@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo2346: (2016-04-02 )
MITIKNIQKSFGENKVLKGIDLTVKKGEVVTILGPSGSGKTTFLRCLNLLERPENGEISMHDQIINCKKPSKKEVLQLRKNTAMVFQQYNLFSHKTVIQNVMEGLTVARKIPKKIAHEIAERELTKVGLADKLSAYPSQLSGGQKQRVGIARALAINPDVILFDEPTAALDPELVGEVLEVMLEIARAGATMIVVTHEMEFAKRVADQVVFMDGGLIVEQGTPDEVFNHTKEERTKRFLHRVSADYLYEIKEVKKERVI
Atome Classification :
(43 SA)
-.........10--....---.--...20........30........40........50........60..-----------....--------..70-------.........-80.-.....--..90........100---..---...-----..110.....--...120--------........130.-..-.----...140.......150....-...160.......170..-.....180...-.-..-.190.......200.......210-.......220.......230.......240.......250.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-MI
T
I
K
N
I
Q
K
SF--GENK---V--LKG
I
D
L
T
V
KKG
E
V
V
T
I
LGPSGS
G
K
T
T
F
L
R
C
L
N
L
LERPENG
E
I
S
M
H
D
Q
-----------
I
INC--------KKP--------
S
K
K
E
V
L
Q
L
R
-
K
N
T
-
A
M
V
F
Q
--QYNLF
S
H
K
T
V
I
Q
N
V
M
---
E
G
---
L
T
V
-----
A
R
K
I
-
P
K
K
I
A
--
H
E
I
A
E
---------
R
E
L
T
KVG
L
A
D
K
L
-
S
A-
Y
----
P
S
QLSGGQK
Q
R
V
G
I
A
R
A
LAI-NP
D
V
I
L
FDEPTAAL
D
P
E
L
-
V
G
E
V
L
E
V
M
L
E
I
-
A
-RA-G
A
T
M
I
V
V
TH
E
M
E
F
A
K
R
V
A
D
Q
V
V
F
M-DG
G
L
I
V
EQGT
P
D
E
V
F
N
H
T
K
E
E
R
T
K
R
F
L
H
R
V
S
A
D
Y
L
Y
E
I
K
E
V
K
K
ERVI
12
PsiBlast_PDB
95.78
52%
-104
- C1 -
4U00
3
?
A:
[4-241]
-
I
I
R
I
R
N
L
H
K
W
F
--
G
P
L
H
---
V
--
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
L
-----------
S
V
K
--------------------
D
D
R
A
L
R
E
I
R
-
R
E
V
-
G
M
V
F
Q
--
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
T
---
L
A
---
P
M
R
-----
V
R
R
W
-
P
R
E
K
A
--
E
K
K
A
L
---------
E
L
L
E
R
V
G
I
L
D
Q
A
-
R
K
-
Y
----
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
-
V
G
E
V
L
D
V
M
R
D
L
-
A
-
Q
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
-
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
Q
R
V
-----------------
22
PsiBlast_CBE
94.85
54%
-113
- C1 -
4YMU
2
?
A:
[1-239]
-
M
I
F
V
N
D
V
Y
K
N
F
--
G
S
L
E
---
V
--
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
-----------
K
I
N
N
-------------------
G
K
V
N
I
N
K
V
R
-
Q
K
V
-
G
M
V
F
Q
--
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
---
L
A
---
P
V
K
-----
V
K
K
M
-
N
K
K
E
A
--
E
E
L
A
V
---------
D
L
L
A
K
V
G
L
L
D
K
K
-
D
Q
-
Y
----
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
-
V
K
E
V
L
N
V
M
K
Q
L
-
A
-
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
-
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
-----------------
35
PsiBlast_CBE
94.70
52%
-104
- C1 -
4U02
1
?
B:
[4-241]
-
I
I
R
I
R
N
L
H
K
W
F
--
G
P
L
H
---
V
--
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
L
-----------
S
V
K
--------------------
D
D
R
A
L
R
E
I
R
-
R
E
V
-
G
M
V
F
Q
--
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
T
---
L
A
---
P
M
R
-----
V
R
R
W
-
P
R
E
K
A
--
E
K
K
A
L
---------
E
L
L
E
R
V
G
I
L
D
Q
A
-
R
K
-
Y
----
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
-
V
G
E
V
L
D
V
M
R
D
L
-
A
-
Q
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
-
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
Q
R
V
-----------------
13
PsiBlast_PDB
94.38
52%
-104
- C1 -
4U02
1
?
A:
[4-241]
-
I
I
R
I
R
N
L
H
K
W
F
--
G
P
L
H
---
V
--
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
L
-----------
S
V
K
--------------------
D
D
R
A
L
R
E
I
R
-
R
E
V
-
G
M
V
F
Q
--
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
T
---
L
A
---
P
M
R
-----
V
R
R
W
-
P
R
E
K
A
--
E
K
K
A
L
---------
E
L
L
E
R
V
G
I
L
D
Q
A
-
R
K
-
Y
----
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
-
V
G
E
V
L
D
V
M
R
D
L
-
A
-
Q
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
-
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
Q
R
V
-----------------
21
PsiBlast_CBE
93.95
54%
-110
- C1 -
4YMV
1
?
A:
[1-239]
-
M
I
F
V
N
D
V
Y
K
N
F
--
G
S
L
E
---
V
--
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
-----------
K
I
N
N
-------------------
G
K
V
N
I
N
K
V
R
-
Q
K
V
-
G
M
V
F
Q
--
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
---
L
A
---
P
V
K
-----
V
K
K
M
-
N
K
K
E
A
--
E
E
L
A
V
---------
D
L
L
A
K
V
G
L
L
D
K
K
-
D
Q
-
Y
----
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
-
V
K
E
V
L
N
V
M
K
Q
L
-
A
-
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
-
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
-----------------
34
PsiBlast_CBE
93.90
52%
-106
- C1 -
4U02
1
?
C:
[4-241]
-
I
I
R
I
R
N
L
H
K
W
F
--
G
P
L
H
---
V
--
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
L
-----------
S
V
K
--------------------
D
D
R
A
L
R
E
I
R
-
R
E
V
-
G
M
V
F
Q
--
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
T
---
L
A
---
P
M
R
-----
V
R
R
W
-
P
R
E
K
A
--
E
K
K
A
L
---------
E
L
L
E
R
V
G
I
L
D
Q
A
-
R
K
-
Y
----
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
-
V
G
E
V
L
D
V
M
R
D
L
-
A
-
Q
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
-
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
Q
R
V
-----------------
117
HHSearch
93.67
49%
-108
- C1 -
1B0U
4
HISP_SALTY
A:
[7-255]
--
L
H
V
I
D
L
H
K
R
Y
--
G
G
H
E
---
V
--
L
K
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
E
K
P
S
E
G
A
I
I
V
N
G
Q
-----------
N
I
N
L
--------
V
R
D
KDGQLKVA
D
K
N
Q
L
R
L
L
R
-
T
R
L
-
T
M
V
F
Q
--
H
F
N
L
W
S
H
M
T
V
L
E
N
V
M
---
E
A
---
P
I
Q
-----
V
L
G
L
-
S
K
H
D
A
--
R
E
R
A
L
---------
K
Y
L
A
K
V
G
I
D
E
R
A
Q
G
K
-
Y
----
P
V
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
-
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
-
V
G
E
V
L
R
I
M
Q
Q
L
-
A
-
E
E
-
G
K
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
-
H
Q
G
K
I
E
E
E
G
D
P
E
Q
V
F
G
N
P
Q
S
P
R
L
Q
Q
F
L
K
G
------------------
4
PsiBlast_PDB
93.67
54%
-110
- C1 -
4YMV
1
?
J:
[1-239]
-
M
I
F
V
N
D
V
Y
K
N
F
--
G
S
L
E
---
V
--
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
-----------
K
I
N
N
-------------------
G
K
V
N
I
N
K
V
R
-
Q
K
V
-
G
M
V
F
Q
--
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
---
L
A
---
P
V
K
-----
V
K
K
M
-
N
K
K
E
A
--
E
E
L
A
V
---------
D
L
L
A
K
V
G
L
L
D
K
K
-
D
Q
-
Y
----
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
-
V
K
E
V
L
N
V
M
K
Q
L
-
A
-
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
-
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
-----------------
2
PsiBlast_PDB
93.36
54%
-109
- C1 -
4YMT
-
?
J:
[1-239]
-
M
I
F
V
N
D
V
Y
K
N
F
--
G
S
L
E
---
V
--
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
-----------
K
I
N
N
-------------------
G
K
V
N
I
N
K
V
R
-
Q
K
V
-
G
M
V
F
Q
--
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
---
L
A
---
P
V
K
-----
V
K
K
M
-
N
K
K
E
A
--
E
E
L
A
V
---------
D
L
L
A
K
V
G
L
L
D
K
K
-
D
Q
-
Y
----
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
-
V
K
E
V
L
N
V
M
K
Q
L
-
A
-
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
-
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
-----------------
1
PsiBlast_PDB
93.33
54%
-110
- C1 -
4YMS
-
?
J:
[1-239]
-
M
I
F
V
N
D
V
Y
K
N
F
--
G
S
L
E
---
V
--
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
-----------
K
I
N
N
-------------------
G
K
V
N
I
N
K
V
R
-
Q
K
V
-
G
M
V
F
Q
--
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
---
L
A
---
P
V
K
-----
V
K
K
M
-
N
K
K
E
A
--
E
E
L
A
V
---------
D
L
L
A
K
V
G
L
L
D
K
K
-
D
Q
-
Y
----
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
-
V
K
E
V
L
N
V
M
K
Q
L
-
A
-
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
-
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
-----------------
3
PsiBlast_PDB
93.21
54%
-111
- C1 -
4YMU
2
?
J:
[1-239]
-
M
I
F
V
N
D
V
Y
K
N
F
--
G
S
L
E
---
V
--
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
-----------
K
I
N
N
-------------------
G
K
V
N
I
N
K
V
R
-
Q
K
V
-
G
M
V
F
Q
--
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
---
L
A
---
P
V
K
-----
V
K
K
M
-
N
K
K
E
A
--
E
E
L
A
V
---------
D
L
L
A
K
V
G
L
L
D
K
K
-
D
Q
-
Y
----
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
-
V
K
E
V
L
N
V
M
K
Q
L
-
A
-
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
-
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
-----------------
9
PsiBlast_PDB
93.09
53%
-107
- C1 -
2OUK
1
?
A:
[24-262]
-
M
I
D
V
H
Q
L
K
K
S
F
--
G
S
L
E
---
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
-----------
N
L
K
A
--------
K
D
T
--------
N
L
N
K
V
---
R
-
E
E
V
-
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
---
L
A
---
P
M
K
-----
V
R
K
W
-
P
R
E
K
A
--
E
A
K
A
M
---------
E
L
L
D
K
V
G
L
K
D
K
A
-
H
A
-
Y
----
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
-
V
G
E
V
L
S
V
M
K
Q
L
-
A
-
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
-
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
-----------------
33
PsiBlast_CBE
93.06
52%
-102
- C1 -
4U02
1
?
D:
[4-241]
-
I
I
R
I
R
N
L
H
K
W
F
--
G
P
L
H
---
V
--
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
Q
E
G
E
V
V
V
D
G
L
-----------
S
V
K
--------------------
D
D
R
A
L
R
E
I
R
-
R
E
V
-
G
M
V
F
Q
--
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
T
---
L
A
---
P
M
R
-----
V
R
R
W
-
P
R
E
K
A
--
E
K
K
A
L
---------
E
L
L
E
R
V
G
I
L
D
Q
A
-
R
K
-
Y
----
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
-
V
G
E
V
L
D
V
M
R
D
L
-
A
-
Q
G
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
-
D
G
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
E
E
R
T
R
S
F
L
Q
R
V
-----------------
30
PsiBlast_CBE
92.34
53%
-104
- C1 -
2OLK
1
?
C:
[24-262]
-
M
I
D
V
H
Q
L
K
K
S
F
--
G
S
L
E
---
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
-----------
N
L
K
A
--------
K
D
T
--------
N
L
N
K
V
---
R
-
E
E
V
-
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
---
L
A
---
P
M
K
-----
V
R
K
W
-
P
R
E
K
A
--
E
A
K
A
M
---------
E
L
L
D
K
V
G
L
K
D
K
A
-
H
A
-
Y
----
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
-
V
G
E
V
L
S
V
M
K
Q
L
-
A
-
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
-
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
-----------------
24
PsiBlast_CBE
92.34
53%
-109
- C1 -
3C4J
4
?
B:
[24-262]
-
M
I
D
V
H
Q
L
K
K
S
F
--
G
S
L
E
---
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
-----------
N
L
K
A
--------
K
D
T
--------
N
L
N
K
V
---
R
-
E
E
V
-
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
---
L
A
---
P
M
K
-----
V
R
K
W
-
P
R
E
K
A
--
E
A
K
A
M
---------
E
L
L
D
K
V
G
L
K
D
K
A
-
H
A
-
Y
----
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
-
V
G
E
V
L
S
V
M
K
Q
L
-
A
-
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
-
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
-----------------
27
PsiBlast_CBE
92.14
53%
-103
- C1 -
2OUK
1
?
C:
[24-262]
-
M
I
D
V
H
Q
L
K
K
S
F
--
G
S
L
E
---
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
-----------
N
L
K
A
--------
K
D
T
--------
N
L
N
K
V
---
R
-
E
E
V
-
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
---
L
A
---
P
M
K
-----
V
R
K
W
-
P
R
E
K
A
--
E
A
K
A
M
---------
E
L
L
D
K
V
G
L
K
D
K
A
-
H
A
-
Y
----
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
-
V
G
E
V
L
S
V
M
K
Q
L
-
A
-
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
-
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
-----------------
5
PsiBlast_PDB
92.10
54%
-109
- C1 -
4YMW
-
?
J:
[1-239]
-
M
I
F
V
N
D
V
Y
K
N
F
--
G
S
L
E
---
V
--
L
K
G
V
T
L
K
V
N
K
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
E
E
P
T
K
G
E
V
F
I
D
G
V
-----------
K
I
N
N
-------------------
G
K
V
N
I
N
K
V
R
-
Q
K
V
-
G
M
V
F
Q
--
H
F
N
L
F
P
H
L
T
A
I
E
N
I
T
---
L
A
---
P
V
K
-----
V
K
K
M
-
N
K
K
E
A
--
E
E
L
A
V
---------
D
L
L
A
K
V
G
L
L
D
K
K
-
D
Q
-
Y
----
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
-
V
K
E
V
L
N
V
M
K
Q
L
-
A
-
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
-
D
D
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
N
E
R
T
R
E
F
L
S
K
I
-----------------
31
PsiBlast_CBE
91.46
53%
-104
- C1 -
2OLK
2
?
B:
[24-262]
-
M
I
D
V
H
Q
L
K
K
S
F
--
G
S
L
E
---
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
-----------
N
L
K
A
--------
K
D
T
--------
N
L
N
K
V
---
R
-
E
E
V
-
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
---
L
A
---
P
M
K
-----
V
R
K
W
-
P
R
E
K
A
--
E
A
K
A
M
---------
E
L
L
D
K
V
G
L
K
D
K
A
-
H
A
-
Y
----
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
-
V
G
E
V
L
S
V
M
K
Q
L
-
A
-
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
-
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
-----------------
29
PsiBlast_CBE
91.14
53%
-102
- C1 -
2OLK
1
?
D:
[24-262]
-
M
I
D
V
H
Q
L
K
K
S
F
--
G
S
L
E
---
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
-----------
N
L
K
A
--------
K
D
T
--------
N
L
N
K
V
---
R
-
E
E
V
-
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
---
L
A
---
P
M
K
-----
V
R
K
W
-
P
R
E
K
A
--
E
A
K
A
M
---------
E
L
L
D
K
V
G
L
K
D
K
A
-
H
A
-
Y
----
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
-
V
G
E
V
L
S
V
M
K
Q
L
-
A
-
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
-
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
-----------------
14
PsiBlast_PDB
91.12
47%
-106
- C1 -
1B0U
4
HISP_SALTY
A:
[7-253]
--
L
H
V
I
D
L
H
K
R
Y
--
G
G
H
E
---
V
--
L
K
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
E
K
P
S
E
G
A
I
I
V
N
G
Q
-----------
N
I
N
L
V
R
D
KDGQL
K
V
A
--------
D
K
N
Q
L
R
L
L
R
-
T
R
L
-
T
M
V
F
Q
--
H
F
N
L
W
S
H
M
T
V
L
E
N
V
M
---
E
A
---
P
I
Q
-----
V
L
G
L
-
S
K
H
D
A
--
R
E
R
A
L
---------
K
Y
L
A
K
V
G
I
D
E
R
A
-
Q
G
K
Y
----
P
V
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
-
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
-
V
G
E
V
L
R
I
M
Q
Q
L
-
A
-
E
E
-
G
K
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
-
H
Q
G
K
I
E
E
E
G
D
P
E
Q
V
F
G
N
P
Q
S
P
R
L
Q
Q
F
L
--------------------
7
PsiBlast_PDB
91.10
53%
-109
- C1 -
2OLJ
4
?
A:
[24-262]
-
M
I
D
V
H
Q
L
K
K
S
F
--
G
S
L
E
---
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
-----------
N
L
K
A
--------
K
D
T
--------
N
L
N
K
V
---
R
-
E
E
V
-
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
---
L
A
---
P
M
K
-----
V
R
K
W
-
P
R
E
K
A
--
E
A
K
A
M
---------
E
L
L
D
K
V
G
L
K
D
K
A
-
H
A
-
Y
----
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
-
V
G
E
V
L
S
V
M
K
Q
L
-
A
-
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
-
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
-----------------
8
PsiBlast_PDB
90.88
53%
-102
- C1 -
2OLK
1
?
A:
[24-262]
-
M
I
D
V
H
Q
L
K
K
S
F
--
G
S
L
E
---
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
-----------
N
L
K
A
--------
K
D
T
--------
N
L
N
K
V
---
R
-
E
E
V
-
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
---
L
A
---
P
M
K
-----
V
R
K
W
-
P
R
E
K
A
--
E
A
K
A
M
---------
E
L
L
D
K
V
G
L
K
D
K
A
-
H
A
-
Y
----
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
-
V
G
E
V
L
S
V
M
K
Q
L
-
A
-
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
-
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
-----------------
23
PsiBlast_CBE
90.72
53%
-108
- C1 -
3C41
3
?
K:
[3-241]
-
M
I
D
V
H
Q
L
K
K
S
F
--
G
S
L
E
---
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
-----------
N
L
K
A
--------
K
D
T
--------
N
L
N
K
V
---
R
-
E
E
V
-
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
---
L
A
---
P
M
K
-----
V
R
K
W
-
P
R
E
K
A
--
E
A
K
A
M
---------
E
L
L
D
K
V
G
L
K
D
K
A
-
H
A
-
Y
----
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
-
V
G
E
V
L
S
V
M
K
Q
L
-
A
-
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
-
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
-----------------
6
PsiBlast_PDB
90.67
53%
-101
- C1 -
3C41
3
?
J:
[3-241]
-
M
I
D
V
H
Q
L
K
K
S
F
--
G
S
L
E
---
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
-----------
N
L
K
A
--------
K
D
T
--------
N
L
N
K
V
---
R
-
E
E
V
-
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
---
L
A
---
P
M
K
-----
V
R
K
W
-
P
R
E
K
A
--
E
A
K
A
M
---------
E
L
L
D
K
V
G
L
K
D
K
A
-
H
A
-
Y
----
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
-
V
G
E
V
L
S
V
M
K
Q
L
-
A
-
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
-
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
-----------------
11
PsiBlast_PDB
89.65
53%
-102
- C1 -
3C4J
3
?
A:
[24-262]
-
M
I
D
V
H
Q
L
K
K
S
F
--
G
S
L
E
---
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
-----------
N
L
K
A
--------
K
D
T
--------
N
L
N
K
V
---
R
-
E
E
V
-
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
---
L
A
---
P
M
K
-----
V
R
K
W
-
P
R
E
K
A
--
E
A
K
A
M
---------
E
L
L
D
K
V
G
L
K
D
K
A
-
H
A
-
Y
----
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
-
V
G
E
V
L
S
V
M
K
Q
L
-
A
-
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
-
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
-----------------
32
PsiBlast_CBE
89.33
53%
-102
- C1 -
2OLJ
3
?
B:
[24-262]
-
M
I
D
V
H
Q
L
K
K
S
F
--
G
S
L
E
---
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
-----------
N
L
K
A
--------
K
D
T
--------
N
L
N
K
V
---
R
-
E
E
V
-
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
---
L
A
---
P
M
K
-----
V
R
K
W
-
P
R
E
K
A
--
E
A
K
A
M
---------
E
L
L
D
K
V
G
L
K
D
K
A
-
H
A
-
Y
----
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
-
V
G
E
V
L
S
V
M
K
Q
L
-
A
-
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
-
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
-----------------
25
PsiBlast_CBE
89.01
53%
-106
- C1 -
2Q0H
4
?
B:
[24-262]
-
M
I
D
V
H
Q
L
K
K
S
F
--
G
S
L
E
---
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
-----------
N
L
K
A
--------
K
D
T
--------
N
L
N
K
V
---
R
-
E
E
V
-
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
---
L
A
---
P
M
K
-----
V
R
K
W
-
P
R
E
K
A
--
E
A
K
A
M
---------
E
L
L
D
K
V
G
L
K
D
K
A
-
H
A
-
Y
----
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
-
V
G
E
V
L
S
V
M
K
Q
L
-
A
-
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
-
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
-----------------
10
PsiBlast_PDB
88.88
53%
-102
- C1 -
2Q0H
4
?
A:
[24-262]
-
M
I
D
V
H
Q
L
K
K
S
F
--
G
S
L
E
---
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
-----------
N
L
K
A
--------
K
D
T
--------
N
L
N
K
V
---
R
-
E
E
V
-
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
---
L
A
---
P
M
K
-----
V
R
K
W
-
P
R
E
K
A
--
E
A
K
A
M
---------
E
L
L
D
K
V
G
L
K
D
K
A
-
H
A
-
Y
----
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
-
V
G
E
V
L
S
V
M
K
Q
L
-
A
-
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
-
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
T
K
A
F
L
S
K
V
-----------------
113
HHSearch
86.35
53%
-108
- C1 -
2OLJ
4
?
A:
[24-254]
-
M
I
D
V
H
Q
L
K
K
S
F
--
G
S
L
E
---
V
--
L
K
G
I
N
V
H
I
R
E
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
E
D
F
D
E
G
E
I
I
I
D
G
I
-----------
N
L
K
A
--------
K
-----------
D
T
N
L
N
K
V
R
-
E
E
V
-
G
M
V
F
Q
--
R
F
N
L
F
P
H
M
T
V
L
N
N
I
T
---
L
A
---
P
M
K
-----
V
R
K
W
-
P
R
E
K
A
--
E
A
K
A
M
---------
E
L
L
D
K
V
G
L
K
D
K
A
-
H
A
-
Y
----
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
-
V
G
E
V
L
S
V
M
K
Q
L
-
A
-
N
E
-
G
M
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
-
D
G
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
H
E
R
-------------------------
130
Fugue
79.85
44%
-113
- C1 -
1B0U
4
HISP_SALTY
A:
[5-261]
N
K
L
H
V
I
D
L
H
K
R
Y
--
G
G
--HEV
L
--
K
-
G
V
S
L
Q
A
R
A
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
E
K
P
S
E
G
A
I
I
V
N
G
-QNI
N
L
V
R
D
KDG
Q
L
K
V
--------
A
D
K
--------
N
Q
L
R
L
L
R
T
--
R
-
L
-
T
M
V
F
Q
--
H
F
N
L
W
S
H
M
T
V
L
E
N
V
M
---
E
A
---
P
I
Q
VLGLS
K
H
D
A
-
R
E
R
A
L
--
K
Y
L
A
K
V
GIDERAQG--------------
K
-
Y
----
P
V
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
E-
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
-
V
G
E
V
L
R
I
M
Q
Q
L
-
A
-
E
E
-
G
K
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
H
-
Q
G
K
I
E
E
E
G
D
P
E
Q
V
F
G
N
P
-
Q
S
------
P
R
L
Q
Q
F
L
K
G
S
L
K
K
L
E
-----
89
PsiBlast_CBE
70.46
36%
-99
- C1 -
3FVQ
3
FBPC_NEIG1
B:
[5-239]
--
L
H
I
G
H
L
S
K
S
F
--
Q
N
T
P
---
V
--
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
K
-----------
T
I
F
--------------------
S
K
N
T
N
L
P
V
R
E
R
R
L
-
G
Y
L
V
Q
--
E
G
V
L
F
P
H
L
T
V
Y
R
N
I
A
---
Y
G
---
L
G
N
-----
G
K
G
R
-
T
A
Q
E
R
--
Q
R
I
-
E
---------
A
M
L
E
L
T
G
I
S
E
L
A
-
G
R
-
Y
----
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
-
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
-
R
R
Q
I
R
E
D
M
I
A
A
-
L
-
R
A
N
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
-
K
Q
G
R
I
L
Q
T
A
S
P
H
E
L
Y
R
Q
P
A
D
L
D
A
A
L
F
I
--------------------
90
PsiBlast_CBE
68.94
36%
-98
- C1 -
3FVQ
3
FBPC_NEIG1
A:
[5-244]
--
L
H
I
G
H
L
S
K
S
F
--
Q
N
T
P
---
V
--
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
K
-----------
T
I
F
--------------------
S
K
N
T
N
L
P
V
R
E
R
R
L
-
G
Y
L
V
Q
--
E
G
V
L
F
P
H
L
T
V
Y
R
N
I
A
---
Y
G
---
L
G
N
-----
G
K
G
R
-
T
A
Q
E
R
--
Q
R
I
-
E
---------
A
M
L
E
L
T
G
I
S
E
L
A
-
G
R
-
Y
----
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
-
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
-
R
R
Q
I
R
E
D
M
I
A
A
-
L
-
R
A
N
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
-
K
Q
G
R
I
L
Q
T
A
S
P
H
E
L
Y
R
Q
P
A
D
L
D
A
A
L
F
I
--------------------
108
HHSearch
65.63
35%
-91
- C1 -
3FVQ
3
FBPC_NEIG1
A:
[4-237]
-
A
L
H
I
G
H
L
S
K
S
F
--
Q
N
T
P
---
V
--
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
K
-----------
T
I
F
S
--------
K
-----------
N
T
N
L
P
V
R
E
-
R
R
L
-
G
Y
L
V
Q
--
E
G
V
L
F
P
H
L
T
V
Y
R
N
I
A
---
Y
G
---
L
G
N
-----
G
K
G
--
R
T
A
Q
E
--
R
Q
R
I
E
---------
A
M
L
E
L
T
G
I
S
E
L
A
-
G
R
-
Y
----
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
-
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
-
R
R
Q
I
R
E
D
M
I
A
A
-
L
R
A
N
-
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
-
K
Q
G
R
I
L
Q
T
A
S
P
H
E
L
Y
R
Q
P
A
D
---------------------------
46
PsiBlast_CBE
64.62
35%
-99
- C1 -
1VCI
1
?
A:
[13-237]
--
V
K
L
E
N
L
T
K
R
F
--
G
N
F
T
---
A
--
V
N
K
L
N
L
T
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
E
G
R
I
Y
F
G
D
R
-----------
D
V
T
Y
--------
L
P
P
--------
K
D
R
--------
N
I
-
S
M
V
F
Q
--------
H
M
T
V
Y
E
N
I
A
---
F
P
---
L
--------
K
K
F
-
P
K
D
E
I
--
D
K
R
V
R
---------
W
A
A
E
L
L
Q
I
E
E
L
L
-
N
R
-
Y
----
P
A
Q
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
-
E
P
D
V
L
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
A
M
R
A
E
I
K
K
L
Q
-
Q
-
K
L
-
K
V
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
-
N
R
G
Q
L
L
Q
I
G
S
P
T
E
V
Y
--------------------------------
92
PsiBlast_CBE
63.09
39%
-99
- C1 -
4MKI
4
ECFA2_CALS4
B:
[27-236]
------------------------
L
K
D
I
N
F
S
I
D
D
E
E
F
V
G
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
G
L
L
K
P
S
K
G
K
I
Y
I
N
G
I
-----------
D
I
T
D
--------
K
K
V
--------
S
L
K
D
I
---
R
-
K
Q
V
-
G
L
V
F
Q
YP
E
Y
Q
L
F
-
E
E
T
V
F
K
D
I
A
---
F
G
P
S
N
L
G
L
-----
S
E
E
E
-
V
K
E
R
V
--
Y
E
A
M
E
---------
I
V
G
I
S
K
E
L
A
D
K
-----
S
----
P
F
E
L
S
G
G
Q
K
R
R
V
A
I
A
G
I
L
A
M
-
R
P
K
I
L
I
L
D
E
P
T
A
G
L
D
P
K
G
-
K
Q
E
I
L
N
K
I
K
E
I
H
D
-
K
Y
-
K
M
I
T
I
L
V
S
H
N
M
E
D
I
A
R
I
A
D
K
I
I
V
M
-
N
R
G
K
I
E
L
I
G
T
P
R
E
V
F
--------------------------------
78
PsiBlast_CBE
62.76
35%
-106
- C1 -
3TIF
7
Y796_METJA
A:
[1-221]
-
M
V
K
L
K
N
V
T
K
T
Y
K
M
G
E
E
I
---
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
-------------
I
K
T
--------
N
D
L
--------
D
D
D
E
L
T
K
I
R
-
R
D
K
I
G
F
V
F
Q
--
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
---
L
P
---
L
I
F
-----
K
Y
R
G
-
A
M
S
-
G
--
E
E
R
R
K
---------
R
A
L
E
C
L
K
M
A
E
L
E
-
E
R
-
F
ANHK
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
-
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
-
G
E
K
I
M
Q
L
L
K
K
L
-
N
-
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
-
R
F
G
E
R
I
I
Y
L
-
K
D
G
--------------------------------------------
76
PsiBlast_CBE
61.95
35%
-107
- C1 -
1L2T
4
Y796_METJA
A:
[1-221]
-
M
I
K
L
K
N
V
T
K
T
Y
K
M
G
E
E
I
---
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
-------------
I
K
T
--------
N
D
L
--------
D
D
D
E
L
T
K
I
R
-
R
D
K
I
G
F
V
F
Q
--
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
---
L
P
---
L
I
F
-----
K
Y
R
G
-
A
M
S
-
G
--
E
E
R
R
K
---------
R
A
L
E
C
L
K
M
A
E
L
E
-
E
R
-
F
ANHK
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
-
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
-
G
E
K
I
M
Q
L
L
K
K
L
-
N
-
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
-
R
F
G
E
R
I
I
Y
L
-
K
D
G
--------------------------------------------
97
PsiBlast_CBE
61.57
32%
-87
- C1 -
2FGK
2
D:
[8-247]
--
I
T
F
R
N
I
R
F
R
Y
--
K
P
D
S
PV-
I
--
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
-----------
D
L
A
L
--------
A
D
P
--------
N
-----
W
L
R
-
R
Q
V
-
G
V
V
L
Q
--
D
-
N
V
L
L
N
R
S
I
I
D
N
I
S
LAN
P
G
---
M
S
V
-----
E
K
V
I
Y
A
A
K
L
A
GA
H
D
F
I
S
----------
E
L
R
E
-
G
Y
N
T
I
V
-
G
E
-
Q
----
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
-
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
-
E
H
V
I
M
R
N
M
H
K
I
-
C
-
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
-
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
--
S
E
P
E
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
--------------
77
PsiBlast_CBE
61.56
35%
-108
- C1 -
3TIF
7
Y796_METJA
B:
[1-221]
-
M
V
K
L
K
N
V
T
K
T
Y
KM
G
E
E
I
---
I
YA
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
-------------
I
K
T
--------
N
D
L
--------
D
D
D
E
L
T
K
I
R
-
R
D
K
I
G
F
V
F
Q
--
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
---
L
P
---
L
I
F
-----
K
Y
R
G
-
A
M
S
-
G
--
E
E
R
R
K
---------
R
A
L
E
C
L
K
M
A
E
L
E
-
E
R
-
F
ANHK
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
-
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
-
G
E
K
I
M
Q
L
L
K
K
L
-
N
-
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
-
R
F
G
E
R
I
I
Y
L
-
K
D
G
--------------------------------------------
99
PsiBlast_CBE
60.79
32%
-87
- C1 -
2FGK
2
HLYBP_ECOLX
B:
[8-247]
--
I
T
F
R
N
I
R
F
R
Y
--
K
P
D
S
PV-
I
--
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
-----------
D
L
A
L
--------
A
D
P
--------
N
-----
W
L
R
-
R
Q
V
-
G
V
V
L
Q
--
D
-
N
V
L
L
N
R
S
I
I
D
N
I
S
LAN
P
G
---
M
S
V
-----
E
K
V
I
Y
A
A
K
L
A
GA
H
D
F
I
S
----------
E
L
R
E
-
G
Y
N
T
I
V
-
G
E
-
Q
----
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
-
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
-
E
H
V
I
M
R
N
M
H
K
I
-
C
-
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
-
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
--
S
E
P
E
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
--------------
75
PsiBlast_CBE
60.77
35%
-107
- C1 -
1L2T
4
Y796_METJA
B:
[1-221]
-
M
I
K
L
K
N
V
T
K
T
Y
KM
G
E
E
I
---
I
YA
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
T
E
G
E
V
Y
I
D
N
-------------
I
K
T
--------
N
D
L
--------
D
D
D
E
L
T
K
I
R
-
R
D
K
I
G
F
V
F
Q
--
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
---
L
P
---
L
I
F
-----
K
Y
R
G
-
A
M
S
-
G
--
E
E
R
R
K
---------
R
A
L
E
C
L
K
M
A
E
L
E
-
E
R
-
F
ANHK
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
-
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
-
G
E
K
I
M
Q
L
L
K
K
L
-
N
-
E
E
D
G
K
T
V
V
V
V
T
H
D
I
N
V
A
-
R
F
G
E
R
I
I
Y
L
-
K
D
G
--------------------------------------------
100
PsiBlast_CBE
58.67
32%
-83
- C1 -
2FGK
2
HLYBP_ECOLX
A:
[8-247]
--
I
T
F
R
N
I
R
F
R
Y
--
K
P
D
S
PV-
I
--
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
-----------
D
L
A
L
--------
A
D
P
--------
N
-----
W
L
R
-
R
Q
V
-
G
V
V
L
Q
--
D
-
N
V
L
L
N
R
S
I
I
D
N
I
S
LAN
P
G
---
M
S
V
-----
E
K
V
I
Y
A
A
K
L
A
GA
H
D
F
I
S
----------
E
L
R
E
-
G
Y
N
T
I
V
-
G
E
-
Q
----
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
-
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
-
E
H
V
I
M
R
N
M
H
K
I
-
C
-
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
-
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
--
S
E
P
E
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
--------------
98
PsiBlast_CBE
57.36
32%
-85
- C1 -
2FGK
2
HLYBP_ECOLX
C:
[8-247]
--
I
T
F
R
N
I
R
F
R
Y
--
K
P
D
S
PV-
I
--
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
H
-----------
D
L
A
L
--------
A
D
P
--------
N
-----
W
L
R
-
R
Q
V
-
G
V
V
L
Q
--
D
-
N
V
L
L
N
R
S
I
I
D
N
I
S
LAN
P
G
---
M
S
V
-----
E
K
V
I
Y
A
A
K
L
A
GA
H
D
F
I
S
----------
E
L
R
E
-
G
Y
N
T
I
V
-
G
E
-
Q
----
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
-
N
P
K
I
L
I
F
D
Q
A
T
S
A
L
D
Y
E
S
-
E
H
V
I
M
R
N
M
H
K
I
-
C
-
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
-
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
--
S
E
P
E
S
L
Y
S
Y
L
Y
Q
L
Q
S
D
--------------