@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu22630: (2016-07-05 )
MFKLDLQPSEKLFIPFITAGDPVPEVSIELAKSLQKAGATALELGVAYSDPLADGPVIQRASKRALDQGMNIVKAIELGGEMKKNGVNIPIILFTYYNPVLQLNKEYFFALLRENHIDGLLVPDLPLEESNSLQEECKSHEVTYISLVAPTSESRLKTIIEQAEGFVYCVSSLGVTGVRNEFNSSVYPFIRTVKNLSTVPVAVGFGISNREQVIKMNEISDGVVVGSALVRKIEELKDRLISAETRNQALQEFEDYAMAFSGLYSLK
Atome Classification :
(67 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150-.-...-....160.......170.......180........190.......200.......210.-..-..-.-.-220.......230---.........240.......250.......260.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MFKLDLQPSE
K
L
F
I
P
F
ITAGDPV
P
E
V
S
I
E
L
A
K
S
L
Q
K
AGA
T
A
L
E
L
GVAYSDPLAD
G
P
V
I
Q
R
A
S
K
R
A
L
D
Q
G
M
N
I
V
K
A
I
ELGGEMKKNGVNI
P
I
I
L
F
TYY
N
P
V
L
QL
N
K
E
Y
F
F
A
L
L
R
ENHID
G
L
LVPDLPLEES
N
S
L
Q
E
E
C
KSH
E
V
T
Y
I
S
L
VAP-T-
S
-
E
S
R
-
L
K
T
I
I
E
QAEGF
V
Y
C
V
S
SLGVTGVRNE-FN
S
S
V
Y
P
F
I
R
T
V
KNLST
V
P
V
A
V
GFGIS
N
R
E
Q
V
-
I
K
-MN-E-I-SD
G
V
V
V
G
S
A
L
V
-----
R
K
I
E
E
L
K
D
R
L
I
S
A
E
T
R
N
Q
A
L
Q
E
F
E
D
Y
A
M
A
F
S
GLYSLK
89
HHSearch
88.12
40%
-85
- C3 -
1RD5
2
TRPA_MAIZE
A:
[15-261]
-------
K
G
K
T
A
F
I
P
Y
I
T
A
G
D
P
D
L
A
T
T
A
E
A
L
R
L
L
D
G
C
G
A
D
V
I
E
L
G
V
P
C
S
D
P
Y
I
D
G
P
I
I
Q
A
S
V
A
R
A
L
A
S
G
T
T
M
D
A
V
L
E
M
L
R
E
V
T
P
-
E
L
S
C
P
V
V
L
L
S
Y
Y
K
P
I
M
F
----
R
S
L
A
K
M
K
E
A
G
V
H
G
L
I
V
P
D
L
P
Y
V
A
A
H
S
L
W
S
E
A
K
N
N
N
L
E
L
V
L
L
T
T
P
-
A
-
I
P
E
D
R
-
M
K
E
I
T
K
A
S
E
G
F
V
Y
L
V
S
V
N
G
V
T
G
P
R
-
A
N
V
N
P
R
V
E
S
L
I
Q
E
V
K
K
V
T
N
K
P
V
A
V
G
F
G
I
S
K
P
E
H
V
-
K
Q
-
I
A
Q
W
-
G
-
A
D
G
V
I
I
G
S
A
M
V
-----
R
Q
L
G
E
A
A
S
P
-------
K
Q
G
L
R
R
L
E
E
Y
A
R
G
M
K
N
A
L
---
4
PsiBlast_PDB
87.67
39%
-83
- C3 -
1TJR
1
TRPA_MAIZE
A:
[19-253]
------------
F
I
P
Y
I
T
A
G
D
P
D
L
A
T
T
A
E
A
L
R
L
L
D
G
C
G
A
D
V
I
E
L
G
V
P
C
S
D
P
Y
I
D
G
P
I
I
Q
A
S
V
A
R
A
L
A
S
G
T
T
M
D
A
V
L
E
M
L
R
E
V
T
P
E
-
L
S
C
P
V
V
L
L
S
Y
Y
K
P
I
M
S
R
S
----
L
A
E
M
K
E
A
G
V
H
G
L
I
V
P
D
L
P
Y
V
A
A
H
S
L
W
S
E
A
K
N
N
N
L
E
L
V
L
L
T
T
P
-
A
I
P
-
E
D
R
-
M
K
E
I
T
K
A
S
E
G
F
V
Y
L
V
S
V
N
G
V
T
G
P
R
A
N
-
V
N
P
R
V
E
S
L
I
Q
E
V
K
K
V
T
N
K
P
V
A
V
G
F
G
I
S
K
P
E
H
V
-
K
Q
-
I
A
-
Q
-
W
G
A
D
G
V
I
I
G
S
A
M
V
-----
R
Q
L
G
E
-------
A
A
S
P
K
Q
G
L
R
R
L
E
E
Y
A
----------
14
PsiBlast_PDB
87.26
39%
-108
- C3 -
2E09
-
TRPA_PYRFU
A:
[7-229]
------------
L
I
P
Y
L
T
A
G
D
P
D
K
Q
S
T
L
N
F
L
L
A
L
D
E
Y
-
A
G
A
I
E
L
G
I
P
F
S
D
P
I
A
D
G
K
T
I
Q
E
S
H
Y
R
A
L
K
N
G
F
K
L
R
E
A
F
W
I
V
K
A
F
R
R
H
S
-
S
T
P
I
V
L
M
T
Y
Y
N
P
I
Y
R
A
G
V
R
N
F
L
A
E
A
K
A
S
G
V
D
G
I
L
V
V
D
L
P
V
F
H
A
K
E
F
T
E
I
A
R
E
E
G
I
K
T
V
F
L
A
A
P
N
T
-
P
-
D
E
R
-
L
K
V
I
D
D
M
T
T
G
F
V
Y
L
V
S
L
Y
G
T
----
E
E
-
I
P
K
T
A
Y
D
L
L
R
R
A
K
R
I
C
R
N
K
V
A
V
G
F
G
V
S
K
R
E
H
V
-
V
S
L
L
K
-
E
-
G
-
A
N
G
V
V
V
G
S
A
L
V
-----
K
I
I
G
E
--------------------------------
2
PsiBlast_PDB
86.52
39%
-84
- C3 -
1RD5
2
TRPA_MAIZE
A:
[20-254]
------------
F
I
P
Y
I
T
A
G
D
P
D
L
A
T
T
A
E
A
L
R
L
L
D
G
C
G
A
D
V
I
E
L
G
V
P
C
S
D
P
Y
I
D
G
P
I
I
Q
A
S
V
A
R
A
L
A
S
G
T
T
M
D
A
V
L
E
M
L
R
E
V
T
P
E
-
L
S
C
P
V
V
L
L
S
Y
Y
K
P
I
M
F
R
S
----
L
A
K
M
K
E
A
G
V
H
G
L
I
V
P
D
L
P
Y
V
A
A
H
S
L
W
S
E
A
K
N
N
N
L
E
L
V
L
L
T
T
P
-
A
I
P
-
E
D
R
-
M
K
E
I
T
K
A
S
E
G
F
V
Y
L
V
S
V
N
G
V
T
G
P
R
A
N
-
V
N
P
R
V
E
S
L
I
Q
E
V
K
K
V
T
N
K
P
V
A
V
G
F
G
I
S
K
P
E
H
V
-
K
Q
-
I
A
-
Q
-
W
G
A
D
G
V
I
I
G
S
A
M
V
-----
R
Q
L
G
E
-------
A
A
S
P
K
Q
G
L
R
R
L
E
E
Y
A
----------
103
Fugue
86.20
37%
-98
- C3 -
1GEQ
-
TRPA_PYRFU
A:
[1-248]
M
F
K
------
D
G
S
L
I
P
Y
L
T
A
G
D
P
D
K
Q
S
T
L
N
F
L
L
A
L
D
E
Y
-
A
G
A
I
E
L
G
I
P
F
S
D
P
I
A
D
G
K
T
I
Q
E
S
H
Y
R
A
L
K
N
G
F
K
L
R
E
A
F
W
I
V
K
E
F
R
R
H
S
-
S
T
P
I
V
L
M
T
Y
Y
N
P
I
Y
R
A
G
V
R
N
F
L
A
E
A
K
A
S
G
V
D
G
I
L
V
V
D
L
P
V
F
H
A
K
E
F
T
E
I
A
R
E
E
G
I
K
T
V
F
L
A
A
P
N
T
-
P
-
D
E
R
-
L
K
V
I
D
D
M
T
T
G
F
V
Y
L
V
S
L
Y
-------
E
-
I
P
K
T
A
Y
D
L
L
R
R
A
K
R
I
C
R
N
K
V
A
V
G
F
G
V
S
K
R
E
H
V
-
V
S
-
L
L
-
K
E
G
-
A
N
G
V
V
V
G
S
A
L
V
-----
K
I
I
G
E
K
---------
G
R
E
A
T
E
F
L
K
K
K
V
E
E
L
L
G
I
----
82
HHSearch
85.48
43%
-127
- C3 -
1UJP
1
TRPA_THET2
A:
[13-251]
-------
E
G
R
A
A
L
I
P
Y
L
T
A
G
F
P
S
R
E
G
F
L
Q
A
V
E
E
V
L
-
P
Y
A
D
L
L
E
I
G
L
P
Y
S
D
----
G
P
V
I
Q
R
A
S
E
L
A
L
R
K
G
M
S
V
Q
G
A
L
E
L
V
R
E
V
R
A
-
L
T
E
K
P
L
F
L
M
T
Y
L
N
P
V
L
A
W
G
P
E
R
F
F
G
L
F
K
Q
A
G
A
T
G
V
I
L
P
D
L
P
P
D
E
D
P
G
L
V
R
L
A
Q
E
I
G
L
E
T
V
F
L
L
A
P
-
T
-
S
T
D
A
R
-
I
A
T
V
V
R
H
A
T
G
F
V
Y
A
V
S
V
-------------
E
V
K
D
L
V
R
R
I
K
A
R
T
A
L
P
V
A
V
G
F
G
V
S
G
K
A
T
A
-
A
Q
-
A
--
A
-
V
-
A
D
G
V
V
V
G
S
A
L
V
-----
R
A
L
E
E
G
-------------------------------
88
HHSearch
85.28
37%
-95
- C3 -
1GEQ
-
TRPA_PYRFU
A:
[3-246]
--------
K
D
G
S
L
I
P
Y
L
T
A
G
D
P
D
K
Q
S
T
L
N
F
L
L
A
L
D
E
-
Y
A
G
A
I
E
L
G
I
P
F
S
D
P
I
A
D
G
K
T
I
Q
E
S
H
Y
R
A
L
K
N
G
F
K
L
R
E
A
F
W
I
V
K
E
F
R
R
-
H
S
S
T
P
I
V
L
M
T
Y
Y
N
P
I
Y
R
A
G
V
R
N
F
L
A
E
A
K
A
S
G
V
D
G
I
L
V
V
D
L
P
V
F
H
A
K
E
F
T
E
I
A
R
E
E
G
I
K
T
V
F
L
A
A
P
-
N
-
T
P
D
E
R
-
L
K
V
I
D
D
M
T
T
G
F
V
Y
L
V
S
L
Y
--------E
I
P
K
T
A
Y
D
L
L
R
R
A
K
R
I
C
R
N
K
V
A
V
G
F
G
V
S
K
R
E
H
V
-
V
S
-
L
L
K
E
-
G
-
A
N
G
V
V
V
G
S
A
L
V
-----
K
I
I
G
E
K
G
R
E
---------
A
T
E
F
L
K
K
K
V
E
E
L
L
------
15
PsiBlast_PDB
84.81
39%
-110
- C3 -
2DZT
-
TRPA_PYRFU
A:
[7-229]
------------
L
I
P
Y
L
T
A
G
D
P
D
K
Q
S
T
L
N
F
L
L
A
L
D
E
Y
-
A
G
A
I
E
L
G
I
P
F
S
D
P
I
A
D
G
K
T
I
Q
E
S
H
Y
R
A
L
K
N
G
F
K
L
R
E
A
F
W
I
V
K
E
F
R
R
H
S
-
S
T
P
I
V
L
M
T
Y
Y
N
P
I
Y
R
A
G
V
R
N
F
L
A
E
A
K
A
S
G
V
A
G
I
L
V
V
D
L
P
V
F
H
A
K
E
F
T
E
I
A
R
E
E
G
I
K
T
V
F
L
A
A
P
N
T
-
P
-
D
E
R
-
L
K
V
I
D
D
M
T
T
G
F
V
Y
L
V
S
L
Y
G
T
----
E
E
-
I
P
K
T
A
Y
D
L
L
R
R
A
K
R
I
C
R
N
K
V
A
V
G
F
G
V
S
K
R
E
H
V
-
V
S
L
L
K
-
E
-
G
-
A
N
G
V
V
V
G
S
A
L
V
-----
K
I
I
G
E
--------------------------------
5
PsiBlast_PDB
84.72
39%
-106
- C3 -
2DZS
-
TRPA_PYRFU
A:
[7-229]
------------
L
I
P
Y
L
T
A
G
D
P
D
K
Q
S
T
L
N
F
L
L
A
L
D
E
Y
-
A
G
A
I
E
L
G
I
P
F
S
D
P
I
A
D
G
K
T
I
Q
E
S
H
Y
R
A
L
K
N
G
F
K
L
R
E
A
F
W
I
V
K
E
F
R
R
H
S
-
S
T
P
I
V
L
M
T
Y
Y
N
P
I
Y
R
A
G
V
R
N
F
L
A
A
A
K
A
S
G
V
D
G
I
L
V
V
D
L
P
V
F
H
A
K
E
F
T
E
I
A
R
E
E
G
I
K
T
V
F
L
A
A
P
N
T
-
P
-
D
E
R
-
L
K
V
I
D
D
M
T
T
G
F
V
Y
L
V
S
L
Y
G
T
----
E
E
-
I
P
K
T
A
Y
D
L
L
R
R
A
K
R
I
C
R
N
K
V
A
V
G
F
G
V
S
K
R
E
H
V
-
V
S
L
L
K
-
E
-
G
-
A
N
G
V
V
V
G
S
A
L
V
-----
K
I
I
G
E
--------------------------------
8
PsiBlast_PDB
84.62
39%
-115
- C3 -
1GEQ
-
TRPA_PYRFU
A:
[7-229]
------------
L
I
P
Y
L
T
A
G
D
P
D
K
Q
S
T
L
N
F
L
L
A
L
D
E
Y
-
A
G
A
I
E
L
G
I
P
F
S
D
P
I
A
D
G
K
T
I
Q
E
S
H
Y
R
A
L
K
N
G
F
K
L
R
E
A
F
W
I
V
K
E
F
R
R
H
S
-
S
T
P
I
V
L
M
T
Y
Y
N
P
I
Y
R
A
G
V
R
N
F
L
A
E
A
K
A
S
G
V
D
G
I
L
V
V
D
L
P
V
F
H
A
K
E
F
T
E
I
A
R
E
E
G
I
K
T
V
F
L
A
A
P
N
T
-
P
-
D
E
R
-
L
K
V
I
D
D
M
T
T
G
F
V
Y
L
V
S
L
Y
-------
E
-
I
P
K
T
A
Y
D
L
L
R
R
A
K
R
I
C
R
N
K
V
A
V
G
F
G
V
S
K
R
E
H
V
-
V
S
L
L
K
-
E
-
G
-
A
N
G
V
V
V
G
S
A
L
V
-----
K
I
I
G
E
--------------------------------
10
PsiBlast_PDB
84.44
39%
-113
- C3 -
5E0K
-
TRPA_PYRFU
A:
[7-229]
------------
L
I
P
Y
L
T
A
G
D
P
D
K
Q
S
T
L
N
F
L
L
A
L
D
E
Y
-
A
G
A
I
E
L
G
I
P
F
S
D
P
I
A
D
G
K
T
I
Q
E
S
H
Y
R
A
L
K
N
G
F
K
L
R
E
A
F
W
I
V
K
E
F
R
R
H
S
-
S
T
P
I
V
L
M
T
Y
Y
N
P
I
Y
R
A
G
V
R
N
F
L
A
E
A
K
A
S
G
V
D
G
I
L
V
V
D
L
P
V
F
H
A
K
E
F
T
E
I
A
R
E
E
G
I
K
T
V
F
L
A
A
P
N
T
-
P
-
D
E
R
-
L
K
V
I
D
D
M
T
T
G
F
V
Y
L
V
S
L
Y
------
E
E
-
I
P
K
T
A
Y
D
L
L
R
R
A
K
R
I
C
R
N
K
V
A
V
G
F
G
V
S
K
R
E
H
V
-
V
S
L
L
K
-
E
-
G
-
A
N
G
V
V
V
G
S
A
L
V
-----
K
I
I
G
E
--------------------------------
7
PsiBlast_PDB
84.07
39%
-106
- C3 -
2DZW
-
TRPA_PYRFU
A:
[7-229]
------------
L
I
P
Y
L
T
A
G
D
P
D
K
Q
S
T
L
N
F
L
L
A
L
D
E
Y
-
A
G
A
I
E
L
G
I
P
F
S
D
P
I
A
D
G
K
T
I
Q
E
S
H
Y
R
A
L
K
N
G
F
K
L
R
E
A
F
W
I
V
K
E
F
R
R
H
S
-
S
T
P
I
V
L
M
T
Y
Y
N
P
I
Y
R
A
G
V
R
N
F
L
A
E
A
K
A
S
G
V
D
G
I
L
V
V
D
L
P
V
F
H
A
K
E
F
T
E
I
A
R
E
E
G
I
K
T
V
F
L
A
A
P
N
T
-
P
-
D
E
R
-
L
K
V
I
D
D
M
T
T
G
F
V
Y
L
V
S
L
Y
G
T
----
E
E
-
I
P
K
T
A
Y
D
L
L
R
R
A
K
R
I
C
R
N
K
V
A
V
G
F
G
V
S
K
R
E
H
V
-
V
S
L
L
K
-
E
-
G
-
A
N
G
V
V
V
G
S
A
L
V
-----
K
I
I
G
E
--------------------------------
11
PsiBlast_PDB
83.63
39%
-106
- C3 -
2DZP
-
TRPA_PYRFU
A:
[7-229]
------------
L
I
P
Y
L
T
A
G
D
P
N
K
Q
S
T
L
N
F
L
L
A
L
D
E
Y
-
A
G
A
I
E
L
G
I
P
F
S
D
P
I
A
D
G
K
T
I
Q
E
S
H
Y
R
A
L
K
N
G
F
K
L
R
E
A
F
W
I
V
K
E
F
R
R
H
S
-
S
T
P
I
V
L
M
T
Y
Y
N
P
I
Y
R
A
G
V
R
N
F
L
A
E
A
K
A
S
G
V
D
G
I
L
V
V
D
L
P
V
F
H
A
K
E
F
T
E
I
A
R
E
E
G
I
K
T
V
F
L
A
A
P
N
T
-
P
-
D
E
R
-
L
K
V
I
D
D
M
T
T
G
F
V
Y
L
V
S
L
Y
G
T
----
E
E
-
I
P
K
T
A
Y
D
L
L
R
R
A
K
R
I
C
R
N
K
V
A
V
G
F
G
V
S
K
R
E
H
V
-
V
S
L
L
K
-
E
-
G
-
A
N
G
V
V
V
G
S
A
L
V
-----
K
I
I
G
E
--------------------------------
12
PsiBlast_PDB
83.58
39%
-106
- C3 -
2DZV
-
TRPA_PYRFU
A:
[7-229]
------------
L
I
P
Y
L
T
A
G
D
P
D
K
Q
S
T
L
N
F
L
L
A
L
D
E
Y
-
A
G
A
I
E
L
G
I
P
F
S
D
P
I
A
D
G
K
T
I
Q
E
S
H
Y
R
A
L
K
N
G
F
K
L
R
E
A
F
W
I
V
K
E
F
R
R
H
S
-
S
T
P
I
V
L
M
T
Y
Y
N
P
I
Y
R
A
G
V
R
N
F
L
A
E
A
K
A
S
G
V
D
G
I
L
V
V
D
L
P
V
F
H
A
K
E
F
T
E
I
A
R
E
E
G
I
K
T
V
F
L
A
A
P
N
T
-
P
-
A
E
R
-
L
K
V
I
D
D
M
T
T
G
F
V
Y
L
V
S
L
Y
G
T
----
E
E
-
I
P
K
T
A
Y
D
L
L
R
R
A
K
R
I
C
R
N
K
V
A
V
G
F
G
V
S
K
R
E
H
V
-
V
S
L
L
K
-
E
-
G
-
A
N
G
V
V
V
G
S
A
L
V
-----
K
I
I
G
E
--------------------------------
13
PsiBlast_PDB
83.41
39%
-107
- C3 -
2DZU
-
TRPA_PYRFU
A:
[7-229]
------------
L
I
P
Y
L
T
A
G
D
P
D
K
Q
S
T
L
N
F
L
L
A
L
D
E
Y
-
A
G
A
I
E
L
G
I
P
F
S
D
P
I
A
D
G
K
T
I
Q
E
S
H
Y
R
A
L
K
N
G
F
K
L
R
E
A
F
W
I
V
K
E
F
R
R
H
S
-
S
T
P
I
V
L
M
T
Y
Y
N
P
I
Y
R
A
G
V
R
N
F
L
A
E
A
K
A
S
G
V
N
G
I
L
V
V
D
L
P
V
F
H
A
K
E
F
T
E
I
A
R
E
E
G
I
K
T
V
F
L
A
A
P
N
T
-
P
-
D
E
R
-
L
K
V
I
D
D
M
T
T
G
F
V
Y
L
V
S
L
Y
G
T
----
E
E
-
I
P
K
T
A
Y
D
L
L
R
R
A
K
R
I
C
R
N
K
V
A
V
G
F
G
V
S
K
R
E
H
V
-
V
S
L
L
K
-
E
-
G
-
A
N
G
V
V
V
G
S
A
L
V
-----
K
I
I
G
E
--------------------------------
6
PsiBlast_PDB
83.18
39%
-111
- C3 -
2DZX
-
TRPA_PYRFU
A:
[7-229]
------------
L
I
P
Y
L
T
A
G
D
P
D
K
Q
S
T
L
N
F
L
L
A
L
D
E
Y
-
A
G
A
I
E
L
G
I
P
F
S
D
P
I
A
D
G
K
T
I
Q
E
S
H
Y
R
A
L
K
N
G
F
K
L
R
E
A
F
W
I
V
K
E
F
R
R
H
S
-
S
T
P
I
V
L
M
T
Y
Y
N
P
I
Y
R
A
G
V
R
N
F
L
A
E
A
K
A
S
G
V
D
G
I
L
V
V
D
L
P
V
F
H
A
K
E
F
T
E
I
A
R
A
A
G
I
K
T
V
F
L
A
A
P
N
T
-
P
-
D
E
R
-
L
K
V
I
D
D
M
T
T
G
F
V
Y
L
V
S
L
Y
G
T
----
E
E
-
I
P
K
T
A
Y
D
L
L
R
R
A
K
R
I
C
R
N
K
V
A
V
G
F
G
V
S
K
R
E
H
V
-
V
S
L
L
K
-
E
-
G
-
A
N
G
V
V
V
G
S
A
L
V
-----
K
I
I
G
E
--------------------------------
16
PsiBlast_PDB
82.87
33%
-164
- C- -
3THA
-
TRPA_CAMJE
A:
[14-229]
-------------
V
A
Y
T
V
L
G
Y
P
N
L
Q
T
S
E
A
F
L
Q
R
L
D
Q
S
P
I
D
I
L
E
L
G
V
A
Y
S
D
P
I
A
D
G
E
I
I
A
D
A
A
K
I
A
L
D
Q
G
V
D
I
H
S
V
F
E
L
L
A
R
I
K
T
K
K
---
A
L
V
F
M
V
Y
Y
N
L
I
F
S
Y
G
L
E
K
F
V
K
K
A
K
S
L
G
I
C
A
L
I
V
P
E
L
S
F
E
E
S
D
D
L
I
K
E
C
E
R
Y
N
I
A
L
I
T
L
V
S
V
-
T
-
T
P
K
E
R
-
V
K
K
L
V
K
H
A
K
G
F
I
Y
L
L
A
S
I
G
I
T
G
T
K
S
V
-
E
E
A
I
L
Q
D
K
V
K
E
I
R
S
F
T
N
L
P
I
F
V
G
F
G
I
Q
N
N
Q
D
V
-
K
R
-
M
R
-
K
-
V
-
A
D
G
V
I
V
G
T
S
I
V
-----
K
------------------------------------
9
PsiBlast_PDB
82.46
39%
-106
- C3 -
1WDW
-
TRPA_PYRFU
A:
[7-229]
------------
L
I
P
Y
L
T
A
G
D
P
D
K
Q
S
T
L
N
F
L
L
A
L
D
E
Y
-
A
G
A
I
E
L
G
I
P
F
S
D
P
I
A
D
G
K
T
I
Q
E
S
H
Y
R
A
L
K
N
G
F
K
L
R
E
A
F
W
I
V
K
E
F
R
R
H
S
-
S
T
P
I
V
L
M
T
Y
Y
N
P
I
Y
R
A
G
V
R
N
F
L
A
E
A
K
A
S
G
V
D
G
I
L
V
V
D
L
P
V
F
H
A
K
E
F
T
E
I
A
R
E
E
G
I
K
T
V
F
L
A
A
P
N
T
-
P
-
D
E
R
-
L
K
V
I
D
D
M
T
T
G
F
V
Y
L
V
S
L
Y
------
E
E
-
I
P
K
T
A
Y
D
L
L
R
R
A
K
R
I
C
R
N
K
V
A
V
G
F
G
V
S
K
R
E
H
V
-
V
S
L
L
K
-
E
-
G
-
A
N
G
V
V
V
G
S
A
L
V
-----
K
I
I
G
E
--------------------------------
1
PsiBlast_PDB
81.40
40%
-112
- C3 -
1WXJ
5
TRPA_THET2
A:
[18-257]
------------
L
I
P
Y
L
T
A
G
F
P
S
R
E
G
F
L
Q
A
V
E
E
V
L
P
Y
-
A
D
L
L
E
I
G
L
P
Y
S
-----
G
P
V
I
Q
R
A
S
E
L
A
L
R
K
G
M
S
V
Q
G
A
L
E
L
V
R
E
V
R
A
L
-
T
E
K
P
L
F
L
M
T
Y
L
N
P
V
L
A
W
G
P
E
R
F
F
G
L
F
K
Q
A
G
A
T
G
V
I
L
P
D
L
P
P
D
E
D
P
G
L
V
R
L
A
Q
E
I
G
L
E
T
V
F
L
L
A
P
-
T
-
S
T
D
A
R
-
I
A
T
V
V
R
H
A
T
G
F
V
Y
A
V
S
--------------
E
V
K
D
L
V
R
R
I
K
A
R
T
A
L
P
V
A
V
G
F
G
V
S
G
K
-
A
T
-
A
A
-
Q
A
-
A
-
V
-
A
D
G
V
V
V
G
S
A
L
V
-----
R
A
L
E
E
G
R
S
L
A
P
L
L
Q
E
I
R
Q
G
L
Q
R
L
E
-------------
3
PsiBlast_PDB
81.19
39%
-112
- C3 -
2EKC
-
TRPA_AQUAE
A:
[13-249]
------
E
K
R
E
K
A
L
V
S
Y
L
M
V
G
Y
P
D
Y
E
T
S
L
K
A
F
K
E
V
L
K
N
G
T
D
I
L
E
I
G
F
P
F
S
D
P
V
A
D
G
P
T
I
Q
V
A
H
E
V
A
L
K
N
G
I
R
F
E
D
V
L
E
L
S
E
T
L
R
K
E
F
P
D
I
P
F
L
L
M
T
Y
Y
N
P
I
F
R
I
G
L
E
K
F
C
R
L
S
R
E
K
G
I
D
G
F
I
V
P
D
L
P
P
E
E
A
E
E
L
K
A
V
M
K
K
Y
V
L
S
F
V
P
L
G
A
P
-
T
-
S
T
R
K
R
-
I
K
L
I
C
E
A
A
D
E
M
T
Y
F
V
S
V
T
G
---------
Y
E
R
I
K
K
K
V
E
E
Y
R
E
L
C
D
K
P
V
V
V
G
F
G
V
S
K
K
E
H
A
-
R
E
-
I
G
-
S
-
F
-
A
D
G
V
V
V
G
S
A
L
V
K
L
A
G
Q
K
K
I
E
D
L
-------------------------------
27
PsiBlast_CBE
79.06
35%
-105
- C3 -
4KKX
6
TRPA_SALTY
A:
[16-243]
---------
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
-
N
-
A
-
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
A
E
N
R
-
G
A
L
P
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
-
V
R
-
A
-
G
-
A
A
G
A
I
S
G
S
A
I
V
-----
K
I
I
E
K
--------------------------------
61
PsiBlast_CBE
78.98
35%
-102
- C3 -
1WBJ
1
TRPA_SALTY
A:
[16-243]
---------
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
I
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
-
N
-
A
-
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
A
E
N
R
-
G
A
L
P
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
-
V
R
-
A
-
G
-
A
A
G
A
I
S
G
S
A
I
V
-----
K
I
I
E
K
--------------------------------
60
PsiBlast_CBE
78.98
35%
-102
- C3 -
2CLK
1
TRPA_SALTY
A:
[16-243]
---------
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
I
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
-
N
-
A
-
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
A
E
N
R
-
G
A
L
P
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
-
V
R
-
A
-
G
-
A
A
G
A
I
S
G
S
A
I
V
-----
K
I
I
E
K
--------------------------------
31
PsiBlast_CBE
78.86
35%
-103
- C3 -
4HN4
1
TRPA_SALTY
A:
[16-243]
---------
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
-
N
-
A
-
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
A
E
N
R
-
G
A
L
P
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
-
V
R
-
A
-
G
-
A
A
G
A
I
S
G
S
A
I
V
-----
K
I
I
E
K
--------------------------------
62
PsiBlast_CBE
78.84
35%
-102
- C3 -
1QOP
1
TRPA_SALTY
A:
[16-243]
---------
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
I
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
-
N
-
A
-
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
A
E
N
R
-
G
--
P
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
-
V
R
-
A
-
G
-
A
A
G
A
I
S
G
S
A
I
V
-----
K
I
I
E
K
--------------------------------
55
PsiBlast_CBE
78.33
35%
-101
- C3 -
1C8V
1
TRPA_SALTY
A:
[16-243]
---------
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
-
N
-
A
-
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
A
E
N
R
-
G
--
P
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
-
V
R
-
A
-
G
-
A
A
G
A
I
S
G
S
A
I
V
-----
K
I
I
E
K
--------------------------------
56
PsiBlast_CBE
78.22
35%
-101
- C3 -
1C29
1
TRPA_SALTY
A:
[16-243]
---------
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
-
N
-
A
-
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
A
E
N
R
-
G
--
P
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
-
V
R
-
A
-
G
-
A
A
G
A
I
S
G
S
A
I
V
-----
K
I
I
E
K
--------------------------------
30
PsiBlast_CBE
78.17
35%
-105
- C3 -
4HPJ
3
TRPA_SALTY
A:
[16-243]
---------
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
-
N
-
A
-
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
A
E
N
R
-
G
A
L
P
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
-
V
R
-
A
-
G
-
A
A
G
A
I
S
G
S
A
I
V
-----
K
I
I
E
K
--------------------------------
28
PsiBlast_CBE
78.10
35%
-106
- C3 -
4HT3
8
TRPA_SALTY
A:
[16-243]
---------
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
-
N
-
A
-
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
A
E
N
R
-
G
A
L
P
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
-
V
R
-
A
-
G
-
A
A
G
A
I
S
G
S
A
I
V
-----
K
I
I
E
K
--------------------------------
25
PsiBlast_CBE
78.04
35%
-105
- C3 -
4XUG
1
TRPA_SALTY
A:
[16-243]
---------
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
-
N
-
A
-
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
A
E
N
R
-
G
A
L
P
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
-
V
R
-
A
-
G
-
A
A
G
A
I
S
G
S
A
I
V
-----
K
I
I
E
K
--------------------------------
53
PsiBlast_CBE
78.01
35%
-103
- C3 -
1CW2
1
TRPA_SALTY
A:
[16-243]
---------
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
-
N
-
A
-
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
A
E
N
R
-
G
--
P
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
-
V
R
-
A
-
G
-
A
A
G
A
I
S
G
S
A
I
V
-----
K
I
I
E
K
--------------------------------
29
PsiBlast_CBE
77.93
35%
-103
- C3 -
4HPX
4
TRPA_SALTY
A:
[16-243]
---------
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
-
N
-
A
-
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
A
E
N
R
-
G
A
L
P
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
-
V
R
-
A
-
G
-
A
A
G
A
I
S
G
S
A
I
V
-----
K
I
I
E
K
--------------------------------
44
PsiBlast_CBE
77.89
35%
-103
- C3 -
1TJP
1
TRPA_SALTY
A:
[16-243]
---------
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
-
N
-
A
-
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
A
E
N
R
-
G
A
L
P
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
-
V
R
-
A
-
G
-
A
A
G
A
I
S
G
S
A
I
V
-----
K
I
I
E
K
--------------------------------
32
PsiBlast_CBE
77.87
35%
-112
- C3 -
2TSY
1
TRPA_SALTY
A:
[16-243]
---------
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
-
N
-
A
-
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
A
E
N
-------
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
-
V
R
-
A
-
G
-
A
A
G
A
I
S
G
S
A
I
V
-----
K
I
I
E
K
--------------------------------
50
PsiBlast_CBE
77.85
35%
-102
- C3 -
1K3U
1
TRPA_SALTY
A:
[16-243]
---------
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
-
N
-
A
-
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
A
E
N
R
-
G
A
L
P
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
-
V
R
-
A
-
G
-
A
A
G
A
I
S
G
S
A
I
V
-----
K
I
I
E
K
--------------------------------
58
PsiBlast_CBE
77.80
35%
-107
- C3 -
1A50
1
TRPA_SALTY
A:
[16-243]
---------
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
-
N
-
A
-
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
A
E
N
-------
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
-
V
R
-
A
-
G
-
A
A
G
A
I
S
G
S
A
I
V
-----
K
I
I
E
K
--------------------------------
59
PsiBlast_CBE
77.76
35%
-103
- C3 -
3CEP
1
TRPA_SALTY
A:
[16-243]
---------
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
I
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
-
N
-
A
-
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
A
E
N
R
-
G
A
L
P
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
-
V
R
-
A
-
G
-
A
A
G
A
I
S
G
S
A
I
V
-----
K
I
I
E
K
--------------------------------
57
PsiBlast_CBE
77.75
35%
-107
- C3 -
1A5S
1
TRPA_SALTY
A:
[16-243]
---------
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
-
N
-
A
-
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
A
E
N
---------
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
-
V
R
-
A
-
G
-
A
A
G
A
I
S
G
S
A
I
V
-----
K
I
I
E
K
--------------------------------
49
PsiBlast_CBE
77.73
35%
-113
- C3 -
1K7E
1
TRPA_SALTY
A:
[16-243]
---------
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
-
N
-
A
-
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
--------
P
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
-
V
R
-
A
-
G
-
A
A
G
A
I
S
G
S
A
I
V
-----
K
I
I
E
K
--------------------------------
36
PsiBlast_CBE
77.66
35%
-103
- C3 -
2J9X
2
TRPA_SALTY
A:
[16-243]
---------
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
-
N
-
A
-
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
A
E
N
R
-
G
---
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
-
V
R
-
A
-
G
-
A
A
G
A
I
S
G
S
A
I
V
-----
K
I
I
E
K
--------------------------------
51
PsiBlast_CBE
77.62
35%
-106
- C3 -
1FUY
1
TRPA_SALTY
A:
[16-243]
---------
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
-
N
-
A
-
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
A
E
N
------
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
-
V
R
-
A
-
G
-
A
A
G
A
I
S
G
S
A
I
V
-----
K
I
I
E
K
--------------------------------
54
PsiBlast_CBE
77.44
35%
-100
- C3 -
1C9D
1
TRPA_SALTY
A:
[16-243]
---------
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
-
N
-
A
-
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
A
E
N
R
-
G
--
P
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
-
V
R
-
A
-
G
-
A
A
G
A
I
S
G
S
A
I
V
-----
K
I
I
E
K
--------------------------------
40
PsiBlast_CBE
77.44
35%
-108
- C3 -
2CLI
1
TRPA_SALTY
A:
[16-243]
---------
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
-
N
-
A
-
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
-----------
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
-
V
R
-
A
-
G
-
A
A
G
A
I
S
G
S
A
I
V
-----
K
I
I
E
K
--------------------------------
23
PsiBlast_CBE
77.03
35%
-106
- C3 -
4ZQC
5
?
A:
[16-243]
---------
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
-
N
-
A
-
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
A
E
N
R
-
G
A
L
P
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
-
V
R
-
A
-
G
-
A
A
G
A
I
S
G
S
A
I
V
-----
K
I
I
E
K
--------------------------------
17
PsiBlast_PDB
76.85
35%
-102
- C3 -
3PR2
1
TRPA_SALTY
A:
[15-242]
---------
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
-
N
-
A
-
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
A
E
N
R
-
G
A
L
P
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
-
V
R
-
A
-
G
-
A
A
G
A
I
S
G
S
A
I
V
-----
K
I
I
E
K
--------------------------------
73
PsiBlast_CBE
76.24
35%
-113
* C3 *
1KFB
1
TRPA_SALTY
A:
[16-243]
---------
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
-
N
-
A
-
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
--------------
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
-
V
R
-
A
-
G
-
A
A
G
A
I
S
G
S
A
I
V
-----
K
I
I
E
K
--------------------------------
52
PsiBlast_CBE
76.06
35%
-100
- C3 -
1CX9
1
TRPA_SALTY
A:
[16-243]
---------
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
-
N
-
A
-
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
A
E
N
R
-
G
--
P
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
-
V
R
-
A
-
G
-
A
A
G
A
I
S
G
S
A
I
V
-----
K
I
I
E
K
--------------------------------
45
PsiBlast_CBE
76.05
35%
-119
- C3 -
1QOQ
1
TRPA_SALTY
A:
[16-243]
---------
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
-
N
-
A
-
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
---------------
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
-
V
R
-
A
-
G
-
A
A
G
A
I
S
G
S
A
I
V
-----
K
I
I
E
K
--------------------------------
42
PsiBlast_CBE
75.99
35%
-120
- C3 -
2CLF
1
TRPA_SALTY
A:
[16-243]
---------
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
-
N
-
A
-
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
----------------
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
-
V
R
-
A
-
G
-
A
A
G
A
I
S
G
S
A
I
V
-----
K
I
I
E
K
--------------------------------
46
PsiBlast_CBE
75.84
35%
-116
- C3 -
1K8Z
1
TRPA_SALTY
A:
[16-243]
---------
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
-
N
-
A
-
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
------------
A
L
P
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
-
V
R
-
A
-
G
-
A
A
G
A
I
S
G
S
A
I
V
-----
K
I
I
E
K
--------------------------------
39
PsiBlast_CBE
75.77
35%
-111
- C3 -
2CLL
1
TRPA_SALTY
A:
[16-243]
---------
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
-
N
-
A
-
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
----------
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
-
V
R
-
A
-
G
-
A
A
G
A
I
S
G
S
A
I
V
-----
K
I
I
E
K
--------------------------------
34
PsiBlast_CBE
75.57
35%
-120
- C3 -
2RHG
1
TRPA_SALTY
A:
[16-243]
---------
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
-
N
-
A
-
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
------------------
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
-
V
R
-
A
-
G
-
A
A
G
A
I
S
G
S
A
I
V
-----
K
I
I
E
K
--------------------------------
41
PsiBlast_CBE
75.56
35%
-111
- C3 -
2CLH
1
TRPA_SALTY
A:
[16-243]
---------
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
-
N
-
A
-
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
----------
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
-
V
R
-
A
-
G
-
A
A
G
A
I
S
G
S
A
I
V
-----
K
I
I
E
K
--------------------------------
35
PsiBlast_CBE
75.45
35%
-120
- C3 -
2RH9
1
TRPA_SALTY
A:
[16-243]
---------
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
-
N
-
A
-
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
---------------
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
-
V
R
-
A
-
G
-
A
A
G
A
I
S
G
S
A
I
V
-----
K
I
I
E
K
--------------------------------
37
PsiBlast_CBE
75.44
35%
-109
- C3 -
2CLO
1
TRPA_SALTY
A:
[16-243]
---------
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
-
N
-
A
-
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
----------
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
-
V
R
-
A
-
G
-
A
A
G
A
I
S
G
S
A
I
V
-----
K
I
I
E
K
--------------------------------
26
PsiBlast_CBE
75.34
35%
-120
- C3 -
4WX2
2
TRPA_SALTY
A:
[16-243]
---------
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
-
N
-
A
-
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
----------------
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
-
V
R
-
A
-
G
-
A
A
G
A
I
S
G
S
A
I
V
-----
K
I
I
E
K
--------------------------------
38
PsiBlast_CBE
75.32
35%
-118
- C3 -
2CLM
1
TRPA_SALTY
A:
[16-243]
---------
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
-
N
-
A
-
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
----------------
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
-
V
R
-
A
-
G
-
A
A
G
A
I
S
G
S
A
I
V
-----
K
I
I
E
K
--------------------------------
47
PsiBlast_CBE
75.18
35%
-118
- C3 -
1K8Y
1
TRPA_SALTY
A:
[16-243]
---------
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
-
N
-
A
-
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
--------------
P
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
-
V
R
-
A
-
G
-
A
A
G
A
I
S
G
S
A
I
V
-----
K
I
I
E
K
--------------------------------
33
PsiBlast_CBE
75.18
35%
-106
- C3 -
2TRS
1
TRPA_SALTY
A:
[16-243]
---------
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
-
N
-
A
-
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
A
E
N
-------
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
-
V
R
-
A
-
G
-
A
A
G
A
I
S
G
S
A
I
V
-----
K
I
I
E
K
--------------------------------
43
PsiBlast_CBE
75.09
35%
-116
- C3 -
2CLE
1
TRPA_SALTY
A:
[16-243]
---------
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
-
N
-
A
-
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
----------------
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
-
V
R
-
A
-
G
-
A
A
G
A
I
S
G
S
A
I
V
-----
K
I
I
E
K
--------------------------------
74
PsiBlast_CBE
75.06
35%
-116
- C3 -
1KFC
1
TRPA_SALTY
A:
[16-243]
---------
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
I
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
-
N
-
A
-
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
---------------
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
-
V
R
-
A
-
G
-
A
A
G
A
I
S
G
S
A
I
V
-----
K
I
I
E
K
--------------------------------
71
PsiBlast_CBE
75.00
35%
-112
- C3 -
1BEU
1
TRPA_SALTY
A:
[16-243]
---------
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
N
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
-
N
-
A
-
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
----------------
L
P
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
-
V
R
-
A
-
G
-
A
A
G
A
I
S
G
S
A
I
V
-----
K
I
I
E
K
--------------------------------
24
PsiBlast_CBE
75.00
35%
-117
- C3 -
4Y6G
1
?
A:
[16-243]
---------
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
-
N
-
A
-
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
------------
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
-
V
R
-
A
-
G
-
A
A
G
A
I
S
G
S
A
I
V
-----
K
I
I
E
K
--------------------------------
48
PsiBlast_CBE
74.82
35%
-117
- C3 -
1K7F
1
TRPA_SALTY
A:
[16-243]
---------
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
-
N
-
A
-
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
---------------
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
-
V
R
-
A
-
G
-
A
A
G
A
I
S
G
S
A
I
V
-----
K
I
I
E
K
--------------------------------
75
PsiBlast_CBE
74.38
35%
-119
- C3 -
1WQ5
10
TRPA_ECOLI
B:
[16-243]
---------
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
E
A
G
A
D
A
L
E
L
G
I
P
F
S
D
P
L
-----
I
Q
N
A
T
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
Q
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
K
G
I
D
E
F
Y
A
Q
C
E
K
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
V
A
P
I
F
I
C
P
P
-
N
-
A
-
D
D
D
L
L
R
Q
I
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
A
G
V
T
--
E
N
R
-
A
A
L
P
L
N
H
L
V
A
K
L
K
E
Y
N
A
A
P
P
L
Q
G
F
G
I
S
A
P
D
Q
V
K
A
A
-
I
D
-
A
-
G
-
A
A
G
A
I
S
G
S
A
I
V
-----
K
I
I
E
Q
--------------------------------
22
PsiBlast_CBE
74.32
35%
-115
- C3 -
5BW6
1
?
A:
[16-243]
---------
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
-
N
-
A
-
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
--------------
L
H
H
L
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
-
V
R
-
A
-
G
-
A
A
G
A
I
S
G
S
A
I
V
-----
K
I
I
E
K
--------------------------------
72
PsiBlast_CBE
73.44
35%
-124
- C3 -
1A5B
1
TRPA_SALTY
A:
[16-243]
---------
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
L
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
N
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
-
N
-
A
-
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
--------------------
I
E
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
-
V
R
-
A
-
G
-
A
A
G
A
I
S
G
S
A
I
V
-----
K
I
I
E
K
--------------------------------