@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv3708c: (2016-05-22 )
MGLSIGIVGATGQVGQVMRTLLDERDFPASAVRFFASARSQGRKLAFRGQEIEVEDAETADPSGLDIALFSAGSAMSKVQAPRFAAAGVTVIDNSSAWRKDPDVPLVVSEVNFERDAHRRPKGIIANPNCTTMAAMPVLKVLHDEARLVRLVVSSYQAVSGSGLAGVAELAEQARAVIGGAEQLVYDGGALEFPPPNTYVAPIAFNVVPLAGSLVDDGSGETDEDQKLRFESRKILGIPDLLVSGTCVRVPVFTGHSLSINAEFAQPLSPERARELLDGATGVQLVDVPTPLAAAGVDESLVGRIRRDPGVPDGRGLALFVSGDNLRKGAALNTIQIAELLTADL
Atome Classification :
(36 SA)
.........10........20......--..30......-..40....-....50-----------........--.60........70........80........90........100......-.110...-...--.------120.......130.......140.......150.......160.......170.......--------180.......190..------.....200.......210.......220.......230......-.---240.......250.......260.......270.......280------------......---.------..290--.-..-....300.......310.........320.......330.......340...-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
G
L
S
I
G
I
VGAT
G
Q
V
G
Q
V
M
R
T
L
LDERDF--
P
A
S
A
V
R
F
F
A
S
-
A
R
SQG
R
K
L
-
A
FRG
Q
------------
E
I
E
VEDAE--TADPSG
L
D
I
A
L
FSAGS
A
M
S
KVQAPRFAAA
G
V
T
V
IDNSSAWRKDPDV
P
L
V
V
-
S
EVNFER-DAH--R------RPK
G
I
IANPNC
T
T
M
A
A
M
P
V
L
K
V
L
HD
E
A
R
L
V
R
L
V
V
S
S
Y
QAVSGSG
L
A
G
V
A
E
L
A
E
Q
A
R
A
V
IG--------GAE
Q
L
V
YDGGALEFP------PPN
T
Y
V
A
P
I
A
F
N
V
V
PLA
G
S
LVDDGSGET
D
E
D
Q
K
L
R
FES
R
K
ILGI-P---
D
L
LVSG
T
C
V
R
V
P
V
FTG
H
S
L
S
I
NAEFAQPL
S
P
E
R
A
R
E
L
LDGA--------------TG
V
Q
L
V
---D------VPT
P
L
--
A
-AA-GV
D
E
S
L
V
G
R
I
RRDPG--VPDG
R
G
L
A
L
F
VSGDNLRKGAAL
N
T
I
Q
I
A
E
L
L
TADL-
2
PsiBlast_PDB
99.12
100%
-95
- C3 -
3TZ6
10
DHAS_MYCTU
A:
[1-342]
-
G
L
S
I
G
I
V
G
A
T
G
Q
V
G
Q
V
M
R
T
L
L
D
E
R
D
F
--
P
A
S
A
V
R
F
F
A
S
-
A
R
S
Q
G
R
K
L
-
A
F
R
G
Q
------------
E
I
E
V
E
D
A
E
--
T
A
D
P
S
G
L
D
I
A
L
F
S
A
G
S
A
M
S
K
V
Q
A
P
R
F
A
A
A
G
V
T
V
I
D
N
S
S
A
W
R
K
D
P
D
V
P
L
V
V
-
S
E
V
N
F
E
R
-
D
A
H
--
R
------
R
P
K
G
I
I
A
N
P
N
C
T
T
M
A
A
M
P
V
L
K
V
L
H
D
E
A
R
L
V
R
L
V
V
S
S
Y
Q
A
V
S
G
S
G
L
A
G
V
A
E
L
A
E
Q
A
R
A
V
I
G
--------
G
A
E
Q
L
V
Y
D
G
G
A
L
E
F
P
------
P
P
N
T
Y
V
A
P
I
A
F
N
V
V
P
L
A
G
S
L
V
D
D
G
S
G
E
T
D
E
D
Q
K
L
R
F
E
S
R
K
I
L
G
I
-
P
---
D
L
L
V
S
G
T
C
V
R
V
P
V
F
T
G
H
S
L
S
I
N
A
E
F
A
Q
P
L
S
P
E
R
A
R
E
L
L
D
G
A
--------------
T
G
V
Q
L
V
---
D
------
V
P
T
P
L
--
A
-
A
A
-
G
V
D
E
S
L
V
G
R
I
R
R
D
P
G
--
V
P
D
G
R
G
L
A
L
F
V
S
G
D
N
L
R
K
G
A
A
L
N
T
I
Q
I
A
E
L
L
T
A
---
1
PsiBlast_PDB
98.87
100%
-96
- C3 -
3VOS
9
DHAS_MYCTU
A:
[19-359]
-
G
L
S
I
G
I
V
G
A
T
G
Q
V
G
Q
V
M
R
T
L
L
D
E
R
D
F
--
P
A
S
A
V
R
F
F
A
S
-
A
R
----
K
L
-
A
F
R
G
Q
------------
E
I
E
V
E
D
A
E
--
T
A
D
P
S
G
L
D
I
A
L
F
S
A
G
S
A
M
S
K
V
Q
A
P
R
F
A
A
A
G
V
T
V
I
D
N
S
S
A
W
R
K
D
P
D
V
P
L
V
V
-
S
E
V
N
F
E
R
-
D
A
H
--
R
------
R
P
K
G
I
I
A
N
P
N
C
T
T
M
A
A
M
P
V
L
K
V
L
H
D
E
A
R
L
V
R
L
V
V
S
S
Y
Q
A
V
S
G
S
G
L
A
G
V
A
E
L
A
E
Q
A
R
A
V
I
G
--------
G
A
E
Q
L
V
Y
D
G
G
A
L
E
F
P
------
P
P
N
T
Y
V
A
P
I
A
F
N
V
V
P
L
A
G
S
L
V
D
D
G
S
G
E
T
D
E
D
Q
K
L
R
F
E
S
R
K
I
L
G
I
-
P
---
D
L
L
V
S
G
T
C
V
R
V
P
V
F
T
G
H
S
L
S
I
N
A
E
F
A
Q
P
L
S
P
E
R
A
R
E
L
L
D
G
A
--------------
T
G
V
Q
L
V
---
D
------
V
P
T
P
L
--
A
-
A
A
-
G
V
D
E
S
L
V
G
R
I
R
R
D
P
G
--
V
P
D
G
R
G
L
A
L
F
V
S
G
D
N
L
R
K
G
A
A
L
N
T
I
Q
I
A
E
L
L
T
----
73
HHSearch
98.59
99%
-95
- C3 -
3TZ6
10
DHAS_MYCTU
A:
[1-342]
-
G
L
S
I
G
I
V
G
A
T
G
Q
V
G
Q
V
M
R
T
L
L
D
E
R
D
F
--
P
A
S
A
V
R
F
F
A
S
-
A
R
S
Q
G
R
K
L
-
A
F
R
G
Q
------------
E
I
E
V
E
D
A
E
--
T
A
D
P
S
G
L
D
I
A
L
F
S
A
G
S
A
M
S
K
V
Q
A
P
R
F
A
A
A
G
V
T
V
I
D
N
S
S
A
W
R
K
D
P
D
V
P
L
V
V
-
S
E
V
N
F
E
R
-
D
A
H
--
R
------
R
P
K
G
I
I
A
N
P
N
C
T
T
M
A
A
M
P
V
L
K
V
L
H
D
E
A
R
L
V
R
L
V
V
S
S
Y
Q
A
V
S
G
S
G
L
A
G
V
A
E
L
A
E
Q
A
R
A
V
I
G
--------
G
A
E
Q
L
V
Y
D
G
G
A
L
E
F
P
------
P
P
N
T
Y
V
A
P
I
A
F
N
V
V
P
L
A
G
S
L
V
D
D
G
S
G
E
T
D
E
D
Q
K
L
R
F
E
S
R
K
I
L
G
I
-
P
---
D
L
L
V
S
G
T
C
V
R
V
P
V
F
T
G
H
S
L
S
I
N
A
E
F
A
Q
P
L
S
P
E
R
A
R
E
L
L
D
G
A
--------------
T
G
V
Q
L
V
---
D
------
V
P
T
P
L
--
A
-
A
A
-
G
V
D
E
S
L
V
G
R
I
R
R
D
P
G
VP
D
G
--
R
G
L
A
L
F
V
S
G
D
N
L
R
K
G
A
A
L
N
T
I
Q
I
A
E
L
L
T
A
---
3
PsiBlast_PDB
81.79
41%
-85
- C3 -
2QZ9
-
DHAS2_VIBCH
A:
[6-337]
--
F
N
V
A
I
F
G
A
T
G
A
V
G
E
T
M
L
E
V
L
Q
E
R
E
F
--
P
V
D
E
L
F
L
L
A
S
-
E
R
S
E
G
K
T
Y
-
R
F
N
G
K
------------
T
V
R
V
Q
N
V
E
--
E
F
D
W
S
Q
V
H
I
A
L
F
S
A
G
G
E
L
S
A
K
W
A
P
I
A
A
E
A
G
V
V
V
I
D
N
T
S
H
F
R
Y
D
Y
D
I
P
L
V
V
-
P
E
V
N
P
E
A
-
I
A
E
--
F
------
R
N
R
N
I
I
A
N
P
N
C
S
T
I
Q
M
L
V
A
L
K
P
I
Y
D
A
V
G
I
E
R
I
N
V
T
T
Y
Q
S
V
S
G
A
G
K
A
G
I
D
E
L
A
G
Q
T
A
K
L
L
N
--------
G
------------
Y
P
A
-----
E
T
N
T
F
S
Q
Q
I
A
F
N
C
I
P
Q
I
D
Q
F
M
D
N
G
Y
--
T
K
E
E
M
K
M
V
W
E
T
Q
K
I
F
N
D
-
P
---
S
I
M
V
N
P
T
C
V
R
V
P
V
F
Y
G
H
A
E
A
V
H
V
E
T
R
A
P
I
D
A
E
Q
V
M
D
M
L
E
Q
T
--------------
D
G
I
E
L
F
R
G
A
D
------
F
P
T
Q
V
--
R
D
A
G
-
G
K
D
H
V
L
V
G
R
V
R
N
D
----
I
S
H
H
S
G
I
N
L
W
V
V
A
D
N
V
R
K
G
A
A
T
N
A
V
Q
I
A
E
L
L
V
R
D
Y
-
17
PsiBlast_PDB
77.21
39%
-78
- C3 -
4R3N
7
?
A:
[2-341]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
--
P
I
D
K
I
R
Y
L
A
S
-
A
R
S
A
G
K
S
L
-
K
F
K
D
Q
------------
D
I
T
I
E
E
T
T
--
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
-
P
E
V
N
A
H
A
L
D
A
H
--
N
---------
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
DGVKPCD
L
H
A
E
I
L
P
S
G
G
D
K
K
H
Y
--------------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
-
D
---
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
--------------
P
G
A
V
L
E
---
D
DVAHQ
I
Y
P
Q
A
I
--
N
-
A
V
-
G
S
R
D
T
F
V
G
R
I
R
K
D
----
L
D
A
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
-----
26
PsiBlast_CBE
77.16
39%
-81
- C3 -
4R51
12
?
A:
[2-341]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
--
P
I
D
K
I
R
Y
L
A
S
-
A
R
S
A
G
K
S
L
-
K
F
K
D
Q
------------
D
I
T
I
E
E
T
T
--
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
-
P
E
V
N
A
H
A
L
D
A
H
--
N
---------
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
DGVKPCD
L
H
A
E
I
L
P
S
G
G
D
K
K
H
Y
--------------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
-
D
---
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
--------------
P
G
A
V
L
E
---
D
DVAHQ
I
Y
P
Q
A
I
--
N
-
A
V
-
G
S
R
D
T
F
V
G
R
I
R
K
D
----
L
D
A
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
-----
24
PsiBlast_CBE
76.96
39%
-79
- C3 -
4R54
4
?
A:
[2-341]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
--
P
I
D
K
I
R
Y
L
A
S
-
A
R
S
A
G
K
S
L
-
K
F
K
D
Q
------------
D
I
T
I
E
E
T
T
--
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
-
P
E
V
N
A
H
A
L
D
A
H
--
N
---------
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
DGVKPCD
L
H
A
E
I
L
P
S
G
G
D
K
K
H
Y
--------------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
-
D
---
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
--------------
P
G
A
V
L
E
---
D
DVAHQI
Y
P
Q
A
I
--
N
-
A
V
-
G
S
R
D
T
F
V
G
R
I
R
K
D
----
L
D
A
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
-----
81
HHSearch
76.66
40%
-73
* C3 *
4R3N
8
?
A:
[2-344]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
--
P
I
D
K
I
R
Y
L
A
S
-
A
R
S
A
G
K
S
L
-
K
F
K
D
Q
------------
D
I
T
I
E
E
T
T
--
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
-
P
E
V
N
A
H
A
-
L
D
A
----------
H
N
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
--------
D
G
V
------
K
P
C
D
L
H
A
E
I
LPS
G
G
D
K
K
H
Y
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
--
D
Y
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
-
D
---
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
--------------
P
G
A
V
L
E
---
D
DVAHQ
I
Y
P
Q
A
I
--
N
-
A
V
-
G
S
R
D
T
F
V
G
R
I
R
K
D
L
D
--
A
E
--
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
H
E
R
--
16
PsiBlast_PDB
76.61
39%
-81
- C3 -
3Q1L
1
?
A:
[2-341]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
--
P
I
D
K
I
R
Y
L
A
S
-
A
R
S
A
G
K
S
L
-
K
F
K
D
Q
------------
D
I
T
I
E
E
T
T
--
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
-
P
E
V
N
A
H
A
L
D
A
H
--
N
---------
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
DGVKPCD
L
H
A
E
I
L
P
S
G
G
D
K
K
H
Y
--------------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
-
D
---
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
--------------
P
G
A
V
L
E
---
D
DVAHQI
Y
P
Q
A
I
--
N
-
A
V
-
G
S
R
D
T
F
V
G
R
I
R
K
D
----
L
D
A
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
-----
19
PsiBlast_PDB
76.54
39%
-79
- C3 -
4R41
10
?
A:
[2-341]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
--
P
I
D
K
I
R
Y
L
A
S
-
A
R
S
A
G
K
S
L
-
K
F
K
D
Q
------------
D
I
T
I
E
E
T
T
--
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
-
P
E
V
N
A
H
A
L
D
A
H
--
N
---------
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
DGVKPCD
L
H
A
E
I
L
P
S
G
G
D
K
K
H
Y
--------------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
-
D
---
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
--------------
P
G
A
V
L
E
---
D
DVAHQ
I
Y
P
Q
A
I
--
N
-
A
V
-
G
S
R
D
T
F
V
G
R
I
R
K
D
----
L
D
A
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
-----
10
PsiBlast_PDB
76.51
39%
-79
- C3 -
3PWK
8
?
A:
[2-341]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
--
P
I
D
K
I
R
Y
L
A
S
-
A
R
S
A
G
K
S
L
-
K
F
K
D
Q
------------
D
I
T
I
E
E
T
T
--
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
-
P
E
V
N
A
H
A
L
D
A
H
--
N
---------
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
DGVKPCD
L
H
A
E
I
L
P
S
G
G
D
K
K
H
Y
--------------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
-
D
---
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
--------------
P
G
A
V
L
E
---
D
DVAHQI
Y
P
Q
A
I
--
N
-
A
V
-
G
S
R
D
T
F
V
G
R
I
R
K
D
----
L
D
A
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
-----
39
PsiBlast_CBE
76.43
39%
-78
- C3 -
3PWS
2
?
B:
[2-341]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
--
P
I
D
K
I
R
Y
L
A
S
-
A
R
S
A
G
K
S
L
-
K
F
K
D
Q
------------
D
I
T
I
E
E
T
T
--
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
-
P
E
V
N
A
H
A
L
D
A
H
--
N
---------
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
DGVKPCDL
H
A
E
I
L
P
S
G
G
D
K
K
H
Y
--------------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
-
D
---
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
--------------
P
G
A
V
L
E
---
D
DVAHQI
Y
P
Q
A
I
--
N
-
A
V
-
G
S
R
D
T
F
V
G
R
I
R
K
D
----
L
D
A
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
-----
27
PsiBlast_CBE
76.42
39%
-78
- C3 -
4R4J
7
?
B:
[2-341]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
--
P
I
D
K
I
R
Y
L
A
S
-
A
R
S
A
G
K
S
L
-
K
F
K
D
Q
------------
D
I
T
I
E
E
T
T
--
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
-
P
E
V
N
A
H
A
L
D
A
H
--
N
---------
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
DGVKPCDL
H
A
E
I
L
P
S
G
G
D
K
K
H
Y
--------------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
-
D
---
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
--------------
P
G
A
V
L
E
---
D
DVAHQI
Y
P
Q
A
I
--
N
-
A
V
-
G
S
R
D
T
F
V
G
R
I
R
K
D
----
L
D
A
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
-----
6
PsiBlast_PDB
76.30
39%
-80
- C3 -
2GYY
-
?
A:
[2-341]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
--
P
I
D
K
I
R
Y
L
A
S
-----
G
K
S
L
-
K
F
K
D
Q
------------
D
I
T
I
E
E
T
T
--
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
-
P
E
V
N
A
H
A
L
D
A
H
--
N
---------
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
DGVKPCD
L
H
A
E
I
L
P
S
G
G
D
K
K
H
Y
--------------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
-
D
---
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
--------------
P
G
A
V
L
E
---
D
DVAHQ
I
Y
P
Q
A
I
--
N
-
A
V
-
G
S
R
D
T
F
V
G
R
I
R
K
D
----
L
D
A
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
-----
32
PsiBlast_CBE
76.28
39%
-82
- C3 -
3Q1L
1
?
C:
[2-341]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
--
P
I
D
K
I
R
Y
L
A
S
-
A
R
S
A
G
K
S
L
-
K
F
K
D
Q
------------
D
I
T
I
E
E
T
T
--
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
-
P
E
V
N
A
H
A
L
D
A
H
--
N
---------
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
DGVKPCDL
H
A
E
I
L
P
S
G
G
D
K
K
H
Y
--------------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
-
D
---
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
--------------
P
G
A
V
L
E
---
D
DVAHQI
Y
P
Q
A
I
--
N
-
A
V
-
G
S
R
D
T
F
V
G
R
I
R
K
D
----
L
D
A
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
-----
12
PsiBlast_PDB
76.28
39%
-81
- C3 -
3PYL
1
?
A:
[2-341]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
--
P
I
D
K
I
R
Y
L
A
S
-
A
R
S
A
G
K
S
L
-
K
F
K
D
Q
------------
D
I
T
I
E
E
T
T
--
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
-
P
E
V
N
A
H
A
L
D
A
H
--
N
---------
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
DGVKPCD
L
H
A
E
I
L
P
S
G
G
D
K
K
H
Y
--------------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
-
D
---
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
--------------
P
G
A
V
L
E
---
D
DVAHQ
I
Y
P
Q
A
I
--
N
-
A
V
-
G
S
R
D
T
F
V
G
R
I
R
K
D
----
L
D
A
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
-----
28
PsiBlast_CBE
76.26
39%
-77
- C3 -
4R41
8
?
B:
[2-341]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
--
P
I
D
K
I
R
Y
L
A
S
-
A
R
S
A
G
K
S
L
-
K
F
K
D
Q
------------
D
I
T
I
E
E
T
T
--
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
-
P
E
V
N
A
H
A
L
D
A
H
--
N
---------
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
DGVKPCDL
H
A
E
I
L
P
S
G
G
D
K
K
H
Y
--------------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
-
D
---
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
--------------
P
G
A
V
L
E
---
D
DVAHQI
Y
P
Q
A
I
--
N
-
A
V
-
G
S
R
D
T
F
V
G
R
I
R
K
D
----
L
D
A
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
-----
20
PsiBlast_PDB
76.26
39%
-75
- C3 -
4R4J
6
?
A:
[2-341]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
--
P
I
D
K
I
R
Y
L
A
S
-
A
R
S
A
G
K
S
L
-
K
F
K
D
Q
------------
D
I
T
I
E
E
T
T
--
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
-
P
E
V
N
A
H
A
L
D
A
H
--
N
---------
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
DGVKPCD
L
H
A
E
I
L
P
S
G
G
D
K
K
H
Y
--------------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
-
D
---
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
--------------
P
G
A
V
L
E
---
D
DVAHQI
Y
P
Q
A
I
--
N
-
A
V
-
G
S
R
D
T
F
V
G
R
I
R
K
D
----
L
D
A
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
-----
15
PsiBlast_PDB
76.26
39%
-78
- C3 -
3Q11
5
?
A:
[2-341]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
--
P
I
D
K
I
R
Y
L
A
S
-
A
R
S
A
G
K
S
L
-
K
F
K
D
Q
------------
D
I
T
I
E
E
T
T
--
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
-
P
E
V
N
A
H
A
L
D
A
H
--
N
---------
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
DGVKPCD
L
H
A
E
I
L
P
S
G
G
D
K
K
H
Y
--------------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
-
D
---
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
--------------
P
G
A
V
L
E
---
D
DVAHQ
I
Y
P
Q
A
I
--
N
-
A
V
-
G
S
R
D
T
F
V
G
R
I
R
K
D
----
L
D
A
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
-----
34
PsiBlast_CBE
76.24
39%
-78
- C3 -
3Q11
5
?
B:
[2-341]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
--
P
I
D
K
I
R
Y
L
A
S
-
A
R
S
A
G
K
S
L
-
K
F
K
D
Q
------------
D
I
T
I
E
E
T
T
--
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
-
P
E
V
N
A
H
A
L
D
A
H
--
N
---------
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
DGVKPCDL
H
A
E
I
L
P
S
G
G
D
K
K
H
Y
--------------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
-
D
---
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
--------------
P
G
A
V
L
E
---
D
DVAHQI
Y
P
Q
A
I
--
N
-
A
V
-
G
S
R
D
T
F
V
G
R
I
R
K
D
----
L
D
A
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
-----
35
PsiBlast_CBE
76.23
39%
-79
- C3 -
3PZB
5
?
B:
[2-341]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
--
P
I
D
K
I
R
Y
L
A
S
-
A
R
S
A
G
K
S
L
-
K
F
K
D
Q
------------
D
I
T
I
E
E
T
T
--
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
-
P
E
V
N
A
H
A
L
D
A
H
--
N
---------
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
DGVKPCDL
H
A
E
I
L
P
S
G
G
D
K
K
H
Y
--------------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
-
D
---
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
--------------
P
G
A
V
L
E
---
D
DVAHQI
Y
P
Q
A
I
--
N
-
A
V
-
G
S
R
D
T
F
V
G
R
I
R
K
D
----
L
D
A
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
-----
40
PsiBlast_CBE
76.21
39%
-77
- C3 -
3PWK
8
?
B:
[2-341]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
--
P
I
D
K
I
R
Y
L
A
S
-
A
R
S
A
G
K
S
L
-
K
F
K
D
Q
------------
D
I
T
I
E
E
T
T
--
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
-
P
E
V
N
A
H
A
L
D
A
H
--
N
---------
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
DGVKPCDL
H
A
E
I
L
P
S
G
G
D
K
K
H
Y
--------------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
-
D
---
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
--------------
P
G
A
V
L
E
---
D
DVAHQI
Y
P
Q
A
I
--
N
-
A
V
-
G
S
R
D
T
F
V
G
R
I
R
K
D
----
L
D
A
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
-----
25
PsiBlast_CBE
76.10
39%
-78
- C3 -
4R51
8
?
B:
[2-341]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
--
P
I
D
K
I
R
Y
L
A
S
-
A
R
S
A
G
K
S
L
-
K
F
K
D
Q
------------
D
I
T
I
E
E
T
T
--
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
-
P
E
V
N
A
H
A
L
D
A
H
--
N
---------
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
DGVKPCDL
H
A
E
I
L
P
S
G
G
D
K
K
H
Y
--------------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
-
D
---
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
--------------
P
G
A
V
L
E
---
D
DVAHQI
Y
P
Q
A
I
--
N
-
A
V
-
G
S
R
D
T
F
V
G
R
I
R
K
D
----
L
D
A
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
-----
14
PsiBlast_PDB
76.07
39%
-77
- C3 -
3PZB
6
?
A:
[2-341]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
--
P
I
D
K
I
R
Y
L
A
S
-
A
R
S
A
G
K
S
L
-
K
F
K
D
Q
------------
D
I
T
I
E
E
T
T
--
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
-
P
E
V
N
A
H
A
L
D
A
H
--
N
---------
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
DGVKPCD
L
H
A
E
I
L
P
S
G
G
D
K
K
H
Y
--------------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
-
D
---
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
--------------
P
G
A
V
L
E
---
D
DVAHQ
I
Y
P
Q
A
I
--
N
-
A
V
-
G
S
R
D
T
F
V
G
R
I
R
K
D
----
L
D
A
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
-----
30
PsiBlast_CBE
76.02
39%
-79
- C3 -
4R3N
10
?
B:
[2-341]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
--
P
I
D
K
I
R
Y
L
A
S
-
A
R
S
A
G
K
S
L
-
K
F
K
D
Q
------------
D
I
T
I
E
E
T
T
--
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
-
P
E
V
N
A
H
A
L
D
A
H
--
N
---------
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
DGVKPCDL
H
A
E
I
L
P
S
G
G
D
K
K
H
Y
--------------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
-
D
---
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
--------------
P
G
A
V
L
E
---
D
DVAHQI
Y
P
Q
A
I
--
N
-
A
V
-
G
S
R
D
T
F
V
G
R
I
R
K
D
----
L
D
A
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
-----
13
PsiBlast_PDB
76.00
39%
-77
- C3 -
3PYX
6
?
A:
[2-341]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
--
P
I
D
K
I
R
Y
L
A
S
-
A
R
S
A
G
K
S
L
-
K
F
K
D
Q
------------
D
I
T
I
E
E
T
T
--
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
-
P
E
V
N
A
H
A
L
D
A
H
--
N
---------
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
DGVKPCD
L
H
A
E
I
L
P
S
G
G
D
K
K
H
Y
--------------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
-
D
---
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
--------------
P
G
A
V
L
E
---
D
DVAHQ
I
Y
P
Q
A
I
--
N
-
A
V
-
G
S
R
D
T
F
V
G
R
I
R
K
D
----
L
D
A
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
-----
11
PsiBlast_PDB
75.96
39%
-79
- C3 -
3PWS
3
?
A:
[2-341]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
--
P
I
D
K
I
R
Y
L
A
S
-
A
R
S
A
G
K
S
L
-
K
F
K
D
Q
------------
D
I
T
I
E
E
T
T
--
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
-
P
E
V
N
A
H
A
L
D
A
H
--
N
---------
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
DGVKPCD
L
H
A
E
I
L
P
S
G
G
D
K
K
H
Y
--------------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
-
D
---
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
--------------
P
G
A
V
L
E
---
D
DVAHQ
I
Y
P
Q
A
I
--
N
-
A
V
-
G
S
R
D
T
F
V
G
R
I
R
K
D
----
L
D
A
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
-----
22
PsiBlast_CBE
75.90
39%
-76
- C3 -
4R5H
8
?
A:
[2-341]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
--
P
I
D
K
I
R
Y
L
A
S
-
A
R
S
A
G
K
S
L
-
K
F
K
D
Q
------------
D
I
T
I
E
E
T
T
--
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
-
P
E
V
N
A
H
A
L
D
A
H
--
N
---------
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
DGVKPCD
L
H
A
E
I
L
P
S
G
G
D
K
K
H
Y
--------------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
-
D
---
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
--------------
P
G
A
V
L
E
---
D
DVAHQ
I
Y
P
Q
A
I
--
N
-
A
V
-
G
S
R
D
T
F
V
G
R
I
R
K
D
----
L
D
A
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
-----
36
PsiBlast_CBE
75.72
39%
-76
- C3 -
3PYX
6
?
B:
[2-341]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
--
P
I
D
K
I
R
Y
L
A
S
-
A
R
S
A
G
K
S
L
-
K
F
K
D
Q
------------
D
I
T
I
E
E
T
T
--
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
-
P
E
V
N
A
H
A
L
D
A
H
--
N
---------
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
DGVKPCDL
H
A
E
I
L
P
S
G
G
D
K
K
H
Y
--------------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
-
D
---
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
--------------
P
G
A
V
L
E
---
D
DVAHQI
Y
P
Q
A
I
--
N
-
A
V
-
G
S
R
D
T
F
V
G
R
I
R
K
D
----
L
D
A
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
-----
18
PsiBlast_PDB
75.72
39%
-76
- C3 -
4R3W
8
?
A:
[2-341]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
--
P
I
D
K
I
R
Y
L
A
S
-
A
R
S
A
G
K
S
L
-
K
F
K
D
Q
------------
D
I
T
I
E
E
T
T
--
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
-
P
E
V
N
A
H
A
L
D
A
H
--
N
---------
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
DGVKPCD
L
H
A
E
I
L
P
S
G
G
D
K
K
H
Y
--------------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
-
D
---
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
--------------
P
G
A
V
L
E
---
D
DVAHQ
I
Y
P
Q
A
I
--
N
-
A
V
-
G
S
R
D
T
F
V
G
R
I
R
K
D
----
L
D
A
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
-----
21
PsiBlast_CBE
75.62
39%
-77
- C3 -
4R5H
6
?
B:
[2-341]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
--
P
I
D
K
I
R
Y
L
A
S
-
A
R
S
A
G
K
S
L
-
K
F
K
D
Q
------------
D
I
T
I
E
E
T
T
--
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
-
P
E
V
N
A
H
A
L
D
A
H
--
N
---------
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
DGVKPCDL
H
A
E
I
L
P
S
G
G
D
K
K
H
Y
--------------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
-
D
---
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
--------------
P
G
A
V
L
E
---
D
DVAHQI
Y
P
Q
A
I
--
N
-
A
V
-
G
S
R
D
T
F
V
G
R
I
R
K
D
----
L
D
A
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
-----
23
PsiBlast_CBE
75.60
39%
-78
- C3 -
4R54
4
?
B:
[2-341]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
--
P
I
D
K
I
R
Y
L
A
S
-
A
R
S
A
G
K
S
L
-
K
F
K
D
Q
------------
D
I
T
I
E
E
T
T
--
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
-
P
E
V
N
A
H
A
L
D
A
H
--
N
---------
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
DGVKPCDL
H
A
E
I
L
P
S
G
G
D
K
K
H
Y
--------------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
-
D
---
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
--------------
P
G
A
V
L
E
---
D
DVAHQI
Y
P
Q
A
I
--
N
-
A
V
-
G
S
R
D
T
F
V
G
R
I
R
K
D
----
L
D
A
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
-----
29
PsiBlast_CBE
74.94
39%
-77
- C3 -
4R3W
8
?
B:
[2-341]
-
G
Y
T
V
A
V
V
G
A
T
G
A
V
G
A
Q
M
I
K
M
L
E
E
S
T
L
--
P
I
D
K
I
R
Y
L
A
S
-
A
R
S
A
G
K
S
L
-
K
F
K
D
Q
------------
D
I
T
I
E
E
T
T
--
E
T
A
F
E
G
V
D
I
A
L
F
S
A
G
S
S
T
S
A
K
Y
A
P
Y
A
V
K
A
G
V
V
V
V
D
N
T
S
Y
F
R
Q
N
P
D
V
P
L
V
V
-
P
E
V
N
A
H
A
L
D
A
H
--
N
---------
G
I
I
A
C
P
N
C
S
T
I
Q
M
M
V
A
L
E
P
V
R
Q
K
W
G
L
D
R
I
I
V
S
T
Y
Q
A
V
S
G
A
G
M
G
A
I
L
E
T
Q
R
E
L
R
E
V
L
N
DGVKPCDL
H
A
E
I
L
P
S
G
G
D
K
K
H
Y
--------------
P
I
A
F
N
A
L
P
Q
I
D
V
F
T
D
N
D
Y
--
T
Y
E
E
M
K
M
T
K
E
T
K
K
I
M
E
D
-
D
---
S
I
A
V
S
A
T
C
V
R
I
P
V
L
S
A
H
S
E
S
V
Y
I
E
T
K
E
V
A
P
I
E
E
V
K
A
A
I
A
A
F
--------------
P
G
A
V
L
E
---
D
DVAHQI
Y
P
Q
A
I
--
N
-
A
V
-
G
S
R
D
T
F
V
G
R
I
R
K
D
----
L
D
A
E
K
G
I
H
M
W
V
V
S
D
N
L
L
K
G
A
A
W
N
S
V
Q
I
A
E
T
L
-----
82
HHSearch
68.52
33%
-69
- C3 -
2HJS
10
USG_PSEAE
A:
[5-336]
Q
P
L
N
V
A
V
V
G
A
T
G
S
V
G
E
A
L
V
G
L
L
D
E
--
R
DF
P
L
H
R
L
H
L
L
A
S
-
A
E
S
A
G
Q
R
M
-
G
F
A
E
S
------------
S
L
R
V
G
D
V
D
--
S
F
D
F
S
S
V
G
L
A
F
F
A
A
A
A
E
V
S
R
A
H
A
E
R
A
R
A
A
G
C
S
V
I
D
L
S
G
A
L
E
P
S
-
V
A
P
P
V
M
-
V
S
V
N
A
E
R
-
L
A
S
--
Q
------
A
A
P
F
L
L
S
S
P
C
A
V
A
A
E
L
C
E
V
L
A
P
L
L
A
T
L
D
C
R
Q
L
N
L
T
A
C
L
S
V
S
S
L
G
R
E
G
V
K
E
L
A
R
Q
T
A
E
L
L
N
---------------
A
----
R
P
L
------
E
P
R
L
F
D
R
Q
I
A
F
N
L
L
A
Q
V
G
A
V
D
A
E
G
--
H
S
A
I
E
R
R
I
F
A
E
V
Q
A
L
L
G
E
-
R
---
I
G
P
L
N
V
T
C
I
Q
A
P
V
F
F
G
D
S
L
S
V
T
L
Q
C
A
E
P
V
D
L
A
A
V
T
R
V
L
D
A
T
--------------
K
G
I
E
W
V
---
G
EG
D
---
Y
P
T
V
V
G-
D
-
A
L
-
G
Q
D
E
T
Y
V
G
R
V
R
A
G
Q
A
--
D
P
--
C
Q
V
N
L
W
I
V
S
D
N
V
R
K
G
A
A
L
N
A
V
L
L
G
E
L
L
I
K
H
--
63
Fugue
68.11
33%
-72
- C3 -
2HJS
10
USG_PSEAE
A:
[5-338]
Q
P
L
N
V
A
V
V
G
A
T
G
S
V
G
E
A
L
V
G
L
L
D
E
R
D
F
--
P
L
H
R
L
H
L
L
A
S
-
A
E
S
A
G
-
Q
R
M
G
F
A
E
S
------------
S
L
R
V
G
D
V
D
--
S
F
D
F
S
S
V
G
L
A
F
F
A
A
A
A
E
V
S
R
A
H
A
E
R
A
R
A
A
G
C
S
V
I
D
L
S
G
A
L
E
--
P
S
V
A
P
P
V
M
V
S
V
N
A
E
R
-
L
A
S
--
Q
------
A
A
P
F
L
L
S
S
P
C
A
V
A
A
E
L
C
E
V
L
A
P
L
L
A
T
L
D
C
R
Q
L
N
L
T
A
C
L
S
V
S
S
L
G
R
E
G
V
K
E
L
A
R
Q
T
A
E
L
L
N
--------
A
R
P
-----------
L
------
E
P
R
L
F
D
R
Q
I
A
F
N
L
L
A
Q
V
G
A
V
D
A
E
G
H
--
S
A
I
E
R
R
I
F
A
E
V
Q
A
L
L
G
E
-
R
---
I
G
P
L
N
V
T
C
I
Q
A
P
V
F
F
G
D
S
L
S
V
T
L
Q
C
A
E
P
V
D
L
A
A
V
T
R
V
L
D
A
T
--------------
K
G
I
E
W
V
---
G
EG
D
---
Y
P
T
V
V
--
G
-
D
A
L
G
Q
D
E
T
Y
V
G
R
V
R
A
G
Q
A
--
D
P
--
C
Q
V
N
L
W
I
V
S
D
N
V
R
K
G
A
A
L
N
A
V
L
L
G
E
L
L
I
K
H
Y
L
85
HHSearch
60.39
30%
-61
- C3 -
1YS4
4
DHAS_METJA
A:
[7-352]
M
K
I
K
V
G
V
L
G
A
T
G
S
V
G
Q
R
F
V
Q
L
L
A
D
--
H
--
P
M
F
E
L
T
A
L
A
A
S
E
R
S
A
G
K
K
Y
-
K
D
A
C
Y
WFQDRDIPENIK
D
M
V
V
I
P
T
D
PK
H
E
E
F
E
D
V
D
I
V
F
S
A
L
P
S
D
L
A
K
K
F
E
P
E
F
A
K
E
G
K
L
I
F
S
N
A
S
A
Y
R
M
E
E
D
V
P
L
V
I
-
P
E
V
N
A
D
H
-
L
E
L
I
E
I
Q
R
E
K
RG
W
D
G
A
I
I
T
N
P
N
C
S
T
I
C
A
V
I
T
L
K
P
I
M
D
K
F
G
L
E
A
V
F
I
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T
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A
G
Y
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---------------------------------------------
M
A
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D
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L
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F
I
K
N
E
---
E
E
K
---
M
Q
T
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S
L
K
L
L
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T
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ELA
N
F
K
I
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A
S
C
N
R
V
A
V
I
D
G
H
T
E
S
I
F
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T
K
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A
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P
E
E
I
K
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V
M
D
K
F
DPLKDLNLPTYAKP
I
V
I
R
E
E
---
I
D-----
R
P
Q
P
R
LD
R
-
N
E
G
N
G
M
S
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V
V
G
R
I
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K
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P
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------
F
D
V
K
Y
T
A
L
E
H
N
T
I
R
G
A
A
G
A
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V
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--