@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : bsu35120: (2016-07-29 )
MKQEKERILKLVEEGKLTAQEALTLIEKLDSDYKEKEEKITALSVHVHDEEEPFTTAKKESGKPSLGAKLFDWIDSAVKKVKEVDLDLNFGHAYDVQHIFQFKDTDFSSVELQIANGSVNIVPWEDDDIRAECQAKVYRADSQDAARHAFLQHIECEIKGNKFFIRTEKKTMKTNVTLYIPQKEYDKIRVKLFNGPVRGEHLHVKEFSAKTTNGVLSFSYLTAEKAIAETANGQIKLASHSCGTIEAETINGLIDLRGKSESIDVQSFNGNIAINVTESDCRSIYAKTTTGNVELAIPDDLAVKAELKSNLGTLSHELMDVEMLKEKNDTIQKEMMFTSNQAHDQNITVFSESLTGAIKLKYSQR
Atome Classification :
(20 SA)
------------------------------------------------------------------------------------------------.........10...---.....20...-----.-....30---..-------------...-----....40..-...--------...50........60....----..----------------..70........80....-....90------------....---...---.100------.....----.-...--110...--...--.120-----------...-.-..---.130.-......140---....------.-...150...-.-..--.160.......170------.----------.--...----------.-...180...-.....190--......--..200.-.....-...-210---....---..-..-220-........-230...--.....240...------...-.-250.---..---...-.---.260....--.-..----------270--.......---..280.....-.-.-290...-------..---..300.-----....---....310.--......320-----......-...330......------------..340-........350.......360...------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------------------------------------------------------------------------------------------M
K
Q
E
K
E
R
I
L
K
L
V
E
E---GKL
T
A
Q
E
A
L
T
-----
L
-
I
E
K
LD----
S
D
-------------
Y
K
E
-----
K
E
EK
I
T
A
L
-
S
V
H
--------
V
HDEEEPFTTAKKESGKPS----L
G
----------------
A
K
L
F
D
W
I
D
S
A
V
K
K
V
K
EVD-
L
D
LNFG------------
H
A
Y
D
---
V
Q
H
---
I
F
--------QFKDT----D-F
S
S
--
V
E
L
Q
IA--NG
S
--
V
N
I
V
-----------PWE-D-D
D
---
I
R
A
E
C
-
Q
A
K
V
Y
RAD----S
Q
D
A
------
A
-
R
H
A
F
L
Q
H
I
E
-
C
-
E
I
--KG
N
K
F
F
I
R
TEKK--------T----------M--KT
N
----------
V
-
T
L
Y
I-PQKE-Y
D
K
I
R
V
K
---
L
FNGPV--RG
E
--
H
-
L
H
V
K
E-FSA-K-T---TN
G
V
---
L
S
-
F
S
-
Y
-
L
-
T
A
E
K
A
I
A
E-T-ANG
Q
--
I
K
L
ASHSCGTI------
E
A
E
-T-I
N
-
G
---
L
I
---DLR-G---KSE
S
I
D
V
Q--S-FN----------G----
N
I
A
I
N
V
T
---
E
S
D
C
R
S
I
YAK-T-T-TG
N
V
E
L
-------AI---PDD--L-----
A
V
K
A
---
E
L
K
S
N
L
G
T
--
L
S
H
E
L
M
D
-------
V
E
M
L
K
E-KN
D
T
I
-
Q
K
E
M
MF------------TSNQ--AHDQ
N
I
T
V
F
SESL
T
G
A
I
K
L
K
YSQR------
45
Fugue
57.32
21%
75
- C3 -
4B3X
3
IF2_THET8
A:
[1-363]
--------------------------------------------------------------------------------------------------
M
A
K
V
R
I
Y
Q
L
A
K
E
---
L
G
M
E
T
Q
E
L
L
E
-----
L
-
L
D
Q
M
G
----
V
A
-------------
Y
K
S
HA
S
T
L
E
E
K
D
A
E
A
V
-
R
E
L
--------
V
K
E
Q
R
G
L
Q
E
K
L
A
E
E
E
R
R
K
S
----
L
P
R
R
P
P
V
V
V
I
M
G
HVDHG
K
T
T
L
L
D
Y
L
R
K
S
R
I
A
E
K
E
G
G
-
G
I
T
Q
H
V
------------
G
A
F
E
---
V
K
T
PQ
G
T
V
--------
V
F
I
D
T
PGHE
A
-
F
T
T
--
I
R
Q
R
G
A
--
K
V
A
D
I
A
V
I
V
-----------
I
A
A
-
D
-
D
G
---
I
M
P
Q
T
-
E
E
A
I
A
H
A
K
----
A
A
G
A
--------------------------
K
L
I
F
A
I
N
K
I
D
--------
L
----------
P
--
Q
A
D
-----------------
P
E
K
V
-
K
R
Q
L
M
E
R
---
G
F
V
P
E
E
--
Y
G
G
--
D
-
A
I
V
I
P
-
I
S
A
-
K
-
T
---
G
Q
G
V
---
Q
D
-
L
----
L
-
E
M
I
L
L
L
A
E
-
L
-
E
D
Y
R
--
A
D
P
N
A
E
P
R
G
V
I
------
L
E
S
-
K
-
L
D
----------
K
Q
A
-
G
---
I
I
A
N
M
L
V
Q
E
G
T
-
F
R
----------
V
----
G
D
Y
V
V
A
G
---
E
A
Y
G
R
I
R
A
M
M
-
D
-
A
-
D
G
N
Q
R
K
-------
E
A
---
G
P
G
--
S
-----
A
V
Q
V
L
GF
Q
E
L
P
H
A
G
D
--
V
V
E
W
V
P
D
-------
L
E
A
A
K
E
-
I
A
E
E
R
-
K
E
E
R
K
A
------------
R
E
E
E
--
E
K
A
R
R
P
R
T
M
A
E
L
L
R
----------------
50
Fugue
48.74
17%
32
- C1 -
4D7E
1
?
A:
[1-413]
-----------------------------------------------------------------------ME
T
L
L
V
VGAG
P
K
A
L
A
V
A
A
K
S
H
V
L
R
Q
L
G
L
S
A
P
R
V
I
A
V
E
A
H
AVG
G
N
W
L
A
S
G
G
W
T
DGRHR
L
-
G
T
S
P
E
----
K
D
IGFPYHSTWARGH
N
R
E
-----
I
N
E
A
M
M
A
F
-
S
W
T
--------
S
F
L
V
E
H
G
T
Y
A
E
W
I
D
R
G
R
P
S
PQ
H
H
V
W
----------------
A
K
Y
L
Q
W
V
A
R
K
I
------
D
-
L
E
L
V
L
G
------------
K
V
R
T
---
I
R
Q
---
G
W
--------
S
V
E
V
A
----
G
---
A
--
T
T
E
L
E
A
--
D
G
L
--
M
I
T
G
-----------
P
G
Q
-
S
-
T
K
---
A
L
A
A
H
-
P
R
V
L
S
I
A
E
----
F
W
D
L
------
A
G
K
R
K
L
P
I
S
S
R
-
A
-
A
V
--
I
G
G
G
E
T
A
G
S
A
L
D
--------
E
----------
L
--
V
R
H
EM--------
L
-
T
I
S
V
-
I
S
P
M
-
A
S
Y
F
E
N
S
---
L
F
S
D
P
T
--
K
W
N
--
A
-
L
S
I
Q
E
-
R
R
D
-
V
-
I
R
R
T
D
R
G
V
---
F
S
-----------
V
R
V
Q
E
-
S
-
L
L
G
D
---
N
R
V
H
H
L
Q
G
R
V
------
T
R
I
-
V
-
G
Q
-
G
D
G
V
A
V
---
T
L
R
-
N
---
E
M
R
A
D
Q
V
H
--
N
-
F
D
----------------
L
V
V
D
A
T
GGQ
P
L
W
F
L
D
L
F
D
S
-
E
-
S
-
A
D
L
L
E
L
-------
A
V
GGP
L
T
Q
--
Q
-----
R
I
E
S
---
S
I
G
Y
D
L
A
V
TG
L
G
A
K
L
Y
L
-------
P
N
M
A
A
L
-
A
Q
G
P
G
-
F
P
--------------------------
N
L
S
C
L
G
E
L
S
D
R
V
L
R
------------
56
HHSearch
44.55
18%
-41
- C4 -
4YGU
6
?
A:
[7-180]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
---
V
R
--------
K
--
V
D
----
A
-
F
S
S
--
I
E
I
T
S
---
V
G
T
--
I
H
F
T
-----------
Q
S
D
-
T
-
Y
S
---
F
R
I
E
G
-
R
E
K
------------------------
Y
V
K
N
T
E
-
T
-
T
V
--
K
D
G
R
L
L
I
G
F
K
D
-----------------------
G
V
T
----------
I
-
W
I
S
A
-
P
--
D
-
L
K
E
V
E
F
T
---
G
-
V
G
E
F
--
N
C
E
K
-
P
-
L
K
L
D
E
-
V
S
F
-
E
-
V
K--
G
V
G
E
---
V
N
-
V
A
-
D
-
L
-
T
C
N
V
L
K
V
A
-
L
R
G
V
G
S
--
A
D
I
H
V
V
-
C
D
Y
L
------
S
A
Q
-
M
G
G
V
-
G
---
S
V
---
T
L
S
-
G
---
S
A
G
R
A
D
I
S
--
K
G
G
I
----------
G
----
G
V
N
T
D
N
L
-------------------------------------------------------------------------------------------------------------------------------------------------
55
HHSearch
43.65
17%
-8
* C4 *
3PET
11
?
A:
[9-202]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
K
L
---
I
T
R
---
D
Y
--------
K
--
V
K
----
E
-
F
N
K
--
I
D
A
G
T
---
V
G
N
--
I
Y
Y
T
-----------
Q
S
T
-
D
-
G
K
---
T
D
L
Q
I
-
Y
G
P
D
----------------------
N
I
V
A
L
I
Q
-
V
-
A
V
--
K
D
N
T
L
F
L
S
I
D
K
S
KKVRN---
F
----------
K
--
K
M
K
----------
I
-
T
I
T
S
-
P
T
---
L
N
G
I
S
F
----
K
G
V
G
D
V
--
H
I
E
N-
G
-
L
T
T
D
N
-
L
D
I
-
E
S
K
---
G
V
G
N
---
V
D
-
I
Q
-
S
-
L
-
T
C
Q
K
L
N
V
Q
-
S
M
G
V
G
D
--
V
K
L
E
G
--------------------------------------
T
A
Q
I
A
A
L
H
--
S
K
G
V
----------
G
----
N
I
E
A
G
N
L
---
R
--
A
N
A
V
E
A
S
S
Q
-
G
-
V
G
D
I
T
C
-------
N
A
---
T
E
S
--
I
-------
D
A
---
A
V
-
R
G
V
G
S
--
I
K
Y
K
-----------------------------------------------------------------------------
42
Fugue
42.91
17%
52
- C- -
5CWW
-
NUP82_CHATD
B:
[3-593]
KIKSFAPAWLNEPAPGHKLFAPK
P
G
P
R
RT
I
A
R
R
GT
E
I
F
V
A
C
GK
Q
I
R
W
G
D
L
A
Q
L
K
E
S
W
E
S
RPSDDGAATAG
Y
R
I
I
K
T
PVADDIR
Q
L
V
M
S
PNQD
F
L
A
V
L
T
S
H
T
V
H
I
C
I
L
P
D
S
---
S
H
L
H
I
Q
D
T
T
P
-----
F
-
K
P
K
F
W
T
L
GP
T
T
-------------
H
V
T
-----
S
R
S
A
V
V
S
A
-
V
W
H
PLGVNGH
A
L
V
T
V
T
E
D
A
I
V
R
V
W
E
L
S
T
A
D
----
R
W
----------------
T
F
D
A
P
T
L
A
I
D
L
K
K
L
A
D
A
T
Y
L
D
Q
D
F
G
VSTSAT
N
K
G
F
S
P
D
A
F
D
MEV
A
A
A
---
C
F
--------
P
T
R
D
S
----
G
G
W
A
P
--
M
T
L
W
L
A
M
T
S
G
D
--
V
Y
A
L
C
PLLPQ
R
W
T
P
P
P
T
L
-
I
-
P
S
---
L
S
A
S
I
-
V
A
K
V
A
A
A
E
D
NPE
S
T
P
E
------
E
-
R
L
V
A
Q
Q
Q
L
E
-
W
M
S
E
--
I
D
N
Q
E
P
K
L
V
E
E
A
--------
T
----------
G
--
E
A
T
----------
I
-
E
V
Y
T
R
P
S
R
P
-
G
L
V
P
K
L
Q
GP
F
D
F
D
L
N
P
--
E
D
E
--
Q
-
D
D
E
V
E
-
L
K
D
-
I
-
Y
---
V
I
G
E
---
K
P
-
R
N
-
G
-
L
-
S
L
N
I
I
C
L
L
-
S
-
T
S
G
Q
--
V
K
I
C
L
D
I
D
G
V
E
A
Q
W
L
P
P
R
S
K
-
N
-
K
R
-
L
---
F
A
---
P
P
P
-
E
---
P
P
S
L
L
T
F
Q
--
T
-
F
D
TLKPAEVTPD
G
----
W
P
M
F
S
E
D
---
A
T
S
P
Y
S
F
Y
V
T
-
H
-
P
-
A
G
I
T
Y
I
-------
S
L
----
T
P
--
W
-----
V
F
R
L
---
E
S
E
L
Q
S
D
S
--
E
A
G
T
E
F
R
-------
I
D
L
L
A
K
-
G
Q
G
S
--
E
R
D
R
I
F
T
Q
T
RTQ
S
P
L
A
A
A
T
S
I
D
--
D
P
D
L
G
Y
F
I
L
S
A
T
Q
T
D
P
I
A
L
F
F
E
T
P
------
53
HHSearch
40.21
15%
44
- C4 -
4OPW
5
?
A:
[7-224]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
------------
N
G
K
L
---
S
T
K
---
K
I
--------
T
I
--
D
----
D
-
F
N
A
--
I
K
F
D
G
---
V
I
D
--
F
N
Y
E
-----------
Q
S
E
S
T
-
P
H
---
I
E
I
T
V
-
D
E
------------------------
N
L
H
P
Y
V
N
-
I
-
D
I
--
Q
D
R
V
L
T
V
G
F
K
G
A
--------
K
VD--------
H
--
F
T
K
----------
F
-
I
V
K
T
-
N
S
K
W
-
L
K
E
V
K
A
S
----
G
N
A
N
F
--
I
A
N
--
S
P
L
K
G
D
E
-
L
K
I
-
N
-
A
N
--
S
N
C
L
---
V
Q
-
L
K
Q
K
-
V
-
E
V
G
K
L
D
L
N
V
S
-
G
S
A
N
--
M
V
V
N
E
L
K
T
D
K
L
------
E
C
S
I
N
-
G
S
-
G
---
T
I
---
N
L
K
A
G
---
N
A
E
E
A
D
Y
S
I
-
T
-
T
D
----------
G
----
E
I
M
A
F
G
V
---
A
--
V
P
E
V
N
C
K
I
T
-
G
-
K
G
S
A
Q
I
-------
H
P
---
T
D
N
--
L
-------
K
A
---
T
I
-
V
G
K
G
N
--
I
R
Y
K
G
P
---------------------------------------------------------------------------
54
HHSearch
39.96
15%
27
- C4 -
4QRK
2
?
A:
[12-219]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
---
I
K
--------
I
V
E
P
N
----
G
-
A
E
K
T
K
L
N
L
N
F
G
--
V
G
K
--
L
N
I
S
-----------
G
N
E
-
E
-
K
L
---
M
K
G
K
F
-
I
Y
S
E
N
-------
E
--------------
W
K
P
E
I
K
-
Y
-
E
V
K
D
K
D
G
E
L
E
I
S
Q
P
G
L
KSGNVSLN
N
----------
K
--
R
N
E
----------
W
-
N
I
N
L
-
N
E
K
I
-
P
T
E
I
K
L
S
---
L
G
T
G
E
F
K
A
D
L
S
--
K
-
I
N
L
K
E
-
L
N
V
-
G
-
M
---
G
V
G
K
---
V
D
-
L
D
-
I
-
S
-
G
---------------------------------------------------------------------------------------------
N
Y
---
K
-
N
N
V
K
V
N
I
E
-
G
-
G
-
V
G
E
A
T
V
-------
Y
L
---
P
K
S
--
I
-----
G
V
K
I
---
K
A
E
K
G
V
G
A
--
V
N
A
N
G
F
I
---------
V
E
G
E
-------
N
I
Y
K
N
S
------------
Q
Y
-
G
--
K
S
K
N
S
I
E
V
N
I
E
A
G
V
G
A
I
N
I
K
Q
---------
66
HHSearch
39.78
22%
-371
- C3 -
1NH2
-
T2AG_YEAST
D:
[22-61]
-------------------------------------------------------------------------------------------------------
L
D
T
L
I
S
D
---
G
R
I
E
A
S
L
A
M
R
-----
V
-
L
E
T
F
D
----
K
V
-------------
V
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
HHSearch
38.89
24%
-271
- C3 -
1VP7
-
EX7S_BORPA
A:
[25-49]
--------------------------------------------------------------------------------------------------
A
E
L
E
S
L
V
S
A
M
E
N
---
G
T
L
P
L
E
Q
S
L
S
-----
A
-
Y
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
HHSearch
37.90
10%
38
- C4 -
3JX8
8
?
A:
[9-233]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
------------
N
G
N
P
---
E
T
R
---
E
I
--------
K
I
--
S
----
D
-
Y
D
E
--
I
T
F
V
G
---
S
A
D
--
F
E
Y
E
-----------
Q
S
D
K
A
-
P
Y
---
L
S
V
T
I
-
D
E
N
------------------------
L
F
D
Y
L
V
-
T
-
E
V
--
E
G
G
T
L
K
I
Y
P
K
S
I
KK------
G
FNNNSYDLRP
T
--
V
Y
K
----------
I
-
K
S
N
S
-
K
E
---
L
K
E
L
N
T
V
----
G
S
G
S
F
--
I
I
S
--
K
P
T
K
V
N
R
-
M
E
I
-
N
M
A
---
G
S
G
N
---
V
E
-
L
R
-
G
P
V
-
K
G
Y
K
L
E
C
N
M
A
-
G
S
G
N
--
I
I
A
K
D
I
Q
L
D
N
L
------
S
C
S
-
L
A
S
S
-
G
---
E
I
---
E
V
I
-
G
---
T
V
D
R
A
S
F
N
V
-
A
-
G
S
----------
G
----
E
I
K
A
F
D
C
---
Q
--
A
R
K
A
E
C
N
-
I
A
S
-
S
G
E
I
S
V
-------
Y
A
---
T
Q
I
--
L
-------
D
A
---
N
I
-
V
G
S
G
E
--
I
H
Y
K
G
D
---------------------------------------------------------------------------
47
Fugue
37.48
12%
45
- C4 -
3PET
11
?
A:
[4-221]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
I
------------
Q
P
S
K
---
K
L
I
---
T
R
--------
D
Y
K
V
K
----
E
-
F
N
K
--
I
D
A
G
-
T
--
V
G
N
--
I
Y
Y
T
-----------
Q
S
T
-
D
-
G
K
---
T
D
L
Q
I
-
Y
G
P
----------------------
D
N
I
V
A
L
I
Q
-
V
-
A
V
--
K
D
N
T
L
F
L
S
I
D
K
S
--------
K
----------
K
VR
N
F
K
----------
K
M
K
I
T
I
-
T
S
P
T
-
L
N
G
I
S
F
K
---
G
V
G
D
V
H
--
I
E
N
--
G
-
L
T
T
D
N
-
L
D
I
-
E
-
S
---
K
G
---------------------------
V
G
N
--
V
D
I
Q
S
L
T
C
Q
K
L
------
N
V
Q
-
S
M
G
V
-
G
---
D
V
---
K
L
E
-
G
---
T
A
Q
I
A
A
L
H
--
S
-
K
G
----------
V
----
G
-
N
I
E
A
G
---
N
L
R
A
N
A
V
E
A
S
S
Q
-
G
-
V
G
D
I
T
C
-------
N
A
---
T
E
S
--
I
-----
D
A
A
V
---
R
G
V
G
S
I
-
K
--
Y
K
G
S
P
T
I
-------
K
S
L
S
K
K
-
G
V
G
T
I
-
K
N
I
---------------------------------------------------
64
HHSearch
35.47
26%
-245
- C3 -
2N5D
-
?
A:
[17-39]
-----------------------------------------------------------------------------------------------------
D
A
L
L
S
A
V
R
D
---
N
R
L
S
I
E
Q
A
V
T
-----
L
-
L
T
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Fugue
35.46
19%
17
- C3 -
4PE6
1
?
A:
[18-339]
------------------------------------------------------------------------------------------------------
K
P
F
I
A
L
S
N
---
G
-
F
I
G
N
G
W
R
Q
-----
T
M
I
A
K
F
E
----
E
A
-------------
A
K
Q
-----
A
Q
A
D
G
L
I
G
-
K
Y
K
--------
V
V
N
--------------------------------------
A
P
G
N
N
S
A
T
E
Q
V
A
Q
I
K
S
L
L
-
L
-----------------
Q
K
P
D
---
A
L
L
---
I
N
--------
P
A
S
P
T
----
A
-
L
Q
P
--
V
I
Q
Q
A
C
--
D
A
G
--
V
K
V
V
-----------
V
F
--
D
-
S
A
---
I
D
A
P
C
--
A
Y
I
L
Q
N
S
----
F
V
D
W
------
A
-
T
Y
A
A
K
P
V
L
E
S
I
-
G
G
--
K
G
N
V
I
V
V
R
G
--------------------------------------
V
-
V
G
S
Q
-
P
E
A
E
M
Y
E
T
T
K
K
I
---
L
A
E
Y
P
-----------------
Q
V
-
K
-
T
---
V
A
T
V
---
T
G
M
C
D
-
G
-
A
-
T
A
Q
K
A
V
L
G
-
V
-
L
P
S
V
---------------------
S
-
T
-
V
D
-
A
---
V
I
G
C
G
D
G
Y
-
G
---
V
A
Q
A
F
A
T
A
--
G
-
K
P
----------
I
----
P
A
V
T
F
E
T
---
N
G
R
A
L
S
Y
W
K
D
-
N
-
K
-
I
D
N
G
S
V
-------
A
V
M
--
S
D
P
--
A
-----
Q
S
V
A
---
A
L
W
A
A
L
D
L
--
L
E
G
R
D
L
P
K
Q
M
T
F
P
I
V
L
I
E
E
K
-
D
R
D
T
W
-
A
S
V
L
K
P
------------
D
E
Y
A
--
A
W
P
W
T
R
E
L
F
R
Q
Q
V
E
A
I
K
T
G
G
E
P
V
Q
PPIPST
41
Fugue
35.45
13%
52
- C4 -
3JX8
8
?
A:
[4-250]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
R
I
D
G
--
N
G
N
--
P
E
T
R
-----------
E
I
K
-
I
-
S
D
YD
E
I
T
F
V
G
-
S
A
D
F
E
Y
E
Q
----
S
D
K
A
P
Y
L
S
V
T
I
-
D
E
N
L
F
D
Y
L
V
-
T
-
E
V
--
E
G
G
T
L
K
I
Y
P
K
S
I
--------
K
KGFNNNSYDL
R
--
P
T
V
----------
Y
-
K
I
K
S
-
N
S
K
E
-
L
K
E
L
N
T
V
---
G
S
G
S
F
I
--
I
S
K
--
P
-
T
K
V
N
R
M
E
I
N
M
A
-
G
---
S
G
N
V
---
E
L
-
R
G
-
P
-
V
-
K
G
Y
K
L
E
C
N
M
A
-
G
S
G
N
--
I
I
A
K
D
I
Q
L
D
N
L
------
S
C
S
-
L
-
A
S
S
G
---
E
I
---
E
V
I
-
G
---
T
V
D
R
A
S
F
N
----
V
A
----------
G
----
S
G
E
I
K
A
F
---
D
C
Q
A
R
K
A
E
C
N
-
I
-
A
S
S
G
E
I
S
V
-------
Y
A
---
T
Q
I
--
L
-----
D
A
N
I
---
V
---
G
S
G
E
--
I
H
Y
K
G
D
P
-------
E
I
S
K
S
I
M
G
S
G
S
I
-
N
K
V
K
--------------------------------------------------
13
PsiBlast_PDB
35.27
28%
0
- C- -
4C2M
-
RPA12_YEAST
I:
[21-122]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
----------
A
----
V
L
G
S
N
V
E
---
C
S
Q
C
K
A
I
Y
P
K
-
S
-
Q
-
F
S
N
L
K
V
V
T
T
T
A
DD
A
F
---
P
S
S
--
L
R
A
K
K
S
V
V
K
T
---
S
L
K
K
N
--------
E
L
K
D
-------
G
A
T
I
K
E
-
K
C
P
Q
C
G
N
E
E
M
N
Y
------------
H
T
L
Q
L
R
S
A
D
E
G
A
T
V
F
Y
T
C
T
S
C
G
Y
K
F
R
----------
65
HHSearch
34.92
23%
-249
* C3 *
1NVP
-
T2AG_HUMAN
D:
[19-44]
--------------------------------------------------------------------------------------------------------
D
E
L
I
Q
S
---
Q
Q
I
T
P
Q
L
A
L
Q
-----
V
-
L
L
Q
F
D
----
K
A
-------------
I
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
HHSearch
34.25
16%
30
- C- -
3LYC
-
?
A:
[29-249]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
N
I
---
T
T
E
---
N
I
--------
P
V
--
S
----
E
-
Y
D
C
--
L
E
L
E
G
G
--
G
M
V
--
V
N
Y
T
-----------
Q
S
D
-
A
P
E
G
---
L
E
I
K
T
-
D
R
------------------------
N
I
F
E
K
Y
E
-
F
-
N
V
--
E
N
H
K
L
K
I
R
P
K
K
E
--------
F
RKHTNFRP--
T
--
E
F
M
----------
V
-
T
A
N
S
-
R
N
---
L
K
K
L
A
A
----
A
G
S
T
H
V
--
N
I
N
S
-
P
-
L
Q
A
E
E
-
F
E
A
-
G
L
A
---
G
S
G
I
---
I
Q
-
F
H
-
D
-
T
A
S
F
T
N
L
K
I
E
I
A
-
G
S
G
D
--
F
V
G
H
K
V
Y
C
E
E
L
------
N
G
D
M
A
-
G
S
-
N
---
T
I
---
V
L
G
-
G
---
T
V
G
I
A
E
F
S
I
-
A
-
G
S
----------
G
----
T
V
R
A
F
D
C
---
T
--
M
D
E
L
E
C
K
I
A
-
G
-
S
G
D
I
E
A
-------
F
V
---
V
N
K
---------
I
K
A
---
E
I
-
A
G
S
G
S
--
V
K
Y
K
G
D
P
--------------------------------------------------------------------------
49
Fugue
34.22
19%
72
- C4 -
4QRK
2
?
A:
[9-220]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
K
E
---
E
I
K
---
I
V
--------
E
P
N
G
A
----
E
-
K
T
K
--
L
N
L
N
F
G
--
V
G
K
--
L
N
I
S
-----------
G
N
E
-
E
---------
K
L
M
K
G
K
F
I
Y
S
E
-----------------
N
E
W
K
P
E
I
K
-
Y
-
E
V
--
K
D
K
D
G
E
L
E
I
S
Q
P
--------
G
----------
L
--
K
S
G
NVSLNN
K
R
N
E
W
-
N
I
N
L
-
N
E
K
I
-
P
T
E
I
K
L
S
---
L
G
T
G
E
F
--
K
A
D
LS
K
-
I
N
L
K
E
-
L
N
V
-
G
M
G
---
V
G
K
V
D
L
D
I
S
-
G
N
-
Y
-
K
-
N
N
V
K
V
N
I
E
-
G
-
G
V
G
E
A
T
V
Y
L
P
K
S
I
G
V
K
I
------
K
A
E
-
K
-
G
V
-
G
---
A
V
---
N
A
N
-
G
F
I
V
E
G
E
N
I
Y
K
N
--
S
-
Q
Y
----------
G
KSK
N
S
I
E
V
N
I
E
---
A
G
V
-
G
A
I
N
I
K
-
Q
-
K
--------------------------------------------------------------------------------------------------------------------------------
62
HHSearch
29.89
17%
-100
- C4 -
4QRK
2
?
A:
[103-164]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
E
I
K
L
S
--
L
-
G
T
----------
G
----
E
F
K
A
D
L
S
---
K
I
N
L
K
E
L
N
V
G
-
M
-
G
-
V
G
K
V
D
L
-------
D
I
---
S
G
N
YK
N
-----
N
V
K
V
---
N
I
E
G
G
V
G
E
--
A
T
V
Y
L
P
K
--------------------------------------------------------------------------
1
PsiBlast_PDB
28.08
31%
-15
- C6 -
4P2L
-
QSOX1_RAT
A:
[120-222]
-------------------------------------------------------------------------------------------------------------------------
M
R
-----
L
-
I
D
A
L
E
----
S
H
-------------
R
D
T
-----
W
P
P
A
C
P
P
L
E
P
A
K
--------
L
K
D
I
N
E
F
F
T
R
S
K
A
E
---------
Y
L
----------------
A
L
I
F
E
R
E
D
S
Y
L
G
R
--
E
V
T
-
L
D
L
S
Q
F
------------
H
A
V
A
---
V
R
R
---
V
L
NSE
S
D
V
V
S
K
F
A
V
T
----
D
-
F
P
S
--
C
Y
L
L
L
R
--
N
G
S
--
V
S
R
V
-----------
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------