@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo1976: (2016-03-30 )
MNPFLKNKTVLITGASNGLGAEIARQVAMSGGNVIITARSTKKLIELQKDIHDKFSVEATYFTLDMTDFEQVKQVSAEINASYQIDVLVNCAGFGLFENAIDIPFETIEKMFDTNVLGLIQLTQLILPQMQARKAGHIINIASQAAKIATPKSTVYSATKYAVLGFSNALRLELMPDKINVTTINPGPIATNFFDVADKSSNYLETVGKLVLKPEKVAHKTVQIMGTKRREINLPFVMNIATRLYQVMPQVIEFFGKGAFLKK
Atome Classification :
(27 SA)
.........10........20.....-...30..--......40......--------..50......---..60..-......70...-.....80..-.-.....90..---...-...100........110.......120.......--130.......140.......150.......160.......170.......180.....----..-190---....-----.-...200------..------.-.-----.....210.......220.......230.......240.......250.......260.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MNPFLKN
K
T
V
L
I
TGASNG
L
G
A
E
I
A
R
Q
-
V
A
MSGG
N
--
V
I
I
T
AR
S
T
K
K
L
I
E
L
--------
Q
K
D
I
HDKF
S
V
---
E
A
T
Y
F
T
-LDMT
D
F
E
Q
V
K
Q
-
V
S
A
EINA
S
Y
-
Q
-
I
D
V
L
V
NCAG---F
G
L
-
F
E
N
AI-DI
P
F
E
T
I
E
K
M
FDT
N
V
L
G
L
I
Q
L
T
Q
L
I
L
P
Q
--
M
Q
A
R
KAG
H
I
I
N
I
A
S
Q
A
AKIATPK
S
T
VYSA
T
K
Y
A
V
L
GFS
N
A
L
R
L
E
LMPDK
I
N
V
T
TINPG----PI-AT----
N
F
F
D-----V-ADKS--------S
N
------
Y
-
L
-----
E
T
V
G
K
L
VL
K
P
E
K
V
A
H
K
T
V
Q
I
MGTKRREINL
P
F
V
M
N
I
A
T
R
L
Y
Q
V
M
P
Q
V
I
E
F
FGKGAFLKK
28
PsiBlast_CBE
82.24
34%
-97
- C1 -
3ASV
2
?
B:
[3-242]
---------
V
L
V
T
G
A
T
A
G
F
G
E
C
I
T
R
R
-
F
I
Q
Q
G
H
K
--
V
I
A
T
G
R
R
Q
E
R
L
Q
E
L
--------
K
D
E
L
G
D
N
L
Y
I
---
A
----
Q
-
L
D
V
R
N
R
A
A
I
E
E
-
M
L
A
S
L
P
A
E
W
C
N
-
I
D
I
L
V
N
N
A
G
---
L
A
L
G
M
E
P
A
H
-
K
A
S
V
E
D
W
E
T
M
I
D
T
N
N
K
G
L
V
Y
M
T
R
A
V
L
P
G
--
M
V
E
R
N
H
G
H
I
I
N
I
G
S
T
A
G
S
W
P
Y
A
G
G
N
V
Y
G
A
T
K
A
F
V
R
Q
F
S
L
N
L
R
T
D
L
H
G
T
A
V
R
V
T
D
I
E
P
G
----
L
V
G
G
T
----
E
F
S
N
-----
V
-
R
F
K
G
--------
D
D
GKAEKT
Y
-
Q
-----
N
T
V
---
A
L
T
P
E
D
V
S
E
A
V
W
W
V
S
-------
T
L
P
A
H
V
N
I
N
T
--
L
E
M
M
P
V
T
Q
S
Y
A
G
-------
24
PsiBlast_CBE
80.96
34%
-96
- C1 -
3ASV
2
?
F:
[3-242]
---------
V
L
V
T
G
A
T
A
G
F
G
E
C
I
T
R
R
-
F
I
Q
Q
G
H
K
--
V
I
A
T
G
R
R
Q
E
R
L
Q
E
L
--------
K
D
E
L
G
D
N
L
Y
I
---
A
----
Q
-
L
D
V
R
N
R
A
A
I
E
E
-
M
L
A
S
L
P
A
E
W
C
N
-
I
D
I
L
V
N
N
A
G
---
L
A
L
G
M
E
P
A
H
-
K
A
S
V
E
D
W
E
T
M
I
D
T
N
N
K
G
L
V
Y
M
T
R
A
V
L
P
G
--
M
V
E
R
N
H
G
H
I
I
N
I
G
S
T
A
G
S
W
P
Y
A
G
G
N
V
Y
G
A
T
K
A
F
V
R
Q
F
S
L
N
L
R
T
D
L
H
G
T
A
V
R
V
T
D
I
E
P
G
----
L
V
G
G
T
----
E
F
S
N
-----
V
-
R
F
K
G
--------
D
D
GKAEKT
Y
-
Q
-----
N
T
V
---
A
L
T
P
E
D
V
S
E
A
V
W
W
V
S
-------
T
L
P
A
H
V
N
I
N
T
--
L
E
M
M
P
V
T
Q
S
Y
A
G
-------
3
PsiBlast_PDB
80.51
34%
-92
- C1 -
3ASV
2
?
A:
[3-242]
---------
V
L
V
T
G
A
T
A
G
F
G
E
C
I
T
R
R
-
F
I
Q
Q
G
H
K
--
V
I
A
T
G
R
R
Q
E
R
L
Q
E
L
--------
K
D
E
L
G
D
N
L
Y
I
---
A
----
Q
-
L
D
V
R
N
R
A
A
I
E
E
-
M
L
A
S
L
P
A
E
W
C
N
-
I
D
I
L
V
N
N
A
G
---
L
A
L
G
M
E
P
A
H
-
K
A
S
V
E
D
W
E
T
M
I
D
T
N
N
K
G
L
V
Y
M
T
R
A
V
L
P
G
--
M
V
E
R
N
H
G
H
I
I
N
I
G
S
T
A
G
S
W
P
Y
A
G
G
N
V
Y
G
A
T
K
A
F
V
R
Q
F
S
L
N
L
R
T
D
L
H
G
T
A
V
R
V
T
D
I
E
P
G
----
L
V
G
G
T
----
E
F
S
N
-----
V
-
R
F
K
G
--------
D
D
G
K
A
E
K
T
Y
-
Q
-----
N
T
V
---
A
L
T
P
E
D
V
S
E
A
V
W
W
V
S
-------
T
L
P
A
H
V
N
I
N
T
--
L
E
M
M
P
V
T
Q
S
Y
A
G
-------
26
PsiBlast_CBE
80.39
34%
-96
- C1 -
3ASV
2
?
D:
[3-242]
---------
V
L
V
T
G
A
T
A
G
F
G
E
C
I
T
R
R
-
F
I
Q
Q
G
H
K
--
V
I
A
T
G
R
R
Q
E
R
L
Q
E
L
--------
K
D
E
L
G
D
N
L
Y
I
---
A
----
Q
-
L
D
V
R
N
R
A
A
I
E
E
-
M
L
A
S
L
P
A
E
W
C
N
-
I
D
I
L
V
N
N
A
G
---
L
A
L
G
M
E
P
A
H
-
K
A
S
V
E
D
W
E
T
M
I
D
T
N
N
K
G
L
V
Y
M
T
R
A
V
L
P
G
--
M
V
E
R
N
H
G
H
I
I
N
I
G
S
T
A
G
S
W
P
Y
A
G
G
N
V
Y
G
A
T
K
A
F
V
R
Q
F
S
L
N
L
R
T
D
L
H
G
T
A
V
R
V
T
D
I
E
P
G
----
L
V
G
G
T
----
E
F
S
N
-----
V
-
R
F
K
G
--------
D
D
GKAEKT
Y
-
Q
-----
N
T
V
---
A
L
T
P
E
D
V
S
E
A
V
W
W
V
S
-------
T
L
P
A
H
V
N
I
N
T
--
L
E
M
M
P
V
T
Q
S
Y
A
G
-------
27
PsiBlast_CBE
80.24
34%
-97
- C1 -
3ASV
2
?
C:
[3-242]
---------
V
L
V
T
G
A
T
A
G
F
G
E
C
I
T
R
R
-
F
I
Q
Q
G
H
K
--
V
I
A
T
G
R
R
Q
E
R
L
Q
E
L
--------
K
D
E
L
G
D
N
L
Y
I
---
A
----
Q
-
L
D
V
R
N
R
A
A
I
E
E
-
M
L
A
S
L
P
A
E
W
C
N
-
I
D
I
L
V
N
N
A
G
---
L
A
L
G
M
E
P
A
H
-
K
A
S
V
E
D
W
E
T
M
I
D
T
N
N
K
G
L
V
Y
M
T
R
A
V
L
P
G
--
M
V
E
R
N
H
G
H
I
I
N
I
G
S
T
A
G
S
W
P
Y
A
G
G
N
V
Y
G
A
T
K
A
F
V
R
Q
F
S
L
N
L
R
T
D
L
H
G
T
A
V
R
V
T
D
I
E
P
G
----
L
V
G
G
T
----
E
F
S
N
-----
V
-
R
F
K
G
--------
D
D
GKAEKT
Y
-
Q
-----
N
T
V
---
A
L
T
P
E
D
V
S
E
A
V
W
W
V
S
-------
T
L
P
A
H
V
N
I
N
T
--
L
E
M
M
P
V
T
Q
S
Y
A
G
-------
25
PsiBlast_CBE
80.22
34%
-98
- C1 -
3ASV
2
?
E:
[3-242]
---------
V
L
V
T
G
A
T
A
G
F
G
E
C
I
T
R
R
-
F
I
Q
Q
G
H
K
--
V
I
A
T
G
R
R
Q
E
R
L
Q
E
L
--------
K
D
E
L
G
D
N
L
Y
I
---
A
----
Q
-
L
D
V
R
N
R
A
A
I
E
E
-
M
L
A
S
L
P
A
E
W
C
N
-
I
D
I
L
V
N
N
A
G
---
L
A
L
G
M
E
P
A
H
-
K
A
S
V
E
D
W
E
T
M
I
D
T
N
N
K
G
L
V
Y
M
T
R
A
V
L
P
G
--
M
V
E
R
N
H
G
H
I
I
N
I
G
S
T
A
G
S
W
P
Y
A
G
G
N
V
Y
G
A
T
K
A
F
V
R
Q
F
S
L
N
L
R
T
D
L
H
G
T
A
V
R
V
T
D
I
E
P
G
----
L
V
G
G
T
----
E
F
S
N
-----
V
-
R
F
K
G
--------
D
D
GKAEKT
Y
-
Q
-----
N
T
V
---
A
L
T
P
E
D
V
S
E
A
V
W
W
V
S
-------
T
L
P
A
H
V
N
I
N
T
--
L
E
M
M
P
V
T
Q
S
Y
A
G
-------
2
PsiBlast_PDB
76.77
34%
-100
- C1 -
3ASU
-
?
A:
[3-240]
---------
V
L
V
T
G
A
T
A
G
F
G
E
C
I
T
R
R
-
F
I
Q
Q
G
H
K
--
V
I
A
T
G
R
R
Q
E
R
L
Q
E
L
--------
K
D
E
L
G
D
N
L
Y
I
---
A
----
Q
-
L
D
V
R
N
R
A
A
I
E
E
-
M
L
A
S
L
P
A
E
W
C
N
-
I
D
I
L
V
N
N
A
G
---
L
A
L
G
M
E
P
A
H
-
K
A
S
V
E
D
W
E
T
M
I
D
T
N
N
K
G
L
V
Y
M
T
R
A
V
L
P
G
--
M
V
E
R
N
H
G
H
I
I
N
I
G
S
T
A
G
S
W
P
Y
A
G
G
N
V
Y
G
A
T
K
A
F
V
R
Q
F
S
L
N
L
R
T
D
L
H
G
T
A
V
R
V
T
D
I
E
P
G
----
L
V
G
G
----------------------------------------------
V
---
A
L
T
P
E
D
V
S
E
A
V
W
W
V
S
-------
T
L
P
A
H
V
N
I
N
T
--
L
E
M
M
P
V
T
Q
S
Y
---------
4
PsiBlast_PDB
76.42
35%
-99
- C1 -
3M1A
-
?
A:
[6-213]
-------
K
V
W
L
V
T
G
A
S
S
G
F
G
R
A
I
A
E
A
-
A
V
A
A
G
D
T
--
V
I
G
T
A
R
R
T
E
A
L
D
D
L
--------
V
A
A
Y
P
D
R
-------
A
E
A
I
S
-
L
D
V
T
D
G
E
R
I
D
V
-
V
A
A
D
V
L
A
R
Y
G
R
-
V
D
V
L
V
N
N
A
G
R
T
Q
V
G
A
-
F
E
E
T
T
-
E
---
R
E
L
R
D
L
F
E
L
H
V
F
G
P
A
R
L
T
R
A
L
L
P
Q
--
M
R
E
R
G
S
G
S
V
V
N
I
S
S
F
G
G
Q
L
S
F
A
G
F
S
A
Y
S
A
T
K
A
A
L
E
Q
L
S
E
G
L
A
D
E
V
A
P
F
G
I
K
V
L
I
V
E
P
G
----
A
F
-
R
T
----
N
L
F
G
K
G
A
A
Y
F
-
S
E
E
N
--------
P
A
------
Y
-
A
-----
E
K
V
G
-------------------------------------------------------
1
PsiBlast_PDB
75.65
40%
-96
- C1 -
3RKU
1
YM71_YEAST
A:
[31-225]
----
L
A
K
K
T
V
L
I
T
G
A
S
A
G
I
G
K
A
T
A
L
E
Y
L
E
A
S
N
G
D
M
K
L
I
L
A
A
R
R
L
E
K
L
E
E
L
--------
K
K
T
I
D
Q
E
F
P
N
---
A
K
V
H
V
A
Q
L
D
I
T
Q
A
E
K
I
K
P
-
F
I
E
N
L
P
Q
E
F
-
K
D
I
D
I
L
V
N
N
A
G
---
K
A
L
-
G
S
D
R
V
G
Q
I
A
T
E
D
I
Q
D
V
F
D
T
N
V
T
A
L
I
N
I
T
Q
A
V
L
P
I
--
F
Q
A
K
N
S
G
D
I
V
N
L
G
S
I
A
G
R
D
A
Y
P
T
G
S
I
Y
C
A
S
K
F
A
V
G
A
F
T
D
S
L
R
K
E
L
I
N
T
K
I
R
V
I
L
I
A
P
G
----
L
V
-
E
T
----
E
F
------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
75.50
34%
-102
- C1 -
2JAP
2
?
A:
[3-192]
--
S
A
L
Q
G
K
V
A
L
I
T
G
A
S
S
G
I
G
E
A
T
A
R
A
-
L
A
A
E
G
A
A
--
V
A
I
A
A
R
R
V
E
K
L
R
A
L
--------
G
D
E
L
-
T
A
A
G
A
---
K
V
H
V
L
E
-
L
D
V
A
D
R
Q
G
V
D
A
A
V
A
S
T
V
E
A
L
G
-
G
-
L
D
I
L
V
N
N
A
G
---
I
M
L
-
L
G
P
V
E
-
D
A
D
T
T
D
W
T
R
M
I
D
T
N
L
L
G
L
M
Y
M
T
R
A
A
L
P
H
--
L
-
L
R
S
K
G
T
V
V
Q
M
S
S
I
A
G
R
V
N
V
R
N
A
A
V
Y
Q
A
T
K
F
G
V
N
A
F
S
E
T
L
R
Q
E
V
T
E
R
G
V
R
V
V
V
I
E
P
G
----
T
T
-
D
T
----
E
L
------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
75.48
34%
-103
- C1 -
2JAP
2
?
D:
[3-192]
--
S
A
L
Q
G
K
V
A
L
I
T
G
A
S
S
G
I
G
E
A
T
A
R
A
-
L
A
A
E
G
A
A
--
V
A
I
A
A
R
R
V
E
K
L
R
A
L
--------
G
D
E
L
-
T
A
A
G
A
---
K
V
H
V
L
E
-
L
D
V
A
D
R
Q
G
V
D
A
A
V
A
S
T
V
E
A
L
G
-
G
-
L
D
I
L
V
N
N
A
G
---
I
M
L
-
L
G
P
V
E
-
D
A
D
T
T
D
W
T
R
M
I
D
T
N
L
L
G
L
M
Y
M
T
R
A
A
L
P
H
--
L
-
L
R
S
K
G
T
V
V
Q
M
S
S
I
A
G
R
V
N
V
R
N
A
A
V
Y
Q
A
T
K
F
G
V
N
A
F
S
E
T
L
R
Q
E
V
T
E
R
G
V
R
V
V
V
I
E
P
G
----
T
T
-
D
T
----
E
L
------------------------------------------------------------------------------------------------
87
HHSearch
75.18
29%
-89
- C1 -
3AI3
3
?
A:
[1-254]
M
D
M
G
I
S
G
K
V
A
V
I
T
G
S
S
S
G
I
G
L
A
I
A
E
G
-
F
A
K
E
G
A
H
--
I
V
L
V
A
R
Q
V
D
R
L
H
E
A
--------
A
R
S
L
K
E
K
F
G
V
---
R
V
L
E
V
A
-
V
D
V
A
T
P
E
G
V
D
A
-
V
V
E
S
V
R
S
S
F
G
G
-
A
D
I
L
V
N
N
A
G
---
T
G
S
-
N
E
T
I
M
-
E
A
A
D
E
K
W
Q
F
Y
W
E
L
L
V
M
A
A
V
R
L
A
R
G
L
V
P
G
--
M
R
A
R
G
G
G
A
I
I
H
N
A
S
I
C
A
V
Q
P
L
W
Y
E
P
I
Y
N
V
T
K
A
A
L
M
M
F
S
K
T
L
A
T
E
V
I
K
D
N
I
R
V
N
C
I
N
P
G
----
L
I
-
L
T
----
P
D
W
I
-----
K
T
A
K
E
L
T
K
DNGGD
W
K
G
------
Y
L
Q
S
V
A
D
E
H
A
P
I
K
R
F
A
S
P
E
E
L
A
N
F
F
V
F
L
C
-
S
E
R
A
T
Y
S
V
G
S
A
Y
F
------------------------
21
PsiBlast_CBE
75.01
40%
-97
- C1 -
3RKU
1
YM71_YEAST
D:
[31-225]
----
L
A
K
K
T
V
L
I
T
G
A
S
A
G
I
G
K
A
T
A
L
E
Y
L
E
A
S
N
G
D
MK
L
I
L
A
A
R
R
L
E
K
L
E
E
L
--------
K
K
T
I
D
Q
E
F
P
N
---
A
K
V
H
V
A
Q
L
D
I
T
Q
A
E
K
I
K
P
-
F
I
E
N
L
P
Q
E
F
-
K
D
I
D
I
L
V
N
N
A
G
---
K
A
L
-
G
S
D
R
V
G
Q
I
A
T
E
D
I
Q
D
V
F
D
T
N
V
T
A
L
I
N
I
T
Q
A
V
L
P
I
--
F
Q
A
K
N
S
G
D
I
V
N
L
G
S
I
A
G
R
D
A
Y
P
T
G
S
I
Y
C
A
S
K
F
A
V
G
A
F
T
D
S
L
R
K
E
L
I
N
T
K
I
R
V
I
L
I
A
P
G
----
L
V
-
E
T
----
E
F
------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
74.39
34%
-102
- C1 -
2JAP
2
?
B:
[3-192]
--
S
A
L
Q
G
K
V
A
L
I
T
G
A
S
S
G
I
G
E
A
T
A
R
A
-
L
A
A
E
G
A
A
--
V
A
I
A
A
R
R
V
E
K
L
R
A
L
--------
G
D
E
L
-
T
A
A
G
A
---
K
V
H
V
L
E
-
L
D
V
A
D
R
Q
G
V
D
A
A
V
A
S
T
V
E
A
L
G
-
G
-
L
D
I
L
V
N
N
A
G
---
I
M
L
-
L
G
P
V
E
-
D
A
D
T
T
D
W
T
R
M
I
D
T
N
L
L
G
L
M
Y
M
T
R
A
A
L
P
H
--
L
-
L
R
S
K
G
T
V
V
Q
M
S
S
I
A
G
R
V
N
V
R
N
A
A
V
Y
Q
A
T
K
F
G
V
N
A
F
S
E
T
L
R
Q
E
V
T
E
R
G
V
R
V
V
V
I
E
P
G
----
T
T
-
D
T
----
E
L
------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
73.64
40%
-98
- C1 -
3RKU
1
YM71_YEAST
B:
[31-225]
----
L
A
K
K
T
V
L
I
T
G
A
S
A
G
I
G
K
A
T
A
L
E
Y
L
E
A
S
N
G
D
MK
L
I
L
A
A
R
R
L
E
K
L
E
E
L
--------
K
K
T
I
D
Q
E
F
P
N
---
A
K
V
H
V
A
Q
L
D
I
T
Q
A
E
K
I
K
P
-
F
I
E
N
L
P
Q
E
F
-
K
D
I
D
I
L
V
N
N
A
G
---
K
A
L
-
G
S
D
R
V
G
Q
I
A
T
E
D
I
Q
D
V
F
D
T
N
V
T
A
L
I
N
I
T
Q
A
V
L
P
I
--
F
Q
A
K
N
S
G
D
I
V
N
L
G
S
I
A
G
R
D
A
Y
P
T
G
S
I
Y
C
A
S
K
F
A
V
G
A
F
T
D
S
L
R
K
E
L
I
N
T
K
I
R
V
I
L
I
A
P
G
----
L
V
-
E
T
----
E
F
------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
73.29
34%
-100
- C1 -
2JAP
2
?
C:
[2-192]
-
P
S
A
L
Q
G
K
V
A
L
I
T
G
A
S
S
G
I
G
E
A
T
A
R
A
-
L
A
A
E
G
A
A
--
V
A
I
A
A
R
R
V
E
K
L
R
A
L
--------
G
D
E
L
-
T
A
A
G
A
---
K
V
H
V
L
E
-
L
D
V
A
D
R
Q
G
V
D
A
A
V
A
S
T
V
E
A
L
G
-
G
-
L
D
I
L
V
N
N
A
G
---
I
M
L
-
L
G
P
V
E
-
D
A
D
T
T
D
W
T
R
M
I
D
T
N
L
L
G
L
M
Y
M
T
R
A
A
L
P
H
--
L
-
L
R
S
K
G
T
V
V
Q
M
S
S
I
A
G
R
V
N
V
R
N
A
A
V
Y
Q
A
T
K
F
G
V
N
A
F
S
E
T
L
R
Q
E
V
T
E
R
G
V
R
V
V
V
I
E
P
G
----
T
T
-
D
T
----
E
L
------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
72.61
40%
-96
- C1 -
3RKU
1
YM71_YEAST
C:
[31-225]
----
L
A
K
K
T
V
L
I
T
G
A
S
A
G
I
G
K
A
T
A
L
E
Y
L
E
A
S
N
G
D
MK
L
I
L
A
A
R
R
L
E
K
L
E
E
L
--------
K
K
T
I
D
Q
E
F
P
N
---
A
K
V
H
V
A
Q
L
D
I
T
Q
A
E
K
I
K
P
-
F
I
E
N
L
P
Q
E
F
-
K
D
I
D
I
L
V
N
N
A
G
---
K
A
L
-
G
S
D
R
V
G
Q
I
A
T
E
D
I
Q
D
V
F
D
T
N
V
T
A
L
I
N
I
T
Q
A
V
L
P
I
--
F
Q
A
K
N
S
G
D
I
V
N
L
G
S
I
A
G
R
D
A
Y
P
T
G
S
I
Y
C
A
S
K
F
A
V
G
A
F
T
D
S
L
R
K
E
L
I
N
T
K
I
R
V
I
L
I
A
P
G
----
L
V
-
E
T
----
E
F
------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
71.82
31%
-99
- C1 -
4DC1
1
ACT3_STRCO
B:
[26-231]
------
S
E
V
A
L
V
T
G
A
T
S
G
I
G
L
E
I
A
R
R
-
L
G
K
E
G
L
R
--
V
F
V
C
A
R
G
E
E
G
L
R
T
T
--------
L
K
E
L
R
E
A
-
G
V
---
E
A
D
G
R
T
-
C
D
V
R
S
V
P
E
I
E
A
-
L
V
A
A
V
V
E
R
Y
-
G
P
V
D
V
L
V
N
N
A
G
---
R
P
G
-
G
G
A
T
A
-
E
L
A
D
E
L
W
L
D
V
V
E
T
N
L
T
G
V
F
R
V
T
K
Q
V
L
K
A
GG
M
L
E
R
G
T
G
R
I
V
N
I
A
S
T
G
G
K
Q
G
V
V
H
A
A
P
Y
S
A
S
K
H
G
V
V
G
F
T
K
A
L
G
L
E
L
A
R
T
G
I
T
V
N
A
V
C
P
G
FVET
P
M
-
A
A
S
V
R
E
H
F
S
D
-----
I
-
W
E
V
S
--------
T
E
-------------------------------------------------------------------------
6
PsiBlast_PDB
71.12
32%
-99
- C1 -
3AI2
1
?
A:
[1-192]
M
D
M
G
I
S
G
K
V
A
V
I
T
G
S
S
S
G
I
G
L
A
I
A
E
G
-
F
A
K
E
G
A
H
--
I
V
L
V
A
R
Q
V
D
R
L
H
E
A
--------
A
R
S
L
K
E
K
F
G
V
---
R
V
L
E
V
A
-
V
D
V
A
T
P
E
G
V
D
A
-
V
V
E
S
V
R
S
S
F
-
G
G
A
D
I
L
V
N
N
A
G
---
T
G
S
-
N
E
T
I
M
-
E
A
A
D
E
K
W
Q
F
Y
W
E
L
H
V
M
A
A
V
R
L
A
R
G
L
V
P
G
--
M
R
A
R
G
G
G
A
I
I
H
N
A
S
I
C
A
V
Q
P
L
W
Y
E
P
I
Y
N
V
T
K
A
A
L
M
M
F
S
K
T
L
A
T
E
V
I
K
D
N
I
R
V
N
C
I
N
P
G
----
L
I
-
L
T
------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
70.38
32%
-100
- C1 -
3AI2
1
?
B:
[1-192]
M
D
M
G
I
S
G
K
V
A
V
I
T
G
S
S
S
G
I
G
L
A
I
A
E
G
-
F
A
K
E
G
A
H
--
I
V
L
V
A
R
Q
V
D
R
L
H
E
A
--------
A
R
S
L
K
E
K
F
G
V
---
R
V
L
E
V
A
-
V
D
V
A
T
P
E
G
V
D
A
-
V
V
E
S
V
R
S
S
F
-
G
G
A
D
I
L
V
N
N
A
G
---
T
G
S
-
N
E
T
I
M
-
E
A
A
D
E
K
W
Q
F
Y
W
E
L
H
V
M
A
A
V
R
L
A
R
G
L
V
P
G
--
M
R
A
R
G
G
G
A
I
I
H
N
A
S
I
C
A
V
Q
P
L
W
Y
E
P
I
Y
N
V
T
K
A
A
L
M
M
F
S
K
T
L
A
T
E
V
I
K
D
N
I
R
V
N
C
I
N
P
G
----
L
I
-
L
T
------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
61.63
32%
-102
- C1 -
4QEC
3
?
B:
[3-187]
-------
K
N
V
L
I
T
G
G
F
K
G
I
G
K
Q
V
A
L
E
-
F
L
K
N
D
Y
H
--
V
C
I
T
S
R
----
Y
F
E
K
--------
E
K
R
I
P
H
L
F
S
S
YEE
N
I
S
F
Y
Q
-
L
D
V
T
D
E
E
Q
V
N
E
-
I
I
N
K
I
V
K
K
F
G
R
-
L
D
V
L
V
N
N
A
G
---
I
S
L
-
S
D
G
L
L
T
E
T
K
T
T
D
F
N
K
M
I
N
T
N
I
L
G
T
Y
F
C
M
K
Y
A
L
K
H
--
M
Q
K
V
S
C
G
A
I
V
N
I
S
S
I
T
G
L
S
G
F
P
Y
S
I
L
Y
G
S
T
K
H
A
V
I
G
L
T
K
G
A
A
V
E
F
A
D
K
G
I
K
I
N
A
V
A
P
G
----
I
I
-
K
T
------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
61.40
32%
-101
- C1 -
4QED
3
?
B:
[3-187]
-------
K
N
V
L
I
T
G
G
F
K
G
I
G
K
Q
V
A
L
E
-
F
L
K
N
D
Y
H
--
V
C
I
T
S
R
----
Y
F
E
K
--------
E
K
R
I
P
H
L
F
S
S
YEE
N
I
S
F
Y
Q
-
L
D
V
T
D
E
E
Q
V
N
E
-
I
I
N
K
I
V
K
K
F
G
R
-
L
D
V
L
V
N
N
A
G
---
I
S
L
-
S
D
G
L
L
T
E
T
K
T
T
D
F
N
K
M
I
N
T
N
I
L
G
T
Y
F
C
M
K
Y
A
L
K
H
--
M
Q
K
V
S
C
G
A
I
V
N
I
S
S
I
T
G
L
S
G
F
P
Y
S
I
L
F
G
S
T
K
H
A
V
I
G
L
T
K
G
A
A
V
E
F
A
D
K
G
I
K
I
N
A
V
A
P
G
----
I
I
-
K
T
------------------------------------------------------------------------------------------------------
65
PsiBlast_CBE
59.46
32%
-98
- C1 -
4QEC
3
?
A:
[3-187]
-------
K
N
V
L
I
T
G
G
F
K
G
I
G
K
Q
V
A
L
E
-
F
L
K
N
D
Y
H
--
V
C
I
T
S
R
----
Y
F
E
K
--------
E
K
R
I
P
H
L
F
S
S
YEE
N
I
S
F
Y
Q
-
L
D
V
T
D
E
E
Q
V
N
E
-
I
I
N
K
I
V
K
K
F
G
R
-
L
D
V
L
V
N
N
A
G
---
I
S
L
-
S
D
G
L
L
T
E
T
K
T
T
D
F
N
K
M
I
N
T
N
I
L
G
T
Y
F
C
M
K
Y
A
L
K
H
--
M
Q
K
V
S
C
G
A
I
V
N
I
S
S
I
T
G
L
S
G
F
P
Y
S
I
L
Y
G
S
T
K
H
A
V
I
G
L
T
K
G
A
A
V
E
F
A
D
K
G
I
K
I
N
A
V
A
P
G
----
I
I
-
K
T
------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
51.43
33%
-86
- C1 -
3P19
1
?
C:
[17-215]
-------
K
L
V
V
I
T
G
A
S
S
G
I
G
E
A
I
A
R
R
-
F
S
E
E
G
H
P
--
L
L
L
L
A
R
R
V
E
R
L
K
A
L
NLPNTLCA
Q
V
D
V
T
D
K
Y
T
--------
F
D
-
T
A
I
T
R
A
E
K
I
Y
G
-
P
A
-----------
D
A
I
V
N
N
A
G
---
M
M
L
-
L
G
Q
I
D
-
T
Q
E
A
N
E
W
Q
R
M
F
D
V
N
V
L
G
L
L
N
G
M
Q
A
V
L
A
P
--
M
K
A
R
N
C
G
T
I
I
N
I
S
S
I
A
G
K
K
T
F
P
D
H
A
A
Y
C
G
T
K
F
A
V
H
A
I
S
E
N
V
R
E
E
V
A
A
S
N
V
R
V
M
T
I
A
P
S
----
A
V
-
K
T
----
E
L
L
-----------------------------------------------------------------------------------------------
11
PsiBlast_PDB
50.23
33%
-83
- C1 -
3P19
1
?
A:
[17-197]
-------
K
L
V
V
I
T
G
A
S
S
G
I
G
E
A
I
A
R
R
-
F
S
E
E
G
H
P
--
L
L
L
L
A
R
R
V
E
R
L
K
A
L
NLPN
T
L
C
A
Q
V
D
V
T
D
K
Y
T
--------
F
D
-
T
A
I
T
R
A
E
K
I
Y
G
-
P
A
-----------
D
A
I
V
N
N
A
G
---
M
M
L
-
L
G
Q
I
D
-
T
Q
E
A
N
E
W
Q
R
M
F
D
V
N
V
L
G
L
L
N
G
M
Q
A
V
L
A
P
--
M
K
A
R
N
C
G
T
I
I
N
I
S
S
I
A
G
K
K
T
F
P
D
H
A
A
Y
C
G
T
K
F
A
V
H
A
I
S
E
N
V
R
E
E
V
A
A
S
N
V
R
V
M
T
I
A
P
S
----
A
V
-
K
T
----
E
L
L
-----------------------------------------------------------------------------------------------
42
PsiBlast_CBE
49.56
33%
-86
- C1 -
3P19
1
?
B:
[17-215]
-------
K
L
V
V
I
T
G
A
S
S
G
I
G
E
A
I
A
R
R
-
F
S
E
E
G
H
P
--
L
L
L
L
A
R
R
V
E
R
L
K
A
L
NLPN
T
L
C
A
Q
V
D
V
T
D
K
Y
T
--------
F
D
-
T
A
I
T
R
A
E
K
I
Y
G
-
P
A
-----------
D
A
I
V
N
N
A
G
---
M
M
L
-
L
G
Q
I
D
-
T
Q
E
A
N
E
W
Q
R
M
F
D
V
N
V
L
G
L
L
N
G
M
Q
A
V
L
A
P
--
M
K
A
R
N
C
G
T
I
I
N
I
S
S
I
A
G
K
K
T
F
P
D
H
A
A
Y
C
G
T
K
F
A
V
H
A
I
S
E
N
V
R
E
E
V
A
A
S
N
V
R
V
M
T
I
A
P
S
----
A
V
-
K
T
----
E
L
L
-----------------------------------------------------------------------------------------------
40
PsiBlast_CBE
48.55
33%
-85
- C1 -
3P19
1
?
D:
[17-197]
-------
K
L
V
V
I
T
G
A
S
S
G
I
G
E
A
I
A
R
R
-
F
S
E
E
G
H
P
--
L
L
L
L
A
R
R
V
E
R
L
K
A
L
NLPNTLCA
Q
V
D
V
T
D
K
Y
T
--------
F
D
-
T
A
I
T
R
A
E
K
I
Y
G
-
P
A
-----------
D
A
I
V
N
N
A
G
---
M
M
L
-
L
G
Q
I
D
-
T
Q
E
A
N
E
W
Q
R
M
F
D
V
N
V
L
G
L
L
N
G
M
Q
A
V
L
A
P
--
M
K
A
R
N
C
G
T
I
I
N
I
S
S
I
A
G
K
K
T
F
P
D
H
A
A
Y
C
G
T
K
F
A
V
H
A
I
S
E
N
V
R
E
E
V
A
A
S
N
V
R
V
M
T
I
A
P
S
----
A
V
-
K
T
----
E
L
L
-----------------------------------------------------------------------------------------------