@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu33920: (2016-07-27 )
MRKPIIAGNWKMNKTLGEAVSFVEEVKSSIPAADKAEAVVCAPALFLEKLASAVKGTDLKVGAQNMHFEESGAFTGEISPVALKDLGVDYCVIGHSERREMFAETDETVNKKAHAAFKHGIVPIICVGETLEEREAGKTNDLVADQVKKGLAGLSEEQVAASVIAYEPIWAIGTGKSSTAKDANDVCAHIRKTVAESFSQEAADKLRIQYGGSVKPANIKEYMAESDIDGALVGGASLEPQSFVQLLEEGQYE
Atome Classification :
(56 SA)
.........10..---......20.......-.30--.-.......40...-.....50....---....60--.--.......70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190......--.200.........210.......220.......230.......240.......250.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MRK
P
I
I
AGN
W
K
M
N
---
K
T
L
G
E
A
V
S
F
V
E
E
V
K
S
-SIP--A-ADKA
E
A
V
V
C
A
P
A
-
L
F
L
E
K
L
A
S
A
VK---GT
D
L
K
V--G--AQN
M
H
FEESGAFTGEIS
P
V
A
L
K
DLGV
D
Y
C
VIG
H
S
E
R
R
E
M
F
AE
T
D
E
T
V
N
K
K
A
H
A
A
F
KHG
I
V
P
I
I
CVGE
T
L
E
E
REAGKTN
D
L
V
A
D
Q
V
K
K
G
LAGL
S
E
E
Q
V
A
A
S
V
IAYE
P
I
W
A
IGTGKSSTAK
D
A
N
D
V
C
A
H
I
R
K
T
V
A
E
S
F
--
S
Q
--
E
A
A
D
K
L
R
I
Q
YGGSVK
P
A
N
I
K
E
Y
M
A
ESDID
G
A
LVGGASL
E
P
Q
S
F
V
Q
L
L
EEGQYE
104
HHSearch
94.42
69%
-97
- C7 -
2BTM
1
TPIS_GEOSE
A:
[1-251]
-
R
K
P
I
I
A
G
N
W
K
M
N
---
G
T
L
A
E
A
V
Q
F
V
E
D
V
K
G
-
H
V
P
--
P
-
A
D
E
V
I
S
V
V
C
A
P
F
-
L
F
L
D
R
L
V
Q
A
A
D
---
G
T
D
L
K
I
--
G
--
A
Q
T
M
H
F
A
D
Q
G
A
Y
T
G
E
V
S
P
V
M
L
K
D
L
G
V
T
Y
V
I
L
G
H
S
E
R
R
Q
M
F
A
E
T
D
E
T
V
N
K
K
V
L
A
A
F
T
R
G
L
I
P
I
I
C
C
G
E
S
L
E
E
R
E
A
G
Q
T
N
A
V
V
A
S
Q
V
E
K
A
L
A
G
L
T
P
E
Q
V
K
Q
A
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
S
S
T
P
E
D
A
N
S
V
C
G
H
I
R
S
V
V
S
R
L
F
--
G
P
--
E
A
A
E
A
I
R
I
Q
Y
G
G
S
V
K
P
D
N
I
R
D
F
L
A
Q
Q
Q
I
D
G
A
L
V
G
G
A
S
L
E
P
A
S
F
L
Q
L
V
E
A
G
R
H
-
21
PsiBlast_CBE
94.19
68%
-92
- C7 -
2BTM
1
TPIS_GEOSE
B:
[1-251]
-
R
K
P
I
I
A
G
N
W
K
M
N
---
G
T
L
A
E
A
V
Q
F
V
E
D
V
K
G
-
H
V
P
--
P
-
A
D
E
V
I
S
V
V
C
A
P
F
-
L
F
L
D
R
L
V
Q
A
A
D
---
G
T
D
L
K
I
--
G
--
A
Q
T
M
H
F
A
D
Q
G
A
Y
T
G
E
V
S
P
V
M
L
K
D
L
G
V
T
Y
V
I
L
G
H
S
E
R
R
Q
M
F
A
E
T
D
E
T
V
N
K
K
V
L
A
A
F
T
R
G
L
I
P
I
I
C
C
G
E
S
L
E
E
R
E
A
G
Q
T
N
A
V
V
A
S
Q
V
E
K
A
L
A
G
L
T
P
E
Q
V
K
Q
A
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
S
S
T
P
E
D
A
N
S
V
C
G
H
I
R
S
V
V
S
R
L
F
--
G
P
--
E
A
A
E
A
I
R
I
Q
Y
G
G
S
V
K
P
D
N
I
R
D
F
L
A
Q
Q
Q
I
D
G
A
L
V
G
G
A
S
L
E
P
A
S
F
L
Q
L
V
E
A
G
R
H
-
122
Fugue
94.13
68%
-97
- C7 -
2BTM
1
TPIS_GEOSE
A:
[1-250]
-
R
K
P
I
I
A
G
N
W
K
M
N
---
G
T
L
A
E
A
V
Q
F
V
E
D
V
K
G
-
H
V
P
--
P
-
A
D
E
V
I
S
V
V
C
A
P
F
-
L
F
L
D
R
L
V
Q
A
A
D
---
G
T
D
L
K
I
--
G
--
A
Q
T
M
H
F
A
D
Q
G
A
Y
T
G
E
V
S
P
V
M
L
K
D
L
G
V
T
Y
V
I
L
G
H
S
E
R
R
Q
M
F
A
E
T
D
E
T
V
N
K
K
V
L
A
A
F
T
R
G
L
I
P
I
I
C
C
G
E
S
L
E
E
R
E
A
G
Q
T
N
A
V
V
A
S
Q
V
E
K
A
L
A
G
L
T
P
E
Q
V
K
Q
A
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
S
S
T
P
E
D
A
N
S
V
C
G
H
I
R
S
V
V
S
R
L
F
--
G
P
--
E
A
A
E
A
I
R
I
Q
Y
G
G
S
V
K
P
D
N
I
R
D
F
L
A
Q
Q
Q
I
D
G
A
L
V
G
G
A
S
L
E
P
A
S
F
L
Q
L
V
E
A
G
R
--
1
PsiBlast_PDB
94.12
68%
-97
- C7 -
2BTM
1
TPIS_GEOSE
A:
[1-251]
-
R
K
P
I
I
A
G
N
W
K
M
N
---
G
T
L
A
E
A
V
Q
F
V
E
D
V
K
G
-
H
V
P
--
P
-
A
D
E
V
I
S
V
V
C
A
P
F
-
L
F
L
D
R
L
V
Q
A
A
D
---
G
T
D
L
K
I
--
G
--
A
Q
T
M
H
F
A
D
Q
G
A
Y
T
G
E
V
S
P
V
M
L
K
D
L
G
V
T
Y
V
I
L
G
H
S
E
R
R
Q
M
F
A
E
T
D
E
T
V
N
K
K
V
L
A
A
F
T
R
G
L
I
P
I
I
C
C
G
E
S
L
E
E
R
E
A
G
Q
T
N
A
V
V
A
S
Q
V
E
K
A
L
A
G
L
T
P
E
Q
V
K
Q
A
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
S
S
T
P
E
D
A
N
S
V
C
G
H
I
R
S
V
V
S
R
L
F
--
G
P
--
E
A
A
E
A
I
R
I
Q
Y
G
G
S
V
K
P
D
N
I
R
D
F
L
A
Q
Q
Q
I
D
G
A
L
V
G
G
A
S
L
E
P
A
S
F
L
Q
L
V
E
A
G
R
H
-
2
PsiBlast_PDB
92.94
68%
-93
- C7 -
1BTM
1
TPIS_GEOSE
A:
[1-251]
-
R
K
P
I
I
A
G
N
W
K
M
H
---
K
T
L
A
E
A
V
Q
F
V
E
D
V
K
G
-
H
V
P
--
P
-
A
D
E
V
I
S
V
V
C
A
P
F
-
L
F
L
D
R
L
V
Q
A
A
D
---
G
T
D
L
K
I
--
G
--
A
Q
T
M
H
F
A
D
Q
G
A
Y
T
G
E
V
S
P
V
M
L
K
D
L
G
V
T
Y
V
I
L
G
H
S
E
R
R
Q
M
F
A
E
T
D
E
T
V
N
K
K
V
L
A
A
F
T
R
G
L
I
P
I
I
C
C
G
E
S
L
E
E
R
E
A
G
Q
T
N
A
V
V
A
S
Q
V
E
K
A
L
A
G
L
T
P
E
Q
V
K
Q
A
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
S
S
T
P
E
D
A
N
S
V
C
G
H
I
R
S
V
V
S
R
L
F
--
G
P
--
E
A
A
E
A
I
R
I
Q
Y
G
G
S
V
K
P
D
N
I
R
D
F
L
A
Q
Q
Q
I
D
G
P
L
V
G
G
A
S
L
E
P
A
S
F
L
Q
L
V
E
A
G
R
H
-
33
PsiBlast_CBE
92.53
61%
-102
- C7 -
5IBX
1
?
D:
[6-252]
-
R
K
P
F
I
A
G
N
W
K
M
N
---
K
N
P
E
E
A
K
A
F
V
E
A
V
A
S
-
K
L
P
--
S
-
S
D
L
V
E
A
G
I
A
A
P
A
-
L
D
L
T
T
V
L
A
V
A
K
---
G
S
N
L
K
V
--
A
--
A
Q
N
C
Y
F
E
N
A
G
A
F
T
G
E
T
S
P
Q
V
L
K
E
I
G
T
D
Y
V
V
I
G
H
S
E
R
R
D
Y
F
H
E
T
D
E
D
I
N
K
K
A
K
A
I
F
A
N
G
M
L
P
I
I
C
C
G
E
S
L
E
T
Y
E
A
G
K
A
A
E
F
V
G
A
Q
V
S
A
A
L
A
G
L
T
A
E
Q
V
A
A
S
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
S
A
S
Q
D
D
A
Q
K
M
C
K
V
V
R
D
V
V
A
A
D
F
--
G
Q
--
E
V
A
D
K
V
R
V
Q
Y
G
G
S
V
K
P
E
N
V
A
S
Y
M
A
C
P
D
V
D
G
A
L
V
G
G
A
S
L
E
A
E
S
F
L
A
L
L
D
-----
22
PsiBlast_CBE
92.16
68%
-92
- C7 -
1BTM
1
TPIS_GEOSE
B:
[1-251]
-
R
K
P
I
I
A
G
N
W
K
M
H
---
K
T
L
A
E
A
V
Q
F
V
E
D
V
K
G
-
H
V
P
--
P
-
A
D
E
V
I
S
V
V
C
A
P
F
-
L
F
L
D
R
L
V
Q
A
A
D
---
G
T
D
L
K
I
--
G
--
A
Q
T
M
H
F
A
D
Q
G
A
Y
T
G
E
V
S
P
V
M
L
K
D
L
G
V
T
Y
V
I
L
G
H
S
E
R
R
Q
M
F
A
E
T
D
E
T
V
N
K
K
V
L
A
A
F
T
R
G
L
I
P
I
I
C
C
G
E
S
L
E
E
R
E
A
G
Q
T
N
A
V
V
A
S
Q
V
E
K
A
L
A
G
L
T
P
E
Q
V
K
Q
A
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
S
S
T
P
E
D
A
N
S
V
C
G
H
I
R
S
V
V
S
R
L
F
--
G
P
--
E
A
A
E
A
I
R
I
Q
Y
G
G
S
V
K
P
D
N
I
R
D
F
L
A
Q
Q
Q
I
D
G
P
L
V
G
G
A
S
L
E
P
A
S
F
L
Q
L
V
E
A
G
R
H
-
28
PsiBlast_CBE
91.83
61%
-100
- C7 -
5IBX
1
?
G:
[6-252]
-
R
K
P
F
I
A
G
N
W
K
M
N
---
K
N
P
E
E
A
K
A
F
V
E
A
V
A
S
-
K
L
P
--
S
-
S
D
L
V
E
A
G
I
A
A
P
A
-
L
D
L
T
T
V
L
A
V
A
K
---
G
S
N
L
K
V
--
A
--
A
Q
N
C
Y
F
E
N
A
G
A
F
T
G
E
T
S
P
Q
V
L
K
E
I
G
T
D
Y
V
V
I
G
H
S
E
R
R
D
Y
F
H
E
T
D
E
D
I
N
K
K
A
K
A
I
F
A
N
G
M
L
P
I
I
C
C
G
E
S
L
E
T
Y
E
A
G
K
A
A
E
F
V
G
A
Q
V
S
A
A
L
A
G
L
T
A
E
Q
V
A
A
S
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
S
A
S
Q
D
D
A
Q
K
M
C
K
V
V
R
D
V
V
A
A
D
F
--
G
Q
--
E
V
A
D
K
V
R
V
Q
Y
G
G
S
V
K
P
E
N
V
A
S
Y
M
A
C
P
D
V
D
G
A
L
V
G
G
A
S
L
E
A
E
S
F
L
A
L
L
D
-----
9
PsiBlast_PDB
91.38
61%
-101
- C7 -
5IBX
1
?
A:
[6-252]
-
R
K
P
F
I
A
G
N
W
K
M
N
---
K
N
P
E
E
A
K
A
F
V
E
A
V
A
S
-
K
L
P
--
S
-
S
D
L
V
E
A
G
I
A
A
P
A
-
L
D
L
T
T
V
L
A
V
A
K
---
G
S
N
L
K
V
--
A
--
A
Q
N
C
Y
F
E
N
A
G
A
F
T
G
E
T
S
P
Q
V
L
K
E
I
G
T
D
Y
V
V
I
G
H
S
E
R
R
D
Y
F
H
E
T
D
E
D
I
N
K
K
A
K
A
I
F
A
N
G
M
L
P
I
I
C
C
G
E
S
L
E
T
Y
E
A
G
K
A
A
E
F
V
G
A
Q
V
S
A
A
L
A
G
L
T
A
E
Q
V
A
A
S
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
S
A
S
Q
D
D
A
Q
K
M
C
K
V
V
R
D
V
V
A
A
D
F
--
G
Q
--
E
V
A
D
K
V
R
V
Q
Y
G
G
S
V
K
P
E
N
V
A
S
Y
M
A
C
P
D
V
D
G
A
L
V
G
G
A
S
L
E
A
E
S
F
L
A
L
L
D
-----
110
HHSearch
91.35
61%
-100
- C7 -
5IBX
1
?
A:
[5-254]
S
R
K
P
F
I
A
G
N
W
K
M
N
---
K
N
P
E
E
A
K
A
F
V
E
A
V
A
S
-
K
L
P
--
S
-
S
D
L
V
E
A
G
I
A
A
P
A
-
L
D
L
T
T
V
L
A
V
A
K
---
G
S
N
L
K
V
--
A
--
A
Q
N
C
Y
F
E
N
A
G
A
F
T
G
E
T
S
P
Q
V
L
K
E
I
G
T
D
Y
V
V
I
G
H
S
E
R
R
D
Y
F
H
E
T
D
E
D
I
N
K
K
A
K
A
I
F
A
N
G
M
L
P
I
I
C
C
G
E
S
L
E
T
Y
E
A
G
K
A
A
E
F
V
G
A
Q
V
S
A
A
L
A
G
L
T
A
E
Q
V
A
A
S
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
S
A
S
Q
D
D
A
Q
K
M
C
K
V
V
R
D
V
V
A
A
D
F
--
G
Q
--
E
V
A
D
K
V
R
V
Q
Y
G
G
S
V
K
P
E
N
V
A
S
Y
M
A
C
P
D
V
D
G
A
L
V
G
G
A
S
L
E
A
E
S
F
L
A
L
L
D
F
V
---
10
PsiBlast_PDB
91.27
61%
-110
- C7 -
4Y8F
5
TPIS_CLOPE
A:
[4-249]
M
R
T
P
I
I
A
G
N
W
K
M
H
---
Y
T
I
D
E
A
V
K
L
V
E
E
L
K
P
-
L
V
K
--
D
-
A
-
K
C
E
V
V
V
C
P
T
F
-
V
C
L
D
A
V
K
K
A
V
E
---
G
T
N
I
K
V
--
G
--
A
Q
N
M
H
F
E
E
K
G
A
F
T
G
E
I
A
P
R
M
L
E
A
M
N
I
D
Y
V
I
I
G
H
S
E
R
R
E
Y
F
N
E
T
D
E
T
C
N
K
K
V
K
A
A
F
A
H
N
L
T
P
I
L
C
C
G
E
T
L
E
Q
R
E
N
G
T
T
N
D
V
I
K
A
Q
I
T
A
D
L
E
G
L
T
K
E
Q
A
E
K
V
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
T
A
T
S
D
Q
A
N
E
T
I
A
A
I
R
A
M
V
A
E
M
F
--
G
Q
--
E
V
A
D
K
V
R
I
Q
Y
G
G
S
V
K
P
N
T
I
A
E
Q
M
A
K
S
D
I
D
G
A
L
V
G
G
A
S
L
V
A
A
D
F
A
Q
I
V
------
30
PsiBlast_CBE
91.26
61%
-97
- C7 -
5IBX
3
?
C:
[6-252]
-
R
K
P
F
I
A
G
N
W
K
M
N
---
K
N
P
E
E
A
K
A
F
V
E
A
V
A
S
-
K
L
P
--
S
-
S
D
L
V
E
A
G
I
A
A
P
A
-
L
D
L
T
T
V
L
A
V
A
K
---
G
S
N
L
K
V
--
A
--
A
Q
N
C
Y
F
E
N
A
G
A
F
T
G
E
T
S
P
Q
V
L
K
E
I
G
T
D
Y
V
V
I
G
H
S
E
R
R
D
Y
F
H
E
T
D
E
D
I
N
K
K
A
K
A
I
F
A
N
G
M
L
P
I
I
C
C
G
E
S
L
E
T
Y
E
A
G
K
A
A
E
F
V
G
A
Q
V
S
A
A
L
A
G
L
T
A
E
Q
V
A
A
S
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
S
A
S
Q
D
D
A
Q
K
M
C
K
V
V
R
D
V
V
A
A
D
F
--
G
Q
--
E
V
A
D
K
V
R
V
Q
Y
G
G
S
V
K
P
E
N
V
A
S
Y
M
A
C
P
D
V
D
G
A
L
V
G
G
A
S
L
E
A
E
S
F
L
A
L
L
D
-----
105
HHSearch
91.05
61%
-107
- C7 -
4Y8F
5
TPIS_CLOPE
A:
[4-250]
M
R
T
P
I
I
A
G
N
W
K
M
H
---
Y
T
I
D
E
A
V
K
L
V
E
E
L
K
P
-
L
V
---
K
-
D
A
K
C
E
V
V
V
C
P
T
F
-
V
C
L
D
A
V
K
K
A
V
E
---
G
T
N
I
K
V
--
G
--
A
Q
N
M
H
F
E
E
K
G
A
F
T
G
E
I
A
P
R
M
L
E
A
M
N
I
D
Y
V
I
I
G
H
S
E
R
R
E
Y
F
N
E
T
D
E
T
C
N
K
K
V
K
A
A
F
A
H
N
L
T
P
I
L
C
C
G
E
T
L
E
Q
R
E
N
G
T
T
N
D
V
I
K
A
Q
I
T
A
D
L
E
G
L
T
K
E
Q
A
E
K
V
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
T
A
T
S
D
Q
A
N
E
T
I
A
A
I
R
A
M
V
A
E
M
F
--
G
Q
--
E
V
A
D
K
V
R
I
Q
Y
G
G
S
V
K
P
N
T
I
A
E
Q
M
A
K
S
D
I
D
G
A
L
V
G
G
A
S
L
V
A
A
D
F
A
Q
I
V
N
-----
29
PsiBlast_CBE
90.96
61%
-98
- C7 -
5IBX
2
?
F:
[6-252]
-
R
K
P
F
I
A
G
N
W
K
M
N
---
K
N
P
E
E
A
K
A
F
V
E
A
V
A
S
-
K
L
P
--
S
-
S
D
L
V
E
A
G
I
A
A
P
A
-
L
D
L
T
T
V
L
A
V
A
K
---
G
S
N
L
K
V
--
A
--
A
Q
N
C
Y
F
E
N
A
G
A
F
T
G
E
T
S
P
Q
V
L
K
E
I
G
T
D
Y
V
V
I
G
H
S
E
R
R
D
Y
F
H
E
T
D
E
D
I
N
K
K
A
K
A
I
F
A
N
G
M
L
P
I
I
C
C
G
E
S
L
E
T
Y
E
A
G
K
A
A
E
F
V
G
A
Q
V
S
A
A
L
A
G
L
T
A
E
Q
V
A
A
S
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
S
A
S
Q
D
D
A
Q
K
M
C
K
V
V
R
D
V
V
A
A
D
F
--
G
Q
--
E
V
A
D
K
V
R
V
Q
Y
G
G
S
V
K
P
E
N
V
A
S
Y
M
A
C
P
D
V
D
G
A
L
V
G
G
A
S
L
E
A
E
S
F
L
A
L
L
D
-----
32
PsiBlast_CBE
90.67
61%
-102
- C7 -
5IBX
2
?
E:
[6-252]
-
R
K
P
F
I
A
G
N
W
K
M
N
---
K
N
P
E
E
A
K
A
F
V
E
A
V
A
S
-
K
L
P
--
S
-
S
D
L
V
E
A
G
I
A
A
P
A
-
L
D
L
T
T
V
L
A
V
A
K
---
G
S
N
L
K
V
--
A
--
A
Q
N
C
Y
F
E
N
A
G
A
F
T
G
E
T
S
P
Q
V
L
K
E
I
G
T
D
Y
V
V
I
G
H
S
E
R
R
D
Y
F
H
E
T
D
E
D
I
N
K
K
A
K
A
I
F
A
N
G
M
L
P
I
I
C
C
G
E
S
L
E
T
Y
E
A
G
K
A
A
E
F
V
G
A
Q
V
S
A
A
L
A
G
L
T
A
E
Q
V
A
A
S
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
S
A
S
Q
D
D
A
Q
K
M
C
K
V
V
R
D
V
V
A
A
D
F
--
G
Q
--
E
V
A
D
K
V
R
V
Q
Y
G
G
S
V
K
P
E
N
V
A
S
Y
M
A
C
P
D
V
D
G
A
L
V
G
G
A
S
L
E
A
E
S
F
L
A
L
L
D
-----
34
PsiBlast_CBE
89.52
61%
-95
- C7 -
5IBX
2
?
B:
[6-252]
-
R
K
P
F
I
A
G
N
W
K
M
N
---
K
N
P
E
E
A
K
A
F
V
E
A
V
A
S
-
K
L
P
--
S
-
S
D
L
V
E
A
G
I
A
A
P
A
-
L
D
L
T
T
V
L
A
V
A
K
---
G
S
N
L
K
V
--
A
--
A
Q
N
C
Y
F
E
N
A
G
A
F
T
G
E
T
S
P
Q
V
L
K
E
I
G
T
D
Y
V
V
I
G
H
S
E
R
R
D
Y
F
H
E
T
D
E
D
I
N
K
K
A
K
A
I
F
A
N
G
M
L
P
I
I
C
C
G
E
S
L
E
T
Y
E
A
G
K
A
A
E
F
V
G
A
Q
V
S
A
A
L
A
G
L
T
A
E
Q
V
A
A
S
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
S
A
S
Q
D
D
A
Q
K
M
C
K
V
V
R
D
V
V
A
A
D
F
--
G
Q
--
E
V
A
D
K
V
R
V
Q
Y
G
G
S
V
K
P
E
N
V
A
S
Y
M
A
C
P
D
V
D
G
A
L
V
G
G
A
S
L
E
A
E
S
F
L
A
L
L
D
-----
106
HHSearch
89.38
48%
-108
- C7 -
1B9B
1
PGKT_THEMA
A:
[2-251]
T
R
K
L
I
L
A
G
N
W
K
M
H
---
K
T
I
S
E
A
K
K
F
V
S
L
L
V
N
-
E
L
H
--
D
-
V
K
E
F
E
I
V
V
C
P
P
F
-
T
A
L
S
E
V
G
E
I
L
S
---
G
R
N
I
K
L
--
G
--
A
Q
N
V
F
Y
E
D
Q
G
A
F
T
G
E
I
S
P
L
M
L
Q
E
I
G
V
E
Y
V
I
V
G
H
S
E
R
R
R
I
F
K
E
D
D
E
F
I
N
R
K
V
K
A
V
L
E
K
G
M
T
P
I
L
C
V
G
E
T
L
E
E
R
E
K
G
L
T
F
C
V
V
E
K
Q
V
R
E
G
F
Y
G
L
D
K
E
E
A
K
R
V
V
I
A
Y
E
P
V
W
A
I
G
T
G
R
V
A
T
P
Q
Q
A
Q
E
V
H
A
F
I
R
K
L
L
S
E
M
Y
--
D
E
--
E
T
A
G
S
I
R
I
L
Y
G
G
S
I
K
P
D
N
F
L
G
L
I
V
Q
K
D
I
D
G
G
L
V
G
G
A
S
L
K
E
-
S
F
I
E
L
A
R
I
M
R
--
11
PsiBlast_PDB
87.99
49%
-108
- C7 -
1B9B
1
PGKT_THEMA
A:
[3-246]
-
R
K
L
I
L
A
G
N
W
K
M
H
---
K
T
I
S
E
A
K
K
F
V
S
L
L
V
N
-
E
L
H
--
D
-
V
K
E
F
E
I
V
V
C
P
P
F
-
T
A
L
S
E
V
G
E
I
L
S
---
G
R
N
I
K
L
--
G
--
A
Q
N
V
F
Y
E
D
Q
G
A
F
T
G
E
I
S
P
L
M
L
Q
E
I
G
V
E
Y
V
I
V
G
H
S
E
R
R
R
I
F
K
E
D
D
E
F
I
N
R
K
V
K
A
V
L
E
K
G
M
T
P
I
L
C
V
G
E
T
L
E
E
R
E
K
G
L
T
F
C
V
V
E
K
Q
V
R
E
G
F
Y
G
L
D
K
E
E
A
K
R
V
V
I
A
Y
E
P
V
W
A
I
G
T
G
R
V
A
T
P
Q
Q
A
Q
E
V
H
A
F
I
R
K
L
L
S
E
M
Y
--
D
E
--
E
T
A
G
S
I
R
I
L
Y
G
G
S
I
K
P
D
N
F
L
G
L
I
V
Q
K
D
I
D
G
G
L
V
G
G
A
S
L
K
-
E
S
F
I
E
L
-------
31
PsiBlast_CBE
87.47
61%
-95
- C7 -
5IBX
1
?
H:
[6-252]
-
R
K
P
F
I
A
G
N
W
K
M
N
---
K
N
P
E
E
A
K
A
F
V
E
A
V
A
S
-
K
L
P
--
S
-
S
D
L
V
E
A
G
I
A
A
P
A
-
L
D
L
T
T
V
L
A
V
A
K
---
G
S
N
L
K
V
--
A
--
A
Q
N
C
Y
F
E
N
A
G
A
F
T
G
E
T
S
P
Q
V
L
K
E
I
G
T
D
Y
V
V
I
G
H
S
E
R
R
D
Y
F
H
E
T
D
E
D
I
N
K
K
A
K
A
I
F
A
N
G
M
L
P
I
I
C
C
G
E
S
L
E
T
Y
E
A
G
K
A
A
E
F
V
G
A
Q
V
S
A
A
L
A
G
L
T
A
E
Q
V
A
A
S
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
S
A
S
Q
D
D
A
Q
K
M
C
K
V
V
R
D
V
V
A
A
D
F
--
G
Q
--
E
V
A
D
K
V
R
V
Q
Y
G
G
S
V
K
P
E
N
V
A
S
Y
M
A
-
P
D
V
D
G
A
L
V
G
G
A
S
L
E
A
E
S
F
L
A
L
L
D
-----
6
PsiBlast_PDB
85.79
66%
-13
- C7 -
3UWW
3
TPIS_STAAR
A:
[9-258]
M
R
T
P
I
I
A
G
N
W
K
M
N
---
K
T
V
Q
E
A
K
D
F
V
N
A
L
-
P
-
T
L
P
--
D
-
S
K
E
V
E
S
V
I
C
A
P
A
-
I
Q
L
D
A
L
T
T
A
V
K
E
GK
A
Q
G
L
E
I
--
G
--
A
Q
N
T
Y
F
E
D
N
G
A
F
T
G
E
T
S
P
V
A
L
A
D
L
G
V
K
Y
V
V
I
G
H
S
E
R
R
E
L
F
H
E
T
D
E
E
I
N
K
K
A
H
A
I
F
K
H
G
M
T
P
I
I
C
V
G
E
T
D
E
E
R
E
S
G
K
A
N
D
V
V
G
E
Q
V
K
K
A
V
A
G
L
S
E
D
Q
L
K
S
V
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
S
S
T
S
E
D
A
N
E
M
C
A
F
V
R
Q
T
I
A
D
L
S
--
S
K
--
E
V
S
E
A
T
R
I
Q
Y
G
G
S
V
K
P
N
N
I
K
E
Y
M
A
Q
T
D
I
D
G
A
L
V
G
G
A
S
L
K
V
E
D
F
V
Q
L
L
E
-----
5
PsiBlast_PDB
85.59
66%
-13
- C7 -
3UWV
5
TPIS_STAAR
A:
[9-258]
M
R
T
P
I
I
A
G
N
W
K
M
N
---
K
T
V
Q
E
A
K
D
F
V
N
A
L
-
P
-
T
L
P
--
D
-
S
K
E
V
E
S
V
I
C
A
P
A
-
I
Q
L
D
A
L
T
T
A
V
K
E
GK
A
Q
G
L
E
I
--
G
--
A
Q
N
T
Y
F
E
D
N
G
A
F
T
G
E
T
S
P
V
A
L
A
D
L
G
V
K
Y
V
V
I
G
H
S
E
R
R
E
L
F
H
E
T
D
E
E
I
N
K
K
A
H
A
I
F
K
H
G
M
T
P
I
I
C
V
G
E
T
D
E
E
R
E
S
G
K
A
N
D
V
V
G
E
Q
V
K
K
A
V
A
G
L
S
E
D
Q
L
K
S
V
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
S
S
T
S
E
D
A
N
E
M
C
A
F
V
R
Q
T
I
A
D
L
S
--
S
K
--
E
V
S
E
A
T
R
I
Q
Y
G
G
S
V
K
P
N
N
I
K
E
Y
M
A
Q
T
D
I
D
G
A
L
V
G
G
A
S
L
K
V
E
D
F
V
Q
L
L
E
-----
26
PsiBlast_CBE
85.56
66%
-13
- C7 -
3UWV
4
TPIS_STAAR
B:
[9-258]
M
R
T
P
I
I
A
G
N
W
K
M
N
---
K
T
V
Q
E
A
K
D
F
V
N
A
L
-
P
-
T
L
P
--
D
-
S
K
E
V
E
S
V
I
C
A
P
A
-
I
Q
L
D
A
L
T
T
A
V
K
E
GK
A
Q
G
L
E
I
--
G
--
A
Q
N
T
Y
F
E
D
N
G
A
F
T
G
E
T
S
P
V
A
L
A
D
L
G
V
K
Y
V
V
I
G
H
S
E
R
R
E
L
F
H
E
T
D
E
E
I
N
K
K
A
H
A
I
F
K
H
G
M
T
P
I
I
C
V
G
E
T
D
E
E
R
E
S
G
K
A
N
D
V
V
G
E
Q
V
K
K
A
V
A
G
L
S
E
D
Q
L
K
S
V
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
S
S
T
S
E
D
A
N
E
M
C
A
F
V
R
Q
T
I
A
D
L
S
--
S
K
--
E
V
S
E
A
T
R
I
Q
Y
G
G
S
V
K
P
N
N
I
K
E
Y
M
A
Q
T
D
I
D
G
A
L
V
G
G
A
S
L
K
V
E
D
F
V
Q
L
L
E
-----
27
PsiBlast_CBE
84.82
66%
-7
- C7 -
3UWU
1
TPIS_STAAR
B:
[9-258]
M
R
T
P
I
I
A
G
N
W
K
M
N
---
K
T
V
Q
E
A
K
D
F
V
N
A
L
-
P
-
T
L
P
--
D
-
S
K
E
V
E
S
V
I
C
A
P
A
-
I
Q
L
D
A
L
T
T
A
V
K
EGK
A
Q
G
L
E
I
--
G
--
A
Q
N
T
Y
F
E
D
N
G
A
F
T
G
E
T
S
P
V
A
L
A
D
L
G
V
K
Y
V
V
I
G
H
S
E
R
R
E
L
F
H
E
T
D
E
E
I
N
K
K
A
H
A
I
F
K
H
G
M
T
P
I
I
C
V
G
E
T
D
E
E
R
E
S
G
K
A
N
D
V
V
G
E
Q
V
K
K
A
V
A
G
L
S
E
D
Q
L
K
S
V
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
S
S
T
S
E
D
A
N
E
M
C
A
F
V
R
Q
T
I
A
D
L
S
--
S
K
--
E
V
S
E
A
T
R
I
Q
Y
G
G
S
V
K
P
N
N
I
K
E
Y
M
A
Q
T
D
I
D
G
A
L
V
G
G
A
S
L
K
V
E
D
F
V
Q
L
L
E
-----
23
PsiBlast_CBE
84.65
66%
-12
- C7 -
3M9Y
3
TPIS_STAAR
B:
[2-251]
M
R
T
P
I
I
A
G
N
W
K
M
N
---
K
T
V
Q
E
A
K
D
F
V
N
A
L
-
P
-
T
L
P
--
D
-
S
K
E
V
E
S
V
I
C
A
P
A
-
I
Q
L
D
A
L
T
T
A
V
K
E
GK
A
Q
G
L
E
I
--
G
--
A
Q
N
T
Y
F
E
D
N
G
A
F
T
G
E
T
S
P
V
A
L
A
D
L
G
V
K
Y
V
V
I
G
H
S
E
R
R
E
L
F
H
E
T
D
E
E
I
N
K
K
A
H
A
I
F
K
H
G
M
T
P
I
I
C
V
G
E
T
D
E
E
R
E
S
G
K
A
N
D
V
V
G
E
Q
V
K
K
A
V
A
G
L
S
E
D
Q
L
K
S
V
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
S
S
T
S
E
D
A
N
E
M
C
A
F
V
R
Q
T
I
A
D
L
S
--
S
K
--
E
V
S
E
A
T
R
I
Q
Y
G
G
S
V
K
P
N
N
I
K
E
Y
M
A
Q
T
D
I
D
G
A
L
V
G
G
A
S
L
K
V
E
D
F
V
Q
L
L
E
-----
8
PsiBlast_PDB
84.62
66%
-11
- C7 -
3UWZ
1
TPIS_STAAR
A:
[9-258]
M
R
T
P
I
I
A
G
N
W
K
M
N
---
K
T
V
Q
E
A
K
D
F
V
N
A
L
-
P
-
T
L
P
--
D
-
S
K
E
V
E
S
V
I
C
A
P
A
-
I
Q
L
D
A
L
T
T
A
V
K
E
GK
A
Q
G
L
E
I
--
G
--
A
Q
N
T
Y
F
E
D
N
G
A
F
T
G
E
T
S
P
V
A
L
A
D
L
G
V
K
Y
V
V
I
G
H
S
E
R
R
E
L
F
H
E
T
D
E
E
I
N
K
K
A
H
A
I
F
K
H
G
M
T
P
I
I
C
V
G
E
T
D
E
E
R
E
S
G
K
A
N
D
V
V
G
E
Q
V
K
K
A
V
A
G
L
S
E
D
Q
L
K
S
V
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
S
S
T
S
E
D
A
N
E
M
C
A
F
V
R
Q
T
I
A
D
L
S
--
S
K
--
E
V
S
E
A
T
R
I
Q
Y
G
G
S
V
K
P
N
N
I
K
E
Y
M
A
Q
T
D
I
D
G
A
L
V
G
G
A
S
L
K
V
E
D
F
V
Q
L
L
E
-----
4
PsiBlast_PDB
84.43
66%
-7
- C7 -
3UWU
2
TPIS_STAAR
A:
[9-258]
M
R
T
P
I
I
A
G
N
W
K
M
N
---
K
T
V
Q
E
A
K
D
F
V
N
A
L
-
P
-
T
L
P
--
D
-
S
K
E
V
E
S
V
I
C
A
P
A
-
I
Q
L
D
A
L
T
T
A
V
K
E
GK
A
Q
G
L
E
I
--
G
--
A
Q
N
T
Y
F
E
D
N
G
A
F
T
G
E
T
S
P
V
A
L
A
D
L
G
V
K
Y
V
V
I
G
H
S
E
R
R
E
L
F
H
E
T
D
E
E
I
N
K
K
A
H
A
I
F
K
H
G
M
T
P
I
I
C
V
G
E
T
D
E
E
R
E
S
G
K
A
N
D
V
V
G
E
Q
V
K
K
A
V
A
G
L
S
E
D
Q
L
K
S
V
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
S
S
T
S
E
D
A
N
E
M
C
A
F
V
R
Q
T
I
A
D
L
S
--
S
K
--
E
V
S
E
A
T
R
I
Q
Y
G
G
S
V
K
P
N
N
I
K
E
Y
M
A
Q
T
D
I
D
G
A
L
V
G
G
A
S
L
K
V
E
D
F
V
Q
L
L
E
-----
25
PsiBlast_CBE
83.36
66%
-6
- C7 -
3UWW
3
TPIS_STAAR
B:
[10-258]
-
R
T
P
I
I
A
G
N
W
K
M
N
---
K
T
V
Q
E
A
K
D
F
V
N
A
L
-
P
-
T
L
P
--
D
-
S
K
E
V
E
S
V
I
C
A
P
A
-
I
Q
L
D
A
L
T
T
A
V
K
E
GK
A
Q
G
L
E
I
--
G
--
A
Q
N
T
Y
F
E
D
N
G
A
F
T
G
E
T
S
P
V
A
L
A
D
L
G
V
K
Y
V
V
I
G
H
S
E
R
R
E
L
F
H
E
T
D
E
E
I
N
K
K
A
H
A
I
F
K
H
G
M
T
P
I
I
C
V
G
E
T
D
E
E
R
E
S
G
K
A
N
D
V
V
G
E
Q
V
K
K
A
V
A
G
L
S
E
D
Q
L
K
S
V
V
I
A
Y
E
P
I
W
A
I
G
T
G
K
S
S
T
S
E
D
A
N
E
M
C
A
F
V
R
Q
T
I
A
D
L
S
--
S
K
--
E
V
S
E
A
T
R
I
Q
Y
G
G
S
V
K
P
N
N
I
K
E
Y
M
A
Q
T
D
I
D
G
A
L
V
G
G
A
S
L
K
V
E
D
F
V
Q
L
L
E
-----
116
HHSearch
82.89
40%
-98
- C7 -
2VXN
7
TPIS_LEIME
A:
[4-250]
K
P
Q
P
I
A
A
A
N
W
K
C
N
---
G
T
T
A
S
I
E
K
L
V
Q
V
F
N
E
-
H
T
---
I
-
S
H
D
V
Q
C
V
V
A
P
T
F
-
V
H
I
P
L
V
Q
A
K
L
R
---
N
P
K
Y
V
I
--
S
--
A
Q
N
A
I
-
A
K
S
G
A
F
T
G
E
V
S
M
P
I
L
K
D
I
G
V
H
W
V
I
L
G
H
S
E
R
R
T
Y
Y
G
E
T
D
E
I
V
A
Q
K
V
S
E
A
C
K
Q
G
F
M
V
I
A
C
I
G
E
T
L
Q
Q
R
E
A
N
Q
T
A
K
V
V
L
S
Q
T
S
A
I
A
A
K
L
T
K
D
A
W
N
Q
V
V
L
A
Y
E
P
V
W
A
I
G
T
G
K
V
A
T
P
E
Q
A
Q
E
V
H
L
L
L
R
K
W
V
S
E
N
I
--
G
T
--
D
V
A
A
K
L
R
I
L
Y
G
G
S
V
N
A
A
N
A
A
T
L
Y
A
K
P
D
I
N
G
F
L
V
G
G
A
S
L
K
P
E
-
F
R
D
I
I
D
A
T
---
24
PsiBlast_CBE
82.67
66%
-13
- C7 -
3UWZ
2
TPIS_STAAR
B:
[9-258]
M
R
T
P
I
I
A
G
N
W
K
M
N
---
K
T
V
Q
E
A
K
D
F
V
N
A
L
-
P
-
T
L
P
--
D
-
S
K
E
V
E
S
V
I
C
A
P
A
-
I
Q
L
D
A
L
T
T
A
V
K
E
GK
A
Q
G
L
E
I
--
G
--
A
Q
N
T
Y
F
E
D
N
G
A
F
T
G
E
T
S
P
V
A
L
A
D
L
G
V
K
Y
V
V
I
G
H
S
E
R
R
E
L
F
H
E
T
D
E
E
I
N
K
K
A
H
A
I
F
K
H
G
M
T
P
I
I
C
V
G
E
T
D
E
E
R
E
S
G
K
A
N
D
V
V
G
E
Q
V
K
K
A
V
A
G
L
S
E
D
Q
L
K
S
V
V
I
A
Y
E
P
I
W
A
I
---
K
S
S
T
S
E
D
A
N
E
M
C
A
F
V
R
Q
T
I
A
D
L
S
--
S
K
--
E
V
S
E
A
T
R
I
Q
Y
G
G
S
V
K
P
N
N
I
K
E
Y
M
A
Q
T
D
I
D
G
A
L
V
G
G
A
S
L
K
V
E
D
F
V
Q
L
L
E
-----
112
HHSearch
80.76
39%
-111
- C7 -
2J27
1
TPIS_TRYBB
A:
[3-249]
K
P
Q
P
I
A
A
A
N
W
K
C
N
---
G
S
Q
Q
S
L
S
E
L
I
D
L
F
N
S
-
T
S
---
I
-
N
H
D
V
Q
C
V
V
A
S
T
F
-
V
H
L
A
M
T
K
E
R
L
S
---
H
P
K
F
V
I
--
A
--
A
Q
N
A
I
-
A
K
S
G
A
F
T
G
E
V
S
L
P
I
L
K
D
F
G
V
N
W
I
V
L
G
H
S
E
R
R
A
Y
Y
G
E
T
N
E
I
V
A
D
K
V
A
A
A
V
A
S
G
F
M
V
I
A
C
I
G
E
T
L
Q
E
R
E
S
G
R
T
A
V
V
V
L
T
Q
I
A
A
I
A
K
K
L
K
K
A
D
W
A
K
V
V
I
A
Y
E
A
V
W
A
I
G
T
G
K
V
A
T
P
Q
Q
A
Q
E
A
H
A
L
I
R
S
W
V
S
S
K
I
--
G
A
--
D
V
A
G
E
L
R
I
L
Y
G
G
S
V
N
G
K
N
A
R
T
L
Y
Q
Q
R
D
V
N
G
F
L
V
G
G
A
S
L
K
P
E
-
F
V
D
I
I
K
A
T
---
113
HHSearch
79.04
37%
-100
- C7 -
4MKN
6
?
A:
[18-265]
S
A
K
F
F
V
G
G
N
W
K
C
N
---
G
S
V
A
N
V
A
K
L
V
D
E
L
N
A
-
G
T
---
I
-
P
R
G
V
D
V
V
V
A
P
P
F
-
I
Y
I
D
Y
V
M
Q
H
L
D
---
R
D
K
Y
Q
L
--
S
--
A
Q
N
A
W
I
G
G
N
G
A
F
T
G
E
V
S
A
E
Q
L
T
D
F
G
V
P
W
V
I
L
G
H
S
E
R
R
S
L
F
G
E
S
N
E
V
V
A
K
K
T
S
H
A
L
A
A
G
L
G
V
I
A
C
I
G
E
T
L
E
Q
R
N
S
G
S
V
F
K
V
L
D
A
Q
M
D
A
L
V
D
E
V
--
K
D
W
T
K
V
V
L
A
Y
E
P
V
W
A
I
G
T
G
V
V
A
S
P
E
Q
A
Q
E
V
H
A
Y
L
R
Q
Y
C
A
K
K
L
--
G
A
--
A
V
A
D
K
L
R
I
I
Y
G
G
S
V
S
D
T
N
C
K
D
L
S
K
Q
E
D
I
D
G
F
L
V
G
G
A
S
L
K
G
A
A
F
V
T
I
C
N
A
A
G
--
103
HHSearch
78.16
40%
-99
- C7 -
4MVA
4
?
A:
[25-274]
M
R
H
P
L
V
M
G
N
W
K
L
N
---
G
S
R
H
M
V
H
E
L
V
S
N
L
R
K
-
E
L
A
--
G
-
V
A
G
C
A
V
A
I
A
P
P
E
-
M
Y
I
D
M
A
K
R
E
A
E
---
G
S
H
I
M
L
--
G
--
A
Q
N
V
D
L
N
L
S
G
A
F
T
G
E
T
S
A
A
M
L
K
D
I
G
A
Q
Y
I
I
I
G
H
S
E
R
R
T
Y
H
K
E
S
D
E
L
I
A
K
K
F
A
V
L
K
E
Q
G
L
T
P
V
L
C
I
G
E
T
E
A
E
N
E
A
G
K
T
E
E
V
C
A
R
Q
I
D
A
V
L
K
T
Q
G
A
A
A
F
E
G
A
V
I
A
Y
E
P
V
W
A
I
G
T
G
K
S
A
T
P
A
Q
A
Q
A
V
H
K
F
I
R
D
H
I
A
K
V
---
D
A
--
N
I
A
E
Q
V
I
I
Q
Y
G
G
S
V
N
A
S
N
A
A
E
L
F
A
Q
P
D
I
D
G
A
L
V
G
G
A
S
L
K
A
D
A
F
A
V
I
V
K
A
A
E
--
72
PsiBlast_CBE
77.97
39%
-104
- C7 -
4MVA
4
?
A:
[25-271]
M
R
H
P
L
V
M
G
N
W
K
L
N
---
G
S
R
H
M
V
H
E
L
V
S
N
L
R
K
-
E
L
A
--
G
-
V
A
G
C
A
V
A
I
A
P
P
E
-
M
Y
I
D
M
A
K
R
E
A
E
---
G
S
H
I
M
L
--
G
--
A
Q
N
V
D
L
N
L
S
G
A
F
T
G
E
T
S
A
A
M
L
K
D
I
G
A
Q
Y
I
I
I
G
H
S
E
R
R
T
Y
H
K
E
S
D
E
L
I
A
K
K
F
A
V
L
K
E
Q
G
L
T
P
V
L
C
I
G
E
T
E
A
E
N
E
A
G
K
T
E
E
V
C
A
R
Q
I
D
A
V
L
K
T
Q
G
A
A
A
F
E
G
A
V
I
A
Y
E
P
V
W
A
I
G
T
G
K
S
A
T
P
A
Q
A
Q
A
V
H
K
F
I
R
D
H
I
A
K
-
V
--
D
A
--
N
I
A
E
Q
V
I
I
Q
Y
G
G
S
V
N
A
S
N
A
A
E
L
F
A
Q
P
D
I
D
G
A
L
V
G
G
A
S
L
K
A
D
A
F
A
V
I
V
K
-----
36
PsiBlast_CBE
77.04
45%
-12
- C7 -
3GVG
2
TPIS_MYCTU
B:
[25-273]
-
R
K
P
L
I
A
G
N
W
K
M
N
---
L
N
H
Y
E
A
I
A
L
V
Q
K
I
A
F
-
S
L
P
DK
Y
-
Y
D
R
V
D
V
A
V
I
P
P
F
-
T
D
L
R
S
V
Q
T
L
V
D
---
G
D
K
L
R
L
TY
G
--
A
Q
D
L
S
P
H
D
S
G
A
Y
T
G
D
V
S
G
A
F
L
A
K
L
G
C
S
Y
V
V
V
G
H
S
E
R
R
T
Y
H
N
E
D
D
A
L
V
A
A
K
A
A
T
A
L
K
H
G
L
T
P
I
V
C
I
G
E
H
L
D
V
R
E
A
G
N
H
V
A
H
N
I
E
Q
L
R
G
S
L
A
G
L
L
A
E
Q
I
G
S
V
V
I
A
Y
E
P
V
W
A
I
G
T
G
R
V
A
S
A
A
D
A
Q
E
V
C
A
A
I
R
K
E
L
A
S
L
A
--
S
P
--
R
I
A
D
T
V
R
V
L
Y
G
G
S
V
N
A
K
N
V
G
D
I
V
A
Q
D
D
V
D
G
G
L
V
G
G
A
S
L
D
G
E
H
F
A
T
L
-------
71
PsiBlast_CBE
76.92
39%
-107
- C7 -
4MVA
3
?
B:
[25-271]
M
R
H
P
L
V
M
G
N
W
K
L
N
---
G
S
R
H
M
V
H
E
L
V
S
N
L
R
K
-
E
L
A
--
G
-
V
A
G
C
A
V
A
I
A
P
P
E
-
M
Y
I
D
M
A
K
R
E
A
E
---
G
S
H
I
M
L
--
G
--
A
Q
N
V
D
L
N
L
S
G
A
F
T
G
E
T
S
A
A
M
L
K
D
I
G
A
Q
Y
I
I
I
G
H
S
E
R
R
T
Y
H
K
E
S
D
E
L
I
A
K
K
F
A
V
L
K
E
Q
G
L
T
P
V
L
C
I
G
E
T
E
A
E
N
E
A
G
K
T
E
E
V
C
A
R
Q
I
D
A
V
L
K
T
Q
G
A
A
A
F
E
G
A
V
I
A
Y
E
P
V
W
A
I
G
T
G
K
S
A
T
P
A
Q
A
Q
A
V
H
K
F
I
R
D
H
I
A
K
-
V
--
D
A
--
N
I
A
E
Q
V
I
I
Q
Y
G
G
S
V
N
A
S
N
A
A
E
L
F
A
Q
P
D
I
D
G
A
L
V
G
G
A
S
L
K
A
D
A
F
A
V
I
V
K
-----
13
PsiBlast_PDB
76.62
45%
-12
- C7 -
3GVG
1
TPIS_MYCTU
A:
[25-273]
-
R
K
P
L
I
A
G
N
W
K
M
N
---
L
N
H
Y
E
A
I
A
L
V
Q
K
I
A
F
-
S
L
P
D
K
Y
-
Y
D
R
V
D
V
A
V
I
P
P
F
-
T
D
L
R
S
V
Q
T
L
V
D
---
G
D
K
L
R
L
T
Y
G
--
A
Q
D
L
S
P
H
D
S
G
A
Y
T
G
D
V
S
G
A
F
L
A
K
L
G
C
S
Y
V
V
V
G
H
S
E
R
R
T
Y
H
N
E
D
D
A
L
V
A
A
K
A
A
T
A
L
K
H
G
L
T
P
I
V
C
I
G
E
H
L
D
V
R
E
A
G
N
H
V
A
H
N
I
E
Q
L
R
G
S
L
A
G
L
L
A
E
Q
I
G
S
V
V
I
A
Y
E
P
V
W
A
I
G
T
G
R
V
A
S
A
A
D
A
Q
E
V
C
A
A
I
R
K
E
L
A
S
L
A
--
S
P
--
R
I
A
D
T
V
R
V
L
Y
G
G
S
V
N
A
K
N
V
G
D
I
V
A
Q
D
D
V
D
G
G
L
V
G
G
A
S
L
D
G
E
H
F
A
T
L
-------
15
PsiBlast_PDB
75.04
45%
-9
- C7 -
3TAO
2
TPIS_MYCTU
A:
[3-251]
-
R
K
P
L
I
A
G
N
W
K
M
N
---
L
N
H
Y
E
A
I
A
L
V
Q
K
I
A
F
-
S
L
P
D
K
Y
-
Y
D
R
V
D
V
A
V
I
P
P
F
-
T
D
L
R
S
V
Q
T
L
V
D
---
G
D
K
L
R
L
T
Y
G
--
A
Q
D
L
S
P
H
D
S
G
A
Y
T
G
D
V
S
G
A
F
L
A
K
L
G
C
S
Y
V
V
V
G
H
S
E
R
R
T
Y
H
N
E
D
D
A
L
V
A
A
K
A
A
T
A
L
K
H
G
L
T
P
I
V
C
I
G
E
H
L
D
V
R
E
A
G
N
H
V
A
H
N
I
E
Q
L
R
G
S
L
A
G
L
L
A
E
Q
I
G
S
V
V
I
A
Y
E
P
V
W
A
I
G
T
G
R
V
A
S
A
A
D
A
Q
E
V
C
A
A
I
R
K
E
L
A
S
L
A
--
S
P
--
R
I
A
D
T
V
R
V
L
Y
G
G
S
V
N
A
K
N
V
G
D
I
V
A
Q
D
D
V
D
G
G
L
V
G
G
A
S
L
D
G
E
H
F
A
T
L
-------
20
PsiBlast_PDB
74.27
42%
-16
- C7 -
4YMZ
10
?
A:
[3-251]
-
R
K
T
I
I
A
G
N
W
K
M
N
---
L
S
L
K
E
A
V
F
L
A
H
S
I
R
E
-
K
I
P
--
S
-
I
S
K
D
K
V
S
M
V
F
P
S
T
L
H
L
E
N
V
S
K
I
L
E
---
G
S
S
V
I
V
--
G
--
A
Q
N
C
Y
H
S
G
L
A
A
F
T
G
E
T
S
P
D
Q
L
K
E
I
G
V
K
V
V
M
V
G
H
S
E
R
R
Q
F
L
G
E
S
N
F
F
C
N
D
K
I
R
F
L
L
K
N
E
F
T
V
L
Y
C
V
G
E
T
L
S
E
R
E
S
G
K
T
L
E
V
L
S
S
Q
I
R
E
G
L
K
G
I
D
S
V
F
F
S
N
L
I
L
A
Y
E
P
V
W
A
I
G
T
G
K
V
A
T
P
S
Q
A
Q
E
V
H
S
F
I
R
K
E
I
S
G
L
F
VG
A
S
--
S
I
S
E
S
I
S
I
L
Y
G
G
S
V
K
P
D
N
I
Q
D
L
L
K
E
K
D
I
D
G
G
L
V
G
G
A
S
Q
K
I
S
S
F
A
G
L
F
------
120
HHSearch
74.20
43%
-16
- C7 -
4YMZ
10
?
A:
[2-251]
A
R
K
T
I
I
A
G
N
W
K
M
N
---
L
S
L
K
E
A
V
F
L
A
H
S
I
R
E
-
K
I
P
--
S
I
S
K
D
K
V
S
M
V
F
P
S
T
-
L
H
L
E
N
V
S
K
I
L
E
---
G
S
S
V
I
V
--
G
--
A
Q
N
C
Y
H
S
G
L
A
A
F
T
G
E
T
S
P
D
Q
L
K
E
I
G
V
K
V
V
M
V
G
H
S
E
R
R
Q
F
L
G
E
S
N
F
F
C
N
D
K
I
R
F
L
L
K
N
E
F
T
V
L
Y
C
V
G
E
T
L
S
E
R
E
S
G
K
T
L
E
V
L
S
S
Q
I
R
E
G
L
K
G
I
D
S
V
F
F
S
N
L
I
L
A
Y
E
P
V
W
A
I
G
T
G
K
V
A
T
P
S
Q
A
Q
E
V
H
S
F
I
R
K
E
I
S
G
L
F
--
V
G
AS
S
I
S
E
S
I
S
I
L
Y
G
G
S
V
K
P
D
N
I
Q
D
L
L
K
E
K
D
I
D
G
G
L
V
G
G
A
S
Q
K
I
S
S
F
A
G
L
F
------
44
PsiBlast_CBE
73.05
42%
-13
- C7 -
4YMZ
8
?
B:
[3-251]
-
R
K
T
I
I
A
G
N
W
K
M
N
---
L
S
L
K
E
A
V
F
L
A
H
S
I
R
E
-
K
I
P
--
S
-
I
S
K
D
K
V
S
M
V
F
P
S
T
L
H
L
E
N
V
S
K
I
L
E
---
G
S
S
V
I
V
--
G
--
A
Q
N
C
Y
H
S
G
L
A
A
F
T
G
E
T
S
P
D
Q
L
K
E
I
G
V
K
V
V
M
V
G
H
S
E
R
R
Q
F
L
G
E
S
N
F
F
C
N
D
K
I
R
F
L
L
K
N
E
F
T
V
L
Y
C
V
G
E
T
L
S
E
R
E
S
G
K
T
L
E
V
L
S
S
Q
I
R
E
G
L
K
G
I
D
S
V
F
F
S
N
L
I
L
A
Y
E
P
V
W
A
I
G
T
G
K
V
A
T
P
S
Q
A
Q
E
V
H
S
F
I
R
K
E
I
S
G
L
F
VG
A
S
--
S
I
S
E
S
I
S
I
L
Y
G
G
S
V
K
P
D
N
I
Q
D
L
L
K
E
K
D
I
D
G
G
L
V
G
G
A
S
Q
K
I
S
S
F
A
G
L
F
------
80
PsiBlast_CBE
72.22
42%
-5
- C7 -
4FF7
13
TPIS_YEAST
B:
[3-244]
-
R
T
F
F
V
G
G
N
F
K
L
N
---
G
S
K
Q
S
I
K
E
I
V
E
R
L
N
T
A
S
I
P
-----
E
N
V
E
V
V
I
C
P
P
A
-
T
Y
L
D
Y
S
V
S
L
V
K
---
K
P
Q
V
T
V
--
G
--
A
Q
N
A
Y
L
K
A
S
G
A
F
T
G
E
N
S
V
D
Q
I
K
D
V
G
A
K
W
V
I
L
G
H
S
E
R
R
S
Y
F
H
E
D
D
K
F
I
A
D
K
T
K
F
A
L
G
Q
G
V
G
V
I
L
S
I
G
E
T
L
E
E
K
K
A
G
K
T
L
D
V
V
E
R
Q
L
N
A
V
L
E
E
V
K
D
W
--
T
N
V
V
V
A
Y
E
P
V
W
A
I
G
T
G
L
A
A
T
P
E
D
A
Q
D
I
H
A
S
I
R
K
F
L
A
S
K
L
--
G
D
--
K
A
A
S
E
L
R
I
L
Y
G
G
S
A
N
G
S
N
A
V
T
F
K
D
K
A
D
V
D
G
F
L
V
G
G
A
S
L
K
P
E
-
F
V
D
I
I
------
81
PsiBlast_CBE
71.26
42%
-9
- C7 -
4FF7
9
TPIS_YEAST
A:
[3-244]
-
R
T
F
F
V
G
G
N
F
K
L
N
---
G
S
K
Q
S
I
K
E
I
V
E
R
L
N
T
A
S
I
P
-----
E
N
V
E
V
V
I
C
P
P
A
-
T
Y
L
D
Y
S
V
S
L
V
K
---
K
P
Q
V
T
V
--
G
--
A
Q
N
A
Y
L
K
A
S
G
A
F
T
G
E
N
S
V
D
Q
I
K
D
V
G
A
K
W
V
I
L
G
H
S
E
R
R
S
Y
F
H
E
D
D
K
F
I
A
D
K
T
K
F
A
L
G
Q
G
V
G
V
I
L
S
I
G
E
T
L
E
E
K
K
A
G
K
T
L
D
V
V
E
R
Q
L
N
A
V
L
E
E
V
K
D
W
--
T
N
V
V
V
A
Y
E
P
V
W
A
I
G
T
G
L
A
A
T
P
E
D
A
Q
D
I
H
A
S
I
R
K
F
L
A
S
K
L
--
G
D
--
K
A
A
S
E
L
R
I
L
Y
G
G
S
A
N
G
S
N
A
V
T
F
K
D
K
A
D
V
D
G
F
L
V
G
G
A
S
L
K
P
E
-
F
V
D
I
I
------
66
PsiBlast_CBE
70.24
42%
-10
- C7 -
7TIM
1
TPIS_YEAST
B:
[2-243]
-
R
T
F
F
V
G
G
N
F
K
L
N
---
G
S
K
Q
S
I
K
E
I
V
E
R
L
N
T
A
S
I
P
-----
E
N
V
E
V
V
I
C
P
P
A
-
T
Y
L
D
Y
S
V
S
L
V
K
---
K
P
Q
V
T
V
--
G
--
A
Q
N
A
Y
L
K
A
S
G
A
F
T
G
E
N
S
V
D
Q
I
K
D
V
G
A
K
W
V
I
L
G
H
S
E
R
R
S
Y
F
H
E
D
D
K
F
I
A
D
K
T
K
F
A
L
G
Q
G
V
G
V
I
L
C
I
G
E
T
L
E
E
K
K
A
G
K
T
L
D
V
V
E
R
Q
L
N
A
V
L
E
E
V
K
D
W
--
T
N
V
V
V
A
Y
E
P
V
W
A
I
G
T
G
L
A
A
T
P
E
D
A
Q
D
I
H
A
S
I
R
K
F
L
A
S
K
L
--
G
D
--
K
A
A
S
E
L
R
I
L
Y
G
G
S
A
N
G
S
N
A
V
T
F
K
D
K
A
D
V
D
G
F
L
V
G
G
A
S
L
K
P
E
-
F
V
D
I
I
------
41
PsiBlast_CBE
69.88
45%
-0
- C7 -
2I9E
2
?
B:
[3-247]
-
R
K
F
V
V
G
G
N
W
K
M
N
GDK
K
Q
I
N
E
I
I
G
F
L
K
-----
S
G
P
--
L
-
N
Q
D
T
E
V
V
V
G
V
P
A
-
I
Y
L
E
L
V
R
T
C
V
P
---
A
S
-
I
G
V
--
A
--
A
Q
N
C
Y
K
V
P
K
G
A
F
T
G
E
I
S
P
A
M
I
K
D
V
G
A
D
W
V
I
L
G
H
S
E
R
R
Q
I
F
G
E
S
D
E
L
I
A
E
K
V
C
H
A
L
E
S
G
L
K
V
I
A
C
I
G
E
T
L
E
E
R
E
A
G
K
T
E
E
V
V
F
R
Q
T
K
A
I
A
A
K
V
N
D
W
--
S
N
V
V
I
A
Y
E
P
V
W
A
I
G
T
G
K
T
A
T
P
Q
Q
A
Q
D
V
H
K
A
L
R
Q
W
I
C
E
N
I
--
D
A
--
K
V
G
N
S
I
R
I
Q
Y
G
G
S
V
T
A
A
N
C
K
E
L
A
S
Q
P
D
I
D
G
F
L
V
G
G
A
S
L
K
P
E
-
F
V
D
I
I
N
A
R
Q
--
78
PsiBlast_CBE
69.60
42%
-9
- C7 -
3YPI
1
TPIS_YEAST
B:
[2-243]
-
R
T
F
F
V
G
G
N
F
K
L
N
---
G
S
K
Q
S
I
K
E
I
V
E
R
L
N
T
A
S
I
P
-----
E
N
V
E
V
V
I
C
P
P
A
-
T
Y
L
D
Y
S
V
S
L
V
K
---
K
P
Q
V
T
V
--
G
--
A
Q
N
A
Y
L
K
A
S
G
A
F
T
G
E
N
S
V
D
Q
I
K
D
V
G
A
K
W
V
I
L
G
Q
S
E
R
R
S
Y
F
H
E
D
D
K
F
I
A
D
K
T
K
F
A
L
G
Q
G
V
G
V
I
L
C
I
G
E
T
L
E
E
K
K
A
G
K
T
L
D
V
V
E
R
Q
L
N
A
V
L
E
E
V
K
D
W
--
T
N
V
V
V
A
Y
E
P
V
W
A
I
G
T
G
L
A
A
T
P
E
D
A
Q
D
I
H
A
S
I
R
K
F
L
A
S
K
L
--
G
D
--
K
A
A
S
E
L
R
I
L
Y
G
G
S
A
N
G
S
N
A
V
T
F
K
D
K
A
D
V
D
G
F
L
V
G
G
A
S
L
K
P
E
-
F
V
D
I
I
------
67
PsiBlast_CBE
69.33
42%
-8
- C7 -
7TIM
1
TPIS_YEAST
A:
[2-243]
-
R
T
F
F
V
G
G
N
F
K
L
N
---
G
S
K
Q
S
I
K
E
I
V
E
R
L
N
T
A
S
I
P
-----
E
N
V
E
V
V
I
C
P
P
A
-
T
Y
L
D
Y
S
V
S
L
V
K
---
K
P
Q
V
T
V
--
G
--
A
Q
N
A
Y
L
K
A
S
G
A
F
T
G
E
N
S
V
D
Q
I
K
D
V
G
A
K
W
V
I
L
G
H
S
E
R
R
S
Y
F
H
E
D
D
K
F
I
A
D
K
T
K
F
A
L
G
Q
G
V
G
V
I
L
C
I
G
E
T
L
E
E
K
K
A
G
K
T
L
D
V
V
E
R
Q
L
N
A
V
L
E
E
V
K
D
W
--
T
N
V
V
V
A
Y
E
P
V
W
A
I
G
T
G
L
A
A
T
P
E
D
A
Q
D
I
H
A
S
I
R
K
F
L
A
S
K
L
--
G
D
--
K
A
A
S
E
L
R
I
L
Y
G
G
S
A
N
G
S
N
A
V
T
F
K
D
K
A
D
V
D
G
F
L
V
G
G
A
S
L
K
P
E
-
F
V
D
I
I
------
79
PsiBlast_CBE
69.00
42%
-10
- C7 -
3YPI
1
TPIS_YEAST
A:
[2-243]
-
R
T
F
F
V
G
G
N
F
K
L
N
---
G
S
K
Q
S
I
K
E
I
V
E
R
L
N
T
A
S
I
P
-----
E
N
V
E
V
V
I
C
P
P
A
-
T
Y
L
D
Y
S
V
S
L
V
K
---
K
P
Q
V
T
V
--
G
--
A
Q
N
A
Y
L
K
A
S
G
A
F
T
G
E
N
S
V
D
Q
I
K
D
V
G
A
K
W
V
I
L
G
Q
S
E
R
R
S
Y
F
H
E
D
D
K
F
I
A
D
K
T
K
F
A
L
G
Q
G
V
G
V
I
L
C
I
G
E
T
L
E
E
K
K
A
G
K
T
L
D
V
V
E
R
Q
L
N
A
V
L
E
E
V
K
D
W
--
T
N
V
V
V
A
Y
E
P
V
W
A
I
G
T
G
L
A
A
T
P
E
D
A
Q
D
I
H
A
S
I
R
K
F
L
A
S
K
L
--
G
D
--
K
A
A
S
E
L
R
I
L
Y
G
G
S
A
N
G
S
N
A
V
T
F
K
D
K
A
D
V
D
G
F
L
V
G
G
A
S
L
K
P
E
-
F
V
D
I
I
------
39
PsiBlast_CBE
68.29
45%
1
- C7 -
2I9E
3
?
D:
[3-247]
-
R
K
F
V
V
G
G
N
W
K
M
N
GDK
K
Q
I
N
E
I
I
G
F
L
K
-----
S
G
P
--
L
-
N
Q
D
T
E
V
V
V
G
V
P
A
-
I
Y
L
E
L
V
R
T
C
V
P
---
A
S
-
I
G
V
--
A
--
A
Q
N
C
Y
K
V
P
K
G
A
F
T
G
E
I
S
P
A
M
I
K
D
V
G
A
D
W
V
I
L
G
H
S
E
R
R
Q
I
F
G
E
S
D
E
L
I
A
E
K
V
C
H
A
L
E
S
G
L
K
V
I
A
C
I
G
E
T
L
E
E
R
E
A
G
K
T
E
E
V
V
F
R
Q
T
K
A
I
A
A
K
V
N
D
W
--
S
N
V
V
I
A
Y
E
P
V
W
A
I
G
T
G
K
T
A
T
P
Q
Q
A
Q
D
V
H
K
A
L
R
Q
W
I
C
E
N
I
--
D
A
--
K
V
G
N
S
I
R
I
Q
Y
G
G
S
V
T
A
A
N
C
K
E
L
A
S
Q
P
D
I
D
G
F
L
V
G
G
A
S
L
K
P
E
-
F
V
D
I
I
N
A
R
Q
--
91
PsiBlast_CBE
67.99
42%
6
- C7 -
1R2R
9
TPIS_RABIT
C:
[4-248]
-
R
K
F
F
V
G
G
N
W
K
M
N
GRK
K
N
L
G
E
L
I
T
T
L
N
A
A
K
---
V
P
--
A
-
D
T
E
---
V
V
C
A
P
P
-
T
A
Y
I
D
F
A
R
Q
K
L
---
D
P
K
I
A
V
--
A
--
A
Q
N
C
Y
K
V
T
N
G
A
F
T
G
E
I
S
P
G
M
I
K
D
C
G
A
T
W
V
V
L
G
H
S
E
R
R
H
V
F
G
E
S
D
E
L
I
G
Q
K
V
A
H
A
L
S
E
G
L
G
V
I
A
C
I
G
E
K
L
D
E
R
E
A
G
I
T
E
K
V
V
F
E
Q
T
K
--
V
I
A
D
N
V
K
D
W
S
K
V
V
L
A
Y
E
P
V
W
A
I
G
T
G
K
T
A
T
P
Q
Q
A
Q
E
V
H
E
K
L
R
G
W
L
K
S
N
V
--
S
D
--
A
V
A
Q
S
T
R
I
I
Y
G
G
S
V
T
G
A
T
C
K
E
L
A
S
Q
P
D
V
D
G
F
L
V
G
G
A
S
L
K
P
E
-
F
V
D
I
I
N
A
K
Q
--
89
PsiBlast_CBE
67.53
42%
7
- C7 -
4OWG
1
TPIS_RABIT
A:
[4-248]
-
R
K
F
F
V
G
G
N
W
K
M
N
GRK
K
N
L
G
E
L
I
T
T
L
N
A
A
K
---
V
P
--
A
-
D
T
E
---
V
V
C
A
P
P
-
T
A
Y
I
D
F
A
R
Q
K
L
---
D
P
K
I
A
V
--
A
--
A
Q
N
C
Y
K
V
T
N
G
A
F
T
G
E
I
S
P
G
M
I
K
D
C
G
A
T
W
V
V
L
G
H
S
E
R
R
H
V
F
G
E
S
D
E
L
I
G
Q
K
V
A
H
A
L
S
E
G
L
G
V
I
A
C
I
G
E
K
L
D
E
R
E
A
G
I
T
E
K
V
V
F
E
Q
T
K
--
V
I
A
D
N
V
K
D
W
S
K
V
V
L
A
Y
E
P
V
W
A
I
G
T
G
K
T
A
T
P
Q
Q
A
Q
E
V
H
E
K
L
R
G
W
L
K
S
N
V
--
S
D
--
A
V
A
Q
S
T
R
I
I
Y
G
G
S
V
T
G
A
T
C
K
E
L
A
S
Q
P
D
V
D
G
F
L
V
G
G
A
S
L
K
P
E
-
F
V
D
I
I
N
A
K
Q
--
69
PsiBlast_CBE
67.49
42%
-8
- C7 -
2YPI
1
TPIS_YEAST
A:
[2-243]
-
R
T
F
F
V
G
G
N
F
K
L
N
---
G
S
K
Q
S
I
K
E
I
V
E
R
L
N
T
A
S
I
P
-----
E
N
V
E
V
V
I
C
P
P
A
-
T
Y
L
D
Y
S
V
S
L
V
K
---
K
P
Q
V
T
V
--
G
--
A
Q
N
A
Y
L
K
A
S
G
A
F
T
G
E
N
S
V
D
Q
I
K
D
V
G
A
K
W
V
I
L
G
H
S
E
R
R
S
Y
F
H
E
D
D
K
F
I
A
D
K
T
K
F
A
L
G
Q
G
V
G
V
I
L
C
I
G
E
T
L
E
E
K
K
A
G
K
T
L
D
V
V
E
R
Q
L
N
A
V
L
E
E
V
K
D
W
--
T
N
V
V
V
A
Y
E
P
V
W
A
I
G
T
G
L
A
A
T
P
E
D
A
Q
D
I
H
A
S
I
R
K
F
L
A
S
K
L
--
G
D
--
K
A
A
S
E
L
R
I
L
Y
G
G
S
A
N
G
S
N
A
V
T
F
K
D
K
A
D
V
D
G
F
L
V
G
G
A
S
L
K
P
E
-
F
V
D
I
I
------
92
PsiBlast_CBE
66.62
42%
8
- C7 -
1R2R
9
TPIS_RABIT
B:
[4-248]
-
R
K
F
F
V
G
G
N
W
K
M
N
GR
K
K
N
L
G
E
L
I
T
T
L
N
A
A
K
---
V
P
--
A
-
D
T
E
---
V
V
C
A
P
P
-
T
A
Y
I
D
F
A
R
Q
K
L
---
D
P
K
I
A
V
--
A
--
A
Q
N
C
Y
K
V
T
N
G
A
F
T
G
E
I
S
P
G
M
I
K
D
C
G
A
T
W
V
V
L
G
H
S
E
R
R
H
V
F
G
E
S
D
E
L
I
G
Q
K
V
A
H
A
L
S
E
G
L
G
V
I
A
C
I
G
E
K
L
D
E
R
E
A
G
I
T
E
K
V
V
F
E
Q
T
K
--
V
I
A
D
N
V
K
D
W
S
K
V
V
L
A
Y
E
P
V
W
A
I
G
T
G
K
T
A
T
P
Q
Q
A
Q
E
V
H
E
K
L
R
G
W
L
K
S
N
V
--
S
D
--
A
V
A
Q
S
T
R
I
I
Y
G
G
S
V
T
G
A
T
C
K
E
L
A
S
Q
P
D
V
D
G
F
L
V
G
G
A
S
L
K
P
E
-
F
V
D
I
I
N
A
K
Q
--
68
PsiBlast_CBE
66.17
42%
-3
- C7 -
2YPI
1
TPIS_YEAST
B:
[2-243]
-
R
T
F
F
V
G
G
N
F
K
L
N
---
G
S
K
Q
S
I
K
E
I
V
E
R
L
N
T
A
S
I
P
-----
E
N
V
E
V
V
I
C
P
P
A
-
T
Y
L
D
Y
S
V
S
L
V
K
---
K
P
Q
V
T
V
--
G
--
A
Q
N
A
Y
L
K
A
S
G
A
F
T
G
E
N
S
V
D
Q
I
K
D
V
G
A
K
W
V
I
L
G
H
S
E
R
R
S
Y
F
H
E
D
D
K
F
I
A
D
K
T
K
F
A
L
G
Q
G
V
G
V
I
L
C
I
G
E
T
L
E
E
K
K
A
G
K
T
L
D
V
V
E
R
Q
L
N
A
V
L
E
E
V
K
D
W
--
T
N
V
V
V
A
Y
E
P
V
W
A
I
G
T
G
L
A
A
T
P
E
D
A
Q
D
I
H
A
S
I
R
K
F
L
A
S
K
L
--
G
D
--
K
A
A
S
E
L
R
I
L
Y
G
G
S
A
N
G
S
N
A
V
T
F
K
D
K
A
D
V
D
G
F
L
V
G
G
A
S
L
K
P
E
-
F
V
D
I
I
------
96
PsiBlast_CBE
65.75
43%
32
- C7 -
1SW7
1
TPIS_CHICK
B:
[4-244]
-
R
K
F
F
V
G
G
N
W
K
M
N
GDK
K
S
L
G
E
L
I
H
T
L
N
G
A
K
L
-
S
------
A
D
-
T
E
V
V
C
G
A
P
S
-
I
Y
L
D
---
F
A
R
Q
---
K
L
D
A
K
I
--
G
VA
A
Q
N
C
Y
K
V
P
K
G
A
F
T
G
E
I
S
P
A
M
I
K
D
I
G
A
A
W
V
I
L
G
H
S
E
R
R
H
V
F
G
E
S
D
E
L
I
G
Q
K
V
A
H
A
L
A
E
G
L
G
V
I
A
C
I
G
E
K
L
D
E
R
E
A
G
I
T
E
K
V
V
F
E
Q
T
K
A
I
A
D
N
V
K
D
W
--
S
K
V
V
L
A
Y
E
P
V
W
A
I
G
T
G
N
S
S
T
P
Q
Q
A
Q
E
V
H
E
K
L
R
G
W
L
K
S
H
V
--
S
D
--
A
V
A
Q
S
T
R
I
I
Y
G
G
S
V
T
G
G
N
C
K
E
L
A
S
Q
H
D
V
D
G
F
L
V
G
G
A
S
L
K
P
E
-
F
V
D
I
I
------
88
PsiBlast_CBE
65.49
42%
8
- C7 -
4OWG
1
TPIS_RABIT
B:
[4-247]
-
R
K
F
F
V
G
G
N
W
K
M
N
GRK
K
N
L
G
E
L
I
T
T
L
N
A
A
K
---
V
P
--
A
-
D
T
E
---
V
V
C
A
P
P
-
T
A
Y
I
D
F
A
R
Q
K
L
---
D
P
K
I
A
V
--
A
--
A
Q
N
C
Y
K
V
T
N
G
A
F
T
G
E
I
S
P
G
M
I
K
D
C
G
A
T
W
V
V
L
G
H
S
E
R
R
H
V
F
G
E
S
D
E
L
I
G
Q
K
V
A
H
A
L
S
E
G
L
G
V
I
A
C
I
G
E
K
L
D
E
R
E
A
G
I
T
E
K
V
V
F
E
Q
T
K
--
V
I
A
D
N
V
K
D
W
S
K
V
V
L
A
Y
E
P
V
W
A
I
G
T
G
K
T
A
T
P
Q
Q
A
Q
E
V
H
E
K
L
R
G
W
L
K
S
N
V
--
S
D
--
A
V
A
Q
S
T
R
I
I
Y
G
G
S
V
T
G
A
T
C
K
E
L
A
S
Q
P
D
V
D
G
F
L
V
G
G
A
S
L
K
P
E
-
F
V
D
I
I
N
A
K
---
97
PsiBlast_CBE
64.62
43%
36
- C7 -
1SW7
1
TPIS_CHICK
A:
[4-244]
-
R
K
F
F
V
G
G
N
W
K
M
N
GD
K
K
S
L
G
E
L
I
H
T
L
N
G
A
K
L
-
S
------
A
D
-
T
E
V
V
C
G
A
P
S
-
I
Y
L
D
---
F
A
R
Q
---
K
L
D
A
K
I
--
G
V
A
A
Q
N
C
Y
K
V
P
K
G
A
F
T
G
E
I
S
P
A
M
I
K
D
I
G
A
A
W
V
I
L
G
H
S
E
R
R
H
V
F
G
E
S
D
E
L
I
G
Q
K
V
A
H
A
L
A
E
G
L
G
V
I
A
C
I
G
E
K
L
D
E
R
E
A
G
I
T
E
K
V
V
F
E
Q
T
K
A
I
A
D
N
V
K
D
W
--
S
K
V
V
L
A
Y
E
P
V
W
A
I
G
T
G
N
S
S
T
P
Q
Q
A
Q
E
V
H
E
K
L
R
G
W
L
K
S
H
V
--
S
D
--
A
V
A
Q
S
T
R
I
I
Y
G
G
S
V
T
G
G
N
C
K
E
L
A
S
Q
H
D
V
D
G
F
L
V
G
G
A
S
L
K
P
E
-
F
V
D
I
I
------