@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu14880: (2016-06-23 )
MTNQTARSSKKERYANLIPMEELHSEKDRLFPFPIYDKLRRESPVRYDPLRDCWDVFKYDDVQFVLKNPKLFSSKRGIQTESILTMDPPKHTKLRALVSRAFTPKAVKQLETRIKDVTAFLLQEARQKSTIDIIEDFAGPLPVIIIAEMLGAPIEDRHLIKTYSDVLVAGAKDSSDKAVADMVHNRRDGHAFLSDYFRDILSKRRAEPKEDLMTMLLQAEIDGEYLTEEQLIGFCILLLVAGNETTTNLIANAVRYLTEDSVVQQQVRQNTDNVANVIEETLRYYSPVQAIGRVATEDTELGGVFIKKGSSVISWIASANRDEDKFCKPDCFKIDRPSYPHLSFGFGIHFCLGAPLARLEANIALSSLLSMSACIEKAAHDEKLEAIPSPFVFGVKRLPVRITFK
Atome Classification :
(71 SA)
.........10........20........30........40...---..--------...50--.-.--.---------......60........70-----------------------....--.-----.------------.---------.------.80---------.-----------.----------..------.---------....90........100.......110....-----...120..--.-..-..130.......140.......150..-.....160-.......-.170-----.......180.......190---------..---.....200......-.210......-.220........230.......240.......250..-.....260.......270.--..-....280......-.-290-.-.--.......300........310.......320.......330....-..--.-340..-.....350.......360.......370.......380.......390.......400...-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTN
Q
T
A
R
S
S
K
K
E
R
Y
ANLI
P
M
E
E
L
HSEKDRLFPF
P
I
Y
D
K
L
RRESP---VR--------YD
P
L
---
R
-
D
--
C
---------
W
D
V
FKYD
D
V
Q
F
V
LKNPK------------------------LFSS--K-----R------------G---------I------QT----------E-----------
S
----------
I
L
------T---------MDPP
K
H
T
K
L
R
A
L
V
S
RAF
T
P
K
A
V
K
Q
L
E
T
R
I
K
D
-----
V
T
A
F
L
L
Q
E
--
A
-RQ-K
S
T
I
D
I
I
E
D
FAGP
L
P
V
I
I
I
A
E
M
LGAPI-E
D
R
H
L
I
K
--
T
Y
S
D
V
L
V
-AGAK-----DSS
D
K
A
V
A
D
M
V
HNRRD
G
H
A
F
---------
L
S
---
D
Y
F
R
D
I
L
S
KRRAE
P
-
K
E
D
L
M
T
M
L
L
Q
-AEI-DGEYL
T
E
E
Q
L
I
G
F
C
I
L
L
LVAGN
E
T
T
T
N
L
I
A
N
A
V
-
R
Y
LTE
D
S
V
V
Q
Q
Q
V
R
QNT
D
N
--
V
A
-
N
V
I
E
E
T
L
R
Y
Y
S
P
V
-
Q
-
A
---
I
-
G
--
R
VATEDTEL-
G
G
V
F
I
KKG
S
S
V
I
S
W
I
A
SANRDEDKFCKPD
C
F
KIDR-PS--Y-PHLSF-GFG
I
H
F
CLGA
P
L
A
R
L
E
A
N
I
A
L
S
S
L
L
S
M
S
A
C
I
E
K
AA
H
D
E
K
L
E
AIPS
P
F
V
F
GVKRL
P
V
R
I
TFK-
1
PsiBlast_PDB
79.16
43%
-127
- C5 -
4RM4
1
YJIB_BACSU
A:
[22-396]
---------------------------
D
A
Y
H
P
F
P
W
Y
E
S
M
R
K
D
A
P
---
V
S
--------
F
D
E
E
---
N
-
Q
--
V
---------
W
S
V
F
L
Y
D
D
V
K
K
V
V
G
D
K
E
------------------------
L
F
S
S
--
C
-----
M
-------------------------------G---------
N
-----------
S
----------
I
I
------
N
---------
M
D
P
P
K
H
T
K
I
R
S
V
V
N
K
A
F
T
P
R
V
M
K
Q
W
E
P
R
I
Q
E
-----
I
T
D
E
L
I
Q
K
--
F
-
Q
G
-
R
S
E
F
D
L
V
H
D
F
S
Y
P
L
P
V
I
V
I
S
E
L
L
G
V
P
S
-
A
H
M
E
Q
F
K
--
A
W
S
D
L
L
V
-
S
T
P
K
-----
D
K
S
E
E
A
E
K
A
F
L
E
E
R
D
K
C
E
E
E
---------
L
A
---
A
F
F
A
G
I
I
E
E
K
R
N
K
P
-
E
Q
D
I
I
S
I
L
V
E
------
G
E
K
L
S
G
E
E
L
I
P
F
C
T
L
L
L
V
A
G
N
E
T
T
T
N
L
I
S
N
A
M
-
Y
S
I
L
E
T
P
G
V
Y
E
E
L
R
S
H
P
E
L
--
M
P
-
Q
A
V
E
E
A
L
R
F
R
A
P
A
-
P
-
V
---
L
-
R
--
R
I
A
K
R
D
T
E
I
-
G
G
H
L
I
K
E
G
D
M
V
L
A
F
V
A
S
A
N
R
D
E
A
K
F
D
R
P
H
M
F
D
I
R
R
-
H
P
--
N
-
P
H
I
A
F
-
G
H
G
I
H
F
C
L
G
A
P
L
A
R
L
E
A
N
I
A
L
T
S
L
I
S
A
F
P
H
M
E
C
V
S
----
I
T
P
I
E
N
S
V
I
Y
G
L
K
S
F
R
V
K
M
----
2
PsiBlast_PDB
77.76
37%
-118
- C5 -
4GGV
1
?
A:
[42-418]
---------------------------------------
R
P
E
S
P
---
V
V
--------
F
D
E
T
---
Q
-
G
--
V
---------
W
N
V
Y
G
Y
P
E
A
M
D
I
L
N
D
H
D
------------------------
T
F
T
S
--
D
-----
L
------------
A
HLLP-----
V
------
S
V
----------
D
-----------
A
----------
P
L
LEGDMS
Q
---------
M
D
P
P
R
H
R
K
Y
R
Q
L
V
S
R
A
F
T
P
R
L
V
A
D
M
E
T
R
V
A
D
-----
I
T
R
E
L
L
D
A
--
V
-
D
G
-
K
P
E
I
E
I
A
A
D
L
A
Y
P
L
P
V
I
V
I
A
E
L
L
G
V
P
A
-
G
D
R
D
L
F
K
--
K
W
A
D
D
I
I
-
E
G
F
S
GFSFL
D
T
S
G
Q
G
E
Q
D
-
V
R
D
A
T
E
R
L
R
P
---------
L
L
---
D
Y
M
A
G
H
V
T
E
R
R
R
T
P
-
R
E
D
L
L
T
H
L
V
Q
-
A
E
V
-
D
G
E
R
L
T
D
N
E
I
V
N
V
A
N
I
L
L
V
T
G
H
I
T
T
T
M
T
L
G
N
T
V
-
L
C
L
D
A
D
P
E
V
A
A
K
V
R
A
D
R
S
L
--
V
P
-
G
A
I
E
E
A
L
R
V
L
S
P
S
-
A
-
A
---
L
-
A
--
R
G
T
S
R
E
V
E
V
-
A
G
T
V
I
P
K
D
Q
I
V
M
L
W
L
G
A
G
N
R
D
P
R
Q
F
T
D
P
E
V
Y
D
P
T
R
-
D
P
--
N
-
P
H
F
G
F
-
G
R
G
I
H
F
C
L
G
A
P
L
A
R
L
E
G
R
V
A
L
N
A
L
F
D
R
F
P
V
L
-
R
T
D
P
A
K
P
P
T
F
F
P
T
P
D
M
I
G
V
N
T
L
H
L
R
T
S
---
75
PsiBlast_CBE
76.77
35%
-129
- C5 -
3A51
8
CPVDH_PSEAH
A:
[22-398]
-------------------------------
P
H
P
A
Y
A
A
L
R
A
E
D
P
---
V
R
--------
K
L
A
L
---
P
-
D
G
P
V
---------
W
L
L
T
R
Y
A
D
V
R
E
A
F
V
D
P
R
------------------------
L
S
K
D
--
W
-----
R
HRLPEDQRADMP
A
---------
T
------
P
T
----------
P
-----------
M
----------
M
I
------
L
---------
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
-----
I
A
D
G
L
L
A
G
--
L
-
P
T
-
D
G
P
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
L
P
A
-
E
D
R
D
D
F
S
--
A
W
S
S
V
L
V
-
D
D
S
P
-----
A
D
D
K
N
A
A
M
G
K
L
H
G
----------------------
Y
L
S
D
L
L
E
R
K
R
T
E
P
-
D
D
A
L
L
S
S
L
L
A
V
S
D
M
-
D
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
-
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
L
--
I
S
-
S
A
V
E
E
F
L
R
F
D
S
P
V
S
Q
-
A
---
P
-
I
--
R
F
T
A
E
D
V
T
Y
-
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
-
D
A
--
S
-
G
G
V
F
F
-
G
H
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
E
L
A
L
A
V
G
L
D
E
L
V
Y
R
R
S
T
L
V
R
G
L
S
R
M
P
V
T
M
----
78
PsiBlast_CBE
76.11
35%
-126
- C5 -
3A50
5
CPVDH_PSEAH
C:
[22-398]
-------------------------------
P
H
P
A
Y
A
A
L
R
A
E
D
P
---
V
R
--------
K
L
A
L
---
P
-
D
GP
V
---------
W
L
L
T
R
Y
A
D
V
R
E
A
F
V
D
P
R
------------------------
L
S
K
D
--
W
-----
R
HRLPEDQRADMP
A
---------
T
------
P
T
----------
P
-----------
M
----------
M
I
------
L
---------
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
-----
I
A
D
G
L
L
A
G
--
L
-
P
T
-
D
G
P
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
L
P
A
-
E
D
R
D
D
F
S
--
A
W
S
S
V
L
V
-
D
D
S
P
-----
A
D
D
K
N
A
A
M
G
K
L
H
G
----------------------
Y
L
S
D
L
L
E
R
K
R
T
E
P
-
D
D
A
L
L
S
S
L
L
A
V
S
D
M
-
D
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
-
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
L
--
I
S
-
S
A
V
E
E
F
L
R
F
D
S
P
V
S
Q
-
A
---
P
-
I
--
R
F
T
A
E
D
V
T
Y
-
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
-
D
A
--
S
-
G
G
V
F
F
-
G
H
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
E
L
A
L
A
V
G
L
D
E
L
V
Y
R
R
S
T
L
V
R
G
L
S
R
M
P
V
T
M
----
101
PsiBlast_CBE
75.93
34%
-120
- C5 -
2Z3U
8
?
A:
[16-394]
-------------------------
K
K
D
I
A
D
P
Y
P
V
Y
R
R
Y
R
E
A
A
P
---
V
H
R
T
A
-----
S
G
P
G
---
K
P
D
--
T
---------
Y
Y
V
F
T
Y
D
D
V
V
R
V
L
S
N
R
R
------------------------
L
G
R
N
--
A
-----
R
V
A
S
GDTDTAPV-
P
---------
I
------
P
T
----------
E
-----------
H
R
A
L
R
T
V
V
E
N
W
L
V
------
F
---------
L
D
P
P
H
H
T
E
L
R
S
L
L
T
T
E
F
S
P
S
I
V
T
G
L
R
P
R
I
A
E
-----
L
A
S
A
L
L
D
R
--
L
-
R
A
-
Q
R
R
P
D
L
V
E
G
F
A
A
P
L
P
I
L
V
I
S
A
L
L
G
I
P
E
-
E
D
H
T
W
L
R
--
A
N
A
---
V
-
A
L
Q
E
-----
A
S
T
T
R
A
--------
R
D
G
R
G
Y
A
R
A
E
A
A
S
Q
E
F
T
---
R
Y
F
R
R
E
V
D
R
R
G
G
D
D
-
R
D
D
L
L
T
L
L
V
R
-
A
R
D
-
T
G
S
P
L
S
V
D
G
I
V
G
T
C
V
H
L
L
T
A
G
H
E
T
T
T
N
F
L
A
K
A
V
-
L
T
L
R
A
H
R
D
V
L
D
E
L
R
T
T
P
E
S
--
T
P
-
A
A
V
E
E
L
M
R
Y
D
P
P
V
-
Q
-
A
---
V
-
T
--
R
W
A
Y
E
D
I
R
L
-
G
D
H
D
I
P
R
G
S
R
V
V
A
L
L
G
S
A
N
R
D
P
A
R
F
P
D
P
D
V
L
D
V
H
R
-
A
A
--
E
-
R
Q
V
G
F
-
G
L
G
I
H
Y
C
L
G
A
T
L
A
R
A
E
A
E
I
G
L
R
A
L
L
D
G
I
P
A
L
G
R
G
A
H
E
-------------------------
83
PsiBlast_CBE
75.89
35%
-126
- C5 -
3A4Z
4
CPVDH_PSEAH
C:
[22-398]
-------------------------------
P
H
P
A
Y
A
A
L
R
A
E
D
P
---
V
R
--------
K
L
A
L
---
P
-
D
GP
V
---------
W
L
L
T
R
Y
A
D
V
R
E
A
F
V
D
P
R
------------------------
L
S
K
D
--
W
-----
R
HRLPEDQRADMP
A
---------
T
------
P
T
----------
P
-----------
M
----------
M
I
------
L
---------
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
-----
I
A
D
G
L
L
A
G
--
L
-
P
T
-
D
G
P
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
L
P
A
-
E
D
R
D
D
F
S
--
A
W
S
S
V
L
V
-
D
D
S
P
-----
A
D
D
K
N
A
A
M
G
K
L
H
G
----------------------
Y
L
S
D
L
L
E
R
K
R
T
E
P
-
D
D
A
L
L
S
S
L
L
A
V
S
D
M
-
D
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
-
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
L
--
I
S
-
S
A
V
E
E
F
L
R
F
D
S
P
V
S
Q
-
A
---
P
-
I
--
R
F
T
A
E
D
V
T
Y
-
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
-
D
A
--
S
-
G
G
V
F
F
-
G
H
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
E
L
A
L
A
V
G
L
D
E
L
V
Y
R
R
S
T
L
V
R
G
L
S
R
M
P
V
T
M
----
73
PsiBlast_CBE
75.83
35%
-127
- C5 -
3A51
5
CPVDH_PSEAH
C:
[22-398]
-------------------------------
P
H
P
A
Y
A
A
L
R
A
E
D
P
---
V
R
--------
K
L
A
L
---
P
-
D
GP
V
---------
W
L
L
T
R
Y
A
D
V
R
E
A
F
V
D
P
R
------------------------
L
S
K
D
--
W
-----
R
HRLPEDQRADMP
A
---------
T
------
P
T
----------
P
-----------
M
----------
M
I
------
L
---------
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
-----
I
A
D
G
L
L
A
G
--
L
-
P
T
-
D
G
P
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
L
P
A
-
E
D
R
D
D
F
S
--
A
W
S
S
V
L
V
-
D
D
S
P
-----
A
D
D
K
N
A
A
M
G
K
L
H
G
----------------------
Y
L
S
D
L
L
E
R
K
R
T
E
P
-
D
D
A
L
L
S
S
L
L
A
V
S
D
M
-
D
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
-
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
L
--
I
S
-
S
A
V
E
E
F
L
R
F
D
S
P
V
S
Q
-
A
---
P
-
I
--
R
F
T
A
E
D
V
T
Y
-
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
-
D
A
--
S
-
G
G
V
F
F
-
G
H
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
E
L
A
L
A
V
G
L
D
E
L
V
Y
R
R
S
T
L
V
R
G
L
S
R
M
P
V
T
M
----
74
PsiBlast_CBE
75.75
35%
-126
- C5 -
3A51
3
CPVDH_PSEAH
B:
[22-398]
-------------------------------
P
H
P
A
Y
A
A
L
R
A
E
D
P
---
V
R
--------
K
L
A
L
---
P
-
D
GP
V
---------
W
L
L
T
R
Y
A
D
V
R
E
A
F
V
D
P
R
------------------------
L
S
K
D
--
W
-----
R
HRLPEDQRADMP
A
---------
T
------
P
T
----------
P
-----------
M
----------
M
I
------
L
---------
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
-----
I
A
D
G
L
L
A
G
--
L
-
P
T
-
D
G
P
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
L
P
A
-
E
D
R
D
D
F
S
--
A
W
S
S
V
L
V
-
D
D
S
P
-----
A
D
D
K
N
A
A
M
G
K
L
H
G
----------------------
Y
L
S
D
L
L
E
R
K
R
T
E
P
-
D
D
A
L
L
S
S
L
L
A
V
S
D
M
-
D
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
-
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
L
--
I
S
-
S
A
V
E
E
F
L
R
F
D
S
P
V
S
Q
-
A
---
P
-
I
--
R
F
T
A
E
D
V
T
Y
-
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
-
D
A
--
S
-
G
G
V
F
F
-
G
H
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
E
L
A
L
A
V
G
L
D
E
L
V
Y
R
R
S
T
L
V
R
G
L
S
R
M
P
V
T
M
----
84
PsiBlast_CBE
75.62
35%
-125
- C5 -
3A4Z
2
CPVDH_PSEAH
B:
[22-398]
-------------------------------
P
H
P
A
Y
A
A
L
R
A
E
D
P
---
V
R
--------
K
L
A
L
---
P
-
D
GP
V
---------
W
L
L
T
R
Y
A
D
V
R
E
A
F
V
D
P
R
------------------------
L
S
K
D
--
W
-----
R
HRLPEDQRADMP
A
---------
T
------
P
T
----------
P
-----------
M
----------
M
I
------
L
---------
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
-----
I
A
D
G
L
L
A
G
--
L
-
P
T
-
D
G
P
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
L
P
A
-
E
D
R
D
D
F
S
--
A
W
S
S
V
L
V
-
D
D
S
P
-----
A
D
D
K
N
A
A
M
G
K
L
H
G
----------------------
Y
L
S
D
L
L
E
R
K
R
T
E
P
-
D
D
A
L
L
S
S
L
L
A
V
S
D
M
-
D
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
-
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
L
--
I
S
-
S
A
V
E
E
F
L
R
F
D
S
P
V
S
Q
-
A
---
P
-
I
--
R
F
T
A
E
D
V
T
Y
-
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
-
D
A
--
S
-
G
G
V
F
F
-
G
H
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
E
L
A
L
A
V
G
L
D
E
L
V
Y
R
R
S
T
L
V
R
G
L
S
R
M
P
V
T
M
----
88
PsiBlast_CBE
75.57
32%
-116
- C5 -
4Z5P
2
?
B:
[8-398]
--------------
V
H
I
Y
P
F
E
---
G
E
V
D
G
L
E
I
H
P
K
F
A
E
L
R
E
T
D
P
LAR
V
R
--------
L
P
Y
G
---
G
-
E
--
G
---------
W
M
V
T
R
Y
D
D
V
R
A
A
N
S
D
P
R
------------------------
F
S
R
A
--
Q
-----
I
------------
G
---------
E
------
D
T
PRTTP-----
D
-----------
T
----------
I
L
------
S
---------
L
D
P
P
E
H
T
R
L
R
R
L
L
S
K
A
F
T
A
R
R
M
G
A
M
Q
S
W
L
E
E
-----
L
F
A
G
L
L
D
G
--
V
E
R
T
-
G
H
P
A
D
I
V
R
D
L
A
Q
P
F
T
I
A
V
I
C
R
L
L
G
V
P
Y
-
E
D
R
G
R
F
Q
--
H
W
S
E
V
I
M
-
S
T
T
A
-----
Y
S
K
E
E
A
V
S
--------
A
D
A
S
---------
I
R
---
A
Y
L
A
D
L
V
S
A
R
R
A
A
P
-
H
D
D
L
L
G
V
L
V
S
-
A
R
D
-
D
D
D
R
L
T
E
D
E
L
I
T
F
G
V
T
L
L
V
A
G
H
E
T
S
A
H
Q
L
G
N
M
V
-
Y
A
L
L
T
H
E
D
Q
L
S
L
L
R
E
Q
P
E
L
--
L
P
-
R
A
V
E
E
L
L
R
F
V
P
L
G
-
N
-
G
---
V
-
G
NA
R
I
A
L
E
D
V
E
L
-
S
G
G
T
V
R
A
G
E
G
V
V
A
A
A
V
N
A
N
R
D
P
R
A
F
D
D
P
D
R
L
D
I
T
R
-
E
K
--
N
-
P
H
L
A
F
-
G
H
G
A
H
Y
C
L
G
A
Q
L
A
R
M
E
L
R
V
A
I
G
G
L
L
E
R
F
P
G
L
R
L
A
V
P
A
D
Q
V
E
W
K
T
G
G
L
F
R
G
P
Q
R
L
P
I
------
105
PsiBlast_CBE
75.34
32%
-119
- C5 -
4TRI
3
?
B:
[57-394]
--------------------------------------------------------------------------------------------
R
N
P
E
------------------------
L
F
S
S
--
T
-----
G
------------
G
---------
I
------
R
P
----------
D
-----------
Q
PGMPY-----
M
I
------
D
---------
M
D
D
P
Q
H
L
L
R
R
K
L
V
N
A
G
F
T
R
K
R
V
M
D
K
V
D
S
I
G
R
-----
L
C
D
T
L
I
D
A
--
V
-
C
E
-
R
G
E
C
D
F
V
R
D
I
A
A
P
L
P
M
A
V
I
G
D
M
L
G
V
L
P
-
T
E
R
D
M
L
L
--
K
W
S
D
D
L
V
-
C
G
L
S
-----
S
H
V
D
E
A
A
---
I
Q
K
L
M
D
T
F
A
A
---------
Y
T
---
E
F
T
K
D
V
I
T
K
R
R
A
E
P
-
T
D
D
L
F
S
V
L
V
N
-
S
E
V
-
E
G
Q
R
M
S
D
D
E
I
V
F
E
T
L
L
I
L
I
G
G
D
E
T
T
R
H
T
L
S
G
G
T
-
E
Q
L
L
R
H
R
D
Q
W
D
A
L
V
A
D
V
D
L
--
L
P
-
G
A
I
E
E
M
L
R
W
T
S
P
V
-
K
-
N
---
M
-
C
--
R
T
L
T
A
D
T
V
F
-
H
G
T
E
L
R
A
G
E
K
I
M
L
M
F
E
S
A
N
F
D
E
S
V
F
G
D
P
D
N
F
R
I
D
R
-
N
P
--
N
-
S
H
V
A
F
-
G
F
G
T
H
F
C
L
G
N
Q
L
A
R
L
E
L
R
L
M
T
E
R
V
L
R
R
L
P
D
L
-
R
L
A
D
D
A
P
V
P
L
R
P
A
N
F
V
S
G
P
E
S
M
P
V
V
F
T
---
3
PsiBlast_PDB
75.34
36%
-122
- C5 -
4YT3
3
?
A:
[22-384]
-------------------------------
P
Y
A
W
C
K
R
M
L
E
N
D
P
---
V
S
--------
Y
H
E
G
---
T
-
D
--
T
---------
W
N
V
F
K
Y
E
D
V
K
R
V
L
S
D
Y
K
------------------------
H
F
S
S
--
V
-----
R
------------
K
------------------------------------------------------------VPEKIQITE
S
D
P
P
D
H
R
K
R
R
S
L
L
A
A
A
F
T
P
R
S
L
Q
N
W
E
P
R
I
Q
E
-----
I
A
D
E
L
I
G
Q
--
M
-
D
G
--
T
E
I
D
I
V
A
S
L
A
S
P
L
P
I
I
V
M
A
D
L
M
G
V
P
S
-
K
D
R
L
L
F
K
--
K
W
V
D
T
L
F
-
L
P
F
---------
Q
E
E
V
D
K
L
---
K
Q
V
A
A
K
E
---------
Y
Y
---
Q
Y
L
Y
P
I
V
V
Q
K
R
L
N
P
-
A
D
D
I
I
S
D
L
L
K
-
S
E
V
-
D
G
E
M
F
T
D
D
E
V
V
R
T
T
M
L
I
L
G
A
G
V
E
T
T
S
H
L
L
A
N
S
F
Y
S
L
L
Y
D
D
K
E
V
Y
Q
E
L
H
E
N
L
D
L
--
V
P
-
Q
A
V
E
E
M
L
R
F
R
F
N
L
-
I
-
K
---
L
-
D
--
R
T
V
K
E
D
N
D
L
-
L
G
V
E
L
K
E
G
D
S
V
V
V
W
M
S
A
A
N
M
D
E
E
M
F
E
D
P
F
T
L
N
I
H
R
-
P
N
--
N
K
K
H
L
T
F
-
G
N
G
P
H
F
C
L
G
A
P
L
A
R
L
E
A
K
I
A
L
T
A
F
L
------
K
K
F
K
H
---
I
E
A
V
P
S
-----------------
21
PsiBlast_CBE
75.32
36%
-126
- C5 -
4YT3
2
?
B:
[22-384]
-------------------------------
P
Y
A
W
C
K
R
M
L
E
N
D
P
---
V
S
--------
Y
H
E
G
---
T
-
D
--
T
---------
W
N
V
F
K
Y
E
D
V
K
R
V
L
S
D
Y
K
------------------------
H
F
S
S
--
V
-----
R
-------------------------------------------------------------------------VPEKIQITE
S
D
P
P
D
H
R
K
R
R
S
L
L
A
A
A
F
T
P
R
S
L
Q
N
W
E
P
R
I
Q
E
-----
I
A
D
E
L
I
G
Q
--
M
-
D
G
-
G
T
E
I
D
I
V
A
S
L
A
S
P
L
P
I
I
V
M
A
D
L
M
G
V
P
S
-
K
D
R
L
L
F
K
--
K
W
V
D
T
L
F
-
L
P
F
---------
Q
E
E
V
D
K
L
---
K
Q
V
A
A
K
E
---------
Y
Y
---
Q
Y
L
Y
P
I
V
V
Q
K
R
L
N
P
-
A
D
D
I
I
S
D
L
L
K
-
S
E
V
-
D
G
E
M
F
T
D
D
E
V
V
R
T
T
M
L
I
L
G
A
G
V
E
T
T
S
H
L
L
A
N
S
F
Y
S
L
L
Y
D
D
K
E
V
Y
Q
E
L
H
E
N
L
D
L
--
V
P
-
Q
A
V
E
E
M
L
R
F
R
F
N
L
-
I
-
K
---
L
-
D
--
R
T
V
K
E
D
N
D
L
-
L
G
V
E
L
K
E
G
D
S
V
V
V
W
M
S
A
A
N
M
D
E
E
M
F
E
D
P
F
T
L
N
I
H
R
-
P
N
--
N
K
K
H
L
T
F
-
G
N
G
P
H
F
C
L
G
A
P
L
A
R
L
E
A
K
I
A
L
T
A
F
L
------
K
K
F
K
H
---
I
E
A
V
P
S
-----------------
87
PsiBlast_CBE
75.31
35%
-125
- C5 -
3A4G
2
CPVDH_PSEAH
A:
[22-398]
-------------------------------
P
H
P
A
Y
A
A
L
R
A
E
D
P
---
V
R
--------
K
L
A
L
---
P
-
D
G
P
V
---------
W
L
L
T
R
Y
A
D
V
R
E
A
F
V
D
P
R
------------------------
L
S
K
D
--
W
-----
R
HTLPEDQRADMP
A
---------
T
------
P
T
----------
P
-----------
M
----------
M
I
------
L
---------
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
-----
I
A
D
G
L
L
A
G
--
L
-
P
T
-
D
G
P
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
V
P
A
-
E
D
R
D
D
F
S
--
A
W
S
S
V
L
V
-
D
D
S
P
-----
A
D
D
K
N
A
A
M
G
K
L
H
G
----------------------
Y
L
S
D
L
L
E
R
K
R
T
E
P
-
D
D
A
L
L
S
S
L
L
A
V
S
D
E
-
D
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
-
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
L
--
I
S
-
S
A
V
E
E
F
L
R
F
D
S
P
V
S
Q
-
A
---
P
-
I
--
R
F
T
A
E
D
V
T
Y
-
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
-
D
A
--
S
-
G
G
V
F
F
-
G
H
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
E
L
A
L
A
V
G
L
D
E
L
V
Y
R
E
S
T
L
V
R
G
L
S
R
M
P
V
T
M
----
79
PsiBlast_CBE
75.23
35%
-124
- C5 -
3A50
2
CPVDH_PSEAH
B:
[22-398]
-------------------------------
P
H
P
A
Y
A
A
L
R
A
E
D
P
---
V
R
--------
K
L
A
L
---
P
-
D
GP
V
---------
W
L
L
T
R
Y
A
D
V
R
E
A
F
V
D
P
R
------------------------
L
S
K
D
--
W
-----
R
HRLPEDQRADMP
A
---------
T
------
P
T
----------
P
-----------
M
----------
M
I
------
L
---------
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
-----
I
A
D
G
L
L
A
G
--
L
-
P
T
-
D
G
P
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
L
P
A
-
E
D
R
D
D
F
S
--
A
W
S
S
V
L
V
-
D
D
S
P
-----
A
D
D
K
N
A
A
M
G
K
L
H
G
----------------------
Y
L
S
D
L
L
E
R
K
R
T
E
P
-
D
D
A
L
L
S
S
L
L
A
V
S
D
M
-
D
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
-
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
L
--
I
S
-
S
A
V
E
E
F
L
R
F
D
S
P
V
S
Q
-
A
---
P
-
I
--
R
F
T
A
E
D
V
T
Y
-
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
-
D
A
--
S
-
G
G
V
F
F
-
G
H
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
E
L
A
L
A
V
G
L
D
E
L
V
Y
R
R
S
T
L
V
R
G
L
S
R
M
P
V
T
M
----
71
PsiBlast_CBE
75.21
35%
-123
- C5 -
3A51
4
CPVDH_PSEAH
E:
[22-398]
-------------------------------
P
H
P
A
Y
A
A
L
R
A
E
D
P
---
V
R
--------
K
L
A
L
---
P
-
D
GP
V
---------
W
L
L
T
R
Y
A
D
V
R
E
A
F
V
D
P
R
------------------------
L
S
K
D
--
W
-----
R
HRLPEDQRADMP
A
---------
T
------
P
T
----------
P
-----------
M
----------
M
I
------
L
---------
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
-----
I
A
D
G
L
L
A
G
--
L
-
P
T
-
D
G
P
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
L
P
A
-
E
D
R
D
D
F
S
--
A
W
S
S
V
L
V
-
D
D
S
P
-----
A
D
D
K
N
A
A
M
G
K
L
H
G
----------------------
Y
L
S
D
L
L
E
R
K
R
T
E
P
-
D
D
A
L
L
S
S
L
L
A
V
S
D
M
-
D
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
-
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
L
--
I
S
-
S
A
V
E
E
F
L
R
F
D
S
P
V
S
Q
-
A
---
P
-
I
--
R
F
T
A
E
D
V
T
Y
-
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
-
D
A
--
S
-
G
G
V
F
F
-
G
H
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
E
L
A
L
A
V
G
L
D
E
L
V
Y
R
R
S
T
L
V
R
G
L
S
R
M
P
V
T
M
----
76
PsiBlast_CBE
75.11
35%
-124
- C5 -
3A50
4
CPVDH_PSEAH
E:
[22-398]
-------------------------------
P
H
P
A
Y
A
A
L
R
A
E
D
P
---
V
R
--------
K
L
A
L
---
P
-
D
GP
V
---------
W
L
L
T
R
Y
A
D
V
R
E
A
F
V
D
P
R
------------------------
L
S
K
D
--
W
-----
R
HRLPEDQRADMP
A
---------
T
------
P
T
----------
P
-----------
M
----------
M
I
------
L
---------
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
-----
I
A
D
G
L
L
A
G
--
L
-
P
T
-
D
G
P
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
L
P
A
-
E
D
R
D
D
F
S
--
A
W
S
S
V
L
V
-
D
D
S
P
-----
A
D
D
K
N
A
A
M
G
K
L
H
G
----------------------
Y
L
S
D
L
L
E
R
K
R
T
E
P
-
D
D
A
L
L
S
S
L
L
A
V
S
D
M
-
D
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
-
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
L
--
I
S
-
S
A
V
E
E
F
L
R
F
D
S
P
V
S
Q
-
A
---
P
-
I
--
R
F
T
A
E
D
V
T
Y
-
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
-
D
A
--
S
-
G
G
V
F
F
-
G
H
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
E
L
A
L
A
V
G
L
D
E
L
V
Y
R
R
S
T
L
V
R
G
L
S
R
M
P
V
T
M
----
80
PsiBlast_CBE
75.10
35%
-126
- C5 -
3A50
8
CPVDH_PSEAH
A:
[22-398]
-------------------------------
P
H
P
A
Y
A
A
L
R
A
E
D
P
---
V
R
--------
K
L
A
L
---
P
-
D
G
P
V
---------
W
L
L
T
R
Y
A
D
V
R
E
A
F
V
D
P
R
------------------------
L
S
K
D
--
W
-----
R
HRLPEDQRADMP
A
---------
T
------
P
T
----------
P
-----------
M
----------
M
I
------
L
---------
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
-----
I
A
D
G
L
L
A
G
--
L
-
P
T
-
D
G
P
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
L
P
A
-
E
D
R
D
D
F
S
--
A
W
S
S
V
L
V
-
D
D
S
P
-----
A
D
D
K
N
A
A
M
G
K
L
H
G
----------------------
Y
L
S
D
L
L
E
R
K
R
T
E
P
-
D
D
A
L
L
S
S
L
L
A
V
S
D
M
-
D
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
-
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
L
--
I
S
-
S
A
V
E
E
F
L
R
F
D
S
P
V
S
Q
-
A
---
P
-
I
--
R
F
T
A
E
D
V
T
Y
-
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
-
D
A
--
S
-
G
G
V
F
F
-
G
H
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
E
L
A
L
A
V
G
L
D
E
L
V
Y
R
R
S
T
L
V
R
G
L
S
R
M
P
V
T
M
----
86
PsiBlast_CBE
74.98
35%
-122
- C5 -
3A4H
2
CPVDH_PSEAH
A:
[22-398]
-------------------------------
P
H
P
A
Y
A
A
L
R
A
E
D
P
---
V
R
--------
K
L
A
L
---
P
-
D
G
P
V
---------
W
L
L
T
R
Y
A
D
V
R
E
A
F
V
D
P
R
------------------------
L
S
K
D
--
W
-----
R
HTLPEDQRADMP
A
---------
T
------
P
T
----------
P
-----------
M
----------
M
I
------
L
---------
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
-----
I
A
D
G
L
L
A
G
--
L
-
P
T
-
D
G
P
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
V
P
A
-
E
D
R
D
D
F
S
--
A
W
S
S
V
L
V
-
D
D
S
P
-----
A
D
D
K
N
A
A
M
G
K
L
H
G
----------------------
Y
L
S
D
L
L
E
R
K
R
T
E
P
-
D
D
A
L
L
S
S
L
L
A
V
S
D
E
-
D
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
-
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
L
--
I
S
-
S
A
V
E
E
F
L
R
F
D
S
P
V
S
Q
-
A
---
P
-
I
--
R
F
T
A
E
D
V
T
Y
-
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
-
D
A
--
S
-
G
G
V
F
F
-
G
H
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
E
L
A
L
A
V
G
L
D
E
L
V
Y
R
E
S
T
L
V
R
G
L
S
R
M
P
V
T
M
----
85
PsiBlast_CBE
74.98
35%
-124
- C5 -
3A4Z
7
CPVDH_PSEAH
A:
[22-398]
-------------------------------
P
H
P
A
Y
A
A
L
R
A
E
D
P
---
V
R
--------
K
L
A
L
---
P
-
D
G
P
V
---------
W
L
L
T
R
Y
A
D
V
R
E
A
F
V
D
P
R
------------------------
L
S
K
D
--
W
-----
R
HRLPEDQRADMP
A
---------
T
------
P
T
----------
P
-----------
M
----------
M
I
------
L
---------
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
-----
I
A
D
G
L
L
A
G
--
L
-
P
T
-
D
G
P
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
L
P
A
-
E
D
R
D
D
F
S
--
A
W
S
S
V
L
V
-
D
D
S
P
-----
A
D
D
K
N
A
A
M
G
K
L
H
G
----------------------
Y
L
S
D
L
L
E
R
K
R
T
E
P
-
D
D
A
L
L
S
S
L
L
A
V
S
D
M
-
D
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
-
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
L
--
I
S
-
S
A
V
E
E
F
L
R
F
D
S
P
V
S
Q
-
A
---
P
-
I
--
R
F
T
A
E
D
V
T
Y
-
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
-
D
A
--
S
-
G
G
V
F
F
-
G
H
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
E
L
A
L
A
V
G
L
D
E
L
V
Y
R
R
S
T
L
V
R
G
L
S
R
M
P
V
T
M
----
142
HHSearch
74.91
36%
-117
- C5 -
3A4G
2
CPVDH_PSEAH
A:
[19-401]
----------------------------
W
Q
N
P
H
P
A
Y
A
A
L
R
A
E
D
P
---
V
R
--------
K
L
A
L
PD-
G
-
P
--
V
---------
W
L
L
T
R
Y
A
D
V
R
E
A
F
V
D
P
R
L-----------------------
S
K
D
W
--
R
-----
H
------------
T
LPEDQRADM
P
AT----
P
T
----------
P
-----------
M
----------
M
I
------
L
---------
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
T
V
R
R
M
N
E
L
E
P
R
I
T
E
-----
I
A
D
G
L
L
A
G
--
L
-
P
T
-
D
G
P
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
V
P
A
-
E
D
R
D
D
F
S
--
A
W
S
S
V
L
V
-
D
D
--------
S
-----
P
A
--
D
D
K
N
A
A
M
G
K
---------
L
H
---
G
Y
L
S
D
L
L
E
R
K
R
T
E
P
-
D
D
A
L
L
S
S
L
L
A
-
V
S
D
E
D
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
-
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
L
--
I
S
-
S
A
V
E
E
F
L
R
F
D
S
P
V
-
S
-
Q
A--
P
-
I
--
R
F
T
A
E
D
V
T
Y
-
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
D
A
S
----
G
G
V
F
F
-
G
H
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
E
L
A
L
A
V
G
L
D
E
L
V
Y
R
E
S
T
L
V
R
G
L
S
R
M
P
V
T
M
G
P
R
-
5
PsiBlast_PDB
74.72
38%
-126
- C5 -
3ZKP
2
ERYK_SACEN
A:
[37-401]
--------------------------------------
M
R
E
K
Q
P
---
V
W
--------
Q
D
-
R
---
Y
-
G
--
V
---------
W
H
V
F
R
H
A
D
V
Q
T
V
L
R
D
T
A
------------------------
T
F
S
S
DP
T
-----
R
------------
V
---------
I
------
E
G
----------
A
-----------
S
PTPGA-----
I
H
------
E
---------
I
D
P
P
E
H
R
A
L
R
K
V
V
S
S
A
F
T
P
R
T
I
S
D
L
E
P
R
I
R
D
-----
V
T
R
S
L
L
A
D
--
A
-
G
E
---
S
F
D
L
V
D
V
L
A
F
P
L
P
V
T
I
V
A
E
L
L
G
L
P
P
-
M
D
H
E
Q
F
G
--
D
W
S
G
A
L
V
D
I
Q
M
D
-----
D
P
T
D
P
A
L
A
E
R
I
A
D
V
L
N
P
------------
L
T
---
A
Y
L
K
A
R
C
A
E
R
R
A
D
P
-
G
D
D
L
I
S
R
L
V
L
-
A
E
V
-
D
G
R
A
L
D
D
E
E
A
A
N
F
S
T
A
L
L
L
A
G
H
I
T
T
T
V
L
L
G
N
I
V
-
R
T
L
D
E
H
P
A
H
W
D
A
A
A
E
D
P
G
R
--
I
P
-
A
I
V
E
E
V
L
R
Y
R
P
P
F
-
P
-
Q
---
M
-
Q
--
R
T
T
T
K
A
T
E
V
-
A
G
V
P
I
P
A
D
V
M
V
N
T
W
V
L
S
A
N
R
D
S
D
A
H
D
D
P
D
R
F
D
P
S
R
-
K
S
GG
A
-
A
Q
L
S
F
-
G
H
G
V
H
F
C
L
G
A
P
L
A
R
L
E
N
R
V
A
L
E
E
I
I
A
R
F
G
R
L
T
V
D
R
D
D
E
R
L
R
H
F
E
Q
-
I
V
L
G
T
R
H
L
P
V
------
70
PsiBlast_CBE
74.52
35%
-119
- C5 -
2BVJ
3
PIKC_STRVZ
A:
[48-424]
-------------------------------
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
--------
T
P
E
G
---
D
-
E
--
V
---------
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
------------------------
F
S
K
D
--
W
-----
R
------------
N
---------
S
------
T
T
P
L
T
E
A
E
A
A
L
N
H
-----------
N
----------
M
L
------
E
---------
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
-----
I
V
D
G
L
V
D
A
M
L
A
-
A
P
-
D
G
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
-
P
D
R
A
A
F
R
--
V
W
T
D
A
F
V
-
F
--
P
-----
D
D
P
A
Q
A
Q
T
A
M
--------
A
E
---------
M
S
---
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
-
G
E
D
L
L
S
A
L
V
R
T
S
D
E
-
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
-
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
--
L
D
-
G
A
V
E
E
M
L
R
Y
E
G
P
V
-
E
S
A
---
T
-
Y
--
R
F
P
V
E
P
V
D
L
-
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
-
D
T
--
A
-
G
H
L
A
F
-
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
-----
61
PsiBlast_CBE
74.46
35%
-116
- C5 -
4B7D
3
PIKC_STRVZ
A:
[48-424]
-------------------------------
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
--------
T
P
E
G
---
D
-
E
--
V
---------
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
------------------------
F
S
K
D
--
W
-----
R
------------
N
---------
S
------
T
T
P
L
T
E
A
E
A
A
L
N
H
-----------
N
----------
M
L
------
E
---------
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
-----
I
V
D
G
L
V
D
A
M
L
A
-
A
P
-
D
G
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
-
P
D
R
A
A
F
R
--
V
W
T
D
A
F
V
-
F
--
P
-----
D
D
P
A
Q
A
Q
T
A
M
--------
A
E
---------
M
S
---
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
-
G
E
D
L
L
S
A
L
V
R
T
S
D
E
-
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
-
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
--
L
D
-
G
A
V
E
E
M
L
R
Y
E
G
P
V
-
E
S
A
---
T
-
Y
--
R
F
P
V
E
P
V
D
L
-
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
-
D
T
--
A
-
G
H
L
A
F
-
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
-----
44
PsiBlast_CBE
74.39
35%
-117
- C5 -
3ZPI
6
PIKC_STRVZ
B:
[48-424]
-------------------------------
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
--------
T
P
E
G
---
N
-
E
--
V
---------
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
------------------------
F
S
K
D
--
W
-----
R
------------
N
---------
S
------
T
T
P
L
T
E
A
E
A
A
L
N
H
-----------
N
----------
M
L
------
E
---------
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
-----
I
V
D
G
L
V
D
A
M
L
A
-
A
P
-
D
G
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
-
P
D
R
A
A
F
R
--
V
W
T
D
A
F
V
-
F
--
P
-----
D
D
P
A
Q
A
Q
T
A
M
--------
A
E
---------
M
S
---
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
-
G
E
D
L
L
S
A
L
V
R
T
S
D
E
-
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
-
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
--
L
D
-
G
A
V
E
E
M
L
R
Y
E
G
P
V
-
E
S
A
---
T
-
Y
--
R
F
P
V
E
P
V
D
L
-
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
-
D
T
--
A
-
G
H
L
A
F
-
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
-----
16
PsiBlast_PDB
74.38
35%
-120
- C5 -
2VZM
2
PIKC_STRVZ
A:
[48-424]
-------------------------------
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
--------
T
P
E
G
---
N
-
E
--
V
---------
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
------------------------
F
S
K
D
--
W
-----
R
------------
N
---------
S
------
T
T
P
L
T
E
A
E
A
A
L
N
H
-----------
N
----------
M
L
------
E
---------
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
-----
I
V
D
G
L
V
D
A
M
L
A
-
A
P
-
D
G
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
-
P
D
R
A
A
F
R
--
V
W
T
D
A
F
V
-
F
--
P
-----
D
D
P
A
Q
A
Q
T
A
M
--------
A
E
---------
M
S
---
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
-
G
E
D
L
L
S
A
L
V
R
T
S
D
E
-
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
-
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
--
L
D
-
G
A
V
E
E
M
L
R
Y
E
G
P
V
-
E
S
A
---
T
-
Y
--
R
F
P
V
E
P
V
D
L
-
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
-
D
T
--
A
-
G
H
L
A
F
-
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
-----
46
PsiBlast_CBE
74.35
35%
-118
- C5 -
2VZM
2
PIKC_STRVZ
B:
[48-424]
-------------------------------
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
--------
T
P
E
G
---
N
-
E
--
V
---------
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
------------------------
F
S
K
D
--
W
-----
R
------------
N
---------
S
------
T
T
P
L
T
E
A
E
A
A
L
N
H
-----------
N
----------
M
L
------
E
---------
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
-----
I
V
D
G
L
V
D
A
M
L
A
-
A
P
-
D
G
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
-
P
D
R
A
A
F
R
--
V
W
T
D
A
F
V
-
F
--
P
-----
D
D
P
A
Q
A
Q
T
A
M
--------
A
E
---------
M
S
---
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
-
G
E
D
L
L
S
A
L
V
R
T
S
D
E
-
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
-
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
--
L
D
-
G
A
V
E
E
M
L
R
Y
E
G
P
V
-
E
S
A
---
T
-
Y
--
R
F
P
V
E
P
V
D
L
-
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
-
D
T
--
A
-
G
H
L
A
F
-
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
-----
19
PsiBlast_PDB
74.33
35%
-115
- C5 -
3ZPI
13
PIKC_STRVZ
A:
[48-424]
-------------------------------
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
--------
T
P
E
G
---
N
-
E
--
V
---------
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
------------------------
F
S
K
D
--
W
-----
R
------------
N
---------
S
------
T
T
P
L
T
E
A
E
A
A
L
N
H
-----------
N
----------
M
L
------
E
---------
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
-----
I
V
D
G
L
V
D
A
M
L
A
-
A
P
-
D
G
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
-
P
D
R
A
A
F
R
--
V
W
T
D
A
F
V
-
F
--
P
-----
D
D
P
A
Q
A
Q
T
A
M
--------
A
E
---------
M
S
---
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
-
G
E
D
L
L
S
A
L
V
R
T
S
D
E
-
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
-
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
--
L
D
-
G
A
V
E
E
M
L
R
Y
E
G
P
V
-
E
S
A
---
T
-
Y
--
R
F
P
V
E
P
V
D
L
-
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
-
D
T
--
A
-
G
H
L
A
F
-
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
-----
26
PsiBlast_CBE
74.28
35%
-116
- C5 -
4UMZ
2
PIKC_STRVZ
B:
[48-424]
-------------------------------
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
--------
T
P
E
G
---
N
-
E
--
V
---------
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
------------------------
F
S
K
D
--
W
-----
R
------------
N
---------
S
------
T
T
P
L
T
E
A
E
A
A
L
N
H
-----------
N
----------
M
L
------
E
---------
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
-----
I
V
D
G
L
V
D
A
M
L
A
-
A
P
-
D
G
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
-
P
D
R
A
A
F
R
--
V
W
T
D
A
F
V
-
F
--
P
-----
D
D
P
A
Q
A
Q
T
A
M
--------
A
E
---------
M
S
---
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
-
G
E
D
L
L
S
A
L
V
R
T
S
D
E
-
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
-
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
--
L
D
-
G
A
V
E
E
M
L
R
Y
E
G
P
V
-
E
S
A
---
T
-
Y
--
R
F
P
V
E
P
V
D
L
-
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
-
D
T
--
A
-
G
H
L
A
F
-
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
-----
90
PsiBlast_CBE
74.27
34%
-128
- C5 -
3VRM
2
CPVDH_PSEAH
A:
[22-398]
-------------------------------
P
H
P
A
Y
A
A
L
R
A
E
D
P
---
V
R
--------
K
L
A
L
---
P
-
D
G
P
V
---------
W
L
L
T
R
Y
A
D
V
R
E
A
F
V
D
P
R
------------------------
L
S
K
D
--
W
-----
R
HTLPEDQRADMP
A
---------
T
------
P
T
----------
P
-----------
M
----------
M
I
------
L
---------
M
D
P
P
D
H
T
R
L
R
K
L
V
G
R
S
F
A
V
R
R
M
N
E
L
E
P
R
I
T
E
-----
I
A
D
G
L
L
A
G
--
L
-
P
T
-
D
G
P
V
D
L
M
R
E
Y
A
F
Q
I
P
V
Q
V
I
C
E
L
L
G
V
P
A
-
E
D
R
D
D
F
S
--
A
W
S
S
V
L
V
-
D
D
S
P
-----
A
D
D
K
N
A
A
M
G
K
L
H
G
----------------------
Y
L
S
D
L
L
E
R
K
R
T
E
P
-
D
D
A
L
L
S
S
L
L
A
V
S
D
E
-
D
G
D
R
L
S
Q
E
E
L
V
A
M
A
M
L
L
L
I
A
G
H
E
T
T
V
N
L
I
G
N
G
V
-
L
A
L
L
T
H
P
D
Q
R
K
L
L
A
E
D
P
S
L
--
I
S
-
S
A
V
E
E
F
L
R
F
D
S
P
V
S
Q
-
A
---
P
-
I
--
R
F
T
A
E
D
V
T
Y
-
S
G
V
T
I
P
A
G
E
M
V
M
L
G
L
A
A
A
N
R
D
A
D
W
M
P
E
P
D
R
L
D
I
T
R
-
D
A
--
S
-
G
G
V
F
F
-
G
H
G
I
H
F
C
L
G
A
Q
L
A
R
L
E
G
R
V
A
I
G
R
L
F
A
D
R
P
E
L
A
L
A
V
G
L
D
E
L
V
Y
R
E
S
T
L
V
R
G
L
S
R
M
P
V
T
M
----
14
PsiBlast_PDB
74.17
35%
-119
- C5 -
2WI9
2
PIKC_STRVZ
A:
[48-424]
-------------------------------
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
--------
T
P
E
G
---
N
-
E
--
V
---------
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
------------------------
F
S
K
D
--
W
-----
R
------------
N
---------
S
------
T
T
P
L
T
E
A
E
A
A
L
N
H
-----------
N
----------
M
L
------
E
---------
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
-----
I
V
D
G
L
V
D
A
M
L
A
-
A
P
-
D
G
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
-
P
D
R
A
A
F
R
--
V
W
T
D
A
F
V
-
F
--
P
-----
D
D
P
A
Q
A
Q
T
A
M
--------
A
E
---------
M
S
---
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
-
G
E
D
L
L
S
A
L
V
R
T
S
D
E
-
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
-
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
--
L
D
-
G
A
V
E
E
M
L
R
Y
E
G
P
V
-
E
S
A
---
T
-
Y
--
R
F
P
V
E
P
V
D
L
-
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
-
D
T
--
A
-
G
H
L
A
F
-
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
-----
10
PsiBlast_PDB
74.17
38%
-117
- C5 -
2XFH
4
ERYK_SACEN
A:
[37-401]
--------------------------------------
M
R
E
K
Q
P
---
V
W
--------
Q
D
-
R
---
Y
-
G
--
V
---------
W
H
V
F
R
H
A
D
V
Q
T
V
L
R
D
T
A
------------------------
T
F
S
S
DP
T
-----
R
------------
V
---------
I
------
E
G
----------
A
-----------
S
PTPGM-----
I
H
------
E
---------
I
D
P
P
E
H
R
A
L
R
K
V
V
S
S
A
F
T
P
R
T
I
S
D
L
E
P
R
I
R
D
-----
V
T
R
S
L
L
A
D
--
A
-
G
E
---
S
F
D
L
V
D
V
L
A
F
P
L
P
V
T
I
V
A
E
L
L
G
L
P
P
-
M
D
H
E
Q
F
G
--
D
W
S
G
A
L
V
D
I
Q
M
D
-----
D
P
T
D
P
A
L
A
E
R
I
A
D
V
L
N
P
------------
L
T
---
A
Y
L
K
A
R
C
A
E
R
R
A
D
P
-
G
D
D
L
I
S
R
L
V
L
-
A
E
V
-
D
G
R
A
L
D
D
E
E
A
A
N
F
S
T
A
L
L
L
A
G
H
I
T
T
T
V
L
L
G
N
I
V
-
R
T
L
D
E
H
P
A
H
W
D
A
A
A
E
D
P
G
R
--
I
P
-
A
I
V
E
E
V
L
R
Y
R
P
P
F
-
P
-
Q
---
M
-
Q
--
R
T
T
T
K
A
T
E
V
-
A
G
V
P
I
P
A
D
V
M
V
N
T
W
V
L
S
A
N
R
D
S
D
A
H
D
D
P
D
R
F
D
P
S
R
-
K
S
GG
A
-
A
Q
L
S
F
-
G
H
G
V
H
F
C
L
G
A
P
L
A
R
L
E
N
R
V
A
L
E
E
I
I
A
R
F
G
R
L
T
V
D
R
D
D
E
R
L
R
H
F
E
Q
-
I
V
L
G
T
R
H
L
P
V
------
106
PsiBlast_CBE
74.14
32%
-123
- C5 -
4TRI
3
?
A:
[57-394]
--------------------------------------------------------------------------------------------
R
N
P
E
------------------------
L
F
S
S
--
T
-----
G
------------
G
---------
I
------
R
P
----------
D
-----------
Q
PGMPY-----
M
I
------
D
---------
M
D
D
P
Q
H
L
L
R
R
K
L
V
N
A
G
F
T
R
K
R
V
M
D
K
V
D
S
I
G
R
-----
L
C
D
T
L
I
D
A
--
V
-
C
E
-
R
G
E
C
D
F
V
R
D
I
A
A
P
L
P
M
A
V
I
G
D
M
L
G
V
L
P
-
T
E
R
D
M
L
L
--
K
W
S
D
D
L
V
-
C
G
L
S
-----
S
H
V
D
E
A
A
---
I
Q
K
L
M
D
T
F
A
A
---------
Y
T
---
E
F
T
K
D
V
I
T
K
R
R
A
E
P
-
T
D
D
L
F
S
V
L
V
N
-
S
E
V
-
E
G
Q
R
M
S
D
D
E
I
V
F
E
T
L
L
I
L
I
G
G
D
E
T
T
R
H
T
L
S
G
G
T
-
E
Q
L
L
R
H
R
D
Q
W
D
A
L
V
A
D
V
D
L
--
L
P
-
G
A
I
E
E
M
L
R
W
T
S
P
V
-
K
-
N
---
M
-
C
--
R
T
L
T
A
D
T
V
F
-
H
G
T
E
L
R
A
G
E
K
I
M
L
M
F
E
S
A
N
F
D
E
S
V
F
G
D
P
D
N
F
R
I
D
R
-
N
P
--
N
-
S
H
V
A
F
-
G
F
G
T
H
F
C
L
G
N
Q
L
A
R
L
E
L
R
L
M
T
E
R
V
L
R
R
L
P
D
L
-
R
L
A
D
D
A
P
V
P
L
R
P
A
N
F
V
S
G
P
E
S
M
P
V
V
F
T
---
24
PsiBlast_CBE
73.93
35%
-115
- C5 -
2WI9
5
PIKC_STRVZ
B:
[48-424]
-------------------------------
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
--------
T
P
E
G
---
N
-
E
--
V
---------
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
------------------------
F
S
K
D
--
W
-----
R
------------
N
---------
S
------
T
T
P
L
T
E
A
E
A
A
L
N
H
-----------
N
----------
M
L
------
E
---------
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
-----
I
V
D
G
L
V
D
A
M
L
A
-
A
P
-
D
G
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
-
P
D
R
A
A
F
R
--
V
W
T
D
A
F
V
-
F
--
P
-----
D
D
P
A
Q
A
Q
T
A
M
--------
A
E
---------
M
S
---
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
-
G
E
D
L
L
S
A
L
V
R
T
S
D
E
-
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
-
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
--
L
D
-
G
A
V
E
E
M
L
R
Y
E
G
P
V
-
E
S
A
---
T
-
Y
--
R
F
P
V
E
P
V
D
L
-
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
-
D
T
--
A
-
G
H
L
A
F
-
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
-----
66
PsiBlast_CBE
73.91
35%
-119
- C5 -
2C7X
2
PIKC_STRVZ
A:
[48-424]
-------------------------------
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
--------
T
P
E
G
---
D
-
E
--
V
---------
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
------------------------
F
S
K
D
--
W
-----
R
------------
N
---------
S
------
T
T
P
L
T
E
A
E
A
A
L
N
H
-----------
N
----------
M
L
------
E
---------
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
-----
I
V
D
G
L
V
D
A
M
L
A
-
A
P
-
D
G
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
-
P
D
R
A
A
F
R
--
V
W
T
D
A
F
V
-
F
--
P
-----
D
D
P
A
Q
A
Q
T
A
M
--------
A
E
---------
M
S
---
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
-
G
E
D
L
L
S
A
L
V
R
T
S
D
E
-
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
-
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
--
L
D
-
G
A
V
E
E
M
L
R
Y
E
G
P
V
-
E
S
A
---
T
-
Y
--
R
F
P
V
E
P
V
D
L
-
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
-
D
T
--
A
-
G
H
L
A
F
-
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
-----
8
PsiBlast_PDB
73.87
38%
-122
- C5 -
2JJO
2
ERYK_SACEN
A:
[37-401]
--------------------------------------
M
R
E
K
Q
P
---
V
W
--------
Q
D
-
R
---
Y
-
G
--
V
---------
W
H
V
F
R
H
A
D
V
Q
T
V
L
R
D
T
A
------------------------
T
F
S
S
DP
T
-----
R
------------
V
---------
I
------
E
G
----------
A
-----------
S
PTPGM-----
I
H
------
E
---------
I
D
P
P
E
H
R
A
L
R
K
V
V
S
S
A
F
T
P
R
T
I
S
D
L
E
P
R
I
R
D
-----
V
T
R
S
L
L
A
D
--
A
-
G
E
---
S
F
D
L
V
D
V
L
A
F
P
L
P
V
T
I
V
A
E
L
L
G
L
P
P
-
M
D
H
E
Q
F
G
--
D
W
S
G
A
L
V
D
I
Q
M
D
-----
D
P
T
D
P
A
L
A
E
R
I
A
D
V
L
N
P
------------
L
T
---
A
Y
L
K
A
R
C
A
E
R
R
A
D
P
-
G
D
D
L
I
S
R
L
V
L
-
A
E
V
-
D
G
R
A
L
D
D
E
E
A
A
N
F
S
T
A
L
L
L
A
G
H
I
T
T
T
V
L
L
G
N
I
V
-
R
T
L
D
E
H
P
A
H
W
D
A
A
A
E
D
P
G
R
--
I
P
-
A
I
V
E
E
V
L
R
Y
R
P
P
F
-
P
-
Q
---
M
-
Q
--
R
T
T
T
K
A
T
E
V
-
A
G
V
P
I
P
A
D
V
M
V
N
T
W
V
L
S
A
N
R
D
S
D
A
H
D
D
P
D
R
F
D
P
S
R
-
K
S
GG
A
-
A
Q
L
S
F
-
G
H
G
V
H
F
C
L
G
A
P
L
A
R
L
E
N
R
V
A
L
E
E
I
I
A
R
F
G
R
L
T
V
D
R
D
D
E
R
L
R
H
F
E
Q
-
I
V
L
G
T
R
H
L
P
V
------
45
PsiBlast_CBE
73.84
35%
-119
- C5 -
3ZK5
2
PIKC_STRVZ
B:
[48-424]
-------------------------------
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
--------
T
P
E
G
---
N
-
E
--
V
---------
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
------------------------
F
S
K
D
--
W
-----
R
------------
N
---------
S
------
T
T
P
L
T
E
A
E
A
A
L
N
H
-----------
N
----------
M
L
------
E
---------
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
-----
I
V
D
G
L
V
D
A
M
L
A
-
A
P
-
D
G
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
-
P
D
R
A
A
F
R
--
V
W
T
D
A
F
V
-
F
--
P
-----
D
D
P
A
Q
A
Q
T
A
M
--------
A
E
---------
M
S
---
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
-
G
E
D
L
L
S
A
L
V
R
T
S
D
E
-
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
-
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
--
L
D
-
G
A
V
E
E
M
L
R
Y
E
G
P
V
-
E
S
A
---
T
-
Y
--
R
F
P
V
E
P
V
D
L
-
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
-
D
T
--
A
-
G
H
L
A
F
-
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
-----
27
PsiBlast_CBE
73.78
35%
-119
- C5 -
4UMZ
2
PIKC_STRVZ
A:
[48-424]
-------------------------------
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
--------
T
P
E
G
---
N
-
E
--
V
---------
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
------------------------
F
S
K
D
--
W
-----
R
------------
N
---------
S
------
T
T
P
L
T
E
A
E
A
A
L
N
H
-----------
N
----------
M
L
------
E
---------
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
-----
I
V
D
G
L
V
D
A
M
L
A
-
A
P
-
D
G
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
-
P
D
R
A
A
F
R
--
V
W
T
D
A
F
V
-
F
--
P
-----
D
D
P
A
Q
A
Q
T
A
M
--------
A
E
---------
M
S
---
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
-
G
E
D
L
L
S
A
L
V
R
T
S
D
E
-
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
-
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
--
L
D
-
G
A
V
E
E
M
L
R
Y
E
G
P
V
-
E
S
A
---
T
-
Y
--
R
F
P
V
E
P
V
D
L
-
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
-
D
T
--
A
-
G
H
L
A
F
-
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
-----
100
PsiBlast_CBE
73.68
34%
-121
- C5 -
3A1L
2
?
A:
[16-394]
-------------------------
K
K
D
I
A
D
P
Y
P
V
Y
R
R
Y
R
E
A
A
P
---
V
H
R
T
A
-----
S
G
P
G
---
K
P
D
--
T
---------
Y
Y
V
F
T
Y
D
D
V
V
R
V
L
S
N
R
R
------------------------
L
G
R
N
--
A
-----
R
V
A
S
GDTDTAPV-
P
---------
I
------
P
T
----------
E
-----------
H
R
A
L
R
T
V
V
E
N
W
L
V
------
F
---------
L
D
P
P
H
H
T
E
L
R
S
L
L
T
T
E
F
S
P
S
I
V
T
G
L
R
P
R
I
A
E
-----
L
A
S
A
L
L
D
R
--
L
-
R
A
-
Q
R
R
P
D
L
V
E
G
F
A
A
P
L
P
I
L
V
I
S
A
L
L
G
I
P
E
-
E
D
H
T
W
L
R
--
A
N
A
---
V
-
A
L
Q
E
-----
A
S
T
T
R
A
--------
R
D
G
R
G
Y
A
R
A
E
A
A
S
Q
E
F
T
---
R
Y
F
R
R
E
V
D
R
R
G
G
D
D
-
R
D
D
L
L
T
L
L
V
R
-
A
R
D
-
T
G
S
P
L
S
V
D
G
I
V
G
T
C
V
H
L
L
T
A
G
H
E
T
T
T
N
F
L
A
K
A
V
-
L
T
L
R
A
H
R
D
V
L
D
E
L
R
T
T
P
E
S
--
T
P
-
A
A
V
E
E
L
M
R
Y
D
P
P
V
-
Q
-
A
---
V
-
T
--
R
W
A
Y
E
D
I
R
L
-
G
D
H
D
I
P
R
G
S
R
V
V
A
L
L
G
S
A
N
R
D
P
A
R
F
P
D
P
D
V
L
D
V
H
R
-
A
A
--
E
-
R
Q
V
G
F
-
G
L
G
I
H
Y
C
L
G
A
T
L
A
R
A
E
A
E
I
G
L
R
A
L
L
D
G
I
P
A
L
G
R
G
A
H
E
-------------------------
18
PsiBlast_PDB
73.66
35%
-114
- C5 -
3ZK5
2
PIKC_STRVZ
A:
[48-424]
-------------------------------
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
--------
T
P
E
G
---
N
-
E
--
V
---------
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
------------------------
F
S
K
D
--
W
-----
R
------------
N
---------
S
------
T
T
P
L
T
E
A
E
A
A
L
N
H
-----------
N
----------
M
L
------
E
---------
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
-----
I
V
D
G
L
V
D
A
M
L
A
-
A
P
-
D
G
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
-
P
D
R
A
A
F
R
--
V
W
T
D
A
F
V
-
F
--
P
-----
D
D
P
A
Q
A
Q
T
A
M
--------
A
E
---------
M
S
---
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
-
G
E
D
L
L
S
A
L
V
R
T
S
D
E
-
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
-
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
--
L
D
-
G
A
V
E
E
M
L
R
Y
E
G
P
V
-
E
S
A
---
T
-
Y
--
R
F
P
V
E
P
V
D
L
-
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
-
D
T
--
A
-
G
H
L
A
F
-
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
-----
47
PsiBlast_CBE
73.60
35%
-114
- C5 -
2VZ7
2
PIKC_STRVZ
B:
[48-424]
-------------------------------
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
--------
T
P
E
G
---
N
-
E
--
V
---------
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
------------------------
F
S
K
D
--
W
-----
R
------------
N
---------
S
------
T
T
P
L
T
E
A
E
A
A
L
N
H
-----------
N
----------
M
L
------
E
---------
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
-----
I
V
D
G
L
V
D
A
M
L
A
-
A
P
-
D
G
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
-
P
D
R
A
A
F
R
--
V
W
T
D
A
F
V
-
F
--
P
-----
D
D
P
A
Q
A
Q
T
A
M
--------
A
E
---------
M
S
---
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
-
G
E
D
L
L
S
A
L
V
R
T
S
D
E
-
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
-
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
--
L
D
-
G
A
V
E
E
M
L
R
Y
E
G
P
V
-
E
S
A
---
T
-
Y
--
R
F
P
V
E
P
V
D
L
-
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
-
D
T
--
A
-
G
H
L
A
F
-
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
-----
67
PsiBlast_CBE
73.49
35%
-117
- C5 -
2C6H
3
PIKC_STRVZ
B:
[48-424]
-------------------------------
P
Y
P
T
Y
A
R
L
R
A
E
G
P
AHR
V
R
--------
T
P
E
G
---
D
-
E
--
V
---------
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
------------------------
F
S
K
D
--
W
-----
R
------------
N
---------
S
------
T
T
PLTEAEAALN
H
-----------
N
----------
M
L
------
E
---------
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
-----
I
V
D
G
L
V
D
A
ML
A
-
A
P
-
D
G
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
-
P
D
R
A
A
F
R
--
V
W
T
D
A
F
V
-
F
--
P
-----
D
D
P
A
Q
A
Q
T
A
M
--------
A
E
---------
M
S
---
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
-
G
E
D
L
L
S
A
L
V
R
T
S
D
E
-
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
-
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
--
L
D
-
G
A
V
E
E
M
L
R
Y
E
G
P
V
-
E
S
A
---
T
-
Y
--
R
F
P
V
E
P
V
D
L
-
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
-
D
T
--
A
-
G
H
L
A
F
-
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
-----
63
PsiBlast_CBE
73.35
35%
-114
- C5 -
2CD8
2
PIKC_STRVZ
A:
[48-424]
-------------------------------
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
--------
T
P
E
G
---
D
-
E
--
V
---------
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
------------------------
F
S
K
D
--
W
-----
R
------------
N
---------
S
------
T
T
P
L
T
E
A
E
A
A
L
N
H
-----------
N
----------
M
L
------
E
---------
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
-----
I
V
D
G
L
V
D
A
M
L
A
-
A
P
-
D
G
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
-
P
D
R
A
A
F
R
--
V
W
T
D
A
F
V
-
F
--
P
-----
D
D
P
A
Q
A
Q
T
A
M
--------
A
E
---------
M
S
---
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
-
G
E
D
L
L
S
A
L
V
R
T
S
D
E
-
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
-
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
--
L
D
-
G
A
V
E
E
M
L
R
Y
E
G
P
V
-
E
S
A
---
T
-
Y
--
R
F
P
V
E
P
V
D
L
-
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
-
D
T
--
A
-
G
H
L
A
F
-
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
-----
25
PsiBlast_CBE
73.32
35%
-116
- C5 -
2WHW
4
PIKC_STRVZ
B:
[48-424]
-------------------------------
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
--------
T
P
E
G
---
N
-
E
--
V
---------
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
------------------------
F
S
K
D
--
W
-----
R
------------
N
---------
S
------
T
T
P
L
T
E
A
E
A
A
L
N
H
-----------
N
----------
M
L
------
E
---------
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
-----
I
V
D
G
L
V
D
A
M
L
A
-
A
P
-
D
G
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
-
P
D
R
A
A
F
R
--
V
W
T
D
A
F
V
-
F
--
P
-----
D
D
P
A
Q
A
Q
T
A
M
--------
A
E
---------
M
S
---
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
-
G
E
D
L
L
S
A
L
V
R
T
S
D
E
-
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
-
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
--
L
D
-
G
A
V
E
E
M
L
R
Y
E
G
P
V
-
E
S
A
---
T
-
Y
--
R
F
P
V
E
P
V
D
L
-
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
-
D
T
--
A
-
G
H
L
A
F
-
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
-----
60
PsiBlast_CBE
73.28
35%
-114
- C5 -
4B7D
4
PIKC_STRVZ
B:
[48-424]
-------------------------------
P
Y
P
T
Y
A
R
L
R
A
E
G
P
AHR
V
R
--------
T
P
E
G
---
D
-
E
--
V
---------
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
------------------------
F
S
K
D
--
W
-----
R
------------
N
---------
S
------
T
T
PLTEAEAALN
H
-----------
N
----------
M
L
------
E
---------
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
-----
I
V
D
G
L
V
D
A
ML
A
-
A
P
-
D
G
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
-
P
D
R
A
A
F
R
--
V
W
T
D
A
F
V
-
F
--
P
-----
D
D
P
A
Q
A
Q
T
A
M
--------
A
E
---------
M
S
---
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
-
G
E
D
L
L
S
A
L
V
R
T
S
D
E
-
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
-
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
--
L
D
-
G
A
V
E
E
M
L
R
Y
E
G
P
V
-
E
S
A
---
T
-
Y
--
R
F
P
V
E
P
V
D
L
-
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
-
D
T
--
A
-
G
H
L
A
F
-
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
-----
13
PsiBlast_PDB
73.26
35%
-119
- C5 -
2WHW
2
PIKC_STRVZ
A:
[48-424]
-------------------------------
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
--------
T
P
E
G
---
N
-
E
--
V
---------
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
------------------------
F
S
K
D
--
W
-----
R
------------
N
---------
S
------
T
T
P
L
T
E
A
E
A
A
L
N
H
-----------
N
----------
M
L
------
E
---------
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
-----
I
V
D
G
L
V
D
A
M
L
A
-
A
P
-
D
G
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
-
P
D
R
A
A
F
R
--
V
W
T
D
A
F
V
-
F
--
P
-----
D
D
P
A
Q
A
Q
T
A
M
--------
A
E
---------
M
S
---
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
-
G
E
D
L
L
S
A
L
V
R
T
S
D
E
-
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
-
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
--
L
D
-
G
A
V
E
E
M
L
R
Y
E
G
P
V
-
E
S
A
---
T
-
Y
--
R
F
P
V
E
P
V
D
L
-
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
-
D
T
--
A
-
G
H
L
A
F
-
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
-----
43
PsiBlast_CBE
73.22
35%
-117
- C5 -
4B7S
6
PIKC_STRVZ
B:
[48-424]
-------------------------------
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
--------
T
P
E
G
---
N
-
E
--
V
---------
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
------------------------
F
S
K
D
--
W
-----
R
------------
N
---------
S
------
T
T
P
L
T
E
A
E
A
A
L
N
H
-----------
N
----------
M
L
------
E
---------
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
-----
I
V
D
G
L
V
D
A
M
L
A
-
A
P
-
D
G
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
-
P
D
R
A
A
F
R
--
V
W
T
D
A
F
V
-
F
--
P
-----
D
D
P
A
Q
A
Q
T
A
M
--------
A
E
---------
M
S
---
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
-
G
E
D
L
L
S
A
L
V
R
T
S
D
E
-
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
-
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
--
L
D
-
G
A
V
E
E
M
L
R
Y
E
G
P
V
-
E
S
A
---
T
-
Y
--
R
F
P
V
E
P
V
D
L
-
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
-
D
T
--
A
-
G
H
L
A
F
-
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
-----
68
PsiBlast_CBE
73.18
35%
-117
- C5 -
2C6H
6
PIKC_STRVZ
A:
[48-424]
-------------------------------
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
--------
T
P
E
G
---
D
-
E
--
V
---------
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
------------------------
F
S
K
D
--
W
-----
R
------------
N
---------
S
------
T
T
P
L
T
E
A
E
A
A
L
N
H
-----------
N
----------
M
L
------
E
---------
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
-----
I
V
D
G
L
V
D
A
M
L
A
-
A
P
-
D
G
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
-
P
D
R
A
A
F
R
--
V
W
T
D
A
F
V
-
F
--
P
-----
D
D
P
A
Q
A
Q
T
A
M
--------
A
E
---------
M
S
---
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
-
G
E
D
L
L
S
A
L
V
R
T
S
D
E
-
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
-
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
--
L
D
-
G
A
V
E
E
M
L
R
Y
E
G
P
V
-
E
S
A
---
T
-
Y
--
R
F
P
V
E
P
V
D
L
-
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
-
D
T
--
A
-
G
H
L
A
F
-
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
-----
15
PsiBlast_PDB
73.17
35%
-120
- C5 -
2VZ7
2
PIKC_STRVZ
A:
[48-424]
-------------------------------
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
--------
T
P
E
G
---
N
-
E
--
V
---------
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
------------------------
F
S
K
D
--
W
-----
R
------------
N
---------
S
------
T
T
P
L
T
E
A
E
A
A
L
N
H
-----------
N
----------
M
L
------
E
---------
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
-----
I
V
D
G
L
V
D
A
M
L
A
-
A
P
-
D
G
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
-
P
D
R
A
A
F
R
--
V
W
T
D
A
F
V
-
F
--
P
-----
D
D
P
A
Q
A
Q
T
A
M
--------
A
E
---------
M
S
---
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
-
G
E
D
L
L
S
A
L
V
R
T
S
D
E
-
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
-
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
--
L
D
-
G
A
V
E
E
M
L
R
Y
E
G
P
V
-
E
S
A
---
T
-
Y
--
R
F
P
V
E
P
V
D
L
-
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
-
D
T
--
A
-
G
H
L
A
F
-
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
-----
110
Fugue
73.04
38%
-119
- C5 -
1IO7
1
CP119_SULAC
A:
[1-366]
-----------------------------
M
--
Y
D
W
F
S
E
M
R
K
K
D
P
---
V
Y
--------
Y
D
G
------
N
--
I
---------
W
Q
V
F
S
Y
R
Y
T
K
E
V
L
N
--
N
FSKFSSDLTGYHER
L
E
D
L
R
N
GKIR------
F
-----
D
------------
I
---------
P
------
T
R
----------
Y
-----------
T
----------
M
L
------
T
---------
S
D
P
P
L
H
D
E
L
R
S
M
S
A
D
I
F
S
P
Q
K
L
Q
T
L
E
T
F
I
R
E
-----
T
T
R
S
L
L
D
S
--
I
-
D
P
--
R
E
D
D
I
V
K
K
L
A
V
P
L
P
I
I
V
I
S
K
I
L
G
L
P
-I
E
D
K
E
K
F
K
--
E
W
S
D
L
V
A
-
F
R
L
G
-----
K
------
P
G
E
I
F
E
L
G
K
K
Y
L
E
---------
L
I
---
G
Y
V
K
D
H
L
N
-----
S
G-
T
E
V
V
S
R
V
V
N
-
S
------
N
L
S
D
I
E
K
L
G
Y
I
I
L
L
L
I
A
G
N
E
T
T
T
N
L
I
S
N
S
V
-
I
D
F
T
R
F
N
-
L
W
Q
R
I
R
E
E
---NL
Y
L
-
K
A
I
E
E
A
L
R
Y
S
P
P
V
-
M
R
T
-----
V
--
R
K
T
K
E
R
V
K
L
G-
D
Q
T
I
E
E
G
E
Y
V
R
V
W
I
A
S
A
N
R
D
E
E
V
F
H
D
G
E
K
F
I
P
D
R
N-
P
--
N
-
P
H
L
S
F
-
G
S
G
I
H
L
C
L
G
A
P
L
A
R
L
E
A
R
I
A
I
E
E
F
S
K
R
F
R
H
I
E
I
L
D
----
T
E
K
V
P
N
E
V
L
N
G
Y
K
R
L
V
V
R
L
K
--S
99
PsiBlast_CBE
72.98
33%
-110
- C5 -
2WM4
3
CP124_MYCTU
A:
[50-432]
-----------------------------------
F
A
T
L
R
R
E
A
P
---
I
S
--------
F
W
P
T
---
I
-
E
--
L
PGFVA
G
N
G
H
W
A
L
T
K
Y
D
D
V
F
Y
A
S
R
H
P
D
------------------------
I
F
S
S
--
Y
-----
P
------------
N
---------
I
------
T
I
----------
N
DQT
P
E
L
A
E
YFG
S
----------
M
I
------
V
---------
L
D
D
P
R
H
Q
R
L
R
S
I
V
S
R
A
F
T
P
K
V
V
A
R
I
E
A
A
V
R
D
R
A
H
R
L
V
S
S
M
I
A
N
N
--
P
-
D
R
-
Q
A
--
D
L
V
S
E
L
A
G
P
L
P
L
Q
I
I
C
D
M
M
G
I
P
K
-
A
D
H
Q
R
I
F
--
H
W
T
N
V
I
L
-
G
---------
F
G
D
P
D
L
A
T
D
F
D
E
F
M
Q
V
S
A
D
---------
I
G
---
A
Y
A
T
A
L
A
E
D
R
R
V
N
H
-
H
D
D
L
T
S
S
L
V
E
-
A
E
V
-
D
G
E
R
L
S
S
R
E
I
A
S
F
F
I
L
L
V
V
A
G
N
E
T
T
R
N
A
I
T
H
G
V
-
L
A
L
S
R
Y
P
E
Q
R
D
R
W
W
S
D
F
D
G
--
L
A
P
T
A
V
E
E
I
V
R
W
A
S
P
V
-
V
-
Y
---
M
-
R
--
R
T
L
T
Q
D
I
E
L
-
R
G
T
K
M
A
A
G
D
K
V
S
L
W
Y
C
S
A
N
R
D
E
S
K
F
A
D
P
W
T
F
D
L
A
R
-
N
P
--
N
-
P
H
L
G
F
G
G
G
G
A
H
F
C
L
G
A
N
L
A
R
R
E
I
R
V
A
F
D
E
L
R
R
Q
---
M
P
D
V
V
A
T
E
E
P
A
R
L
L
S
Q
F
I
H
G
I
K
T
L
P
V
------
7
PsiBlast_PDB
72.95
38%
-114
- C5 -
2JJN
6
ERYK_SACEN
A:
[37-401]
--------------------------------------
M
R
E
K
Q
P
---
V
W
--------
Q
D
-
R
---
Y
-
G
--
V
---------
W
H
V
F
R
H
A
D
V
Q
T
V
L
R
D
T
A
------------------------
T
F
S
S
DP
T
-----
R
------------
V
---------
I
------
E
G
----------
A
-----------
S
P
T
P
GM-----
I
H
------
E
---------
I
D
P
P
E
H
R
A
L
R
K
V
V
S
S
A
F
T
P
R
T
I
S
D
L
E
P
R
I
R
D
-----
V
T
R
S
L
L
A
D
--
A
-
G
E
---
S
F
D
L
V
D
V
L
A
F
P
L
P
V
T
I
V
A
E
L
L
G
L
P
P
-
M
D
H
E
Q
F
G
--
D
W
S
G
A
L
V
D
I
Q
M
D
-----
D
P
T
D
P
A
L
A
E
R
I
A
D
V
L
N
P
------------
L
T
---
A
Y
L
K
A
R
C
A
E
R
R
A
D
P
-
G
D
D
L
I
S
R
L
V
L
-
A
E
V
-
D
G
R
A
L
D
D
E
E
A
A
N
F
S
T
A
L
L
L
A
G
H
I
T
T
T
V
L
L
G
N
I
V
-
R
T
L
D
E
H
P
A
H
W
D
A
A
A
E
D
P
G
R
--
I
P
-
A
I
V
E
E
V
L
R
Y
R
P
P
F
-
P
-
Q
---
M
-
Q
--
R
T
T
T
K
A
T
E
V
-
A
G
V
P
I
P
A
D
V
M
V
N
T
W
V
L
S
A
N
R
D
S
D
A
H
D
D
P
D
R
F
D
P
S
R
-
K
S
GG
A
-
A
Q
L
S
F
-
G
H
G
V
H
F
C
L
G
A
P
L
A
R
L
E
N
R
V
A
L
E
E
I
I
A
R
F
G
R
L
T
V
D
R
D
D
E
R
L
R
H
F
E
Q
-
I
V
L
G
T
R
H
L
P
V
------
62
PsiBlast_CBE
72.44
35%
-118
- C5 -
2CD8
2
PIKC_STRVZ
B:
[48-424]
-------------------------------
P
Y
P
T
Y
A
R
L
R
A
E
G
P
AHR
V
R
--------
T
P
E
G
---
D
-
E
--
V
---------
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
------------------------
F
S
K
D
--
W
-----
R
------------
N
---------
S
------
T
T
PLTEAEAALN
H
-----------
N
----------
M
L
------
E
---------
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
-----
I
V
D
G
L
V
D
A
ML
A
-
A
P
-
D
G
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
-
P
D
R
A
A
F
R
--
V
W
T
D
A
F
V
-
F
--
P
-----
D
D
P
A
Q
A
Q
T
A
M
--------
A
E
---------
M
S
---
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
-
G
E
D
L
L
S
A
L
V
R
T
S
D
E
-
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
-
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
--
L
D
-
G
A
V
E
E
M
L
R
Y
E
G
P
V
-
E
S
A
---
T
-
Y
--
R
F
P
V
E
P
V
D
L
-
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
-
D
T
--
A
-
G
H
L
A
F
-
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
-----
9
PsiBlast_PDB
72.44
38%
-118
- C5 -
2JJP
4
ERYK_SACEN
A:
[37-401]
--------------------------------------
M
R
E
K
Q
P
---
V
W
--------
Q
D
-
R
---
Y
-
G
--
V
---------
W
H
V
F
R
H
A
D
V
Q
T
V
L
R
D
T
A
------------------------
T
F
S
S
DP
T
-----
R
------------
V
---------
I
------
E
G
----------
A
-----------
S
PTPGM-----
I
H
------
E
---------
I
D
P
P
E
H
R
A
L
R
K
V
V
S
S
A
F
T
P
R
T
I
S
D
L
E
P
R
I
R
D
-----
V
T
R
S
L
L
A
D
--
A
-
G
E
---
S
F
D
L
V
D
V
L
A
F
P
L
P
V
T
I
V
A
E
L
L
G
L
P
P
-
M
D
H
E
Q
F
G
--
D
W
S
G
A
L
V
D
I
Q
M
D
-----
D
P
T
D
P
A
L
A
E
R
I
A
D
V
L
N
P
------------
L
T
---
A
Y
L
K
A
R
C
A
E
R
R
A
D
P
-
G
D
D
L
I
S
R
L
V
L
-
A
E
V
-
D
G
R
A
L
D
D
E
E
A
A
N
F
S
T
A
L
L
L
A
G
H
I
T
T
T
V
L
L
G
N
I
V
-
R
T
L
D
E
H
P
A
H
W
D
A
A
A
E
D
P
G
R
--
I
P
-
A
I
V
E
E
V
L
R
Y
R
P
P
F
-
P
-
Q
---
M
-
Q
--
R
T
T
T
K
A
T
E
V
-
A
G
V
P
I
P
A
D
V
M
V
N
T
W
V
L
S
A
N
R
D
S
D
A
H
D
D
P
D
R
F
D
P
S
R
-
K
S
GG
A
-
A
Q
L
S
F
-
G
H
G
V
H
F
C
L
G
A
P
L
A
R
L
E
N
R
V
A
L
E
E
I
I
A
R
F
G
R
L
T
V
D
R
D
D
E
R
L
R
H
F
E
Q
-
I
V
L
G
T
R
H
L
P
V
------
17
PsiBlast_PDB
72.16
35%
-115
- C5 -
4B7S
14
PIKC_STRVZ
A:
[48-424]
-------------------------------
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
--------
T
P
E
G
---
N
-
E
--
V
---------
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
------------------------
F
S
K
D
--
W
-----
R
------------
N
---------
S
------
T
T
P
L
T
E
A
E
A
A
L
N
H
-----------
N
----------
M
L
------
E
---------
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
-----
I
V
D
G
L
V
D
A
M
L
A
-
A
P
-
D
G
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
-
P
D
R
A
A
F
R
--
V
W
T
D
A
F
V
-
F
--
P
-----
D
D
P
A
Q
A
Q
T
A
M
--------
A
E
---------
M
S
---
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
-
G
E
D
L
L
S
A
L
V
R
T
S
D
E
-
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
-
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
--
L
D
-
G
A
V
E
E
M
L
R
Y
E
G
P
V
-
E
S
A
---
T
-
Y
--
R
F
P
V
E
P
V
D
L
-
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
-
D
T
--
A
-
G
H
L
A
F
-
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
-----
69
PsiBlast_CBE
72.07
35%
-117
- C5 -
2BVJ
2
PIKC_STRVZ
B:
[48-424]
-------------------------------
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
--------
T
P
E
G
---
D
-
E
--
V
---------
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
------------------------
F
S
K
D
--
W
-----
R
------------
N
---------
S
------
T
T
PLLN------
H
-----------
N
----------
M
L
------
E
---------
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
-----
I
V
D
G
L
V
D
A
M
L
A
-
A
P
-
D
G
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
-
P
D
R
A
A
F
R
--
V
W
T
D
A
F
V
-
F
--
P
-----
D
D
P
A
Q
A
Q
T
A
M
--------
A
E
---------
M
S
---
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
-
G
E
D
L
L
S
A
L
V
R
T
S
D
E
-
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
-
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
--
L
D
-
G
A
V
E
E
M
L
R
Y
E
G
P
V
-
E
S
A
---
T
-
Y
--
R
F
P
V
E
P
V
D
L
-
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
-
D
T
--
A
-
G
H
L
A
F
-
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
-----
104
PsiBlast_CBE
71.89
32%
-117
- C5 -
4UAX
1
?
A:
[57-394]
--------------------------------------------------------------------------------------------
R
N
P
E
------------------------
L
F
S
S
--
T
-----
G
------------
G
---------
I
------
R
P
----------
D
-----------
Q
PGMPY-----
M
I
------
D
---------
M
D
D
P
Q
H
L
L
R
R
K
L
V
N
A
G
F
T
R
K
R
V
M
D
K
V
D
S
I
G
R
-----
L
C
D
T
L
I
D
A
--
V
-
C
E
-
R
G
E
C
D
F
V
R
D
I
A
A
P
L
P
M
A
V
I
G
D
M
L
G
V
L
P
-
T
E
R
D
M
L
L
--
K
W
S
D
D
L
V
-
C
G
L
S
-----
S
H
V
D
E
A
A
---
I
Q
K
L
M
D
T
F
A
A
---------
Y
T
---
E
F
T
K
D
V
I
T
K
R
R
A
E
P
-
T
D
D
L
F
S
V
L
V
N
-
S
E
V
-
E
G
Q
R
M
S
D
D
E
I
V
F
E
T
L
L
I
L
I
G
G
D
E
T
T
R
H
T
L
S
G
G
T
-
E
Q
L
L
R
H
R
D
Q
W
D
A
L
V
A
D
V
D
L
--
L
P
-
G
A
I
E
E
M
L
R
W
T
S
P
V
-
K
-
N
---
M
-
C
--
R
T
L
T
A
D
T
V
F
-
H
G
T
E
L
R
A
G
E
K
I
M
L
M
F
E
S
A
N
F
D
E
S
V
F
G
D
P
D
N
F
R
I
D
R
-
N
P
--
N
-
S
H
V
A
F
-
G
F
G
T
H
F
C
L
G
N
Q
L
A
R
L
E
L
R
L
M
T
E
R
V
L
R
R
L
P
D
L
-
R
L
A
D
D
A
P
V
P
L
R
P
A
N
F
V
S
G
P
E
S
M
P
V
V
F
T
---
6
PsiBlast_PDB
71.80
38%
-118
- C5 -
2WIO
1
ERYK_SACEN
A:
[57-421]
--------------------------------------
M
R
E
K
Q
P
---
V
W
--------
Q
D
-
R
---
Y
-
G
--
V
---------
W
H
V
F
R
H
A
D
V
Q
T
V
L
R
D
T
A
------------------------
T
F
S
S
DP
T
-----
R
------------
V
---------
I
------
E
G
----------
A
-----------
S
PTPGM-----
I
H
------
E
---------
I
D
P
P
E
H
R
A
L
R
K
V
V
S
S
A
F
T
P
R
T
I
S
D
L
E
P
R
I
R
D
-----
V
T
R
S
L
L
A
D
--
A
-
G
E
---
S
F
D
L
V
D
V
L
A
F
P
L
P
V
T
I
V
A
E
L
L
G
L
P
P
-
M
D
H
E
Q
F
G
--
D
W
S
G
A
L
V
D
I
Q
M
D
-----
D
P
T
D
P
A
L
A
E
R
I
A
D
V
L
N
P
------------
L
T
---
A
Y
L
K
A
R
C
A
E
R
R
A
D
P
-
G
D
D
L
I
S
R
L
V
L
-
A
E
V
-
D
G
R
A
L
D
D
E
E
A
A
N
F
S
T
A
L
L
L
A
G
H
I
T
T
T
V
L
L
G
N
I
V
-
R
T
L
D
E
H
P
A
H
W
D
A
A
A
E
D
P
G
R
--
I
P
-
A
I
V
E
E
V
L
R
Y
R
P
P
F
-
P
-
Q
---
M
-
Q
--
R
T
T
T
K
A
T
E
V
-
A
G
V
P
I
P
A
D
V
M
V
N
T
W
V
L
S
A
N
R
D
S
D
A
H
D
D
P
D
R
F
D
P
S
R
-
K
S
GG
A
-
A
Q
L
S
F
-
G
H
G
V
H
F
C
L
G
A
P
L
A
R
L
E
N
R
V
A
L
E
E
I
I
A
R
F
G
R
L
T
V
D
R
D
D
E
R
L
R
H
F
E
Q
-
I
V
L
G
T
R
H
L
P
V
------
140
HHSearch
71.75
32%
-110
- C5 -
4WPZ
3
?
A:
[7-397]
-----------------------
P
D
P
P
S
V
-
E
L
P
P
E
L
A
E
I
R
D
G
Q
S
---
V
V
--------
E
V
K
F
PDG
I
-
S
--
G
---------
W
M
V
T
K
H
A
D
V
R
K
V
L
V
D
S
-------------------------
R
F
S
S
--
K
-----
V
-----------------------T
E
T
G
K
L
M
N
----------
E
-----------
S
----------
L
V
------
G
---------
M
D
A
P
E
H
T
R
L
R
K
L
V
T
K
A
F
T
A
R
R
V
E
T
L
R
P
R
I
T
E
-----
L
V
G
Q
L
L
D
E
--
L
-
E
T
L
P
R
P
V
D
L
V
K
N
F
S
V
P
L
P
V
R
V
I
C
E
L
L
G
V
P
A
-
G
D
Q
D
T
F
H
--
A
W
S
N
A
L
L
-
G
D
W
-------------
Q
Q
-
V
V
E
K
E
A
A
T
V
S
---------
L
V
---
N
Y
F
G
E
L
I
A
V
K
R
E
N
P
-
A
D
D
L
I
S
E
L
I
A
-
I
S
D
-
G
D
S
T
L
T
E
R
E
I
I
A
L
S
I
G
I
L
S
A
G
H
E
T
T
A
N
Q
I
S
M
F
L
-
V
T
L
L
H
N
P
E
E
L
D
K
L
R
D
N
R
E
A
--
I
P
-
K
A
V
D
E
L
L
R
F
V
P
L
T
-
T
-
T
GGI
I
-
P
--
R
L
T
T
A
E
V
E
L
S
G
G
Q
V
L
P
A
G
A
V
V
L
P
A
V
A
T
A
N
R
D
P
E
V
F
E
D
G
E
R
L
N
V
T
R
E
N
N
----
P
H
L
A
F
-
G
A
G
I
H
H
C
L
G
A
Q
L
A
R
I
E
L
Q
E
A
L
G
A
I
L
D
R
M
P
Q
V
R
L
A
V
P
E
S
E
L
R
L
K
S
A
S
I
I
R
G
L
E
S
L
P
I
T
W
----
98
PsiBlast_CBE
71.40
33%
-107
- C5 -
2WM5
1
CP124_MYCTU
A:
[50-432]
-----------------------------------
F
A
T
L
R
R
E
A
P
---
I
S
--------
F
W
P
T
---
I
-
E
--
L
VA
G
N
G
H
---
W
A
L
T
K
Y
D
D
V
F
Y
A
S
R
H
P
D
------------------------
I
F
S
S
--
Y
-----
P
------------
N
---------
I
------
T
I
----------
N
DQT
P
E
L
A
E
Y
F
G
S
----------
M
I
------
V
---------
L
D
D
P
R
H
Q
R
L
R
S
I
V
S
R
A
F
T
P
K
V
V
A
R
I
E
A
A
V
R
D
R
A
H
R
L
V
S
S
M
I
A
N
N
--
P
-
D
R
-
Q
A
--
D
L
V
S
E
L
A
G
P
L
P
L
Q
I
I
C
D
M
M
G
I
P
K
-
A
D
H
Q
R
I
F
--
H
W
T
N
V
I
L
-
G
---------
F
G
D
P
D
L
A
T
D
F
D
E
F
M
Q
V
S
A
D
---------
I
G
---
A
Y
A
T
A
L
A
E
D
R
R
V
N
H
-
H
D
D
L
T
S
S
L
V
E
-
A
E
V
-
D
G
E
R
L
S
S
R
E
I
A
S
F
F
I
L
L
V
V
A
G
N
E
T
T
R
N
A
I
T
H
G
V
-
L
A
L
S
R
Y
P
E
Q
R
D
R
W
W
S
D
F
D
G
--
L
A
P
T
A
V
E
E
I
V
R
W
A
S
P
V
-
V
-
Y
---
M
-
R
--
R
T
L
T
Q
D
I
E
L
-
R
G
T
K
M
A
A
G
D
K
V
S
L
W
Y
C
S
A
N
R
D
E
S
K
F
A
D
P
W
T
F
D
L
A
R
-
N
P
--
N
-
P
H
L
G
F
G
G
G
G
A
H
F
C
L
G
A
N
L
A
R
R
E
I
R
V
A
F
D
E
L
R
R
Q
---
M
P
D
V
V
A
T
E
E
P
A
R
L
L
S
Q
F
I
H
G
I
K
T
L
P
V
------
11
PsiBlast_PDB
70.86
36%
-124
- C5 -
3R9C
10
?
A:
[28-383]
----------------------------
R
A
D
P
Y
P
I
Y
D
R
I
R
R
G
G
P
---
L
A
L
PEAN
L
A
V
F
S
S
F
---
S
-
D
--
C
---------
D
D
V
L
R
H
P
S
S
C
S
D
R
T
K
S
T
------------------------
I
F
Q
R
--
Q
-----
L
------------
A
---------
A
------
E
T
----------
Q
PRPQGPA----
S
----------
F
L
------
F
---------
L
D
P
P
D
H
T
R
L
R
G
L
V
S
K
A
F
A
P
R
V
I
K
R
L
E
P
E
I
T
A
-----
L
V
D
Q
L
L
-
D
--
A
-
V
D
-
G
P
E
F
N
L
I
D
N
L
A
Y
P
L
P
V
A
V
I
C
R
L
L
G
V
P
I
-
E
D
E
P
K
F
S
R
A
S
A
L
L
A
A
A
-
L
D
P
F
-----
L
A
L
T
G
E
T
S
D
L
F
D
E
Q
M
K
A
G
M
W
---------
L
R
---
D
Y
L
R
A
L
I
D
E
R
R
R
T
P
-
G
E
D
L
M
S
G
L
V
A
-
V
E
E
-
S
G
D
Q
L
T
E
D
E
I
I
A
T
C
N
L
L
L
I
A
G
H
E
T
T
V
N
L
I
A
N
A
A
-
L
A
M
L
R
T
P
G
Q
W
A
A
L
A
A
D
G
S
R
--
A
S
-
A
V
I
E
E
T
M
R
Y
D
P
P
V
-
Q
-
L
---
V
-
S
--
R
Y
A
G
D
D
L
T
I
-
G
T
H
T
V
P
K
G
D
T
M
L
L
L
L
A
A
A
H
R
D
P
T
I
V
G
A
P
D
R
F
D
P
D
R
-
A
Q
--
I
-
R
H
L
G
F
-
G
K
G
A
H
F
C
L
G
A
P
L
A
R
L
E
A
T
V
A
L
P
A
L
--------------------------------------
65
PsiBlast_CBE
70.75
35%
-118
- C5 -
2CA0
2
PIKC_STRVZ
A:
[48-424]
-------------------------------
P
Y
P
T
Y
A
R
L
R
A
E
G
P
A
H
R
V
R
--------
T
P
E
G
---
D
-
E
--
V
---------
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
------------------------
F
S
K
D
--
W
-----
R
------------
N
---------
S
------
T
T
P
L
T
EAEAALN
H
-----------
N
----------
M
L
------
E
---------
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
-----
I
V
D
G
L
V
D
A
M
L
A
-
A
P
-
D
G
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
-
P
D
R
A
A
F
R
--
V
W
T
D
A
F
V
-
F
--
P
-----
D
D
P
A
Q
A
Q
T
A
M
--------
A
E
---------
M
S
---
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
-
G
E
D
L
L
S
A
L
V
R
T
S
D
E
-
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
-
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
--
L
D
-
G
A
V
E
E
M
L
R
Y
E
G
P
V
-
E
S
A
---
T
-
Y
--
R
F
P
V
E
P
V
D
L
-
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
-
D
T
--
A
-
G
H
L
A
F
-
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
-----
134
HHSearch
70.69
32%
-109
- C5 -
2XKR
2
CP142_MYCTU
A:
[11-393]
-------------------
D
G
N
F
Y
--
A
S
-
R
E
A
R
A
A
Y
R
W
M
R
A
N
Q
P
---
V
F
--------
R
D
R
N
-----
G
--
L
---------
A
A
A
S
T
Y
Q
A
V
I
D
A
E
R
Q
P
E
------------------------
L
F
S
N
--
A
-----
G
------------
G
---------
I
RPD
Q
P
-
A
L
----------
P
-----------
M
----------
M
I
------
D
---------
M
D
D
P
A
H
L
L
R
R
K
L
V
N
A
G
F
T
R
K
R
V
K
D
K
E
A
S
I
A
A
-----
L
C
D
T
L
I
D
A
--
V
-
C
E
-
R
G
E
C
D
F
V
R
D
L
A
A
P
L
P
M
A
V
I
G
D
M
L
G
V
R
P
-
E
Q
R
D
M
F
L
--
R
W
S
D
D
L
V
-
T
F
L
S
-----
S
H
V
S
---
Q
E
D
F
Q
I
T
M
D
A
F
A
A
---------
Y
N
---
D
F
T
R
A
T
I
A
A
R
R
A
D
P
-
T
D
D
L
V
S
V
L
V
S
-
S
E
V
-
D
G
E
R
L
S
D
D
E
L
V
M
E
T
L
L
I
L
I
G
G
D
E
T
T
R
H
T
L
S
G
G
T
-
E
Q
L
L
R
N
R
D
Q
W
D
L
L
Q
R
D
P
S
L
--
L
P
-
G
A
I
E
E
M
L
R
W
T
A
P
V
-
K
-
N
---
M
-
C
--
R
V
L
T
A
D
T
E
F
-
H
G
T
A
L
C
A
G
E
K
M
M
L
L
F
E
S
A
N
F
D
E
A
V
F
C
E
P
E
K
F
D
V
Q
R
N
P
N
----
S
H
L
A
F
-
G
F
G
T
H
F
C
L
G
N
Q
L
A
R
L
E
L
S
L
M
T
E
R
V
L
R
R
L
P
D
L
R
L
V
A
D
D
S
V
L
P
L
R
P
A
N
F
V
S
G
L
E
S
M
P
V
V
F
T
P
--
97
PsiBlast_CBE
70.30
37%
-130
- C5 -
2RFB
4
?
A:
[3-314]
----------------------------------------
L
N
D
P
---
V
H
--------
Y
D
G
---------
A
---------
W
H
V
Y
K
Y
S
D
V
K
H
V
L
M
N
D
K
------------------------
I
F
S
S
--
N
-----
P
------------
G
---------
N
------
R
Y
----------
S
GI---------
S
----------
F
I
------
T
---------
M
D
N
P
E
H
K
E
F
R
D
I
S
A
P
Y
F
L
P
S
K
I
N
D
Y
K
D
F
I
E
E
-----
T
S
N
D
L
I
K
N
--
I
-
D
N
-
K
---
D
I
I
S
E
Y
A
V
R
L
P
V
N
I
I
S
K
I
L
G
I
P
D
-
S
D
M
P
L
F
K
--
L
W
S
D
Y
I
I
-
G
N
K
R
-----
D
E
N
F
N
Y
V
N
N
R
M
V
S
R
---------------
L
L
---
E
I
F
K
--------
S
D
-
S
H
G
I
I
N
V
L
A
G
-
S
S
L
-
K
N
R
K
L
T
M
D
E
K
I
K
Y
I
M
L
L
I
I
G
G
N
E
T
T
T
N
L
I
G
N
M
I
-
R
V
I
D
E
N
P
D
I
I
D
D
A
L
K
N
R
-----
S
-
G
F
V
E
E
T
L
R
Y
Y
S
P
I
-
Q
-
F
---
L
P
H
--
R
F
A
A
E
D
S
Y
I
-
N
N
K
K
I
K
K
G
D
Q
V
I
V
Y
L
G
S
A
N
R
D
E
T
F
F
D
E
P
D
L
F
K
I
G
R
-
R
E
--
M
--
H
L
A
F
-
G
I
G
I
H
M
C
L
G
A
P
L
A
R
L
E
A
S
I
A
L
N
D
I
L
N
------------------------------------
64
PsiBlast_CBE
70.22
35%
-107
- C5 -
2CA0
2
PIKC_STRVZ
B:
[48-424]
-------------------------------
P
Y
P
T
Y
A
R
L
R
A
E
G
P
AHR
V
R
--------
T
P
E
G
---
D
-
E
--
V
---------
W
L
V
V
G
Y
D
R
A
R
A
V
L
A
D
P
R
------------------------
F
S
K
D
--
W
-----
R
------------
N
---------
S
------
T
T
PLTEAEAALN
H
-----------
N
----------
M
L
------
E
---------
S
D
P
P
R
H
T
R
L
R
K
L
V
A
R
E
F
T
M
R
R
V
E
L
L
R
P
R
V
Q
E
-----
I
V
D
G
L
V
D
A
ML
A
-
A
P
-
D
G
R
A
D
L
M
E
S
L
A
W
P
L
P
I
T
V
I
S
E
L
L
G
V
P
E
-
P
D
R
A
A
F
R
--
V
W
T
D
A
F
V
-
F
--
P
-----
D
D
P
A
Q
A
Q
T
A
M
--------
A
E
---------
M
S
---
G
Y
L
S
R
L
I
D
S
K
R
G
Q
D
-
G
E
D
L
L
S
A
L
V
R
T
S
D
E
-
D
G
S
R
L
T
S
E
E
L
L
G
M
A
H
I
L
L
V
A
G
H
E
T
T
V
N
L
I
A
N
G
M
-
Y
A
L
L
S
H
P
D
Q
L
A
A
L
R
A
D
M
T
L
--
L
D
-
G
A
V
E
E
M
L
R
Y
E
G
P
V
-
E
S
A
---
T
-
Y
--
R
F
P
V
E
P
V
D
L
-
D
G
T
V
I
P
A
G
D
T
V
L
V
V
L
A
D
A
H
R
T
P
E
R
F
P
D
P
H
R
F
D
I
R
R
-
D
T
--
A
-
G
H
L
A
F
-
G
H
G
I
H
F
C
I
G
A
P
L
A
R
L
E
A
R
I
A
V
R
A
L
L
E
R
C
P
D
L
A
L
D
V
S
P
G
E
L
V
W
Y
P
N
P
M
I
R
G
L
K
A
L
P
I
R
-----
95
PsiBlast_CBE
68.51
37%
-136
- C5 -
2RFB
2
?
C:
[3-314]
----------------------------------------
L
N
D
P
---
V
H
--------
Y
D
G
---------
A
---------
W
H
V
Y
K
Y
S
D
V
K
H
V
L
M
N
D
K
------------------------
I
F
S
S
--
N
------------------------------------------------GGI--------
S
----------
F
I
------
T
---------
M
D
N
P
E
H
K
E
F
R
D
I
S
A
P
Y
F
L
P
S
K
I
N
D
Y
K
D
F
I
E
E
-----
T
S
N
D
L
I
K
N
--
I
-
D
N
-
K
---
D
I
I
S
E
Y
A
V
R
L
P
V
N
I
I
S
K
I
L
G
I
P
D
-
S
D
M
P
L
F
K
--
L
W
S
D
Y
I
I
-
G
N
K
R
-----
D
E
N
F
N
Y
V
N
N
R
M
V
S
R
---------------
L
L
---
E
I
F
K
--------
S
D
-
S
H
G
I
I
N
V
L
A
G
-
S
S
L
-
K
N
R
K
L
T
M
D
E
K
I
K
Y
I
M
L
L
I
I
G
G
N
E
T
T
T
N
L
I
G
N
M
I
-
R
V
I
D
E
N
P
D
I
I
D
D
A
L
K
N
R
-----
S
-
G
F
V
E
E
T
L
R
Y
Y
S
P
I
-
Q
-
F
---
L
P
H
--
R
F
A
A
E
D
S
Y
I
-
N
N
K
K
I
K
K
G
D
Q
V
I
V
Y
L
G
S
A
N
R
D
E
T
F
F
D
E
P
D
L
F
K
I
G
R
-
R
E
--
M
--
H
L
A
F
-
G
I
G
I
H
M
C
L
G
A
P
L
A
R
L
E
A
S
I
A
L
N
D
I
L
N
------------------------------------
23
PsiBlast_CBE
67.41
36%
-122
- C5 -
3R9B
11
?
B:
[28-383]
----------------------------
R
A
D
P
Y
P
I
Y
D
R
I
R
R
G
G
P
---
L
A
LPEANLAV
F
S
S
F
---
S
-
D
--
C
---------
D
D
V
L
R
H
P
S
S
C
S
D
R
T
K
S
T
------------------------
I
F
Q
R
--
Q
-----
L
------------
A
-----------------------------PA---------
S
----------
F
L
------
F
---------
L
D
P
P
D
H
T
R
L
R
G
L
V
S
K
A
F
A
P
R
V
I
K
R
L
E
P
E
I
T
A
-----
L
V
D
Q
L
L
-
D
--
A
-
V
D
-
G
P
E
F
N
L
I
D
N
L
A
Y
P
L
P
V
A
V
I
C
R
L
L
G
V
P
I
-
E
D
E
P
K
F
S
RA
S
A
L
L
A
A
A
-
L
D
P
F
-----
L
A
L
T
G
E
T
S
D
L
F
D
E
Q
M
K
A
G
M
W
---------
L
R
---
D
Y
L
R
A
L
I
D
E
R
R
R
T
P
-
G
E
D
L
M
S
G
L
V
A
-
V
E
E
-
S
G
D
Q
L
T
E
D
E
I
I
A
T
C
N
L
L
L
I
A
G
H
E
T
T
V
N
L
I
A
N
A
A
-
L
A
M
L
R
T
P
G
Q
W
A
A
L
A
A
D
G
S
R
--
A
S
-
A
V
I
E
E
T
M
R
Y
D
P
P
V
-
Q
-
L
---
V
-
S
--
R
Y
A
G
D
D
L
T
I
-
G
T
H
T
V
P
K
G
D
T
M
L
L
L
L
A
A
A
H
R
D
P
T
I
V
G
A
P
D
R
F
D
P
D
R
-
A
Q
--
I
-
R
H
L
G
F
-
G
K
G
A
H
F
C
L
G
A
P
L
A
R
L
E
A
T
V
A
L
P
A
L
--------------------------------------
22
PsiBlast_CBE
67.29
36%
-122
- C5 -
3R9B
5
?
C:
[28-383]
----------------------------
R
A
D
P
Y
P
I
Y
D
R
I
R
R
G
G
P
---
L
A
LPEANLAV
F
S
S
F
---
S
-
D
--
C
---------
D
D
V
L
R
H
P
S
S
C
S
D
R
T
K
S
T
------------------------
I
F
Q
R
--
Q
-----
L
------------
A
-----------------------------PA---------
S
----------
F
L
------
F
---------
L
D
P
P
D
H
T
R
L
R
G
L
V
S
K
A
F
A
P
R
V
I
K
R
L
E
P
E
I
T
A
-----
L
V
D
Q
L
L
-
D
--
A
-
V
D
-
G
P
E
F
N
L
I
D
N
L
A
Y
P
L
P
V
A
V
I
C
R
L
L
G
V
P
I
-
E
D
E
P
K
F
S
RA
S
A
L
L
A
A
A
-
L
D
P
F
-----
L
A
L
T
G
E
T
S
D
L
F
D
E
Q
M
K
A
G
M
W
---------
L
R
---
D
Y
L
R
A
L
I
D
E
R
R
R
T
P
-
G
E
D
L
M
S
G
L
V
A
-
V
E
E
-
S
G
D
Q
L
T
E
D
E
I
I
A
T
C
N
L
L
L
I
A
G
H
E
T
T
V
N
L
I
A
N
A
A
-
L
A
M
L
R
T
P
G
Q
W
A
A
L
A
A
D
G
S
R
--
A
S
-
A
V
I
E
E
T
M
R
Y
D
P
P
V
-
Q
-
L
---
V
-
S
--
R
Y
A
G
D
D
L
T
I
-
G
T
H
T
V
P
K
G
D
T
M
L
L
L
L
A
A
A
H
R
D
P
T
I
V
G
A
P
D
R
F
D
P
D
R
-
A
Q
--
I
-
R
H
L
G
F
-
G
K
G
A
H
F
C
L
G
A
P
L
A
R
L
E
A
T
V
A
L
P
A
L
--------------------------------------
12
PsiBlast_PDB
67.13
36%
-123
- C5 -
3R9B
9
?
A:
[28-383]
----------------------------
R
A
D
P
Y
P
I
Y
D
R
I
R
R
G
G
P
---
L
A
LPEAN
L
A
V
F
S
S
F
---
S
-
D
--
C
---------
D
D
V
L
R
H
P
S
S
C
S
D
R
T
K
S
T
------------------------
I
F
Q
R
--
Q
-----
L
------------
A
-----------------------------PA---------
S
----------
F
L
------
F
---------
L
D
P
P
D
H
T
R
L
R
G
L
V
S
K
A
F
A
P
R
V
I
K
R
L
E
P
E
I
T
A
-----
L
V
D
Q
L
L
-
D
--
A
-
V
D
-
G
P
E
F
N
L
I
D
N
L
A
Y
P
L
P
V
A
V
I
C
R
L
L
G
V
P
I
-
E
D
E
P
K
F
S
R
A
S
A
L
L
A
A
A
-
L
D
P
F
-----
L
A
L
T
G
E
T
S
D
L
F
D
E
Q
M
K
A
G
M
W
---------
L
R
---
D
Y
L
R
A
L
I
D
E
R
R
R
T
P
-
G
E
D
L
M
S
G
L
V
A
-
V
E
E
-
S
G
D
Q
L
T
E
D
E
I
I
A
T
C
N
L
L
L
I
A
G
H
E
T
T
V
N
L
I
A
N
A
A
-
L
A
M
L
R
T
P
G
Q
W
A
A
L
A
A
D
G
S
R
--
A
S
-
A
V
I
E
E
T
M
R
Y
D
P
P
V
-
Q
-
L
---
V
-
S
--
R
Y
A
G
D
D
L
T
I
-
G
T
H
T
V
P
K
G
D
T
M
L
L
L
L
A
A
A
H
R
D
P
T
I
V
G
A
P
D
R
F
D
P
D
R
-
A
Q
--
I
-
R
H
L
G
F
-
G
K
G
A
H
F
C
L
G
A
P
L
A
R
L
E
A
T
V
A
L
P
A
L
--------------------------------------
4
PsiBlast_PDB
67.04
37%
-129
- C5 -
4E2P
4
?
A:
[35-384]
--------------------------------
F
W
L
Y
G
R
R
P
R
Q
M
----
V
E
--------
F
D
E
K
---
M
-
N
--
A
---------
W
N
V
Y
G
Y
A
E
A
I
E
V
L
G
D
P
G
------------------------
T
F
S
S
--
H
MSRLL-----------------------
F
------
T
E
----------
G
-----------
D
----------
L
L
------
Q
---------
T
D
P
P
D
H
R
E
L
R
K
L
V
S
H
A
F
T
P
K
V
V
A
E
L
E
P
R
I
T
A
-----
L
T
Q
E
L
L
D
A
--
V
-
A
D
-
R
D
T
F
D
L
M
T
A
L
A
Y
P
L
P
V
T
V
V
A
E
L
L
S
I
P
S
-
A
D
R
H
L
F
E
--
G
W
M
T
E
I
V
-
H
S
------------------------
M
A
P
---------
M
R
K
M
L
E
Y
L
R
E
H
A
A
E
C
R
R
R
P
-
R
G
D
L
M
G
K
L
I
E
-
A
E
V
-
D
G
R
R
L
T
D
N
H
I
V
N
F
A
K
M
L
L
I
A
G
Y
L
T
T
T
M
L
I
G
N
T
V
---
L
C
L
D
S
Y
P
E
Q
A
A
R
V
R
A
D
R
SL
I
P
-
G
L
L
E
E
S
M
R
F
L
S
P
V
-
A
-
A
---
T
-
Y
--
R
A
T
T
R
D
V
E
V
-
A
G
Q
R
L
S
A
D
Q
M
V
M
V
W
F
G
A
A
N
R
D
A
R
Q
F
A
E
P
E
L
F
D
M
T
R
-
G
P
--
N
-
P
H
L
G
F
-
G
R
G
I
H
F
C
L
G
G
P
L
A
R
M
E
G
R
V
A
L
D
H
L
L
-------------------------------------
96
PsiBlast_CBE
66.97
37%
-129
- C5 -
2RFB
1
?
B:
[1-314]
--------------------------------------
M
R
L
N
D
P
---
V
H
--------
Y
D
G
---------
A
---------
W
H
V
Y
K
Y
S
D
V
K
H
V
L
M
N
D
K
------------------------
I
F
S
S
--
N
------------------------------------------------GGI--------
S
----------
F
I
------
T
---------
M
D
N
P
E
H
K
E
F
R
D
I
S
A
P
Y
F
L
P
S
K
I
N
D
Y
K
D
F
I
E
E
-----
T
S
N
D
L
I
K
N
--
I
-
D
N
-
K
---
D
I
I
S
E
Y
A
V
R
L
P
V
N
I
I
S
K
I
L
G
I
P
D
-
S
D
M
P
L
F
K
--
L
W
S
D
Y
I
I
-
G
N
K
R
-----
D
E
N
F
N
Y
V
N
N
R
M
V
S
R
---------------
L
L
---
E
I
F
K
--------
S
D
-
S
H
G
I
I
N
V
L
A
G
-
S
S
L
-
K
N
R
K
L
T
M
D
E
K
I
K
Y
I
M
L
L
I
I
G
G
N
E
T
T
T
N
L
I
G
N
M
I
-
R
V
I
D
E
N
P
D
I
I
D
D
A
L
K
N
R
-----
S
-
G
F
V
E
E
T
L
R
Y
Y
S
P
I
-
Q
-
F
---
L
P
H
--
R
F
A
A
E
D
S
Y
I
-
N
N
K
K
I
K
K
G
D
Q
V
I
V
Y
L
G
S
A
N
R
D
E
T
F
F
D
E
P
D
L
F
K
I
G
R
-
R
E
--
M
--
H
L
A
F
-
G
I
G
I
H
M
C
L
G
A
P
L
A
R
L
E
A
S
I
A
L
N
D
I
L
N
------------------------------------