@TOME V2.3
(Nov 2016)
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF00194_CAH5A_: (2014-08-31 )
MLRRDPRKPLAILRHVGLLCATGPQRWRFQHSCAEEHSNCARHPLWTGPVSSAEGTRQSPINIQWKDSVYDPQLAPLRVSYDAASCRYLWNTGYFFQVEFDDSCEDSGISGGPLGNHYRLKQFHFHWGATDEWGSEHAVDGHTYPAELHLVHWNSTKYENYKKASVGENGLAVIGVFLKLGAHHQALQKLVDVLPEVRHKDTQVAMGPFDPSCLLPACRDYWTYPGSLTTPPLAESVTWIVQKTPVEVSPSQLSTFRTLLFSGRGEEEDVMVNNYRPLQPLRDRKLRSSFRLDRTKMRS
Atome Classification :
(24 SA)
.........10........20........30--.----.......40........50---........60........70........---80.--...--.....90........100.......110.......120......-.130.-.......140.......150.......160.......170.......180.-.-......190.......200.......210.....-.---.220.......230.......240.......250.......260.--.--.....270.......280.......290.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MLRRDPR
K
P
L
A
I
L
R
HVG
L
L
CATGPQ
R
W
R
F
Q
H
--
S
----
C
A
E
E
HSNCARHPLWTGPVS---SAEGTRQS
P
I
N
I
Q
WKDSVYDPQLA
P
L
R
V
---
S
-Y--DAA--
S
C
R
Y
L
WNT
G
Y
F
F
Q
V
E
FDDSCEDSGISGGPLGN
H
Y
R
L
K
Q
F
H
F
HWG-ATD-E-WGSEHAVDGHTY
P
A
E
L
H
L
V
HWNSTKYENYKKASVGEN
G
L
A
V
I
G
V
F
L
K
LG-
A
-
H
-
H
Q
A
L
Q
K
L
V
D
V
L
P
E
VRHKDT
Q
V
AMGPF
D
P
S
C
L
L
P
A
-
C
---
R
DYWTYPGSLTTP
P
L
A
E
S
V
T
W
I
V
QKTPVEV
S
P
S
Q
L
S
T
F
R
T
L
L
FSG--R--GEEE
D
V
M
VNNYRPLQ
P
L
R
D
R
K
L
R
S
S
FRL
D
R
T
KMRS
37
HHSearch
98.39
98%
-99
- C3 -
1KEQ
5
CAH5A_MOUSE
A:
[4-241]
---------------------------------------------------------------
G
T
R
Q
S
P
I
N
I
Q
W
K
D
S
V
Y
D
P
Q
L
A
P
L
R
V
---
S
-
Y
--
D
A
A
--
S
C
R
Y
L
W
N
T
G
Y
A
F
Q
V
E
F
D
D
S
C
E
D
S
G
I
S
G
G
P
L
G
N
H
Y
R
L
K
Q
F
H
F
H
W
G
-
A
T
D
-
E
-
W
G
S
E
H
A
V
D
G
H
T
Y
P
A
E
L
H
L
V
H
W
N
S
T
K
Y
E
N
C
K
K
A
S
V
G
E
N
G
L
A
V
I
G
V
F
L
K
L
G
-
A
-
H
-
H
Q
A
L
Q
K
L
V
D
V
L
P
E
V
R
H
K
D
T
Q
V
A
M
G
P
F
D
P
S
C
L
M
P
A
-
C
---
R
D
Y
W
T
Y
P
G
S
L
T
T
P
P
L
A
E
S
V
T
W
I
V
Q
K
T
P
V
E
V
S
P
S
Q
L
S
M
F
R
T
L
L
F
S
G
--
R
--
G
E
E
E
D
V
M
V
N
N
Y
R
P
L
Q
P
L
R
D
R
K
L
R
S
S
F
R
L
-------
21
PsiBlast_CBE
97.76
98%
-102
- C3 -
1DMY
1
CAH5A_MOUSE
B:
[4-240]
---------------------------------------------------------------
G
T
R
Q
S
P
I
N
I
Q
W
K
D
S
V
Y
D
P
Q
L
A
P
L
R
V
---
S
-
Y
--
D
A
A
--
S
C
R
Y
L
W
N
T
G
Y
F
F
Q
V
E
F
D
D
S
C
E
D
S
G
I
S
G
G
P
L
G
N
H
Y
R
L
K
Q
F
H
F
H
W
G
-
A
T
D
-
E
-
W
G
S
E
H
A
V
D
G
H
T
Y
P
A
E
L
H
L
V
H
W
N
S
T
K
Y
E
N
Y
K
K
A
S
V
G
E
N
G
L
A
V
I
G
V
F
L
K
L
G
-
A
-
H
-
H
Q
A
L
Q
K
L
V
D
V
L
P
E
V
R
H
K
D
T
Q
V
A
M
G
P
F
D
P
S
C
L
M
P
A
-
C
---
R
D
Y
W
T
Y
P
G
S
L
T
T
P
P
L
A
E
S
V
T
W
I
V
Q
K
T
P
V
E
V
S
P
S
Q
L
S
M
F
R
T
L
L
F
S
G
--
R
--
G
E
E
E
D
V
M
V
N
N
Y
R
P
L
Q
P
L
R
D
R
K
L
R
S
S
F
R
--------
2
PsiBlast_PDB
97.55
98%
-99
- C3 -
1DMY
1
CAH5A_MOUSE
A:
[4-240]
---------------------------------------------------------------
G
T
R
Q
S
P
I
N
I
Q
W
K
D
S
V
Y
D
P
Q
L
A
P
L
R
V
---
S
-
Y
--
D
A
A
--
S
C
R
Y
L
W
N
T
G
Y
F
F
Q
V
E
F
D
D
S
C
E
D
S
G
I
S
G
G
P
L
G
N
H
Y
R
L
K
Q
F
H
F
H
W
G
-
A
T
D
-
E
-
W
G
S
E
H
A
V
D
G
H
T
Y
P
A
E
L
H
L
V
H
W
N
S
T
K
Y
E
N
Y
K
K
A
S
V
G
E
N
G
L
A
V
I
G
V
F
L
K
L
G
-
A
-
H
-
H
Q
A
L
Q
K
L
V
D
V
L
P
E
V
R
H
K
D
T
Q
V
A
M
G
P
F
D
P
S
C
L
M
P
A
-
C
---
R
D
Y
W
T
Y
P
G
S
L
T
T
P
P
L
A
E
S
V
T
W
I
V
Q
K
T
P
V
E
V
S
P
S
Q
L
S
M
F
R
T
L
L
F
S
G
--
R
--
G
E
E
E
D
V
M
V
N
N
Y
R
P
L
Q
P
L
R
D
R
K
L
R
S
S
F
R
--------
23
PsiBlast_CBE
97.54
97%
-99
- C3 -
1KEQ
3
CAH5A_MOUSE
B:
[4-241]
---------------------------------------------------------------
G
T
R
Q
S
P
I
N
I
Q
W
K
D
S
V
Y
D
P
Q
L
A
P
L
R
V
---
S
-
Y
--
D
A
A
--
S
C
R
Y
L
W
N
T
G
Y
A
F
Q
V
E
F
D
D
S
C
E
D
S
G
I
S
G
G
P
L
G
N
H
Y
R
L
K
Q
F
H
F
H
W
G
-
A
T
D
-
E
-
W
G
S
E
H
A
V
D
G
H
T
Y
P
A
E
L
H
L
V
H
W
N
S
T
K
Y
E
N
C
K
K
A
S
V
G
E
N
G
L
A
V
I
G
V
F
L
K
L
G
-
A
-
H
-
H
Q
A
L
Q
K
L
V
D
V
L
P
E
V
R
H
K
D
T
Q
V
A
M
G
P
F
D
P
S
C
L
M
P
A
-
C
---
R
D
Y
W
T
Y
P
G
S
L
T
T
P
P
L
A
E
S
V
T
W
I
V
Q
K
T
P
V
E
V
S
P
S
Q
L
S
M
F
R
T
L
L
F
S
G
--
R
--
G
E
E
E
D
V
M
V
N
N
Y
R
P
L
Q
P
L
R
D
R
K
L
R
S
S
F
R
L
-------
36
HHSearch
87.27
49%
-83
- C3 -
3ML5
1
CAH7_HUMAN
A:
[9-269]
-----------------------
H
H
G
W
G
Y
G
Q
--
D
----
D
G
P
S
H
--------
W
H
K
L
Y
P
---
I
A
Q
G
D
R
Q
S
P
I
N
I
I
S
S
Q
A
V
Y
S
P
S
L
Q
P
L
E
L
---
S
-
Y
--
E
A
C
--
M
S
L
S
I
T
N
N
G
H
S
V
Q
V
D
F
N
D
S
D
D
R
T
V
V
T
G
G
P
L
E
G
P
Y
R
L
K
Q
F
H
F
H
W
G
-
K
K
H
-
D
-
V
G
S
E
H
T
V
D
G
K
S
F
P
S
E
L
H
L
V
H
W
N
A
K
K
Y
S
T
F
G
E
A
A
S
A
P
D
G
L
A
V
V
G
V
F
L
E
T
G
-
D
-
E
-
H
P
S
M
N
R
L
T
D
A
L
Y
M
V
R
F
K
G
T
K
A
Q
F
S
C
F
N
P
K
S
L
L
P
A
-
S
---
R
H
Y
W
T
Y
P
G
S
L
T
T
P
P
L
S
E
S
V
T
W
I
V
L
R
E
P
I
S
I
S
E
R
Q
M
G
K
F
R
S
L
L
F
T
S
--
E
--
D
D
E
R
I
H
M
V
N
N
F
R
P
P
Q
P
L
K
G
R
V
V
K
A
S
F
R
A
-------
12
PsiBlast_PDB
86.83
53%
-89
- C3 -
3DCC
1
CAH2_HUMAN
A:
[16-260]
---------------------------------------------------
W
H
K
D
F
P
---
I
A
K
G
E
R
Q
S
P
V
D
I
D
T
H
T
A
K
Y
D
P
S
L
K
P
L
S
V
---
S
-
Y
--
D
Q
A
--
T
S
L
R
I
L
N
N
G
H
S
F
Q
V
E
F
D
D
S
Q
D
K
A
V
L
K
G
G
P
L
D
G
T
Y
R
L
I
Q
F
H
F
H
W
G
-
S
L
D
-
G
-
Q
G
S
E
H
T
V
D
K
K
K
Y
A
A
E
L
H
L
V
H
W
N
-
T
K
Y
G
D
F
G
K
A
V
Q
Q
P
D
G
L
A
V
L
G
I
F
L
K
V
G
-
S
-
A
-
K
P
G
L
Q
K
V
V
D
V
L
D
S
I
K
T
K
G
K
S
A
D
F
T
N
F
D
P
R
G
L
L
P
E
-
S
---
L
D
Y
W
T
Y
P
G
S
L
T
T
P
P
L
L
E
C
V
T
W
I
V
L
K
E
P
I
S
V
S
S
E
Q
V
L
K
F
R
K
L
N
F
N
G
--
E
--
G
E
P
E
E
L
M
V
D
N
W
R
P
A
Q
P
L
K
N
R
Q
I
K
A
S
F
K
--------
10
PsiBlast_PDB
86.65
53%
-92
- C3 -
3DC3
1
CAH2_HUMAN
A:
[16-260]
---------------------------------------------------
W
H
K
D
F
P
---
I
A
K
G
E
R
Q
S
P
V
D
I
D
T
H
T
A
K
Y
D
P
S
L
K
P
L
S
V
---
S
-
Y
--
D
Q
A
--
T
S
L
R
I
L
N
N
G
H
S
F
Q
V
E
F
D
D
S
Q
D
K
A
V
L
K
G
G
P
L
D
G
T
Y
R
L
I
Q
F
H
F
H
W
G
-
S
L
D
-
G
-
Q
G
S
E
H
T
V
D
K
K
K
Y
A
A
E
L
H
L
V
H
W
N
-
T
K
Y
G
D
F
G
K
A
V
Q
Q
P
D
G
L
A
V
L
G
I
F
L
K
V
G
-
S
-
A
-
K
P
G
L
Q
K
V
V
D
V
L
D
S
I
K
T
K
G
K
S
A
D
F
T
N
F
D
P
R
G
L
L
P
E
-
S
---
L
D
Y
W
T
Y
P
G
S
L
T
T
P
P
L
L
E
C
V
T
W
I
V
L
K
E
P
I
S
V
S
S
E
Q
V
L
K
F
R
K
L
N
F
N
G
--
E
--
G
E
P
E
E
L
M
V
D
N
W
R
P
A
Q
P
L
K
N
R
Q
I
K
A
S
F
K
--------
13
PsiBlast_PDB
86.42
53%
-91
- C3 -
3DCS
1
CAH2_HUMAN
A:
[16-260]
---------------------------------------------------
W
H
K
D
F
P
---
I
A
K
G
E
R
Q
S
P
V
D
I
D
T
H
T
A
K
Y
D
P
S
L
K
P
L
S
V
---
S
-
Y
--
D
Q
A
--
T
S
L
R
I
L
N
N
G
H
S
F
Q
V
E
F
D
D
S
Q
D
K
A
V
L
K
G
G
P
L
D
G
T
Y
R
L
I
Q
F
H
F
H
W
G
-
S
L
D
-
G
-
Q
G
S
E
H
T
V
D
K
K
K
Y
A
A
E
L
H
L
V
H
W
N
-
T
K
Y
G
D
F
G
K
A
V
Q
Q
P
D
G
L
A
V
L
G
I
F
L
K
V
G
-
S
-
A
-
K
P
G
L
Q
K
V
V
D
V
L
D
S
I
K
T
K
G
K
S
A
D
F
T
N
F
D
P
R
G
L
L
P
E
-
S
---
L
D
Y
W
T
Y
P
G
S
L
T
T
P
P
L
L
E
C
V
T
W
I
V
L
K
E
P
I
S
V
S
S
E
Q
V
L
K
F
R
K
L
N
F
N
G
--
E
--
G
E
P
E
E
L
M
V
D
N
W
R
P
A
Q
P
L
K
N
R
Q
I
K
A
S
F
K
--------
17
PsiBlast_PDB
86.24
53%
-88
- C3 -
3OKV
3
CAH2_HUMAN
A:
[16-260]
---------------------------------------------------
W
H
K
D
F
P
---
I
A
K
G
E
R
Q
S
P
V
D
I
D
T
H
T
A
K
Y
D
P
S
L
K
P
L
S
V
---
S
-
Y
--
D
Q
A
--
T
S
L
R
I
L
N
N
G
H
S
F
Q
V
E
F
D
D
S
Q
D
K
A
V
L
K
G
G
P
L
D
G
T
Y
R
L
I
Q
F
H
F
H
W
G
-
S
L
D
-
G
-
Q
G
S
E
H
T
V
D
K
K
K
Y
A
A
E
L
H
L
V
H
W
N
-
T
K
Y
G
D
F
G
K
A
V
Q
Q
P
D
G
L
A
V
L
G
I
F
L
K
V
G
-
S
-
A
-
K
P
G
L
Q
K
V
V
D
V
L
D
S
I
K
T
K
G
K
S
A
D
F
T
N
F
D
P
R
G
L
L
P
E
-
S
---
L
D
Y
W
T
Y
P
G
S
L
T
T
P
P
L
L
E
C
V
T
W
I
V
L
K
E
P
I
S
V
S
S
E
Q
V
L
K
F
R
K
L
N
F
N
G
--
E
--
G
E
P
E
E
L
M
V
D
N
W
R
P
A
Q
P
L
K
N
R
Q
I
K
A
S
F
K
--------
15
PsiBlast_PDB
86.24
53%
-88
- C3 -
3OIK
2
CAH2_HUMAN
A:
[16-260]
---------------------------------------------------
W
H
K
D
F
P
---
I
A
K
G
E
R
Q
S
P
V
D
I
D
T
H
T
A
K
Y
D
P
S
L
K
P
L
S
V
---
S
-
Y
--
D
Q
A
--
T
S
L
R
I
L
N
N
G
H
S
F
Q
V
E
F
D
D
S
Q
D
K
A
V
L
K
G
G
P
L
D
G
T
Y
R
L
I
Q
F
H
F
H
W
G
-
S
L
D
-
G
-
Q
G
S
E
H
T
V
D
K
K
K
Y
A
A
E
L
H
L
V
H
W
N
-
T
K
Y
G
D
F
G
K
A
V
Q
Q
P
D
G
L
A
V
L
G
I
F
L
K
V
G
-
S
-
A
-
K
P
G
L
Q
K
V
V
D
V
L
D
S
I
K
T
K
G
K
S
A
D
F
T
N
F
D
P
R
G
L
L
P
E
-
S
---
L
D
Y
W
T
Y
P
G
S
L
T
T
P
P
L
L
E
C
V
T
W
I
V
L
K
E
P
I
S
V
S
S
E
Q
V
L
K
F
R
K
L
N
F
N
G
--
E
--
G
E
P
E
E
L
M
V
D
N
W
R
P
A
Q
P
L
K
N
R
Q
I
K
A
S
F
K
--------
18
PsiBlast_PDB
86.16
53%
-88
- C3 -
4BCW
1
CAH2_HUMAN
A:
[13-257]
---------------------------------------------------
W
H
K
D
F
P
---
I
A
K
G
E
R
Q
S
P
V
D
I
D
T
H
T
A
K
Y
D
P
S
L
K
P
L
S
V
---
S
-
Y
--
D
Q
A
--
T
S
L
R
I
L
N
N
G
H
S
F
Q
V
E
F
D
D
S
Q
D
K
A
V
L
K
G
G
P
L
D
G
T
Y
R
L
I
Q
F
H
F
H
W
G
-
S
L
D
-
G
-
Q
G
S
E
H
T
V
D
K
K
K
Y
A
A
E
L
H
L
V
H
W
N
-
T
K
Y
G
D
F
G
K
A
V
Q
Q
P
D
G
L
A
V
L
G
I
F
L
K
V
G
-
S
-
A
-
K
P
G
L
Q
K
V
V
D
V
L
D
S
I
K
T
K
G
K
S
A
D
F
T
N
F
D
P
R
G
L
L
P
E
-
S
---
L
D
Y
W
T
Y
P
G
S
L
T
T
P
P
L
L
E
C
V
T
W
I
V
L
K
E
P
I
S
V
S
S
E
Q
V
L
K
F
R
K
L
N
F
N
G
--
E
--
G
E
P
E
E
L
M
V
D
N
W
R
P
A
Q
P
L
K
N
R
Q
I
K
A
S
F
K
--------
16
PsiBlast_PDB
86.08
53%
-89
- C3 -
3OIL
1
CAH2_HUMAN
A:
[16-260]
---------------------------------------------------
W
H
K
D
F
P
---
I
A
K
G
E
R
Q
S
P
V
D
I
D
T
H
T
A
K
Y
D
P
S
L
K
P
L
S
V
---
S
-
Y
--
D
Q
A
--
T
S
L
R
I
L
N
N
G
H
S
F
Q
V
E
F
D
D
S
Q
D
K
A
V
L
K
G
G
P
L
D
G
T
Y
R
L
I
Q
F
H
F
H
W
G
-
S
L
D
-
G
-
Q
G
S
E
H
T
V
D
K
K
K
Y
A
A
E
L
H
L
V
H
W
N
-
T
K
Y
G
D
F
G
K
A
V
Q
Q
P
D
G
L
A
V
L
G
I
F
L
K
V
G
-
S
-
A
-
K
P
G
L
Q
K
V
V
D
V
L
D
S
I
K
T
K
G
K
S
A
D
F
T
N
F
D
P
R
G
L
L
P
E
-
S
---
L
D
Y
W
T
Y
P
G
S
L
T
T
P
P
L
L
E
C
V
T
W
I
V
L
K
E
P
I
S
V
S
S
E
Q
V
L
K
F
R
K
L
N
F
N
G
--
E
--
G
E
P
E
E
L
M
V
D
N
W
R
P
A
Q
P
L
K
N
R
Q
I
K
A
S
F
K
--------
14
PsiBlast_PDB
86.04
53%
-88
- C3 -
3DCW
1
CAH2_HUMAN
A:
[16-260]
---------------------------------------------------
W
H
K
D
F
P
---
I
A
K
G
E
R
Q
S
P
V
D
I
D
T
H
T
A
K
Y
D
P
S
L
K
P
L
S
V
---
S
-
Y
--
D
Q
A
--
T
S
L
R
I
L
N
N
G
H
S
F
Q
V
E
F
D
D
S
Q
D
K
A
V
L
K
G
G
P
L
D
G
T
Y
R
L
I
Q
F
H
F
H
W
G
-
S
L
D
-
G
-
Q
G
S
E
H
T
V
D
K
K
K
Y
A
A
E
L
H
L
V
H
W
N
-
T
K
Y
G
D
F
G
K
A
V
Q
Q
P
D
G
L
A
V
L
G
I
F
L
K
V
G
-
S
-
A
-
K
P
G
L
Q
K
V
V
D
V
L
D
S
I
K
T
K
G
K
S
A
D
F
T
N
F
D
P
R
G
L
L
P
E
-
S
---
L
D
Y
W
T
Y
P
G
S
L
T
T
P
P
L
L
E
C
V
T
W
I
V
L
K
E
P
I
S
V
S
S
E
Q
V
L
K
F
R
K
L
N
F
N
G
--
E
--
G
E
P
E
E
L
M
V
D
N
W
R
P
A
Q
P
L
K
N
R
Q
I
K
A
S
F
K
--------
9
PsiBlast_PDB
85.76
53%
-90
- C3 -
3DBU
1
CAH2_HUMAN
A:
[16-260]
---------------------------------------------------
W
H
K
D
F
P
---
I
A
K
G
E
R
Q
S
P
V
D
I
D
T
H
T
A
K
Y
D
P
S
L
K
P
L
S
V
---
S
-
Y
--
D
Q
A
--
T
S
L
R
I
L
N
N
G
H
S
F
Q
V
E
F
D
D
S
Q
D
K
A
V
L
K
G
G
P
L
D
G
T
Y
R
L
I
Q
F
H
F
H
W
G
-
S
L
D
-
G
-
Q
G
S
E
H
T
V
D
K
K
K
Y
A
A
E
L
H
L
V
H
W
N
-
T
K
Y
G
D
F
G
K
A
V
Q
Q
P
D
G
L
A
V
L
G
I
F
L
K
V
G
-
S
-
A
-
K
P
G
L
Q
K
V
V
D
V
L
D
S
I
K
T
K
G
K
S
A
D
F
T
N
F
D
P
R
G
L
L
P
E
-
S
---
L
D
Y
W
T
Y
P
G
S
L
T
T
P
P
L
L
E
C
V
T
W
I
V
L
K
E
P
I
S
V
S
S
E
Q
V
L
K
F
R
K
L
N
F
N
G
--
E
--
G
E
P
E
E
L
M
V
D
N
W
R
P
A
Q
P
L
K
N
R
Q
I
K
A
S
F
K
--------
35
HHSearch
85.60
52%
-85
- C3 -
3K34
5
CAH2_HUMAN
A:
[3-260]
------------------------
H
H
W
G
Y
G
K
--
H
----
N
G
P
E
H
--------
W
H
K
D
F
P
---
I
A
K
G
E
R
Q
S
P
V
D
I
D
T
H
T
A
K
Y
D
P
S
L
K
P
L
S
V
---
S
-
Y
--
D
Q
A
--
T
S
L
R
I
L
N
N
G
H
A
F
N
V
E
F
D
D
S
Q
D
K
A
V
L
K
G
G
P
L
D
G
T
Y
R
L
I
Q
F
H
F
H
W
G
-
S
L
D
-
G
-
Q
G
S
E
H
T
V
D
K
K
K
Y
A
A
E
L
H
L
V
H
W
N
-
T
K
Y
G
D
F
G
K
A
V
Q
Q
P
D
G
L
A
V
L
G
I
F
L
K
V
G
-
S
-
A
-
K
P
G
L
Q
K
V
V
D
V
L
D
S
I
K
T
K
G
K
S
A
D
F
T
N
F
D
P
R
G
L
L
P
E
-
S
---
L
D
Y
W
T
Y
P
G
S
L
T
T
P
P
L
L
E
C
V
T
W
I
V
L
K
E
P
I
S
V
S
S
E
Q
V
L
K
F
R
K
L
N
F
N
G
--
E
--
G
E
P
E
E
L
M
V
D
N
W
R
P
A
Q
P
L
K
N
R
Q
I
K
A
S
F
K
--------
7
PsiBlast_PDB
85.11
51%
-89
- C3 -
3TVO
1
CAH2_HUMAN
X:
[3-258]
--------------------------
W
G
F
G
K
--
H
----
N
G
P
E
H
--------
W
H
K
D
F
P
---
I
A
K
G
E
R
Q
S
P
V
D
I
D
T
H
T
A
K
Y
D
P
S
L
K
P
L
S
V
---
S
-
Y
--
D
Q
A
--
T
S
L
R
I
L
N
N
G
H
A
F
Q
V
E
F
D
D
S
Q
D
K
A
V
L
K
G
G
P
L
D
G
T
Y
R
L
I
Q
F
H
F
H
W
G
-
S
L
D
-
G
-
Q
G
S
E
H
T
V
D
K
K
K
Y
A
A
E
L
H
L
V
H
W
N
-
T
K
Y
G
D
F
G
K
A
V
Q
Q
P
D
G
L
A
V
L
G
I
F
L
K
V
G
-
S
-
A
-
K
P
G
L
Q
K
V
V
D
V
L
D
S
I
K
T
K
G
K
S
A
D
F
T
N
F
D
P
R
G
L
L
P
E
-
S
---
L
D
Y
W
T
Y
P
G
S
L
T
T
P
P
L
L
E
C
V
T
W
I
V
L
K
E
P
I
S
V
S
S
E
Q
V
L
K
F
R
K
L
N
F
N
G
--
E
--
G
E
P
E
E
L
M
V
D
N
W
R
P
A
Q
P
L
K
N
R
Q
I
K
A
S
F
K
--------
32
HHSearch
84.37
48%
-77
- C3 -
4KNN
7
CAH13_HUMAN
B:
[6-263]
-------------------------
S
W
G
Y
R
E
--
H
----
N
G
P
I
H
--------
W
K
E
F
F
P
---
I
A
D
G
D
Q
Q
S
P
I
E
I
K
T
K
E
V
K
Y
D
S
S
L
R
P
L
S
I
---
K
-
Y
--
D
P
S
--
S
A
K
I
I
S
N
S
G
H
S
F
N
V
D
F
D
D
T
E
N
K
S
V
L
R
G
G
P
L
T
G
S
Y
R
L
R
Q
V
H
L
H
W
G
-
S
A
D
-
D
-
H
G
S
E
H
I
V
D
G
V
S
Y
A
A
E
L
H
V
V
H
W
N
S
D
K
Y
P
S
F
V
E
A
A
H
E
P
D
G
L
A
V
L
G
V
F
L
Q
I
G
-
E
-
P
-
N
S
Q
L
Q
K
I
T
D
T
L
D
S
I
K
E
K
G
K
Q
T
R
F
T
N
F
D
L
L
S
L
L
P
P
-
S
---
W
D
Y
W
T
Y
P
G
S
L
T
V
P
P
L
L
E
S
V
T
W
I
V
L
K
Q
P
I
N
I
S
S
Q
Q
L
A
K
F
R
S
L
L
C
T
A
--
E
--
G
E
A
A
A
F
L
V
S
N
H
R
P
P
Q
P
L
K
G
R
K
V
R
A
S
F
H
--------
33
HHSearch
82.20
46%
-79
* C3 *
2FOY
3
CAH1_HUMAN
A:
[5-260]
--------------------------
W
G
Y
D
D
--
K
----
N
G
P
E
Q
--------
W
S
K
L
Y
P
---
I
A
N
G
N
N
Q
S
P
V
D
I
K
T
S
E
T
K
H
D
T
S
L
K
P
I
S
V
---
S
-
Y
--
N
P
A
--
T
A
K
E
I
I
N
V
G
H
S
F
H
V
N
F
E
D
N
D
N
R
S
V
L
K
G
G
P
F
S
D
S
Y
R
L
F
Q
F
H
F
H
W
G
-
S
T
N
-
E
-
H
G
S
E
H
T
V
D
G
V
K
Y
S
A
E
L
H
V
A
H
W
N
S
A
K
Y
S
S
L
A
E
A
A
S
K
A
D
G
L
A
V
I
G
V
L
M
K
V
G
-
E
-
A
-
N
P
K
L
Q
K
V
L
D
A
L
Q
A
I
K
T
K
G
K
R
A
P
F
T
N
F
D
P
S
T
L
L
P
S
-
S
---
L
D
F
W
T
Y
P
G
S
L
T
H
P
P
L
Y
E
S
V
T
W
I
I
C
K
E
S
I
S
V
S
S
E
Q
L
A
Q
F
R
S
L
L
S
N
V
--
E
--
G
D
N
A
V
P
M
Q
H
N
N
R
P
T
Q
P
L
K
G
R
T
V
R
A
S
F
---------
41
HHSearch
80.59
35%
-83
- C3 -
4LU3
6
CAH14_HUMAN
A:
[21-282]
-------------------------
H
W
T
Y
E
G
--
P
----
H
G
Q
D
H
--------
W
P
A
S
Y
P
---
E
C
G
N
N
A
Q
S
P
I
D
I
Q
T
D
S
V
T
F
D
P
D
L
P
A
L
Q
P
---
H
G
Y
--
D
Q
P
GT
E
P
L
D
L
H
N
N
G
H
T
V
Q
L
S
L
P
S
T
---
L
Y
L
--
G
G
L
P
R
K
Y
V
A
A
Q
L
H
L
H
W
G
-
Q
K
G
S
P
-
G
G
S
E
H
Q
I
N
S
E
A
T
F
A
E
L
H
I
V
H
Y
D
S
D
S
Y
D
S
L
S
E
A
A
E
R
P
Q
G
L
A
V
L
G
I
L
I
E
V
G
-
E
-
T
K
N
I
A
Y
E
H
I
L
S
H
L
H
E
V
R
H
K
D
Q
K
T
S
V
P
P
F
N
L
R
E
L
L
P
K
-
Q
L--
G
Q
Y
F
R
Y
N
G
S
L
T
T
P
P
C
Y
Q
S
V
L
W
T
V
F
Y
R
R
S
Q
I
S
M
E
Q
L
E
K
L
Q
G
T
L
F
S
T
--
E
--
E
E
P
S
K
L
L
V
Q
N
Y
R
A
L
Q
P
L
N
Q
R
M
V
F
A
S
F
I
Q
A
G
-----
25
Fugue
77.06
33%
-91
- C3 -
1JD0
1
CAH12_HUMAN
A:
[3-262]
-------------------------
K
W
T
Y
F
G
--
P
------------
D
G
E
N
S
W
S
K
K
Y
P
---
S
C
G
G
L
L
Q
S
P
I
D
L
H
S
D
I
L
Q
Y
D
A
S
L
T
P
L
E
F
Q
GY
N
-
L
--
S
A
N
--
K
Q
F
L
L
T
N
N
G
H
S
V
K
L
N
L
P
-----
S
D
M
H
I
Q
G
L
Q
S
R
Y
S
A
T
Q
L
H
L
H
W
G
N
P
N
D
-
P
-
H
G
S
E
H
T
V
S
G
Q
H
F
A
A
E
L
H
I
V
H
Y
N
S
D
L
Y
P
D
A
S
T
A
S
N
K
S
E
G
L
A
V
L
A
V
L
I
E
M
G
-
S
-
F
-
N
P
S
Y
D
K
I
F
S
H
L
Q
H
V
K
Y
K
G
Q
E
A
F
V
P
G
F
N
I
E
E
L
L
P
E
R
T
---
A
E
Y
Y
R
Y
R
G
S
L
T
T
P
P
C
N
P
T
V
L
W
T
V
F
R
N
P
V
Q
I
S
Q
E
Q
L
L
A
L
E
T
A
L
Y
C
T
HM
D
--
D
P
S
P
R
E
M
I
N
N
F
R
Q
V
Q
K
F
D
E
R
L
V
Y
T
S
F
S
--------
39
HHSearch
76.90
33%
-86
- C3 -
4HT2
4
CAH12_HUMAN
A:
[3-263]
-------------------------
K
W
T
Y
F
G
--
P
----
D
G
E
N
S
--------
W
S
K
K
Y
P
---
S
C
G
G
L
L
Q
S
P
I
D
L
H
S
D
I
L
Q
Y
D
A
S
L
T
P
L
E
F
---
Q
G
Y
--
N
L
S
AN
K
Q
F
L
L
T
N
N
G
H
S
V
K
L
N
L
P
S
D
---
M
H
I
Q
G
--
L
Q
S
R
Y
S
A
T
Q
L
H
L
H
W
G
-
N
P
N
-
D
P
H
G
S
E
H
T
V
S
G
Q
H
F
A
A
E
L
H
I
V
H
Y
N
S
D
L
Y
P
D
A
S
T
A
S
N
K
S
E
G
L
A
V
L
A
V
L
I
E
M
G
-
S
-
F
-
N
P
S
Y
D
K
I
F
S
H
L
Q
H
V
K
Y
K
G
Q
E
A
F
V
P
G
F
N
I
E
E
L
L
P
E
-
R
T--
A
E
Y
Y
R
Y
R
G
S
L
T
T
P
P
C
N
P
T
V
L
W
T
V
F
R
N
P
V
Q
I
S
Q
E
Q
L
L
A
L
E
T
A
L
Y
C
T
--
H
MD
D
P
S
P
R
E
M
I
N
N
F
R
Q
V
Q
K
F
D
E
R
L
V
Y
T
S
F
S
Q
-------
44
HHSearch
75.43
34%
-93
- C3 -
3IAI
11
CAH9_HUMAN
A:
[4-257]
-----------------------
Q
S
H
W
R
Y
G
---------
G
D
P
P
--------
W
P
R
V
S
P
---
A
C
A
G
R
F
Q
S
P
V
D
I
R
P
Q
L
A
A
F
S
P
A
L
R
P
L
E
L
---
L
G
F
QL
P
P
L
--
P
E
L
R
L
R
N
N
G
H
S
V
Q
L
T
L
P
P
G
---
L
E
M
A
L
G
P
-
G
R
E
Y
R
A
L
Q
L
H
L
H
W
G
-
A
A
G
-
R
-
P
G
S
E
H
T
V
E
G
H
R
F
P
A
E
I
H
V
V
H
L
S
T
-
A
F
A
R
V
D
E
A
L
G
R
P
G
G
L
A
V
L
A
A
F
L
E
E
G
-
P
E
E
-
N
S
A
Y
E
Q
L
L
S
R
L
E
E
I
A
E
E
G
S
E
T
Q
V
P
G
L
D
I
S
A
L
L
P
S
-
D
F--
S
R
Y
F
Q
Y
E
G
S
L
T
T
P
P
C
A
Q
G
V
I
W
T
V
F
N
Q
T
V
M
L
S
A
K
Q
L
H
T
L
S
D
T
L
W
G
P
--
G
--
D
---
S
R
L
Q
L
N
F
R
A
T
Q
P
L
N
G
R
V
I
E
A
S
F
P
--------
38
HHSearch
71.26
31%
-77
- C3 -
3FW3
2
CAH4_HUMAN
A:
[5-266]
--------------------------
W
C
Y
E
V
Q
A
E
S
SNC
L
V
P
V
K
--------
W
G
---
G
---
N
C
Q
K
D
R
Q
S
P
I
N
I
V
T
T
K
A
K
V
D
K
K
L
G
R
F
F
F
---
S
-
G
Y-
D
K
K
--
Q
T
W
T
V
Q
N
N
G
H
S
V
M
M
L
L
E
N
K
---
A
S
I
S
G
G
G
L
P
A
P
Y
Q
A
K
Q
L
H
L
H
W
S
-
D
L
P
-
Y
-
K
G
S
E
H
S
L
D
G
E
H
F
A
M
E
M
H
I
V
H
E
K
E
K
----------
P
E
D
E
I
A
V
L
A
F
L
V
E
A
G
T
Q
-
V
-
N
E
G
F
Q
P
L
V
E
A
L
S
N
I
P
K
P
E
M
S
T
T
M
A
E
S
S
L
L
D
L
L
P
K
-
E
EKL
R
H
Y
F
R
Y
L
G
S
L
T
T
P
T
C
D
E
K
V
V
W
T
V
F
R
E
P
I
Q
L
H
R
E
Q
I
L
A
F
S
Q
K
L
Y
Y
D
--
K
--
E
Q
T
-
V
S
M
K
D
N
V
R
P
L
Q
Q
L
G
Q
R
T
V
I
K
S
----------
48
HHSearch
69.86
32%
-100
- C3 -
4G7A
1
?
A:
[25-248]
-------------------------
E
W
S
Y
E
G
--
E
----
K
G
P
E
H
--------
W
A
Q
L
K
P
EFF
W
C
K
L
K
N
Q
S
P
I
N
I
D
K
K
-
Y
K
V
K
A
N
L
P
K
L
N
L
---
Y
-
Y
--
K
T
A
--
K
E
S
E
V
V
N
N
G
H
T
I
Q
I
N
I
K
E
D
---
N
T
L
N
Y
L
G
--
E
K
Y
Q
L
K
Q
F
H
F
H
T
---------
P
S
E
H
T
I
E
K
K
S
Y
P
L
E
I
H
F
V
H
K
T
E
------------
D
G
K
I
L
V
V
G
V
M
A
K
L
G
-
K
-
T
-
N
K
E
L
D
K
I
L
N
V
A
P
A
E
E
--
G
E
K
I
L
D
K
N
L
N
L
N
N
L
I
P
K
-
D
---
K
R
Y
M
T
Y
S
G
S
L
T
T
P
P
C
T
E
G
V
R
W
I
V
L
K
K
P
I
S
I
S
K
Q
Q
L
E
K
L
K
S
V
M
V
-------------
N
-
P
N
N
R
P
V
Q
E
I
N
S
R
W
I
I
E
G
F
---------