@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PF01048_MTNN_S: (2014-09-19 )
MKIGIIGAMEEEVTLLRDKIENRQTISLGGCEIYTGQLNGTEVALLKSGIGKVAAALGATLLLEHCKPDVIINTGSAGGLAPTLKVGDIVVSDEARYHDADVTAFGYEYGQLPGCPAGFKADDKLIAAAEACIAELNLNAVRGLIVSGDAFINGSVGLAKIRHNFPQAIAVEMEATAIAHVCHNFNVPFVVVRAISDVADQQSHLSFDEFLAVAAKQSSLMVESLVQKLAHG
Atome Classification :
(36 SA)
.........10........20.-.......30----........40........50........60........70........80-.........90........100.......110.......120.......130..-..-.-.-.140.......150.......160.......170.......180.......190.......200.-......210.......220.......230
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
K
I
G
I
IGA
M
E
E
E
V
T
L
L
R
D
K
IEN-R
Q
T
I
S
LG
G
C
----
E
I
Y
TGQLNG
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
HCKP
D
V
I
I
NTGSAGGL--
A
P
T
L
K
V
G
D
I
V
VSDEARYHDADV
T
A
FGYEYGQLPGCPAGFKAD
D
K
L
I
A
A
A
E
A
C
I
A
-
E
L
-
N
-
L
-
N
A
V
R
G
L
I
VSG
D
A
F
INGSV
G
L
A
K
I
R
HNFP
Q
A
I
A
V
E
M
E
A
T
A
I
A
H
V
C
HNFNV
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S-HL
S
F
D
E
F
L
A
V
A
A
K
Q
S
S
L
M
V
E
S
L
V
Q
K
LAHG
7
PsiBlast_PDB
96.18
100%
-141
- C2 -
1Z5P
4
MTNN_ECOLI
A:
[11-242]
M
K
I
G
I
I
G
A
M
E
E
E
V
T
L
L
R
D
K
I
E
N
-
R
Q
T
I
S
L
G
G
C
----
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
--
A
P
T
L
K
V
G
D
I
V
V
S
D
E
A
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
A
C
I
A
-
E
L
-
N
-
L
-
N
A
V
R
G
L
I
V
S
G
D
A
F
I
N
G
S
V
G
L
A
K
I
R
H
N
F
P
Q
A
I
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
-
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
S
L
M
V
E
S
L
V
Q
K
L
A
H
G
9
PsiBlast_PDB
94.56
99%
-130
- C2 -
1Z5N
2
MTNN_ECOLI
A:
[11-242]
M
K
I
G
I
I
G
A
M
E
E
Q
V
T
L
L
R
D
K
I
E
N
-
R
Q
T
I
S
L
G
G
C
----
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
--
A
P
T
L
K
V
G
D
I
V
V
S
D
E
A
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
A
C
I
A
-
E
L
-
N
-
L
-
N
A
V
R
G
L
I
V
S
G
D
A
F
I
N
G
S
V
G
L
A
K
I
R
H
N
F
P
Q
A
I
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
-
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
S
L
M
V
E
S
L
V
Q
K
L
A
H
G
23
PsiBlast_CBE
94.30
100%
-126
- C2 -
1Y6Q
2
MTNN_ECOLI
B:
[11-242]
M
K
I
G
I
I
G
A
M
E
E
E
V
T
L
L
R
D
K
I
E
N
-
R
Q
T
I
S
L
G
G
C
----
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
--
A
P
T
L
K
V
G
D
I
V
V
S
D
E
A
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
A
C
I
A
-
E
L
-
N
-
L
-
N
A
V
R
G
L
I
V
S
G
D
A
F
I
N
G
S
V
G
L
A
K
I
R
H
N
F
P
Q
A
I
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
-
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
S
L
M
V
E
S
L
V
Q
K
L
A
H
G
20
PsiBlast_CBE
94.30
100%
-127
- C2 -
3O4V
7
MTNN_ECOLI
B:
[3-234]
M
K
I
G
I
I
G
A
M
E
E
E
V
T
L
L
R
D
K
I
E
N
-
R
Q
T
I
S
L
G
G
C
----
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
--
A
P
T
L
K
V
G
D
I
V
V
S
D
E
A
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
A
C
I
A
-
E
L
-
N
-
L
-
N
A
V
R
G
L
I
V
S
G
D
A
F
I
N
G
S
V
G
L
A
K
I
R
H
N
F
P
Q
A
I
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
-
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
S
L
M
V
E
S
L
V
Q
K
L
A
H
G
27
PsiBlast_CBE
94.16
99%
-127
- C2 -
1Z5N
3
MTNN_ECOLI
B:
[11-242]
M
K
I
G
I
I
G
A
M
E
E
Q
V
T
L
L
R
D
K
I
E
N
-
R
Q
T
I
S
L
G
G
C
----
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
--
A
P
T
L
K
V
G
D
I
V
V
S
D
E
A
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
A
C
I
A
-
E
L
-
N
-
L
-
N
A
V
R
G
L
I
V
S
G
D
A
F
I
N
G
S
V
G
L
A
K
I
R
H
N
F
P
Q
A
I
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
-
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
S
L
M
V
E
S
L
V
Q
K
L
A
H
G
33
PsiBlast_CBE
94.13
95%
-127
- C2 -
4F1W
8
?
B:
[17-248]
M
K
I
G
I
I
G
A
M
E
E
E
V
T
L
L
R
D
K
I
D
N
-
R
Q
T
I
T
L
G
G
C
----
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
--
A
S
T
L
K
V
G
D
I
V
V
S
D
E
T
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
S
C
I
R
-
E
L
-
N
-
L
-
N
A
V
R
G
L
I
V
S
G
D
A
F
I
N
G
S
V
G
L
A
K
I
R
H
N
F
P
D
A
V
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
-
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
T
L
M
V
E
T
L
V
Q
K
L
A
H
G
10
PsiBlast_PDB
94.05
99%
-127
- C2 -
1Z5O
2
MTNN_ECOLI
A:
[11-242]
M
K
I
G
I
I
G
A
M
E
E
E
V
T
L
L
R
D
K
I
E
N
-
R
Q
T
I
S
L
G
G
C
----
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
--
A
P
T
L
K
V
G
D
I
V
V
S
D
E
A
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
A
C
I
A
-
E
L
-
N
-
L
-
N
A
V
R
G
L
I
V
S
G
D
A
F
I
N
G
S
V
G
L
A
K
I
R
H
N
F
P
Q
A
I
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
N
V
A
D
Q
Q
S
-
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
S
L
M
V
E
S
L
V
Q
K
L
A
H
G
4
PsiBlast_PDB
94.00
100%
-127
- C2 -
1NC1
1
MTNN_ECOLI
A:
[11-242]
M
K
I
G
I
I
G
A
M
E
E
E
V
T
L
L
R
D
K
I
E
N
-
R
Q
T
I
S
L
G
G
C
----
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
--
A
P
T
L
K
V
G
D
I
V
V
S
D
E
A
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
A
C
I
A
-
E
L
-
N
-
L
-
N
A
V
R
G
L
I
V
S
G
D
A
F
I
N
G
S
V
G
L
A
K
I
R
H
N
F
P
Q
A
I
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
-
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
S
L
M
V
E
S
L
V
Q
K
L
A
H
G
47
HHSearch
93.85
96%
-137
- C2 -
4F1W
11
?
A:
[17-247]
M
K
I
G
I
I
G
A
M
E
E
E
V
T
L
L
R
D
K
I
D
N
-
R
Q
T
I
T
L
G
G
C
----
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
--
A
S
T
L
K
V
G
D
I
V
V
S
D
E
T
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
S
C
I
R
-
E
L
-
N
-
L
-
N
A
V
R
G
L
I
V
S
G
D
A
F
I
N
G
S
V
G
L
A
K
I
R
H
N
F
P
D
A
V
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
-
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
T
L
M
V
E
T
L
V
Q
K
L
A
H
-
5
PsiBlast_PDB
93.73
100%
-128
- C2 -
1Y6Q
2
MTNN_ECOLI
A:
[11-242]
M
K
I
G
I
I
G
A
M
E
E
E
V
T
L
L
R
D
K
I
E
N
-
R
Q
T
I
S
L
G
G
C
----
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
--
A
P
T
L
K
V
G
D
I
V
V
S
D
E
A
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
A
C
I
A
-
E
L
-
N
-
L
-
N
A
V
R
G
L
I
V
S
G
D
A
F
I
N
G
S
V
G
L
A
K
I
R
H
N
F
P
Q
A
I
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
-
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
S
L
M
V
E
S
L
V
Q
K
L
A
H
G
3
PsiBlast_PDB
93.71
100%
-128
- C2 -
1NC3
1
MTNN_ECOLI
A:
[11-242]
M
K
I
G
I
I
G
A
M
E
E
E
V
T
L
L
R
D
K
I
E
N
-
R
Q
T
I
S
L
G
G
C
----
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
--
A
P
T
L
K
V
G
D
I
V
V
S
D
E
A
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
A
C
I
A
-
E
L
-
N
-
L
-
N
A
V
R
G
L
I
V
S
G
D
A
F
I
N
G
S
V
G
L
A
K
I
R
H
N
F
P
Q
A
I
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
-
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
S
L
M
V
E
S
L
V
Q
K
L
A
H
G
22
PsiBlast_CBE
93.40
100%
-127
- C2 -
1Y6R
2
MTNN_ECOLI
B:
[11-242]
M
K
I
G
I
I
G
A
M
E
E
E
V
T
L
L
R
D
K
I
E
N
-
R
Q
T
I
S
L
G
G
C
----
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
--
A
P
T
L
K
V
G
D
I
V
V
S
D
E
A
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
A
C
I
A
-
E
L
-
N
-
L
-
N
A
V
R
G
L
I
V
S
G
D
A
F
I
N
G
S
V
G
L
A
K
I
R
H
N
F
P
Q
A
I
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
-
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
S
L
M
V
E
S
L
V
Q
K
L
A
H
G
6
PsiBlast_PDB
93.37
100%
-125
- C2 -
1Y6R
2
MTNN_ECOLI
A:
[11-242]
M
K
I
G
I
I
G
A
M
E
E
E
V
T
L
L
R
D
K
I
E
N
-
R
Q
T
I
S
L
G
G
C
----
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
--
A
P
T
L
K
V
G
D
I
V
V
S
D
E
A
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
A
C
I
A
-
E
L
-
N
-
L
-
N
A
V
R
G
L
I
V
S
G
D
A
F
I
N
G
S
V
G
L
A
K
I
R
H
N
F
P
Q
A
I
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
-
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
S
L
M
V
E
S
L
V
Q
K
L
A
H
G
21
PsiBlast_CBE
93.28
100%
-128
- C2 -
3DF9
2
MTNN_ECO57
B:
[11-242]
M
K
I
G
I
I
G
A
M
E
E
E
V
T
L
L
R
D
K
I
E
N
-
R
Q
T
I
S
L
G
G
C
----
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
--
A
P
T
L
K
V
G
D
I
V
V
S
D
E
A
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
A
C
I
A
-
E
L
-
N
-
L
-
N
A
V
R
G
L
I
V
S
G
D
A
F
I
N
G
S
V
G
L
A
K
I
R
H
N
F
P
Q
A
I
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
-
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
S
L
M
V
E
S
L
V
Q
K
L
A
H
G
2
PsiBlast_PDB
93.25
100%
-140
- C2 -
1JYS
1
MTNN_ECOLI
A:
[11-240]
M
K
I
G
I
I
G
A
M
E
E
E
V
T
L
L
R
D
K
I
E
N
-
R
Q
T
I
S
L
G
G
C
----
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
--
A
P
T
L
K
V
G
D
I
V
V
S
D
E
A
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
A
C
I
A
-
E
L
-
N
-
L
-
N
A
V
R
G
L
I
V
S
G
D
A
F
I
N
G
S
V
G
L
A
K
I
R
H
N
F
P
Q
A
I
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
-----
S
F
D
E
F
L
A
V
A
A
K
Q
S
S
L
M
V
E
S
L
V
Q
K
L
A
--
30
PsiBlast_CBE
93.22
95%
-129
- C2 -
4F3C
4
?
B:
[17-246]
M
K
I
G
I
I
G
A
M
E
E
E
V
T
L
L
R
D
K
I
D
N
-
R
Q
T
I
T
L
G
G
C
----
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
--
A
S
T
L
K
V
G
D
I
V
V
S
D
E
T
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
S
C
I
R
-
E
L
-
N
-
L
-
N
A
V
R
G
L
I
V
S
G
D
A
F
I
N
G
S
V
G
L
A
K
I
R
H
N
F
P
D
A
V
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
-
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
T
L
M
V
E
T
L
V
Q
K
L
A
--
26
PsiBlast_CBE
93.12
100%
-139
- C2 -
1JYS
1
MTNN_ECOLI
B:
[11-240]
M
K
I
G
I
I
G
A
M
E
E
E
V
T
L
L
R
D
K
I
E
N
-
R
Q
T
I
S
L
G
G
C
----
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
--
A
P
T
L
K
V
G
D
I
V
V
S
D
E
A
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
A
C
I
A
-
E
L
-
N
-
L
-
N
A
V
R
G
L
I
V
S
G
D
A
F
I
N
G
S
V
G
L
A
K
I
R
H
N
F
P
Q
A
I
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
-----
S
F
D
E
F
L
A
V
A
A
K
Q
S
S
L
M
V
E
S
L
V
Q
K
L
A
--
32
PsiBlast_CBE
93.04
95%
-127
- C2 -
4F2P
4
?
B:
[17-248]
M
K
I
G
I
I
G
A
M
E
E
E
V
T
L
L
R
D
K
I
D
N
-
R
Q
T
I
T
L
G
G
C
----
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
--
A
S
T
L
K
V
G
D
I
V
V
S
D
E
T
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
S
C
I
R
-
E
L
-
N
-
L
-
N
A
V
R
G
L
I
V
S
G
D
A
F
I
N
G
S
V
G
L
A
K
I
R
H
N
F
P
D
A
V
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
-
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
T
L
M
V
E
T
L
V
Q
K
L
A
H
G
25
PsiBlast_CBE
93.04
100%
-124
- C2 -
1NC1
1
MTNN_ECOLI
B:
[11-242]
M
K
I
G
I
I
G
A
M
E
E
E
V
T
L
L
R
D
K
I
E
N
-
R
Q
T
I
S
L
G
G
C
----
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
--
A
P
T
L
K
V
G
D
I
V
V
S
D
E
A
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
A
C
I
A
-
E
L
-
N
-
L
-
N
A
V
R
G
L
I
V
S
G
D
A
F
I
N
G
S
V
G
L
A
K
I
R
H
N
F
P
Q
A
I
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
-
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
S
L
M
V
E
S
L
V
Q
K
L
A
H
G
28
PsiBlast_CBE
92.90
99%
-127
- C2 -
1Z5O
2
MTNN_ECOLI
B:
[11-242]
M
K
I
G
I
I
G
A
M
E
E
E
V
T
L
L
R
D
K
I
E
N
-
R
Q
T
I
S
L
G
G
C
----
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
--
A
P
T
L
K
V
G
D
I
V
V
S
D
E
A
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
A
C
I
A
-
E
L
-
N
-
L
-
N
A
V
R
G
L
I
V
S
G
D
A
F
I
N
G
S
V
G
L
A
K
I
R
H
N
F
P
Q
A
I
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
N
V
A
D
Q
Q
S
-
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
S
L
M
V
E
S
L
V
Q
K
L
A
H
G
8
PsiBlast_PDB
92.82
100%
-127
- C2 -
3DF9
2
MTNN_ECO57
A:
[11-242]
M
K
I
G
I
I
G
A
M
E
E
E
V
T
L
L
R
D
K
I
E
N
-
R
Q
T
I
S
L
G
G
C
----
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
--
A
P
T
L
K
V
G
D
I
V
V
S
D
E
A
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
A
C
I
A
-
E
L
-
N
-
L
-
N
A
V
R
G
L
I
V
S
G
D
A
F
I
N
G
S
V
G
L
A
K
I
R
H
N
F
P
Q
A
I
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
-
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
S
L
M
V
E
S
L
V
Q
K
L
A
H
G
24
PsiBlast_CBE
92.67
100%
-125
- C2 -
1NC3
1
MTNN_ECOLI
B:
[11-240]
M
K
I
G
I
I
G
A
M
E
E
E
V
T
L
L
R
D
K
I
E
N
-
R
Q
T
I
S
L
G
G
C
----
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
--
A
P
T
L
K
V
G
D
I
V
V
S
D
E
A
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
A
C
I
A
-
E
L
-
N
-
L
-
N
A
V
R
G
L
I
V
S
G
D
A
F
I
N
G
S
V
G
L
A
K
I
R
H
N
F
P
Q
A
I
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
-
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
S
L
M
V
E
S
L
V
Q
K
L
A
--
12
PsiBlast_PDB
92.65
95%
-127
- C2 -
4F2P
5
?
A:
[17-247]
M
K
I
G
I
I
G
A
M
E
E
E
V
T
L
L
R
D
K
I
D
N
-
R
Q
T
I
T
L
G
G
C
----
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
--
A
S
T
L
K
V
G
D
I
V
V
S
D
E
T
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
S
C
I
R
-
E
L
-
N
-
L
-
N
A
V
R
G
L
I
V
S
G
D
A
F
I
N
G
S
V
G
L
A
K
I
R
H
N
F
P
D
A
V
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
-
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
T
L
M
V
E
T
L
V
Q
K
L
A
H
-
1
PsiBlast_PDB
92.45
100%
-125
- C2 -
3O4V
5
MTNN_ECOLI
A:
[3-234]
M
K
I
G
I
I
G
A
M
E
E
E
V
T
L
L
R
D
K
I
E
N
-
R
Q
T
I
S
L
G
G
C
----
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
--
A
P
T
L
K
V
G
D
I
V
V
S
D
E
A
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
A
C
I
A
-
E
L
-
N
-
L
-
N
A
V
R
G
L
I
V
S
G
D
A
F
I
N
G
S
V
G
L
A
K
I
R
H
N
F
P
Q
A
I
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
-
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
S
L
M
V
E
S
L
V
Q
K
L
A
H
G
13
PsiBlast_PDB
92.43
95%
-126
- C2 -
4F2W
4
?
A:
[17-247]
M
K
I
G
I
I
G
A
M
E
E
E
V
T
L
L
R
D
K
I
D
N
-
R
Q
T
I
T
L
G
G
C
----
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
--
A
S
T
L
K
V
G
D
I
V
V
S
D
E
T
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
S
C
I
R
-
E
L
-
N
-
L
-
N
A
V
R
G
L
I
V
S
G
D
A
F
I
N
G
S
V
G
L
A
K
I
R
H
N
F
P
D
A
V
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
-
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
T
L
M
V
E
T
L
V
Q
K
L
A
H
-
14
PsiBlast_PDB
92.20
95%
-127
- C2 -
4F3C
4
?
A:
[17-246]
M
K
I
G
I
I
G
A
M
E
E
E
V
T
L
L
R
D
K
I
D
N
-
R
Q
T
I
T
L
G
G
C
----
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
--
A
S
T
L
K
V
G
D
I
V
V
S
D
E
T
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
S
C
I
R
-
E
L
-
N
-
L
-
N
A
V
R
G
L
I
V
S
G
D
A
F
I
N
G
S
V
G
L
A
K
I
R
H
N
F
P
D
A
V
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
-
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
T
L
M
V
E
T
L
V
Q
K
L
A
--
31
PsiBlast_CBE
91.99
95%
-127
- C2 -
4F2W
6
?
B:
[17-246]
M
K
I
G
I
I
G
A
M
E
E
E
V
T
L
L
R
D
K
I
D
N
-
R
Q
T
I
T
L
G
G
C
----
E
I
Y
T
G
Q
L
N
G
T
E
V
A
L
L
K
S
G
I
G
K
V
A
A
A
L
G
A
T
L
L
L
E
H
C
K
P
D
V
I
I
N
T
G
S
A
G
G
L
--
A
S
T
L
K
V
G
D
I
V
V
S
D
E
T
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
G
C
P
A
G
F
K
A
D
D
K
L
I
A
A
A
E
S
C
I
R
-
E
L
-
N
-
L
-
N
A
V
R
G
L
I
V
S
G
D
A
F
I
N
G
S
V
G
L
A
K
I
R
H
N
F
P
D
A
V
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
N
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
-
H
L
S
F
D
E
F
L
A
V
A
A
K
Q
S
T
L
M
V
E
T
L
V
Q
K
L
A
--
16
PsiBlast_PDB
91.71
90%
-130
- C2 -
4G89
2
MTNN_KLEP7
A:
[6-237]
M
K
I
G
I
I
G
A
M
E
E
E
V
T
L
L
R
D
K
I
E
N
-
R
Q
T
I
T
I
G
G
S
----
E
I
Y
T
G
Q
L
H
G
V
D
V
A
L
L
K
S
G
I
G
K
V
A
A
A
M
G
A
T
L
L
L
E
R
C
Q
P
D
V
I
I
N
T
G
S
A
G
G
L
--
A
S
T
L
K
V
G
D
I
V
V
S
D
E
A
R
Y
H
D
A
D
V
T
A
F
G
Y
E
Y
G
Q
L
P
G
C
P
A
G
F
K
A
D
E
K
L
V
A
A
A
E
S
C
I
K
-
A
L
-
D
-
L
-
N
A
V
R
G
L
I
V
S
G
D
A
F
I
N
G
S
V
G
L
A
K
I
R
H
N
F
P
Q
A
I
A
V
E
M
E
A
T
A
I
A
H
V
C
H
N
F
K
V
P
F
V
V
V
R
A
I
S
D
V
A
D
Q
Q
S
-
H
L
S
F
E
E
F
L
A
V
A
A
R
Q
S
T
L
M
V
E
N
L
V
Q
N
L
A
R
G
46
HHSearch
78.01
60%
-121
- C2 -
3DP9
2
MTNN_VIBCH
A:
[2-230]
-
K
I
G
I
I
G
A
M
Q
Q
E
V
A
I
L
K
D
L
I
E
D
-
V
Q
E
V
N
Q
A
G
C
----
T
F
Y
S
G
Q
I
Q
G
V
D
V
V
L
L
Q
S
G
I
G
K
V
S
A
A
L
G
T
A
L
L
I
S
Q
Y
A
P
D
V
V
I
N
T
G
S
A
G
G
F
--
D
A
S
L
N
V
G
D
V
V
I
S
S
E
V
R
H
H
D
A
D
V
T
A
F
G
Y
E
I
G
Q
M
A
G
Q
P
A
A
F
K
A
D
E
K
L
M
T
V
A
E
Q
A
L
A
-
Q
L
-
P
N
T
-
H
A
V
R
G
L
I
C
T
G
D
A
F
V
C
T
A
E
R
Q
Q
F
I
R
Q
H
F
P
S
V
V
A
V
E
M
E
A
S
A
I
A
Q
T
C
H
Q
F
K
V
P
F
V
V
V
R
A
I
S
D
V
A
D
K
E
S
-
P
L
S
F
E
E
F
L
P
L
A
A
K
S
S
S
A
M
V
L
K
M
V
E
L
L
---
44
HHSearch
75.58
55%
-121
- C2 -
3BL6
1
MTNN_STAAM
A:
[2-230]
M
M
I
G
I
I
G
A
M
E
E
E
V
T
I
L
K
N
K
L
T
Q
-
L
S
E
I
S
V
A
H
V
----
K
F
Y
T
G
I
L
K
D
R
E
V
V
I
T
Q
S
G
I
G
K
V
N
A
A
I
S
T
T
L
L
I
N
K
F
K
P
D
V
I
I
N
T
G
S
A
G
A
L
--
D
E
S
L
N
V
G
D
V
L
I
S
D
D
V
K
Y
H
D
A
D
A
T
A
F
G
Y
E
Y
G
Q
I
P
Q
M
P
V
A
F
Q
S
S
K
P
L
I
E
K
V
S
Q
V
V
Q
-
Q
Q
-
Q
-
L
-
T
A
K
V
G
L
I
V
S
G
D
S
F
I
G
S
V
E
Q
R
Q
K
I
K
K
A
F
P
N
A
M
A
V
E
M
E
A
T
A
I
A
Q
T
C
Y
Q
F
N
V
P
F
V
V
V
R
A
V
S
D
L
A
N
G
E
A
-
E
M
S
F
E
A
F
L
E
K
A
A
V
S
S
S
Q
T
V
E
A
L
V
S
Q
L
---
45
HHSearch
74.29
48%
-119
* C2 *
3EEI
2
?
A:
[4-233]
K
T
V
A
V
I
G
A
M
E
Q
E
I
E
L
L
R
E
M
M
E
N
-
V
K
A
V
S
F
G
R
F
----
S
A
Y
E
G
E
L
A
G
K
R
M
V
L
A
L
S
G
I
G
K
V
N
A
A
V
A
T
A
W
I
I
R
E
F
A
A
D
C
V
I
N
T
G
S
A
G
G
L
--
G
K
G
L
K
V
G
D
V
V
I
G
T
E
T
A
H
H
D
V
D
V
T
A
F
G
Y
A
W
G
Q
V
P
Q
L
P
A
R
F
A
S
D
G
I
L
I
E
A
A
K
R
A
A
R
-
T
F
-
E
-
G
A
A
V
E
Q
G
L
I
V
S
G
D
R
F
V
H
S
S
E
G
V
A
E
I
R
K
H
F
P
E
V
K
A
V
E
M
E
A
A
A
I
A
Q
T
C
H
Q
L
E
T
P
F
V
I
I
R
A
V
S
D
S
A
D
E
K
A
-
D
I
S
F
D
E
F
L
K
T
A
A
A
N
S
A
K
M
V
A
E
I
V
K
S
L
---
51
HHSearch
72.53
41%
-121
- C2 -
4KN5
3
?
A:
[23-253]
M
R
Y
G
V
I
N
A
M
A
E
E
K
A
A
L
V
D
A
M
I
D
-
E
K
K
T
T
I
A
G
K
----
L
F
H
H
G
K
I
G
H
V
D
V
V
V
V
E
S
G
I
G
K
V
A
S
A
L
T
T
T
L
L
I
T
N
F
G
V
D
A
V
I
N
S
G
S
A
G
A
L
--
G
T
D
L
R
I
G
D
I
V
I
A
D
Y
L
A
Y
A
D
A
D
A
R
A
F
G
Y
A
Y
G
Q
V
P
Q
Q
P
A
R
F
K
A
D
T
D
L
S
N
D
L
S
E
S
Y
E
-
K
V
T
D
-
A
-
R
L
V
R
G
L
V
V
T
S
D
S
F
I
A
S
N
E
Q
K
Q
T
I
L
T
H
F
P
E
A
Q
S
A
E
M
E
G
A
S
I
A
Q
V
A
N
Y
F
D
V
P
F
A
V
V
R
A
I
S
D
N
A
N
G
E
A
-
G
M
T
F
D
D
F
I
V
E
A
G
Q
Q
S
A
Q
V
L
I
N
F
F
E
A
Q
A
--
54
HHSearch
71.70
39%
-116
- C2 -
4L0M
1
?
A:
[23-259]
-
M
I
L
I
I
S
A
M
Q
E
E
S
E
E
I
N
K
I
L
D
N
-
K
E
E
I
V
L
N
D
Y
LEN
K
K
I
Y
K
G
K
I
L
G
K
D
V
I
S
L
T
T
G
I
G
K
V
N
A
A
T
W
S
S
Q
I
I
S
K
Y
K
I
T
H
I
I
N
S
G
S
S
G
G
I
KE
N
S
N
L
K
I
L
D
I
I
V
S
S
E
T
A
Y
Y
D
F
D
L
T
K
F
G
H
K
I
G
Q
V
P
N
L
P
Q
K
F
K
A
D
E
E
L
L
K
K
V
A
N
I
V
D
N
K
L
L
N
-
I
-
D
I
H
I
G
L
I
L
T
G
D
Q
F
V
D
N
E
K
N
L
E
T
I
K
K
N
F
K
D
A
L
A
V
D
M
E
G
A
A
I
A
Q
V
A
H
I
F
K
I
P
F
I
I
I
R
S
I
S
D
L
P
N
N
K
D
N
H
I
D
F
N
K
F
L
K
T
S
S
I
N
S
S
K
M
T
K
E
L
I
R
L
I
---
53
HHSearch
68.13
37%
-115
- C2 -
4JOS
3
?
A:
[24-250]
K
K
I
A
I
L
G
A
M
E
I
E
I
Q
P
I
L
Q
K
L
E
K
-
Y
E
T
V
E
Y
A
N
N
----
K
Y
Y
V
A
N
Y
N
G
I
E
L
V
V
A
Y
S
K
I
G
K
V
F
S
S
L
T
A
T
I
M
I
E
H
F
G
V
D
A
L
L
F
T
G
V
A
G
G
L
--
Q
-
D
L
Q
V
G
D
M
I
A
A
T
A
T
V
Q
H
D
V
D
I
T
A
F
G
Y
P
Y
G
K
I
P
I
S
E
V
E
I
A
T
S
A
R
I
L
E
Q
A
K
V
I
A
K
-
E
L
-
N
-
L
-
N
L
H
T
G
V
I
A
T
G
D
Q
F
V
H
S
A
E
R
K
D
F
V
V
K
E
F
-
D
A
K
A
I
E
M
E
G
A
S
V
N
L
I
C
N
E
M
N
I
P
S
F
I
L
R
S
I
S
D
T
A
D
G
D
A
-
P
D
N
F
D
E
F
A
K
M
A
A
N
R
S
A
D
F
V
M
K
L
V
D
R
I
---
52
HHSearch
67.62
36%
-118
- C2 -
4JWT
5
?
A:
[23-251]
M
K
I
A
I
M
G
A
M
P
E
E
I
S
P
I
L
E
K
I
G
S
-
Y
K
S
T
S
Y
A
G
N
----
K
Y
Y
E
A
T
Y
Q
G
V
E
L
V
I
A
Y
S
K
I
G
K
V
F
S
A
L
S
A
A
T
M
I
E
H
F
G
A
T
K
L
L
F
S
G
V
A
G
A
I
--
S
T
N
L
K
V
G
D
L
I
V
A
T
K
L
S
Q
H
D
L
D
I
T
A
F
G
H
P
Y
G
Y
V
P
E
G
S
V
F
V
E
A
D
K
D
M
I
E
L
S
K
K
V
A
L
-
E
M
-
G
-
K
-
S
V
Q
E
G
I
I
A
T
G
D
Q
F
V
A
N
E
E
R
K
N
W
I
G
T
T
F
-
G
A
D
A
L
E
M
E
G
G
S
V
G
V
V
C
N
A
L
N
I
P
F
F
I
L
R
S
I
S
D
A
A
D
M
D
A
-
S
F
S
F
D
E
F
L
E
S
S
A
K
E
S
A
E
F
I
M
K
M
V
D
E
L
V
--
50
HHSearch
64.21
35%
-112
- C2 -
3NM6
6
MQMTN_HELPJ
B:
[2-230]
Q
K
I
G
I
L
G
A
M
R
E
E
I
T
P
I
L
E
L
F
G
V
D
F
E
E
I
P
L
G
G
N
----
V
F
H
K
G
V
Y
H
N
K
E
I
I
V
A
Y
S
K
I
G
K
V
H
S
T
L
T
T
T
S
M
I
L
A
F
G
V
Q
K
V
L
F
S
G
V
A
G
S
L
--
V
K
D
L
K
I
N
D
L
L
V
A
T
Q
L
V
Q
H
D
V
D
L
S
A
F
D
H
P
L
G
F
I
P
E
S
A
I
F
I
E
T
S
G
S
L
N
A
L
A
K
K
I
A
N
-
E
Q
-
H
-
I
-
A
L
K
E
G
V
I
A
S
G
D
Q
F
V
H
S
K
E
R
K
E
F
L
V
S
E
F
-
K
A
S
A
V
E
M
E
G
A
S
V
A
F
V
C
Q
K
F
G
V
P
C
C
V
L
R
S
I
S
D
N
A
D
E
K
A
-
G
M
S
F
D
E
F
L
E
K
S
A
H
T
S
A
K
F
L
K
S
M
V
D
E
L
---