@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Lmo2496: (2016-04-04 )
MLTKKPEINTILQVTPDPHSLPAAMATEDLHVYYGDNHAIKGVDLTFPENKVTALIGPSGCGKSTYLRALNRMNDEIDGCRMEGQILYDGININRKEVDLYNVRKEIGMVFQKPNPFTKSIYENVAFGLKRHGMKNKKEIMERVEKSLRRAALWDEVKDDLGKSALSLSGGQQQRLCIARAVAMQPKVLLLDEPASALDPISTSKIEDLINELKNKYTIIIVTHNMQQAARVSDYTSFFYLGEVVEFSGTSELFTNPQEKQTEDYISGNFG
Atome Classification :
(45 SA)
.........10........20........30.......-.--40........--50........60........70..----......80---........90------------.....--------..-----------..---100....-...110...--...-.-120...------....--130..-.....140.....----..150--......-------..-------160.......170.......180..-.....190.......200.......210.--.-..--.--..220.......230.......240........250......--.260.......270--------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MLTKKPEI
N
T
I
L
Q
VTPDPHSLP
A
A
MAT
E
D
L
H
V
Y
YGDN
H
-
A
--IK
G
V
D
L
TFPE--N
K
V
T
A
L
IGPSGC
G
K
S
T
Y
L
R
A
L
N
R
M----NDEIDGCR---ME
G
Q
I
L
Y
DG-------------INI
N
R
--------
K
E
-----------
V
D
---
L
Y
N
V
R
K
E
-
I
G
M
VFQKPN--
P
F
T
-
K
-
S
I
Y
E
N
V
------
A
F
G
L
--
K
RHGM-K
N
K
K
E
I
M
E
R
V
E
K
S
----
L
R
R
A
---
A
L
W
D
E
V
-------
K
D
-------
D
L
G
K
S
A
LSLSGG
Q
Q
Q
R
L
C
I
A
R
A
VAM-Q
P
K
V
L
L
LDEPASALDPI
S
T
S
K
I
E
D
L
I
N
E
L
--K-N
K
--
Y
--
T
I
I
I
V
TH
N
M
Q
Q
A
A
R
VS
D
Y
T
S
F
F
Y
L
-
G
E
V
VEFSG
T
S
E
LFTNP
Q
--
E
K
Q
T
E
D
YISGNFG---------------------------------------------------------------------------------------------
119
HHSearch
94.06
37%
-82
- C1 -
1B0U
4
HISP_SALTY
A:
[5-256]
----------------------
N
K
L
H
V
I
D
L
H
K
R
Y
G
G
H
E
-
V
--
L
K
G
V
S
L
Q
A
R
A
--
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
----
E
K
P
--------
S
E
G
A
I
I
V
N
G
-------------
Q
N
I
N
L
--------
V
R
D
KDGQLKVAD
K
N
Q
---
L
R
L
L
R
T
R
-
L
T
M
V
F
Q
H
F
N
--
L
W
S
H
M
-
T
V
L
E
N
V
------
M
E
A
P
--
I
Q
V
L
G
-
L
S
K
H
D
A
R
E
R
A
L
K
Y
----
L
A
K
V
---
G
I
D
E
R
A
-----------------
Q
G
K
Y
P
V
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
-
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
L
R
I
M
Q
Q
L
--
A
E
E
G
--
K
--
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
H
Q
-
G
K
I
E
E
E
G
D
P
E
Q
V
F
G
N
P
Q
--
S
P
R
L
Q
Q
F
L
K
G
S
-----------------------------------------------------------------------------------------------
92
Fugue
90.39
33%
-78
- C1 -
3TUZ
3
METN_ECOLI
H:
[23-362]
---------
H
M
I
K
L
S
N
---------
I
T
K
V
F
H
Q
G
T
R
T
I
Q
-
A
--
L
N
N
V
S
L
H
V
P
A
--
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
-
L
----
L
E
R
P
T
-------
E
G
S
V
L
V
D
G
-------------
Q
E
L
T
T
L-------
S
E
-----------
S
E
---
L
T
K
A
R
R
Q
-
I
G
M
I
F
Q
H
F
N
L-
L
S
S
-
R
-
T
V
F
G
N
V
------
A
L
P
L
--
E
L
D
N
T
-
P
K
-
D
E
V
K
R
R
V
T
E
L
----
L
S
L
V
---
G
L
-----------
G
D
-------
K
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
-
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
--
N
-
R
R
--
L
GL
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
-
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
--
T
P
L
A
Q
K
F
I
Q
S
T
L
H
LDIPEDYQERLQAEPFTDCVPMLRLEFTGQSVDAPLLSETARRFNVNNNIISAQMDYAGGVKFGIMLTEMHGTQQDTQAAIAWLQEHHVKVEV
16
PsiBlast_PDB
86.64
33%
-74
- C1 -
3TUZ
1
METN_ECOLI
C:
[23-268]
------------------
H
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
-
A
--
L
N
N
V
S
L
H
V
P
A
--
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
----
E
R
P
--------
T
E
G
S
V
L
V
D
G
-------------
Q
E
L
T
T
L-------
S
E
-----------
S
E
---
L
T
K
A
R
R
Q
-
I
G
M
I
F
Q
H
F
N
--
L
L
S
S
R
-
T
V
F
G
N
V
------
A
L
P
L
--
E
L
D
N
T
-
P
-
K
D
E
V
K
R
R
V
T
E
L
----
L
S
L
V
---
G
L
G
D
---------
K
H
-------
D
S
Y
P
S
--
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
-
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
--
N
-
R
R
LG
L
--
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
-
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
--
T
P
L
A
Q
K
F
I
Q
S
T
L
----------------------------------------------------------------------------------------------
37
PsiBlast_CBE
85.43
33%
-71
- C1 -
3TUZ
1
METN_ECOLI
H:
[23-268]
------------------
H
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
-
A
--
L
N
N
V
S
L
H
V
P
A
--
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
----
E
R
P
--------
T
E
G
S
V
L
V
D
G
-------------
Q
E
L
T
T
L-------
S
E
-----------
S
E
---
L
T
K
A
R
R
Q
-
I
G
M
I
F
Q
H
F
N
--
L
L
S
S
R
-
T
V
F
G
N
V
------
A
L
P
L
--
E
L
D
N
T
-
P
-
K
D
E
V
K
R
R
V
T
E
L
----
L
S
L
V
---
G
L
G
D
---------
K
H
-------
D
S
Y
P
S
--
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
-
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
--
N
-
R
R
LG
L
--
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
-
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
--
T
P
L
A
Q
K
F
I
Q
S
T
L
----------------------------------------------------------------------------------------------
38
PsiBlast_CBE
85.37
33%
-71
- C1 -
3TUZ
1
METN_ECOLI
G:
[24-268]
-------------------
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
-
A
--
L
N
N
V
S
L
H
V
P
A
--
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
----
E
R
P
--------
T
E
G
S
V
L
V
D
G
-------------
Q
E
L
T
T
L-------
S
E
-----------
S
E
---
L
T
K
A
R
R
Q
-
I
G
M
I
F
Q
H
F
N
--
L
L
S
S
R
-
T
V
F
G
N
V
------
A
L
P
L
--
E
L
D
N
T
-
P
-
K
D
E
V
K
R
R
V
T
E
L
----
L
S
L
V
---
G
L
G
D
---------
K
H
-------
D
S
Y
P
S
--
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
-
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
--
N
-
R
R
LG
L
--
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
-
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
--
T
P
L
A
Q
K
F
I
Q
S
T
L
----------------------------------------------------------------------------------------------
40
PsiBlast_CBE
85.29
33%
-73
- C1 -
3TUI
1
METN_ECOLI
H:
[23-268]
------------------
H
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
-
A
--
L
N
N
V
S
L
H
V
P
A
--
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
----
E
R
P
--------
T
E
G
S
V
L
V
D
G
-------------
Q
E
L
T
T
L-------
S
E
-----------
S
E
---
L
T
K
A
R
R
Q
-
I
G
M
I
F
Q
H
F
N
--
L
L
S
S
R
-
T
V
F
G
N
V
------
A
L
P
L
--
E
L
D
N
T
-
P
-
K
D
E
V
K
R
R
V
T
E
L
----
L
S
L
V
---
G
L
G
D
---------
K
H
-------
D
S
Y
P
S
--
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
-
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
--
N
-
R
R
LG
L
--
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
-
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
--
T
P
L
A
Q
K
F
I
Q
S
T
L
----------------------------------------------------------------------------------------------
15
PsiBlast_PDB
84.75
33%
-72
- C1 -
3TUI
1
METN_ECOLI
C:
[23-268]
------------------
H
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
-
A
--
L
N
N
V
S
L
H
V
P
A
--
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
----
E
R
P
--------
T
E
G
S
V
L
V
D
G
-------------
Q
E
L
T
T
L-------
S
E
-----------
S
E
---
L
T
K
A
R
R
Q
-
I
G
M
I
F
Q
H
F
N
--
L
L
S
S
R
-
T
V
F
G
N
V
------
A
L
P
L
--
E
L
D
N
T
-
P
-
K
D
E
V
K
R
R
V
T
E
L
----
L
S
L
V
---
G
L
G
D
---------
K
H
-------
D
S
Y
P
S
--
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
-
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
--
N
-
R
R
LG
L
--
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
-
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
--
T
P
L
A
Q
K
F
I
Q
S
T
L
----------------------------------------------------------------------------------------------
24
PsiBlast_CBE
83.94
39%
-88
- C1 -
3C4J
4
?
B:
[34-263]
---------------------------------
F
G
S
L
E
-
V
--
L
K
G
I
N
V
H
I
R
E
--
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
----
E
D
-
F
D
-------
E
G
E
I
I
I
D
G
-------------
I
N
L
K
A
--------
K
D
-----------
T
N
---
L
N
K
V
R
E
E
-
V
G
M
V
F
Q
R
F
N
--
L
F
P
-
H
M
T
V
L
N
N
I
------
T
L
A
------
P
M
-
K
V
R
K
W
P
R
E
K
A
E
A
------
K
A
M
---
E
L
L
D
K
V
GL-----
K
D
-------
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
--
A
-
N
E
G-
M
--
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
--
H
E
R
T
K
A
F
L
S
K
V
F
----------------------------------------------------------------------------------------------
41
PsiBlast_CBE
83.76
33%
-66
- C1 -
3TUI
1
METN_ECOLI
G:
[24-268]
-------------------
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
-
A
--
L
N
N
V
S
L
H
V
P
A
--
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
----
E
R
P
--------
T
E
G
S
V
L
V
D
G
-------------
Q
E
L
T
T
L-------
S
E
-----------
S
E
---
L
T
K
A
R
R
Q
-
I
G
M
I
F
Q
H
F
N
--
L
L
S
S
R
-
T
V
F
G
N
V
------
A
L
P
L
--
E
L
D
N
T
-
P
-
K
D
E
V
K
R
R
V
T
E
L
----
L
S
L
V
---
G
L
G
D
---------
K
H
-------
D
S
Y
P
S
--
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
-
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
--
N
-
R
R
LG
L
--
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
-
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
--
T
P
L
A
Q
K
F
I
Q
S
T
L
----------------------------------------------------------------------------------------------
19
PsiBlast_PDB
83.60
35%
-87
- C1 -
1B0U
4
HISP_SALTY
A:
[11-257]
----------------------------
D
L
H
K
R
Y
G
G
H
E
-
V
--
L
K
G
V
S
L
Q
A
R
A
--
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
----
E
K
P
--------
S
E
G
A
I
I
V
N
G
-------------
Q
N
I
N
L
V
R
D
KDGQL
K
V
-----------
A
D
K
N
Q
L
R
L
L
R
T
R
-
L
T
M
V
F
Q
H
F
N
--
L
W
S
-
H
M
T
V
L
E
N
V
M
EAPIQ
V
L
G
L
--
S
K
H
D
A
-
R
------
E
R
A
L
K
Y
----
L
A
K
V
---
G
I
D
E
R
A
-------
Q
----------
G
K
Y
P
V
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
-
E
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
L
R
I
M
Q
Q
L
--
A
-
E
E
G-
K
--
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
H
Q
-
G
K
I
E
E
E
G
D
P
E
Q
V
F
G
N
P
Q
--
S
P
R
L
Q
Q
F
L
K
G
S
L
----------------------------------------------------------------------------------------------
29
PsiBlast_CBE
83.28
39%
-83
- C1 -
2OLK
1
?
D:
[34-263]
---------------------------------
F
G
S
L
E
-
V
--
L
K
G
I
N
V
H
I
R
E
--
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
----
E
D
-
F
D
-------
E
G
E
I
I
I
D
G
-------------
I
N
L
K
A
--------
K
D
-----------
T
N
---
L
N
K
V
R
E
E
-
V
G
M
V
F
Q
R
F
N
--
L
F
P
-
H
M
T
V
L
N
N
I
------
T
L
A
------
P
M
-
K
V
R
K
W
P
R
E
K
A
E
A
------
K
A
M
---
E
L
L
D
K
V
GL-----
K
D
-------
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
--
A
-
N
E
G-
M
--
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
--
H
E
R
T
K
A
F
L
S
K
V
F
----------------------------------------------------------------------------------------------
27
PsiBlast_CBE
83.27
39%
-83
- C1 -
2OUK
1
?
C:
[34-263]
---------------------------------
F
G
S
L
E
-
V
--
L
K
G
I
N
V
H
I
R
E
--
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
----
E
D
-
F
D
-------
E
G
E
I
I
I
D
G
-------------
I
N
L
K
A
--------
K
D
-----------
T
N
---
L
N
K
V
R
E
E
-
V
G
M
V
F
Q
R
F
N
--
L
F
P
-
H
M
T
V
L
N
N
I
------
T
L
A
------
P
M
-
K
V
R
K
W
P
R
E
K
A
E
A
------
K
A
M
---
E
L
L
D
K
V
GL-----
K
D
-------
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
--
A
-
N
E
G-
M
--
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
--
H
E
R
T
K
A
F
L
S
K
V
F
----------------------------------------------------------------------------------------------
32
PsiBlast_CBE
83.13
39%
-81
- C1 -
2OLJ
3
?
B:
[34-263]
---------------------------------
F
G
S
L
E
-
V
--
L
K
G
I
N
V
H
I
R
E
--
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
----
E
D
-
F
D
-------
E
G
E
I
I
I
D
G
-------------
I
N
L
K
A
--------
K
D
-----------
T
N
---
L
N
K
V
R
E
E
-
V
G
M
V
F
Q
R
F
N
--
L
F
P
-
H
M
T
V
L
N
N
I
------
T
L
A
------
P
M
-
K
V
R
K
W
P
R
E
K
A
E
A
------
K
A
M
---
E
L
L
D
K
V
GL-----
K
D
-------
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
--
A
-
N
E
G-
M
--
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
--
H
E
R
T
K
A
F
L
S
K
V
F
----------------------------------------------------------------------------------------------
8
PsiBlast_PDB
83.05
39%
-76
- C1 -
3C41
3
?
J:
[13-242]
---------------------------------
F
G
S
L
E
-
V
--
L
K
G
I
N
V
H
I
R
E
--
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
----
E
D
-
F
D
-------
E
G
E
I
I
I
D
G
-------------
I
N
L
K
A
--------
K
D
-----------
T
N
---
L
N
K
V
R
E
E
-
V
G
M
V
F
Q
R
F
N
--
L
F
P
-
H
M
T
V
L
N
N
I
------
T
L
A
------
P
M
-
K
V
R
K
W
P
R
E
K
A
E
A
------
K
A
M
---
E
L
L
D
K
V
GL-----
K
D
-------
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
--
A
-
N
E
G-
M
--
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
--
H
E
R
T
K
A
F
L
S
K
V
F
----------------------------------------------------------------------------------------------
7
PsiBlast_PDB
83.05
39%
-81
- C1 -
3C4J
3
?
A:
[34-263]
---------------------------------
F
G
S
L
E
-
V
--
L
K
G
I
N
V
H
I
R
E
--
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
----
E
D
-
F
D
-------
E
G
E
I
I
I
D
G
-------------
I
N
L
K
A
--------
K
D
-----------
T
N
---
L
N
K
V
R
E
E
-
V
G
M
V
F
Q
R
F
N
--
L
F
P
-
H
M
T
V
L
N
N
I
------
T
L
A
------
P
M
-
K
V
R
K
W
P
R
E
K
A
E
A
------
K
A
M
---
E
L
L
D
K
V
GL-----
K
D
-------
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
--
A
-
N
E
G-
M
--
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
--
H
E
R
T
K
A
F
L
S
K
V
F
----------------------------------------------------------------------------------------------
4
PsiBlast_PDB
83.00
39%
-81
- C1 -
2OLK
1
?
A:
[34-263]
---------------------------------
F
G
S
L
E
-
V
--
L
K
G
I
N
V
H
I
R
E
--
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
----
E
D
-
F
D
-------
E
G
E
I
I
I
D
G
-------------
I
N
L
K
A
--------
K
D
-----------
T
N
---
L
N
K
V
R
E
E
-
V
G
M
V
F
Q
R
F
N
--
L
F
P
-
H
M
T
V
L
N
N
I
------
T
L
A
------
P
M
-
K
V
R
K
W
P
R
E
K
A
E
A
------
K
A
M
---
E
L
L
D
K
V
GL-----
K
D
-------
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
--
A
-
N
E
G-
M
--
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
--
H
E
R
T
K
A
F
L
S
K
V
F
----------------------------------------------------------------------------------------------
39
PsiBlast_CBE
82.82
33%
-68
- C1 -
3TUZ
1
METN_ECOLI
D:
[24-268]
-------------------
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
-
A
--
L
N
N
V
S
L
H
V
P
A
--
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
----
E
R
P
--------
T
E
G
S
V
L
V
D
G
-------------
Q
E
L
T
T
L-------
S
E
-----------
S
E
---
L
T
K
A
R
R
Q
-
I
G
M
I
F
Q
H
F
N
--
L
L
S
S
R
-
T
V
F
G
N
V
------
A
L
P
L
--
E
L
D
N
T
-
P
-
K
D
E
V
K
R
R
V
T
E
L
----
L
S
L
V
---
G
L
G
D
---------
K
H
-------
D
S
Y
P
S
--
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
-
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
--
N
-
R
R
LG
L
--
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
-
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
--
T
P
L
A
Q
K
F
I
Q
S
T
L
----------------------------------------------------------------------------------------------
3
PsiBlast_PDB
82.77
39%
-84
- C1 -
2OLJ
4
?
A:
[34-263]
---------------------------------
F
G
S
L
E
-
V
--
L
K
G
I
N
V
H
I
R
E
--
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
----
E
D
-
F
D
-------
E
G
E
I
I
I
D
G
-------------
I
N
L
K
A
--------
K
D
-----------
T
N
---
L
N
K
V
R
E
E
-
V
G
M
V
F
Q
R
F
N
--
L
F
P
-
H
M
T
V
L
N
N
I
------
T
L
A
------
P
M
-
K
V
R
K
W
P
R
E
K
A
E
A
------
K
A
M
---
E
L
L
D
K
V
GL-----
K
D
-------
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
--
A
-
N
E
G-
M
--
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
--
H
E
R
T
K
A
F
L
S
K
V
F
----------------------------------------------------------------------------------------------
30
PsiBlast_CBE
82.67
39%
-82
- C1 -
2OLK
1
?
C:
[34-263]
---------------------------------
F
G
S
L
E
-
V
--
L
K
G
I
N
V
H
I
R
E
--
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
----
E
D
-
F
D
-------
E
G
E
I
I
I
D
G
-------------
I
N
L
K
A
--------
K
D
-----------
T
N
---
L
N
K
V
R
E
E
-
V
G
M
V
F
Q
R
F
N
--
L
F
P
-
H
M
T
V
L
N
N
I
------
T
L
A
------
P
M
-
K
V
R
K
W
P
R
E
K
A
E
A
------
K
A
M
---
E
L
L
D
K
V
GL-----
K
D
-------
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
--
A
-
N
E
G-
M
--
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
--
H
E
R
T
K
A
F
L
S
K
V
F
----------------------------------------------------------------------------------------------
33
PsiBlast_CBE
82.64
39%
-81
- C1 -
3C41
3
?
K:
[13-242]
---------------------------------
F
G
S
L
E
-
V
--
L
K
G
I
N
V
H
I
R
E
--
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
----
E
D
-
F
D
-------
E
G
E
I
I
I
D
G
-------------
I
N
L
K
A
--------
K
D
-----------
T
N
---
L
N
K
V
R
E
E
-
V
G
M
V
F
Q
R
F
N
--
L
F
P
-
H
M
T
V
L
N
N
I
------
T
L
A
------
P
M
-
K
V
R
K
W
P
R
E
K
A
E
A
------
K
A
M
---
E
L
L
D
K
V
GL-----
K
D
-------
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
--
A
-
N
E
G-
M
--
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
--
H
E
R
T
K
A
F
L
S
K
V
F
----------------------------------------------------------------------------------------------
31
PsiBlast_CBE
82.06
39%
-86
- C1 -
2OLK
2
?
B:
[34-263]
---------------------------------
F
G
S
L
E
-
V
--
L
K
G
I
N
V
H
I
R
E
--
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
----
E
D
-
F
D
-------
E
G
E
I
I
I
D
G
-------------
I
N
L
K
A
--------
K
D
-----------
T
N
---
L
N
K
V
R
E
E
-
V
G
M
V
F
Q
R
F
N
--
L
F
P
-
H
M
T
V
L
N
N
I
------
T
L
A
------
P
M
-
K
V
R
K
W
P
R
E
K
A
E
A
------
K
A
M
---
E
L
L
D
K
V
GL-----
K
D
-------
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
--
A
-
N
E
G-
M
--
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
--
H
E
R
T
K
A
F
L
S
K
V
F
----------------------------------------------------------------------------------------------
35
PsiBlast_CBE
81.84
37%
-78
- C1 -
4YMU
2
?
A:
[6-237]
----------------------------
D
V
Y
K
N
F
G
S
L
E
-
V
--
L
K
G
V
T
L
K
V
N
K
--
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
----
E
E
P
T
--------
K
G
E
V
F
I
D
G
-------------
V
K
I
N
N
--------
G
K
-----------
V
N
---
I
N
K
V
R
Q
K
-
V
G
M
V
F
Q
H
F
N
--
L
F
P
-
H
L
T
A
I
E
N
I
------
T
L
A
P
--
V
K
V
K
K
-
M
N
K
K
E
A
E
E
L
A
V
D
L
----
L
A
K
V
---
G
L
L
D
K
--------
K
D
----------
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
--
A
-
N
E
G-
M
--
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
-
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
--
N
E
R
T
R
E
F
L
S
-------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
81.56
39%
-79
- C1 -
2Q0H
4
?
A:
[34-263]
---------------------------------
F
G
S
L
E
-
V
--
L
K
G
I
N
V
H
I
R
E
--
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
----
E
D
-
F
D
-------
E
G
E
I
I
I
D
G
-------------
I
N
L
K
A
--------
K
D
-----------
T
N
---
L
N
K
V
R
E
E
-
V
G
M
V
F
Q
R
F
N
--
L
F
P
-
H
M
T
V
L
N
N
I
------
T
L
A
------
P
M
-
K
V
R
K
W
P
R
E
K
A
E
A
------
K
A
M
---
E
L
L
D
K
V
GL-----
K
D
-------
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
--
A
-
N
E
G-
M
--
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
--
H
E
R
T
K
A
F
L
S
K
V
F
----------------------------------------------------------------------------------------------
1
PsiBlast_PDB
80.91
36%
-81
- C1 -
4U00
3
?
A:
[9-239]
----------------------------
N
L
H
K
W
F
G
P
L
H
-
V
--
L
K
G
I
H
L
E
V
A
P
--
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
----
E
D
-----
F
---
Q
E
G
E
V
V
V
D
G
-------------
L
S
V
-
K
--------
D
D
-----------
R
A
---
L
R
E
I
R
R
E
-
V
G
M
V
F
Q
Q
F
N
--
L
F
P
-
H
M
T
V
L
E
N
V
------
T
L
A
------
P
M
-
R
V
R
R
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
---
G
I
L
D
Q
A
-------
R
-----------
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
D
V
M
R
D
L
A
-
Q
-
G
G
--
M
--
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
-
G
Q
I
V
E
E
G
R
P
E
E
I
F
T
R
P
K
--
E
E
R
T
R
S
F
L
Q
-------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
80.61
37%
-78
- C1 -
4YMU
2
?
J:
[6-237]
----------------------------
D
V
Y
K
N
F
G
S
L
E
-
V
--
L
K
G
V
T
L
K
V
N
K
--
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
----
E
E
P
T
--------
K
G
E
V
F
I
D
G
-------------
V
K
I
N
N
--------
G
K
-----------
V
N
---
I
N
K
V
R
Q
K
-
V
G
M
V
F
Q
H
F
N
--
L
F
P
-
H
L
T
A
I
E
N
I
------
T
L
A
P
--
V
K
V
K
K
-
M
N
K
K
E
A
E
E
L
A
V
D
L
----
L
A
K
V
---
G
L
L
D
K
--------
K
D
----------
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
--
A
-
N
E
G-
M
--
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
-
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
--
N
E
R
T
R
E
F
L
S
-------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
80.24
39%
-82
- C1 -
2Q0H
4
?
B:
[34-263]
---------------------------------
F
G
S
L
E
-
V
--
L
K
G
I
N
V
H
I
R
E
--
G
E
V
V
V
V
I
G
P
S
G
S
G
K
S
T
F
L
R
C
L
N
L
L
----
E
D
-
F
D
-------
E
G
E
I
I
I
D
G
-------------
I
N
L
K
A
--------
K
D
-----------
T
N
---
L
N
K
V
R
E
E
-
V
G
M
V
F
Q
R
F
N
--
L
F
P
-
H
M
T
V
L
N
N
I
------
T
L
A
------
P
M
-
K
V
R
K
W
P
R
E
K
A
E
A
------
K
A
M
---
E
L
L
D
K
V
GL-----
K
D
-------
K
A
H
A
Y
P
D
S
L
S
G
G
Q
A
Q
R
V
A
I
A
R
A
L
A
M
-
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
G
E
V
L
S
V
M
K
Q
L
--
A
-
N
E
G-
M
--
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
L
F
M
D
G
-
G
Y
I
I
E
E
G
K
P
E
D
L
F
D
R
P
Q
--
H
E
R
T
K
A
F
L
S
K
V
F
----------------------------------------------------------------------------------------------
34
PsiBlast_CBE
79.93
37%
-78
- C1 -
4YMV
1
?
A:
[6-237]
----------------------------
D
V
Y
K
N
F
G
S
L
E
-
V
--
L
K
G
V
T
L
K
V
N
K
--
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
----
E
E
P
T
--------
K
G
E
V
F
I
D
G
-------------
V
K
I
N
N
--------
G
K
-----------
V
N
---
I
N
K
V
R
Q
K
-
V
G
M
V
F
Q
H
F
N
--
L
F
P
-
H
L
T
A
I
E
N
I
------
T
L
A
P
--
V
K
V
K
K
-
M
N
K
K
E
A
E
E
L
A
V
D
L
----
L
A
K
V
---
G
L
L
D
K
--------
K
D
----------
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
--
A
-
N
E
G-
M
--
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
-
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
--
N
E
R
T
R
E
F
L
S
-------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
78.96
37%
-80
- C1 -
4YMV
1
?
J:
[6-237]
----------------------------
D
V
Y
K
N
F
G
S
L
E
-
V
--
L
K
G
V
T
L
K
V
N
K
--
G
E
V
V
V
I
I
G
P
S
G
S
G
K
S
T
L
L
R
C
I
N
L
L
----
E
E
P
T
--------
K
G
E
V
F
I
D
G
-------------
V
K
I
N
N
--------
G
K
-----------
V
N
---
I
N
K
V
R
Q
K
-
V
G
M
V
F
Q
H
F
N
--
L
F
P
-
H
L
T
A
I
E
N
I
------
T
L
A
P
--
V
K
V
K
K
-
M
N
K
K
E
A
E
E
L
A
V
D
L
----
L
A
K
V
---
G
L
L
D
K
--------
K
D
----------
Q
Y
P
I
K
L
S
G
G
Q
K
Q
R
L
A
I
A
R
A
L
A
M
-
Q
P
E
V
M
L
F
D
E
P
T
S
A
L
D
P
E
M
V
K
E
V
L
N
V
M
K
Q
L
--
A
-
N
E
G-
M
--
T
M
V
V
V
T
H
E
M
G
F
A
R
E
V
G
D
R
V
I
F
M
D
D
-
G
V
I
V
E
E
G
T
P
E
E
I
F
Y
R
A
K
--
N
E
R
T
R
E
F
L
S
-------------------------------------------------------------------------------------------------
97
Fugue
78.91
34%
-76
- C1 -
1B0U
4
HISP_SALTY
A:
[5-261]
---------
N
K
L
H
V
I
D
L
H
K
R
Y
G
G
---
H
E
V
L
K
-------------
G
V
S
L
Q
A
R
A
--
G
D
V
I
S
I
I
G
S
S
G
S
G
K
S
T
F
L
R
C
I
N
F
L
EKPS------------
E
G
A
I
I
V
N
G
QNI
N
L
V
R
D
KDGQL
K
V
A
D
K
--------
N
Q
-----------
L
R
---
L
L
R
T
-
R
--
L
T
M
V
F
Q
H
F
N
--
L
W
S
-
H
M
T
V
L
E
N
V
------
M
E
A
P
--
I
Q
V
L
-G
L
S
K
H
D
A
R
E
R
A
L
K
Y
----
L
A
K
V
---
G
I
D
E
R
A
-------
Q
G
----------
K
Y
P
V
H
L
S
G
G
Q
Q
Q
R
V
S
I
A
R
A
L
A
M
E-
P
D
V
L
L
F
D
E
P
T
S
A
L
D
P
E
L
V
G
E
V
L
R
I
M
Q
Q
L
--
A
-
E
E
G-
K
--
T
M
V
V
V
T
H
E
M
G
F
A
R
H
V
S
S
H
V
I
F
L
H
-Q
G
K
I
E
E
E
G
D
P
E
Q
V
F
G
N
P
-QS
P
R
L
Q
Q
F
L
K
G
S
L
K
K
LE-------------------------------------------------------------------------------------------
48
PsiBlast_CBE
69.06
31%
-81
- C1 -
1VCI
1
?
A:
[16-251]
---------------------------
E
N
L
T
K
R
F
G
N
F
T
-
A
--
V
N
K
L
N
L
T
I
K
D
--
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
----
E
E
P
T
--------
E
G
R
I
Y
F
G
-----------------
D
R
--------
D
V
-----------
T
Y
---
L
P
P
K
D
R
N
-
I
S
M
V
F
Q
---------
H
M
T
V
Y
E
N
I
------
A
F
P
L
----------
K
K
F
P
K
D
E
I
D
K
R
----
V
R
W
A
---
A
E
L
L
Q
I
-------
E
E
-------
L
L
N
R
Y
P
A
Q
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
-
E
P
D
V
L
L
M
D
E
P
L
S
N
L
D
A
K
L
R
V
A
M
R
A
E
I
K
K
L
Q
Q
K
-
L
K
--
V
--
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
R
-
G
Q
L
L
Q
I
G
S
P
T
E
V
Y
L
R
P
N
--
S
V
F
V
A
T
F
I
G
A
------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
67.64
34%
-82
- C1 -
1L2T
4
Y796_METJA
B:
[19-223]
-------------------------------------
Y
-
A
--
L
K
N
V
N
L
N
I
K
E
--
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
------------
I
I
G
C
L
DKP
T
E
G
E
V
Y
I
D
N
-------------
I
K
T
N
D
--------
L
D
-----------
D
D
E--
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
Q
F
N
LI
P
L
L
-
T
-
A
L
-
E
N
V
------
E
L
P
L
IF
K
Y
R
G
A
-
M
S
G
E
E
R
R
K
R
A
L
E
C
----
L
K
M
A
---
E
L
E
E
R
F
-------
A
N
----------
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
-
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
NE
E
-
D
G
--
K
--
T
V
V
V
V
T
H
D
I
-
N
V
A
R
F
G
E
R
I
I
Y
L
K
D
-
G
E
V
--------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
67.32
34%
-81
- C1 -
1L2T
4
Y796_METJA
A:
[19-223]
-------------------------------------
Y
-
A
--
L
K
N
V
N
L
N
I
K
E
--
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
------------
I
I
G
C
L
DKP
T
E
G
E
V
Y
I
D
N
-------------
I
K
T
N
D
--------
L
D
-----------
D
D
E
--
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
Q
F
N
LI
P
L
L
-
T
-
A
L
-
E
N
V
------
E
L
P
L
IF
K
Y
R
G
A
-
M
S
G
E
E
R
R
K
R
A
L
E
C
----
L
K
M
A
---
E
L
E
E
R
F
-------
A
N
----------
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
-
N
P
P
I
I
L
A
D
Q
P
T
G
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
-
D
G
--
K
--
T
V
V
V
V
T
H
D
I
-
N
V
A
R
F
G
E
R
I
I
Y
L
K
D
-
G
E
V
--------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
66.92
34%
-82
- C1 -
3TIF
6
Y796_METJA
B:
[19-223]
-------------------------------------
Y
-
A
--
L
K
N
V
N
L
N
I
K
E
--
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
------------
I
I
G
C
L
DKP
T
E
G
E
V
Y
I
D
N
-------------
I
K
T
N
D
--------
L
D
-----------
D
D
E--
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
Q
F
N
LI
P
L
L
-
T
-
A
L
-
E
N
V
------
E
L
P
L
IF
K
Y
R
G
A
-
M
S
G
E
E
R
R
K
R
A
L
E
C
----
L
K
M
A
---
E
L
E
E
R
F
-------
A
N
----------
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
-
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
NE
E
-
D
G
--
K
--
T
V
V
V
V
T
H
D
I
-
N
V
A
R
F
G
E
R
I
I
Y
L
K
D
-
G
E
V
--------------------------------------------------------------------------------------------------------------------------
77
PsiBlast_CBE
66.38
34%
-79
- C1 -
3TIF
7
Y796_METJA
A:
[19-223]
-------------------------------------
Y
-
A
--
L
K
N
V
N
L
N
I
K
E
--
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
------------
I
I
G
C
L
DKP
T
E
G
E
V
Y
I
D
N
-------------
I
K
T
N
D
--------
L
D
-----------
D
D
E
--
L
T
K
I
R
R
D
K
I
G
F
V
F
Q
Q
F
N
LI
P
L
L
-
T
-
A
L
-
E
N
V
------
E
L
P
L
IF
K
Y
R
G
A
-
M
S
G
E
E
R
R
K
R
A
L
E
C
----
L
K
M
A
---
E
L
E
E
R
F
-------
A
N
----------
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
-
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
E
-
D
G
--
K
--
T
V
V
V
V
T
H
D
I
-
N
V
A
R
F
G
E
R
I
I
Y
L
K
D
-
G
E
V
--------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
59.81
31%
-77
- C1 -
2ONJ
4
Y1866_STAAM
A:
[349-562]
---------------------------------
Y
N
D
N
E
-
A
PI
L
K
D
I
N
L
S
I
E
K
--
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
----
Y
D
V
--------
T
S
G
Q
I
L
I
D
G
-------------
H
N
I
----------
K
D
-----------
F
L
---
T
G
S
L
R
N
Q
-
I
G
L
V
Q
Q
D
N
I
--
L
F
S
-
D
-
T
V
K
E
N
I
------
L
L
G
----------
R
P
T
A
T
D
E
E
V
V
E
A
----
A
K
M
A
---
N
A
H
D
F
I
-------
M
N
LPQGYDT
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
-
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
--
S
-
K
D
--
R
--
T
T
L
I
V
A
H
R
L
S
T
I
T
H
-
A
D
K
I
V
V
I
E
N
-
G
H
I
V
E
T
G
T
H
R
E
L
-----------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
58.42
31%
-77
- C1 -
2ONJ
4
Y1866_STAAM
B:
[349-562]
---------------------------------
Y
N
D
N
E
-
A
PI
L
K
D
I
N
L
S
I
E
K
--
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
----
Y
D
V
--------
T
S
G
Q
I
L
I
D
G
-------------
H
N
I
----------
K
D
-----------
F
L
---
T
G
S
L
R
N
Q
-
I
G
L
V
Q
Q
D
N
I
--
L
F
S
-
D
-
T
V
K
E
N
I
------
L
L
G
----------
R
P
T
A
T
D
E
E
V
V
E
A
----
A
K
M
A
---
N
A
H
D
F
I
-------
M
N
LPQGYDT
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
-
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
--
S
-
K
D
--
R
--
T
T
L
I
V
A
H
R
L
S
T
I
T
H
-
A
D
K
I
V
V
I
E
N
-
G
H
I
V
E
T
G
T
H
R
E
L
-----------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
58.01
31%
-79
- C1 -
2HYD
3
Y1866_STAAM
A:
[349-562]
---------------------------------
Y
N
D
N
E
-
A
PI
L
K
D
I
N
L
S
I
E
K
--
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
----
Y
D
V
--------
T
S
G
Q
I
L
I
D
G
-------------
H
N
I
----------
K
D
-----------
F
L
---
T
G
S
L
R
N
Q
-
I
G
L
V
Q
Q
D
N
I
--
L
F
S
-
D
-
T
V
K
E
N
I
------
L
L
G
----------
R
P
T
A
T
D
E
E
V
V
E
A
----
A
K
M
A
---
N
A
H
D
F
I
-------
M
N
LPQGYDT
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
-
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
--
S
-
K
D
--
R
--
T
T
L
I
V
A
H
R
L
S
T
I
T
H
-
A
D
K
I
V
V
I
E
N
-
G
H
I
V
E
T
G
T
H
R
E
L
-----------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
57.62
31%
-79
- C1 -
2HYD
3
Y1866_STAAM
B:
[349-562]
---------------------------------
Y
N
D
N
E
-
A
PI
L
K
D
I
N
L
S
I
E
K
--
G
E
T
V
A
F
V
G
M
S
G
G
G
K
S
T
L
I
N
L
I
P
R
F
----
Y
D
V
--------
T
S
G
Q
I
L
I
D
G
-------------
H
N
I
----------
K
D
-----------
F
L
---
T
G
S
L
R
N
Q
-
I
G
L
V
Q
Q
D
N
I
--
L
F
S
-
D
-
T
V
K
E
N
I
------
L
L
G
----------
R
P
T
A
T
D
E
E
V
V
E
A
----
A
K
M
A
---
N
A
H
D
F
I
-------
M
N
LPQGYDT
E
V
G
E
R
G
V
K
L
S
G
G
Q
K
Q
R
L
S
I
A
R
I
F
L
N
-
N
P
P
I
L
I
L
D
E
A
T
S
A
L
D
L
E
S
E
S
I
I
Q
E
A
L
D
V
L
--
S
-
K
D
--
R
--
T
T
L
I
V
A
H
R
L
S
T
I
T
H
-
A
D
K
I
V
V
I
E
N
-
G
H
I
V
E
T
G
T
H
R
E
L
-----------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
53.43
32%
-92
- C1 -
3NHB
3
A:
[57-249]
---------------------------
E
N
V
H
F
S
Y
A
D
-
R
E
T
--
L
Q
D
V
S
F
T
V
M
P
--
G
Q
T
L
A
L
V
G
P
S
G
A
G
K
S
T
I
L
R
L
L
F
R
F
----
Y
D
I
S
S
G
C
--------
I
R
I
D
G
-------------
Q
D
I
S
----------
Q
-----------
V
T
---
Q
A
S
L
R
S
H
-
I
G
V
V
P
Q
D
T
V
--
L
F
N
-
D
-
T
I
A
D
N
I
------
R
Y
G
R
--
V
T
A
G
N
--------
D
E
V
E
A
A
----
A
Q
A
A
---
G
I
H
D
A
I
M
A
FPEGY
R
T
-------
Q
V
G
E
R
G
L
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
I
L
K
-
A
P
G
I
I
L
L
D
E
A
T
S
A
L
D
T
S
N
E
R
A
I
Q
A
S
L
A
K
V
--
C
-
A
N
--
R
--
T
T
I
V
V
A
H
R
L
---------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
53.35
32%
-89
- C1 -
3NH9
3
A:
[57-249]
---------------------------
E
N
V
H
F
S
Y
A
D
G
R
E
T
--
L
Q
D
V
S
F
T
V
M
P
--
G
Q
T
L
A
L
V
G
P
S
G
A
G
K
S
T
I
L
R
L
L
F
R
F
----
Y
D
I
S
S
G
C
--------
I
R
I
D
G
-------------
Q
D
I
S
----------
Q
-----------
V
T
---
Q
A
S
L
R
S
H
-
I
G
V
V
P
Q
D
T
V
--
L
F
N
-
D
-
T
I
A
D
N
I
------
R
Y
G
R
--
V
T
A
G
N
--------
D
E
V
E
A
A
----
A
Q
A
A
---
G
I
H
D
A
I
M
A
FPEGY
R
T
-------
Q
V
G
E
R
G
L
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
I
L
K
-
A
P
G
I
I
L
L
D
E
A
T
S
A
L
D
T
S
N
E
R
A
I
Q
A
S
L
A
K
V
--
C
-
A
N
--
R
--
T
T
I
V
V
A
H
R
L
---------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
53.13
32%
-93
- C1 -
3NHA
4
A:
[57-249]
---------------------------
E
N
V
H
F
S
Y
A
D
-
R
E
T
--
L
Q
D
V
S
F
T
V
M
P
--
G
Q
T
L
A
L
V
G
P
S
G
A
G
K
S
T
I
L
R
L
L
F
R
F
----
Y
D
I
S
S
G
C
--------
I
R
I
D
G
-------------
Q
D
I
S
----------
Q
-----------
V
T
---
Q
A
S
L
R
S
H
-
I
G
V
V
P
Q
D
T
V
--
L
F
N
-
D
-
T
I
A
D
N
I
------
R
Y
G
R
--
V
T
A
G
N
--------
D
E
V
E
A
A
----
A
Q
A
A
---
G
I
H
D
A
I
M
A
FPEGY
R
T
-------
Q
V
G
E
R
G
L
K
L
S
G
G
E
K
Q
R
V
A
I
A
R
T
I
L
K
-
A
P
G
I
I
L
L
D
E
A
T
S
A
L
D
T
S
N
E
R
A
I
Q
A
S
L
A
K
V
--
C
-
A
N
--
R
--
T
T
I
V
V
A
H
R
L
---------------------------------------------------------------------------------------------------------------------------------------------
79
PsiBlast_CBE
39.37
31%
-68
- C1 -
1MV5
1
LMRA_LACLA
C:
[20-198]
----------------------------------------------
D
I
S
F
E
A
QP
N
S
I
I
A
F
A
G
P
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
----
Y
Q
P
--------
T
A
G
E
I
T
I
D
G
-------------
Q
P
I
D
N
---------------------
I
S
---
L
E
N
W
R
S
Q
-
I
G
F
V
S
Q
D
S
A
--
I
M
A
-
G
-
T
I
R
E
N
L
------
T
Y
G
L
--
E
--
G
D
-
Y
T
D
E
D
L
W
Q
V
L
D
L
A
----
F
A
R
S
FVE
N
M
P
D
Q
L
-------
N
T
-------
E
V
G
E
R
G
V
K
I
S
G
G
Q
R
Q
R
L
A
I
A
R
A
F
L
R
-
N
P
K
I
L
M
L
D
E
A
T
A
S
L
D
S
E
S
E
S
M
V
Q
K
A
L
D
S
L
--
M
-
K
G
--
R
--
T
T
L
V
I
A
H
R
L
---------------------------------------------------------------------------------------------------------------------------------------------
80
PsiBlast_CBE
38.38
31%
-54
- C1 -
1MV5
1
LMRA_LACLA
B:
[20-198]
----------------------------------------------
D
I
S
F
E
A
QP
N
S
I
I
A
F
A
G
P
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
----
Y
Q
P
--------
T
A
G
E
I
T
I
D
G
-------------
Q
P
I
D
N
---------------------
I
S
---
L
E
N
W
R
S
Q
-
I
G
F
V
S
Q
D
S
A
--
I
M
A
-
G
-
T
I
R
E
N
L
------
T
Y
G
L
--
E
--
G
D
-
Y
T
D
E
D
L
W
Q
V
L
D
L
A
----
F
A
R
S
FVE
N
M
P
D
Q
L
-------
N
T
-------
E
V
G
E
R
G
V
K
I
S
G
G
Q
R
Q
R
L
A
I
A
R
A
F
L
R
-
N
P
K
I
L
M
L
D
E
A
T
A
S
L
D
S
E
S
E
S
M
V
Q
K
A
L
D
S
L
--
M
-
K
G
--
R
--
T
T
L
V
I
A
H
R
L
---------------------------------------------------------------------------------------------------------------------------------------------
81
PsiBlast_CBE
38.10
31%
-64
- C1 -
1MV5
2
LMRA_LACLA
A:
[20-198]
----------------------------------------------
D
I
S
F
E
A
Q
P
N
S
I
I
A
F
A
G
P
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
----
Y
Q
P
--------
T
A
G
E
I
T
I
D
G
-------------
Q
P
I
D
N
---------------------
I
S
---
L
E
N
W
R
S
Q
-
I
G
F
V
S
Q
D
S
A
--
I
M
A
-
G
-
T
I
R
E
N
L
------
T
Y
G
L
--
E
--
G
D
-
Y
T
D
E
D
L
W
Q
V
L
D
L
A
----
F
A
R
S
FVE
N
M
P
D
Q
L
-------
N
T
-------
E
V
G
E
R
G
V
K
I
S
G
G
Q
R
Q
R
L
A
I
A
R
A
F
L
R
-
N
P
K
I
L
M
L
D
E
A
T
A
S
L
D
S
E
S
E
S
M
V
Q
K
A
L
D
S
L
--
M
-
K
G
--
R
--
T
T
L
V
I
A
H
R
L
---------------------------------------------------------------------------------------------------------------------------------------------
78
PsiBlast_CBE
37.17
31%
-55
- C1 -
1MV5
2
D:
[20-198]
----------------------------------------------
D
I
S
F
E
A
QP
N
S
I
I
A
F
A
G
P
S
G
G
G
K
S
T
I
F
S
L
L
E
R
F
----
Y
Q
P
--------
T
A
G
E
I
T
I
D
G
-------------
Q
P
I
D
N
---------------------
I
S
---
L
E
N
W
R
S
Q
-
I
G
F
V
S
Q
D
S
A
--
I
M
A
-
G
-
T
I
R
E
N
L
------
T
Y
G
L
--
E
--
G
D
-
Y
T
D
E
D
L
W
Q
V
L
D
L
A
----
F
A
R
S
FVE
N
M
P
D
Q
L
-------
N
T
-------
E
V
G
E
R
G
V
K
I
S
G
G
Q
R
Q
R
L
A
I
A
R
A
F
L
R
-
N
P
K
I
L
M
L
D
E
A
T
A
S
L
D
S
E
S
E
S
M
V
Q
K
A
L
D
S
L
--
M
-
K
G
--
R
--
T
T
L
V
I
A
H
R
L
---------------------------------------------------------------------------------------------------------------------------------------------