@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA3702: (2016-02-20 )
MHNPHESKTDLGAPLDGAVMVLLVDDQAMIGEAVRRSLASEAGIDFHFCSDPQQAVAVANQIKPTVILQDLVMPGVDGLTLLAAYRGNPATRDIPIIVLSTKEEPTVKSAAFAAGANDYLVKLPDAIELVARIRYHSRSYIALQQRDEAYRALRESQQQLLETNLVLQRLMNSDGLTGLSNRRHFDEYLEMEWRRSLREQSQLSLLMIDVDYFKSYNDTFGHVAGDEALRQVAGAIREGCSRSSDLAARYGGEEFAMVLPGTSPGGARLLAEKVRRTVESLQISHDQPRPGSHLTVSIGVSTLVPGGGGQTFRVLIEMADQALYQAKNNGRNQVGLMEQPVPPAPAG
Atome Classification :
(20 SA)
--------------------------------------------------------------------------------------------------------------------------------------.........10........20........30........40......--..50........60........70........80........90........100.......110.......120.......130.......140....--------------------------------.--.-----------------------------.------------------150...------------------------------------------------------....160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------------------------------------------------------------------------------------------------------------------------------MHNPHESKTDLGAPLD
G
A
V
M
V
L
L
VDD
Q
A
M
I
G
E
A
V
R
R
S
L
A
SEAG
I
D
F
H
--FCS
D
P
Q
Q
A
V
A
V
A
N
QI
K
P
T
V
I
L
Q
D
L
VMPGVDG
L
T
L
L
A
AYRGNPAT
R
D
I
P
I
I
V
L
STKEEPTV
K
S
A
AFAAGAN
D
Y
L
V
KLP
D
A
I
E
L
V
A
R
I
R
YHSR
S
Y
I
A
L
Q
Q
R
--------------------------------
D
--
E
-----------------------------
A
------------------
Y
R
A
L
R
E
------------------------------------------------------
S
Q
Q
Q
L
L
E
T
N
L
V
L
Q
R
L
MNSDGLTGLSN
R
R
H
F
D
E
Y
L
E
M
E
W
R
R
S
L
R
E
QSQ
L
S
L
L
M
I
D
V
D
Y
F
KSYNDTFGHVA
G
D
E
A
L
R
Q
V
A
G
A
I
R
E
GCSRSS
D
L
A
A
RYGG
E
E
F
A
M
V
LPGTSP
G
G
A
R
L
L
A
E
K
V
R
R
T
V
E
S
L
QISHDQPRPG
S
H
L
T
V
S
IG
V
S
T
L
VPGGG
G
Q
T
F
R
V
L
I
E
M
A
D
Q
A
L
Y
Q
AKNNGRNQVGLMEQPVPPAPAG
1
PsiBlast_PDB
95.42
100%
-125
- C3 -
3BRE
3
?
A:
[18-339]
-------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
M
V
L
L
V
D
D
Q
A
M
I
G
E
A
V
R
R
S
L
A
S
E
A
G
I
D
F
H
--
F
C
S
D
P
Q
Q
A
V
A
V
A
N
Q
I
K
P
T
V
I
L
Q
D
L
V
M
P
G
V
D
G
L
T
L
L
A
A
Y
R
G
N
P
A
T
R
D
I
P
I
I
V
L
S
T
K
E
E
P
T
V
K
S
A
A
F
A
A
G
A
N
D
Y
L
V
K
L
P
D
A
I
E
L
V
A
R
I
R
Y
H
S
R
S
Y
I
A
L
Q
Q
R
--------------------------------
D
--
E
-----------------------------
A
------------------
Y
R
A
L
R
E
------------------------------------------------------
S
Q
Q
Q
L
L
E
T
N
L
V
L
Q
R
L
M
N
S
D
G
L
T
G
L
S
N
R
R
H
F
D
E
Y
L
E
M
E
W
R
R
S
L
R
E
Q
S
Q
L
S
L
L
M
I
D
V
D
Y
F
K
S
Y
N
D
T
F
G
H
V
A
G
D
E
A
L
R
Q
V
A
G
A
I
R
E
G
C
S
R
S
S
D
L
A
A
R
Y
G
G
E
E
F
A
M
V
L
P
G
T
S
P
G
G
A
R
L
L
A
E
K
V
R
R
T
V
E
S
L
Q
I
S
H
D
Q
P
R
P
G
S
H
L
T
V
S
I
G
V
S
T
L
V
P
G
G
G
G
Q
T
F
R
V
L
I
E
M
A
D
Q
A
L
Y
Q
A
K
N
N
G
R
N
Q
V
G
L
M
E
Q
--------
21
PsiBlast_CBE
94.94
100%
-123
- C3 -
3BRE
3
?
B:
[13-340]
--------------------------------------------------------------------------------------------------------------------------------------------------
A
P
L
D
G
A
V
M
V
L
L
V
D
D
Q
A
M
I
G
E
A
V
R
R
S
L
A
S
E
A
G
I
D
F
H
--
F
C
S
D
P
Q
Q
A
V
A
V
A
N
Q
I
K
P
T
V
I
L
Q
D
L
V
M
P
G
V
D
G
L
T
L
L
A
A
Y
R
G
N
P
A
T
R
D
I
P
I
I
V
L
S
T
K
E
E
P
T
V
K
S
A
A
F
A
A
G
A
N
D
Y
L
V
K
L
P
D
A
I
E
L
V
A
R
I
R
Y
H
S
R
S
Y
I
A
L
Q
Q
R
--------------------------------
D
--
E
-----------------------------
A
------------------
Y
R
A
L
R
E
------------------------------------------------------
S
Q
Q
Q
L
L
E
T
N
L
V
L
Q
R
L
M
N
S
D
G
L
T
G
L
S
N
R
R
H
F
D
E
Y
L
E
M
E
W
R
R
S
L
R
E
Q
S
Q
L
S
L
L
M
I
D
V
D
Y
F
K
S
Y
N
D
T
F
G
H
V
A
G
D
E
A
L
R
Q
V
A
G
A
I
R
E
G
C
S
R
S
S
D
L
A
A
R
Y
G
G
E
E
F
A
M
V
L
P
G
T
S
P
G
G
A
R
L
L
A
E
K
V
R
R
T
V
E
S
L
Q
I
S
H
D
Q
P
R
P
G
S
H
L
T
V
S
I
G
V
S
T
L
V
P
G
G
G
G
Q
T
F
R
V
L
I
E
M
A
D
Q
A
L
Y
Q
A
K
N
N
G
R
N
Q
V
G
L
M
E
Q
P
-------
2
PsiBlast_PDB
85.55
76%
-121
- C3 -
3I5A
3
?
A:
[16-332]
-------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
M
V
L
L
V
D
D
Q
A
M
I
G
E
A
V
R
R
G
L
A
G
H
E
S
I
D
F
H
--
F
C
A
D
P
H
Q
A
I
A
Q
A
V
Q
I
K
P
T
V
I
L
Q
D
L
V
M
P
G
L
D
G
L
T
L
V
R
E
Y
R
S
N
P
L
T
R
D
I
P
I
I
V
L
S
T
K
E
D
P
L
I
K
S
A
A
F
A
A
G
A
N
D
Y
L
V
K
L
P
D
N
I
E
L
V
A
R
I
R
Y
H
S
R
S
Y
M
T
L
L
Q
R
--------------------------------
D
--
E
-----------------------------
A
------------------
Y
R
A
L
R
V
------------------------------------------------------
S
Q
Q
Q
L
L
D
T
N
L
V
L
Q
R
L
M
N
S
D
G
L
T
G
L
S
N
R
R
H
F
D
E
Y
L
E
L
E
W
R
R
A
T
R
D
Q
A
Q
L
S
L
L
M
I
D
V
D
Y
F
K
A
Y
N
D
N
F
G
H
L
E
G
D
E
A
L
R
Q
V
A
K
A
I
R
N
S
C
S
R
P
S
D
L
P
A
R
Y
G
G
E
E
F
A
M
V
L
P
N
T
S
P
G
G
A
R
L
L
A
E
K
L
R
Q
S
V
A
G
M
N
I
P
H
I
A
P
V
P
G
S
S
L
T
V
S
I
G
V
A
T
V
T
P
-
Q
V
G
Q
H
S
R
Q
L
I
L
D
A
D
K
G
L
Y
L
A
K
N
N
G
R
N
Q
V
A
------------
24
PsiBlast_CBE
69.93
34%
-99
* C3 *
2WB4
7
PLED_CAUCN
B:
[156-449]
----------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
I
V
D
D
N
----
E
R
Q
A
Q
R
V
A
A
E
L
G
V
E
H
R
P
V
I
E
S
D
P
E
K
A
K
I
S
A
G
G
P
V
D
L
V
I
V
-
N
A
A
A
K
N
F
D
G
L
R
F
T
A
A
L
R
S
E
E
R
T
R
Q
L
P
V
L
A
M
V
D
P
D
D
R
G
R
M
V
K
A
L
E
I
G
V
N
D
I
L
S
R
P
I
D
P
Q
E
L
S
A
R
V
K
T
Q
I
-------
Q
R
--------------------------------
K
--
R
-----------------------------
Y
------------------
T
D
Y
L
R
N
------------------------------------------------------
N
L
D
H
S
L
E
-------
L
A
V
T
D
Q
L
T
G
L
H
N
R
R
Y
M
T
G
Q
L
D
S
L
V
K
R
A
T
L
G
G
D
P
V
S
A
L
L
I
D
I
D
F
F
K
K
I
N
D
T
F
G
H
D
I
G
D
E
V
L
R
E
F
A
L
R
L
A
S
N
V
-
R
A
I
D
L
P
C
R
Y
G
G
E
E
F
V
V
I
M
P
D
T
A
L
A
D
A
L
R
I
A
E
R
I
R
M
H
V
S
G
S
P
F
T
V
A
H
G
R
E
M
L
N
V
T
I
S
I
G
V
S
A
--
T
A
G
E
G
D
T
P
E
A
L
L
K
R
A
D
E
G
V
Y
Q
A
K
A
S
G
R
N
A
V
-------------
5
PsiBlast_PDB
69.63
34%
-100
- C3 -
2WB4
6
PLED_CAUCN
A:
[156-449]
----------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
I
V
D
D
N
----
E
R
Q
A
Q
R
V
A
A
E
L
G
V
E
H
R
P
V
I
E
S
D
P
E
K
A
K
I
S
A
G
G
P
V
D
L
V
I
V
-
N
A
A
A
K
N
F
D
G
L
R
F
T
A
A
L
R
S
E
E
R
T
R
Q
L
P
V
L
A
M
V
D
P
D
D
R
G
R
M
V
K
A
L
E
I
G
V
N
D
I
L
S
R
P
I
D
P
Q
E
L
S
A
R
V
K
T
Q
I
-------
Q
R
--------------------------------
K
--
R
-----------------------------
Y
------------------
T
D
Y
L
R
N
------------------------------------------------------
N
L
D
H
S
L
E
-------
L
A
V
T
D
Q
L
T
G
L
H
N
R
R
Y
M
T
G
Q
L
D
S
L
V
K
R
A
T
L
G
G
D
P
V
S
A
L
L
I
D
I
D
F
F
K
K
I
N
D
T
F
G
H
D
I
G
D
E
V
L
R
E
F
A
L
R
L
A
S
N
V
-
R
A
I
D
L
P
C
R
Y
G
G
E
E
F
V
V
I
M
P
D
T
A
L
A
D
A
L
R
I
A
E
R
I
R
M
H
V
S
G
S
P
F
T
V
A
H
G
R
E
M
L
N
V
T
I
S
I
G
V
S
A
--
T
A
G
E
G
D
T
P
E
A
L
L
K
R
A
D
E
G
V
Y
Q
A
K
A
S
G
R
N
A
V
-------------
7
PsiBlast_PDB
69.61
34%
-100
- C3 -
2V0N
9
PLED_CAUCN
A:
[155-448]
----------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
I
V
D
D
N
----
E
R
Q
A
Q
R
V
A
A
E
L
G
V
E
H
R
P
V
I
E
S
D
P
E
K
A
K
I
S
A
G
G
P
V
D
L
V
I
V
-
N
A
A
A
K
N
F
D
G
L
R
F
T
A
A
L
R
S
E
E
R
T
R
Q
L
P
V
L
A
M
V
D
P
D
D
R
G
R
M
V
K
A
L
E
I
G
V
N
D
I
L
S
R
P
I
D
P
Q
E
L
S
A
R
V
K
T
Q
I
-------
Q
R
--------------------------------
K
--
R
-----------------------------
Y
------------------
T
D
Y
L
R
N
------------------------------------------------------
N
L
D
H
S
L
E
-------
L
A
V
T
D
Q
L
T
G
L
H
N
R
R
Y
M
T
G
Q
L
D
S
L
V
K
R
A
T
L
G
G
D
P
V
S
A
L
L
I
D
I
D
F
F
K
K
I
N
D
T
F
G
H
D
I
G
D
E
V
L
R
E
F
A
L
R
L
A
S
N
V
-
R
A
I
D
L
P
C
R
Y
G
G
E
E
F
V
V
I
M
P
D
T
A
L
A
D
A
L
R
I
A
E
R
I
R
M
H
V
S
G
S
P
F
T
V
A
H
G
R
E
M
L
N
V
T
I
S
I
G
V
S
A
--
T
A
G
E
G
D
T
P
E
A
L
L
K
R
A
D
E
G
V
Y
Q
A
K
A
S
G
R
N
A
V
-------------
26
PsiBlast_CBE
68.83
34%
-96
- C3 -
1W25
2
PLED_CAUCN
B:
[155-448]
----------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
I
V
D
D
N
----
E
R
Q
A
Q
R
V
A
A
E
L
G
V
E
H
R
PV
I
E
S
D
P
E
K
A
K
I
S
A
G
G
P
V
D
L
V
I
V
-
N
A
A
A
K
N
F
D
G
L
R
F
T
A
A
L
R
S
E
E
R
T
R
Q
L
P
V
L
A
M
V
D
P
D
D
R
G
R
M
V
K
A
L
E
I
G
V
N
D
I
L
S
R
P
I
D
P
Q
E
L
S
A
R
V
K
T
Q
I
-------
Q
R
--------------------------------
K
--
R
-----------------------------
Y
------------------
T
D
Y
L
R
N
------------------------------------------------------
N
L
D
H
S
L
E
-------
L
A
V
T
D
Q
L
T
G
L
H
N
R
R
Y
M
T
G
Q
L
D
S
L
V
K
R
A
T
L
G
G
D
P
V
S
A
L
L
I
D
I
D
F
F
K
K
I
N
D
T
F
G
H
D
I
G
D
E
V
L
R
E
F
A
L
R
L
A
S
N
V
-
R
A
I
D
L
P
C
R
Y
G
G
E
E
F
V
V
I
M
P
D
T
A
L
A
D
A
L
R
I
A
E
R
I
R
M
H
V
S
G
S
P
F
T
V
A
H
G
R
E
M
L
N
V
T
I
S
I
G
V
S
A
--
T
A
G
E
G
D
T
P
E
A
L
L
K
R
A
D
E
G
V
Y
Q
A
K
A
S
G
R
N
A
V
-------------
67
HHSearch
68.57
33%
-109
- C3 -
1W25
4
PLED_CAUCN
A:
[2-454]
--------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
I
L
V
V
D
D
I
E
A
N
V
R
L
L
E
A
K
L
T
A
-
E
Y
Y
E
V
S
--
T
A
M
D
G
P
T
A
L
A
M
A
A
R
D
L
P
D
I
I
L
L
D
V
M
M
P
G
M
D
G
F
T
V
C
R
K
L
K
D
D
P
T
T
R
H
I
P
V
V
L
I
T
A
L
D
G
R
G
D
R
I
Q
G
L
E
S
G
A
S
D
F
L
T
K
P
I
D
D
V
M
L
F
A
R
V
R
S
L
T
R
F
K
L
V
I
D
E
L
R
Q
R
E
A
S
GRRMGVIAGAAARLDG
L
G
G
R
V
L
I
V
D
D
N
E
R
Q
A
Q
R
V
A
A
E
L
GVE
H
R
P
V
I
E
SD
P
E
K
A
K
I
S
A
G
G
P
VD
L
V
I
V
N
AAAKNFD
G
L
R
F
T
A
A
L
R
S
E
ERTRQ
L
P
V
L
A
M
V
D
PDD
R
G
R
M
V
K
A
L
E
I
GVN
D
I
L
S
R
PID
P
Q
E
L
S
A
R
V
K
T
Q
I
Q
R
K
R
Y
T
D
Y
L
R
N
N
L
D
H
S
L
E
L
A
V
T
D
Q
L
T
G
L
H
N
R
R
Y
M
T
G
Q
L
D
S
L
V
K
R
A
T
L
G
G
D
P
V
S
A
L
L
I
D
I
D
F
F
K
K
I
N
D
T
F
G
H
D
I
G
D
E
V
L
R
E
F
A
L
R
L
A
S
N
V
-
R
A
I
D
L
P
C
R
Y
G
G
E
E
F
V
V
I
M
P
D
T
A
L
A
D
A
L
R
I
A
E
R
I
R
M
H
V
S
G
S
P
F
T
V
A
H
G
R
E
M
L
N
V
T
I
S
I
G
V
S
A
T
A
G
--
E
G
D
T
P
E
A
L
L
K
R
A
D
E
G
V
Y
Q
A
K
A
S
G
R
N
A
V
V
G
K
A
A
H
-------
25
PsiBlast_CBE
68.00
34%
-103
- C3 -
2V0N
6
PLED_CAUCN
B:
[155-448]
----------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
I
V
D
D
N
----
E
R
Q
A
Q
R
V
A
A
E
L
G
V
E
H
R
PV
I
E
S
D
P
E
K
A
K
I
S
A
G
G
P
V
D
L
V
I
V
-
N
A
A
A
K
N
F
D
G
L
R
F
T
A
A
L
R
S
E
E
R
T
R
Q
L
P
V
L
A
M
V
D
P
D
D
R
G
R
M
V
K
A
L
E
I
G
V
N
D
I
L
S
R
P
I
D
P
Q
E
L
S
A
R
V
K
T
Q
I
-------
Q
R
--------------------------------
K
--
R
-----------------------------
Y
------------------
T
D
Y
L
R
N
------------------------------------------------------
N
L
D
H
S
L
E
-------
L
A
V
T
D
Q
L
T
G
L
H
N
R
R
Y
M
T
G
Q
L
D
S
L
V
K
R
A
T
L
G
G
D
P
V
S
A
L
L
I
D
I
D
F
F
K
K
I
N
D
T
F
G
H
D
I
G
D
E
V
L
R
E
F
A
L
R
L
A
S
N
V
-
R
A
I
D
L
P
C
R
Y
G
G
E
E
F
V
V
I
M
P
D
T
A
L
A
D
A
L
R
I
A
E
R
I
R
M
H
V
S
G
S
P
F
T
V
A
H
G
R
E
M
L
N
V
T
I
S
I
G
V
S
A
--
T
A
G
E
G
D
T
P
E
A
L
L
K
R
A
D
E
G
V
Y
Q
A
K
A
S
G
R
N
A
V
-------------
6
PsiBlast_PDB
66.48
34%
-94
- C3 -
1W25
3
PLED_CAUCN
A:
[155-448]
----------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
I
V
D
D
N
----
E
R
Q
A
Q
R
V
A
A
E
L
G
V
E
H
R
P
V
I
E
S
D
P
E
K
A
K
I
S
A
G
G
P
V
D
L
V
I
V
-
N
A
A
A
K
N
F
D
G
L
R
F
T
A
A
L
R
S
E
E
R
T
R
Q
L
P
V
L
A
M
V
D
P
D
D
R
G
R
M
V
K
A
L
E
I
G
V
N
D
I
L
S
R
P
I
D
P
Q
E
L
S
A
R
V
K
T
Q
I
-------
Q
R
--------------------------------
K
--
R
-----------------------------
Y
------------------
T
D
Y
L
R
N
------------------------------------------------------
N
L
D
H
S
L
E
-------
L
A
V
T
D
Q
L
T
G
L
H
N
R
R
Y
M
T
G
Q
L
D
S
L
V
K
R
A
T
L
G
G
D
P
V
S
A
L
L
I
D
I
D
F
F
K
K
I
N
D
T
F
G
H
D
I
G
D
E
V
L
R
E
F
A
L
R
L
A
S
N
V
-
R
A
I
D
L
P
C
R
Y
G
G
E
E
F
V
V
I
M
P
D
T
A
L
A
D
A
L
R
I
A
E
R
I
R
M
H
V
S
G
S
P
F
T
V
A
H
G
R
E
M
L
N
V
T
I
S
I
G
V
S
A
--
T
A
G
E
G
D
T
P
E
A
L
L
K
R
A
D
E
G
V
Y
Q
A
K
A
S
G
R
N
A
V
-------------
3
PsiBlast_PDB
64.33
98%
-102
- C3 -
3I5C
5
GCN4_YEAST
A:
[26-196]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
K
L
V
N
S
D
G
L
T
G
L
S
N
R
R
H
F
D
E
Y
L
E
M
E
W
R
R
S
L
R
E
Q
S
Q
L
S
L
L
M
I
D
V
D
Y
F
K
S
Y
N
D
T
F
G
H
V
A
G
D
E
A
L
R
Q
V
A
G
A
I
R
E
G
C
S
R
S
S
D
L
A
A
R
Y
G
G
E
E
F
A
M
V
L
P
G
T
S
P
G
G
A
R
L
L
A
E
K
V
R
R
T
V
E
S
L
Q
I
S
H
D
Q
P
R
P
G
S
H
L
T
V
S
I
G
V
S
T
L
V
P
G
G
G
G
Q
T
F
R
V
L
I
E
M
A
D
Q
A
L
Y
Q
A
K
N
N
G
R
N
Q
V
G
L
M
----------
68
HHSearch
63.96
97%
-103
- C3 -
3I5C
5
GCN4_YEAST
A:
[23-196]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
L
K
K
L
V
N
S
D
G
L
T
G
L
S
N
R
R
H
F
D
E
Y
L
E
M
E
W
R
R
S
L
R
E
Q
S
Q
L
S
L
L
M
I
D
V
D
Y
F
K
S
Y
N
D
T
F
G
H
V
A
G
D
E
A
L
R
Q
V
A
G
A
I
R
E
G
C
S
R
S
S
D
L
A
A
R
Y
G
G
E
E
F
A
M
V
L
P
G
T
S
P
G
G
A
R
L
L
A
E
K
V
R
R
T
V
E
S
L
Q
I
S
H
D
Q
P
R
P
G
S
H
L
T
V
S
I
G
V
S
T
L
V
P
G
G
G
G
Q
T
F
R
V
L
I
E
M
A
D
Q
A
L
Y
Q
A
K
N
N
G
R
N
Q
V
G
L
M
----------
4
PsiBlast_PDB
63.68
100%
-101
- C3 -
3I5B
2
?
A:
[2-170]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
M
N
S
D
G
L
T
G
L
S
N
R
R
H
F
D
E
Y
L
E
M
E
W
R
R
S
L
R
E
Q
S
Q
L
S
L
L
M
I
D
V
D
Y
F
K
S
Y
N
D
T
F
G
H
V
A
G
D
E
A
L
R
Q
V
A
G
A
I
R
E
G
C
S
R
S
S
D
L
A
A
R
Y
G
G
E
E
F
A
M
V
L
P
G
T
S
P
G
G
A
R
L
L
A
E
K
V
R
R
T
V
E
S
L
Q
I
S
H
D
Q
P
R
P
G
S
H
L
T
V
S
I
G
V
S
T
L
V
P
G
G
G
G
Q
T
F
R
V
L
I
E
M
A
D
Q
A
L
Y
Q
A
K
N
N
G
R
N
Q
V
G
L
M
E
---------
22
PsiBlast_CBE
63.67
98%
-100
- C3 -
3I5C
4
GCN4_YEAST
B:
[26-198]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
K
L
V
N
S
D
G
L
T
G
L
S
N
R
R
H
F
D
E
Y
L
E
M
E
W
R
R
S
L
R
E
Q
S
Q
L
S
L
L
M
I
D
V
D
Y
F
K
S
Y
N
D
T
F
G
H
V
A
G
D
E
A
L
R
Q
V
A
G
A
I
R
E
G
C
S
R
S
S
D
L
A
A
R
Y
G
G
E
E
F
A
M
V
L
P
G
T
S
P
G
G
A
R
L
L
A
E
K
V
R
R
T
V
E
S
L
Q
I
S
H
D
Q
P
R
P
G
S
H
L
T
V
S
I
G
V
S
T
L
V
P
G
G
G
G
Q
T
F
R
V
L
I
E
M
A
D
Q
A
L
Y
Q
A
K
N
N
G
R
N
Q
V
G
L
M
E
Q
--------
23
PsiBlast_CBE
63.63
100%
-106
- C3 -
3I5B
1
?
B:
[2-169]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
M
N
S
D
G
L
T
G
L
S
N
R
R
H
F
D
E
Y
L
E
M
E
W
R
R
S
L
R
E
Q
S
Q
L
S
L
L
M
I
D
V
D
Y
F
K
S
Y
N
D
T
F
G
H
V
A
G
D
E
A
L
R
Q
V
A
G
A
I
R
E
G
C
S
R
S
S
D
L
A
A
R
Y
G
G
E
E
F
A
M
V
L
P
G
T
S
P
G
G
A
R
L
L
A
E
K
V
R
R
T
V
E
S
L
Q
I
S
H
D
Q
P
R
P
G
S
H
L
T
V
S
I
G
V
S
T
L
V
P
G
G
G
G
Q
T
F
R
V
L
I
E
M
A
D
Q
A
L
Y
Q
A
K
N
N
G
R
N
Q
V
G
L
M
----------
89
Fugue
63.28
30%
-87
- C3 -
1W25
4
PLED_CAUCN
A:
[1-454]
S
A
R
I
L
V
V
D
DI
E
A
N
V
R
L
L
E
A
K
L
T
A
E
Y
Y
E
V
S
T
A
MD
G
P
T
A
L
A
M
A
A
R
D
LPD
I
I
L
L
D
VMMPGMD
G
F
T
V
C
R
K
L
K
D
DPTTRH
I
P
V
V
L
I
T
A
LDG
R
G
D
R
I
Q
G
L
E
S
GAS
D
F
L
T
K
PID
D
V
M
L
F
A
R
V
R
S
L
T
R
F
K
L
V
I
D
E
L
R
Q
R
E
A
S
G
R
R
M
G
V
I
A
G
A
A
A
R
L
D
G
L
G
G
R
V
L
I
V
D
D
N
E
R
Q
A
Q
R
V
A
A
E
L
G
V
E
H
---
R
P
--
V
I
E
S
D
P
E
K
A
K
I
S
A
G
G
P
V
D
L
V
I
V
N
A
A
A
K
N
F
D
G
L
R
F
T
A
A
L
R
S
E
E
R
T
R
Q
L
P
V
L
A
M
V
D
P
D
D
R
G
R
M
V
K
A
L
E
I
G
V
N
D
I
L
S
R
P
I
D
P
Q
E
L
S
A
R
V
K
T
Q
I
Q
R
K
R
Y
T
D
Y
L
--------------------------------
R
--
N
-----------------------------
N
------------------
L
D
H
S
L
--------------------------------------------------------------------
E
L
A
V
T
D
Q
L
T
G
L
H
N
R
R
Y
M
T
G
Q
L
D
S
L
V
K
R
A
T
L
G
G
D
P
V
S
A
L
L
I
D
I
D
F
F
K
K
I
N
D
T
F
G
H
D
I
G
D
E
V
L
R
E
F
A
L
R
L
A
S
N
V
-
R
A
I
D
L
P
C
R
Y
G
G
E
E
F
V
V
I
M
P
D
T
A
L
A
D
A
L
R
I
A
E
R
I
R
M
H
V
S
G
S
P
F
T
V
A
H
G
R
E
M
L
N
V
T
I
S
I
G
V
S
A
T
--
A
G
E
G
D
T
P
E
A
L
L
K
R
A
D
E
G
V
Y
Q
A
K
A
S
G
R
N
A
V
V
G
-------
K
A
A
H
72
HHSearch
51.21
39%
-88
- C3 -
3IGN
2
?
A:
[5-170]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
L
S
M
T
D
R
L
T
G
L
L
N
R
G
T
W
E
N
L
V
D
A
E
Y
E
R
F
R
R
Y
G
Q
A
T
S
L
V
M
F
D
I
D
H
F
K
P
V
N
D
T
Y
G
H
L
A
G
D
E
V
I
R
H
T
A
D
V
T
R
N
N
I
-
R
Q
S
D
S
A
G
R
Y
G
G
E
E
F
G
I
I
L
P
E
T
D
A
E
S
A
R
V
I
C
E
R
I
R
E
A
I
E
K
S
T
V
S
T
--
S
A
G
D
I
Q
Y
T
V
S
M
G
I
A
Q
L
T
E
--
T
P
E
N
Y
M
Q
W
M
Q
K
A
D
E
A
L
Y
K
A
K
E
S
G
R
N
K
V
V
V
S
L
---------
8
PsiBlast_PDB
49.85
39%
-88
- C3 -
3IGN
2
?
A:
[5-166]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
L
S
M
T
D
R
L
T
G
L
L
N
R
G
T
W
E
N
L
V
D
A
E
Y
E
R
F
R
R
Y
G
Q
A
T
S
L
V
M
F
D
I
D
H
F
K
P
V
N
D
T
Y
G
H
L
A
G
D
E
V
I
R
H
T
A
D
V
T
R
N
N
I
-
R
Q
S
D
S
A
G
R
Y
G
G
E
E
F
G
I
I
L
P
E
T
D
A
E
S
A
R
V
I
C
E
R
I
R
E
A
I
E
K
S
T
V
S
--
T
S
A
G
D
I
Q
Y
T
V
S
M
G
I
A
Q
L
T
E
--
T
P
E
N
Y
M
Q
W
M
Q
K
A
D
E
A
L
Y
K
A
K
E
S
G
R
N
K
V
-------------
9
PsiBlast_PDB
49.81
33%
-91
- C3 -
3TVK
5
YDEH_ECOLI
A:
[5-164]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
M
D
V
L
T
G
L
P
G
R
R
V
L
D
E
S
F
D
H
Q
L
R
N
A
--
E
P
L
N
L
Y
L
M
L
L
D
I
D
R
F
K
L
V
N
D
T
Y
G
H
L
I
G
D
V
V
L
R
T
L
A
T
Y
L
-
A
S
W
T
R
D
Y
E
T
V
Y
R
Y
G
G
E
E
F
I
I
I
V
K
A
A
N
D
E
E
A
C
R
A
G
V
R
I
C
Q
L
V
D
N
H
A
I
T
H
S
E
G
H
I
--
N
I
T
V
T
A
G
V
S
R
A
F
P
---
E
E
P
L
D
V
V
I
G
R
A
D
R
A
M
Y
E
G
K
Q
T
G
R
N
R
C
M
F
I
D
E
--------
49
PsiBlast_CBE
49.70
34%
-126
- C3 -
4L85
9
KDPE_ECOLI
A:
[6-121]
----------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
I
V
E
D
E
Q
A
I
R
R
F
L
R
T
A
L
E
G
D
-
G
M
R
V
F
--
E
A
E
T
L
Q
R
G
L
L
E
A
A
T
R
K
P
D
L
I
I
L
A
L
G
-----
G
I
E
F
I
R
D
L
R
Q
W
S
A
---
V
P
V
I
V
L
S
A
R
S
E
E
S
D
K
I
A
A
L
D
A
G
A
D
D
Y
L
S
K
P
F
G
I
G
E
L
Q
A
R
L
R
V
A
L
R
R
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------