
L
S
G
G
Q
K
R
R
V
A
I
A
G
I
L
A
M
------
R
P
K
I
L
I
L
D
E
P
T
A
G
L
D
P
K
G
K
Q
E
I
L
N
K
I
K
E
I
-
H
-
D
-
K
--
Y
K
-
M
I
T
I
L
V
S
H
N
M
E
D
I
A
R
I
A
D
K
I
-
I
V
M
-
N
-
R
G
K
I
E
L
I
G
T
P
R
E
V
F
R
E
-----------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
66.41
31%
-122
- C1 -
4HLU
2
ECFA2_THEMA
A:
[21-215]
---------------------
E
----
K
K
-
A
L
E
N
V
S
L
V
I
N
E
G
E
C
L
L
V
A
G
N
T
G
S
G
K
S
T
L
L
Q
I
V
A
G
L
I
E
P
T
S
G
D
V
--------
L
--------
Y
D
G
------
E
---
R
-----
K
K
-
G
------------------
Y
E
-
I
--
R
R
-------
N
---
I
-----
G
I
A
F
Q
Y
-
P
E
-
D
Q
F
F
-
A
-
E
R
V
F
D
--
E
V
A
F
A
V
K
N
F
Y
-----
P
D
R
D
P
V
P
L
--
V
K
K
A
M
E
F
V
GL
D
F
D
S
-
F
K
-
D
----
R
V
P
F
F
L
S
G
G
E
K
R
R
V
A
I
A
S
V
I
V
H
------
E
P
D
I
L
I
L
D
E
P
L
V
G
L
D
R
E
G
K
T
D
L
L
R
I
V
E
K
W
-
K
-
T
-
L
--
G
K
-
T
V
-
I
L
I
S
H
D
I
E
T
V
I
N
H
V
D
R
V
-
V
V
L
-
E
-
K
--------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
65.94
31%
-123
- C1 -
4HLU
3
ECFA2_THEMA
B:
[21-215]
---------------------
E
----
K
K
-
A
L
E
N
V
S
L
V
I
N
E
G
E
C
L
L
V
A
G
N
T
G
S
G
K
S
T
L
L
Q
I
V
A
G
L
I
E
P
T
S
G
D
V
--------
L
--------
Y
D
G
------
E
---
R
-----
K
K
-
G
------------------
Y
E-
I
--
R
R
-------
N
---
I
-----
G
I
A
F
Q
Y
-
P
E
-
D
Q
F
F
-
A
-
E
R
V
F
D
--
E
V
A
F
A
V
K
N
F
Y
-----
P
D
R
D
P
V
P
L
--
V
K
K
A
M
E
F
V
GL
D
F
D
S
-
F
K
-
D
----
R
V
P
F
F
L
S
G
G
E
K
R
R
V
A
I
A
S
V
I
V
H
------
E
P
D
I
L
I
L
D
E
P
L
V
G
L
D
R
E
G
K
T
D
L
L
R
I
V
E
K
W
-
K
-
T
-
L
--
G
K
-
T
V
-
I
L
I
S
H
D
I
E
T
V
I
N
H
V
D
R
V
-
V
V
L
-
E
-
K
--------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
63.47
31%
-128
- C1 -
4ZIR
5
ECFA2_THEMA
A:
[20-214]
---------------------
E
----
K
K
-
A
L
E
N
V
S
L
V
I
N
E
G
E
C
L
L
V
A
G
N
T
G
S
G
K
S
T
L
L
Q
I
V
A
G
L
I
E
P
T
S
G
D
V
--------
L
--------
Y
D
G
------
E
----------
K
-
G
------------------
Y
E-
I
--
R
R
-------
N
---
I
-----
G
I
A
F
Q
Y
-
P
E
-
D
Q
F
F
-
A
-
E
R
V
F
D
--
E
V
A
F
A
V
K
N
F
Y
-----
P
D
R
D
P
V
P
L
--
V
K
K
A
M
E
F
V
GL
D
F
D
S
-
F
K
-
D
----
R
V
P
F
F
L
S
G
G
E
K
R
R
V
A
I
A
S
V
I
V
H
------
E
P
D
I
L
I
L
D
E
P
L
V
G
L
D
R
E
G
K
T
D
L
L
R
I
V
E
K
W
-
K
-
T
-
L
--
G
K
-
T
V
-
I
L
I
S
H
D
I
E
T
V
I
N
H
V
D
R
V
-
V
V
L
-
E
-
K
--------------------------------------------------------------------------------------------------------------------------------------------