@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : GPR19_HUMAN: (2016-01-10 )
MVFAHRMDNSKPHLIIPTLLVPLQNRSCTETATPLPSQYLMELSEEHSWMSNQTDLHYVLKPGEVATASIFFGILWLFSIFGNSLVCLVIHRSRRTQSTTNYFVVSMACADLLISVASTPFVLLQFTTGRWTLGSATCKVVRYFQYLTPGVQIYVLLSICIDRFYTIVYPLSFKVSREKAKKMIAASWVFDAGFVTPVLFFYGSNWDSHCNYFLPSSWEGTAYTVIHFLVGFVIPSVLIILFYQKVIKYIWRIGTDGRTVRRTMNIVPRTKVKTIKMFLILNLLFLLSWLPFHVAQLWHPHEQDYKKSSLVFTAITWISFSSSASKPTLYSIYNANFRRGMKETFCMSSMKCYRSNAYTITTSSRMAKKNYVGISEIPSMAKTITKDSIYDSFDREAKEKKLAWPINSNPPNTFV
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.....-..130.......140.......150.......160.......170.-..--.-----..--..180.......190--.......200----------.-..--------..------.-...---------210--...--.-----..----.---.220.......230.......240....-----------------...250........260-----------------------------------------------------------------------------------------------------------------------------------------------------.-----------------------------------------------------------------------------------------------------------------------------------------------------.....--..270.......280.......290.......300..-.---....310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
V
F
A
HRMDNSKP
H
L
I
I
P
T
L
L
V
PLQNRSCTETATPL
P
S
Q
Y
L
M
E
L
S
E
E
HSWMSNQT
D
L
H
Y
V
LKPGE
V
A
T
A
S
I
F
F
G
I
L
W
L
F
S
I
FGN
S
L
V
C
L
V
I
HRSRRTQSTT
N
Y
F
V
V
S
M
A
C
A
D
L
L
I
S
VAST
P
F
V
L
L
Q
FT-TG
R
W
TL
G
S
A
T
C
K
V
V
R
Y
F
Q
Y
LTPG
V
Q
I
Y
V
L
L
S
I
C
I
D
R
F
Y
T
I
V
Y
PL-
S
-
F
K
--V-----
S
R
--
E
K
A
K
K
M
I
A
A
S
W
VFDA--G
F
V
T
P
V
L
F
------------
F
-YG--------SN------W-DSH---------C
N
---
Y
FL--P-----SS----W---E
G
T
A
Y
T
V
I
H
F
L
V
G
F
V
I
P
S
V
L
I
I
L
F
Y
Q
K
V
-----------------
I
K
Y
I
W
-RIGTDGR
T
V
R
------------------------------------------------------------------------------------------------------------------------------------------------------
R
-----------------------------------------------------------------------------------------------------------------------------------------------------
T
MNIV--PRT
K
V
K
T
I
K
M
F
L
I
L
N
L
L
F
L
L
S
W
L
P
F
H
V
A
Q
LWHP
H
E
Q
D-Y---KKS
S
L
V
F
T
A
I
T
W
I
S
FSSSASK
P
T
L
Y
S
I
YN
A
N
F
RRG
M
K
E
T
F
C
M
S
S
M
K
C
YRSN
A
Y
T
I
TTSSRMAKKNYV
G
I
S
E
I
P
S
M
A
K
T
I
T
K
D
S
I
Y
D
S
F
D
R
E
A
KEK
K
L
AWPINSNPPNTFV
40
HHSearch
93.25
27%
-120
- C7 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
-------------------------------------------------------------------
Y
A
L
S
Y
C
A
L
I
L
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
M
P
W
V
V
Y
L
E
V
T
G
G
V
W
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
-
H
-
Y
Q
--
H
G
T
G
Q
S
S
C
--
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
--
A
V
S
C
P
L
L
F
------------
G
-
F
N
--------
T
T
G-----
D
-
P
T
V
---------
C
S
---
I
S
N
--
P
------------------
D
F
V
I
Y
S
S
V
V
S
F
Y
L
P
F
G
V
T
V
L
V
Y
A
R
I
-----------------
Y
V
V
L
K
-
Q
R
R
R
K
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
----------------
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTW------------------------------------------------------------------------------------------------------------------------------------
D
A
Y
G
V
--
P
L
R
E
K
K
A
T
Q
M
V
A
I
V
L
G
A
F
I
V
C
W
L
P
F
F
L
T
H
V
L
N
T
H
C
Q
T
-
C
---
H
V
S
P
E
L
Y
S
A
T
T
W
L
G
Y
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
S
C
--------------------------------------------------------------------
31
HHSearch
89.76
26%
-114
- C7 -
3UON
4
ACM2_HUMAN (first)
A:
[24-457]
-----------------------------------------------------------------
V
F
I
V
L
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
M
N
L
Y
T
L
Y
T
V
-
I
G
Y
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
-
T
-
Y
P
VK
R
-----
T
T
--
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
--
I
L
W
A
P
A
I
L
------------
F
-
W
Q
--------
F
I
V
GVRTV
E
-
D
G
E
---------
C
Y
---
I
Q
F
--
F
-----
S
----------
N
A
A
V
T
F
G
T
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
-----------------
S
R
A
S
K
-
S
R
I
N
I
F
E
M
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
P
P
--
P
S
R
E
K
K
V
T
R
T
I
L
A
I
L
L
A
F
I
I
T
W
A
P
Y
N
V
M
V
L
I
N
T
F
C
A
P
-----
C
I
P
N
T
V
W
T
I
G
Y
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
---------------------------------------------------------------------
32
HHSearch
85.71
25%
-112
- C7 -
2RH1
16
ADRB2_HUMAN (first)
A:
[40-477]
----------------------------------------------------------------
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
H
I
L
-
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
-
K
-
Y
Q
SL
L
-----
T
K
--
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
--
L
T
S
F
L
P
I
Q
------------
M
H
W
Y
--------
R
A
TH
Q
---
E
-
A
I
N
---------
C
Y
---
A
E
E
TC
C
-----
D
F
----
F
---
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
-----------------
F
Q
E
A
K
-
R
Q
L
N
I
F
E
M
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
K
F
--
C
L
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
-----
L
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
--------------------------------------------------------------------
51
Fugue
84.71
19%
-75
- C7 -
1F88
8
OPSD_BOVIN
A:
[1-348]
------
M
N
G
T
E
G
----
P
N
F
Y
V
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
------------------
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
-
F
R
--
F
-----
G
E
--
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
--
A
C
A
A
P
P
L
V
GW
S
R
--------
Y
-
I
P
--------
E
G
------
M
-
Q
C
S
---------
C
G
I
DY
Y
T
P
--
H
-----
E
E
----
T
---
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
-----------------
V
F
T
V
K
-
E
A
A
A
S
A
T
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
-
S
---
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
-----------------------------------------
N
P
S
T
T
V
S
K
T
E
T
-----
S
Q
V
A
P
A
---
8
PsiBlast_PDB
81.82
26%
-117
- C7 -
4AMJ
12
ADRB1_MELGA
A:
[12-297]
-----------------------------------------------------------------
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
-
R
-
Y
Q
S
L
M
-----
T
R
--
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
-
P
I
M
M
------------
H
-
W
W
--------
R
D
------
E
-
D
P
Q
A
L
K
C
Y
Q
DPG
C
C
---
D
F
V
--
T
-----
N
R
----
A
---
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
-----------------
K
E
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
M
--
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
-
L
---
V
P
D
W
L
-
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
---------------------------------------------------------------------
13
PsiBlast_PDB
81.75
25%
-109
- C7 -
4BVN
11
ADRB1_MELGA
A:
[12-297]
-----------------------------------------------------------------
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
V
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
-
R
-
Y
Q
S
L
M
-----
T
R
--
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
-
P
I
M
M
------------
H
-
W
W
--------
R
D
------
E
-
D
P
Q
A
L
K
C
Y
Q
DPG
C
C
---
D
F
V
--
T
-----
N
R
----
A
---
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
-----------------
K
E
Q
I
R
---------
K
R
------------------------------------------------------------------------------------------------------------------------------------------------------
K
-----------------------------------------------------------------------------------------------------------------------------------------------------
T
S
R
V
M
--
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
-
L
---
V
P
K
W
L
-
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
L
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
---------------------------------------------------------------------
9
PsiBlast_PDB
81.13
26%
-116
- C7 -
3ZPQ
11
ADRB1_MELGA
A:
[12-297]
-----------------------------------------------------------------
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
-
R
-
Y
Q
S
L
M
-----
T
R
--
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
-
P
I
M
M
------------
H
-
W
W
--------
R
D
------
E
-
D
P
Q
A
L
K
C
Y
Q
DPG
C
C
---
D
F
V
--
T
-----
N
R
----
A
---
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
-----------------
K
E
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
M
--
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
-
L
---
V
P
D
W
L
-
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
---------------------------------------------------------------------
39
HHSearch
81.08
22%
-113
- C7 -
3EML
13
ENLYS_BPT4
A:
[21-472]
----------------------------------------------------------------
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
I
P
F
A
I
T
I
S
T
---
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
-
R
-
Y
N
G
L
V
-----
T
G
--
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
--
A
I
G
L
T
P
M
L
------------
G
-
W
N
--------
N
C
------
G
Q
S
Q
G
---------
C
G
---
E
G
Q
--
V
ACLFE
D
V
----
V
---
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
-----------------
F
L
A
A
R
-
R
Q
L
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
-----------------------------------------------------------------------------------------------------------------------------------------------------
A
Y
R
S
T
--
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
---
H
A
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
---------------------------------------------------------------
7
PsiBlast_PDB
81.05
26%
-122
- C7 -
2Y03
9
ADRB1_MELGA
A:
[12-297]
-----------------------------------------------------------------
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
-
R
-
Y
Q
S
L
M
-----
T
R
--
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
-
P
I
M
M
------------
H
-
W
W
--------
R
D
------
E
-
D
P
Q
A
L
K
C
Y
Q
DPG
C
C
---
D
F
V
--
T
-----
N
R
----
A
---
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
-----------------
K
E
Q
I
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
M
--
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
-
L
---
V
P
D
W
L
-
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
---------------------------------------------------------------------
15
PsiBlast_PDB
80.77
26%
-113
- C7 -
2YCW
7
ADRB1_MELGA
A:
[12-295]
-----------------------------------------------------------------
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
-
R
-
Y
Q
SL
M
-----
T
R
--
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
-
P
I
M
M
------------
H
-
W
W
--------
R
D
------
E
-
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
---
D
F
V
--
T
-----
N
R
----
A
---
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
-----------------
K
E
Q
I
R
-
K
I
---
D
R
A
S
K
------------------------------------------------------------------------------------------------------------------------------------------------------
R
-----------------------------------------------------------------------------------------------------------------------------------------------------
K
R
V
M
L
--
M
R
E
H
-
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
-
L
---
V
P
D
W
L
-
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
--------------------------------------------------------------------
52
Fugue
80.58
19%
-75
- C7 -
1U19
15
OPSD_BOVIN
A:
[4-349]
------
M
N
G
T
E
G
----
P
N
F
Y
V
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
------------------
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
-
S
N
F
R
--
F
-----
G
E
--
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
--
A
C
A
A
P
P
L
V
GW
S
R
Y
I
P
E
GMQC
S
-
C
G
--------
I
D
------
Y
------------------
Y
T
P
--
H
-----
E
E
----
T
---
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
-----------------
V
F
T
V
-----
K
E
A
A
A
Q
Q
------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
T
T
--
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
-
S
---
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
-----------------------------------------
N
P
L
G
D
D
E
A
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
--
12
PsiBlast_PDB
80.53
26%
-123
- C7 -
4MQT
2
ACM2_HUMAN
A:
[36-330]
------------------------------------------------------------
K
T
F
E
V
V
F
I
V
L
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
M
N
L
Y
T
L
Y
T
V
-
I
G
Y
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
-
T
-
Y
P
--
V
-----
K
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
--
I
L
W
A
P
A
I
L
------------
F
-
W
Q
F
I
V
GVRTV
E
D
------
G
-
E
C
Y
---------
I
Q
---
F
F
-------------------
S
N
A
A
V
T
F
G
T
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
-----------------
S
R
A
S
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
R
E
K
K
V
T
R
T
I
L
A
I
L
L
A
F
I
I
T
W
A
P
Y
N
V
M
V
L
I
N
T
F
C
A
P
-
C
---
I
P
N
T
-
V
W
T
I
G
Y
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
C
--------------------------------------------------------------------
17
PsiBlast_PDB
80.50
26%
-113
- C7 -
2YCZ
2
ADRB1_MELGA
A:
[12-295]
-----------------------------------------------------------------
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
-
R
-
Y
Q
S
L
M
-----
T
R
--
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
-
P
I
M
M
------------
H
-
W
W
--------
R
D
------
E
-
D
P
Q
A
L
K
C
Y
Q
DPG
C
C
---
D
F
V
--
T
-----
N
R
----
A
---
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
-----------------
K
E
Q
I
R
-
K
I
---
D
R
A
S
K
------------------------------------------------------------------------------------------------------------------------------------------------------
R
-----------------------------------------------------------------------------------------------------------------------------------------------------
K
R
V
M
L
--
M
R
E
H
-
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
-
L
---
V
P
D
W
L
-
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
--------------------------------------------------------------------
14
PsiBlast_PDB
80.48
26%
-117
- C7 -
2VT4
8
ADRB1_MELGA
A:
[12-295]
-----------------------------------------------------------------
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
-
R
-
Y
Q
S
L
M
-----
T
R
--
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
-
P
I
M
M
------------
H
-
W
W
--------
R
D
------
E
-
D
P
Q
A
L
K
C
Y
Q
DPG
C
C
---
D
F
V
--
T
-----
N
R
----
A
---
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
-----------------
K
E
Q
I
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
-
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
-
L
---
V
P
D
W
L
-
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
---------------------------------------------------------------------
10
PsiBlast_PDB
80.44
26%
-119
- C7 -
3ZPR
11
ADRB1_MELGA
A:
[12-297]
-----------------------------------------------------------------
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
-
R
-
Y
Q
S
L
M
-----
T
R
--
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
-
P
I
M
M
------------
H
-
W
W
--------
R
D
------
E
-
D
P
Q
A
L
K
C
Y
Q
DPG
C
C
---
D
F
V
--
T
-----
N
R
----
A
---
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
-----------------
K
E
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
-
L
---
V
P
D
W
L
-
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
----------------------------------------------------------------------
11
PsiBlast_PDB
79.83
26%
-124
- C7 -
4MQS
1
?
A:
[36-330]
------------------------------------------------------------
K
T
F
E
V
V
F
I
V
L
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
M
N
L
Y
T
L
Y
T
V
-
I
G
Y
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
-
T
-
Y
P
--
V
-----
K
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
--
I
L
W
A
P
A
I
L
------------
F
-
W
Q
F
I
V
GVRTV
E
D
------
G
-
E
C
Y
---------
I
Q
---
F
F
-------------------
S
N
A
A
V
T
F
G
T
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
-----------------
S
R
A
S
K
S---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PP
P
S
R
E
K
K
V
T
R
T
I
L
A
I
L
L
A
F
I
I
T
W
A
P
Y
N
V
M
V
L
I
N
T
F
C
A
P
-
C
---
I
P
N
T
-
V
W
T
I
G
Y
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
---------------------------------------------------------------------
36
HHSearch
79.72
24%
-108
- C7 -
2KS9
1
NK1R_HUMAN
A:
[32-324]
----------------------------------------------------------------
I
V
L
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
T
V
V
N
F
T
Y
A
V
-
H
N
E
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
-
Q
-
P
R
--
L
-----
S
A
--
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
--
L
L
A
F
P
Q
G
Y
------------
Y
-
S
T
--------
T
E
TMP---
S
-
R
V
V
---------
C
M
---
I
E
W
--
P
-----
E
H
----
P
NKI
Y
E
K
V
Y
H
I
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
-----------------
G
I
T
L
W
-
A
S
E
I
P
G
D
S
S
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
H
E
Q
--
V
S
A
K
R
K
V
V
K
M
M
I
V
V
V
C
T
F
A
I
C
W
L
P
F
H
I
F
F
L
L
P
Y
I
N
P
D
-
L
YLK
K
F
I
Q
Q
V
Y
L
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
R
C
C
P
F
I
S
A
G
D
Y
E
G
L
E
M
K
S
T
R
Y
L
Q
T
Q
G
S
V
Y
K
V
S
R
L
E
T
T
I
S
T
V
V
G
A
--------------------------
18
PsiBlast_PDB
79.51
26%
-112
- C7 -
2YCY
6
ADRB1_MELGA
A:
[12-295]
-----------------------------------------------------------------
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
-
R
-
Y
Q
S
L
M
-----
T
R
--
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
-
P
I
M
M
------------
H
-
W
W
--------
R
D
------
E
-
D
P
Q
A
L
K
C
Y
Q
DPG
C
C
---
D
F
V
--
T
-----
N
R
----
A
---
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
-----------------
K
E
Q
I
R
------
D
R
A
S
K
------------------------------------------------------------------------------------------------------------------------------------------------------
R
-----------------------------------------------------------------------------------------------------------------------------------------------------
K
R
V
M
L
--
M
R
E
H
-
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
-
L
---
V
P
D
W
L
-
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
--------------------------------------------------------------------
1
PsiBlast_PDB
79.04
24%
-113
- C7 -
3SN6
1
ENLYS_BPT4
R:
[156-490]
--------------------------------
T
P
N
R
A
K
R
V
I
T
T
F
R
T
G
T
W
D
A
----
E
V
W
V
V
G
M
G
------
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
H
I
L
-
T
K
T
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
-
K
-
Y
Q
SL
L
-----
T
K
--
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
LT
S
F
L
P
I
Q
M
H
------------
W
-
Y
R
------------------
Q
E
A
---------
I
N
---
C
Y
A
--
E
-----
E
T
CCDF
F
---
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
FQEAKRQLQKIDKSEGR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
--
L
K
E
H
-
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
-
L
---
I
R
K
E
-
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
---------------------------------------------------------------------
16
PsiBlast_PDB
79.00
26%
-107
- C7 -
2YCX
3
ADRB1_MELGA
A:
[12-294]
-----------------------------------------------------------------
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
-
R
-
Y
Q
S
L
M
-----
T
R
--
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
-
P
I
M
M
------------
H
-
W
W
--------
R
D
------
E
-
D
P
Q
A
L
K
C
Y
Q
DPG
C
C
---
D
F
V
--
T
-----
N
R
----
A
---
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
-----------------
K
E
Q
I
R
-
K
I
---
D
R
A
S
K
------------------------------------------------------------------------------------------------------------------------------------------------------
R
-----------------------------------------------------------------------------------------------------------------------------------------------------
K
R
V
M
L
--
M
R
E
H
-
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
-
L
---
V
P
D
W
L
-
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
-------------------------------------------------------------------------