@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu09260: (2016-06-14 )
MEMMGMENIQQNQGLKQKDEQFVWHAMKGAHQADSLIAQKAEGAWVTDTDGRRYLDAMSGLWCVNIGYGRKELAEAAYEQLKELPYYPLTQSHAPAIQLAEKLNEWLGGDYVIFFSNSGSEANETAFKIARQYHLQNGDHSRYKFISRYRAYHGNTLGALSATGQAQRKYKYEPLSQGFLHAAPPDIYRNPDDADTLESANEIDRIMTWELSETIAGVIMEPIITGGGILMPPDGYMKKVEDICRRHGALLICDEVICGFGRTGEPFGFMHYGVKPDIITMAKGITSAYLPLSATAVKRDIFEAYQGEAPYDRFRHVNTFGGSPAACALALKNLQIMEDEQLIQRSRDLGAKLLGELQALREHPAVGDVRGKGLLIGIELVKDKLTKEPADAAKVNQVVAACKEKGLIIGKNGDTVAGYNNVIQLAPPFCLTEEDLSFIVKTVKESFQTI
Atome Classification :
(35 SA)
.........10........20....-----.---...30--.---.----..-.--....40........-50--........60.-.......70........80.....-.--.--.-90-.----...--.--....100-.-......110.-.-.......120.......130.......140........150.......160.....-..170..----....---..180.-......----190-----.--.-----...-----...-----200.--.-----.....210..----.....----220.-...-.-..230.......240.......250.......260.......270-....--....280......-.290.......300..-.-.-..-.-310.......320.......330.......340.....-..350--.....-.-..360-..-...-...370.......380......--.--390.--.--.-...-...400...----...---.410.......420.......430----.......440.......450---
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MEMM
G
M
E
N
I
Q
Q
NQGLK
Q
K
D
E
Q
F
V
W
H
-----
A
---
M
KGA---
H
---
Q
----
A
D
-
S
--
L
I
A
QKAEG
A
W
VTDT-D
G
--
R
R
Y
L
D
AMS
G
L
W
-
C
V
NIGY
G
R
K
E
L
A
E
A
A
Y
E
Q
L
K
ELPY-Y--P--L-T--Q----SHA--
P
--
A
I
Q
L
A
E
K
-
L
-
N
E
W
LGG
D
--
Y
-
V
-
I
F
FSNSGSE
A
N
E
T
A
F
K
I
A
R
Q
Y
HLQNG
D
H
S
-
R
Y
K
F
I
S
R
Y
R
A
YHGNTLGALSATGQAQ-RKYK-YE----PLSQ---GFLHAA-P
P
D
IYR----NP------D--
D
-----
A
D
T
-----
L
E
S
-----
A
N
E
I
--
D
-----
R
I
M
T
W
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L
S
E
T
----
I
A
G
V
I
----
M
E
P
I-ITG-G-
G
I
LMPP
D
G
Y
M
K
K
V
E
D
I
C
R
RHG
A
L
L
I
C
D
E
V
I
CGFGRTGEPF
G
F
M
-H-YGVK--P
D
I
I
T
M
A
K
G
I
T
S
A-YLPL
S
A
T
A
V
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-Y-Q-GE-A-
P
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NLQIM
E
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Q
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S
R
-
D
L
G
A
---
K
L
L
G
E
-
L
-
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L
-
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-EH-PAV-GDVRG
K
G
L
L
I
G
I
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L
V
K
D
K
LTKE--P--A--
D
--
A
--
A
-
K
V
N
-
Q
V
V
A
A
C
K
EK----
G
L
I
---IGKNGDTVAGYN
N
V
I
QLAPPFCL
T
----
E
E
D
L
S
F
I
V
K
T
V
K
E
S
FQTI-----
116
HHSearch
74.11
67%
-89
- C1 -
3N5M
6
?
A:
[12-452]
--------------
L
L
A
K
D
E
Q
Y
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---
M
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S
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S
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A
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R
R
Y
Q
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----
P
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---
G
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----
M
P
GIEREN
I
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G
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-
N
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Y
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--
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A
K
G
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S
A
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L
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P
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S
A
T
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R
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-
K
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-
G
-
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F
G
G
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A
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N
L
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I
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N
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A
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---
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L
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N
--
D
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V
V
N
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C
K
E
K
----
G
L
I
---
I
G
R
N
G
M
T
T
A
G
Y
N
N
I
L
T
L
A
P
P
L
V
I
S
----
S
E
E
I
A
F
V
I
G
T
L
K
T
A
M
E
R
I
-----
1
PsiBlast_PDB
73.43
63%
-89
* C1 *
3N5M
6
?
A:
[7-452]
---------
K
Q
T
D
E
L
L
A
K
D
E
Q
Y
V
W
H
-----
G
---
M
R
P
F
---
S
---
P
----
N
S
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T
--
T
V
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K
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I
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--
K
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Y
L
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N
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K
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P
--
M
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----
S
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L
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G
N
T
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A
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M
A
A
T
G
Q
A
Q
-
R
R
Y
Q
-
Y
E
----
P
F
A
S
---
G
F
L
H
V
T
-
P
P
D
C
Y
R
----
M
P
GIER--
E
--
N
-----
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D
-----
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-----
V
K
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--
D
-----
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----
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K
A
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N
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Y
D
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K
--
P
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A
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L
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A
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R
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G
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L
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N
L
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N
E
N
L
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E
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S
A
-
Q
M
G
S
---
L
L
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K
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--
P
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N
--
D
-
K
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A
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V
V
N
A
C
K
E
K
----
G
L
I
---
I
G
R
N
G
M
T
T
A
G
Y
N
N
I
L
T
L
A
P
P
L
V
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----
S
E
E
I
A
F
V
I
G
T
L
K
T
A
M
E
R
I
-----
17
PsiBlast_PDB
56.28
32%
-110
- C1 -
3I5T
2
?
A:
[39-454]
---------------------------------------------------------
V
L
T
H
A
E
G
I
Y
V
H
T
E
-
D
G
--
R
R
L
I
D
G
P
A
G
M
W
-
C
A
Q
V
G
Y
G
R
R
E
I
V
D
A
M
A
H
Q
A
M
V
L
P
Y
A
S
--
P
--
W
-
Y
--
M
----
A
T
S
--
P
--
A
A
R
L
A
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K
-
I
-
A
T
L
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G
D
--
L
N
R
-
I
F
F
T
T
G
G
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S
A
L
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F
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Y
N
N
V
L
G
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K
K
R
I
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Y
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G
Y
H
G
S
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A
L
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A
A
C
T
G
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-
N
W
P
N
-
F
D
-----
I
A
Q
DR
I
S
F
L
S
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P
-
N
P
R
H
A
G
----
N
R
------
S
--
Q
-----
E
A
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-----
L
D
D
-----
L
V
Q
E
F
E
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-----
R
I
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S
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D
T
----
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A
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L
----
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L
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V
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V
F
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P
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A
K
G
V
T
S
G
-
Y
V
P
L
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G
L
A
I
S
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A
V
L
A
R
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I
-
S
-
G
E
N
A
-
K
G
S
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N
G
Y
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Y
S
N
Q
P
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A
A
A
L
A
N
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E
L
M
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G
I
V
D
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R
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E
M
A
D
---
Y
F
A
A
A
-
L
-
A
S
L
-
R
-
D
L
-
P
G
V
-
A
E
T
R
S
V
G
L
V
G
C
V
Q
C
L
L
D
-----GT
A
--
E
--
D
--
K
--
A
-
F
T
L
-
K
I
D
E
R
C
F
E
L
----
G
L
I
---
V
R
P
L
G
D
-------
L
C
V
I
S
P
P
L
I
I
S
----
R
A
Q
I
D
E
M
V
A
I
M
R
Q
A
I
T
E
V
-----
15
PsiBlast_PDB
55.30
33%
-111
- C1 -
3DOD
2
BIOK_BACSU
A:
[5-443]
--------------
L
I
E
K
S
K
K
H
L
W
L
-----
P
---
F
T
Q
M
---
K
---
D
----
Y
D
-
E
N
P
L
I
I
E
S
G
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G
I
K
V
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N
G
--
K
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Y
Y
D
G
F
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S
V
W
-
L
N
V
H
G
H
R
K
K
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L
D
D
A
I
K
K
Q
L
G
K
I
A
H
-
S
--
T
--
L
-
L
G-
M
----
T
N
V
--
P
--
A
T
Q
L
A
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L
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S
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K
K
--
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R
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D
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A
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I
A
L
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M
A
F
Q
Y
W
K
N
I
G
K
P
E
-
K
Q
K
F
I
A
M
K
--------------------------------------
S
Y
K
A
P
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I
P
Y
V
Y
R
SESG
D
P
------
D
--
E
-----
C
R
D
------
Q
C
-----
L
R
E
L
--
A
-----
Q
L
L
E
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E
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H
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----
I
A
A
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S
----
I
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V
Q
G
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D
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A
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K
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G
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Y
L
P
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A
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T
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A
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I
Y
K
A
F
Y
-
D
-
D
Y
-
E
-
N
L
K
T
F
F
H
G
H
S
Y
T
G
N
Q
L
G
C
A
V
A
L
E
N
L
A
L
F
E
S
E
N
I
V
E
Q
V
A
-
E
K
S
K
---
K
L
H
F
L
-
L
-
Q
D
L
-
H
-
A
L
-
P
H
V
-
G
D
I
R
Q
L
G
F
M
C
G
A
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L
V
R
S
K
E
T
K
E
PY
P
--
A
--
D
--
R
--
R
-
I
G
Y
-
K
V
S
L
K
M
R
E
L
----
G
M
L
---
T
R
P
L
G
D
-------
V
I
A
F
L
P
P
L
A
S
T
----
A
E
E
L
S
E
M
V
A
I
M
K
Q
A
I
H
E
V
-----
13
PsiBlast_PDB
55.18
30%
-101
- C1 -
4E3R
2
?
A:
[22-468]
------
N
K
P
Q
S
W
E
A
R
A
E
T
Y
S
L
Y
G
W
T
-----
D
---
M
P
S
L
---
H
---
Q
----
R
G
-
T
--
V
V
V
T
H
G
E
G
P
Y
I
V
D
V
-
N
G
--
R
R
Y
L
D
A
N
S
G
L
F
-
N
M
V
A
G
F
D
H
K
G
L
I
D
A
A
K
A
Q
Y
E
R
F
P
G
-
Y
HA
A
--
F
-
G
--
K
----
M
S
D
--
Q
--
T
V
M
L
S
E
K
-
L
-
V
E
V
S
P
F
D
--
S
G
R
-
V
F
Y
T
N
S
G
S
E
A
N
D
T
M
V
K
M
L
W
F
L
H
A
A
E
G
K
P
Q
-
K
R
K
I
L
T
R
W
N
A
Y
H
G
A
T
A
V
S
A
S
M
T
G
F
P
Y
-
N
S
V
F
-
G
L
----
P
L
P
----
G
F
V
H
L
T
-
C
P
H
Y
W
R
----
Y
G
------
E
--
E
-----
G
E
T
-----
E
E
Q
F
V
A
R
L
A
R
E
L
--
E
-----
E
T
I
Q
R
E
G
A
D
T
----
I
A
G
F
F
----
A
E
P
V
-
M
G
A
-
G
-
G
V
I
P
P
A
K
G
Y
F
Q
A
I
L
P
I
L
R
K
Y
D
I
P
V
I
S
D
E
V
V
C
G
F
G
R
T
G
N
T
W
G
C
V
-
T
-
Y
D
F
T
--
P
D
A
I
I
S
S
K
N
L
T
A
G
-
F
F
P
M
G
A
V
I
L
G
P
E
L
S
K
R
-
L
-
E
-
T
A
-
I
E
A
I
E
E
F
P
H
G
F
T
A
S
G
H
P
V
G
C
A
I
A
L
K
A
I
D
V
V
M
N
E
G
L
A
E
N
V
R
-
R
L
A
P
---
R
F
E
E
R
-
L
-
K
H
I
-
A
-
E
R
-
P
N
I
-
G
E
Y
R
G
I
G
F
M
W
A
L
E
A
V
K
D
K
A
S
K
T
--
P
--
F
--
D
--
G
NL
S
-
V
S
E
-
R
I
A
N
T
C
T
D
L
----
G
L
I
---
C
F
P
L
G
Q
S
V
V
-------
L
C
P
P
F
I
L
T
----
E
A
Q
M
D
E
M
F
D
K
L
E
K
A
L
D
K
V
-----
6
PsiBlast_PDB
54.32
31%
-99
- C1 -
3NUI
-
?
A:
[30-448]
-----------------------------------------------------
T
--
V
V
V
T
H
G
E
G
P
Y
I
V
D
V
-
N
G
--
R
R
Y
L
D
A
N
S
G
L
W
-
N
M
V
A
G
F
D
H
K
G
L
I
D
A
A
K
A
Q
Y
E
R
F
P
G
-
Y
--
H
A
F
F
-
G
--
R
----
M
S
D
--
Q
--
T
V
M
L
S
E
K
-
L
-
V
E
V
S
P
F
D
--
S
G
R
-
V
F
Y
T
N
S
G
S
E
A
N
D
T
M
V
K
M
L
W
F
L
H
A
A
E
G
K
P
Q
-
K
R
K
I
L
T
R
W
N
A
Y
H
G
V
T
A
V
S
A
S
M
T
G
K
P
Y
-
N
S
V
F
-
G
L
----
P
L
P
----
G
F
V
H
L
T
-
C
P
H
Y
W
R
----
Y
G
------
E
--
E
-----
G
E
T
-----
E
E
Q
F
V
A
R
L
A
R
E
L
--
E
-----
E
T
I
Q
R
E
G
A
D
T
----
I
A
G
F
F
----
A
E
P
V
-
M
G
A
-
G
-
G
V
I
P
P
A
K
G
Y
F
Q
A
I
L
P
I
L
R
K
Y
D
I
P
V
I
S
D
E
V
I
C
G
F
G
R
T
G
N
T
W
G
C
V
-
T
-
Y
D
F
T
--
P
D
A
I
I
S
S
K
N
L
T
A
G
-
F
F
P
M
G
A
V
I
L
G
P
E
L
S
K
R
-
L
-
E
-
T
A
I
E
-
A
I
E
E
F
P
H
G
F
T
A
S
G
H
P
V
G
C
A
I
A
L
K
A
I
D
V
V
M
N
E
G
L
A
E
N
V
R
-
R
L
A
P
---
R
F
E
E
R
-
L
-
K
H
I
-
A
-
E
R
-
P
N
I
-
G
E
Y
R
G
I
G
F
M
W
A
L
E
A
V
K
D
K
A
S
K
T
--
P
--
F
--
D
--
G
NL
S
-
V
S
E
-
R
I
A
N
T
C
T
D
L
----
G
L
I
---
C
R
P
L
G
Q
S
V
V
-------
L
C
P
P
F
I
L
T
----
E
A
Q
M
D
E
M
F
D
K
L
E
K
A
L
D
K
V
-----
16
PsiBlast_PDB
53.85
33%
-107
- C1 -
3DRD
-
BIOK_BACSU
A:
[5-443]
--------------
L
I
E
K
S
K
K
H
L
W
L
-----
P
---
F
T
Q
M
---
K
---
D
----
Y
D
-
E
N
P
L
I
I
E
S
G
T
G
I
K
V
K
D
I
-
N
G
--
K
E
Y
Y
D
G
F
S
S
V
W
-
L
N
V
H
G
H
R
K
K
E
L
D
D
A
I
K
K
Q
L
G
K
I
A
H
-
S
--
T
--
L
-
L
G-
M
----
T
N
V
--
P
--
A
T
Q
L
A
E
T
-
L
-
I
D
I
S
P
K
K
--
L
-
T
R
V
F
Y
S
D
S
G
A
E
A
M
E
I
A
L
K
M
A
F
Q
Y
W
K
N
I
G
K
P
E
-
K
Q
K
F
I
A
M
K
--------------------------------------
S
Y
K
A
P
-
I
P
Y
V
Y
R
SESG
D
P
------
D
--
E
-----
C
R
D
------
Q
C
-----
L
R
E
L
--
A
-----
Q
L
L
E
-
E
H
H
E
E
----
I
A
A
L
S
----
I
E
S
M
-
V
Q
G
-
A
S
G
M
I
V
M
P
E
G
Y
L
A
G
V
R
E
L
C
T
T
Y
D
V
L
M
I
V
D
E
V
A
T
G
F
G
R
T
G
K
M
F
A
C
E
-
H
-
E
N
V
Q
--
P
D
L
M
A
A
G
K
G
I
T
G
G
-
Y
L
P
I
A
V
T
F
A
T
E
D
I
Y
K
A
F
Y
-
D
-
D
Y
-
E
-
N
L
K
T
F
F
H
G
H
S
Y
T
G
N
Q
L
G
C
A
V
A
L
E
N
L
A
L
F
E
S
E
N
I
V
E
Q
V
A
-
E
K
S
K
---
K
L
H
F
L
-
L
-
Q
D
L
-
H
-
A
L
-
P
H
V
-
G
D
I
R
Q
L
G
F
M
C
G
A
E
L
V
R
S
K
E
T
K
E
PY
P
--
A
--
D
--
R
--
R
-
I
G
Y
-
K
V
S
L
K
M
R
E
L
----
G
M
L
---
T
R
P
L
G
D
-------
V
I
A
F
L
P
P
L
A
S
T
----
A
E
E
L
S
E
M
V
A
I
M
K
Q
A
I
H
E
V
-----
5
PsiBlast_PDB
53.80
31%
-103
- C1 -
4GRX
2
?
A:
[17-460]
------------
Q
S
W
E
A
R
A
E
T
Y
S
L
Y
-----
G
FTD
M
P
S
V
---
H
---
Q
----
R
G
-
T
--
V
V
V
T
H
G
E
G
P
Y
I
V
D
V
-
H
G
--
R
R
Y
L
D
A
N
S
G
L
W
-
N
M
V
A
G
F
D
H
K
G
L
I
E
A
A
K
A
Q
Y
D
R
F
P
G
-
Y
--
H
AF
F
-
G
--
R
----
M
S
D
--
Q
--
T
V
M
L
S
E
K
-
L
-
V
E
V
S
P
F
D
--
N
G
R
-
V
F
Y
T
N
S
G
S
E
A
N
D
T
M
V
K
M
L
W
F
L
H
A
A
E
G
K
P
Q
-
K
R
K
I
L
T
R
W
N
A
Y
H
G
V
T
A
V
S
A
S
M
T
G
K
P
Y
-
N
S
V
F
-
G
L
----
P
L
P
----
G
F
I
H
L
T
-
C
P
H
Y
W
R
----
Y
G
------
E
--
E
-----
G
E
T
E
A
Q
F
V
A
R
L
-----
A
R
E
L
--
E
-----
D
T
I
T
R
E
G
A
D
T
----
I
A
G
F
F
----
A
E
P
V
-
M
G
A
-
G
-
G
V
I
P
P
A
K
G
Y
F
Q
A
I
L
P
I
L
R
K
Y
D
I
P
M
I
S
D
E
V
I
C
G
F
G
R
T
G
N
T
W
G
C
L
-
T
-
Y
D
F
M
--
P
D
A
I
I
S
S
K
N
L
T
A
G
-
F
F
P
M
G
A
V
I
L
G
P
D
L
A
K
R
-
V
-
E
-
A
A
-
V
E
A
I
E
E
F
P
H
G
F
T
A
S
G
H
P
V
G
C
A
I
A
L
K
A
I
D
V
V
M
N
E
G
L
A
E
N
V
R
-
R
L
A
P
---
R
F
E
A
G
-
L
-
K
R
I
-
A
-
D
R
-
P
N
I
-
G
E
Y
R
G
I
G
F
M
W
A
L
E
A
V
K
D
K
P
T
K
T
--
P
--
F
--
D
--
A
NL
S
-
V
S
E
-
R
I
A
N
T
C
T
D
L
----
G
L
I
---
C
R
P
L
G
Q
S
I
V
-------
L
C
P
P
F
I
L
T
----
E
A
Q
M
D
E
M
F
E
K
L
E
K
A
L
D
K
V
-----
21
PsiBlast_CBE
53.32
36%
-102
- C1 -
3HMU
3
?
B:
[40-449]
---------------------------------------------------------
V
I
T
R
A
R
G
V
W
L
N
D
S
-
E
G
--
E
E
I
L
D
A
M
A
G
L
W
-
C
V
N
I
G
Y
G
R
D
E
L
A
E
V
A
A
R
Q
M
R
E
L
P
Y
-
Y
--
N
TF
F
-
K
--
T
----
T
H
V
--
P
--
A
I
A
L
A
Q
K
-
L
-
A
E
L
A
P
G
D
--
L
-
N
H
V
F
F
A
G
G
G
S
E
A
N
D
T
N
I
R
M
V
R
T
Y
W
Q
N
K
G
Q
P
E
-
K
T
V
I
I
S
R
K
N
A
Y
H
G
S
T
V
-
A
S
S
A
L
G
G
M
A
-
G
M
H
A
-
Q
S
----
G
L
I
P
---
D
V
H
H
I
N
-
Q
P
N
W
W
A
----
E
G
------
G
--
D
-----
M
D
P
EEFG-
L
A
R
-----
A
R
E
L
--
E
-----
E
A
I
L
-
E
L
G
E
N
R---
V
A
A
F
I
----
A
E
P
V
-
Q
G
A
-
G
-
G
V
I
V
A
P
D
S
Y
W
P
E
I
Q
R
I
C
D
K
Y
D
I
L
L
I
A
D
E
V
I
C
G
F
G
R
T
G
N
W
F
G
T
Q
-
T
-
M
G
I
R
--
P
H
I
M
T
I
A
K
G
L
S
S
G
-
Y
A
P
I
G
G
S
I
V
C
D
E
V
A
H
V
-
I
-
G
-------
K
D
E
F
N
H
G
Y
T
Y
S
G
H
P
V
A
A
A
V
A
L
E
N
L
R
I
L
E
E
E
N
I
L
D
H
V
R
-
N
V
A
A
---
P
Y
L
K
E
K
W
-
E
A
L
-
T
-
D
H
-
P
L
V
-
G
E
A
K
I
V
G
M
M
A
S
I
A
L
T
P
N
K
A
S
R
A
--
K
--
F
-----
A
--
S
-
E
P
G
-
T
I
G
Y
I
C
R
E
R
CFAN
N
L
I
---
M
R
H
V
G
D
R
M
I
-------
I
S
P
P
L
V
I
T
----
P
A
E
I
D
E
M
F
V
R
I
R
K
S
L
--------
33
PsiBlast_CBE
53.26
33%
-110
- C1 -
3DOD
2
BIOK_BACSU
B:
[5-443]
--------------
L
I
E
K
S
K
K
H
L
W
L
-----
P
---
F
T
Q
M
---
K
---
D
----
Y
D
-
E
N
P
L
I
I
E
S
G
T
G
I
K
V
K
D
I
-
N
G
--
K
E
Y
Y
D
G
F
S
S
V
W
-
L
N
V
H
G
H
R
K
K
E
L
D
D
A
I
K
K
Q
L
G
K
I
A
H
-
S
--
T
--
L
-
L
G-
M
----
T
N
V
--
P
--
A
T
Q
L
A
E
T
-
L
-
I
D
I
S
P
K
K
--
L
-
T
R
V
F
Y
S
D
S
G
A
E
A
M
E
I
A
L
K
M
A
F
Q
Y
W
K
N
I
G
K
P
E
-
K
Q
K
F
I
A
M
K
--------------------------------------
S
Y
K
A
P
-
I
P
Y
V
Y
R
SESG
D
P
------
D
--
E
-----
C
R
D
------
Q
C
-----
L
R
E
L
--
A
-----
Q
L
L
E
-
E
H
H
E
E
----
I
A
A
L
S
----
I
E
S
M
-
V
Q
G
-
A
S
G
M
I
V
M
P
E
G
Y
L
A
G
V
R
E
L
C
T
T
Y
D
V
L
M
I
V
D
E
V
A
T
G
F
G
R
T
G
K
M
F
A
C
E
-
H
-
E
N
V
Q
--
P
D
L
M
A
A
G
K
G
I
T
G
G
-
Y
L
P
I
A
V
T
F
A
T
E
D
I
Y
K
A
F
Y
-
D
-
D
Y
-
E
-
N
L
K
T
F
F
H
G
H
S
Y
T
G
N
Q
L
G
C
A
V
A
L
E
N
L
A
L
F
E
S
E
N
I
V
E
Q
V
A
-
E
K
S
K
---
K
L
H
F
L
-
L
-
Q
D
L
-
H
-
A
L
-
P
H
V
-
G
D
I
R
Q
L
G
F
M
C
G
A
E
L
V
R
S
K
E
T
K
E
PY
P
--
A
--
D
--
R
--
R
-
I
G
Y
-
K
V
S
L
K
M
R
E
L
----
G
M
L
---
T
R
P
L
G
D
-------
V
I
A
F
L
P
P
L
A
S
T
----
A
E
E
L
S
E
M
V
A
I
M
K
Q
A
I
H
E
V
-----
124
Fugue
51.98
30%
-111
- C1 -
1DTY
5
BIOA_ECOLI
A:
[1-429]
----------
M
T
T
D
D
L
A
F
D
E
R
H
I
W
H
-----
P
---
Y
T
S
M
---
T
---
S
----
P
L
P
V
--
Y
P
V
V
S
A
E
G
C
E
L
I
L
S
-
D
G
--
R
R
L
V
D
G
M
S
S
W
W
-
A
A
I
H
G
Y
N
H
P
Q
L
N
A
A
M
K
-
S
Q
I
D
A
M
-----
S
--
H
-
V
--
M
FGEI
T
H
A
--
P
--
A
I
E
L
C
R
K
-
L
-
V
A
M
T
P
Q
P
--
L
E
C
-
V
F
L
A
D
S
G
S
V
A
V
E
V
A
M
K
M
A
L
Q
Y
W
D
A
K
-
G
E
-A
R
D
R
F
L
T
F
R
N
G
Y
H
G
D
T
F
G
A
M
S
V
C
D
P
D
N
-
S
M
H
S
L
W
K
----
G
Y
L
P
---
E
N
L
F
A
P
-
A
P
Q
S
R
M
----
D
G
------
E
WD------
E
R
D
-----
M
V
G
-----
F
A
R
L
--
M
-----
A
A
H
R
H
----
E
----
I
A
A
V
I
----
I
E
P
I
-
V
Q
G
A
G
-
G
M
R
M
Y
H
P
E
W
L
K
R
I
R
K
I
C
D
R
E
G
I
L
L
I
A
D
E
I
A
T
G
F
G
R
T
G
K
L
F
A
C
E
-
H
-
A
E
--IA
P
D
I
L
C
L
G
K
A
L
T
G
G
-
T
M
T
L
S
A
T
L
T
T
R
E
V
A
E
T
-
I
-
S
-
D
G
-
E
-
A
-
G
C
F
M
H
G
P
T
F
M
G
N
P
L
A
C
A
A
A
N
A
S
L
A
I
L
E
S
G
D
W
Q
Q
Q
V
A
-
D
I
E
V
---
Q
L
R
E
Q
-
L
-
A
P
A
-
R
-
D
-A
E
M
V
-
A
D
V
R
V
L
G
A
I
G
V
V
E
T
T
-----
H
P
--
V
-----
N
--------
M
A
-
A
L
Q
K
F
F
V
E
Q
----
G
V
W
---
I
R
P
F
-------
G
K
L
I
Y
L
M
P
P
Y
I
I
L
----
P
Q
Q
L
Q
R
L
T
A
A
V
N
R
A
V
Q
D
E
TFFCQ
3
PsiBlast_PDB
51.85
34%
-85
- C1 -
3FCR
5
?
A:
[4-456]
----------
K
N
D
Q
L
D
Q
W
D
R
D
N
F
F
H
PSTH
L
A
---
Q
H
A
R
---
G
---
E
----
S
A
-
N
--
R
V
I
K
T
A
S
G
V
F
I
E
D
R
-
D
G
--
T
K
L
L
D
A
F
A
G
L
Y
-
C
V
N
V
G
Y
G
R
Q
E
I
A
E
A
I
A
D
Q
A
R
E
L
A
Y
-
Y
--
H
--
S
-
Y
--
V
----
G
H
G
--
T
E
A
S
I
T
L
A
K
M
I
L
-
D
R
A
P
K
N
M
--
S
-
K
-
V
Y
F
G
L
G
G
S
D
A
N
E
T
N
V
K
L
I
W
Y
Y
N
N
I
L
G
R
P
E
-
K
K
K
I
I
S
R
W
R
G
Y
H
G
S
G
L
V
T
G
S
L
T
G
L
E
L
-
F
H
K
K
-
F
D
----
L
P
V
E
---
Q
V
I
H
T
E
-
A
P
Y
Y
F
R
----
R
E
------
D
--
L
-----
N
Q
T
-----
E
E
Q
F
V
A
H
C
V
A
E
L
--
E
-----
A
L
I
E
R
E
G
A
D
T
----
I
A
A
F
I
----
G
E
P
I
-
L
G
T
-
G
-
G
I
V
P
P
P
A
G
Y
W
E
A
I
Q
T
V
L
N
K
H
D
I
L
L
V
A
D
E
V
V
T
G
F
G
R
L
G
T
M
F
G
S
D
-
H
-
Y
G
L
E
--
P
D
I
I
T
I
A
K
G
L
T
S
A
-
Y
A
P
L
S
G
S
I
V
S
D
K
V
W
K
V
-
L
E
Q
-
G
T
-
D
-
E
N
G
P
I
G
H
G
W
T
Y
S
A
H
P
I
G
A
A
A
G
V
A
N
L
K
L
L
D
E
L
N
L
V
S
N
A
G
-
E
V
G
A
---
Y
L
N
A
T
-
M
A
E
A
L
-
S
-
Q
H
-
A
N
V
-
G
D
V
R
G
E
G
L
L
C
A
V
E
F
V
K
D
R
D
S
R
T
--
F
--
F
--
D
--
A
--
A
D
K
I
G
P
Q
I
S
A
K
L
L
E
Q
----
D
K
I
---
I
A
R
----
A
M
P
Q
G
D
I
L
G
F
A
P
P
F
C
L
T
----
R
A
E
A
D
Q
V
V
E
G
T
L
R
A
V
K
A
V
-----
101
HHSearch
51.83
32%
-99
- C1 -
4E3Q
6
?
A:
[24-467]
-----------
P
Q
S
W
E
A
R
A
E
T
Y
S
L
Y
-----
G
---
F
T
D
M
P
S
L
H
---
Q
----
R
G
-
T
--
V
V
V
T
H
G
E
G
P
Y
I
V
D
V
-
N
G
--
R
R
Y
L
D
A
N
S
G
L
W
-
N
M
V
A
G
F
D
H
K
G
L
I
D
A
A
K
A
Q
Y
E
R
F
P
G
-
Y
--
H
--
A
-
F
FG
R
----
M
S
D
--
Q
--
T
V
M
L
S
E
K
-
L
-
V
E
V
S
P
F
D
S
-
G
-
R
-
V
F
Y
T
N
S
G
S
E
A
N
D
T
M
V
K
M
L
W
F
L
H
A
A
E
G
K
P
Q
-
K
R
K
I
L
T
R
W
N
A
Y
H
G
V
T
A
V
S
A
S
M
T
G
K
P
--
Y
N
S
V
-
F
G
----
L
P
L
P
---
G
F
V
H
L
T
-
C
P
H
Y
W
R
----
Y
G
------
E
--
E
-----
G
E
T
E
E
Q
F
V
A
R
L
-----
A
R
E
L
--
E
-----
E
T
I
Q
R
E
G
A
D
T
----
I
A
G
F
F
----
A
E
P
V
-
M
G
A
-
G
-
G
V
I
P
P
A
K
G
Y
F
Q
A
I
L
P
I
L
R
K
Y
D
I
P
V
I
S
D
E
V
I
C
G
F
G
R
T
G
N
T
W
G
C
V
-
T
-
Y
D
F
T
--
P
D
A
I
I
S
S
K
N
L
T
A
G
F
F
-
P
M
G
A
V
I
L
G
P
E
L
S
K
R
-
L
-
E
-
T
A
-
I
E
A
I
E
E
F
P
H
G
F
T
A
S
G
H
P
V
G
C
A
I
A
L
K
A
I
D
V
V
M
N
E
G
L
A
E
N
V
R
-
R
L
A
P
---
R
F
E
E
R
-
L
-
K
H
I
-
A
-
E
R
-
P
N
I
-
G
E
Y
R
G
I
G
F
M
W
A
L
E
A
V
K
D
K
A
S
K
T
--
P
--
F
--
D
--
G
NL
S
-
V
S
E
-
R
I
A
N
T
C
T
D
L
----
G
L
I
---
C
R
P
L
G
-------
Q
S
V
V
L
C
P
P
F
I
L
T
----
E
A
Q
M
D
E
M
F
D
K
L
E
K
A
L
D
K
------
4
PsiBlast_PDB
49.94
33%
-87
- C1 -
3GJU
2
?
A:
[3-456]
--------
L
N
Q
S
N
E
L
N
A
W
D
R
D
H
F
F
H
PS---
T
---
H
M
G
T
---
H
A
R
G
E
----
S
P
-
T
--
R
I
M
A
G
G
E
G
V
T
V
W
D
N
-
N
G
--
R
K
S
I
D
A
F
A
G
L
Y
-
C
V
N
V
G
Y
G
R
Q
K
I
A
D
A
I
A
T
Q
A
K
N
L
A
Y
-
Y
--
H
--
A
-
Y
--
V
----
G
H
G
T
E
A
--
S
I
T
L
A
K
M
-
I
I
D
R
A
P
K
G
M
--
S
-
R
-
V
Y
F
G
L
S
G
S
D
A
N
E
T
N
I
K
L
I
W
Y
Y
N
N
V
L
G
R
P
E
-
K
K
K
I
I
S
R
W
R
G
Y
H
G
S
G
V
M
T
G
S
L
T
G
L
D
L
-
F
H
N
A
-
F
D
----
L
P
R
A
---
P
V
L
H
T
E
-
A
P
Y
Y
F
R
----
R
T
------
D
--
R
-----
S
M
S
-----
E
E
Q
F
S
Q
H
C
A
D
K
L
--
E
-----
E
M
I
L
A
E
G
P
E
T
----
I
A
A
F
I
----
G
E
P
I
-
L
G
T
-
G
-
G
I
V
P
P
P
A
G
Y
W
E
K
I
Q
A
V
L
K
K
Y
D
V
L
L
V
A
D
E
V
V
T
G
F
G
R
L
G
T
M
F
G
S
D
-
H
-
Y
G
I
K
--
P
D
L
I
T
I
A
K
G
L
T
S
A
-
Y
A
P
L
S
G
V
I
V
A
D
R
V
W
Q
V
L
V
-
Q
-
G
S
-
D
-
K
L
G
S
L
G
H
G
W
T
Y
S
A
H
P
I
C
V
A
A
G
V
A
N
L
E
L
I
D
E
M
D
L
V
T
N
A
G
-
E
T
G
A
---
Y
F
R
A
E
-
L
A
K
A
V
-
G
-
G
H
-
K
N
V
-
G
E
V
R
G
D
G
M
L
A
A
V
E
F
V
A
D
K
D
D
R
V
--
F
--
F
--
D
--
A
--
S
Q
K
I
G
-
P
Q
V
A
T
A
L
A
A
----
S
G
V
---
I
G
R
----
A
M
P
Q
G
D
I
L
G
F
A
P
P
L
C
L
T
----
R
E
Q
A
D
I
V
V
S
K
T
A
D
A
V
K
S
V
-----
108
HHSearch
49.74
29%
-119
- C1 -
4WYD
13
BIOA_MYCTU
A:
[28-452]
--------
L
T
P
E
Q
-
I
I
A
V
D
G
A
H
L
W
H
-----
P
---
Y
S
S
I
---
G
RE-
A
----
V
S
-
P
--
V
V
A
V
A
A
H
G
A
W
L
T
L
I
R
D
G
Q
P
I
E
V
L
D
A
M
S
S
W
W
-
T
A
I
H
G
H
G
H
P
A
L
D
Q
A
L
T
T
Q
L
R
V
M
N
H
-
V
--
M
--
F
G
G
--
L
----
T
H
E
--
P
--
A
A
R
L
A
K
L
-
L
-
V
D
I
T
P
A
G
L-
D
-
T
-
V
F
F
S
D
S
G
S
V
S
V
E
V
A
A
K
M
A
L
Q
Y
W
R
G
R
G
L
P
G
-
K
R
R
L
M
T
W
R
G
G
Y
H
G
D
T
F
L
A
M
S
I
C
D
P
H
G
G
M
H
S
L
-
W
T
----
D
V
L
A
---
A
Q
V
F
A
P
Q
V
P
R
D
Y
D
----
P
-------------------------
A
Y
-----
S
A
A
F
--
E
-----
A
Q
L
A
Q
-
H
A
G
E
----
L
A
A
V
V
----
V
E
P
V
V
Q
G
A
-
G
-
G
M
R
F
H
D
P
R
Y
L
H
D
L
R
D
I
C
R
R
Y
E
V
L
L
I
F
D
E
I
A
T
G
F
G
R
T
G
A
L
F
A
A
D
-
H
-
A
G
V
S
--
P
D
I
M
C
V
G
K
A
L
T
G
G
-
Y
L
S
L
A
A
T
L
C
T
A
D
V
A
H
T
-
I
-
S
-
A
G
-
A
--
A
G
A
L
M
H
G
P
T
F
M
A
N
P
L
A
C
A
V
S
V
A
S
V
E
L
L
L
G
Q
D
W
R
T
R
I
T
-
E
L
A
A
---
G
L
T
A
G
-
L
-
D
T
A
-
R
-
A
L
-
P
A
V
-
T
D
V
R
V
C
G
A
I
G
V
I
E
C
D
R
P
V
D
--------------------
L
A
-
V
A
T
P
A
A
L
D
R
----
G
V
W
---
L
R
P
F
R
-------
N
L
V
Y
A
M
P
P
Y
I
C
T
----
P
A
E
I
T
Q
I
T
S
A
M
V
E
V
A
R
L
------
103
HHSearch
49.62
33%
-88
- C1 -
3GJU
2
?
A:
[6-455]
-----------
S
N
E
L
N
A
W
D
R
D
H
F
F
H
-----
P
---
S
T
H
M
---
G
T
--
H
A
R
GE
S
P
-
T
--
R
I
M
A
G
G
E
G
V
T
V
W
D
N
-
N
G
--
R
K
S
I
D
A
F
A
G
L
Y
-
C
V
N
V
G
Y
G
R
Q
K
I
A
D
A
I
A
T
Q
A
K
N
L
A
Y
-
Y
--
H
--
A
-
Y
VG
H
----
G
T
E
--
A
--
S
I
T
L
A
K
M
-
I
-
I
D
R
A
P
K
G
M-
S
-
R
-
V
Y
F
G
L
S
G
S
D
A
N
E
T
N
I
K
L
I
W
Y
Y
N
N
V
L
G
R
P
E
-
K
K
K
I
I
S
R
W
R
G
Y
H
G
S
G
V
M
T
G
S
L
T
G
L
D
L
-
F
H
N
A
-
F
D
----
L
P
R
A
---
P
V
L
H
T
E
-
A
P
Y
Y
F
R
----
R
T
------
D
--
R
SMS
E
E
Q
F
S
-----
Q
H
C
-----
A
D
K
L
--
E
-----
E
M
I
L
A
E
G
P
E
T
----
I
A
A
F
I
----
G
E
P
I
-
L
G
T
-
G
-
G
I
V
P
P
P
A
G
Y
W
E
K
I
Q
A
V
L
K
K
Y
D
V
L
L
V
A
D
E
V
V
T
G
F
G
R
L
G
T
M
F
G
S
D
-
H
-
Y
G
I
K
--
P
D
L
I
T
I
A
K
G
L
T
S
A
-
Y
A
P
L
S
G
V
I
V
A
D
R
V
W
Q
V
-
L
-
V
-
Q
G
-
S
D
K
L
G
S
L
G
H
G
W
T
Y
S
A
H
P
I
C
V
A
A
G
V
A
N
L
E
L
I
D
E
M
D
L
V
T
N
A
G
-
E
T
G
A
---
Y
F
R
A
E
-
L
-
A
K
A
-
V
G
G
H
-
K
N
V
-
G
E
V
R
G
D
G
M
L
A
A
V
E
F
V
A
D
K
D
D
R
V
--
F
FD
A
--
S
--
Q
--
K
-
I
G
P
-
Q
V
A
T
A
L
A
A
S
----
G
V
I
---
G
R
A
M
P
-----
Q
G
D
I
L
G
F
A
P
P
L
C
L
T
----
R
E
Q
A
D
I
V
V
S
K
T
A
D
A
V
K
S
------
23
PsiBlast_CBE
49.56
34%
-105
- C1 -
4BA4
1
?
B:
[33-453]
-----------------------------------------------------
A
--
R
V
M
T
R
G
E
G
V
Y
L
W
D
S
-
E
G
--
N
K
I
I
D
G
M
A
G
L
W
-
C
V
N
V
G
Y
G
R
K
D
F
A
E
A
A
R
R
Q
M
E
E
L
P
F
-
Y
--
N
TF
F
-
K
--
T
----
T
H
P
--
A
--
V
V
E
L
S
S
L
-
L
-
A
E
V
T
P
A
G
--
F
D
R
-
V
F
Y
T
N
S
G
S
E
S
V
D
T
M
I
R
M
V
R
R
Y
W
D
V
Q
G
K
P
E
-
K
K
T
L
I
G
R
W
N
G
Y
H
G
S
T
I
G
G
A
S
L
G
G
M
----
K
Y
M
-
H
E
QGDL
P
I
P
----
G
M
A
H
I
E
-
Q
P
W
W
Y
K
----
H
G
------
K
--
D
-----
M
T
P
-----
D
E
F
-----
G
V
V
A
--
A
-----
R
W
L
E
E
K
I
L
E
I
GADK
V
A
A
F
V
----
G
E
P
I
-
Q
G
A
-
G
-
G
V
I
V
P
P
A
T
Y
W
P
E
I
E
R
I
C
R
K
Y
D
V
L
L
V
A
D
E
V
I
C
G
F
G
R
T
G
E
W
F
G
H
Q
-
H
-
F
G
F
Q
--
P
D
L
F
T
A
A
K
G
L
S
S
G
-
Y
L
P
I
G
A
V
F
V
G
K
R
V
A
E
------
G
L
-
I
-
A
G
G
D
F
N
H
G
F
T
Y
S
G
H
P
V
C
A
A
V
A
H
A
N
V
A
A
L
R
D
E
G
I
V
Q
R
V
K
D
D
I
G
P
YMQ
K
R
W
R
E
-
T
-
F
S
R
-
F
-
E
H
---
V
-
D
D
V
R
G
V
G
M
V
Q
A
F
T
L
V
K
N
K
A
K
R
E
--
L
--------
F
--
P
-
D
F
G
-
E
I
G
T
L
C
R
D
-------
I
---
F
F
R
N
N
L
I
M
R
A
C
G
D
H
I
V
S
A
P
P
L
V
M
T
RAEV
D
E
M
L
A
V
A
E
R
C
L
E
E
F
E
Q
T
L
-----
2
PsiBlast_PDB
49.52
36%
-101
- C1 -
3HMU
3
?
A:
[40-449]
---------------------------------------------------------
V
I
T
R
A
R
G
V
W
L
N
D
S
-
E
G
--
E
E
I
L
D
A
M
A
G
L
W
-
C
V
N
I
G
Y
G
R
D
E
L
A
E
V
A
A
R
Q
M
R
E
L
P
Y
-
Y
--
N
TF
F
-
K
--
T
----
T
H
V
--
P
--
A
I
A
L
A
Q
K
-
L
-
A
E
L
A
P
G
D
--
L
-
N
H
V
F
F
A
G
G
G
S
E
A
N
D
T
N
I
R
M
V
R
T
Y
W
Q
N
K
G
Q
P
E
-
K
T
V
I
I
S
R
K
N
A
Y
H
G
S
T
V
-
A
S
S
A
L
G
G
M
A
-
G
M
H
A
-
Q
S
----
G
L
I
P
---
D
V
H
H
I
N
-
Q
P
N
W
W
A
----
E
G
------
G
--
D
-----
M
D
P
E
E
F
G
-
L
A
R
-----
A
R
E
L
--
E
-----
E
A
I
L
-
E
L
G
E
N
R---
V
A
A
F
I
----
A
E
P
V
-
Q
G
A
-
G
-
G
V
I
V
A
P
D
S
Y
W
P
E
I
Q
R
I
C
D
K
Y
D
I
L
L
I
A
D
E
V
I
C
G
F
G
R
T
G
N
W
F
G
T
Q
-
T
-
M
G
I
R
--
P
H
I
M
T
I
A
K
G
L
S
S
G
-
Y
A
P
I
G
G
S
I
V
C
D
E
V
A
H
V
-
I
-
G
-------
K
D
E
F
N
H
G
Y
T
Y
S
G
H
P
V
A
A
A
V
A
L
E
N
L
R
I
L
E
E
E
N
I
L
D
H
V
R
-
N
V
A
A
---
P
Y
L
K
E
K
W
-
E
A
L
-
T
-
D
H
-
P
L
V
-
G
E
A
K
I
V
G
M
M
A
S
I
A
L
T
P
N
K
A
S
R
A
--
K
--
F
-----
A
--
S
-
E
P
G
-
T
I
G
Y
I
C
R
E
R
C
F
A
N
N
L
I
---
M
R
H
V
G
D
R
M
I
-------
I
S
P
P
L
V
I
T
----
P
A
E
I
D
E
M
F
V
R
I
R
K
S
L
--------
111
HHSearch
49.24
31%
-105
- C1 -
4JF1
9
ARGD_SALTY
A:
[38-417]
--------------------------------------------------
P
A
-
D
--
F
I
P
V
K
G
K
G
S
R
V
W
D
Q
-
Q
G
--
K
E
Y
I
D
F
A
G
G
I
A
-
V
T
A
L
G
H
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
-
T
--
S
--
N
-
V
--
F
----
T
N
E
--
P
--
A
L
R
L
G
R
K
-
L
-
I
D
A
T
F
A
---
E
-
R
-
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
H
S
P
F
-
K
T
K
I
I
A
F
H
N
A
F
H
G
Q
S
L
F
T
V
S
V
G
G
Q
P
K
-
Y
S
D
G
-
F
G
----
P
K
P
A
---
D
I
I
H
V
P
-
F
N
-----------------------------------
D
-----
L
H
A
V
--
K
-----
A
V
M
D
----
D
H
----
T
C
A
V
V
----
V
E
P
I
-
Q
G
E
-
G
-
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
-
H
-
Y
G
V
T
--
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
-
F
----------------
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
-
T
K
R
Q
---
Q
F
V
Q
H
-
L
-
Q
A
I
-
D
E
Q
F
-
D
I
F
-
S
D
I
R
G
M
G
L
L
I
G
A
E
L
K
P
K
Y
K
-----------------
G
-
R
A
R
-
D
F
L
Y
A
G
A
E
A
----
G
V
M
---
V
L
N
A
G
------
A
D
V
M
R
F
A
P
S
L
V
V
E
----
E
A
D
I
H
E
G
M
Q
R
F
A
Q
A
V
G
K
------
26
PsiBlast_CBE
49.23
34%
-104
- C1 -
4AH3
2
?
B:
[29-453]
-----------------------------------------
N
---
Q
----
A
G
-
A
--
R
V
M
T
R
G
E
G
V
Y
L
W
D
S
-
E
G
--
N
K
I
I
D
G
M
A
G
L
W
-
C
V
N
V
G
Y
G
R
K
D
F
A
E
A
A
R
R
Q
M
E
E
L
P
F
-
Y
--
N
TF
F
-
K
--
T
----
T
H
P
--
A
--
V
V
E
L
S
S
L
-
L
-
A
E
V
T
P
A
G
--
F
D
R
-
V
F
Y
T
N
S
G
S
E
S
V
D
T
M
I
R
M
V
R
R
Y
W
D
V
Q
G
K
P
E
-
K
K
T
L
I
G
R
W
N
G
Y
H
G
S
T
I
G
G
A
S
L
G
G
M
----
K
Y
M
-
H
E
QGDL
P
I
P
----
G
M
A
H
I
E
-
Q
P
W
W
Y
K
----
H
G
------
K
--
D
-----
M
T
P
-----
D
E
F
-----
G
V
V
A
--
A
-----
R
W
L
E
E
K
I
L
E
I
GADK
V
A
A
F
V
----
G
E
P
I
-
Q
G
A
-
G
-
G
V
I
V
P
P
A
T
Y
W
P
E
I
E
R
I
C
R
K
Y
D
V
L
L
V
A
D
E
V
I
C
G
F
G
R
T
G
E
W
F
G
H
Q
-
H
-
F
G
F
Q
--
P
D
L
F
T
A
A
K
G
L
S
S
G
-
Y
L
P
I
G
A
V
F
V
G
K
R
V
A
E
------
G
L
-
I
-
A
G
G
D
F
N
H
G
F
T
Y
S
G
H
P
V
C
A
A
V
A
H
A
N
V
A
A
L
R
D
E
G
I
V
Q
R
V
K
D
D
I
G
P
YMQ
K
R
W
R
E
-
T
-
F
S
R
-
F
-
E
H
---
V
-
D
D
V
R
G
V
G
M
V
Q
A
F
T
L
V
K
N
K
A
K
R
E
--
L
--------
F
--
P
-
D
F
G
-
E
I
G
T
L
C
R
D
-------
I
---
F
F
R
N
N
L
I
M
R
A
C
G
D
H
I
V
S
A
P
P
L
V
M
T
RAEV
D
E
M
L
A
V
A
E
R
C
L
E
E
F
E
Q
T
L
-----
106
HHSearch
48.47
30%
-102
- C1 -
3I5T
2
?
A:
[13-453]
-------------
A
V
G
A
A
M
R
D
H
I
L
L
-----
P
---
A
Q
E
M
AK-
L
G--
K
----
S
A
-
Q
--
P
V
L
T
H
A
E
G
I
Y
V
H
T
E
-
D
G
--
R
R
L
I
D
G
P
A
G
M
W
-
C
A
Q
V
G
Y
G
R
R
E
I
V
D
A
M
A
H
Q
A
M
V
L
P
Y
-
A
--
S
--
P
-
W
Y-
M
----
A
T
S
--
P
--
A
A
R
L
A
E
K
-
I
-
A
T
L
T
P
G
D
L-
N
-
R
-
I
F
F
T
T
G
G
S
T
A
V
D
S
A
L
R
F
S
E
F
Y
N
N
V
L
G
R
P
Q
-
K
K
R
I
I
V
R
Y
D
G
Y
H
G
S
T
A
L
T
A
A
C
T
G
R
T
G
-
N
W
P
N
-
F
D
----
I
A
Q
D
---
R
I
S
F
L
S
-
S
P
N
P
R
H
----
A
G
------
N
--
R
S
Q
---
E
A
F
L
----
D
D
L
-----
V
Q
E
F
--
E
-----
D
R
I
E
S
L
G
P
D
T
----
I
A
A
F
L
----
A
E
P
I
-
L
A
S
-
G
-
G
V
I
I
P
P
A
G
Y
H
A
R
F
K
A
I
C
E
K
H
D
I
L
Y
I
S
D
E
V
V
T
G
F
G
R
C
G
E
W
F
A
S
E
K
V
-
F
G
V
V
--
P
D
I
I
T
F
A
K
G
V
T
S
G
Y
V
-
P
L
G
G
L
A
I
S
E
A
V
L
A
R
-
I
-
S
-
G
E
-
N
A
K
G
S
W
F
T
N
G
Y
T
Y
S
N
Q
P
V
A
C
A
A
A
L
A
N
I
E
L
M
E
R
E
G
I
V
D
Q
A
R
-
E
M
A
D
---
Y
F
A
A
A
-
L
-
A
S
L
-
R
-
D
L
-
P
G
V
-
A
E
T
R
S
V
G
L
V
G
C
V
Q
C
L
L
D
-------
G
--
T
A
E
D
--
K
--
A
-
F
T
L
-
K
I
D
E
R
C
F
E
L
----
G
L
I
---
V
R
P
L
G
-------
D
L
C
V
I
S
P
P
L
I
I
S
----
R
A
Q
I
D
E
M
V
A
I
M
R
Q
A
I
T
E
------
99
PsiBlast_CBE
47.63
31%
-101
- C1 -
2ZUK
4
ACLR_ACHOB
B:
[46-438]
--------------------------------------------------------------
R
G
A
R
L
I
E
E
-
N
G
--
R
E
L
I
D
-
L
S
G
A
W
G
A
A
S
L
G
Y
G
H
P
A
I
V
A
A
V
S
A
A
A
A
N
P
A
G
-
A
--
T
I-
L
-
S
--
A
----
S
N
A
--
P
--
A
V
T
L
A
E
R
-
L
-
L
A
S
F
P
G
E
GT
H
-
K
-
I
W
F
G
H
S
G
S
D
A
N
E
A
A
Y
R
A
I
V
K
A
T
G
R
S
G
-------
V
I
A
F
A
G
A
Y
H
G
C
T
V
G
S
M
A
F
S
G
H
----------------
A
D
---
G
L
I
L
L
P
-
Y
P
D
P
Y
R
-----
P
------
Y
--
R
-----
N
D
-------
P
T
-----
G
D
A
I
--
L
-----
T
L
L
T
E
K
L
A
A
V
----
P
A
G
S
I
G
A
A
F
I
E
P
I
-
Q
S
D
-
G
-
G
L
I
V
P
P
D
G
F
L
R
K
F
A
D
I
C
R
A
H
G
I
L
V
V
C
D
E
V
K
V
G
L
A
R
S
G
R
L
H
C
F
E
-
H
-
E
G
F
V
--
P
D
I
L
V
L
G
K
G
L
G
G
G
-
L
P
-
L
S
A
V
I
A
P
A
E
I
L
D
C
-
A
-
S
-
A
F
-
A
--------
M
Q
T
L
H
G
N
P
I
S
A
A
A
G
L
A
V
L
E
T
I
D
R
D
D
L
P
A
M
A
E
-
R
K
G
R
---
L
L
R
D
G
-
L
-
S
E
L
A
K
-
R
H
-
P
L
I
-
G
D
I
R
G
R
G
L
A
C
G
M
E
L
V
C
D
R
Q
S
R
E
--
P
--
A
--
R
-----
A
-
E
T
A
-
K
L
I
Y
R
A
Y
Q
L
----
G
L
V
V
Y
Y
V
G
M
N
G
-------
N
V
L
E
F
T
P
P
L
T
I
T
----
E
T
D
I
H
K
A
L
D
L
L
D
R
A
F
S
E
L
-----
98
PsiBlast_CBE
47.41
31%
-100
- C1 -
3DXW
4
ACLR_ACHOB
B:
[46-438]
--------------------------------------------------------------
R
G
A
R
L
I
E
E
-
N
G
--
R
E
L
I
D
-
L
S
G
A
W
G
A
A
S
L
G
Y
G
H
P
A
I
V
A
A
V
S
A
A
A
A
N
P
A
G
-
A
--
T
I-
L
-
S
--
A
----
S
N
A
--
P
--
A
V
T
L
A
E
R
-
L
-
L
A
S
F
P
G
E
GT
H
-
K
-
I
W
F
G
H
S
G
S
D
A
N
E
A
A
Y
R
A
I
V
K
A
T
G
R
S
G
-------
V
I
A
F
A
G
A
Y
H
G
C
T
V
G
S
M
A
F
S
G
H
----------------
A
D
---
G
L
I
L
L
P
-
Y
P
D
P
Y
R
-----
P
------
Y
--
R
-----
N
D
-------
P
T
-----
G
D
A
I
--
L
-----
T
L
L
T
E
K
L
A
A
V
----
P
A
G
S
I
G
A
A
F
I
E
P
I
-
Q
S
D
-
G
-
G
L
I
V
P
P
D
G
F
L
R
K
F
A
D
I
C
R
A
H
G
I
L
V
V
C
D
E
V
K
V
G
L
A
R
S
G
R
L
H
C
F
E
-
H
-
E
G
F
V
--
P
D
I
L
V
L
G
K
G
L
G
G
G
-
L
P
-
L
S
A
V
I
A
P
A
E
I
L
D
C
-
A
-
S
-
A
F
-
A
--------
M
Q
T
L
H
G
N
P
I
S
A
A
A
G
L
A
V
L
E
T
I
D
R
D
D
L
P
A
M
A
E
-
R
K
G
R
---
L
L
R
D
G
-
L
-
S
E
L
A
K
-
R
H
-
P
L
I
-
G
D
I
R
G
R
G
L
A
C
G
M
E
L
V
C
D
R
Q
S
R
E
--
P
--
A
--
R
-----
A
-
E
T
A
-
K
L
I
Y
R
A
Y
Q
L
----
G
L
V
V
Y
Y
V
G
M
N
G
-------
N
V
L
E
F
T
P
P
L
T
I
T
----
E
T
D
I
H
K
A
L
D
L
L
D
R
A
F
S
E
L
-----
100
PsiBlast_CBE
46.98
31%
-109
- C1 -
1MGV
7
BIOA_ECOLI
B:
[31-422]
------------------------------------------------------------
S
A
E
G
C
E
L
I
L
S
-
D
G
--
R
R
L
V
D
G
M
S
S
W
W
-
A
A
I
H
G
Y
N
H
P
Q
L
N
A
A
M
K
S
Q
I
D
A
M
S
H
-
V
--
M
--
F
-
G
--
G
I---
T
H
A
--
P
--
A
I
E
L
C
R
K
-
L
-
V
A
M
T
P
Q
P
--
L
E
C
-
V
F
L
A
D
S
G
S
V
A
V
E
V
A
M
K
M
A
L
Q
Y
W
Q
A
K
G
E
-
A
-
R
Q
R
F
L
T
F
R
N
G
Y
H
G
D
T
F
G
A
M
S
V
C
D
P
D
N
-
S
M
H
S
--------
L
W
K
---
G
Y
L
----
P
E
N
L
F
A
----
P
A
------
P
--
Q
-----
S
R
M
-----
D
G
E
-----
W
D
E
R
--
D
MVGFA
R
L
M
A
A
H
R
H
E
-----
I
A
A
V
I
----
I
E
P
I
-
V
Q
G
A
G
-
G
M
R
M
Y
H
P
E
W
L
K
R
I
R
K
I
C
D
R
E
G
I
L
L
I
A
D
E
I
A
T
G
F
G
R
T
G
K
L
F
A
C
E
-
H
-
A
E
I
A
--
P
D
I
L
C
L
G
K
A
L
T
G
G
-
T
M
T
L
S
A
T
L
T
T
R
E
V
A
E
T
-
I
S
N
-
G
E
-
A
---
G
C
F
M
H
G
P
T
F
M
G
N
P
L
A
C
A
A
A
N
A
S
L
A
I
L
E
S
G
D
W
Q
Q
Q
V
A
-
D
I
E
V
---
Q
L
R
E
Q
-
L
-
A
P
A
-
R
-
D
A
-
E
M
V
-
A
D
V
R
V
L
G
A
I
G
V
V
E
------
T
T
H
--
P
--
V
--
N
--
M
--
A
-
A
L
Q
-
K
F
F
V
-----------------
E
Q
G
V
W
I
A
P
F
G
K
L
I
Y
L
M
P
P
Y
I
I
L
----
P
Q
Q
L
Q
R
L
T
A
A
V
N
R
A
V
Q
-------
112
HHSearch
46.19
31%
-102
- C1 -
4A6R
2
?
A:
[34-448]
--------------------------------------------------------
R
V
M
T
R
G
E
G
V
Y
L
W
D
S
-
E
G
--
N
K
I
I
D
G
M
A
G
L
W
-
C
V
N
V
G
Y
G
R
K
D
F
A
E
A
A
R
R
Q
M
E
E
L
P
F
-
Y
--
N
--
T
-
F
FK
T
----
T
H
P
--
A
--
V
V
E
L
S
S
L
-
L
-
A
E
V
T
P
A
G
F-
D
-
R
-
V
F
Y
T
N
S
G
S
E
S
V
D
T
M
I
R
M
V
R
R
Y
W
D
V
Q
G
K
P
E
-
K
K
T
L
I
G
R
W
N
G
Y
H
G
S
T
I
G
G
A
S
L
G
G
M
K
Y
-
M
H
----
D
----
L
P
I
P
---
G
M
A
H
I
E
-
Q
P
W
W
Y
K
----
H
G
------
K
--
D
MT
P
D
-
E
F
G
-----
V
V
A
-----
A
R
W
L
--
E
-----
E
K
I
L
E
I
G
A
D
K
----
V
A
A
F
V
----
G
E
P
I
-
Q
G
A
-
G
-
G
V
I
V
P
P
A
T
Y
W
P
E
I
E
R
I
C
R
K
Y
D
V
L
L
V
A
D
E
V
I
C
G
F
G
R
T
G
E
W
F
G
H
Q
-
H
-
F
G
F
Q
--
P
D
L
F
T
A
A
K
G
L
S
S
G
Y
L
-
P
I
G
A
V
F
V
G
K
R
V
A
E
G
-
L
-
I
-
A
G
-
G
----
D
F
N
H
G
F
T
Y
S
G
H
P
V
C
A
A
V
A
H
A
N
V
A
A
L
R
D
E
G
I
V
Q
R
V
K
D
D
I
G
P
---
Y
M
Q
K
R
-
W
-
R
E
T
-
F
S
R
F
-
E
H
V
-
D
D
V
R
G
V
G
M
V
Q
A
F
T
L
V
K
N
K
A
K
R
E
--
L
--
F
--
P
DF
G
--
E
-
I
G
T
-
L
C
R
D
I
F
F
R
N
----
N
L
I
---
M
R
A
C
G
-------
D
H
I
V
S
A
P
P
L
V
M
T
----
R
A
E
V
D
E
M
L
A
V
A
E
R
C
L
E
E
------
87
PsiBlast_CBE
43.51
31%
-95
- C1 -
4JEW
13
ARGD_SALTY
B:
[41-404]
--------------------------------------------------------
F
I
P
V
K
G
K
G
S
R
V
W
D
Q
-
Q
G
--
K
E
Y
I
D
F
A
G
G
I
A
-
V
T
A
L
G
H
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
-
T
--
S
--
N
-
V
--
F
----
T
N
E
--
P
--
A
L
R
L
G
R
K
-
L
-
I
D
A
T
F
A
E
--
R
-
V
-
L
F
M
-
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
H
S
P
F
-
K
T
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
-
Y
S
D
G
-
F
G
----
P
-----------
K
-
P
A
D
I
I
H
----
V
P
-----------------------
F
N
D
-----
L
H
A
V
--
K
-----
A
V
M
----
D
D
H
----
T
C
A
V
V
----
V
E
P
I
-
Q
G
E
-
G
-
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
-
H
-
Y
G
V
T
--
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
-
F
-
H
-
V
G
-
S
-------
H
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
-
T
K
R
Q
---
Q
F
V
Q
H
-
L
-
Q
A
I
-
D
-
E
Q
-
F
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
-------
K
--
P
--
K
--
Y
--
K
--
G
-
R
A
R
-
D
F
L
Y
A
G
A
E
A
----
G
V
M
---
V
L
N
A
G
------
A
D
V
M
R
F
A
P
S
L
V
V
E
----
E
A
D
I
-------------------
89
PsiBlast_CBE
43.20
31%
-98
- C1 -
4JEX
17
ARGD_SALTY
B:
[41-404]
--------------------------------------------------------
F
I
P
V
K
G
K
G
S
R
V
W
D
Q
-
Q
G
--
K
E
Y
I
D
F
A
G
G
I
A
-
V
T
A
L
G
H
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
-
T
--
S
--
N
-
V
--
F
----
T
N
E
--
P
--
A
L
R
L
G
R
K
-
L
-
I
D
A
T
F
A
E
--
R
-
V
-
L
F
M
-
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
H
S
P
F
-
K
T
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
-
Y
S
D
G
-
F
G
----
P
-----------
K
-
P
A
D
I
I
H
----
V
P
-----------------------
F
N
D
-----
L
H
A
V
--
K
-----
A
V
M
----
D
D
H
----
T
C
A
V
V
----
V
E
P
I
-
Q
G
E
-
G
-
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
-
H
-
Y
G
V
T
--
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
-
F
---------------
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
-
T
K
R
Q
---
Q
F
V
Q
H
-
L
-
Q
A
I
-
D
-
E
Q
-
F
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
-------
K
--
P
--
K
--
Y
--
K
--
G
-
R
A
R
-
D
F
L
Y
A
G
A
E
A
----
G
V
M
---
V
L
N
A
G
------
A
D
V
M
R
F
A
P
S
L
V
V
E
----
E
A
D
I
-------------------
92
PsiBlast_CBE
42.83
31%
-99
- C1 -
2PB2
6
ARGD_SALTY
A:
[41-404]
--------------------------------------------------------
F
I
P
V
K
G
K
G
S
R
V
W
D
Q
-
Q
G
--
K
E
Y
I
D
F
A
G
G
I
A
-
V
T
A
L
G
H
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
-
T
--
S
--
N
-
V
--
F
----
T
N
E
--
P
--
A
L
R
L
G
R
K
-
L
-
I
D
A
T
F
A
E
--
R
-
V
-
L
F
M
-
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
H
S
P
F
-
K
T
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
-
Y
S
D
G
-
F
G
----
P
-----------
K
-
P
A
D
I
I
H
----
V
P
-----------------------
F
N
D
-----
L
H
A
V
--
K
-----
A
V
M
----
D
D
H
----
T
C
A
V
V
----
V
E
P
I
-
Q
G
E
-
G
-
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
-
H
-
Y
G
V
T
--
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
-
F
--------------
H
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
A
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
-
T
K
R
Q
---
Q
F
V
Q
H
-
L
-
Q
A
I
-
D
-
E
Q
-
F
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
-------
K
--
P
--
K
--
Y
--
K
--
G
-
R
A
R
-
D
F
L
Y
A
G
A
E
A
----
G
V
M
---
V
L
N
A
G
------
A
D
V
M
R
F
A
P
S
L
V
V
E
----
E
A
D
I
-------------------
95
PsiBlast_CBE
42.30
31%
-90
- C1 -
3DXV
2
ACLR_ACHOB
B:
[33-425]
--------------------------------------------------------------
R
G
A
R
L
I
E
E
-
N
G
--
R
E
L
I
D
-
L
S
G
A
W
G
A
A
S
L
G
Y
G
H
P
A
I
V
A
A
V
S
A
A
A
A
N
P
A
G
-
A
--
T
I-
L
-
S
--
A
----
S
N
A
--
P
--
A
V
T
L
A
E
R
-
L
-
L
A
S
F
P
G
E
G
T
H
-
K
-
I
W
F
G
H
S
G
S
D
A
N
E
A
A
Y
R
A
I
V
K
A
T
G
R
S
G
-------
V
I
A
F
A
G
A
Y
H
G
C
T
V
G
S
M
A
F
S
G
H
S
V
-
Q
A
D
A
-
A
K
------
A
D
---
G
L
I
L
L
P
-
Y
P
D
P
Y
R
-----
P
------
Y
--
R
-----
N
D
-------
P
T
-----
G
D
A
I
--
L
-----
T
L
L
T
E
K
L
A
A
V
----
P
A
G
S
I
G
A
A
F
I
E
P
I
-
Q
S
D
-
G
-
G
L
I
V
P
P
D
G
F
L
R
K
F
A
D
I
C
R
A
H
G
I
L
V
V
C
D
E
V
K
V
G
L
A
R
S
G
R
L
H
C
F
E
-
H
-
E
G
F
V
--
P
D
I
L
V
L
G
K
G
L
G
G
G
-
L
P
-
L
S
A
V
I
A
P
A
E
I
L
D
C
-
A
-
S
-
A
F
-
A
--------
M
Q
T
L
H
G
N
P
I
S
A
A
A
G
L
A
V
L
E
T
I
D
R
D
D
L
P
A
M
A
E
-
R
K
G
R
---
L
L
R
D
G
-
L
-
S
E
L
A
K
-
R
H
-
P
L
I
-
G
D
I
R
G
R
G
L
A
C
G
M
E
L
V
C
D
R
Q
S
R
E
--
P
--
A
--
R
-----
A
-
E
T
A
-
K
L
I
Y
R
A
Y
Q
L
----
G
L
V
V
Y
Y
V
G
M
N
G
-------
N
V
L
E
F
T
P
P
L
T
I
T
----
E
T
D
I
H
K
A
L
D
L
L
D
R
A
F
S
E
L
-----
88
PsiBlast_CBE
42.26
31%
-100
- C1 -
4JEW
11
ARGD_SALTY
A:
[41-404]
--------------------------------------------------------
F
I
P
V
K
G
K
G
S
R
V
W
D
Q
-
Q
G
--
K
E
Y
I
D
F
A
G
G
I
A
-
V
T
A
L
G
H
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
-
T
--
S
--
N
-
V
--
F
----
T
N
E
--
P
--
A
L
R
L
G
R
K
-
L
-
I
D
A
T
F
A
E
--
R
-
V
-
L
F
M
-
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
H
S
P
F
-
K
T
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
-
Y
S
D
G
-
F
G
----
P
-----------
K
-
P
A
D
I
I
H
----
V
P
-----------------------
F
N
D
-----
L
H
A
V
--
K
-----
A
V
M
----
D
D
H
----
T
C
A
V
V
----
V
E
P
I
-
Q
G
E
-
G
-
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
-
H
-
Y
G
V
T
--
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
-
F
---------------
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
-
T
K
R
Q
---
Q
F
V
Q
H
-
L
-
Q
A
I
-
D
-
E
Q
-
F
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
-------
K
--
P
--
K
--
Y
--
K
--
G
-
R
A
R
-
D
F
L
Y
A
G
A
E
A
----
G
V
M
---
V
L
N
A
G
------
A
D
V
M
R
F
A
P
S
L
V
V
E
----
E
A
D
I
-------------------
97
PsiBlast_CBE
42.22
31%
-107
- C1 -
1DTY
5
BIOA_ECOLI
A:
[9-422]
------------------
D
E
R
H
I
W
H
PYT--
S
---
M
T
S
P
---
L
---
P
----
V
Y
-
P
--
V
V
S
--
A
E
G
C
E
L
I
L
S
-
D
G
--
R
R
L
V
D
G
M
S
S
W
W
-
A
A
I
H
G
Y
N
H
P
Q
L
N
A
A
M
K
S
Q
I
D
A
M
S
H
-
V
--
M
--
F
-
G
--
E
I---
T
H
A
--
P
--
A
I
E
L
C
R
K
-
L
-
V
A
M
T
P
Q
P
--
L
E
C
-
V
F
L
A
D
S
G
S
V
A
V
E
V
A
M
K
M
A
L
Q
Y
W
D
A
K
G
E
-
A
-
R
D
R
F
L
T
F
R
N
G
Y
H
G
D
T
F
G
A
M
S
V
C
D
P
D
N
-
S
M
H
S
--------
L
W
K
---
G
Y
L
----
P
E
N
L
F
A
----
P
A
------
P
--
Q
-----
S
R
M
-----
D
G
E
-----
W
D
E
R
--
D
MV
G
F
A
R
L
M
A
A
H
R
H
E
-----
I
A
A
V
I
----
I
E
P
I
-
V
Q
G
A
G
-
G
M
R
M
Y
H
P
E
W
L
K
R
I
R
K
I
C
D
R
E
G
I
L
L
I
A
D
E
I
A
T
G
F
G
R
T
G
K
L
F
A
C
E
-
H
-
A
E
I
A
--
P
D
I
L
C
L
G
K
A
L
T
G
G
-
T
M
T
L
S
A
T
L
T
T
R
E
V
A
E
T
-
I
-
S
D
G
E
-
A
---
G
C
F
M
H
G
P
T
F
M
G
N
P
L
A
C
A
A
A
N
A
S
L
A
I
L
E
S
G
D
W
Q
Q
Q
V
A
-
D
I
E
V
---
Q
L
R
E
Q
-
L
-
A
P
A
-
R
-
D
A
-
E
M
V
-
A
D
V
R
V
L
G
A
I
G
V
V
E
------
T
T
H
--
P
--
V
--
N
--
M
--
A
-
A
L
Q
-
K
F
F
V
---
E
Q
----
G
V
W
---
I
R
P
-------
F
G
K
L
I
Y
L
M
P
P
Y
I
I
L
----
P
Q
Q
L
Q
R
L
T
A
A
V
N
R
A
V
Q
-------
93
PsiBlast_CBE
41.61
31%
-97
- C1 -
2PB0
5
ARGD_SALTY
B:
[41-404]
--------------------------------------------------------
F
I
P
V
K
G
K
G
S
R
V
W
D
Q
-
Q
G
--
K
E
Y
I
D
F
A
G
G
I
A
-
V
T
A
L
G
H
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
-
T
--
S
--
N
-
V
--
F
----
T
N
E
--
P
--
A
L
R
L
G
R
K
-
L
-
I
D
A
T
F
A
E
--
R
-
V
-
L
F
M
-
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
H
S
P
F
-
K
T
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
-
Y
S
D
G
-
F
G
----
P
-----------
K
-
P
A
D
I
I
H
----
V
P
-----------------------
F
N
D
-----
L
H
A
V
--
K
-----
A
V
M
----
D
D
H
----
T
C
A
V
V
----
V
E
P
I
-
Q
G
E
-
G
-
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
-
H
-
Y
G
V
T
--
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
-
F
-
H
-
V
G
-
S
-------
H
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
A
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
-
T
K
R
Q
---
Q
F
V
Q
H
-
L
-
Q
A
I
-
D
-
E
Q
-
F
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
-------
K
--
P
--
K
--
Y
--
K
--
G
-
R
A
R
-
D
F
L
Y
A
G
A
E
A
----
G
V
M
---
V
L
N
A
G
------
A
D
V
M
R
F
A
P
S
L
V
V
E
----
E
A
D
I
-------------------
94
PsiBlast_CBE
40.39
31%
-98
- C1 -
2PB0
5
ARGD_SALTY
A:
[41-404]
--------------------------------------------------------
F
I
P
V
K
G
K
G
S
R
V
W
D
Q
-
Q
G
--
K
E
Y
I
D
F
A
G
G
I
A
-
V
T
A
L
G
H
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
-
T
--
S
--
N
-
V
--
F
----
T
N
E
--
P
--
A
L
R
L
G
R
K
-
L
-
I
D
A
T
F
A
E
--
R
-
V
-
L
F
M
-
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
H
S
P
F
-
K
T
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
-
Y
S
D
G
-
F
G
----
P
-----------
K
-
P
A
D
I
I
H
----
V
P
-----------------------
F
N
D
-----
L
H
A
V
--
K
-----
A
V
M
----
D
D
H
----
T
C
A
V
V
----
V
E
P
I
-
Q
G
E
-
G
-
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
-
H
-
Y
G
V
T
--
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
-
F
---------------
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
A
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
-
T
K
R
Q
---
Q
F
V
Q
H
-
L
-
Q
A
I
-
D
-
E
Q
-
F
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
-------
K
--
P
--
K
--
Y
--
K
--
G
-
R
A
R
-
D
F
L
Y
A
G
A
E
A
----
G
V
M
---
V
L
N
A
G
------
A
D
V
M
R
F
A
P
S
L
V
V
E
----
E
A
D
I
-------------------
90
PsiBlast_CBE
40.30
31%
-99
- C1 -
4JEX
17
ARGD_SALTY
A:
[41-404]
--------------------------------------------------------
F
I
P
V
K
G
K
G
S
R
V
W
D
Q
-
Q
G
--
K
E
Y
I
D
F
A
G
G
I
A
-
V
T
A
L
G
H
C
H
P
A
L
V
E
A
L
K
S
Q
G
E
T
L
W
H
-
T
--
S
--
N
-
V
--
F
----
T
N
E
--
P
--
A
L
R
L
G
R
K
-
L
-
I
D
A
T
F
A
E
--
R
-
V
-
L
F
M
-
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
H
S
P
F
-
K
T
K
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
G
Q
P
K
-
Y
S
D
G
-
F
G
----
P
-----------
K
-
P
A
D
I
I
H
----
V
P
-----------------------
F
N
D
-----
L
H
A
V
--
K
-----
A
V
M
----
D
D
H
----
T
C
A
V
V
----
V
E
P
I
-
Q
G
E
-
G
-
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
-
H
-
Y
G
V
T
--
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
-
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
-
F
---------------
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
E
V
L
Q
G
I
H
-
T
K
R
Q
---
Q
F
V
Q
H
-
L
-
Q
A
I
-
D
-
E
Q
-
F
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
-------
K
--
P
--
K
--
Y
--
K
--
G
-
R
A
R
-
D
F
L
Y
A
G
A
E
A
----
G
V
M
---
V
L
N
A
G
------
A
D
V
M
R
F
A
P
S
L
V
V
E
----
E
A
D
I
-------------------
96
PsiBlast_CBE
39.64
31%
-107
- C1 -
1DTY
5
BIOA_ECOLI
B:
[9-422]
------------------
D
E
R
H
I
W
H
PYT--
S
---
M
T
S
P
---
L
---
P
----
V
Y
-
P
--
V
V
S
--
A
E
G
C
E
L
I
L
S
-
D
G
--
R
R
L
V
D
G
M
S
S
W
W
-
A
A
I
H
G
Y
N
H
P
Q
L
N
A
A
M
K
S
Q
I
D
A
M
S
H
-
V
--
M
--
F
-
G
--
E
I---
T
H
A
--
P
--
A
I
E
L
C
R
K
-
L
-
V
A
M
T
P
Q
P
--
L
E
C
-
V
F
L
A
D
S
G
S
V
A
V
E
V
A
M
K
M
A
L
Q
Y
W
D
A
K
G
E
-
A
-
R
D
R
F
L
T
F
R
N
G
Y
H
G
D
T
F
G
A
M
S
V
C
D
P
D
N
-
S
M
H
S
--------
L
W
K
---
G
Y
L
----
P
E
N
L
F
A
----
P
A
------
P
--
Q
-----
S
R
M
-----
D
G
E
-----
W
D
E
R
--
D
MVGFA
R
L
M
A
A
H
R
H
E
-----
I
A
A
V
I
----
I
E
P
I
-
V
Q
G
A
G
-
G
M
R
M
Y
H
P
E
W
L
K
R
I
R
K
I
C
D
R
E
G
I
L
L
I
A
D
E
I
A
T
G
F
G
R
T
G
K
L
F
A
C
E
-
H
-
A
E
I
A
--
P
D
I
L
C
L
G
K
A
L
T
G
G
-
T
M
T
L
S
A
T
L
T
T
R
E
V
A
E
T
-
I
-
S
D
G
E
-
A
---
G
C
F
M
H
G
P
T
F
M
G
N
P
L
A
C
A
A
A
N
A
S
L
A
I
L
E
S
G
D
W
Q
Q
Q
V
A
-
D
I
E
V
---
Q
L
R
E
Q
-
L
-
A
P
A
-
R
-
D
A
-
E
M
V
-
A
D
V
R
V
L
G
A
I
G
V
V
E
------
T
T
H
--
P
--
V
--
N
--
M
--
A
-
A
L
Q
-
K
F
F
V
---
E
Q
----
G
V
W
---
I
R
P
-------
F
G
K
L
I
Y
L
M
P
P
Y
I
I
L
----
P
Q
Q
L
Q
R
L
T
A
A
V
N
R
A
V
Q
-------