@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu30790: (2016-07-20 )
MLTEQPNWLMQRAQLTPERIALIYEDQTVTFAELFAASKRMAEQLAAHSVRKGDTAAILLQNRAEMVYAVHACFLLGVKAVLLNTKLSTHERLFQLEDSGSGFLLTDSSFEKKEYEHIVQTIDVDELMKEAAEEIEIEAYMQMDATATLMYTSGTTGKPKGVQQTFGNHYFSAVSSALNLGITEQDRWLIALPLFHISGLSALFKSVIYGMTVVLHQRFSVSDVLHSINRHEVTMISAVQTMLASLLEETNRCPESIRCILLGGGPAPLPLLEECREKGFPVFQSYGMTETCSQIVTLSPEFSMEKLGSAGKPLFSCEIKIERDGQVCEPYEHGEIMVKGPNVMKSYFNRESANEASFQNGWLKTGDLGYLDNEGFLYVLDRRSDLIISGGENIYPAEVESVLLSHPAVAEAGVSGAEDKKWGKVPHAYLVLHKPVSAGELTDYCKERLAKYKIPAKFFVLDRLPRNASNKLLRNQLKDARKGELL
Atome Classification :
(20 SA)
.........10.....-....20..--.----...--..30........40........50........60........70........80........90........100-------........---------110...--------.------------.-------------.--.120.---------..---....130--.--.--..--.---....140...-....150.......160-........170..-....---.180.......190.......200-.--.......210......--.220.......230.......240.......250-----..-----.-------....260....--...270......--.280-........290.......300--.......310..-..-...320.--..----..-..330.......340-.......350.......--------360.......370.......380.......390.......400.......410.......420.......430-...-.-----....440....-..-.450.-......460.......470.......480....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MLTEQ
P
N
W
L
M
-
Q
R
AQL-
T
P
E
R
I
A
L
I
--
Y
----EDQ--
T
V
T
F
A
E
L
F
A
A
S
K
R
M
A
E
Q
L
A
A
H
SVRKG
D
T
A
A
I
L
LQNR
A
E
M
V
Y
A
V
H
A
C
F
L
L
G
V
K
A
V
L
LNTKL
S
T
H
E
R
L
F
Q
LEDSGS--------
G
F
L
L
TDSS---------F
E
K
K
E
Y
--------
E
------------
H
-------------
I
--
V
Q
TI
D
---------
V
D
---
E
L
M
K
E
----
A
--
A
--
E
E
--
I
---
E
I
E
A
Y
M
QMD
A
-
T
A
T
L
M
YTSGTTGKPK
G
--
V
Q
Q
T
F
G
N
H
Y
F
S
A
V
-
S
S
A
L
---NLGITEQD
R
W
L
I
A
L
P
L
F
H
IS
G
L
S
--
A
--
L
F
K
S
V
I
Y
G
M
T
V
V
L
HQR--F
S
V
S
D
V
L
H
S
INR
H
E
V
T
M
I
S
A
V
Q
T
M
L
A
S
L
L
E
E
T
NR-----
C
P
-----
E
-------
S
I
R
C
I
L
LGGGP--A
P
L
P
L
L
E
E
C
R
EK--G
F
P
--
V
F
Q
SYG
M
T
E
T
C
S
Q
I
V
TLSPEF--
S
M
E
K
LGSAGK
P
L
-
F
S
-
C
E
I
K
I
ER--DG----QV-CEPYEHG
E
I
M
V
KG
P
N
-
V
M
K
S
Y
FNRESANEASFQ--------NGWLKTGDLGYLDNE
G
F
L
Y
V
L
DRRS
D
L
I
I
SGGENI
Y
P
A
E
V
E
S
V
L
LSHP
A
V
A
EAGVSGAEDKKWGKV
P
H
A
Y
L
V
--
L
HK-P-----VS
A
G
E
L
T
D
Y
C
K
-
E
R
-
L
A
KYK-IP
A
K
F
F
V
LDRLPRNA
S
N
K
L
L
R
N
Q
L
K
D
ARKGELL
2
PsiBlast_PDB
83.79
100%
-104
- C2 -
5BUS
3
MENE_BACSU
A:
[5-487]
--
T
E
Q
P
N
W
L
M
-
Q
R
A
Q
L
-
T
P
E
R
I
A
L
I
--
Y
----
E
D
Q
--
T
V
T
F
A
E
L
F
A
A
S
K
R
M
A
E
Q
L
A
A
H
S
V
R
K
G
D
T
A
A
I
L
L
Q
N
R
A
E
M
V
Y
A
V
H
A
C
F
L
L
G
V
K
A
V
L
L
N
T
K
L
S
T
H
E
R
L
F
Q
L
E
D
S
G
S
--------
G
F
L
L
T
D
S
S
---------
F
E
K
K
E
Y
--------
E
------------
H
-------------
I
--
V
Q
T
I
D
---------
V
D
---
E
L
M
K
E
----
A
--
A
--
E
E
--
I
---
E
I
E
A
Y
M
Q
M
D
A
-
T
A
T
L
M
Y
T
S
G
T
T
G
K
P
K
G
--
V
Q
Q
T
F
G
N
H
Y
F
S
A
V
-
S
S
A
L
---
N
L
G
I
T
E
Q
D
R
W
L
I
A
L
P
L
F
H
I
S
G
L
S
--
A
--
L
F
K
S
V
I
Y
G
M
T
V
V
L
H
Q
R
--
F
S
V
S
D
V
L
H
S
I
N
R
H
E
V
T
M
I
S
A
V
Q
T
M
L
A
S
L
L
E
E
T
N
R
-----
C
P
-----
E
-------
S
I
R
C
I
L
L
G
G
G
P
--
A
P
L
P
L
L
E
E
C
R
E
K
--
G
F
P
--
V
F
Q
S
Y
G
M
T
E
T
C
S
Q
I
V
T
L
S
P
E
F
--
S
M
E
K
L
G
S
A
G
K
P
L
-
F
S
-
C
E
I
K
I
E
R
--
D
G
----
Q
V
-
C
E
P
Y
E
H
G
E
I
M
V
K
G
P
N
-
V
M
K
S
Y
F
N
R
E
S
A
N
E
A
S
F
Q
--------
N
G
W
L
K
T
G
D
L
G
Y
L
D
N
E
G
F
L
Y
V
L
D
R
R
S
D
L
I
I
S
G
G
E
N
I
Y
P
A
E
V
E
S
V
L
L
S
H
P
A
V
A
E
A
G
V
S
G
A
E
D
K
K
--
K
V
P
H
A
Y
L
V
--
L
H
K
-
P
-----
V
S
A
G
E
L
T
D
Y
C
K
-
E
R
-
L
A
K
Y
K
-
I
P
A
K
F
F
V
L
D
R
L
P
R
N
A
S
N
K
L
L
R
N
Q
L
K
D
A
R
K
G
E
L
-
22
PsiBlast_CBE
83.34
100%
-121
- C2 -
5BUQ
2
MENE_BACSU
B:
[5-488]
--
T
E
Q
P
N
W
L
M
-
Q
R
A
Q
L
-
T
P
E
R
I
A
L
I
--
Y
----
E
D
Q
--
T
V
T
F
A
E
L
F
A
A
S
K
R
M
A
E
Q
L
A
A
H
S
V
R
K
G
D
T
A
A
I
L
L
Q
N
R
A
E
M
V
Y
A
V
H
A
C
F
L
L
G
V
K
A
V
L
L
N
T
K
L
S
T
H
E
R
L
F
Q
L
E
D
S
G
S
--------
G
F
L
L
T
D
S
S
---------
F
E
K
K
E
Y
--------
E
------------
H
-------------
I
--
V
Q
T
I
D
---------
V
D
---
E
L
M
K
E
----
A
--
A
--
E
E
--
I
---
E
I
E
A
Y
M
Q
M
D
A
-
T
A
T
L
M
Y
T
S
----
K
P
K
G
--
V
Q
Q
T
F
G
N
H
Y
F
S
A
V
-
S
S
A
L
---
N
L
G
I
T
E
Q
D
R
W
L
I
A
L
P
L
F
H
I
S
G
L
S
--
A
--
L
F
K
S
V
I
Y
G
M
T
V
V
L
H
Q
R
--
F
S
V
S
D
V
L
H
S
I
N
R
H
E
V
T
M
I
S
A
V
Q
T
M
L
A
S
L
L
E
E
T
N
R
-----
C
P
-----
E
-------
S
I
R
C
I
L
L
G
G
G
P
--
A
P
L
P
L
L
E
E
C
R
E
K
--
G
F
P
--
V
F
Q
S
Y
G
M
T
E
T
C
S
Q
I
V
T
L
S
P
E
F
--
S
M
E
K
L
G
S
A
G
K
P
L
-
F
S
-
C
E
I
K
I
E
R
--
D
G
----
Q
V
-
C
E
P
Y
E
H
G
E
I
M
V
K
G
P
N
-
V
M
K
S
Y
F
N
R
E
S
A
N
E
A
S
F
Q
--------
N
G
W
L
K
T
G
D
L
G
Y
L
D
N
E
G
F
L
Y
V
L
D
---
D
L
I
I
S
G
G
E
N
I
Y
P
A
E
V
E
S
V
L
L
S
H
P
A
V
A
E
A
G
V
S
G
A
E
D
K
----
V
P
H
A
Y
L
V
--
L
H
K
-
P
-----
V
S
A
G
E
L
T
D
Y
C
K
-
E
R
-
L
A
K
Y
K
-
I
P
A
K
F
F
V
L
D
R
L
P
R
N
A
S
N
K
L
L
R
N
Q
L
K
D
A
R
K
G
E
L
L
1
PsiBlast_PDB
83.20
100%
-104
- C2 -
5BUR
9
MENE_BACSU
A:
[5-481]
--
T
E
Q
P
N
W
L
M
-
Q
R
A
Q
L
-
T
P
E
R
I
A
L
I
--
Y
----
E
D
Q
--
T
V
T
F
A
E
L
F
A
A
S
K
R
M
A
E
Q
L
A
A
H
S
V
R
K
G
D
T
A
A
I
L
L
Q
N
R
A
E
M
V
Y
A
V
H
A
C
F
L
L
G
V
K
A
V
L
L
N
T
K
L
S
T
H
E
R
L
F
Q
L
E
D
S
G
S
--------
G
F
L
L
T
D
S
S
---------
F
E
K
K
E
Y
--------
E
------------
H
-------------
I
--
V
Q
T
I
D
---------
V
D
---
E
L
M
K
E
----
A
--
A
--
E
E
--
I
---
E
I
E
A
Y
M
Q
M
D
A
-
T
A
T
L
M
Y
T
S
G
T
T
G
K
P
K
G
--
V
Q
Q
T
F
G
N
H
Y
F
S
A
V
-
S
S
A
L
---
N
L
G
I
T
E
Q
D
R
W
L
I
A
L
P
L
F
H
I
S
G
L
S
--
A
--
L
F
K
S
V
I
Y
G
M
T
V
V
L
H
Q
R
--
F
S
V
S
D
V
L
H
S
I
N
R
H
E
V
T
M
I
S
A
V
Q
T
M
L
A
S
L
L
E
E
T
N
R
-----
C
P
-----
E
-------
S
I
R
C
I
L
L
G
G
G
P
--
A
P
L
P
L
L
E
E
C
R
E
K
--
G
F
P
--
V
F
Q
S
Y
G
M
T
E
T
C
S
Q
I
V
T
L
S
P
E
F
--
S
M
E
K
L
G
S
A
G
K
P
L
-
F
S
-
C
E
I
K
I
E
R
--
D
G
----
Q
V
-
C
E
P
Y
E
H
G
E
I
M
V
K
G
P
N
-
V
M
K
S
Y
F
N
R
E
S
A
N
E
A
S
F
Q
--------
N
G
W
L
K
T
G
D
L
G
Y
L
D
N
E
G
F
L
Y
V
L
D
R
R
S
D
L
I
I
S
G
G
E
N
I
Y
P
A
E
V
E
S
V
L
L
S
H
P
A
V
A
E
A
G
V
S
G
A
E
D
K
--
G
K
V
P
H
A
Y
L
V
--
L
H
K
-
P
-----
V
S
A
G
E
L
T
D
Y
C
K
-
E
R
-
L
A
K
Y
K
-
I
P
A
K
F
F
V
L
D
R
L
P
R
N
A
S
N
K
L
L
R
N
Q
L
K
D
-------
21
PsiBlast_CBE
73.57
100%
-126
- C2 -
5BUS
4
MENE_BACSU
B:
[5-388]
--
T
E
Q
P
N
W
L
M
-
Q
R
A
Q
L
-
T
P
E
R
I
A
L
I
--
Y
----
E
D
Q
--
T
V
T
F
A
E
L
F
A
A
S
K
R
M
A
E
Q
L
A
A
H
S
V
R
K
G
D
T
A
A
I
L
L
Q
N
R
A
E
M
V
Y
A
V
H
A
C
F
L
L
G
V
K
A
V
L
L
N
T
K
L
S
T
H
E
R
L
F
Q
L
E
D
S
G
S
--------
G
F
L
L
T
D
S
S
---------
F
E
K
K
E
Y
--------
E
------------
H
-------------
I
--
V
Q
T
I
D
---------
V
D
---
E
L
M
K
E
----
A
--
A
--
E
E
--
I
---
E
I
E
A
Y
M
Q
M
D
A
-
T
A
T
L
M
Y
T
S
G
T
T
G
K
P
K
G
--
V
Q
Q
T
F
G
N
H
Y
F
S
A
V
-
S
S
A
L
---
N
L
G
I
T
E
Q
D
R
W
L
I
A
L
P
L
F
H
I
S
G
L
S
--
A
--
L
F
K
S
V
I
Y
G
M
T
V
V
L
H
Q
R
--
F
S
V
S
D
V
L
H
S
I
N
R
H
E
V
T
M
I
S
A
V
Q
T
M
L
A
S
L
L
E
E
T
-------
C
P
-----
E
-------
S
I
R
C
I
L
L
G
G
G
P
---
P
L
P
L
L
E
E
C
R
E
K
--
G
F
P
--
V
F
Q
S
Y
G
M
T
E
T
C
S
Q
I
V
T
L
S
P
E
F
--
S
M
E
K
L
G
S
A
G
K
P
L
-
F
S
-
C
E
I
K
I
E
R
--
D
G
----
Q
V
-
C
E
P
Y
E
H
G
E
I
M
V
K
G
P
N
-
V
M
K
S
Y
F
N
R
E
S
A
N
E
A
S
F
Q
--------
N
G
W
L
K
T
G
D
L
G
Y
L
D
N
E
G
F
L
Y
V
L
D
R
R
S
D
L
---------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
57.99
33%
-126
- C- -
3IPL
-
MENE_STAAN
A:
[4-477]
-------
W
L
Y
-
K
Q
A
Q
Q
-
N
G
H
H
I
A
I
T
--
D
----
G
Q
E
--
S
Y
T
Y
Q
N
L
Y
C
E
A
S
L
L
A
K
R
L
K
A
Y
Q
Q
S
R
---
V
G
L
Y
I
D
N
S
I
Q
S
I
I
L
I
H
A
C
W
L
A
N
I
E
I
A
M
I
N
T
R
L
T
P
N
E
M
T
N
Q
M
R
S
I
D
V
--------
Q
L
I
F
C
T
L
P
---------
L
E
L
R
G
F
--------
Q
--------------------------
I
--
V
S
L
D
D
------------------
E
----
S
--
P
--
S
N
--
I
----
L
N
T
S
F
N
L
D
D
-
I
A
S
I
M
F
T
S
G
T
T
G
P
Q
K
A
--
V
P
Q
T
F
R
N
H
Y
A
S
A
I
-
G
C
K
E
---
S
L
G
F
D
R
D
T
N
W
L
S
V
L
P
I
Y
H
I
S
G
L
S
--
V
--
L
L
R
A
V
I
E
G
F
T
V
R
I
V
D
K
--
F
N
A
E
Q
I
L
T
M
I
K
N
E
R
I
T
H
I
S
L
V
P
Q
T
L
N
W
L
M
Q
Q
G
L
H
-----
E
P
-----
Y
-------
N
L
Q
K
I
L
L
G
G
A
K
--
L
S
A
T
M
I
E
T
A
L
Q
Y
--
N
L
P
--
I
Y
N
S
F
G
M
T
E
T
C
S
Q
F
L
T
A
T
P
E
M
--
L
H
A
R
P
D
T
V
G
M
P
S
-
A
N
-
V
D
V
K
I
K
N
--
P
N
----
K
E
-
G
----
H
G
E
L
M
I
K
G
A
N
-
V
M
N
G
Y
L
Y
P
T
D
L
T
-
G
T
F
E
--------
N
G
Y
F
N
T
G
D
I
A
E
I
D
H
E
G
Y
V
M
I
Y
D
R
R
K
D
L
I
I
S
G
G
E
N
I
Y
P
Y
Q
I
E
T
V
A
K
Q
F
P
G
I
S
D
A
V
C
V
G
H
P
D
D
T
W
G
Q
V
P
K
L
Y
F
V
--
S
E
S
-
D
-----
I
S
K
A
Q
L
I
A
Y
L
S
-
K
H
-
L
A
K
Y
K
-
V
P
K
H
F
E
K
V
D
T
L
P
---------------------
4
PsiBlast_PDB
57.29
33%
-4
- C2 -
3R44
2
FAC13_MYCTU
A:
[19-509]
------
G
W
M
L
R
Q
R
A
T
V
-
S
P
R
L
Q
A
Y
V
EP
S
----
T
D
V
--
R
M
T
Y
A
Q
M
N
A
L
A
N
R
C
A
D
V
L
T
A
L
G
I
A
K
G
D
R
V
A
L
L
M
P
N
S
V
E
F
C
C
L
F
Y
G
A
A
K
L
G
A
V
A
V
P
I
N
T
R
L
A
A
P
E
V
S
F
I
L
S
D
S
G
S
--------
K
V
V
I
Y
G
A
P
S
A
P
V
I
D
A
I
R
A
Q
A
D
P
P
--------
G
------------
T
-------------
V
--
T
D
W
I
G
---------
A
D
---
S
L
A
E
R
L
R
S
A
A
--
A
--
D
E
--
P
---
A
V
E
C
--
G
G
D
D
-
N
L
F
I
M
Y
T
S
---
G
H
P
K
G
--
V
V
H
T
H
E
S
V
H
S
A
A
S
-
S
W
A
S
---
T
I
D
V
R
Y
R
D
R
L
L
L
P
L
P
M
F
H
V
A
A
L
T
--
T
--
V
I
F
S
A
M
R
G
V
T
L
I
S
M
P
Q
--
F
D
A
T
K
V
W
S
L
I
V
E
E
R
V
C
I
G
G
A
V
P
A
I
L
N
F
M
----
R
Q
-----
V
P
-----
E
F
A
E
LDAP
D
F
R
Y
F
I
T
G
G
A
P
--
M
P
E
A
L
I
K
I
Y
A
A
K
--
N
I
E
--
V
V
Q
G
Y
A
L
T
E
S
C
G
G
G
T
L
L
L
S
E
D
--
A
L
R
K
A
G
S
A
G
R
A
T
-
M
F
-
T
D
V
A
V
R
G
--
D
D
----
G
V
-
I
R
E
H
G
E
G
E
V
V
I
K
S
D
I
-
L
L
K
E
Y
W
N
R
P
E
A
T
R
D
A
F
D
--------
N
G
W
F
R
T
G
D
I
G
E
I
D
D
E
G
Y
L
Y
I
K
D
R
L
K
D
M
I
I
S
G
G
E
N
V
Y
P
A
E
I
E
S
V
I
I
G
V
P
G
V
S
E
V
A
V
I
G
L
P
D
E
K
W
G
E
I
A
A
A
I
V
V
--
A
D
Q
N
E
-----
V
S
E
Q
Q
I
V
E
Y
C
G
-
T
R
-
L
A
R
Y
K
-
L
P
K
K
V
I
F
A
E
A
I
P
R
N
P
T
G
K
I
L
K
T
V
L
R
E
-------
68
HHSearch
56.57
27%
-33
- C2 -
4WV3
1
?
A:
[13-518]
-----
V
D
I
L
E
-
R
N
L
P
V
-
R
A
N
K
T
A
L
F
--
T
----
P
D
R
--
E
M
T
F
R
Q
V
S
N
E
A
N
Q
V
G
N
A
L
K
G
L
G
V
R
F
G
E
C
V
G
L
L
T
L
D
S
A
E
W
V
T
S
F
F
G
I
V
K
L
G
A
I
A
V
G
I
N
T
L
L
K
P
P
E
Y
E
Y
I
L
R
D
C
R
A
--------
R
V
L
I
V
H
Q
E
---------
F
L
P
L
I
E
--------
S
I
RGNLPMLE---
H
-------------
I
--
V
V
I
G
-GYLS-----
F
N
---
D
W
I
R
P
-------
Q
--
P
T
--
T
---
L
E
A
A
Q
S
H
R
E
D
-
I
C
S
L
N
Y
S
S
G
-
T
G
G
P
K
G
--
I
P
H
A
H
K
D
Y
P
L
T
A
Q
L
W
G
V
N
---
V
L
G
L
R
E
S
D
R
T
F
A
L
A
K
L
F
F
T
F
G
T
G
--
G
N
-
L
I
F
P
W
Y
V
G
A
S
C
V
L
F
P
G
AA
R
V
A
S
N
V
L
S
T
I
S
R
F
K
P
T
I
F
Y
N
A
P
T
G
Y
A
A
A
L
A
L
K
D
F
SQH--
D
L
-----
S
-------
S
L
R
L
C
V
S
A
S
E
A
--
L
P
A
A
L
W
Y
A
W
K
E
A
T-
G
V
D
--
I
I
D
G
I
G
C
T
E
N
F
H
I
F
I
S
N
R
P
G
----
D
I
R
P
G
S
S
G
K
P
V
-
E
G
-
Y
E
L
K
L
V
D
D-
E
G
----
K
T
-
V
P
A
G
E
I
G
N
V
L
L
R
S
E
T
-
A
A
L
S
Y
W
H
N
F
E
K
S
R
Q
T
F
Q
--------
G
E
W
L
A
T
G
D
K
Y
F
V
D
A
D
G
Y
Y
W
H
A
G
R
S
D
D
M
L
K
V
G
G
I
W
V
S
P
V
E
V
E
S
T
L
I
Q
H
P
A
V
Q
E
C
A
V
I
G
C
P
D
Q
S
R
L
I
K
P
K
A
F
I
I
--
L
K
P
-
E
Q
I
P
S
E
A
L
I
R
Q
I
T
D
H
C
T
-
E
K
-
M
A
A
Y
K
-
R
P
R
W
I
E
F
V
T
E
L
P
K
T
A
T
G
K
I
Q
R
F
K
L
R
S
A
A
K
L
---
70
HHSearch
56.45
34%
-5
- C2 -
3R44
2
FAC13_MYCTU
A:
[17-515]
---
N
I
G
W
M
L
R
-
Q
R
A
T
V
-
S
P
R
L
Q
A
Y
V
--
E
PS--
T
D
V
--
R
M
T
Y
A
Q
M
N
A
L
A
N
R
C
A
D
V
L
T
A
L
G
I
A
K
G
D
R
V
A
L
L
M
P
N
S
V
E
F
C
C
L
F
Y
G
A
A
K
L
G
A
V
A
V
P
I
N
T
R
L
A
A
P
E
V
S
F
I
L
S
D
S
G
S
--------
K
V
V
I
Y
G
A
P
---------
S
A
P
V
I
D
--------
A
I
R
A
QADP-----
P
-------------
G
TV
T
D
W
I
G
---------
A
D
---
S
L
A
E
R
----
L
--
R
S
A
A
A
--
D
---
E
P
A
V
E
C
G
G
D
D
-
N
L
F
I
M
Y
T
S
---
G
H
P
K
G
--
V
V
H
T
H
E
S
V
H
S
A
A
S
-
S
W
A
S
---
T
I
D
V
R
Y
R
D
R
L
L
L
P
L
P
M
F
H
V
A
A
L
T
--
T
--
V
I
F
S
A
M
R
G
V
T
L
I
S
M
P
Q
--
F
D
A
T
K
V
W
S
L
I
V
E
E
R
V
C
I
G
G
A
V
P
A
I
L
N
F
M
R
Q
V
P
E
F
A
E
L--
D
A
-----
P
-------
D
F
R
Y
F
I
T
G
G
A
P
--
M
P
E
A
L
I
K
I
Y
A
A
K
--
N
I
E
--
V
V
Q
G
Y
A
L
T
E
S
C
G
G
G
T
L
L
L
S
E
D
--
A
L
R
K
A
G
S
A
G
R
A
T
-
M
F
-
T
D
V
A
V
R
G
--
D
D
----
G
V
-
I
R
E
H
G
E
G
E
V
V
I
K
S
D
I
-
L
L
K
E
Y
W
N
R
P
E
A
T
R
D
A
F
D
--------
N
G
W
F
R
T
G
D
I
G
E
I
D
D
E
G
Y
L
Y
I
K
D
R
L
K
D
M
I
I
S
G
G
E
N
V
Y
P
A
E
I
E
S
V
I
I
G
V
P
G
V
S
E
V
A
V
I
G
L
P
D
E
K
W
G
E
I
A
A
A
I
V
V
--
A
D
Q
N
E
-----
V
S
E
Q
Q
I
V
E
Y
C
G
-
T
R
-
L
A
R
Y
K
-
L
P
K
K
V
I
F
A
E
A
I
P
R
N
P
T
G
K
I
L
K
T
V
L
R
E
Q
Y
S
A
T
V
-
73
HHSearch
56.00
24%
-17
- C2 -
1MDB
4
DHBE_BACSU
A:
[29-533]
------
D
L
L
R
-
D
R
A
A
K
-
Y
G
D
R
I
A
I
T
--
C
----
G
N
T
--
H
W
S
Y
R
E
L
D
T
R
A
D
R
L
A
A
G
F
Q
K
L
G
I
Q
Q
K
D
R
V
V
V
Q
L
P
N
I
K
E
F
F
E
V
I
F
A
L
F
R
L
G
A
L
P
V
F
A
L
P
S
H
R
S
S
E
I
T
Y
F
C
E
F
A
E
A
--------
A
A
Y
I
I
P
D
A
---------
Y
S
G
F
D
Y
R
S
L
A
R
Q
V
Q
S
K
L
PTLK------
N
-------------
I
--
I
V
A
G
E
---------
A
E
---
E
F
L
P
L
----
E
DL
H
--
T
E
--
P
---
V
K
L
P
E
V
K
S
S
D
-
V
A
F
L
Q
L
S
G
G
S
T
G
L
S
K
L
--
I
P
R
T
H
D
D
Y
I
Y
S
L
K
-
R
S
V
E
---
V
C
W
L
D
H
S
T
V
Y
L
A
A
L
P
M
A
H
N
Y
P
L
S
SP
G
--
V
L
G
V
L
Y
A
G
G
R
V
V
L
S
P
S
--
P
S
P
D
D
A
F
P
L
I
E
R
E
K
V
T
I
T
A
L
V
P
P
L
A
M
V
W
M
D
A
A
S
S
RRD--
D
L
-----
S
-------
S
L
Q
V
L
Q
V
G
G
A
K
--
F
S
A
E
A
A
R
R
V
K
A
V
F-
G
C
T
--
L
Q
Q
V
F
G
M
A
E
G
L
V
N
Y
T
R
L
D
D
P
---
E
E
I
I
V
N
T
Q
G
K
P
M
-
S
P
Y
D
E
S
R
V
W
D
D-
H
D
----
R
D
-
V
K
P
G
E
T
G
H
L
L
T
R
G
P
Y
-
T
I
R
G
Y
Y
K
A
E
E
H
N
A
A
S
F
T
E-------
D
G
F
Y
R
T
G
D
I
V
R
L
T
R
D
G
Y
I
V
V
E
G
R
A
K
D
Q
I
N
R
G
G
E
K
V
A
A
E
E
V
E
N
H
L
L
A
H
P
A
V
H
D
A
A
M
V
S
M
P
D
Q
F
L
G
E
R
S
C
V
F
I
I
--
P
R
D
-
E
A----
P
K
A
A
E
L
K
A
F
L
R
-
E
R
G
L
A
A
Y
K
-
I
P
D
R
V
E
F
V
E
S
F
P
Q
T
G
V
G
K
V
S
K
K
A
L
R
E
A
I
S
E
K
L
-
16
PsiBlast_PDB
53.34
30%
-13
- C2 -
1T5H
1
?
X:
[8-498]
--------
L
R
-
R
A
A
T
R
-
A
P
D
H
C
A
L
A
--
V
----
P
A
R
GL
R
L
T
H
A
E
L
R
A
R
V
E
A
V
A
A
R
L
H
A
D
G
L
R
P
Q
Q
R
V
A
V
V
A
P
N
S
A
D
V
V
I
A
I
L
A
L
H
R
L
G
A
V
P
A
L
L
N
P
R
L
K
S
A
E
-
L
A
E
L
I
K
R
G
E
MTAAVIAV--
Q
V
A
D
A
I
---------
F
Q
S
G
S
G
--------
A
------------
R
-------------
I
--
I
F
L
G
D
---------
L
V
---
R
D
G
E
P
----
Y
--
S
--
Y
G
--
P
---
P
I
E
D
P
Q
R
E
P
A
Q
P
A
F
I
F
Y
T
S
---
G
L
P
K
A
AI
I
P
Q
R
A
A
E
S
R
V
L
F
M
-
S
T
Q
V
---
G
L
R
H
G
R
H
N
V
V
L
G
L
M
P
L
Y
H
V
V
G
F
F
--
A
V-
L
V
A
A
L
A
L
D
G
T
Y
V
V
V
E
E
--
F
R
P
V
D
A
L
Q
L
V
Q
Q
E
Q
V
T
S
L
F
A
T
P
T
H
L
D
A
L
A
A
A
A
A
H
-----
A
G
SSLKL
D
-------
S
L
R
H
V
T
F
A
G
A
T
--
M
P
D
A
V
L
E
T
V
H
Q
H
---
L
P
GE
K
V
N
I
Y
G
T
T
E
A
M
N
S
L
Y
M
R
Q
P
-------
K
T
G
T
E
M
A
P
G
-
F
F
-
S
E
V
R
I
V
R
--
I
G
GGVD
E
I
-
V
A
N
G
E
E
G
E
L
I
V
A
A
S
D
S
A
F
V
G
Y
L
N
Q
P
Q
A
T
A
E
K
L
Q
--------
D
G
W
Y
R
T
S
D
V
A
V
W
T
P
E
G
T
V
R
I
L
G
R
V
D
D
M
I
I
S
G
G
E
N
I
H
P
S
E
I
E
R
V
L
G
T
A
P
G
V
T
E
V
V
V
I
G
L
A
D
Q
R
W
G
Q
S
V
T
A
C
V
V
PR
L
G
E
-
T
-----
L
S
A
D
A
L
D
T
F
C
R
S
S
E
-
L
A
D
F
K
-
R
P
K
R
Y
F
I
L
D
Q
L
P
K
N
A
L
N
K
V
L
R
R
Q
L
---------
69
HHSearch
53.13
24%
-28
- C2 -
5E7Q
11
?
A:
[8-511]
----
I
G
D
V
L
R
-
E
H
R
R
S
-
H
P
G
R
T
A
L
V
--
D
----
G
P
V
--
R
L
T
W
P
E
L
D
D
R
V
N
R
L
A
G
S
L
A
A
S
G
I
G
R
G
D
R
I
M
W
L
G
Q
N
S
F
R
V
Y
E
L
I
A
A
A
G
K
L
G
A
M
V
C
V
G
Y
W
R
W
A
P
P
E
M
E
F
A
L
R
D
F
D
P
--------
H
L
V
V
W
Q
H
Q
---------
E
I
H
E
T
V
--------
A
R
T
R
E
A
L
GSDDT
A
R
-------------
W
--
L
R
H
D
S
APQDPDG--
Y
E
---
A
F
L
A
A
-------
G
--
G
L
--
A
---
D
P
D
L
D
I
D
P
D
S
-
P
V
L
V
L
Y
T
A
----
R
Q
C
G
--
S
L
L
S
H
T
N
L
I
A
M
A
T
-
A
A
A
W
---
L
G
D
I
D
H
T
T
A
F
L
N
S
G
P
M
F
H
I
G
N
H
Q
--
F
W-
G
M
P
T
L
L
M
A
G
K
N
V
I
V
R
R
--
V
V
A
E
E
V
R
D
L
L
V
A
E
E
C
T
H
A
F
L
M
P
P
T
V
A
E
I
V
R
L
N
R
D
TGH--
D
L
-----
S
-------
R
L
R
A
T
V
A
P
H
L
W
EG
M
A
T
T
D
T
S
R
F
T
R
S
--
G
A
A
--
A
G
R
G
Y
G
Q
T
E
L
S
G
F
A
V
T
A
A
Y
G
----
G
P
A
A
G
N
A
G
R
P
G
-
P
G
-
L
T
V
R
V
L
D
T-
A
G
----
R
E
-
C
A
V
G
E
A
G
E
I
C
A
R
G
T
V
-
V
H
R
G
Y
W
N
R
D
E
V
N
A
H
R
F
R
--------
S
G
W
W
H
T
T
D
L
G
R
R
E
P
D
G
S
L
T
F
L
G
T
T
T
R
M
L
K
S
A
A
E
N
I
F
P
A
E
V
E
N
C
I
E
Q
H
P
A
V
R
E
A
A
V
I
G
V
P
N
T
R
W
A
Q
D
V
K
A
V
V
V
--
L
E
P
-
D
A
G
---
V
S
E
Q
E
I
I
D
H
C
R
-
P
R
-
I
A
S
Y
K
-
K
P
K
S
V
A
F
A
A
A
L
P
R
T
V
S
G
A
R
D
Y
D
A
L
D
K
E
Y
G
G
---
15
PsiBlast_PDB
53.06
30%
-9
- C2 -
3DLP
1
?
X:
[5-498]
------
N
E
M
L
-
R
R
A
A
T
R
A
P
D
H
C
A
L
A
--
V
----
P
A
R
GL
R
L
T
H
A
E
L
R
A
R
V
E
A
V
A
A
R
L
H
A
D
G
L
R
P
Q
Q
R
V
A
V
V
A
P
N
S
A
D
V
V
I
A
I
L
A
L
H
R
L
G
A
V
P
A
L
L
N
P
R
L
K
S
A
E
-
L
A
E
L
I
K
R
G
E
MTAAVIAV
G
R
Q
V
A
D
A
I
---------
F
Q
S
G
S
G
--------
A
------------
R
-------------
I
--
I
F
L
G
D
---------
L
V
---
R
D
G
E
P
----
Y
--
S
--
Y
G
--
P
---
P
I
E
D
P
Q
R
E
P
A
Q
P
A
F
I
F
Y
T
S
G
T
T
G
L
P
K
A
AI
I
P
Q
R
A
A
E
S
R
V
L
F
M
-
S
T
Q
V
---
G
L
R
H
G
R
H
N
V
V
L
G
L
M
P
L
Y
H
V
V
G
F
F
--
A
V-
L
V
A
A
L
A
L
D
G
T
Y
V
V
V
E
E
--
F
R
P
V
D
A
L
Q
L
V
Q
Q
E
Q
V
T
S
L
F
A
T
P
T
H
L
D
A
L
A
A
A
A
A
H
-----
A
G
SSLKL
D
-------
S
L
R
H
V
T
F
A
G
A
T
--
M
P
D
A
V
L
E
T
V
H
Q
H
---
L
P
GE
K
V
N
I
Y
G
T
T
E
A
M
N
S
L
Y
M
R
Q
P
-------
K
T
G
T
E
M
A
P
G
-
F
F
-
S
E
V
R
I
V
R
--
I
G
GGVD
E
I
-
V
A
N
G
E
E
G
E
L
I
V
A
A
S
D
S
A
F
V
G
Y
L
N
Q
P
Q
A
T
A
E
K
L
Q
--------
D
G
W
Y
R
T
S
D
V
A
V
W
T
P
E
G
T
V
R
I
L
G
R
V
P
D
M
I
I
S
G
G
E
N
I
H
P
S
E
I
E
R
V
L
G
T
A
P
G
V
T
E
V
V
V
I
G
L
A
D
Q
R
W
G
Q
S
V
T
A
C
V
V
PR
L
G
E
-
T
-----
L
S
A
D
A
L
D
T
F
C
R
S
S
E
-
L
A
D
F
K
-
R
P
K
R
Y
F
I
L
D
Q
L
P
K
N
A
L
N
K
V
L
R
R
Q
L
---------
72
HHSearch
52.34
19%
-52
- C2 -
4DG8
3
?
A:
[29-512]
----
V
V
A
R
F
S
-
E
M
A
A
L
-
H
P
H
R
E
A
I
R
--
D
----
R
F
G
--
S
V
D
Y
R
Q
L
L
D
S
A
E
Q
L
S
D
Y
L
L
E
H
Y
P
Q
P
G
V
C
L
G
V
Y
G
E
Y
S
R
E
S
I
T
C
L
L
A
I
L
L
S
G
H
H
Y
L
Y
I
D
L
K
Q
P
A
A
W
N
A
E
L
C
R
Q
V
D
C
--------
R
L
I
L
D
C
S
T
---------
T
P
T
P
A
N
--------
G
-----------------------------
L
P
C
V
P
---------
V
R
---
H
L
P
A
--------
A
--
P
A
--
S
---
V
A
R
P
C
F
A
A
D
Q
-
I
A
Y
I
N
F
S
S
G
T
T
G
R
P
K
A
--
I
A
C
T
H
A
G
I
T
R
L
C
L
-
G
Q
-
S
---
F
L
A
F
A
P
Q
M
R
F
L
V
N
S
P
L
S
F
D
A
A
T
L
--
E
--
I
W
G
A
L
L
N
G
G
C
C
V
L
N
D
L
GP
L
D
P
G
V
L
R
Q
L
I
G
E
R
G
A
D
S
A
W
L
T
A
S
L
F
N
T
L
V
D
L
D
P
D
-----
C
L
-----
G
-------
G
L
R
Q
L
L
T
G
G
D
I
--
L
S
V
P
H
V
R
R
A
L
L
R
H
P
R
L
H
--
L
V
N
G
Y
G
P
T
E
N
T
T
F
T
C
C
H
V
V
T
D
D
D
L
E
E
D
D
I
P
I
G
K
A
I
-
A
G
-
T
A
V
L
L
L
D
E-
H
G
----
Q
E
I
A
E
P
D
R
A
G
E
I
V
A
F
G
A
G
-
L
A
Q
G
Y
R
N
D
A
A
R
T
R
A
S
F
V
E
L
P
Y
RG
R
L
L
R
A
Y
R
T
G
D
R
A
R
Y
D
E
Q
G
R
L
R
F
I
G
R
G
D
G
Q
V
K
L
N
G
Y
R
L
D
L
P
A
L
E
Q
R
F
R
R
Q
P
G
I
L
D
C
A
L
L
V
R
E
R
N
G
V
K
-
Q
L
L
C
A
W
T
--
G
----------
K
A
D
A
S
P
Q
A
L
L
-
R
Q
-
L
P
T
W
Q
-
R
P
H
A
C
V
R
V
E
A
L
P
L
T
----
L
D
R
A
A
L
L
R
R
L
E
----
14
PsiBlast_PDB
52.28
30%
-8
- C2 -
3CW8
5
?
X:
[5-498]
------
N
E
M
L
-
R
R
A
A
T
R
A
P
D
H
C
A
L
A
--
V
----
P
A
R
GL
R
L
T
H
A
E
L
R
A
R
V
E
A
V
A
A
R
L
H
A
D
G
L
R
P
Q
Q
R
V
A
V
V
A
P
N
S
A
D
V
V
I
A
I
L
A
L
H
R
L
G
A
V
P
A
L
L
N
P
R
L
K
S
A
E
-
L
A
E
L
I
K
R
G
E
MTAAVIAV
G
R
Q
V
A
D
A
I
---------
F
Q
S
G
S
G
--------
A
------------
R
-------------
I
--
I
F
L
G
D
---------
L
V
---
R
D
G
E
P
----
Y
--
S
--
Y
G
--
P
---
P
I
E
D
P
Q
R
E
P
A
Q
P
A
F
I
F
Y
T
S
G
T
T
G
L
P
K
A
AI
I
P
Q
R
A
A
E
S
R
V
L
F
M
-
S
T
Q
V
---
G
L
R
H
G
R
H
N
V
V
L
G
L
M
P
L
Y
H
V
V
G
F
F
--
A
V-
L
V
A
A
L
A
L
D
G
T
Y
V
V
I
E
E
--
F
R
P
V
D
A
L
Q
L
V
Q
Q
E
Q
V
T
S
L
F
A
T
P
T
H
L
D
A
L
A
A
A
A
A
H
-----
A
G
SSLKL
D
-------
S
L
R
H
V
T
F
A
G
A
T
--
M
P
D
A
V
L
E
T
V
H
Q
H
---
L
P
GE
K
V
N
I
Y
G
T
T
E
A
M
N
S
L
Y
M
R
Q
P
-------
K
T
G
T
E
M
A
P
G
-
F
F
-
S
E
V
R
I
V
R
--
I
G
GGVD
E
I
-
V
A
N
G
E
E
G
E
L
I
V
A
A
S
D
S
A
F
V
G
Y
L
N
Q
P
E
A
T
A
E
K
L
Q
--------
D
G
W
Y
R
T
S
D
V
A
V
W
T
P
E
G
T
V
R
I
L
G
R
V
D
D
M
I
I
S
G
G
E
N
I
H
P
S
E
I
E
R
V
L
G
T
A
P
G
V
T
E
V
V
V
I
G
L
A
D
Q
-
W
G
Q
S
V
T
A
C
V
V
PR
L
G
E
-
T
-----
L
S
A
D
A
L
D
T
F
C
R
S
S
E
-
L
A
D
F
K
-
R
P
K
R
Y
F
I
L
D
Q
L
P
K
N
A
L
N
K
V
L
R
R
Q
L
---------
60
HHSearch
52.21
26%
8
- C2 -
2D1S
3
LUCI_LUCCR
A:
[26-544]
-----
G
T
Q
L
R
-
K
Y
M
E
R
-
Y
A
K
L
G
A
I
A
--
F
TNAV
T
G
V
--
D
Y
S
Y
A
E
Y
L
E
K
S
C
C
L
G
K
A
L
Q
N
Y
G
L
V
V
D
G
R
I
A
L
C
S
E
N
C
E
E
F
F
I
P
V
I
A
G
L
F
I
G
V
G
V
A
P
T
N
E
I
Y
T
L
R
E
L
V
H
S
L
G
I
S
K
P
--------
T
I
V
F
S
S
K
K
---------
G
L
D
K
V
I
--------
T
V
Q
K
T
VTTI
K
---
T
-------------
I
--
V
I
L
D
S
KVDYRGYQ
C
L
D
---
T
F
I
K
R
----
N
--
T
P-
P
G
FQ
A
S
S
F
K
T
V
E
V
D
R
K
E
Q
-
V
A
L
I
M
N
S
S
G
S
T
G
L
P
K
G
--
V
Q
L
T
H
E
N
I
V
T
R
F
S
-
H
A
R
D
PIY
G
N
Q
V
S
P
G
T
A
V
L
T
V
V
P
F
H
H
G
F
G
M
F
--
T
--
T
L
G
Y
L
I
C
G
F
R
V
V
M
L
T
K
--
F
D
E
E
T
F
L
K
T
L
Q
D
Y
K
C
T
S
V
I
L
V
P
T
L
F
A
I
L
N
K
S
E
L
L
NKY--
D
L
-----
S
-------
N
L
V
E
I
A
S
G
G
A
P
--
L
S
K
E
V
G
E
A
V
A
R
R
FN
L
P
G
--
V
R
Q
G
Y
G
L
T
E
T
T
S
A
I
I
I
T
P
E
G
----
D
D
K
P
G
A
S
G
K
V
V
-
P
L
-
F
K
A
K
V
I
D
LD
T
K
----
K
S
-
L
G
P
N
R
R
G
E
V
C
V
K
G
P
M
-
L
M
K
G
Y
V
N
N
P
E
A
T
K
E
L
I
D
E-------
E
G
W
L
H
T
G
D
I
G
Y
Y
D
E
E
K
H
F
F
I
V
D
R
L
K
S
L
I
K
Y
K
G
Y
Q
V
P
P
A
E
L
E
S
V
L
L
Q
H
P
S
I
F
D
A
G
V
A
G
V
P
D
P
V
A
G
E
L
P
G
A
V
V
V
--
L
E
S
-
G
K
N
---
M
T
E
K
E
V
M
D
Y
V
A
-
S
Q
-
V
S
N
A
K
R
L
R
G
G
V
R
F
V
D
E
V
P
K
G
L
T
G
K
I
D
G
R
A
I
R
E
I
L
K
K
P
--
13
PsiBlast_PDB
52.21
30%
-6
- C2 -
3CW9
5
?
A:
[5-498]
------
N
E
M
L
-
R
R
A
A
T
R
A
P
D
H
C
A
L
A
--
V
----
P
A
R
G
L
R
L
T
H
A
E
L
R
A
R
V
E
A
V
A
A
R
L
H
A
D
G
L
R
P
Q
Q
R
V
A
V
V
A
P
N
S
A
D
V
V
I
A
I
L
A
L
H
R
L
G
A
V
P
A
L
L
N
P
R
L
K
S
A
E
-
L
A
E
L
I
K
R
G
E
MT
A
A
V
I
AV
G
R
Q
V
A
D
A
I
---------
F
Q
S
G
S
G
--------
A
------------
R
-------------
I
--
I
F
L
G
D
---------
L
V
---
R
D
G
E
P
----
Y
--
S
--
Y
G
--
P
---
P
I
E
D
P
Q
R
E
P
A
Q
P
A
F
I
F
Y
T
S
G
T
T
G
L
P
K
A
A
I
I
P
Q
R
A
A
E
S
R
V
L
F
M
-
S
T
Q
V
---
G
L
R
H
G
R
H
N
V
V
L
G
L
M
P
L
Y
H
V
V
G
F
F
--
A
V-
L
V
A
A
L
A
L
D
G
T
Y
V
V
V
E
E
--
F
R
P
V
D
A
L
Q
L
V
Q
Q
E
Q
V
T
S
L
F
A
T
P
T
H
L
D
A
L
A
A
A
A
A
H
-----
A
G
SSLKL
D
-------
S
L
R
H
V
T
F
A
G
A
T
--
M
P
D
A
V
L
E
T
V
H
Q
H
---
L
P
G
E
K
V
N
I
Y
G
T
T
E
A
M
N
S
L
Y
M
R
Q
P
-------
K
T
G
T
E
M
A
P
G
-
F
F
-
S
E
V
R
I
V
R
--
I
G
GGVD
E
I
-
V
A
N
G
E
E
G
E
L
I
V
A
A
S
D
S
A
F
V
G
Y
L
N
Q
P
Q
A
T
A
E
K
L
Q
--------
D
G
W
Y
R
T
S
D
V
A
V
W
T
P
E
G
T
V
R
I
L
G
R
V
D
D
M
I
I
S
G
G
E
N
I
H
P
S
E
I
E
R
V
L
G
T
A
P
G
V
T
E
V
V
V
I
G
L
A
D
Q
R
W
G
Q
S
V
T
A
C
V
V
P
R
L
G
E
-
T
-----
L
S
A
D
A
L
D
T
F
C
R
S
S
E
-
L
A
D
F
K
-
R
P
K
R
Y
F
I
L
D
Q
L
P
K
N
A
L
N
K
V
L
R
R
Q
L
---------
8
PsiBlast_PDB
52.18
30%
-6
- C2 -
2QVZ
1
?
X:
[5-498]
------
N
E
M
L
-
R
R
A
A
T
R
A
P
D
H
C
A
L
A
--
V
----
P
A
R
GL
R
L
T
H
A
E
L
R
A
R
V
E
A
V
A
A
R
L
H
A
D
G
L
R
P
Q
Q
R
V
A
V
V
A
P
N
S
A
D
V
V
I
A
I
L
A
L
H
R
L
G
A
V
P
A
L
L
N
P
R
L
K
S
A
E
-
L
A
E
L
I
K
R
G
E
MTAAVIAV--
Q
V
A
D
A
I
---------
F
Q
S
G
S
G
--------
A
------------
R
-------------
I
--
I
F
L
G
D
---------
L
V
---
R
D
G
E
P
----
Y
--
S
--
Y
G
--
P
---
P
I
E
D
P
Q
R
E
P
A
Q
P
A
F
I
F
Y
T
S
---
G
L
P
K
A
AI
I
P
Q
R
A
A
E
S
R
V
L
F
M
-
S
T
Q
V
---
G
L
R
H
G
R
H
N
V
V
L
G
L
M
P
L
Y
H
V
V
G
F
F
--
A
V-
L
V
A
A
L
A
L
D
G
T
Y
V
V
V
E
E
--
F
R
P
V
D
A
L
Q
L
V
Q
Q
E
Q
V
T
S
L
F
A
T
P
T
H
L
D
A
L
A
A
A
A
A
H
-----
A
G
SSLKL
D
-------
S
L
R
H
V
T
F
A
G
A
T
--
M
P
D
A
V
L
E
T
V
H
Q
H
---
L
P
GE
K
V
N
A
Y
G
T
T
E
A
M
N
S
L
Y
M
R
Q
P
-------
K
T
G
T
E
M
A
P
G
-
F
F
-
S
E
V
R
I
V
R
--
I
G
GGVD
E
I
-
V
A
N
G
E
E
G
E
L
I
V
A
A
S
D
S
A
F
V
G
Y
L
N
Q
P
Q
A
T
A
E
K
L
Q
--------
D
G
W
Y
R
T
S
D
V
A
V
W
T
P
E
G
T
V
R
I
L
G
R
V
D
D
M
I
I
S
G
G
E
N
I
H
P
S
E
I
E
R
V
L
G
T
A
P
G
V
T
E
V
V
V
I
G
L
A
D
Q
R
W
G
Q
S
V
T
A
C
V
V
PR
L
G
E
-
T
-----
L
S
A
D
A
L
D
T
F
C
R
S
S
E
-
L
A
D
F
K
-
R
P
K
R
Y
F
I
L
D
Q
L
P
K
N
A
L
N
K
V
L
R
R
Q
L
---------
12
PsiBlast_PDB
51.94
30%
-11
- C2 -
1T5D
2
?
X:
[5-498]
------
N
E
M
L
-
R
R
A
A
T
R
A
P
D
H
C
A
L
A
--
V
----
P
A
R
GL
R
L
T
H
A
E
L
R
A
R
V
E
A
V
A
A
R
L
H
A
D
G
L
R
P
Q
Q
R
V
A
V
V
A
P
N
S
A
D
V
V
I
A
I
L
A
L
H
R
L
G
A
V
P
A
L
L
N
P
R
L
K
S
A
E
-
L
A
E
L
I
K
R
G
E
MTAAVIAV
G
R
Q
V
A
D
A
I
---------
F
Q
S
G
S
G
--------
A
------------
R
-------------
I
--
I
F
L
G
D
---------
L
V
---
R
D
G
E
P
----
Y
--
S
--
Y
G
--
P
---
P
I
E
D
P
Q
R
E
P
A
Q
P
A
F
I
F
Y
T
S
--
T
G
L
P
K
A
AI
I
P
Q
R
A
A
E
S
R
V
L
F
M
-
S
T
Q
V
---
G
L
R
H
G
R
H
N
V
V
L
G
L
M
P
L
Y
H
V
V
G
F
F
--
A
V-
L
V
A
A
L
A
L
D
G
T
Y
V
V
V
E
E
--
F
R
P
V
D
A
L
Q
L
V
Q
Q
E
Q
V
T
S
L
F
A
T
P
T
H
L
D
A
L
A
A
A
A
A
H
-----
A
G
SSLKL
D
-------
S
L
R
H
V
T
F
A
G
A
T
--
M
P
D
A
V
L
E
T
V
H
Q
H
---
L
P
GE
K
V
N
I
Y
G
T
T
E
A
M
N
S
L
Y
M
R
Q
P
-------
K
T
G
T
E
M
A
P
G
-
F
F
-
S
E
V
R
I
V
R
--
I
G
GGVD
E
I
-
V
A
N
G
E
E
G
E
L
I
V
A
A
S
D
S
A
F
V
G
Y
L
N
Q
P
Q
A
T
A
E
K
L
Q
--------
D
G
W
Y
R
T
S
D
V
A
V
W
T
P
E
G
T
V
R
I
L
G
R
V
D
D
M
I
I
S
G
G
E
N
I
H
P
S
E
I
E
R
V
L
G
T
A
P
G
V
T
E
V
V
V
I
G
L
A
D
Q
R
W
G
Q
S
V
T
A
C
V
V
PR
L
G
E
-
T
-----
L
S
A
D
A
L
D
T
F
C
R
S
S
E
-
L
A
D
F
K
-
R
P
K
R
Y
F
I
L
D
Q
L
P
K
N
A
L
N
K
V
L
R
R
Q
L
---------
9
PsiBlast_PDB
51.76
30%
-7
- C2 -
2QW0
1
?
X:
[5-498]
------
N
E
M
L
-
R
R
A
A
T
R
A
P
D
H
C
A
L
A
--
V
----
P
A
R
GL
R
L
T
H
A
E
L
R
A
R
V
E
A
V
A
A
R
L
H
A
D
G
L
R
P
Q
Q
R
V
A
V
V
A
P
N
S
A
D
V
V
I
A
I
L
A
L
H
R
L
G
A
V
P
A
L
L
N
P
R
L
K
S
A
E
-
L
A
E
L
I
K
R
G
E
MTAAVIAV--
Q
V
A
D
A
I
---------
F
Q
S
G
S
G
--------
A
------------
R
-------------
I
--
I
F
L
G
D
---------
L
V
---
R
D
G
E
P
----
Y
--
S
--
Y
G
--
P
---
P
I
E
D
P
Q
R
E
P
A
Q
P
A
F
I
F
Y
T
S
---
G
L
P
K
A
AI
I
P
Q
R
A
A
E
S
R
V
L
F
M
-
S
T
Q
V
---
G
L
R
H
G
R
H
N
V
V
L
G
L
M
P
L
Y
H
V
V
G
F
F
--
A
V-
L
V
A
A
L
A
L
D
G
T
Y
V
V
V
E
E
--
F
R
P
V
D
A
L
Q
L
V
Q
Q
E
Q
V
T
S
L
F
A
T
P
T
H
L
D
A
L
A
A
A
A
A
H
-----
A
G
SSLKL
D
-------
S
L
R
H
V
T
F
A
G
A
T
--
M
P
D
A
V
L
E
T
V
H
Q
H
---
L
P
GE
K
V
N
A
Y
G
T
T
E
A
M
N
S
L
Y
M
R
Q
P
-------
K
T
G
T
E
M
A
P
G
-
F
F
-
S
E
V
R
I
V
R
--
I
G
GGVD
E
I
-
V
A
N
G
E
E
G
E
L
I
V
A
A
S
D
S
A
F
V
G
Y
L
N
Q
P
Q
A
T
A
E
K
L
Q
--------
D
G
W
Y
R
T
S
D
V
A
V
W
T
P
E
G
T
V
R
I
L
G
R
V
D
D
M
I
I
S
G
G
E
N
I
H
P
S
E
I
E
R
V
L
G
T
A
P
G
V
T
E
V
V
V
I
G
L
A
D
Q
R
W
G
Q
S
V
T
A
C
V
V
PR
L
G
E
-
T
-----
L
S
A
D
A
L
D
T
F
C
R
S
S
E
-
L
A
D
F
K
-
R
P
K
R
Y
F
I
L
D
Q
L
P
K
N
A
L
N
K
V
L
R
R
Q
L
---------
71
HHSearch
51.63
27%
-23
- C2 -
4IZ6
2
ENTE_ECOLI
A:
[57-555]
------------------
S
D
S
I
A
V
I
--
D
----
G
E
R
--
Q
L
S
Y
R
E
L
N
Q
A
A
D
N
L
A
C
S
L
R
R
Q
G
I
K
P
G
E
T
A
L
V
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----