@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : ACKR2_HUMAN: (2016-01-08 )
MAATASPQPLATEDADSENSSFYYYDYLDEVAFMLCRKDAVVSFGKVFLPVFYSLIFVLGLSGNLLLLMVLLRYVPRRRMVEIYLLNLAISNLLFLVTLPFWGISVAWHWVFGSFLCKMVSTLYTINFYSGIFFISCMSLDKYLEIVHAQPYHRLRTRAKSLLLATIVWAVSLAVSIPDMVFVQTHENPKGVWNCHADFGGHGTIWKLFLRFQQNLLGFLLPLLAMIFFYSRIGCVLVRLRPAGQGRALKIAAALVVAFFVLWFPYNLTLFLHTLLDLQVFGNCEVSQHLDYALQVTESIAFLHCCFSPILYAFSSHRFRQYLKAFLAAVLGWHLAPGTAQASLSSCSESSILTAQEEMTGMNDLGERQSENYPNKEDVGNKSA
Atome Classification :
(20 SA)
........---.10........20........30........40........50........60........70........80---........90....-..---.--.100.-..-..--..--110.......120.......130.......140.......150...---....160.--......170....-...180-......--.190-.-......200.....--...210......-.220.......230---..-------------.....------------------------------------------------.240--------------------------------------------------------------------------------------------------------------------------------------------------------------------...-----------.--------------...250.......260......--.270.......-280.-.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380..-
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAATASPQ---PLATEDADSENS
S
F
Y
Y
Y
D
Y
L
D
E
V
A
F
M
L
C
R
K
D
A
V
V
S
F
G
K
V
F
L
P
V
F
Y
S
L
I
F
V
LGLS
G
N
L
L
L
L
M
V
L
L
R
YVPR
R
R
M
V
---
E
I
Y
L
L
N
L
A
I
S
N
L
L
F
-
L
V
---T--LPFW
G
-
I
S
-
V
A
--
W
H
--
W
V
F
G
S
F
L
C
K
M
V
S
T
L
Y
T
I
N
FYS
G
I
F
F
I
S
C
M
S
L
D
K
Y
L
E
I
V
HAQ
P
Y
H
R
L
---
R
T
R
A
K
S
L
L
--
L
A
T
I
V
W
A
V
S
L
A
VS-IP
D
M
V
F
-
V
QTHEN--PK
G
V
-
W
-
N
CHADFG-G
H
G
T
I
W
--
K
L
F
L
R
F
Q
Q
N
L
L
G
-
F
L
L
P
L
L
A
M
I
F
F
Y
S----RI-------------
G
C
V
L
V
------------------------------------------------
R
L
RP--------------------------------------------------------------------------------------------------------------------------------------------------------------------AGQ-----------G--------------
R
A
L
K
I
A
A
A
L
V
V
A
F
F
V
L
W
FP
Y
N
L
--
T
L
F
L
H
T
L
L
D
L
Q
-
V
F-G-NC
E
V
S
Q
H
L
D
Y
A
L
Q
V
T
E
S
I
A
F
L
H
C
C
F
S
P
I
L
Y
A
F
S
S
H
R
F
R
Q
Y
L
K
A
F
L
A
A
V
L
GWHLAPGT
A
Q
A
S
L
S
SCSESSI
L
T
A
Q
E
E
MTG
M
N
D
L
G
E
R
QSENYP
N
K
E
DVGNKSA-
21
PsiBlast_CBE
93.00
32%
-172
- C2 -
4MBS
7
CCR5_HUMAN (first)
B:
[22-364]
--------------------------------------
C
Q
K
I
N
V
K
Q
I
A
A
R
L
L
P
P
L
Y
S
L
V
F
I
F
G
F
V
G
N
M
L
V
I
L
I
L
I
N
Y
K
R
L
K
S
M
T
---
D
I
Y
L
L
N
L
A
I
S
D
L
F
F
-
L
L
---
T
--
V
P
F
W
A
-
H
Y
-
A
A
--
A
Q
--
W
D
F
G
N
T
M
C
Q
L
L
T
G
L
Y
F
I
G
F
F
S
G
I
F
F
I
I
L
L
T
I
D
R
Y
L
A
V
V
H
A
V
F
A
L
K
A
---
R
T
V
T
F
G
V
V
--
T
S
V
I
T
W
V
V
A
V
F
A
S
-
L
P
N
I
I
F
-
T
R
S
Q
K
----
E
G
L
H
Y
-
T
C
S
S
H
F
P
Y
S
Q
Y
Q
F
W
--
K
N
F
Q
T
L
K
I
V
I
L
G
-
L
V
L
P
L
L
V
M
V
I
C
Y
S
----
G
I
-------------
L
K
T
L
L
------------------------------------------------
R
M
K
K
YTCTVCGYIYNPEDGDPDNGVNPGTDFKDIPDDWVCPL------------------------------------------------------------------------------------------------------------------------------
C
G
V
-----------
G
KDQFEEVEEEKKRH
R
D
V
R
L
I
F
T
I
M
I
V
Y
F
L
F
W
A
P
Y
N
I
--
V
L
L
L
N
T
F
Q
E
F
F
-
G
L
-
N
-
N
C
S
S
S
N
R
L
D
Q
A
M
Q
V
T
E
T
L
G
M
T
H
C
C
I
N
P
I
I
Y
A
F
V
G
E
E
F
R
N
Y
L
L
V
F
F
Q
---------------------------------------------------------
1
PsiBlast_PDB
91.61
32%
-171
- C2 -
4MBS
8
CCR5_HUMAN (first)
A:
[22-364]
--------------------------------------
C
Q
K
I
N
V
K
Q
I
A
A
R
L
L
P
P
L
Y
S
L
V
F
I
F
G
F
V
G
N
M
L
V
I
L
I
L
I
N
Y
K
R
L
K
S
M
T
---
D
I
Y
L
L
N
L
A
I
S
D
L
F
F
-
L
L
---
T
--
V
P
F
W
A
-
H
Y
-
A
A
--
A
Q
--
W
D
F
G
N
T
M
C
Q
L
L
T
G
L
Y
F
I
G
F
F
S
G
I
F
F
I
I
L
L
T
I
D
R
Y
L
A
V
V
H
A
V
F
A
L
K
A
---
R
T
V
T
F
G
V
V
--
T
S
V
I
T
W
V
V
A
V
F
A
S
-
L
P
N
I
I
F
-
T
R
S
Q
K
----
E
G
L
H
Y
-
T
C
S
S
H
F
P
Y
S
Q
Y
Q
F
W
--
K
N
F
Q
T
L
K
I
V
I
L
G
-
L
V
L
P
L
L
V
M
V
I
C
Y
S
----
G
I
-------------
L
K
T
L
L
------------------------------------------------
R
M
K
K
Y
T
C
TVCG
Y
I
Y
N
PEDGDPDNGVNPGTDFKDIPDDWVCPL------------------------------------------------------------------------------------------------------------------------------
C
G
V
-----------
G
KDQ
F
E
E
V
E
E
EK
K
R
H
R
D
V
R
L
I
F
T
I
M
I
V
Y
F
L
F
W
A
P
Y
N
I
--
V
L
L
L
N
T
F
Q
E
F
F
-
G
L
-
N
-
N
C
S
S
S
N
R
L
D
Q
A
M
Q
V
T
E
T
L
G
M
T
H
C
C
I
N
P
I
I
Y
A
F
V
G
E
E
F
R
N
Y
L
L
V
F
F
Q
---------------------------------------------------------
26
HHSearch
91.05
33%
-160
- C2 -
3ODU
6
CXCR4_HUMAN (first)
A:
[37-498]
-------------------------------------
P
C
F
R
E
E
N
A
N
F
N
K
I
F
L
P
T
I
Y
S
I
I
F
L
T
G
I
V
G
N
G
L
V
I
L
V
M
G
Y
Q
K
K
L
R
S
M
T
---
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
-
V
I
---
T
--
L
P
F
W
A
-
V
D
-
A
V
--
A
N
--
W
Y
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
N
S
Q
R
P
---
R
K
L
L
A
E
K
V
--
V
Y
V
G
V
W
I
P
A
L
L
L
T
-
I
P
D
F
I
F
-
A
N
V
S
E
---
A
D
D
R
-
Y
-
I
C
D
R
F
Y
P
-
N
D
--
L
W
--
V
V
V
F
Q
F
Q
H
I
M
V
G
-
L
I
L
P
G
I
V
I
L
S
C
Y
C
----
I
I
-------------
I
S
K
L
S
------------------------------------------------
H
S
G
S
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYGSK
G
H
Q
K
-----------
R
--------------
K
A
L
K
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
Y
Y
I
--
G
I
S
I
D
S
F
I
L
L
E
-
I
I
K
Q
-
G
C
E
F
E
N
T
V
H
K
W
I
S
I
T
E
A
L
A
F
F
H
C
C
L
N
P
I
L
Y
A
F
L
G
A
K
F
K
T
S
A
Q
H
A
L
T
S
G
R
P
L
E
V
L
F
Q
-----------------------------------------------
28
HHSearch
80.47
21%
-149
- C2 -
2RH1
16
ADRB2_HUMAN (first)
A:
[39-477]
-----------------------------------------------
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
---
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
-
G
L
---
A
V-
V
P
F
G
A
-
A
H
-
I
L
M
-
K
M
--
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
--
I
I
L
M
V
W
I
V
S
G
L
T
S
-
F
L
P
I
Q
M
H
W
Y
R
A
T
H
---
Q
E
A
-
I
-
N
C
Y
A
E
E
T
-
C
C
D
F
F
T
--
N
Q
A
Y
A
I
A
S
S
I
V
S
-
F
Y
V
P
L
V
I
M
V
F
V
Y
S
----
R
V
-------------
F
Q
E
A
K
------------------------------------------------
R
Q
L
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFC--
L
K
E
-----------
H
--------------
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
--
V
N
I
V
H
V
I
Q
D
N
------------
L
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
--------------------------------------------------------
46
Fugue
80.28
23%
-163
- C2 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
-----------------------------------
S
F
K
C
A
L
T
K
T
-
G
F
Q
F
Y
Y
L
P
A
V
Y
I
L
V
F
I
I
G
F
L
G
N
S
V
A
I
W
M
F
V
F
H
M
K
P
W
S
G
I
---
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
-
V
L
---
T
--
L
P
A
L
I
-
F
Y
-
Y
F
--
N
K
TD
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
K
S
L
G
R
L
---
K
-
K
K
N
A
I
C
--
I
S
V
L
V
W
L
I
V
V
V
A
I
-
S
P
I
L
F
Y
-
S
G
T
G
V
R
--
K
N
K
T
-
I
-
T
C
Y
-
D
T
T
-
S
D
E
Y
L
R
--
S
Y
F
I
Y
S
M
C
T
T
V
A
M
F
C
V
P
L
V
L
I
L
G
C
Y
G
----
L
I
-------------
V
R
A
L
I
Y
K
M
K
K
Y
T
C
TVCG
Y
I
Y
N
PEDGDPDNGVNPGTDFKDIVCPLCGVGKDQ
F
E
E
V
E
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
R
-----------
R
--------------
K
S
I
Y
L
V
I
I
V
L
T
V
F
A
V
S
Y
I
P
F
H
V
M
K
T
M
N
L
R
A
R
L
D
F
Q
-
T
P
-
A
-
M
C
A
F
N
D
R
V
Y
A
T
Y
Q
V
T
R
G
L
A
S
L
N
S
C
V
N
P
I
L
Y
F
L
A
G
D
T
F
R
R
R
---------------------------------------------------------------
38
HHSearch
79.86
22%
-160
- C2 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
---------------------------------------------------
Y
A
L
S
Y
C
A
L
I
L
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
T
T
---
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
-
A
T
L--
V
--
M
P
W
V
V
-
Y
L
-
E
V
T
G
G
V
--
W
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
--
M
I
T
A
V
W
V
L
A
F
A
V
S
-
C
P
L
L
F
G
-
F
N
T
T
G
-----
D
P
-
T
-
V
C
S
I
S
N
P
-----------
D
F
V
I
Y
S
S
V
V
S
-
F
Y
L
P
F
G
V
T
V
L
V
Y
A
----
R
I
-------------
Y
V
V
L
K
------------------------------------------------
Q
R
R
R
K
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWDAYGVP
L
R
E
-----------
K
--------------
K
A
T
Q
M
V
A
I
V
L
G
A
F
I
V
C
W
L
P
F
F
L
--
T
H
V
L
N
T
H
C
Q
T
-----------
C
H
V
S
P
E
L
Y
S
A
T
T
W
L
G
Y
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
S
C
--------------------------------------------------------
3
PsiBlast_PDB
79.45
31%
-177
- C2 -
4XT1
13
US28_HCMVA
A:
[48-315]
-------------------------------------------------------
Y
G
V
V
F
L
F
G
S
I
G
N
F
L
V
I
F
T
I
---
T
W
R
R
R
I
Q
C
S
G
D
V
Y
F
I
N
L
A
A
A
D
L
L
F
-
V
C
---
T
--
L
P
L
W
M
-
Q
Y
-
L
L
--
D
-------
S
V
P
C
T
L
L
T
A
C
F
Y
V
A
M
F
A
S
L
C
F
I
T
E
I
A
L
D
R
Y
Y
A
I
V
----
Y
M
R
Y
---
R
P
V
K
Q
A
C
L
--
F
S
I
F
W
W
I
F
A
V
I
I
A
-
I
P
H
F
M
V
-
V
T
K
K
D
N
---------
Q
C
M
T
D
Y
D
-
Y
L
E
V
S
Y
--
P
I
I
L
N
V
E
L
M
L
G
A
-
F
V
I
P
L
S
V
I
S
Y
C
Y
Y
----
R
I
-------------
S
R
I
V
A
------------------------------------------------
V
S
Q
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
H
K
-----------
G
--------------
R
I
V
R
V
L
I
A
V
V
L
V
F
I
I
F
W
L
P
Y
H
L
--
T
L
F
V
D
T
L
K
L
L
K
W
I
S
-
S
-
S
C
E
F
E
R
S
L
K
R
A
L
I
L
T
E
S
L
A
F
C
H
C
C
L
N
P
L
L
Y
V
F
V
G
T
K
F
R
Q
E
L
H
C
L
L
A
E
F
R
------------------------------------------------------
18
PsiBlast_PDB
79.26
24%
-162
- C2 -
2VT4
8
ADRB1_MELGA
A:
[14-298]
---------------------------------------------------
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
---
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
---
V
--
V
P
F
G
A
T
L
V
-
V
R
--
G
T
--
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
--
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
-
W
W
R
D
E
D
--
P
Q
A
L
---
K
C
Y
Q
D
P
G
-
C
C
D
F
V
T
--
N
R
A
Y
A
I
A
S
S
I
I
S
-
F
Y
I
P
L
L
I
M
I
F
V
A
L
----
R
V
Y
R
E
A
K
E
Q
IR-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-----------
H
--------------
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
------
F
L
V
N
I
V
N
---
V
F
-
N
-
R
D
L
V
P
---
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
-
F
R
K
A
F
K
R
L
L
A
---------------------------------------------------------
19
PsiBlast_PDB
79.19
24%
-148
- C2 -
2YCW
7
ADRB1_MELGA
A:
[14-298]
---------------------------------------------------
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
---
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
---
V
--
V
P
F
G
A
T
L
V
-
V
R
--
G
T
--
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
--
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
-
W
W
R
D
E
D
--
P
Q
A
L
---
K
C
Y
Q
D
P
G
-
C
C
D
F
V
T
--
N
R
A
Y
A
I
A
S
S
I
I
S
-
F
Y
I
P
L
L
I
M
I
F
V
A
L
----
R
V
Y
R
E
A
K
E
Q
I
R
K
IDR
A
S
K
R
K
------------------------------------------------
R
V
M
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
R
E
-----------
H
--------------
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
------
F
L
V
N
I
V
N
---
V
F
-
N
-
R
D
L
V
P
---
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
-
F
R
K
A
F
K
R
L
L
A
F
--------------------------------------------------------
15
PsiBlast_PDB
78.77
26%
-156
- C2 -
4EA3
3
C562_ECOLX (first)
A:
[125-405]
------------------------------------------------
K
V
T
I
V
G
L
Y
L
A
V
C
V
G
G
L
L
G
N
C
L
V
M
Y
V
I
L
R
H
T
K
M
K
T
A
T
---
N
I
Y
I
F
N
L
A
L
A
D
T
L
V
-
L
L
---
T
--
L
P
F
Q
G
-
T
D
-
I
L
--
L
G
F-
W
P
F
G
N
A
L
C
K
T
V
I
A
I
D
Y
Y
N
M
F
T
S
T
F
T
L
T
A
M
S
V
D
R
Y
V
A
I
C
H
P
----------
T
S
S
K
A
Q
A
--
V
N
V
A
I
W
A
L
A
S
V
V
G
-
V
P
V
A
I
M
-
G
S
A
Q
V
E
--
D
E
E
I
---
E
C
L
V
E
I
P
-
T
P
Q
D
Y
W
--
G
P
V
F
A
I
C
I
F
L
F
S
-
F
I
V
P
V
L
V
I
S
V
C
Y
S
L
M
I
R
R
L
-------------
R
G
V
R
L
LSGS--------------------------------------------
R
E
K
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
N
L
-----------
R
--------------
R
I
T
R
L
V
L
V
V
V
A
V
F
V
G
C
W
T
P
V
Q
V
--
F
V
L
A
Q
G
L
--------
G
-
V
Q
P
S
S
E
T
A
V
A
I
L
R
F
C
T
A
L
G
Y
V
N
S
C
L
N
P
I
L
Y
A
F
L
D
E
N
F
K
A
C
F
R
-------------------------------------------------------------
2
PsiBlast_PDB
78.77
37%
-138
- C2 -
2LNL
-
CXCR1_HUMAN
A:
[36-321]
---------------------------------------------
T
L
N
K
Y
V
V
I
I
A
Y
A
L
V
F
L
L
S
L
L
G
N
S
L
V
M
L
V
I
L
Y
S
R
V
G
R
S
V
T
---
D
V
Y
L
L
N
L
A
L
A
D
L
L
F
-
A
L
---
T
--
L
P
I
W
A
-
A
S
-
K
V
--
N
G
--
W
I
F
G
T
F
L
C
K
V
V
S
L
L
K
E
V
N
F
Y
S
G
I
L
L
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
A
T
---
R
T
---
L
T
Q
K
R
H
L
V
K
F
V
C
L
G
C
W
G
L
S
M
N
L
S
-
L
P
F
F
L
F
-
R
Q
A
Y
H
P
--
N
N
S
S
-
P
-
V
C
Y
E
V
L
G
-
N
D
T
A
K
W
--
R
M
V
L
R
I
L
P
H
T
F
G
-
F
I
V
P
L
F
V
M
L
F
C
Y
G
----
F
T
-------------
L
R
T
L
F
------------------------------------------------
K
A
H
M
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
K
-----------
H
--------------
R
A
M
R
V
I
F
A
V
V
L
I
F
L
L
C
W
L
P
Y
N
L
--
V
L
L
A
D
T
L
M
R
T
Q
-
V
I
-
Q
E
S
C
E
R
R
N
N
I
G
R
A
L
D
A
T
E
I
L
G
F
L
H
S
C
L
N
P
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
L
A
M
H
G
------------------------------------------------------
10
PsiBlast_PDB
78.75
27%
-157
- C2 -
5C1M
7
?
A:
[24-294]
-------------------------------------------------------
Y
S
I
V
C
V
V
G
L
F
G
N
F
L
V
M
Y
V
I
V
R
Y
T
K
M
K
T
A
T
---
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
-
T
S
---
T
--
L
P
F
Q
S
-
V
N
Y
L
M
--
G
T
--
W
P
F
G
N
I
L
C
K
I
V
I
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
C
T
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
R
N
A
K
I
--
V
N
V
C
N
W
I
L
S
S
A
I
G
-
L
P
V
M
-
F
-
M
A
T
T
K
Y
--
R
Q
G
S
-
I
-
D
C
T
L
T
F
S
-
H
P
T
W
Y
W
--
E
N
L
L
K
I
C
V
F
I
F
A
-
F
I
M
P
V
L
I
I
T
V
C
Y
--------------------
G
L
M
I
L
------------------------------------------------
R
L
K
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
M
LSGS
K
E
K
D
R
N
L
R
--------------
R
I
T
R
M
V
L
V
V
V
A
V
F
I
V
C
W
T
P
I
H
I
--
Y
V
I
I
K
A
L
I
T
I
P
-
E
T
-
T
-
F
Q
T
V
S
W
H
F
C
I
A
L
G
Y
T
N
S
------
C
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
--------------------------------------------------------------
13
PsiBlast_PDB
78.61
26%
-159
- C2 -
4RWD
7
C562_ECOLX (first)
A:
[123-400]
-------------------------------------------------
I
A
I
T
A
L
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
M
F
G
I
V
R
Y
T
K
M
K
T
A
T
---
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
-
T
S
---
T
--
L
P
F
Q
S
-
A
K
Y
L
M
--
E
T
--
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
--
I
N
I
C
I
W
V
L
A
S
G
V
G
-
V
P
I
M
V
M
-
A
V
T
R
P
R
---
D
G
A
-
V
-
V
C
M
L
Q
F
P
-
S
P
S
W
Y
W
--
D
T
V
T
K
I
C
V
F
L
F
A
-
F
V
V
P
I
L
I
I
T
V
C
Y
G
----
L
M
-------------
L
L
R
L
R
S
V
RLLSGS----------------------------------------
K
E
K
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
L
-----------
R
--------------
R
I
T
R
M
V
L
V
V
V
G
A
F
V
V
C
W
A
P
I
H
I
--
F
V
I
V
W
T
L
V
D
I
D
-
R
R
-
D
-
P
L
V
V
A
-----
A
L
H
L
C
I
A
L
G
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
Q
L
C
----------------------------------------------------------
12
PsiBlast_PDB
78.13
26%
-157
- C2 -
4RWA
2
C562_ECOLX (first)
A:
[123-400]
-------------------------------------------------
I
A
I
T
A
L
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
M
F
G
I
V
R
Y
T
K
M
K
T
A
T
---
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
-
T
S
---
T
--
L
P
F
Q
S
-
A
K
Y
L
M
--
E
T
--
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
--
I
N
I
C
I
W
V
L
A
S
G
V
G
-
V
P
I
M
V
M
-
A
V
T
R
P
R
---
D
G
A
-
V
-
V
C
M
L
Q
F
P
-
S
P
S
W
Y
W
--
D
T
V
T
K
I
C
V
F
L
F
A
-
F
V
V
P
I
L
I
I
T
V
C
Y
G
----
L
M
-------------
L
L
---GS----------------------------------------------
K
E
K
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
L
-----------
R
--------------
R
I
T
R
M
V
L
V
V
V
G
A
F
V
V
C
W
A
P
I
H
I
--
F
V
I
V
W
T
L
V
D
I
D
-
R
R
-
D
-
P
L
V
V
A
-----
A
L
H
L
C
I
A
L
G
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
Q
L
C
----------------------------------------------------------
4
PsiBlast_PDB
78.02
31%
-174
- C2 -
4XT3
2
US28_HCMVA
A:
[48-315]
-------------------------------------------------------
Y
G
V
V
F
L
F
G
S
I
G
N
F
L
V
I
F
T
I
---
T
W
R
R
R
I
Q
C
S
G
D
V
Y
F
I
N
L
A
A
A
D
L
L
F
-
V
C
---
T
--
L
P
L
W
M
-
Q
Y
-
L
L
--
D
H
-----
A
S
V
P
C
T
L
L
T
A
C
F
Y
V
A
M
F
A
S
L
C
F
I
T
E
I
A
L
D
R
Y
Y
A
I
V
----
Y
M
R
Y
---
R
P
V
K
Q
A
C
L
--
F
S
I
F
W
W
I
F
A
V
I
I
A
-
I
P
H
F
M
V
-
V
T
K
K
D
N
---------
Q
C
M
T
D
Y
D
-
Y
L
E
V
S
Y
--
P
I
I
L
N
V
E
L
M
L
G
A
-
F
V
I
P
L
S
V
I
S
Y
C
Y
Y
----
R
I
-------------
S
R
I
V
A
------------------------------------------------
V
S
Q
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
H
K
-----------
G
--------------
R
I
V
R
V
L
I
A
V
V
L
V
F
I
I
F
W
L
P
Y
H
L
--
T
L
F
V
D
T
L
K
L
L
K
W
I
S
-
S
-
S
C
E
F
E
R
S
L
K
R
A
L
I
L
T
E
S
L
A
F
C
H
C
C
L
N
P
L
L
Y
V
F
V
G
T
K
F
R
Q
E
L
H
C
L
L
A
E
--------------------------------------------------------
30
HHSearch
77.79
17%
-148
- C2 -
3UON
4
ACM2_HUMAN (first)
A:
[22-457]
-----------------------------------------------
E
V
V
F
I
V
L
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
---
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
-
G
V
F--
S
--
M
N
L
Y
T
-
L
Y
-
T
V
I
-
G
Y
--
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
--
M
I
A
A
A
W
V
L
S
F
I
L
W
-
A
P
A
I
L
F
-
W
Q
F
I
V
G
VR
T
V
E
D
-
G
-
E
C
Y
I
Q
F
F
-
S
-------
N
A
A
V
T
F
G
T
A
I
A
A
-
F
Y
L
P
V
I
I
M
T
V
L
Y
W
----
H
I
-------------
S
R
A
S
K
------------------------------------------------
S
R
I
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYPPP--
S
R
E
-----------
K
--------------
K
V
T
R
T
I
L
A
I
L
L
A
F
I
I
T
W
A
P
Y
N
V
--
M
V
L
I
N
T
F
C
A
P
------------
C
I
P
N
T
V
W
T
I
G
Y
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
---------------------------------------------------------
47
Fugue
77.71
19%
-110
- C2 -
1U19
15
OPSD_BOVIN
A:
[4-349]
M
N
G
T
E
G
P
N
FYV
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
------------
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
---
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
-
V
F
GG
F
T
--
T
T
L
Y
T
-
S
L
-
H
G
--
Y
---
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
---
G
-
E
N
H
A
I
M
--
G
V
A
F
T
W
V
M
A
L
A
C
A
-
A
P
P
L
V
G
-
W
S
R
Y
-
I
--
P
E
G
M
-
Q
C
S
C
G
I
D
Y
Y
-
T
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
--
F
I
I
P
L
I
V
I
F
F
C
Y
G
----
Q
L
-------------
V
F
T
V
K
------------------------------------------------
E
A
A
A
QQQESA
T
T
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
E
-----------
K
--------------
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
--
V
A
F
Y
I
F
T
H
Q
G
S
-
D
F
-
G
-
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
--------
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
-------------------------------
C
C
G
K
N
P
L
G
D
D
E
A
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
11
PsiBlast_PDB
77.49
26%
-159
- C2 -
4N6H
23
C562_ECOLX (first)
A:
[126-403]
-------------------------------------------------
I
A
I
T
A
L
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
M
F
G
I
V
R
Y
T
K
M
K
T
A
T
---
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
-
T
S
---
T
--
L
P
F
Q
S
-
A
K
Y
L
M
--
E
T
--
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
--
I
N
I
C
I
W
V
L
A
S
G
V
G
-
V
P
I
M
V
M
-
A
V
T
R
P
R
---
D
G
A
-
V
-
V
C
M
L
Q
F
P
-
S
P
S
W
Y
W
--
D
T
V
T
K
I
C
V
F
L
F
A
-
F
V
V
P
I
L
I
I
T
V
C
Y
G
----
L
M
-------------
L
L
R
L
R
S
V
RLLSGS----------------------------------------
K
E
K
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
L
-----------
R
--------------
R
I
T
R
M
V
L
V
V
V
G
A
F
V
V
C
W
A
P
I
H
I
--
F
V
I
V
W
T
L
V
D
I
D
-
R
R
-
D
-
P
L
V
V
A
-----
A
L
H
L
C
I
A
L
G
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
Q
L
C
R
K
P
C
G
-----------------------------------------------------
31
HHSearch
77.43
37%
-131
- C2 -
2LNL
-
CXCR1_HUMAN
A:
[36-322]
---------------------------------------------
T
L
N
K
Y
V
V
I
I
A
Y
A
L
V
F
L
L
S
L
L
G
N
S
L
V
M
L
V
I
L
Y
S
R
V
G
R
S
V
T
---
D
V
Y
L
L
N
L
A
L
A
D
L
L
F
-
A
L
---
T
--
L
P
I
W
A
-
A
S
-
K
V
--
N
G
--
W
I
F
G
T
F
L
C
K
V
V
S
L
L
K
E
V
N
F
Y
S
G
I
L
L
L
A
C
I
S
V
D
R
Y
L
A
I
V
H
A
T
R
T
L
T
Q
----
K
R
H
L
V
K
F
--
V
C
L
G
C
W
G
L
S
M
N
L
S
-
L
P
F
F
L
F
-
R
Q
A
Y
H
P
--
N
N
S
S
-
P
-
V
C
Y
E
V
L
G
-
N
D
T
A
K
W
--
R
M
V
L
R
I
L
P
H
T
F
G
-
F
I
V
P
L
F
V
M
L
F
C
Y
G
----
F
T
-------------
L
R
T
L
F
------------------------------------------------
K
A
H
M
--------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
K
-----------
H
--------------
R
A
M
R
V
I
F
A
V
V
L
I
F
L
L
C
W
L
P
Y
N
L
--
V
L
L
A
D
T
L
M
R
T
Q
-
V
I
Q
E
-
S
C
E
R
R
N
N
I
G
R
A
L
D
A
T
E
I
L
G
F
L
H
S
C
L
N
P
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
L
A
M
H
G
------------------------------------------------------
27
HHSearch
77.40
22%
-137
- C2 -
2Z73
5
OPSD_TODPA
A:
[27-338]
-----------------------------------------
D
Q
V
P
D
A
V
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
---
N
M
F
I
I
N
L
A
F
S
D
F
T
F
-
S
L
---
V
N
G
F
P
L
M
T
-
I
S
-
C
F
L
-
K
K
--
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
---
M
S
H
R
R
A
F
I
--
M
I
I
F
V
W
L
W
S
V
L
W
A
-
I
G
P
I
F
G
-
W
G
A
Y
T
L
--
E
G
V
L
-
C
-
N
C
S
F
D
Y
I
-
S
R
D
S
-
T
--
T
R
S
N
I
L
C
M
F
I
L
G
-
F
F
G
P
I
L
I
I
F
F
C
Y
F
----
N
I
-------------
V
M
S
V
S
------------------------------------------------
N
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
-----------------------------------------------------------------------------------------------------------------------------------------------
N
A
E
-----------
M
--------------
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
--
V
A
L
L
A
Q
F
G
P
L
-----------
E
W
V
T
P
Y
A
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
Q
F
D
D
K
E
T
E
D
D
K
D
A
E
T
E
I
P
A
G
E
------------------------------