@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu29970: (2016-07-18 )
MLKIVANTADLIGDTPLVRLNRLQPENAAQVYLKLEFFNPSGSVKDRAAYQMIIEAEQNGLLKPGSVIIEPTSGNTGIGLAMNAAARGYKAILVMPDTMTKERINLLKAYGAEVVLTPGEERMPGSIKKAKELAEQIPNSYIPMQFDNTANPDAHRKTTAPEIARAIEEIGKPLGAFVASSGTGGTITGTGEALKELFPDITVHVVEPAGSPVLSGGKPGAHKLVGTSPGFIPPILNEDVYDEIIKISDEDAYTTTRRLAAEEGILVGPSSGAACFAAIETAKRLSPDKVVVCMTADTGERYLSTDLWSFI
Atome Classification :
(68 SA)
.........10........20..-.---...-------.--.30..--......40........50........60...--.-.--...70........80........90........100.......110.......120.---...---...130.....-.-.140..-.....150...-....160.......170........180.......190...--..--.-.200......-.210-.-----.-.---..------.----.220...-....230.......240.......250.......260.......270.-......280..---.-.-..-.290.......300..---.---....310
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
L
K
I
VAN
T
A
D
LIGDTP
L
V
R
L
NRL-Q---PEN-------
A
--
A
Q
V
Y
L
--
K
L
E
F
FNPSGSV
K
D
R
A
A
Y
Q
M
I
I
EAEQNGLLKP--G-
S
--
V
I
I
E
PTSGNTG
I
G
L
A
M
N
AAARG
Y
K
A
I
L
V
MPDT
M
T
K
E
R
I
N
L
L
K
A
YG
A
E
V
V
LTPGEERM---PG
S
---
I
K
K
A
K
E
L
A
E
QI-P-NSYIPM-QFDNTANPDAH-RKT
T
A
P
E
I
A
R
A
I
E
E
IG-
K
P
L
G
A
F
VASSGTGG
T
I
TG
T
G
E
A
L
K
--
E
L--F-PD
I
T
V
H
V
VEP-AGSP-V-----L-S---GG------K----PGAHKLV-GTSPGFIPPILN
E
D
V
Y
D
E
I
I
KISDEDA
Y
T
T
T
R
R
LAAEE
G
I
L
VGPSSG
A
-
A
C
F
A
A
I
E
T
A
KR---L-S-P
D
-
K
V
V
V
C
M
TADTGE
R
Y
L
S
---
T
---
D
L
W
SFI-
16
PsiBlast_PDB
91.00
53%
-90
- C- -
3RR2
-
?
A:
[1-299]
-
M
T
I
A
E
N
I
T
Q
L
I
G
G
T
P
L
V
R
L
R
R
V
-
T
---
D
G
A
-------
A
--
A
D
V
V
A
--
K
L
E
S
F
N
P
A
G
S
I
K
D
R
I
G
V
A
M
I
D
A
A
E
K
A
G
L
I
K
P
--
D
-
T
--
I
I
L
E
P
T
S
G
N
T
G
I
A
L
A
M
V
S
A
A
R
G
Y
K
C
V
L
T
M
P
D
T
M
S
I
E
R
R
M
L
L
R
A
Y
G
A
E
L
V
L
T
P
----
M
---
A
G
A
---
I
A
K
A
E
E
L
A
K
T
D
-
D
-
R
Y
F
I
P
Q
-
Q
F
E
N
P
A
N
P
A
V
H
-
A
V
T
T
A
E
E
V
W
R
D
T
D
--
G
-
K
-
V
D
I
F
V
S
G
V
G
T
G
G
T
I
T
G
V
A
Q
V
I
K
--
Q
R
--
R
-
P
S
A
Q
F
V
A
V
E
P
-
A
A
S
P
-
V
------------------------
K
G
P
H
P
I
Q
-
G
I
G
A
G
F
V
P
P
V
L
D
L
A
L
V
D
E
V
I
T
V
G
N
D
D
A
L
E
L
A
R
R
M
A
T
E
E
G
L
L
V
G
I
S
S
G
A
-
A
V
W
A
A
R
E
L
A
H
R
P--
E
-
N
-
A
G
-
K
L
I
V
V
V
L
P
D
F
G
E
R
Y
----------------
14
PsiBlast_PDB
88.13
52%
-78
- C3 -
2Q3B
5
CYSK_MYCTU
A:
[4-303]
-
M
S
I
A
E
D
I
T
Q
L
I
G
R
T
P
L
V
R
L
R
R
V
-
T
---
D
G
A
-------
V
--
A
D
I
V
A
--
K
L
E
F
F
N
P
A
N
S
V
K
D
R
I
G
V
A
M
L
Q
A
A
E
Q
A
G
L
I
K
P
--
D
-
T
--
I
I
L
E
P
T
S
G
N
T
G
I
A
L
A
M
V
C
A
A
R
G
Y
R
C
V
L
T
M
P
E
T
M
S
L
E
R
R
M
L
L
R
A
Y
G
A
E
L
I
L
T
P
G
A
D
G
M
---
S
G
A
---
I
A
K
A
E
E
L
A
K
T
D
-
Q
-
R
Y
F
V
P
Q
-
Q
F
E
N
P
A
N
P
A
I
H
-
R
V
T
T
A
E
E
V
W
R
D
T
D
--
G
-
K
-
V
D
I
V
V
A
G
V
G
T
G
G
T
I
T
G
V
A
Q
V
I
K
--
E
R
--
K
-
P
S
A
R
F
V
A
V
E
P
-
A
A
S
P
-
V
-----
L
-
S
---
G
G
------
Q
----
K
G
P
H
P
I
Q
-
G
I
G
A
G
F
V
P
P
V
L
D
Q
D
L
V
D
E
I
I
T
V
G
N
E
D
A
L
N
V
A
R
R
L
A
R
E
E
G
L
L
V
G
I
S
S
G
A
-
A
T
V
A
A
L
Q
V
A
R
R
P--
E
-
N
-
A
G
-
K
L
I
V
V
V
L
P
D
F
G
E
R
Y
L
---------------
12
PsiBlast_PDB
87.84
52%
-82
- C3 -
3ZEI
4
CYSK_MYCTU
A:
[1-300]
-
M
S
I
A
E
D
I
T
Q
L
I
G
R
T
P
L
V
R
L
R
R
V
-
T
---
D
G
A
-------
V
--
A
D
I
V
A
--
K
L
E
F
F
N
P
A
N
S
V
K
D
R
I
G
V
A
M
L
Q
A
A
E
Q
A
G
L
I
K
P
--
D
-
T
--
I
I
L
E
P
T
S
G
N
T
G
I
A
L
A
M
V
C
A
A
R
G
Y
R
C
V
L
T
M
P
E
T
M
S
L
E
R
R
M
L
L
R
A
Y
G
A
E
L
I
L
T
P
G
A
D
G
M
---
S
G
A
---
I
A
K
A
E
E
L
A
K
T
D
-
Q
-
R
Y
F
V
P
Q
-
Q
F
E
N
P
A
N
P
A
I
H
-
R
V
T
T
A
E
E
V
W
R
D
T
D
--
G
-
K
-
V
D
I
V
V
A
G
V
G
T
G
G
T
I
T
G
V
A
Q
V
I
K
--
E
R
--
K
-
P
S
A
R
F
V
A
V
E
P
-
A
A
S
P
-
V
-----
L
-
S
---
G
G
------
Q
----
K
G
P
H
P
I
Q
-
G
I
G
A
G
F
V
P
P
V
L
D
Q
D
L
V
D
E
I
I
T
V
G
N
E
D
A
L
N
V
A
R
R
L
A
R
E
E
G
L
L
V
G
I
S
S
G
A
-
A
T
V
A
A
L
Q
V
A
R
R
P--
E
-
N
-
A
G
-
K
L
I
V
V
V
L
P
D
F
G
E
R
Y
L
---------------
13
PsiBlast_PDB
87.78
52%
-69
- C3 -
2Q3D
2
CYSK_MYCTU
A:
[4-309]
-
M
S
I
A
E
D
I
T
Q
L
I
G
R
T
P
L
V
R
L
R
R
V
-
T
---
D
G
A
-------
V
--
A
D
I
V
A
--
K
L
E
F
F
N
P
A
N
S
V
K
D
R
I
G
V
A
M
L
Q
A
A
E
Q
A
G
L
I
K
P
--
D
-
T
--
I
I
L
E
P
T
S
G
N
T
G
I
A
L
A
M
V
C
A
A
R
G
Y
R
C
V
L
T
M
P
E
T
M
S
L
E
R
R
M
L
L
R
A
Y
G
A
E
L
I
L
T
P
G
A
D
G
M
---
S
G
A
---
I
A
K
A
E
E
L
A
K
T
D
-
Q
-
R
Y
F
V
P
Q
-
Q
F
E
N
P
A
N
P
A
I
H
-
R
V
T
T
A
E
E
V
W
R
D
T
D
--
G
-
K
-
V
D
I
V
V
A
G
V
G
T
G
G
T
I
T
G
V
A
Q
V
I
K
--
E
R
--
K
-
P
S
A
R
F
V
A
V
E
P
-
A
A
S
P
-
V
-----
L
-
S
---
G
G
------
Q
----
K
G
P
H
P
I
Q
-
G
I
G
A
G
F
V
P
P
V
L
D
Q
D
L
V
D
E
I
I
T
V
G
N
E
D
A
L
N
V
A
R
R
L
A
R
E
E
G
L
L
V
G
I
S
S
G
A
-
A
T
V
A
A
L
Q
V
A
R
R
P--
E
-
N
-
A
G
-
K
L
I
V
V
V
L
P
D
F
G
E
R
Y
L
S
---
T
---
P
L
F
A
---
114
HHSearch
85.85
58%
-96
- C3 -
2EGU
-
?
A:
[1-305]
M
A
R
T
V
N
S
I
T
E
L
I
G
D
T
P
A
V
K
L
N
R
I
-
V
---
D
E
D
-------
S
--
A
D
V
Y
L
--
K
L
E
F
M
N
P
G
S
S
V
K
D
R
I
A
L
A
M
I
E
A
A
E
K
A
G
K
L
K
P
--
G
-
D
--
T
I
V
E
P
T
S
G
N
T
G
I
G
L
A
M
V
A
A
A
K
G
Y
K
A
V
L
V
M
P
D
T
M
S
L
E
R
R
N
L
L
R
A
Y
G
A
E
L
V
L
T
P
G
A
Q
G
M
---
R
G
A
---
I
A
K
A
E
E
L
V
R
E
--
H
-
G
Y
F
M
P
----------------
T
T
G
K
E
I
V
---
E
Q
M
G
-
D
Q
L
D
A
F
V
A
G
V
G
T
G
G
T
I
T
G
A
G
K
V
L
R
--
E
A
--
Y
-
P
N
I
K
I
Y
A
V
E
P
-
A
D
--------------------------------------------
D
I
L
D
T
S
I
Y
D
G
V
I
T
V
T
T
E
E
A
F
A
A
A
R
R
A
A
R
E
E
G
I
L
G
G
I
S
S
G
A
-
A
I
H
A
A
L
K
V
A
K
E
---
L
-
G
-
K
G
-
K
K
V
L
A
I
I
P
S
N
G
E
R
Y
L
S
---
T
---
P
L
Y
Q
---
55
PsiBlast_CBE
85.66
46%
-79
- C3 -
3X43
1
DCSD_STRLA
C:
[9-303]
---------
D
T
I
G
R
T
P
I
V
R
L
Q
R
M
-
A
---
P
E
H
-------
T
--
S
-
V
Y
V
--
K
V
E
S
F
N
P
G
G
S
V
K
D
R
L
A
L
S
V
V
L
D
A
E
A
K
G
L
L
K
P
--
G
-
D
--
T
I
V
E
C
T
S
G
N
V
G
I
A
L
A
M
V
A
A
A
R
G
Y
R
F
V
A
V
M
G
D
T
Y
S
V
E
R
R
K
L
I
R
A
Y
G
G
K
L
V
L
F
P
G
H
L
G
S
---
K
G
G
---
N
L
I
A
D
E
L
A
E
K
Y
---
G
W
F
R
A
R
-
Q
F
D
N
P
A
N
P
S
Y
H
-
R
E
T
T
A
S
E
I
--
L
A
D
F
A
G
-
K
R
L
D
H
F
V
T
G
F
G
T
T
G
T
L
T
G
V
G
Q
M
L
R
--
V
A
--
R
-
P
E
V
R
V
V
A
L
E
P
-
S
N
A
A
-
M
-----
L
-
A
---
R
G
------
E
----
W
S
P
H
Q
I
Q
-
G
L
A
P
N
F
V
P
G
V
L
D
R
S
V
I
D
D
L
V
T
M
D
E
V
T
A
R
D
T
S
R
R
L
A
A
E
E
G
I
F
A
G
I
S
A
G
A
-
T
V
A
T
A
L
S
I
A
E
H
---
A
-
P
-
E
G
-
T
V
L
L
A
M
L
P
D
T
G
E
R
Y
L
S
---
T
---
F
L
F
----
15
PsiBlast_PDB
85.30
52%
-80
- C3 -
2Q3C
2
CYSK_MYCTU
A:
[4-303]
-
M
S
I
A
E
D
I
T
Q
L
I
G
R
T
P
L
V
R
L
R
R
V
-
T
---
D
G
A
-------
V
--
A
D
I
V
A
--
K
L
E
F
F
N
P
A
N
S
V
K
D
R
I
G
V
A
M
L
Q
A
A
E
Q
A
G
L
I
K
P
--
D
-
T
--
I
I
L
E
P
T
S
G
N
T
G
I
A
L
A
M
V
C
A
A
R
G
Y
R
C
V
L
T
M
P
E
T
M
S
L
E
R
R
M
L
L
R
A
Y
G
A
E
L
I
L
T
P
G
A
D
G
M
---
S
G
A
---
I
A
K
A
E
E
L
A
K
T
D
-
Q
-
R
Y
F
V
P
Q
-
Q
F
E
N
P
A
N
P
A
I
H
-
R
V
T
T
A
E
E
V
W
R
D
T
D
--
G
-
K
-
V
D
I
V
V
A
G
V
G
T
G
G
T
I
T
G
V
A
Q
V
I
K
--
E
R
--
K
-
P
S
A
R
F
V
A
V
E
P
-
A
A
S
P
-
V
-----
L
-
S
---
G
G
------
Q
----
K
G
P
H
P
I
Q
-
G
I
G
A
G
F
V
P
P
V
L
D
Q
D
L
V
D
E
I
I
T
V
G
N
E
D
A
L
N
V
A
R
R
L
A
R
E
E
G
L
L
V
G
I
S
S
G
A
-
A
T
V
A
A
L
Q
V
A
R
R
P--
E
-
N
-
A
G
-
K
L
I
V
V
V
L
P
D
F
G
E
R
Y
L
---------------
11
PsiBlast_PDB
85.28
57%
-98
- C3 -
2EGU
-
?
A:
[1-306]
M
A
R
T
V
N
S
I
T
E
L
I
G
D
T
P
A
V
K
L
N
R
I
-
V
---
D
E
D
-------
S
--
A
D
V
Y
L
--
K
L
E
F
M
N
P
G
S
S
V
K
D
R
I
A
L
A
M
I
E
A
A
E
K
A
G
K
L
K
P
--
G
-
D
--
T
I
V
E
P
T
S
G
N
T
G
I
G
L
A
M
V
A
A
A
K
G
Y
K
A
V
L
V
M
P
D
T
M
S
L
E
R
R
N
L
L
R
A
Y
G
A
E
L
V
L
T
P
G
A
Q
G
M
---
R
G
A
---
I
A
K
A
E
E
L
V
R
E
--
H
-
G
Y
F
M
P
----------------
T
T
G
K
E
I
---
V
E
Q
M
G
-
D
Q
L
D
A
F
V
A
G
V
G
T
G
G
T
I
T
G
A
G
K
V
L
R
--
E
A
--
Y
-
P
N
I
K
I
Y
A
V
E
P
-
A
D
--------------------------------------------
D
I
L
D
T
S
I
Y
D
G
V
I
T
V
T
T
E
E
A
F
A
A
A
R
R
A
A
R
E
E
G
I
L
G
G
I
S
S
G
A
-
A
I
H
A
A
L
K
V
A
K
E
---
L
-
G
-
K
G
-
K
K
V
L
A
I
I
P
S
N
G
E
R
Y
L
S
---
T
---
P
L
Y
Q
F
--
17
PsiBlast_PDB
84.98
53%
-98
- C3 -
4I1Y
2
?
A:
[5-301]
-
M
T
I
A
E
N
I
A
Q
L
I
G
G
T
P
L
V
R
L
R
R
V
-
T
---
D
G
A
-------
A
--
A
D
V
V
A
--
K
L
E
S
F
N
P
A
G
S
I
K
D
R
I
G
V
A
M
I
D
A
A
E
K
A
G
L
I
K
P
--
D
-
T
--
I
I
L
E
P
T
S
G
N
T
G
I
A
L
A
M
V
S
A
A
R
G
Y
K
C
V
L
T
M
P
D
T
M
S
I
E
R
R
M
L
L
R
A
Y
G
A
E
L
V
L
T
P
G
A
E
G
M
---
A
G
A
---
I
A
K
A
E
E
L
A
K
T
D
-
D
-
R
Y
F
I
P
Q
-------
N
P
A
V
H
-
A
V
T
T
A
E
E
V
W
R
D
T
D
--
G
-
K
-
V
D
I
F
V
S
G
V
G
T
G
G
T
I
T
G
V
A
Q
V
I
K
--
Q
R
--
R
-
P
S
A
Q
F
V
A
V
E
P
--------------------------------------------------
D
L
A
L
V
D
E
V
I
T
V
G
N
D
D
A
L
E
L
A
R
R
M
A
T
E
E
G
L
L
F
G
I
S
S
G
A
-
A
V
W
A
A
R
E
L
A
H
R
P--
E
-
N
-
A
G
-
K
L
I
V
V
V
L
P
D
F
G
E
------------------
31
PsiBlast_CBE
84.71
53%
-104
- C3 -
4I1Y
2
?
B:
[5-301]
-
M
T
I
A
E
N
I
A
Q
L
I
G
G
T
P
L
V
R
L
R
R
V
-
T
---
D
G
A
-------
A
--
A
D
V
V
A
--
K
L
E
S
F
N
P
A
G
S
I
K
D
R
I
G
V
A
M
I
D
A
A
E
K
A
G
L
I
K
P
--
D
-
T
--
I
I
L
E
P
T
--
N
T
G
I
A
L
A
M
V
S
A
A
R
G
Y
K
C
V
L
T
M
P
D
T
M
S
I
E
R
R
M
L
L
R
A
Y
G
A
E
L
V
L
T
P
G
A
E
G
M
---
A
G
A
---
I
A
K
A
E
E
L
A
K
T
D
-
D
-
R
Y
F
I
P
Q
-------
N
P
A
V
H
-
A
V
T
T
A
E
E
V
W
R
D
T
D
--
G
-
K
-
V
D
I
F
V
S
G
V
G
T
G
G
T
I
T
G
V
A
Q
V
I
K
--
Q
R
--
R
-
P
S
A
Q
F
V
A
V
E
P
-
A
-----------------------------------------------
L
D
L
A
L
V
D
E
V
I
T
V
G
N
D
D
A
L
E
L
A
R
R
M
A
T
E
E
G
L
L
F
G
I
S
S
G
A
-
A
V
W
A
A
R
E
L
A
H
R
P--
E
-
N
-
A
G
-
K
L
I
V
V
V
L
P
D
F
G
E
------------------
57
PsiBlast_CBE
84.47
46%
-77
- C3 -
3X43
1
DCSD_STRLA
A:
[9-303]
---------
D
T
I
G
R
T
P
I
V
R
L
Q
R
M
-
A
---
P
E
H
-------
T
--
S
-
V
Y
V
--
K
V
E
S
F
N
P
G
G
S
V
K
D
R
L
A
L
S
V
V
L
D
A
E
A
K
G
L
L
K
P
--
G
-
D
--
T
I
V
E
C
T
S
G
N
V
G
I
A
L
A
M
V
A
A
A
R
G
Y
R
F
V
A
V
M
G
D
T
Y
S
V
E
R
R
K
L
I
R
A
Y
G
G
K
L
V
L
F
P
G
H
L
G
S
---
K
G
G
---
N
L
I
A
D
E
L
A
E
K
Y
---
G
W
F
R
A
R
-
Q
F
D
N
P
A
N
P
S
Y
H
-
R
E
T
T
A
S
E
I
--
L
A
D
F
A
G
-
K
R
L
D
H
F
V
T
G
F
G
T
T
G
T
L
T
G
V
G
Q
M
L
R
--
V
A
--
R
-
P
E
V
R
V
V
A
L
E
P
-
S
N
A
A
-
M
-----
L
-
A
---
R
G
------
E
----
W
S
P
H
Q
I
Q
-
G
L
A
P
N
F
V
P
G
V
L
D
R
S
V
I
D
D
L
V
T
M
D
E
V
T
A
R
D
T
S
R
R
L
A
A
E
E
G
I
F
A
G
I
S
A
G
A
-
T
V
A
T
A
L
S
I
A
E
H
---
A
-
P
-
E
G
-
T
V
L
L
A
M
L
P
D
T
G
E
R
Y
L
S
---
T
---
F
L
F
----
52
PsiBlast_CBE
84.34
46%
-78
- C3 -
3X43
1
DCSD_STRLA
F:
[9-303]
---------
D
T
I
G
R
T
P
I
V
R
L
Q
R
M
-
A
---
P
E
H
-------
T
--
S
-
V
Y
V
--
K
V
E
S
F
N
P
G
G
S
V
K
D
R
L
A
L
S
V
V
L
D
A
E
A
K
G
L
L
K
P
--
G
-
D
--
T
I
V
E
C
T
S
G
N
V
G
I
A
L
A
M
V
A
A
A
R
G
Y
R
F
V
A
V
M
G
D
T
Y
S
V
E
R
R
K
L
I
R
A
Y
G
G
K
L
V
L
F
P
G
H
L
G
S
---
K
G
G
---
N
L
I
A
D
E
L
A
E
K
Y
---
G
W
F
R
A
R
-
Q
F
D
N
P
A
N
P
S
Y
H
-
R
E
T
T
A
S
E
I
--
L
A
D
F
A
G
-
K
R
L
D
H
F
V
T
G
F
G
T
T
G
T
L
T
G
V
G
Q
M
L
R
--
V
A
--
R
-
P
E
V
R
V
V
A
L
E
P
-
S
N
A
A
-
M
-----
L
-
A
---
R
G
------
E
----
W
S
P
H
Q
I
Q
-
G
L
A
P
N
F
V
P
G
V
L
D
R
S
V
I
D
D
L
V
T
M
D
E
V
T
A
R
D
T
S
R
R
L
A
A
E
E
G
I
F
A
G
I
S
A
G
A
-
T
V
A
T
A
L
S
I
A
E
H
---
A
-
P
-
E
G
-
T
V
L
L
A
M
L
P
D
T
G
E
R
Y
L
S
---
T
---
F
L
F
----
56
PsiBlast_CBE
83.69
46%
-78
- C3 -
3X43
1
DCSD_STRLA
B:
[9-303]
---------
D
T
I
G
R
T
P
I
V
R
L
Q
R
M
-
A
---
P
E
H
-------
T
--
S
-
V
Y
V
--
K
V
E
S
F
N
P
G
G
S
V
K
D
R
L
A
L
S
V
V
L
D
A
E
A
K
G
L
L
K
P
--
G
-
D
--
T
I
V
E
C
T
S
G
N
V
G
I
A
L
A
M
V
A
A
A
R
G
Y
R
F
V
A
V
M
G
D
T
Y
S
V
E
R
R
K
L
I
R
A
Y
G
G
K
L
V
L
F
P
G
H
L
G
S
---
K
G
G
---
N
L
I
A
D
E
L
A
E
K
Y
---
G
W
F
R
A
R
-
Q
F
D
N
P
A
N
P
S
Y
H
-
R
E
T
T
A
S
E
I
--
L
A
D
F
A
G
-
K
R
L
D
H
F
V
T
G
F
G
T
T
G
T
L
T
G
V
G
Q
M
L
R
--
V
A
--
R
-
P
E
V
R
V
V
A
L
E
P
-
S
N
A
A
-
M
-----
L
-
A
---
R
G
------
E
----
W
S
P
H
Q
I
Q
-
G
L
A
P
N
F
V
P
G
V
L
D
R
S
V
I
D
D
L
V
T
M
D
E
V
T
A
R
D
T
S
R
R
L
A
A
E
E
G
I
F
A
G
I
S
A
G
A
-
T
V
A
T
A
L
S
I
A
E
H
---
A
-
P
-
E
G
-
T
V
L
L
A
M
L
P
D
T
G
E
R
Y
L
S
---
T
---
F
L
F
----
53
PsiBlast_CBE
83.48
46%
-74
- C3 -
3X43
1
DCSD_STRLA
E:
[9-303]
---------
D
T
I
G
R
T
P
I
V
R
L
Q
R
M
-
A
---
P
E
H
-------
T
--
S
-
V
Y
V
--
K
V
E
S
F
N
P
G
G
S
V
K
D
R
L
A
L
S
V
V
L
D
A
E
A
K
G
L
L
K
P
--
G
-
D
--
T
I
V
E
C
T
S
G
N
V
G
I
A
L
A
M
V
A
A
A
R
G
Y
R
F
V
A
V
M
G
D
T
Y
S
V
E
R
R
K
L
I
R
A
Y
G
G
K
L
V
L
F
P
G
H
L
G
S
---
K
G
G
---
N
L
I
A
D
E
L
A
E
K
Y
---
G
W
F
R
A
R
-
Q
F
D
N
P
A
N
P
S
Y
H
-
R
E
T
T
A
S
E
I
--
L
A
D
F
A
G
-
K
R
L
D
H
F
V
T
G
F
G
T
T
G
T
L
T
G
V
G
Q
M
L
R
--
V
A
--
R
-
P
E
V
R
V
V
A
L
E
P
-
S
N
A
A
-
M
-----
L
-
A
---
R
G
------
E
----
W
S
P
H
Q
I
Q
-
G
L
A
P
N
F
V
P
G
V
L
D
R
S
V
I
D
D
L
V
T
M
D
E
V
T
A
R
D
T
S
R
R
L
A
A
E
E
G
I
F
A
G
I
S
A
G
A
-
T
V
A
T
A
L
S
I
A
E
H
---
A
-
P
-
E
G
-
T
V
L
L
A
M
L
P
D
T
G
E
R
Y
L
S
---
T
---
F
L
F
----
51
PsiBlast_CBE
83.37
46%
-78
- C3 -
3X43
1
DCSD_STRLA
G:
[9-303]
---------
D
T
I
G
R
T
P
I
V
R
L
Q
R
M
-
A
---
P
E
H
-------
T
--
S
-
V
Y
V
--
K
V
E
S
F
N
P
G
G
S
V
K
D
R
L
A
L
S
V
V
L
D
A
E
A
K
G
L
L
K
P
--
G
-
D
--
T
I
V
E
C
T
S
G
N
V
G
I
A
L
A
M
V
A
A
A
R
G
Y
R
F
V
A
V
M
G
D
T
Y
S
V
E
R
R
K
L
I
R
A
Y
G
G
K
L
V
L
F
P
G
H
L
G
S
---
K
G
G
---
N
L
I
A
D
E
L
A
E
K
Y
---
G
W
F
R
A
R
-
Q
F
D
N
P
A
N
P
S
Y
H
-
R
E
T
T
A
S
E
I
--
L
A
D
F
A
G
-
K
R
L
D
H
F
V
T
G
F
G
T
T
G
T
L
T
G
V
G
Q
M
L
R
--
V
A
--
R
-
P
E
V
R
V
V
A
L
E
P
-
S
N
A
A
-
M
-----
L
-
A
---
R
G
------
E
----
W
S
P
H
Q
I
Q
-
G
L
A
P
N
F
V
P
G
V
L
D
R
S
V
I
D
D
L
V
T
M
D
E
V
T
A
R
D
T
S
R
R
L
A
A
E
E
G
I
F
A
G
I
S
A
G
A
-
T
V
A
T
A
L
S
I
A
E
H
---
A
-
P
-
E
G
-
T
V
L
L
A
M
L
P
D
T
G
E
R
Y
L
S
---
T
---
F
L
F
----
81
PsiBlast_CBE
83.29
46%
-70
- C3 -
3X44
1
DCSD_STRLA
A:
[9-303]
---------
D
T
I
G
R
T
P
I
V
R
L
Q
R
M
-
A
---
P
E
H
-------
T
--
S
-
V
Y
V
--
K
V
E
S
F
N
P
G
G
S
V
A
D
R
L
A
L
S
V
V
L
D
A
E
A
K
G
L
L
K
P
--
G
-
D
--
T
I
V
E
C
T
S
G
N
V
G
I
A
L
A
M
V
A
A
A
R
G
Y
R
F
V
A
V
M
G
D
T
Y
S
V
E
R
R
K
L
I
R
A
Y
G
G
K
L
V
L
F
P
G
H
L
G
S
---
K
G
G
---
N
L
I
A
D
E
L
A
E
K
Y
---
G
W
F
R
A
R
-
Q
F
D
N
P
A
N
P
S
Y
H
-
R
E
T
T
A
S
E
I
--
L
A
D
F
A
G
-
K
R
L
D
H
F
V
T
G
F
G
T
T
G
T
L
T
G
V
G
Q
M
L
R
--
V
A
--
R
-
P
E
V
R
V
V
A
L
E
P
-
S
N
A
A
-
M
-----
L
-
A
---
R
G
------
E
----
W
S
P
H
Q
I
Q
-
G
L
A
P
N
F
V
P
G
V
L
D
R
S
V
I
D
D
L
V
T
M
D
E
V
T
A
R
D
T
S
R
R
L
A
A
E
E
G
I
F
A
G
I
S
A
G
A
-
T
V
A
T
A
L
S
I
A
E
H
---
A
-
P
-
E
G
-
T
V
L
L
A
M
L
P
D
T
G
E
R
Y
L
S
---
T
---
F
L
F
----
80
PsiBlast_CBE
82.89
46%
-71
- C3 -
3X44
1
DCSD_STRLA
B:
[9-303]
---------
D
T
I
G
R
T
P
I
V
R
L
Q
R
M
-
A
---
P
E
H
-------
T
--
S
-
V
Y
V
--
K
V
E
S
F
N
P
G
G
S
V
A
D
R
L
A
L
S
V
V
L
D
A
E
A
K
G
L
L
K
P
--
G
-
D
--
T
I
V
E
C
T
S
G
N
V
G
I
A
L
A
M
V
A
A
A
R
G
Y
R
F
V
A
V
M
G
D
T
Y
S
V
E
R
R
K
L
I
R
A
Y
G
G
K
L
V
L
F
P
G
H
L
G
S
---
K
G
G
---
N
L
I
A
D
E
L
A
E
K
Y
---
G
W
F
R
A
R
-
Q
F
D
N
P
A
N
P
S
Y
H
-
R
E
T
T
A
S
E
I
--
L
A
D
F
A
G
-
K
R
L
D
H
F
V
T
G
F
G
T
T
G
T
L
T
G
V
G
Q
M
L
R
--
V
A
--
R
-
P
E
V
R
V
V
A
L
E
P
-
S
N
A
A
-
M
-----
L
-
A
---
R
G
------
E
----
W
S
P
H
Q
I
Q
-
G
L
A
P
N
F
V
P
G
V
L
D
R
S
V
I
D
D
L
V
T
M
D
E
V
T
A
R
D
T
S
R
R
L
A
A
E
E
G
I
F
A
G
I
S
A
G
A
-
T
V
A
T
A
L
S
I
A
E
H
---
A
-
P
-
E
G
-
T
V
L
L
A
M
L
P
D
T
G
E
R
Y
L
S
---
T
---
F
L
F
----
50
PsiBlast_CBE
82.89
46%
-74
- C3 -
3X43
1
DCSD_STRLA
H:
[9-303]
---------
D
T
I
G
R
T
P
I
V
R
L
Q
R
M
-
A
---
P
E
H
-------
T
--
S
-
V
Y
V
--
K
V
E
S
F
N
P
G
G
S
V
K
D
R
L
A
L
S
V
V
L
D
A
E
A
K
G
L
L
K
P
--
G
-
D
--
T
I
V
E
C
T
S
G
N
V
G
I
A
L
A
M
V
A
A
A
R
G
Y
R
F
V
A
V
M
G
D
T
Y
S
V
E
R
R
K
L
I
R
A
Y
G
G
K
L
V
L
F
P
G
H
L
G
S
---
K
G
G
---
N
L
I
A
D
E
L
A
E
K
Y
---
G
W
F
R
A
R
-
Q
F
D
N
P
A
N
P
S
Y
H
-
R
E
T
T
A
S
E
I
--
L
A
D
F
A
G
-
K
R
L
D
H
F
V
T
G
F
G
T
T
G
T
L
T
G
V
G
Q
M
L
R
--
V
A
--
R
-
P
E
V
R
V
V
A
L
E
P
-
S
N
A
A
-
M
-----
L
-
A
---
R
G
------
E
----
W
S
P
H
Q
I
Q
-
G
L
A
P
N
F
V
P
G
V
L
D
R
S
V
I
D
D
L
V
T
M
D
E
V
T
A
R
D
T
S
R
R
L
A
A
E
E
G
I
F
A
G
I
S
A
G
A
-
T
V
A
T
A
L
S
I
A
E
H
---
A
-
P
-
E
G
-
T
V
L
L
A
M
L
P
D
T
G
E
R
Y
L
S
---
T
---
F
L
F
----
54
PsiBlast_CBE
82.62
46%
-74
- C3 -
3X43
1
DCSD_STRLA
D:
[9-303]
---------
D
T
I
G
R
T
P
I
V
R
L
Q
R
M
-
A
---
P
E
H
-------
T
--
S
-
V
Y
V
--
K
V
E
S
F
N
P
G
G
S
V
K
D
R
L
A
L
S
V
V
L
D
A
E
A
K
G
L
L
K
P
--
G
-
D
--
T
I
V
E
C
T
S
G
N
V
G
I
A
L
A
M
V
A
A
A
R
G
Y
R
F
V
A
V
M
G
D
T
Y
S
V
E
R
R
K
L
I
R
A
Y
G
G
K
L
V
L
F
P
G
H
L
G
S
---
K
G
G
---
N
L
I
A
D
E
L
A
E
K
Y
---
G
W
F
R
A
R
-
Q
F
D
N
P
A
N
P
S
Y
H
-
R
E
T
T
A
S
E
I
--
L
A
D
F
A
G
-
K
R
L
D
H
F
V
T
G
F
G
T
T
G
T
L
T
G
V
G
Q
M
L
R
--
V
A
--
R
-
P
E
V
R
V
V
A
L
E
P
-
S
N
A
A
-
M
-----
L
-
A
---
R
G
------
E
----
W
S
P
H
Q
I
Q
-
G
L
A
P
N
F
V
P
G
V
L
D
R
S
V
I
D
D
L
V
T
M
D
E
V
T
A
R
D
T
S
R
R
L
A
A
E
E
G
I
F
A
G
I
S
A
G
A
-
T
V
A
T
A
L
S
I
A
E
H
---
A
-
P
-
E
G
-
T
V
L
L
A
M
L
P
D
T
G
E
R
Y
L
S
---
T
---
F
L
F
----
107
PsiBlast_CBE
81.32
43%
-79
- C3 -
4OFX
2
?
A:
[5-312]
---
V
L
D
N
I
L
Q
V
I
G
K
T
P
V
V
R
L
H
R
I
-
G
---
Q
S
L
-------
P
--
C
E
L
Y
G
--
K
C
E
F
L
N
P
G
G
S
V
K
D
R
I
G
A
A
M
I
E
S
A
E
K
Q
G
K
I
K
P
--
G
-
D
--
T
L
I
E
P
T
S
G
N
T
G
I
G
I
A
L
A
G
A
V
K
G
Y
R
V
I
I
T
M
P
E
K
M
S
H
E
K
Q
V
V
L
E
A
L
G
A
T
I
Y
R
T
P
--------
E
S
H
---
I
S
L
A
K
R
L
N
Q
E
I
-
P
-
N
S
Y
I
L
D
-
Q
Y
S
N
A
E
N
P
D
I
H
-
Y
Q
T
T
G
Q
E
I
---
L
D
D
M
G
-
E
N
L
S
M
V
V
M
G
V
G
T
G
G
T
I
I
G
V
A
K
K
L
K
--
E
V
--
N
-
P
S
I
Q
I
I
G
V
D
P
-
I
G
S
--
I
-----
L
-
G
---
G
G
------
D
------------------------
N
N
L
I
D
E
Y
I
K
I
N
D
K
D
S
F
L
M
A
R
R
L
I
R
E
E
G
L
L
V
G
G
S
S
G
S
-
A
V
W
A
A
C
Q
A
A
Q
R
---
L
-
K
-
E
G
-
E
R
C
L
V
I
L
P
D
A
I
R
N
Y
L
T
---
K
FVD
D
A
W
----
117
HHSearch
80.29
50%
-9
- C3 -
4AEC
3
CYSKM_ARATH
A:
[112-418]
--
N
I
A
D
N
V
S
Q
L
I
G
K
T
P
M
V
Y
L
N
S
I
-
A
---
K
G
C
-------
V
--
A
N
I
A
A
--
K
L
E
I
M
E
P
C
C
S
V
K
D
R
I
G
Y
S
M
V
T
D
A
E
Q
K
G
F
I
S
P
--
G
K
S
--
V
L
V
E
P
T
S
G
N
T
G
I
G
L
A
F
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
S
M
S
M
E
R
R
V
L
L
K
A
F
G
A
E
L
V
L
T
D
P
A
K
G
M
---
T
G
A
---
V
Q
K
A
E
E
I
L
K
N
T
-
P
-
D
A
Y
M
L
Q
-
Q
F
D
N
P
A
N
P
K
I
H
-
Y
E
T
T
G
P
E
I
W
---
D
D
T
K
-
G
K
V
D
I
F
V
A
G
I
G
T
G
G
T
I
T
G
V
G
R
F
I
K
--
E
K
--
N
-
P
K
T
Q
V
I
G
V
E
P
-
T
E
S
D
-
I
-----
L
-
S
---
G
G
------
K
----
P
G
P
H
K
I
Q
-
G
I
G
A
G
F
I
P
K
N
L
D
Q
K
I
M
D
E
V
I
A
I
S
S
E
E
A
I
E
T
A
K
Q
L
A
L
K
E
G
L
M
V
G
I
S
S
G
A
-
A
A
A
A
A
I
K
V
A
K
R
---
P
E
N
-
A
G
-
K
L
I
A
V
V
F
P
S
F
G
E
R
Y
L
S
---
T
---
P
L
F
Q
S
--
37
PsiBlast_CBE
80.26
49%
-6
- C3 -
4AEC
4
CYSKM_ARATH
B:
[111-419]
-
L
N
I
A
D
N
V
S
Q
L
I
G
K
T
P
M
V
Y
L
N
S
I
-
A
---
K
G
C
-------
V
--
A
N
I
A
A
--
K
L
E
I
M
E
P
C
C
S
V
K
D
R
I
G
Y
S
M
V
T
D
A
E
Q
K
G
F
I
S
P
--
G
K
S
--
V
L
V
E
P
T
S
G
N
T
G
I
G
L
A
F
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
S
M
S
M
E
R
R
V
L
L
K
A
F
G
A
E
L
V
L
T
D
P
A
K
G
M
---
T
G
A
---
V
Q
K
A
E
E
I
L
K
N
T
-
P
-
D
A
Y
M
L
Q
-
Q
F
D
N
P
A
N
P
K
I
H
-
Y
E
T
T
G
P
E
I
---
W
D
D
T
K
-
G
K
V
D
I
F
V
A
G
I
G
T
G
G
T
I
T
G
V
G
R
F
I
K
--
E
K
--
N
-
P
K
T
Q
V
I
G
V
E
P
-
T
E
S
D
-
I
-----
L
-
S
---
G
G
------
K
----
P
G
P
H
K
I
Q
-
G
I
G
A
G
F
I
P
K
N
L
D
Q
K
I
M
D
E
V
I
A
I
S
S
E
E
A
I
E
T
A
K
Q
L
A
L
K
E
G
L
M
V
G
I
S
S
G
A
-
A
A
A
A
A
I
K
V
A
K
R
P--
E
-
N
-
A
G
-
K
L
I
A
V
V
F
P
S
F
G
E
R
Y
L
S
---
T
---
P
L
F
Q
S
I
-
25
PsiBlast_PDB
80.16
49%
-10
- C3 -
4AEC
3
CYSKM_ARATH
A:
[111-419]
-
L
N
I
A
D
N
V
S
Q
L
I
G
K
T
P
M
V
Y
L
N
S
I
-
A
---
K
G
C
-------
V
--
A
N
I
A
A
--
K
L
E
I
M
E
P
C
C
S
V
K
D
R
I
G
Y
S
M
V
T
D
A
E
Q
K
G
F
I
S
P
--
G
K
S
--
V
L
V
E
P
T
S
G
N
T
G
I
G
L
A
F
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
S
M
S
M
E
R
R
V
L
L
K
A
F
G
A
E
L
V
L
T
D
P
A
K
G
M
---
T
G
A
---
V
Q
K
A
E
E
I
L
K
N
T
-
P
-
D
A
Y
M
L
Q
-
Q
F
D
N
P
A
N
P
K
I
H
-
Y
E
T
T
G
P
E
I
---
W
D
D
T
K
-
G
K
V
D
I
F
V
A
G
I
G
T
G
G
T
I
T
G
V
G
R
F
I
K
--
E
K
--
N
-
P
K
T
Q
V
I
G
V
E
P
-
T
E
S
D
-
I
-----
L
-
S
---
G
G
------
K
----
P
G
P
H
K
I
Q
-
G
I
G
A
G
F
I
P
K
N
L
D
Q
K
I
M
D
E
V
I
A
I
S
S
E
E
A
I
E
T
A
K
Q
L
A
L
K
E
G
L
M
V
G
I
S
S
G
A
-
A
A
A
A
A
I
K
V
A
K
R
P--
E
-
N
-
A
G
-
K
L
I
A
V
V
F
P
S
F
G
E
R
Y
L
S
---
T
---
P
L
F
Q
S
I
-
111
HHSearch
78.90
51%
-17
- C3 -
2Q3B
5
CYSK_MYCTU
A:
[4-303]
-
M
S
I
A
E
D
I
T
Q
L
I
G
R
T
P
L
V
R
L
R
R
V
-
T
---
D
G
A
-------
V
--
A
D
I
V
A
--
K
L
E
F
F
N
P
A
N
S
V
K
D
R
I
G
V
A
M
L
Q
A
A
E
Q
A
G
L
I
K
P
--
D
-
T
--
I
I
L
E
P
T
S
G
N
T
G
I
A
L
A
M
V
C
A
A
R
G
Y
R
C
V
L
T
M
P
E
T
M
S
L
E
R
R
M
L
L
R
A
Y
G
A
E
L
I
L
T
P
G
A
D
G
M
---
S
G
A
---
I
A
K
A
E
E
L
A
K
T
D
-
Q
-
R
Y
F
V
P
Q
-
Q
F
E
N
P
A
N
P
-
A
I
H
R
V
T
T
A
E
E
V
W
---
R
D
T
D
-
G
K
V
D
I
V
V
A
G
V
G
T
G
G
T
I
T
G
V
A
Q
V
I
K
--
E
R
--
K
-
P
S
A
R
F
V
A
V
E
P
-
A
A
S
P
V
L
-----
S
-
G
---
G
-------
Q
----
K
G
P
H
P
I
Q
-
G
I
G
A
G
F
V
P
P
V
L
D
Q
D
L
V
D
E
I
I
T
V
G
N
E
D
A
L
N
V
A
R
R
L
A
R
E
E
G
L
L
V
G
I
S
S
G
A
-
A
T
V
A
A
L
Q
V
A
R
R
P--
E
-
N
-
A
G
-
K
L
I
V
V
V
L
P
D
F
G
E
R
Y
L
---------------
115
HHSearch
78.47
45%
-38
- C3 -
3X44
1
DCSD_STRLA
A:
[2-305]
--
P
L
F
N
S
I
L
D
T
I
G
R
T
P
I
V
R
L
Q
R
M
-
A
---
P
E
--------
H
--
T
S
V
Y
V
--
K
V
E
S
F
N
P
G
G
S
V
A
D
R
L
A
L
S
V
V
L
D
A
E
A
K
G
L
L
K
P
--
G
-
D
--
T
I
V
E
C
T
S
G
N
V
G
I
A
L
A
M
V
A
A
A
R
G
Y
R
F
V
A
V
M
G
D
T
Y
S
V
E
R
R
K
L
I
R
A
Y
G
G
K
L
V
L
F
P
G
H
L
G
S
---
K
G
G
---
N
L
I
A
D
E
L
A
E
-
K
-
Y
-
G
W
F
R
A
R
-
Q
F
D
N
P
A
N
P
S
Y
H
-
R
E
T
T
A
S
E
I
L
---
A
D
F
A
G
K
R
L
D
H
F
V
T
G
F
G
T
T
G
T
L
T
G
V
G
Q
M
L
R
--
V
A
--
R
-
P
E
V
R
V
V
A
L
E
P
-
S
N
A
A
-
M
-----
L
-
A
---
R
G
------
E
----
W
S
P
H
Q
I
Q
-
G
L
A
P
N
F
V
P
G
V
L
D
R
S
V
I
D
D
L
V
T
M
D
E
V
T
A
R
D
T
S
R
R
L
A
A
E
E
G
I
F
A
G
I
S
A
G
A
-
T
V
A
T
A
L
S
I
A
E
H
---
A
-
P
-
E
G
-
T
V
L
L
A
M
L
P
D
T
G
E
R
Y
L
S
---
T
---
F
L
F
D
G
--
130
HHSearch
77.22
45%
-70
- C3 -
2V03
3
CYSM_ECOLI
A:
[3-294]
------
T
L
E
Q
T
I
G
N
T
P
L
V
K
L
Q
R
M
-
G
---
P
D
N
-------
G
--
S
E
V
W
L
--
K
L
E
G
N
N
P
A
G
S
V
K
D
R
A
A
L
S
M
I
V
E
A
E
K
R
G
E
I
K
P
--
G
-
D
--
V
L
I
E
A
T
S
G
N
T
G
I
A
L
A
M
I
A
A
L
K
G
Y
R
M
K
L
L
M
P
D
N
M
S
Q
E
R
R
A
A
M
R
A
Y
G
A
E
L
I
L
V
T
K
E
Q
G
M
---
E
G
A
---
R
D
L
A
L
E
M
A
N
R
--
G
-
E
G
K
L
L
D
-
Q
F
N
N
P
D
N
P
Y
A
H
-
Y
T
T
T
G
P
E
I
W
---
Q
Q
T
G
-
G
R
I
T
H
F
V
S
S
M
G
T
T
G
T
I
T
G
V
S
R
F
M
R
--
E
Q
--
S
-
K
P
V
T
I
V
G
L
Q
P
-
E
E
G
S
-
S
-----
I
-
P
---
G
-----------------
I
R
-
R
W
P
T
E
Y
L
P
G
I
F
N
A
S
L
V
D
E
V
L
D
I
H
Q
R
D
A
E
N
T
M
R
E
L
A
V
R
E
G
I
F
C
G
V
S
S
G
G
-
A
V
A
G
A
L
R
V
A
A
A
---
N
---
P
D
-
A
V
V
V
A
I
I
C
D
R
G
D
R
Y
L
S
---
T
---
G
V
F
G
E
--
28
PsiBlast_PDB
76.76
48%
-14
- C3 -
1Z7Y
1
CYSK1_ARATH
A:
[4-308]
--
R
I
A
K
D
V
T
E
L
I
G
N
T
P
L
V
Y
L
N
N
V
-
A
---
E
G
C
-------
V
--
G
R
V
A
A
--
K
L
E
M
M
E
P
C
S
S
V
A
D
R
I
G
F
S
M
I
S
D
A
E
K
K
G
L
I
K
P
--
G
E
S
--
V
L
I
E
P
T
S
G
N
T
G
V
G
L
A
F
T
A
A
A
K
G
Y
K
L
I
I
T
M
P
A
S
M
S
T
E
R
R
I
I
L
L
A
F
G
V
E
L
V
L
T
D
P
A
K
G
M
---
K
G
A
---
I
A
K
A
E
E
I
L
A
K
T
-
P
-
N
G
Y
M
L
Q
-
Q
F
E
N
P
A
N
P
K
I
H
-
Y
E
T
T
G
P
E
I
W
K
G
T
---
G
-
G
K
I
D
G
F
V
S
G
I
G
T
G
G
T
I
T
G
A
G
K
Y
L
K
--
E
Q
--
N
-
A
N
V
K
L
Y
G
V
E
P
-
V
E
S
A
-
I
-----
L
-
S
---
G
G
------
K
----
P
G
P
H
K
I
Q
-
G
I
G
A
G
F
I
P
S
V
L
N
V
D
L
I
D
E
V
V
Q
V
S
S
D
E
S
I
D
M
A
R
Q
L
A
L
K
E
G
L
L
V
G
I
S
S
G
A
-
A
A
A
A
A
I
K
L
A
Q
R
P--
E
-
N
-
A
G
-
K
L
F
V
A
I
F
P
S
F
G
E
R
Y
L
S
---
T
---
V
L
F
----
110
PsiBlast_CBE
76.32
45%
3
- C3 -
1D6S
2
CYSK_SALTY
A:
[2-312]
--
K
I
Y
E
D
N
S
L
T
I
G
H
T
P
L
V
R
L
N
R
I
-------
G
-------
N
--
G
R
I
L
A
--
K
V
E
S
R
N
P
S
F
S
V
A
C
R
I
G
A
N
M
I
W
D
A
E
K
R
G
V
L
K
P
--
G
-
V
--
E
L
V
E
P
T
N
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
L
T
L
T
M
P
E
T
M
S
I
E
R
R
K
L
L
K
A
L
G
A
N
L
V
L
T
E
G
A
K
G
M
---
K
G
A
---
I
Q
K
A
E
E
I
V
A
S
D
-
P
-
Q
K
Y
L
L
L
Q
Q
F
S
N
P
A
N
P
E
I
H
-
E
K
T
T
G
P
E
I
---
W
E
D
T
D
-
G
Q
V
D
V
F
I
S
G
V
G
T
G
G
T
L
T
G
V
T
R
Y
I
K
GT
K
G
--
K
-
T
D
L
I
T
V
A
V
E
P
-
T
D
S
P
-
V
-----
I
-
A
---
Q
A
L
A
GE
E
I
K
----
P
G
P
H
K
I
Q
-
G
I
G
A
G
F
I
P
G
N
L
D
L
K
L
I
D
K
V
V
G
I
T
N
E
E
A
I
S
T
A
R
R
L
M
E
E
E
G
I
L
A
G
I
S
S
G
A
-
A
V
A
A
A
L
K
L
Q
E
D
---
E
-
S
F
T
N
-
K
N
I
V
V
I
L
P
S
S
G
E
R
Y
L
S
---
T
---
A
L
F
A
---
109
PsiBlast_CBE
76.01
45%
3
- C3 -
1D6S
2
CYSK_SALTY
B:
[2-312]
--
K
I
Y
E
D
N
S
L
T
I
G
H
T
P
L
V
R
L
N
R
I
-------
G
-------
N
--
G
R
I
L
A
--
K
V
E
S
R
N
P
S
F
S
V
A
C
R
I
G
A
N
M
I
W
D
A
E
K
R
G
V
L
K
P
--
G
-
V
--
E
L
V
E
P
T
N
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
L
T
L
T
M
P
E
T
M
S
I
E
R
R
K
L
L
K
A
L
G
A
N
L
V
L
T
E
G
A
K
G
M
---
K
G
A
---
I
Q
K
A
E
E
I
V
A
S
D
-
P
-
Q
K
Y
L
L
L
Q
Q
F
S
N
P
A
N
P
E
I
H
-
E
K
T
T
G
P
E
I
---
W
E
D
T
D
-
G
Q
V
D
V
F
I
S
G
V
G
T
G
G
T
L
T
G
V
T
R
Y
I
K
GT
K
G
--
K
-
T
D
L
I
T
V
A
V
E
P
-
T
D
S
P
-
V
-----
I
-
A
---
Q
A
LAGEEI
K
----
P
G
P
H
K
I
Q
-
G
I
G
A
G
F
I
P
G
N
L
D
L
K
L
I
D
K
V
V
G
I
T
N
E
E
A
I
S
T
A
R
R
L
M
E
E
E
G
I
L
A
G
I
S
S
G
A
-
A
V
A
A
A
L
K
L
Q
E
D
---
E
-
S
F
T
N
-
K
N
I
V
V
I
L
P
S
S
G
E
R
Y
L
S
---
T
---
A
L
F
A
---
118
HHSearch
75.80
49%
-6
- C3 -
1Z7W
2
CYSK1_ARATH
A:
[4-310]
--
R
I
A
K
D
V
T
E
L
I
G
N
T
P
L
V
Y
L
N
N
V
-
A
---
E
G
C
-------
V
--
G
R
V
A
A
--
K
L
E
M
M
E
P
C
S
S
V
K
D
R
I
G
F
S
M
I
S
D
A
E
K
K
G
L
I
K
P
--
G
E
S
--
V
L
I
E
P
T
S
G
N
T
G
V
G
L
A
F
T
A
A
A
K
G
Y
K
L
I
I
T
M
P
A
S
M
S
T
E
R
R
I
I
L
L
A
F
G
V
E
L
V
L
T
D
P
A
K
G
M
---
K
G
A
---
I
A
K
A
E
E
I
L
A
K
T
-
P
-
N
G
Y
M
L
Q
-
Q
F
E
N
P
A
N
P
K
I
H
-
Y
E
T
T
G
P
E
I
W
---
K
G
T
G
-
G
K
I
D
G
F
V
S
G
I
G
T
G
G
T
I
T
G
A
G
K
Y
L
K
--
E
Q
--
N
-
A
N
V
K
L
Y
G
V
E
P
-
V
E
S
A
-
I
-----
L
-
S
---
G
G
------
K
----
P
G
P
H
K
I
Q
-
G
I
G
A
G
F
I
P
S
V
L
N
V
D
L
I
D
E
V
V
Q
V
S
S
D
E
S
I
D
M
A
R
Q
L
A
L
K
E
G
L
L
V
G
I
S
S
G
A
-
A
A
A
A
A
I
K
L
A
Q
R
---
P
E
N
-
A
G
-
K
L
F
V
A
I
F
P
S
F
G
E
R
Y
L
S
---
T
---
V
L
F
D
A
--
27
PsiBlast_PDB
75.49
48%
-5
- C3 -
2ISQ
3
CYSK1_ARATH
A:
[2-306]
--
R
I
A
K
D
V
T
E
L
I
G
N
T
P
L
V
Y
L
N
N
V
-
A
---
E
G
C
-------
V
--
G
R
V
A
A
--
K
L
E
M
M
E
P
C
S
S
V
K
D
R
I
G
F
S
M
I
S
D
A
E
K
K
G
L
I
K
P
--
G
E
S
--
V
L
I
E
P
T
S
G
N
T
G
V
G
L
A
F
T
A
A
A
K
G
Y
K
L
I
I
T
M
P
A
S
M
S
T
E
R
R
I
I
L
L
A
F
G
V
E
L
V
L
T
D
P
A
K
G
M
---
K
G
A
---
I
A
K
A
E
E
I
L
A
K
T
-
P
-
N
G
Y
M
L
Q
-
Q
F
E
N
P
A
N
P
K
I
H
-
Y
E
T
T
G
P
E
I
W
K
G
T
---
G
-
G
K
I
D
G
F
V
S
G
I
G
T
G
G
T
I
T
G
A
G
K
Y
L
K
--
E
Q
--
N
-
A
N
V
K
L
Y
G
V
E
P
-
V
E
S
A
-
I
-----
L
-
S
---
G
G
------
K
----
P
G
P
H
K
I
Q
-
G
I
G
A
G
F
I
P
S
V
L
N
V
D
L
I
D
E
V
V
Q
V
S
S
D
E
S
I
D
M
A
R
Q
L
A
L
K
E
G
L
L
V
G
I
S
S
G
A
-
A
A
A
A
A
I
K
L
A
Q
R
P--
E
-
N
-
A
G
-
K
L
F
V
A
I
F
P
S
F
G
E
R
Y
L
S
---
T
---
V
L
F
----
26
PsiBlast_PDB
75.34
48%
-7
- C3 -
1Z7W
2
CYSK1_ARATH
A:
[4-308]
--
R
I
A
K
D
V
T
E
L
I
G
N
T
P
L
V
Y
L
N
N
V
-
A
---
E
G
C
-------
V
--
G
R
V
A
A
--
K
L
E
M
M
E
P
C
S
S
V
K
D
R
I
G
F
S
M
I
S
D
A
E
K
K
G
L
I
K
P
--
G
E
S
--
V
L
I
E
P
T
S
G
N
T
G
V
G
L
A
F
T
A
A
A
K
G
Y
K
L
I
I
T
M
P
A
S
M
S
T
E
R
R
I
I
L
L
A
F
G
V
E
L
V
L
T
D
P
A
K
G
M
---
K
G
A
---
I
A
K
A
E
E
I
L
A
K
T
-
P
-
N
G
Y
M
L
Q
-
Q
F
E
N
P
A
N
P
K
I
H
-
Y
E
T
T
G
P
E
I
W
K
G
T
---
G
-
G
K
I
D
G
F
V
S
G
I
G
T
G
G
T
I
T
G
A
G
K
Y
L
K
--
E
Q
--
N
-
A
N
V
K
L
Y
G
V
E
P
-
V
E
S
A
-
I
-----
L
-
S
---
G
G
------
K
----
P
G
P
H
K
I
Q
-
G
I
G
A
G
F
I
P
S
V
L
N
V
D
L
I
D
E
V
V
Q
V
S
S
D
E
S
I
D
M
A
R
Q
L
A
L
K
E
G
L
L
V
G
I
S
S
G
A
-
A
A
A
A
A
I
K
L
A
Q
R
P--
E
-
N
-
A
G
-
K
L
F
V
A
I
F
P
S
F
G
E
R
Y
L
S
---
T
---
V
L
F
----
22
PsiBlast_PDB
74.96
51%
18
- C3 -
2EFY
2
?
A:
[7-302]
-----------
I
G
K
T
P
V
V
R
L
A
K
V
-
V
---
E
P
D
-------
M
--
A
E
V
W
V
--
K
L
E
G
L
N
P
G
G
S
I
K
D
R
P
A
W
Y
M
I
K
D
A
E
E
R
G
I
L
R
P
--
G
-
S
G
Q
V
I
V
E
P
T
S
G
N
T
G
I
G
L
A
M
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
Q
M
S
E
E
R
K
R
V
L
K
A
F
G
A
E
L
V
L
T
D
P
E
R
R
M
---
L
A
A
---
R
E
E
A
L
R
L
K
E
E
L
---
G
A
F
M
P
D
-
Q
F
K
N
P
A
N
V
R
A
H
-
Y
E
T
T
G
P
E
L
Y
E
A
L
E
--
G
-
R
-
I
D
A
F
V
Y
G
S
G
T
G
G
T
I
T
G
V
G
R
Y
L
K
--
E
R
--
I
-
P
H
V
K
V
I
A
V
E
P
-
A
R
S
N
-
V
-----
L
-
S
---
G
G
------
K
----
M
G
Q
H
G
F
Q
-
G
M
G
P
G
F
I
P
E
N
L
D
L
S
L
L
D
G
V
I
Q
V
W
E
E
D
A
F
P
L
A
R
R
L
A
R
E
E
G
L
F
L
G
M
S
S
G
G
-
I
V
W
A
A
L
Q
V
A
R
E
---
L
-
G
-
P
G
-
K
R
V
A
C
I
S
P
D
G
G
W
K
Y
L
S
---
T
---
P
L
Y
A
---
121
HHSearch
74.72
43%
-14
- C3 -
3TBH
2
?
A:
[11-315]
---
V
A
Q
S
I
D
Q
L
I
G
Q
T
P
A
L
Y
L
N
K
L
-
N
---
N
-
T
-------
K
--
A
K
V
V
L
--
K
M
E
C
E
N
P
M
A
S
V
K
D
R
L
G
F
A
I
Y
D
K
A
E
K
E
G
K
L
I
P
--
G
K
S
--
I
V
V
E
S
S
S
G
N
T
G
V
S
L
A
H
L
G
A
I
R
G
Y
K
V
I
I
T
M
P
E
S
M
S
L
E
R
R
C
L
L
R
I
F
G
A
E
V
I
L
T
P
A
A
L
G
M
---
K
G
A
---
V
A
M
A
K
K
I
V
A
A
N
-
P
-
N
A
V
L
A
D
-
Q
F
A
T
K
Y
N
A
L
I
H
-
E
E
T
T
G
P
E
I
W
---
E
Q
T
N
-
H
N
V
D
C
F
I
A
G
V
G
T
G
G
T
L
T
G
V
A
R
A
L
K
--
K
M
--
G
-
S
H
A
R
I
V
A
V
E
P
-
T
E
S
P
-
V
-----
L
-
S
---
G
G
------
K
----
P
G
P
H
K
I
Q
-
G
I
G
P
G
F
V
P
D
V
L
D
R
S
L
I
D
E
V
L
C
V
A
G
D
D
A
I
E
T
A
L
K
L
T
R
S
D
G
V
F
C
G
F
S
G
G
A
-
N
V
Y
A
A
L
K
I
A
E
R
---
P
E
M
-
E
G
-
K
T
I
V
T
V
I
P
S
F
G
E
R
Y
L
S
---
T
---
T
L
Y
R
S
--
21
PsiBlast_PDB
73.84
51%
19
- C3 -
2ECQ
2
?
A:
[7-302]
-----------
I
G
K
T
P
V
V
R
L
A
K
V
-
V
---
E
P
D
-------
M
--
A
E
V
W
V
--
K
L
E
G
L
N
P
G
G
S
I
K
D
R
P
A
W
Y
M
I
K
D
A
E
E
R
G
I
L
R
P
--
G
-
S
G
Q
V
I
V
E
P
T
S
G
N
T
G
I
G
L
A
M
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
Q
M
S
E
E
R
K
R
V
L
K
A
F
G
A
E
L
V
L
T
D
P
E
R
R
M
---
L
A
A
---
R
E
E
A
L
R
L
K
E
E
L
---
G
A
F
M
P
D
-
Q
F
K
N
P
A
N
V
R
A
H
-
Y
E
T
T
G
P
E
L
Y
E
A
L
E
--
G
-
R
-
I
D
A
F
V
Y
G
S
G
T
G
G
T
I
T
G
V
G
R
Y
L
K
--
E
R
--
I
-
P
H
V
K
V
I
A
V
E
P
-
A
R
S
N
-
V
-----
L
-
S
---
G
G
------
K
----
M
G
Q
H
G
F
Q
-
G
M
G
P
G
F
I
P
E
N
L
D
L
S
L
L
D
G
V
I
Q
V
W
E
E
D
A
F
P
L
A
R
R
L
A
R
E
E
G
L
F
L
G
M
S
S
G
G
-
I
V
W
A
A
L
Q
V
A
R
E
---
L
-
G
-
P
G
-
K
R
V
A
C
I
S
P
D
G
G
W
K
Y
L
S
---
T
---
P
L
Y
A
---
35
PsiBlast_CBE
73.52
51%
18
- C3 -
2EFY
2
?
B:
[7-302]
-----------
I
G
K
T
P
V
V
R
L
A
K
V
-
V
---
E
P
D
-------
M
--
A
E
V
W
V
--
K
L
E
G
L
N
P
G
G
S
I
K
D
R
P
A
W
Y
M
I
K
D
A
E
E
R
G
I
L
R
P
--
G
-
S
GQ
V
I
V
E
P
T
S
G
N
T
G
I
G
L
A
M
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
Q
M
S
E
E
R
K
R
V
L
K
A
F
G
A
E
L
V
L
T
D
P
E
R
R
M
---
L
A
A
---
R
E
E
A
L
R
L
K
E
E
L
---
G
A
F
M
P
D
-
Q
F
K
N
P
A
N
V
R
A
H
-
Y
E
T
T
G
P
E
L
Y
E
A
L
E
--
G
-
R
-
I
D
A
F
V
Y
G
S
G
T
G
G
T
I
T
G
V
G
R
Y
L
K
--
E
R
--
I
-
P
H
V
K
V
I
A
V
E
P
-
A
R
S
N
-
V
-----
L
-
S
---
G
G
------
K
----
M
G
Q
H
G
F
Q
-
G
M
G
P
G
F
I
P
E
N
L
D
L
S
L
L
D
G
V
I
Q
V
W
E
E
D
A
F
P
L
A
R
R
L
A
R
E
E
G
L
F
L
G
M
S
S
G
G
-
I
V
W
A
A
L
Q
V
A
R
E
---
L
-
G
-
P
G
-
K
R
V
A
C
I
S
P
D
G
G
W
K
Y
L
S
---
T
---
P
L
Y
A
---
40
PsiBlast_CBE
73.43
45%
-50
- C3 -
2BHS
1
CYSM_ECOLI
B:
[8-292]
-----------
I
G
N
T
P
L
V
K
L
Q
R
M
-
G
---
P
D
N
-------
G
--
S
E
V
W
L
--
K
L
E
G
N
N
P
A
G
S
V
K
D
R
A
A
L
S
M
I
V
E
A
E
K
R
G
E
I
K
P
--
G
-
D
--
V
L
I
E
A
T
S
G
N
T
G
I
A
L
A
M
I
A
A
L
K
G
Y
R
M
K
L
L
M
P
D
N
M
S
Q
E
R
R
A
A
M
R
A
Y
G
A
E
L
I
L
V
T
K
E
Q
G
M
---
E
G
A
---
R
D
L
A
L
E
M
A
N
R
G
-
E
-
G
K
L
L
D
--
Q
F
N
N
P
D
N
P
Y
A
H
-
Y
T
T
T
G
P
E
I
---
W
Q
Q
T
G
-
G
R
I
T
H
F
V
S
S
M
G
T
T
G
T
I
T
G
V
S
R
F
M
R
--
E
Q
--
S
-
K
P
V
T
I
V
G
L
Q
P
E
E
G
S
S
-
I
------------------------
P
G
I
R
R
W
----
P
T
E
Y
L
P
G
I
F
N
A
S
L
V
D
E
V
L
D
I
H
Q
R
D
A
E
N
T
M
R
E
L
A
V
R
E
G
I
F
C
G
V
S
S
G
G
-
A
V
A
G
A
L
R
V
A
K
----
A
-
N
-
P
D
-
A
V
V
V
A
I
I
C
D
R
G
D
R
Y
L
S
---
T
---
G
V
F
----
1
Fugue
73.41
47%
1
- C3 -
1OAS
1
CYSK_SALTY
A:
[1-315]
-
S
K
I
Y
E
D
N
S
L
T
I
G
H
T
P
L
V
R
L
N
R
I
-------
G
-------
N
--
G
R
I
L
A
--
K
V
E
S
R
N
P
S
F
S
V
K
C
R
I
G
A
N
M
I
W
D
A
E
K
R
G
V
L
K
P
--
G
-
V
--
E
L
V
E
P
T
N
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
L
T
L
T
M
P
E
T
M
S
I
E
R
R
K
L
L
K
A
L
G
A
N
L
V
L
T
E
G
A
K
G
M
---
K
G
A
---
I
Q
K
A
E
E
I
V
A
S
D
-
P
-
Q
K
Y
L
L
L
Q
Q
F
S
N
P
A
N
P
E
I
H
-
E
K
T
T
G
P
E
I
W
E
D
T
---
D
-
G
Q
V
D
V
F
I
S
G
V
G
T
G
G
T
L
T
G
V
T
R
Y
I
K
--
G
T
KG
K
-
T
D
L
I
T
V
A
V
E
P
-
T
D
S
P
-
V
-----
I
-
A
---
Q
A
L
A
GE
E
I
K
----
P
G
P
H
K
I
Q
-
G
I
G
A
G
F
I
P
G
N
L
D
L
K
L
I
D
K
V
V
G
I
T
N
E
E
A
I
S
T
A
R
R
L
M
E
E
E
G
I
L
A
G
I
S
S
G
A
-
A
V
A
A
A
L
K
L
Q
E
D
---
E
-
S
F
T
N
-
K
N
I
V
V
I
L
P
S
S
G
E
R
Y
L
S
---
T
---
A
L
F
A
D
L
F
39
PsiBlast_CBE
73.38
45%
-49
- C3 -
2BHS
1
CYSM_ECOLI
C:
[8-292]
-----------
I
G
N
T
P
L
V
K
L
Q
R
M
-
G
---
P
D
N
-------
G
--
S
E
V
W
L
--
K
L
E
G
N
N
P
A
G
S
V
K
D
R
A
A
L
S
M
I
V
E
A
E
K
R
G
E
I
K
P
--
G
-
D
--
V
L
I
E
A
T
S
G
N
T
G
I
A
L
A
M
I
A
A
L
K
G
Y
R
M
K
L
L
M
P
D
N
M
S
Q
E
R
R
A
A
M
R
A
Y
G
A
E
L
I
L
V
T
K
E
Q
G
M
---
E
G
A
---
R
D
L
A
L
E
M
A
N
R
G
-
E
-
G
K
L
L
D
--
Q
F
N
N
P
D
N
P
Y
A
H
-
Y
T
T
T
G
P
E
I
---
W
Q
Q
T
G
-
G
R
I
T
H
F
V
S
S
M
G
T
T
G
T
I
T
G
V
S
R
F
M
R
--
E
Q
--
S
-
K
P
V
T
I
V
G
L
Q
P
E
E
G
S
S
-
I
------------------------
P
G
I
R
R
W
----
P
T
E
Y
L
P
G
I
F
N
A
S
L
V
D
E
V
L
D
I
H
Q
R
D
A
E
N
T
M
R
E
L
A
V
R
E
G
I
F
C
G
V
S
S
G
G
-
A
V
A
G
A
L
R
V
A
K
----
A
-
N
-
P
D
-
A
V
V
V
A
I
I
C
D
R
G
D
R
Y
L
S
---
T
---
G
V
F
----
102
PsiBlast_CBE
73.35
45%
4
- C3 -
1OAS
1
CYSK_SALTY
A:
[2-312]
--
K
I
Y
E
D
N
S
L
T
I
G
H
T
P
L
V
R
L
N
R
I
-------
G
-------
N
--
G
R
I
L
A
--
K
V
E
S
R
N
P
S
F
S
V
K
C
R
I
G
A
N
M
I
W
D
A
E
K
R
G
V
L
K
P
--
G
-
V
--
E
L
V
E
P
T
N
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
L
T
L
T
M
P
E
T
M
S
I
E
R
R
K
L
L
K
A
L
G
A
N
L
V
L
T
E
G
A
K
G
M
---
K
G
A
---
I
Q
K
A
E
E
I
V
A
S
D
-
P
-
Q
K
Y
L
L
L
Q
Q
F
S
N
P
A
N
P
E
I
H
-
E
K
T
T
G
P
E
I
W
---
E
D
T
D
-
G
Q
V
D
V
F
I
S
G
V
G
T
G
G
T
L
T
G
V
T
R
Y
I
K
GT
K
G
--
K
-
T
D
L
I
T
V
A
V
E
P
-
T
D
S
P
-
V
-----
I
-
A
---
Q
A
L
A
GE
E
I
K
----
P
G
P
H
K
I
Q
-
G
I
G
A
G
F
I
P
G
N
L
D
L
K
L
I
D
K
V
V
G
I
T
N
E
E
A
I
S
T
A
R
R
L
M
E
E
E
G
I
L
A
G
I
S
S
G
A
-
A
V
A
A
A
L
K
L
Q
E
D
---
E
-
S
F
T
N
-
K
N
I
V
V
I
L
P
S
S
G
E
R
Y
L
S
---
T
---
A
L
F
A
---
122
HHSearch
73.33
46%
-3
- C3 -
1Y7L
2
CYSK_HAEIN
A:
[2-311]
--
A
I
Y
A
D
N
S
Y
S
I
G
N
T
P
L
V
R
L
K
H
F
-
G
---
H
---------
N
--
G
N
V
V
V
--
K
I
E
G
R
N
P
S
Y
S
V
K
C
R
I
G
A
N
M
V
W
Q
A
E
K
D
G
T
L
T
K
--
G
-
K
--
E
I
V
D
A
T
S
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
I
T
L
T
M
P
E
T
M
S
L
E
R
K
R
L
L
C
G
L
G
V
N
L
V
L
T
E
G
A
K
G
M
---
K
G
A
---
I
A
K
A
E
E
I
V
A
S
D
P
S
-
R
Y
V
M
L
K
-
Q
F
E
N
P
A
N
P
Q
I
H
-
R
E
T
T
G
P
E
I
W
---
K
D
T
D
-
G
K
V
D
V
V
V
A
G
V
G
T
G
G
S
I
T
G
I
S
R
A
I
K
--
L
D
--
F
G
K
Q
I
T
S
V
A
V
E
P
-
V
E
S
P
-
V
-----
I
S
Q
T
L
A
G
E
------
E
V
K
--
P
G
P
H
K
I
Q
-
G
I
G
A
G
F
I
P
K
N
L
D
L
S
I
I
D
R
V
E
T
V
D
S
D
T
A
L
A
T
A
R
R
L
M
A
E
E
G
I
L
A
G
I
S
S
G
A
-
A
V
A
A
A
D
R
L
A
K
L
P--
E
-
F
-
A
D
-
K
L
I
V
V
I
L
P
S
A
S
E
R
Y
L
S
---
T
---
A
L
F
----
101
PsiBlast_CBE
73.32
45%
4
- C3 -
1OAS
1
CYSK_SALTY
B:
[2-312]
--
K
I
Y
E
D
N
S
L
T
I
G
H
T
P
L
V
R
L
N
R
I
-------
G
-------
N
--
G
R
I
L
A
--
K
V
E
S
R
N
P
S
F
S
V
K
C
R
I
G
A
N
M
I
W
D
A
E
K
R
G
V
L
K
P
--
G
-
V
--
E
L
V
E
P
T
N
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
L
T
L
T
M
P
E
T
M
S
I
E
R
R
K
L
L
K
A
L
G
A
N
L
V
L
T
E
G
A
K
G
M
---
K
G
A
---
I
Q
K
A
E
E
I
V
A
S
D
-
P
-
Q
K
Y
L
L
L
Q
Q
F
S
N
P
A
N
P
E
I
H
-
E
K
T
T
G
P
E
I
W
---
E
D
T
D
-
G
Q
V
D
V
F
I
S
G
V
G
T
G
G
T
L
T
G
V
T
R
Y
I
K
GT
K
G
--
K
-
T
D
L
I
T
V
A
V
E
P
-
T
D
S
P
-
V
-----
I
-
A
---
Q
A
LAGEEI
K
----
P
G
P
H
K
I
Q
-
G
I
G
A
G
F
I
P
G
N
L
D
L
K
L
I
D
K
V
V
G
I
T
N
E
E
A
I
S
T
A
R
R
L
M
E
E
E
G
I
L
A
G
I
S
S
G
A
-
A
V
A
A
A
L
K
L
Q
E
D
---
E
-
S
F
T
N
-
K
N
I
V
V
I
L
P
S
S
G
E
R
Y
L
S
---
T
---
A
L
F
A
---
41
PsiBlast_CBE
73.27
45%
-48
- C3 -
2BHS
1
CYSM_ECOLI
A:
[8-292]
-----------
I
G
N
T
P
L
V
K
L
Q
R
M
-
G
---
P
D
N
-------
G
--
S
E
V
W
L
--
K
L
E
G
N
N
P
A
G
S
V
K
D
R
A
A
L
S
M
I
V
E
A
E
K
R
G
E
I
K
P
--
G
-
D
--
V
L
I
E
A
T
S
G
N
T
G
I
A
L
A
M
I
A
A
L
K
G
Y
R
M
K
L
L
M
P
D
N
M
S
Q
E
R
R
A
A
M
R
A
Y
G
A
E
L
I
L
V
T
K
E
Q
G
M
---
E
G
A
---
R
D
L
A
L
E
M
A
N
R
G
-
E
-
G
K
L
L
D
--
Q
F
N
N
P
D
N
P
Y
A
H
-
Y
T
T
T
G
P
E
I
---
W
Q
Q
T
G
-
G
R
I
T
H
F
V
S
S
M
G
T
T
G
T
I
T
G
V
S
R
F
M
R
--
E
Q
--
S
-
K
P
V
T
I
V
G
L
Q
P
E
E
G
S
S
-
I
------------------------
P
G
I
R
R
W
----
P
T
E
Y
L
P
G
I
F
N
A
S
L
V
D
E
V
L
D
I
H
Q
R
D
A
E
N
T
M
R
E
L
A
V
R
E
G
I
F
C
G
V
S
S
G
G
-
A
V
A
G
A
L
R
V
A
K
----
A
-
N
-
P
D
-
A
V
V
V
A
I
I
C
D
R
G
D
R
Y
L
S
---
T
---
G
V
F
----
90
PsiBlast_CBE
73.22
44%
-50
- C3 -
2V03
3
CYSM_ECOLI
A:
[8-292]
-----------
I
G
N
T
P
L
V
K
L
Q
R
M
-
G
---
P
D
N
-------
G
--
S
E
V
W
L
--
K
L
E
G
N
N
P
A
G
S
V
K
D
R
A
A
L
S
M
I
V
E
A
E
K
R
G
E
I
K
P
--
G
-
D
--
V
L
I
E
A
T
S
G
N
T
G
I
A
L
A
M
I
A
A
L
K
G
Y
R
M
K
L
L
M
P
D
N
M
S
Q
E
R
R
A
A
M
R
A
Y
G
A
E
L
I
L
V
T
K
E
Q
G
M
---
E
G
A
---
R
D
L
A
L
E
M
A
N
R
G
-
E
-
G
K
L
L
D
--
Q
F
N
N
P
D
N
P
Y
A
H
-
Y
T
T
T
G
P
E
I
---
W
Q
Q
T
G
-
G
R
I
T
H
F
V
S
S
M
G
T
T
G
T
I
T
G
V
S
R
F
M
R
--
E
Q
--
S
-
K
P
V
T
I
V
G
L
Q
P
E
E
G
S
S
-
I
------------------------
P
G
I
R
R
W
----
P
T
E
Y
L
P
G
I
F
N
A
S
L
V
D
E
V
L
D
I
H
Q
R
D
A
E
N
T
M
R
E
L
A
V
R
E
G
I
F
C
G
V
S
S
G
G
-
A
V
A
G
A
L
R
V
A
A
----
A
-
N
-
P
D
-
A
V
V
V
A
I
I
C
D
R
G
D
R
Y
L
S
---
T
---
G
V
F
----
20
PsiBlast_PDB
73.06
51%
19
- C3 -
2ECO
2
?
A:
[7-302]
-----------
I
G
K
T
P
V
V
R
L
A
K
V
-
V
---
E
P
D
-------
M
--
A
E
V
W
V
--
K
L
E
G
L
N
P
G
G
S
I
K
D
R
P
A
W
Y
M
I
K
D
A
E
E
R
G
I
L
R
P
--
G
-
S
G
Q
V
I
V
E
P
T
S
G
N
T
G
I
G
L
A
M
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
Q
M
S
E
E
R
K
R
V
L
K
A
F
G
A
E
L
V
L
T
D
P
E
R
R
M
---
L
A
A
---
R
E
E
A
L
R
L
K
E
E
L
---
G
A
F
M
P
D
-
Q
F
K
N
P
A
N
V
R
A
H
-
Y
E
T
T
G
P
E
L
Y
E
A
L
E
--
G
-
R
-
I
D
A
F
V
Y
G
S
G
T
G
G
T
I
T
G
V
G
R
Y
L
K
--
E
R
--
I
-
P
H
V
K
V
I
A
V
E
P
-
A
R
S
N
-
V
-----
L
-
S
---
G
G
------
K
----
M
G
Q
H
G
F
Q
-
G
M
G
P
G
F
I
P
E
N
L
D
L
S
L
L
D
G
V
I
Q
V
W
E
E
D
A
F
P
L
A
R
R
L
A
R
E
E
G
L
F
L
G
M
S
S
G
G
-
I
V
W
A
A
L
Q
V
A
R
E
---
L
-
G
-
P
G
-
K
R
V
A
C
I
S
P
D
G
G
W
K
Y
L
S
---
T
---
P
L
Y
A
---
124
HHSearch
72.84
50%
20
- C3 -
1VE1
1
?
A:
[2-302]
------
R
V
E
G
A
I
G
K
T
P
V
V
R
L
A
K
V
-
V
---
E
P
D
-------
M
--
A
E
V
W
V
--
K
L
E
G
L
N
P
G
G
S
I
K
D
R
P
A
W
Y
M
I
K
D
A
E
E
R
G
I
L
R
P
GS
G
-
Q
--
V
I
V
E
P
T
S
G
N
T
G
I
G
L
A
M
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
Q
M
S
E
E
R
K
R
V
L
K
A
F
G
A
E
L
V
L
T
D
P
E
R
R
M
---
L
A
A
---
R
E
E
A
L
R
L
K
E
E
--
L
-
G
A
F
M
P
D
-
Q
F
K
N
P
A
N
V
R
A
H
-
Y
E
T
T
G
P
E
L
Y
---
E
A
L
E
-
G
R
I
D
A
F
V
Y
G
S
G
T
G
G
T
I
T
G
V
G
R
Y
L
K
--
E
R
--
I
-
P
H
V
K
V
I
A
V
E
P
-
A
R
S
N
-
V
-----
L
-
S
---
G
G
------
K
----
M
G
Q
H
G
F
Q
-
G
M
G
P
G
F
I
P
E
N
L
D
L
S
L
L
D
G
V
I
Q
V
W
E
E
D
A
F
P
L
A
R
R
L
A
R
E
E
G
L
F
L
G
M
S
S
G
G
I
V
W
A
A
L
Q
V
A
R
-
E
---
L
-
G
-
P
G
-
K
R
V
A
C
I
S
P
D
G
G
W
K
Y
L
S
---
T
---
P
L
Y
A
---
38
PsiBlast_CBE
72.62
45%
-49
- C3 -
2BHS
1
CYSM_ECOLI
D:
[8-292]
-----------
I
G
N
T
P
L
V
K
L
Q
R
M
-
G
---
P
D
N
-------
G
--
S
E
V
W
L
--
K
L
E
G
N
N
P
A
G
S
V
K
D
R
A
A
L
S
M
I
V
E
A
E
K
R
G
E
I
K
P
--
G
-
D
--
V
L
I
E
A
T
S
G
N
T
G
I
A
L
A
M
I
A
A
L
K
G
Y
R
M
K
L
L
M
P
D
N
M
S
Q
E
R
R
A
A
M
R
A
Y
G
A
E
L
I
L
V
T
K
E
Q
G
M
---
E
G
A
---
R
D
L
A
L
E
M
A
N
R
G
-
E
-
G
K
L
L
D
--
Q
F
N
N
P
D
N
P
Y
A
H
-
Y
T
T
T
G
P
E
I
---
W
Q
Q
T
G
-
G
R
I
T
H
F
V
S
S
M
G
T
T
G
T
I
T
G
V
S
R
F
M
R
--
E
Q
--
S
-
K
P
V
T
I
V
G
L
Q
P
E
E
G
S
S
-
I
------------------------
P
G
I
R
R
W
----
P
T
E
Y
L
P
G
I
F
N
A
S
L
V
D
E
V
L
D
I
H
Q
R
D
A
E
N
T
M
R
E
L
A
V
R
E
G
I
F
C
G
V
S
S
G
G
-
A
V
A
G
A
L
R
V
A
K
----
A
-
N
-
P
D
-
A
V
V
V
A
I
I
C
D
R
G
D
R
Y
L
S
---
T
---
G
V
F
----
19
PsiBlast_PDB
72.60
51%
19
- C3 -
1VE1
1
?
A:
[7-302]
-----------
I
G
K
T
P
V
V
R
L
A
K
V
-
V
---
E
P
D
-------
M
--
A
E
V
W
V
--
K
L
E
G
L
N
P
G
G
S
I
K
D
R
P
A
W
Y
M
I
K
D
A
E
E
R
G
I
L
R
P
--
G
-
S
G
Q
V
I
V
E
P
T
S
G
N
T
G
I
G
L
A
M
I
A
A
S
R
G
Y
R
L
I
L
T
M
P
A
Q
M
S
E
E
R
K
R
V
L
K
A
F
G
A
E
L
V
L
T
D
P
E
R
R
M
---
L
A
A
---
R
E
E
A
L
R
L
K
E
E
L
---
G
A
F
M
P
D
-
Q
F
K
N
P
A
N
V
R
A
H
-
Y
E
T
T
G
P
E
L
Y
E
A
L
E
--
G
-
R
-
I
D
A
F
V
Y
G
S
G
T
G
G
T
I
T
G
V
G
R
Y
L
K
--
E
R
--
I
-
P
H
V
K
V
I
A
V
E
P
-
A
R
S
N
-
V
-----
L
-
S
---
G
G
------
K
----
M
G
Q
H
G
F
Q
-
G
M
G
P
G
F
I
P
E
N
L
D
L
S
L
L
D
G
V
I
Q
V
W
E
E
D
A
F
P
L
A
R
R
L
A
R
E
E
G
L
F
L
G
M
S
S
G
G
-
I
V
W
A
A
L
Q
V
A
R
E
---
L
-
G
-
P
G
-
K
R
V
A
C
I
S
P
D
G
G
W
K
Y
L
S
---
T
---
P
L
Y
A
---
93
PsiBlast_CBE
71.90
43%
-2
- C3 -
3VBE
1
?
B:
[25-329]
---
I
K
K
H
V
S
Q
L
I
G
R
T
P
L
V
Y
L
N
K
V
-
T
---
E
G
C
-------
G
--
A
Y
V
A
V
--
K
Q
E
M
M
Q
P
T
A
S
I
K
D
R
P
A
Y
A
M
I
T
D
A
E
E
K
N
L
I
T
P
--
G
K
T
--
T
L
I
E
P
T
S
G
N
M
G
I
S
M
A
F
M
A
A
M
K
G
Y
K
M
V
L
T
M
P
S
Y
T
S
L
E
R
R
V
T
M
R
A
F
G
A
E
L
I
L
T
D
P
A
K
G
M
---
G
G
T
---
V
K
K
A
Y
E
L
L
E
N
T
-
P
-
N
A
H
M
L
Q
-
Q
F
S
N
P
A
N
T
Q
V
H
-
F
E
T
T
G
P
E
I
W
---
E
D
T
N
-
G
Q
V
D
I
F
V
M
G
I
G
S
G
G
T
V
S
G
V
G
Q
Y
L
K
--
S
K
--
N
-
P
N
V
K
I
Y
G
V
E
P
-
S
E
S
N
-
V
-----
L
-
N
---
G
G
------
K
----
P
G
P
H
H
I
T
-
G
N
G
V
G
F
K
P
D
I
L
D
L
D
V
M
E
K
V
L
E
V
S
S
E
D
A
V
N
M
A
R
V
L
A
L
K
E
G
L
M
V
G
I
S
S
G
A
-
N
T
V
A
A
L
R
L
A
Q
L
P--
E
-
N
-
K
G
-
K
L
I
V
T
V
H
P
S
F
G
E
R
Y
L
S
---
S
---
V
L
F
Q
---
94
PsiBlast_CBE
71.83
43%
-1
- C3 -
3VBE
1
?
A:
[25-329]
---
I
K
K
H
V
S
Q
L
I
G
R
T
P
L
V
Y
L
N
K
V
-
T
---
E
G
C
-------
G
--
A
Y
V
A
V
--
K
Q
E
M
M
Q
P
T
A
S
I
K
D
R
P
A
Y
A
M
I
T
D
A
E
E
K
N
L
I
T
P
--
G
K
T
--
T
L
I
E
P
T
S
G
N
M
G
I
S
M
A
F
M
A
A
M
K
G
Y
K
M
V
L
T
M
P
S
Y
T
S
L
E
R
R
V
T
M
R
A
F
G
A
E
L
I
L
T
D
P
A
K
G
M
---
G
G
T
---
V
K
K
A
Y
E
L
L
E
N
T
-
P
-
N
A
H
M
L
Q
-
Q
F
S
N
P
A
N
T
Q
V
H
-
F
E
T
T
G
P
E
I
W
---
E
D
T
N
-
G
Q
V
D
I
F
V
M
G
I
G
S
G
G
T
V
S
G
V
G
Q
Y
L
K
--
S
K
--
N
-
P
N
V
K
I
Y
G
V
E
P
-
S
E
S
N
-
V
-----
L
-
N
---
G
G
------
K
----
P
G
P
H
H
I
T
-
G
N
G
V
G
F
K
P
D
I
L
D
L
D
V
M
E
K
V
L
E
V
S
S
E
D
A
V
N
M
A
R
V
L
A
L
K
E
G
L
M
V
G
I
S
S
G
A
-
N
T
V
A
A
L
R
L
A
Q
L
P--
E
-
N
-
K
G
-
K
L
I
V
T
V
H
P
S
F
G
E
R
Y
L
S
---
S
---
V
L
F
Q
---
123
HHSearch
71.71
48%
30
- C3 -
4LMB
3
?
A:
[8-317]
-
M
L
I
A
R
D
I
T
Q
L
V
G
R
T
P
L
V
Q
L
N
R
I
-
P
---
V
A
E
-------
G
VK
A
R
I
V
V
--
K
L
E
S
M
N
P
A
A
S
V
K
D
R
I
G
V
S
M
V
E
D
A
E
A
A
G
L
I
H
P
--
D
K
T
--
I
L
V
E
P
T
S
G
N
T
G
I
A
L
A
M
V
A
A
A
K
G
Y
R
L
V
L
T
M
P
E
T
M
S
L
E
R
R
A
M
L
K
A
Y
G
A
Q
L
E
L
T
P
G
S
Q
G
M
---
E
G
A
---
I
T
R
A
E
E
I
V
E
N
T
-
P
-
N
A
Y
S
L
Q
-
Q
F
R
N
P
A
N
P
K
I
H
-
R
E
T
T
A
E
E
I
W
---
A
D
T
D
-
G
L
V
D
I
V
I
G
G
V
G
T
G
G
T
I
T
G
I
A
E
T
I
K
--
P
R
--
R
-
P
Q
F
Q
A
I
A
V
E
P
-
S
N
S
P
-
V
-----
L
-
S
---
G
G
------
Q
----
P
G
P
H
K
I
Q
-
G
I
G
A
G
F
I
P
A
I
F
R
P
E
L
I
D
E
V
I
I
V
D
D
T
E
A
F
A
Y
A
R
R
L
A
R
Q
E
G
L
L
S
G
I
S
A
G
A
-
A
L
W
A
A
I
Q
V
G
K
R
P--
E
-
N
-
E
D
-
K
L
I
V
M
I
Q
P
S
F
G
E
R
Y
L
S
---
T
---
A
L
F
K
D
--
91
PsiBlast_CBE
71.32
43%
-1
- C3 -
3VBE
1
?
D:
[25-329]
---
I
K
K
H
V
S
Q
L
I
G
R
T
P
L
V
Y
L
N
K
V
-
T
---
E
G
C
-------
G
--
A
Y
V
A
V
--
K
Q
E
M
M
Q
P
T
A
S
I
K
D
R
P
A
Y
A
M
I
T
D
A
E
E
K
N
L
I
T
P
--
G
K
T
--
T
L
I
E
P
T
S
G
N
M
G
I
S
M
A
F
M
A
A
M
K
G
Y
K
M
V
L
T
M
P
S
Y
T
S
L
E
R
R
V
T
M
R
A
F
G
A
E
L
I
L
T
D
P
A
K
G
M
---
G
G
T
---
V
K
K
A
Y
E
L
L
E
N
T
-
P
-
N
A
H
M
L
Q
-
Q
F
S
N
P
A
N
T
Q
V
H
-
F
E
T
T
G
P
E
I
W
---
E
D
T
N
-
G
Q
V
D
I
F
V
M
G
I
G
S
G
G
T
V
S
G
V
G
Q
Y
L
K
--
S
K
--
N
-
P
N
V
K
I
Y
G
V
E
P
-
S
E
S
N
-
V
-----
L
-
N
---
G
G
------
K
----
P
G
P
H
H
I
T
-
G
N
G
V
G
F
K
P
D
I
L
D
L
D
V
M
E
K
V
L
E
V
S
S
E
D
A
V
N
M
A
R
V
L
A
L
K
E
G
L
M
V
G
I
S
S
G
A
-
N
T
V
A
A
L
R
L
A
Q
L
P--
E
-
N
-
K
G
-
K
L
I
V
T
V
H
P
S
F
G
E
R
Y
L
S
---
S
---
V
L
F
Q
---
106
PsiBlast_CBE
71.31
45%
6
- C3 -
1FCJ
4
CYSK_SALTY
A:
[2-302]
--
K
I
Y
E
D
N
S
L
T
I
G
H
T
P
L
V
R
L
N
R
I
-------
G
-------
N
--
G
R
I
L
A
--
K
V
E
S
R
N
P
S
F
S
V
K
C
R
I
G
A
N
M
I
W
D
A
E
K
R
G
V
L
K
P
--
G
-
V
--
E
L
V
E
P
T
N
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
L
T
L
T
M
P
E
T
M
S
I
E
R
R
K
L
L
K
A
L
G
A
N
L
V
L
T
E
G
A
K
G
M
---
K
G
A
---
I
Q
K
A
E
E
I
V
A
S
D
-
P
-
Q
K
Y
L
L
L
Q
Q
F
S
N
P
A
N
P
E
I
H
-
E
K
T
T
G
P
E
I
W
---
E
D
T
D
-
G
Q
V
D
V
F
I
S
G
V
G
T
G
G
T
L
T
G
V
T
R
Y
I
K
GT
K
G
--
K
-
T
D
L
I
T
V
A
V
E
P
-
T
D
S
P
-
V
-----
I
-
A
---
Q
A
L
A
GEE
I
K
----
P
G
P
H
K
I
Q
-
G
I
G
A
G
F
I
P
G
N
L
D
L
K
L
I
D
K
V
V
G
I
T
N
E
E
A
I
S
T
A
R
R
L
M
E
E
E
G
I
L
A
G
I
S
S
G
A
-
A
V
A
A
A
L
K
L
Q
E
D
---
E
-
S
F
T
N
-
K
N
I
V
V
I
L
P
S
S
G
-------------------
105
PsiBlast_CBE
71.16
45%
10
- C3 -
1FCJ
4
CYSK_SALTY
B:
[2-304]
--
K
I
Y
E
D
N
S
L
T
I
G
H
T
P
L
V
R
L
N
R
I
-------
G
-------
N
--
G
R
I
L
A
--
K
V
E
S
R
N
P
S
F
S
V
K
C
R
I
G
A
N
M
I
W
D
A
E
K
R
G
V
L
K
P
--
G
-
V
--
E
L
V
E
P
T
N
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
L
T
L
T
M
P
E
T
M
S
I
E
R
R
K
L
L
K
A
L
G
A
N
L
V
L
T
E
G
A
K
G
M
---
K
G
A
---
I
Q
K
A
E
E
I
V
A
S
D
-
P
-
Q
K
Y
L
L
L
Q
Q
F
S
N
P
A
N
P
E
I
H
-
E
K
T
T
G
P
E
I
W
---
E
D
T
D
-
G
Q
V
D
V
F
I
S
G
V
G
T
G
G
T
L
T
G
V
T
R
Y
I
K
GT
K
G
--
K
-
T
D
L
I
T
V
A
V
E
P
-
T
D
S
P
-
V
-----
I
-
A
---
Q
A
LAGEEI
K
----
P
G
P
H
K
I
Q
-
G
I
G
A
G
F
I
P
G
N
L
D
L
K
L
I
D
K
V
V
G
I
T
N
E
E
A
I
S
T
A
R
R
L
M
E
E
E
G
I
L
A
G
I
S
S
G
A
-
A
V
A
A
A
L
K
L
Q
E
D
---
E
-
S
F
T
N
-
K
N
I
V
V
I
L
P
S
S
G
E
R
-----------------
103
PsiBlast_CBE
71.06
45%
4
- C3 -
1FCJ
4
CYSK_SALTY
D:
[2-302]
--
K
I
Y
E
D
N
S
L
T
I
G
H
T
P
L
V
R
L
N
R
I
-------
G
-------
N
--
G
R
I
L
A
--
K
V
E
S
R
N
P
S
F
S
V
K
C
R
I
G
A
N
M
I
W
D
A
E
K
R
G
V
L
K
P
--
G
-
V
--
E
L
V
E
P
T
N
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
L
T
L
T
M
P
E
T
M
S
I
E
R
R
K
L
L
K
A
L
G
A
N
L
V
L
T
E
G
A
K
G
M
---
K
G
A
---
I
Q
K
A
E
E
I
V
A
S
D
-
P
-
Q
K
Y
L
L
L
Q
Q
F
S
N
P
A
N
P
E
I
H
-
E
K
T
T
G
P
E
I
W
---
E
D
T
D
-
G
Q
V
D
V
F
I
S
G
V
G
T
G
G
T
L
T
G
V
T
R
Y
I
K
GT
K
G
--
K
-
T
D
L
I
T
V
A
V
E
P
-
T
D
S
P
-
V
-----
I
-
A
---
Q
A
LAGEEI
K
----
P
G
P
H
K
I
Q
-
G
I
G
A
G
F
I
P
G
N
L
D
L
K
L
I
D
K
V
V
G
I
T
N
E
E
A
I
S
T
A
R
R
L
M
E
E
E
G
I
L
A
G
I
S
S
G
A
-
A
V
A
A
A
L
K
L
Q
E
D
---
E
-
S
F
T
N
-
K
N
I
V
V
I
L
P
S
S
G
-------------------
23
PsiBlast_PDB
70.81
49%
26
- C3 -
4LMA
3
?
A:
[8-318]
-
M
R
I
A
H
D
V
T
E
L
V
G
R
T
P
L
V
Q
L
N
R
I
P
Q
---
A
E
G
-------
C
L-
G
R
I
V
M
--
K
L
E
G
M
N
P
A
A
S
V
K
D
R
I
G
T
H
M
I
N
S
A
E
K
A
G
L
I
N
P
E-
T
-
T
--
V
L
V
E
P
T
S
G
N
T
G
I
A
L
A
M
T
A
A
A
K
G
Y
R
L
I
L
T
M
P
E
T
M
S
L
E
R
R
A
M
L
K
A
Y
G
A
T
L
E
L
T
P
G
S
Q
G
M
---
K
G
A
---
I
L
R
A
Q
Q
I
V
D
S
I
-
P
-
G
A
Y
M
L
Q
-
Q
F
R
N
P
S
N
P
E
I
H
-
R
L
T
T
A
E
E
I
W
Q
D
T
E
----
G
Q
V
D
F
I
V
A
G
V
G
T
G
G
T
I
T
G
V
A
E
V
I
K
--
S
R
--
K
-
P
S
F
Q
V
V
A
V
E
P
-
F
N
S
P
-
V
-----
I
-
S
---
G
G
------
N
----
P
G
P
H
K
I
Q
-
G
I
G
A
G
F
I
P
E
V
L
R
T
D
L
I
D
E
V
I
T
V
S
D
E
E
A
F
Q
F
G
R
R
L
A
K
E
E
G
L
L
S
G
I
S
S
G
A
-
N
L
C
A
A
I
Q
L
A
Q
R
---
P
-
E
-
N
E
G
K
L
I
V
V
I
Q
P
S
F
G
E
R
Y
L
S
---
T
---
L
M
F
Q
N
I
-
36
PsiBlast_CBE
70.73
49%
22
- C3 -
4LMA
2
?
B:
[8-318]
-
M
R
I
A
H
D
V
T
E
L
V
G
R
T
P
L
V
Q
L
N
R
I
P
Q
---
A
E
G
-------
C
L-
G
R
I
V
M
--
K
L
E
G
M
N
P
A
A
S
V
K
D
R
I
G
T
H
M
I
N
S
A
E
K
A
G
L
I
N
P
E-
T
-
T
--
V
L
V
E
P
T
S
G
N
T
G
I
A
L
A
M
T
A
A
A
K
G
Y
R
L
I
L
T
M
P
E
T
M
S
L
E
R
R
A
M
L
K
A
Y
G
A
T
L
E
L
T
P
G
S
Q
G
M
---
K
G
A
---
I
L
R
A
Q
Q
I
V
D
S
I
-
P
-
G
A
Y
M
L
Q
-
Q
F
R
N
P
S
N
P
E
I
H
-
R
L
T
T
A
E
E
I
W
Q
D
T
E
----
G
Q
V
D
F
I
V
A
G
V
G
T
G
G
T
I
T
G
V
A
E
V
I
K
--
S
R
--
K
-
P
S
F
Q
V
V
A
V
E
P
-
F
N
S
P
-
V
-----
I
-
S
---
G
G
------
N
----
P
G
P
H
K
I
Q
-
G
I
G
A
G
F
I
P
E
V
L
R
T
D
L
I
D
E
V
I
T
V
S
D
E
E
A
F
Q
F
G
R
R
L
A
K
E
E
G
L
L
S
G
I
S
S
G
A
-
N
L
C
A
A
I
Q
L
A
Q
R
---
P
-
E
-
N
E
G
K
L
I
V
V
I
Q
P
S
F
G
E
R
Y
L
S
---
T
---
L
M
F
Q
N
I
-
104
PsiBlast_CBE
70.55
45%
10
- C3 -
1FCJ
4
CYSK_SALTY
C:
[2-304]
--
K
I
Y
E
D
N
S
L
T
I
G
H
T
P
L
V
R
L
N
R
I
-------
G
-------
N
--
G
R
I
L
A
--
K
V
E
S
R
N
P
S
F
S
V
K
C
R
I
G
A
N
M
I
W
D
A
E
K
R
G
V
L
K
P
--
G
-
V
--
E
L
V
E
P
T
N
G
N
T
G
I
A
L
A
Y
V
A
A
A
R
G
Y
K
L
T
L
T
M
P
E
T
M
S
I
E
R
R
K
L
L
K
A
L
G
A
N
L
V
L
T
E
G
A
K
G
M
---
K
G
A
---
I
Q
K
A
E
E
I
V
A
S
D
-
P
-
Q
K
Y
L
L
L
Q
Q
F
S
N
P
A
N
P
E
I
H
-
E
K
T
T
G
P
E
I
W
---
E
D
T
D
-
G
Q
V
D
V
F
I
S
G
V
G
T
G
G
T
L
T
G
V
T
R
Y
I
K
GT
K
G
--
K
-
T
D
L
I
T
V
A
V
E
P
-
T
D
S
P
-
V
-----
I
-
A
---
Q
A
LAGEEI
K
----
P
G
P
H
K
I
Q
-
G
I
G
A
G
F
I
P
G
N
L
D
L
K
L
I
D
K
V
V
G
I
T
N
E
E
A
I
S
T
A
R
R
L
M
E
E
E
G
I
L
A
G
I
S
S
G
A
-
A
V
A
A
A
L
K
L
Q
E
D
---
E
-
S
F
T
N
-
K
N
I
V
V
I
L
P
S
S
G
E
R
-----------------
24
PsiBlast_PDB
70.37
47%
25
- C3 -
4LMB
3
?
A:
[10-315]
---
I
A
R
D
I
T
Q
L
V
G
R
T
P
L
V
Q
L
N
R
I
-
P
---
V
A
E
-------
G
VK
A
R
I
V
V
--
K
L
E
S
M
N
P
A
A
S
V
K
D
R
I
G
V
S
M
V
E
D
A
E
A
A
G
L
I
H
P
--
D
K
T
--
I
L
V
E
P
T
S
G
N
T
G
I
A
L
A
M
V
A
A
A
K
G
Y
R
L
V
L
T
M
P
E
T
M
S
L
E
R
R
A
M
L
K
A
Y
G
A
Q
L
E
L
T
P
G
S
Q
G
M
---
E
G
A
---
I
T
R
A
E
E
I
V
E
N
T
-
P
-
N
A
Y
S
L
Q
-
Q
F
R
N
P
A
N
P
K
I
H
-
R
E
T
T
A
E
E
I
W
A
D
T
D
G
L
----
V
D
I
V
I
G
G
V
G
T
G
G
T
I
T
G
I
A
E
T
I
K
--
P
R
--
R
-
P
Q
F
Q
A
I
A
V
E
P
-
S
N
S
P
-
V
-----
L
-
S
---
G
G
------
Q
----
P
G
P
H
K
I
Q
-
G
I
G
A
G
F
I
P
A
I
F
R
P
E
L
I
D
E
V
I
I
V
D
D
T
E
A
F
A
Y
A
R
R
L
A
R
Q
E
G
L
L
S
G
I
S
A
G
A
-
A
L
W
A
A
I
Q
V
G
K
R
P--
E
-
N
-
E
D
-
K
L
I
V
M
I
Q
P
S
F
G
E
R
Y
L
S
---
T
---
A
L
F
----
45
PsiBlast_CBE
70.09
41%
22
- C3 -
4L0D
2
CBS_HUMAN
B:
[75-393]
--
K
I
L
P
D
I
L
K
K
I
G
D
T
P
M
V
R
I
N
K
I
-
G
---
K
K
F
-------
G
--
L
K
C
E
L
L
A
K
C
E
F
F
N
A
G
G
S
V
K
D
R
I
S
L
R
M
I
E
D
A
E
R
D
G
T
L
K
P
--
G
-
D
--
T
I
I
E
P
T
S
G
N
T
G
I
G
L
A
L
A
A
A
V
R
G
Y
R
C
I
I
V
M
P
E
K
M
S
S
E
K
V
D
V
L
R
A
L
G
A
E
I
V
R
T
P
T
N
A
R
F
DSP
E
S
H
---
V
G
V
A
W
R
L
K
N
E
I
-
P
-
N
S
H
I
L
D
-
Q
Y
R
N
A
S
N
P
L
A
H
-
Y
D
T
T
A
D
E
I
---
L
Q
Q
C
D
-
G
K
L
D
M
L
V
A
S
V
G
T
G
G
T
I
T
G
I
A
R
K
L
K
--
E
K
--
C
-
P
G
C
R
I
I
G
V
D
P
-
E
G
S
I
-
L
AEPEE
L
-
N
---
Q
T
------
E
----
Q
T
T
Y
E
V
E
-
G
I
G
Y
D
F
I
P
T
V
L
D
R
T
V
V
D
K
W
F
K
S
N
D
E
E
A
F
T
F
A
R
M
L
I
A
Q
E
G
L
L
C
G
G
S
A
G
S
-
T
V
A
V
A
V
K
A
A
Q
E
---
L
-
Q
-
E
G
-
Q
R
C
V
V
I
L
P
D
S
V
R
N
Y
M
T
KFL
S
---
D
R
W
----
46
PsiBlast_CBE
70.07
41%
25
- C3 -
4L0D
2
CBS_HUMAN
A:
[75-394]
--
K
I
L
P
D
I
L
K
K
I
G
D
T
P
M
V
R
I
N
K
I
-
G
---
K
K
F
-------
G
--
L
K
C
E
L
L
A
K
C
E
F
F
N
A
G
G
S
V
K
D
R
I
S
L
R
M
I
E
D
A
E
R
D
G
T
L
K
P
--
G
-
D
--
T
I
I
E
P
T
S
G
N
T
G
I
G
L
A
L
A
A
A
V
R
G
Y
R
C
I
I
V
M
P
E
K
M
S
S
E
K
V
D
V
L
R
A
L
G
A
E
I
V
R
T
P
T
N
A
R
F
DSP
E
S
H
---
V
G
V
A
W
R
L
K
N
E
I
-
P
-
N
S
H
I
L
D
-
Q
Y
R
N
A
S
N
P
L
A
H
-
Y
D
T
T
A
D
E
I
---
L
Q
Q
C
D
-
G
K
L
D
M
L
V
A
S
V
G
T
G
G
T
I
T
G
I
A
R
K
L
K
--
E
K
--
C
-
P
G
C
R
I
I
G
V
D
P
-
E
G
S
I
-
L
AEPEE
L
-
N
---
Q
T
------
E
----
Q
T
T
Y
E
V
E
-
G
I
G
Y
D
F
I
P
T
V
L
D
R
T
V
V
D
K
W
F
K
S
N
D
E
E
A
F
T
F
A
R
M
L
I
A
Q
E
G
L
L
C
G
G
S
A
G
S
-
T
V
A
V
A
V
K
A
A
Q
E
---
L
-
Q
-
E
G
-
Q
R
C
V
V
I
L
P
D
S
V
R
N
Y
M
T
KFL
S
---
D
R
W
----
43
PsiBlast_CBE
69.45
42%
26
- C3 -
4PCU
2
CBS_HUMAN
B:
[75-396]
--
K
I
L
P
D
I
L
K
K
I
G
D
T
P
M
V
R
I
N
K
I
-
G
---
K
K
F
-------
G
--
L
K
C
E
L
L
A
K
C
E
F
F
N
A
G
G
S
V
K
D
R
I
S
L
R
M
I
E
D
A
E
R
D
G
T
L
K
P
--
G
-
D
--
T
I
I
E
P
T
S
G
N
T
G
I
G
L
A
L
A
A
A
V
R
G
Y
R
C
I
I
V
M
P
E
K
M
S
S
E
K
V
D
V
L
R
A
L
G
A
E
I
V
R
T
P
T
N
A
R
F
DS-
P
S
S
H--
V
G
V
A
W
R
L
K
N
E
I
-
P
-
N
S
H
I
L
D
-
Q
Y
R
N
A
S
N
P
L
A
H
-
Y
D
T
T
A
D
E
I
---
L
Q
Q
C
D
-
G
K
L
D
M
L
V
A
S
V
G
T
G
G
T
I
T
G
I
A
R
K
L
K
--
E
K
--
C
-
P
G
C
R
I
I
G
V
D
P
-
E
G
S
I
-
L
AEPEE
L
-
N
---
Q
T
------
E
----
Q
T
T
Y
E
V
E
-
G
I
G
Y
D
F
I
P
T
V
L
D
R
T
V
V
D
K
W
F
K
S
N
D
E
E
A
F
T
F
A
R
M
L
I
A
Q
E
G
L
L
C
G
G
S
A
G
S
-
T
V
A
V
A
V
K
A
A
Q
E
---
L
-
Q
-
E
G
-
Q
R
C
V
V
I
L
P
D
S
V
R
N
Y
M
T
KFL
S
---
D
R
W
----
59
PsiBlast_CBE
69.00
41%
31
- C3 -
4COO
9
CBS_HUMAN
A:
[97-415]
--
K
I
L
P
D
I
L
K
K
I
G
D
T
P
M
V
R
I
N
K
I
-
G
---
K
K
F
-------
G
--
L
K
C
E
L
L
A
K
C
E
F
F
N
A
G
G
S
V
K
D
R
I
S
L
R
M
I
E
D
A
E
R
D
G
T
L
K
P
--
G
-
D
--
T
I
I
E
P
T
S
G
N
T
G
I
G
L
A
L
A
A
A
V
R
G
Y
R
C
I
I
V
M
P
E
K
M
S
S
E
K
V
D
V
L
R
A
L
G
A
E
I
V
R
T
P
T
N
A
R
F
DSP
E
S
H
---
V
G
V
A
W
R
L
K
N
E
I
-
P
-
N
S
H
I
L
D
-
Q
Y
R
N
A
S
N
P
L
A
H
-
Y
D
T
T
A
D
E
I
---
L
Q
Q
C
D
-
G
K
L
D
M
L
V
A
S
V
G
T
G
G
T
I
T
G
I
A
R
K
L
K
--
E
K
--
C
-
P
G
C
R
I
I
G
V
D
P
-
E
G
S
I
-
L
AEPEE
L
-
N
---
Q
T
------
E
----
Q
T
T
Y
E
V
E
-
G
I
G
Y
D
F
I
P
T
V
L
D
R
T
V
V
D
K
W
F
K
S
N
D
E
E
A
F
T
F
A
R
M
L
I
A
Q
E
G
L
L
C
G
G
S
A
G
S
-
T
V
A
V
A
V
K
A
A
Q
E
---
L
-
Q
-
E
G
-
Q
R
C
V
V
I
L
P
D
S
V
R
N
Y
M
T
KFL
S
---
D
R
W
----
129
HHSearch
68.77
41%
25
- C3 -
3PC3
2
?
A:
[51-363]
----
T
P
N
I
L
E
V
I
G
C
T
P
L
V
K
L
N
N
I
-
P
---
A
S
D
GI-----
E
--
C
E
M
Y
A
--
K
C
E
F
L
N
P
G
G
S
V
K
D
R
I
G
Y
R
M
V
Q
D
A
E
E
Q
G
L
L
K
P
--
G
-
Y
--
T
I
I
E
P
T
S
G
N
T
G
I
G
L
A
M
A
C
A
V
K
G
Y
K
C
I
I
V
M
P
E
K
M
S
N
E
K
V
S
A
L
R
T
L
G
A
K
I
I
R
T
P
T
E
A
A
Y
---
D
S
P
EG
L
I
Y
V
A
Q
Q
L
Q
R
E
T
-
P
-
N
S
I
V
L
D
-
Q
Y
R
N
A
G
N
P
L
A
H
-
Y
D
G
T
A
A
E
I
L
---
W
Q
L
D
-
N
K
V
D
M
I
V
V
S
A
G
T
A
G
T
I
S
G
I
G
R
K
I
K
--
E
Q
--
V
-
P
S
C
Q
I
V
G
V
D
P
-
Y
G
S
I
-
L
-----
A
-
R
---
P
A
------
E
LNKT
D
V
Q
F
Y
E
V
E
G
I
G
Y
D
F
P
P
T
V
F
D
D
T
V
V
D
V
W
T
K
I
G
D
S
D
C
F
P
M
S
R
R
L
N
A
E
E
G
L
L
C
G
G
S
S
G
G
-
A
M
H
A
A
L
E
H
A
R
K
---
L
-
K
-
K
G
-
Q
R
C
V
V
I
L
P
D
G
I
R
N
Y
M
T
---
K
---
F
V
S
D
N
--
44
PsiBlast_CBE
68.28
42%
24
- C3 -
4PCU
2
CBS_HUMAN
A:
[75-395]
--
K
I
L
P
D
I
L
K
K
I
G
D
T
P
M
V
R
I
N
K
I
-
G
---
K
K
F
-------
G
--
L
K
C
E
L
L
A
K
C
E
F
F
N
A
G
G
S
V
K
D
R
I
S
L
R
M
I
E
D
A
E
R
D
G
T
L
K
P
--
G
-
D
--
T
I
I
E
P
T
S
G
N
T
G
I
G
L
A
L
A
A
A
V
R
G
Y
R
C
I
I
V
M
P
E
K
M
S
S
E
K
V
D
V
L
R
A
L
G
A
E
I
V
R
T
P
--
A
R
F
DS-
P
S
S
H--
V
G
V
A
W
R
L
K
N
E
I
-
P
-
N
S
H
I
L
D
-
Q
Y
R
N
A
S
N
P
L
A
H
-
Y
D
T
T
A
D
E
I
---
L
Q
Q
C
D
-
G
K
L
D
M
L
V
A
S
V
G
T
G
G
T
I
T
G
I
A
R
K
L
K
--
E
K
--
C
-
P
G
C
R
I
I
G
V
D
P
-
E
G
S
I
-
L
AEPEE
L
-
N
---
Q
T
------
E
----
Q
T
T
Y
E
V
E
-
G
I
G
Y
D
F
I
P
T
V
L
D
R
T
V
V
D
K
W
F
K
S
N
D
E
E
A
F
T
F
A
R
M
L
I
A
Q
E
G
L
L
C
G
G
S
A
G
S
-
T
V
A
V
A
V
K
A
A
Q
E
---
L
-
Q
-
E
G
-
Q
R
C
V
V
I
L
P
D
S
V
R
N
Y
M
T
KFL
S
---
D
R
W
----
125
HHSearch
67.93
41%
20
- C3 -
2PQM
2
?
A:
[12-320]
--
R
I
Y
H
N
I
L
E
T
I
G
G
T
P
L
V
E
L
H
G
V
-
T
---
E
H
P
RIKK---
G
--
T
R
I
L
V
--
K
L
E
Y
F
N
P
M
S
S
V
K
D
R
V
G
F
N
I
V
Y
Q
A
I
K
D
G
R
L
K
P
--
G
-
M
--
E
I
I
E
S
T
S
G
N
T
G
I
A
L
C
Q
A
G
A
V
F
G
Y
R
V
N
I
A
M
P
S
T
M
S
V
E
R
Q
M
I
M
K
A
F
G
A
E
L
I
L
T
E
G
K
K
G
M
---
P
G
A
---
I
E
E
V
N
K
M
I
K
E
N
-
P
G
K
Y
F
V
A
N
-
Q
F
G
N
P
D
N
T
-
A
A
-
H
H
Y
T
A
N
E
I
W
---
E
D
T
D
-
G
E
V
D
I
V
V
S
A
V
G
T
S
G
T
V
I
G
V
A
E
K
L
K
--
E
K
--
K
-
K
G
I
K
I
I
A
V
E
P
-
E
E
S
A
-
V
-----
L
-
E
---
G
K
------
A
----
K
G
P
H
G
I
Q
-
G
I
G
A
G
F
I
P
D
I
Y
K
K
E
F
V
D
E
I
I
P
I
K
T
Q
D
A
W
K
M
A
R
A
V
V
K
Y
D
G
I
M
C
G
M
S
S
G
A
-
A
I
L
A
G
L
K
E
A
E
K
P--
E
-
N
-
E
G
-
K
T
I
V
I
I
V
P
S
C
G
E
R
Y
L
S
---
T
---
D
L
Y
K
---
42
PsiBlast_CBE
67.43
43%
34
- C3 -
5HBG
1
CYSM_HELPY
B:
[1-305]
-
M
M
I
I
T
T
M
Q
D
A
I
G
R
T
P
V
F
K
F
T
N
K
-
D
YPI
P
L
N
-------
S
--
A
-
I
Y
A
--
K
L
E
H
L
N
P
G
G
S
V
K
D
R
L
G
Q
Y
L
I
G
E
G
F
K
T
G
K
I
T
S
--
K
-
T
--
T
I
I
E
P
T
A
G
N
T
G
I
A
L
A
L
V
A
I
K
H
H
L
K
T
I
F
V
V
P
E
K
F
S
T
E
K
Q
Q
I
M
R
A
L
G
A
L
V
I
N
T
P
T
S
E
G
I
---
S
G
A
---
I
K
K
S
K
E
L
A
E
S
I
-
P
-
D
S
Y
L
P
L
-
Q
F
E
N
P
D
N
P
A
A
Y
-
Y
H
T
L
A
P
E
I
---
V
Q
E
L
G
-
T
N
L
T
S
F
V
A
G
I
G
S
G
G
T
F
A
G
T
A
R
Y
L
K
--
E
R
--
I
-
P
A
I
R
L
I
G
V
E
P
-
E
G
S
--
I
-----
L
-
N
---
G
G
------
E
----
P
G
P
H
E
I
E
-
G
I
G
V
E
F
I
P
P
F
F
E
N
L
D
I
D
G
F
E
T
I
S
D
E
E
G
F
S
Y
T
R
K
L
A
K
K
N
G
L
L
V
G
S
S
S
G
A
-
A
F
V
A
A
L
K
E
A
Q
R
---
L
-
P
-
E
G
-
S
Q
V
L
T
I
F
P
D
V
A
D
R
Y
L
S
---
K
---
G
I
Y
----
128
HHSearch
63.30
38%
22
- C3 -
3DWG
1
CYSM_MYCTU
A:
[3-310]
-
M
T
R
Y
D
S
L
L
Q
A
L
G
N
T
P
L
V
G
L
Q
R
L
-
S
---
P
R
W
DDGRD
G
P
H
--
V
R
L
W
A
--
K
L
E
D
R
N
P
T
G
S
I
K
D
R
P
A
V
R
M
I
E
Q
A
E
A
D
G
L
L
R
P
--
G
-
A
--
T
I
L
E
P
T
S
G
N
T
G
I
S
L
A
M
A
A
R
L
K
G
Y
R
L
I
C
V
M
P
E
N
T
S
V
E
R
R
Q
L
L
E
L
Y
G
A
Q
I
I
F
S
A
A
E
G
G
S
---
N
T
A
---
V
A
T
A
K
E
L
A
A
T
N
-
P
-
S
W
V
M
L
Y
-
Q
Y
G
N
P
A
N
T
D
S
H
-
Y
C
G
T
G
P
E
L
L
---
A
D
L
P
--
E
I
T
H
F
V
A
G
L
G
T
T
G
T
L
M
G
T
G
R
F
L
R
--
E
H
--
V
-
A
N
V
K
I
V
A
A
E
P
-
R
Y
G
E
G
V
-----
Y
-
A
---------------------
L
R
-
N
M
D
E
G
F
V
P
E
L
Y
D
P
E
I
L
T
A
R
Y
S
V
G
A
V
D
A
V
R
R
T
R
E
L
V
H
T
E
G
I
F
A
G
I
S
T
G
A
-
V
L
H
A
A
L
G
V
G
A
G
A
L
A
A
-
G
-
E
R
-
A
D
I
A
L
V
V
A
D
A
G
W
K
Y
L
S
---
T
---
G
A
Y
A
G
--