@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : HCAR1_HUMAN: (2016-01-10 )
MYNGSCCRIEGDTISQVMPPLLIVAFVLGALGNGVALCGFCFHMKTWKPSTVYLFNLAVADFLLMICLPFRTDYYLRRRHWAFGDIPCRVGLFTLAMNRAGSIVFLTVVAADRYFKVVHPHHAVNTISTRVAAGIVCTLWALVILGTVYLLLENHLCVQETAVSCESFIMESANGWHDIMFQLEFFMPLGIILFCSFKIVWSLRRRQQLARQARMKKATRFIMVVAIVFITCYLPSVSARLYFLWTVPSSACDPSVHGALHITLSFTYMNSMLDPLVYYFSSPSFPKFYNKLKICSLKPKQPGHSKTQRPEEMPISNLGRRSCISVANSFQSQSDGQWDPHIVEWH
Atome Classification :
(20 SA)
----------------------.........10........20........30........40........50........60...-.-.-.--..70-........80........90........100.......110.......120....---...130.......140.......150.-...--..---.160.------...----.-----.-------..170----........----180--....----.....190...----....200.------------------------------------------------.-----.....----------------------------------------------------------------------------------------------------------------------------------------------------------------210--------------------------------------------------------------------------------------------------------------------------------------------------------------......--...220.......230...-------....240....-...250---.........260.....-..270.......280.......290--........--300.......310.......320.......330.......340....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------MYNG
S
C
C
R
IEG
D
T
I
S
Q
V
M
P
P
L
L
I
V
A
F
V
L
G
ALGN
G
V
A
L
C
G
F
C
FHMKTWKP
S
T
V
Y
L
F
N
L
A
V
A
D
F
L
L
-
M
-
I
-
C
--LPFR-T
D
Y
Y
L
R
RRHWAFGDIPCR
V
G
L
F
T
L
A
MNRAG
S
I
V
F
L
T
V
VAAD
R
Y
F
K
V
VHPHH
A
V
N
T
---
I
S
T
R
V
A
A
G
I
V
C
T
L
W
A
L
V
I
L
G
T
V
Y
L
L
L
E-NHL--
C
V
---
Q
E
T
-
A
------
V
S
C
----
E
-----
S
-------
F
I
M
E
-----SAN
G
W
H
D
I
----
M
----
F
Q
L
E
----
F
F
M
P
L
G
I
I
L
F
C
----
S
F
K
I
V
W
S
L
------------------------------------------------
R
-----
R
R
Q
Q
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Q
A
R
M
K
--
K
A
T
R
F
I
M
V
V
A
I
V
F
I
T
C
YLP-------SVS
A
R
L
Y
F
L
W
T-VPSS-----ACDPSVH
G
A
L
H
I
T
L
S
F
T
-
Y
M
N
S
M
L
D
P
L
V
Y
Y
FSSP
S
F
P
K
F
Y
N
K---L
K
I
C
SLKP--KQPGHSKTQRPEEM
P
I
S
N
LG
R
R
S
C
I
S
V
A
N
S
FQSQSDGQWDPHIVEWH
41
Fugue
93.09
28%
-140
- C2 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
------------------------
S
F
K
C
A
L
T
K
T
G
F
Q
F
Y
Y
L
P
A
V
Y
I
L
V
F
I
I
G
F
L
G
N
S
V
A
I
W
M
F
V
F
H
M
K
P
W
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
-
V
-
L
-
T
--
L
P
A
L
-
I
F
Y
Y
F
N
K
T
D
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
K
-
S
L
G
R
---
L
K
K
K
N
A
I
C
I
S
V
L
V
W
L
I
V
V
V
A
I
S
P
I
L
F
Y
-
S
G
T
--
G
V
---
R
K
N
K
T
------
I
T
C
YDTT
S
-----
D
-------
E
Y
L
R
-----
S
Y
F
I
Y
S
M
C
----
T
----
T
V
A
M
----
F
C
V
P
L
V
L
I
L
G
C
----
Y
G
L
I
V
R
A
L
I
Y
K
M
K
K
Y
T
C
TVCG
Y
I
Y
N
PEDGDPDNGVNPGTDFKDIVCPLCGVG----
K
-----
D
Q
F
E
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
P
L
R
R
--
K
S
I
Y
L
V
I
I
V
L
T
V
F
A
V
S
Y
I
P
F
H
V
M
K
--
T
M
N
L
R
A
R
L
D
F
Q
-
T
P
A
M
C
----
A
F
N
D
R
V
Y
A
T
Y
Q
V
T
R
G
L
A
-
S
L
N
S
C
V
N
P
I
L
Y
F
L
A
G
D
T
F
R
R
R
---------------------------------------------------------------
2
PsiBlast_PDB
90.29
24%
-135
- C2 -
4XNW
2
RUBR_CLOPA
A:
[53-382]
---------------------------------------
L
P
A
V
Y
I
L
V
F
I
I
G
F
L
G
N
S
V
A
I
W
M
F
V
F
H
M
K
P
W
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
-
V
-
L
-
T
--
L
P
A
L
-
I
F
Y
Y
F
N
K
T
D
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
L
K
S
L
G
R
---
L
K
K
K
N
A
I
C
I
S
V
L
V
W
L
I
V
V
V
A
I
S
P
I
L
F
Y
-
S
G
T
--
G
V
---
R
K
N
K
T
------
I
T
C
----
Y
-----
D
-------
T
T
S
D
-----
E
Y
L
R
S
Y
F
I
----
Y
----
S
M
C
T
T
V
A
M
F
C
V
P
L
V
L
I
L
G
C
----
Y
G
L
I
V
R
A
L
I
Y
K
M
K
K
Y
T
C
TVCG
Y
I
Y
N
PEDGDPDNGVNPGTDFKDIPDDWVCPLCGVG
K
-----
D
Q
F
E
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
P
L
R
R
--
K
S
I
Y
L
V
I
I
V
L
T
V
F
A
V
S
Y
I
P
F
H
V
M
K
T
M
N
L
R
A
R
L
D
F
-
Q
T
-
P
A
M
C
-----
A
F
N
D
R
V
Y
A
T
Y
Q
V
T
R
G
L
A
-
S
L
N
S
C
V
N
P
I
L
Y
F
L
A
G
D
T
F
R
R
---
R
------------------------------------------------------------
1
PsiBlast_PDB
88.41
24%
-138
- C2 -
4XNV
15
P2RY1_HUMAN (first)
A:
[53-382]
---------------------------------------
L
P
A
V
Y
I
L
V
F
I
I
G
F
L
G
N
S
V
A
I
W
M
F
V
F
H
M
K
P
W
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
-
V
-
L
-
T
--
L
P
A
L
-
I
F
Y
Y
F
N
K
T
D
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
-
K
S
L
G
R
---
L
K
K
K
N
A
I
C
I
S
V
L
V
W
L
I
V
V
V
A
I
S
P
I
L
F
Y
-
S
G
T
--
G
V
---
R
K
N
K
T
------
I
T
C
----
Y
-----
D
-------
T
T
S
D
-----
E
Y
L
R
S
Y
F
I
----
Y
----
S
M
C
T
T
V
A
M
F
C
V
P
L
V
L
I
L
G
C
----
Y
G
L
I
V
R
A
L
I
Y
K
M
K
K
Y
T
C
TVCG
Y
I
Y
N
PEDGDPDNGVNPGTDFKDIVCPLCGVG----
K
-----
D
Q
F
E
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
P
L
R
R
--
K
S
I
Y
L
V
I
I
V
L
T
V
F
A
V
S
Y
I
P
F
H
V
M
K
T
M
N
L
R
A
R
L
D
F
-
Q
T
-
P
A
M
C
-----
A
F
N
D
R
V
Y
A
T
Y
Q
V
T
R
G
L
A
-
S
L
N
S
C
V
N
P
I
L
Y
F
L
A
G
D
T
F
R
R
---
R
------------------------------------------------------------
25
HHSearch
86.13
21%
-126
- C2 -
2Z73
5
OPSD_TODPA
A:
[31-336]
---------------------------------
D
A
V
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
-
S
-
L
-
V
N
G
F
P
L
M
-
T
I
S
C
-
F
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
---
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
-
W
G
A
--
Y
T
L
--
E
G
V
-
L
------
C
N
C
----
S
-----
F
-------
D
Y
I
S
RD
S
--
T
T
R
S
N
I
L
C
----
M
----
F
I
L
G
----
F
F
G
P
I
L
I
I
F
F
C
----
Y
F
N
I
V
M
S
V
------------------------------------------------
S
-----
N
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
-----------------------------------------------------------------------------------------------------------------------------------------------
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------
G
A
N
A
E
M
--
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
-------
Y
A
V
V
A
L
L
A
Q
F
G
-
P
L
E
---------
W
V
T
P
Y
A
A
Q
L
P
V
M
F
A
-
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
---
T
F
P
W
V
L
T
C
--
C
Q
F
D
D
K
E
T
E
D
D
K
D
A
E
T
E
I
P
A
G
E
-------------------------
33
HHSearch
85.25
23%
-131
* C2 *
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
---------------------------------------
Y
A
L
S
Y
C
A
L
I
L
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
-
A
-
T
L
V
--
M
P
W
V
-
V
Y
L
E
V
T
G
G
V
W
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
P
L
L
F
G
-
F
N
T
--
T
G
-----
D
-
P
------
T
V
C
----
S
-----
I
-------
S
N
P
---------
D
F
V
I
Y
----
S
----
S
V
V
S
----
F
Y
L
P
F
G
V
T
V
L
V
----
Y
A
R
I
Y
V
V
L
------------------------------------------------
K
-----
Q
R
R
R
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWDAYG
V
P
L
R
E
K
--
K
A
T
Q
M
V
A
I
V
L
G
A
F
I
V
C
W
L
P
-------
F
F
L
T
H
V
L
N
T
H
C
-
Q
T
C
---------
H
V
S
P
E
L
Y
S
A
T
T
W
L
G
-
Y
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
---
I
L
S
C
-----------------------------------------------------
3
PsiBlast_PDB
84.87
27%
-135
- C2 -
4EA3
3
C562_ECOLX (first)
A:
[137-405]
------------------------------------------------
V
G
G
L
L
G
N
C
L
V
M
Y
V
I
L
R
H
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
T
L
V
-
L
-
L
-
T
--
L
P
F
Q
G
T
D
I
L
L
G
--
F
W
P
F
G
N
A
L
C
K
T
V
I
A
I
D
Y
Y
N
M
F
T
S
T
F
T
L
T
A
M
S
V
D
R
Y
V
A
I
C
H
P
----------
T
S
S
K
A
Q
A
V
N
V
A
I
W
A
L
A
S
V
V
G
V
P
V
A
I
M
-
G
S
A
--
Q
V
---
E
D
E
-
E
------
I
E
C
----
L
-----
V
-------
E
I
P
T
-----
P
Q
D
Y
W
G
P
V
F
A
I
C
I
----
F
L
F
S
----
F
I
V
P
V
L
V
I
S
V
C
----
Y
S
L
M
I
R
R
L
------------------------------------------------
R
-----
G
V
R
L
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
GSRE------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
R
N
L
R
--
R
I
T
R
L
V
L
V
V
V
A
V
F
V
G
C
W
T
P
V
------
Q
V
F
V
L
A
Q
G
L
G
V
-
Q
P
S
S
-----
E
T
A
V
A
I
---
L
R
F
C
T
A
L
G
-
Y
V
N
S
C
L
N
P
I
L
Y
A
F
L
D
E
N
F
K
A
C
F
R
-------------------------------------------------------------
44
Fugue
83.90
19%
-102
- C2 -
1F88
8
OPSD_BOVIN
A:
[1-348]
MN
G
T
E
G
PNFYVPFSNKTGVVRS
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
-
V
-
F
-
G
--
G
F
T
T
-
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
---
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
-
S
R
Y
--
I
P
---
E
G
M
-
Q
------
C
S
C
----
G
I
DYYT
P
-------
H
E
E
T
-----
N
N
E
S
F
V
I
Y
----
M
----
F
V
V
H
----
F
I
I
P
L
I
V
I
F
F
C
----
Y
G
Q
L
V
F
T
V
------------------------------------------------
K
-----
E
A
A
A
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T---------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Q
K
A
E
K
--
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
-------
Y
A
G
V
A
F
Y
I
F
T
H
-
Q
G
S
---------
D
F
G
P
I
F
M
T
I
P
A
F
F
A
-
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
---
T
L
C
C
G
K
N
P
--
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
--------------------------------
4
PsiBlast_PDB
83.79
27%
-133
- C2 -
4RWA
2
C562_ECOLX (first)
A:
[135-405]
-------------------------------------------------
V
G
L
L
G
N
V
L
V
M
F
G
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
-
T
-
S
-
T
--
L
P
F
Q
-
S
A
K
Y
L
-
M
E
T
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
S
G
V
G
V
P
I
M
V
M
-
A
V
T
--
R
P
---
R
D
G
-
A
------
V
V
C
----
M
-----
L
-------
Q
F
P
S
-----
P
S
W
Y
W
D
T
V
T
K
I
C
V
----
F
L
F
A
----
F
V
V
P
I
L
I
I
T
V
C
Y
G
L
M
L
L
--------------------------------------------------------------
G
S
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
R
S
L
R
--
R
I
T
R
M
V
L
V
V
V
G
A
F
V
V
C
W
A
P
---------
I
H
I
F
V
I
V
W
T
L
V
D
I
D
-----
R
R
D
P
L
V
V
A
A
L
H
L
C
I
A
L
G
-
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
Q
---
L
C
-------------------------------------------------------
5
PsiBlast_PDB
83.35
27%
-127
- C2 -
4RWD
6
C562_ECOLX (first)
A:
[135-405]
-------------------------------------------------
V
G
L
L
G
N
V
L
V
M
F
G
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
-
T
-
S
-
T
--
L
P
F
Q
-
S
A
K
Y
L
-
M
E
T
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
S
G
V
G
V
P
I
M
V
M
-
A
V
T
--
R
P
---
R
D
G
-
A
------
V
V
C
----
M
-----
L
-------
Q
F
P
S
-----
P
S
W
Y
W
D
T
V
T
K
I
C
V
----
F
L
F
A
----
F
V
V
P
I
L
I
I
T
V
C
Y
G
L
M
L
L
R
L
R
S
V
R
------------------------------------------------
L
-----
L
S
G
S
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
R
S
L
R
--
R
I
T
R
M
V
L
V
V
V
G
A
F
V
V
C
W
A
P
---------
I
H
I
F
V
I
V
W
T
L
V
D
I
D
-----
R
R
D
P
L
V
V
A
A
L
H
L
C
I
A
L
G
-
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
Q
---
L
C
-------------------------------------------------------
6
PsiBlast_PDB
83.17
27%
-130
- C2 -
4N6H
21
OPRD_HUMAN
A:
[138-408]
-------------------------------------------------
V
G
L
L
G
N
V
L
V
M
F
G
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
-
T
-
S
-
T
--
L
P
F
Q
-
S
A
K
Y
L
-
M
E
T
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
L
A
S
G
V
G
V
P
I
M
V
M
-
A
V
T
--
R
P
---
R
D
G
-
A
------
V
V
C
----
M
-----
L
-------
Q
F
P
S
-----
P
S
W
Y
W
D
T
V
T
K
I
C
V
----
F
L
F
A
----
F
V
V
P
I
L
I
I
T
V
C
Y
G
L
M
L
L
R
L
R
S
V
R
------------------------------------------------
L
-----
L
S
G
S
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
R
S
L
R
--
R
I
T
R
M
V
L
V
V
V
G
A
F
V
V
C
W
A
P
---------
I
H
I
F
V
I
V
W
T
L
V
D
I
D
-----
R
R
D
P
L
V
V
A
A
L
H
L
C
I
A
L
G
-
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
Q
---
L
C
R
K
P
C
G
--------------------------------------------------
22
HHSearch
83.12
19%
-129
- C2 -
3ODU
6
CXCR4_HUMAN (first)
A:
[43-498]
-------------------------------
N
A
N
F
N
K
I
F
L
P
T
I
Y
S
I
I
F
L
T
G
I
V
G
N
G
L
V
I
L
V
M
G
Y
Q
K
K
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
-
V
-
I
-
T
--
L
P
F
W
-
A
V
D
A
V
--
A
N
W
Y
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
N
S
Q
R
P
---
R
K
L
L
A
E
K
V
V
Y
V
G
V
W
I
P
A
L
L
L
T
I
P
D
F
I
F
-
A
N
V
--
S
E
---
A
D
D
-
R
------
Y
I
C
----
D
-----
R
-------
F
Y
P
N
D
L
---
W
V
V
V
F
Q
F
Q
----
H
----
I
M
V
G
----
L
I
L
P
G
I
V
I
L
S
C
----
Y
C
I
I
I
S
K
L
------------------------------------------------
S
-----
H
S
G
S
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYG
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
H
Q
K
R
--
K
A
L
K
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
-------
Y
Y
I
G
I
S
I
D
S
F
I
-
L
L
E
I
I
K
Q
G
C
E
F
E
N
T
V
H
K
W
I
S
I
T
E
A
L
A
-
F
F
H
C
C
L
N
P
I
L
Y
A
F
L
G
A
K
F
K
T
S
A
Q
H
---
A
L
T
S
G
R
P
L
--
E
V
L
F
Q
------------------------------------------
26
HHSearch
81.96
20%
-128
- C2 -
3RZE
5
ENLYS_BPT4 (first)
A:
[9-443]
-------------------------------------
M
P
L
V
V
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
-
G
-
A
V
V
--
M
P
M
N
-
I
L
Y
L
-
L
M
S
K
W
S
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
I
P
I
L
G
W
-
N
H
---------
R
R
-
E
------
D
K
C
----
E
-----
T
-------
D
F
Y
D
------
V
T
W
F
K
V
M
----
T
----
A
I
I
N
----
F
Y
L
P
T
L
L
M
L
W
F
----
Y
A
K
I
Y
K
A
V
------------------------------------------------
R
-----
Q
H
C
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAY--
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
N
R
E
R
--
K
A
A
K
Q
L
G
F
I
M
A
A
F
I
L
C
W
I
P
-------
Y
F
I
F
F
M
V
I
A
F
C
-
K
N
----------
C
C
N
E
H
L
H
M
F
T
I
W
L
G
-
Y
I
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
---
I
L
H
I
-----------------------------------------------------
27
HHSearch
81.49
19%
-129
- C2 -
2RH1
16
ADRB2_HUMAN (first)
A:
[38-477]
----------------------------------
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
-
G
-
L
A
V
--
V
P
F
G
-
A
A
H
I
-
L
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
--
A
T
---
H
Q
E
-
A
I
N
C
Y
A
E
E
T
C
----
C
-----
D
-------
F
F
-------
T
N
Q
A
Y
A
I
A
----
S
----
S
I
V
S
----
F
Y
V
P
L
V
I
M
V
F
V
----
Y
S
R
V
F
Q
E
A
------------------------------------------------
K
-----
R
Q
L
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAY--
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------
F
C
L
K
E
H
--
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
-------
F
F
I
V
N
I
V
H
V
I
Q
-
D
N
----------
L
I
R
K
E
V
Y
I
L
L
N
W
I
G
-
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
---
L
L
C
L
-----------------------------------------------------
30
HHSearch
80.83
19%
-122
- C2 -
2KS9
1
NK1R_HUMAN
A:
[33-326]
-------------------------------------
V
L
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
-
A
-
A
F
N
--
T
V
V
N
-
F
T
Y
A
-
V
H
N
E
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
-----
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
-
S
T
T
--
E
T
---
M
P
S
-
R
------
V
V
C
----
M
-----
I
-------
E
W
P
E
HPNKI
Y
E
K
V
Y
H
I
C
----
V
----
T
V
L
I
----
Y
F
L
P
L
L
V
I
G
Y
A
----
Y
T
V
V
G
I
T
L
------------------------------------------------
W
-----
A
S
E
I
P
GDSSDRYH--------------------------------------------------------------------------------------------------------------------------------------------------------
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
V
S
A
K
R
--
K
V
V
K
M
M
I
V
V
V
C
T
F
A
I
C
W
L
P
-------
F
H
I
F
F
L
L
P
Y
I
N
-
P
D
L
Y
-----
L
K
-
K
F
I
Q
Q
V
Y
L
A
I
M
W
L
A
-
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
---
A
F
R
C
C
P
F
I
--
S
A
G
D
Y
E
G
L
E
M
K
S
T
R
Y
L
Q
T
Q
G
S
V
Y
K
V
S
R
L
E
T
T
I
S
T
V
V
G
A
---------
42
Fugue
79.85
19%
-98
- C2 -
1U19
15
OPSD_BOVIN
A:
[4-349]
MN
G
T
E
G
PNFYVPFSNKTGVVRS
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
-
V
-
F
-
G
--
G
F
T
T
-
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
---
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
-
S
R
Y
--
I
P
---
E
G
M
-
Q
------
C
S
C
----
G
I
DYYT
P
-------
H
E
E
T
-----
N
N
E
S
F
V
I
Y
----
M
----
F
V
V
H
----
F
I
I
P
L
I
V
I
F
F
C
----
Y
G
Q
L
V
F
T
V
------------------------------------------------
K
EAAAQ
Q
Q
E
S
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Q
K
A
E
K
--
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
-------
Y
A
G
V
A
F
Y
I
F
T
H
-
Q
G
S
---------
D
F
G
P
I
F
M
T
I
P
A
F
F
A
-
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
---
T
L
C
C
G
K
N
P
LG
D
D
E
A
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
----------------------------
13
PsiBlast_PDB
79.65
22%
-145
- C2 -
4GBR
1
ADRB2_HUMAN
A:
[10-286]
--------------------------------------
I
V
M
S
L
I
V
L
A
I
V
F
G
---
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
-
A
-
V
--
V
P
F
G
-
A
A
H
I
L
T
K
T
-
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
-
T
S
F
L
P
I
Q
-
M
H
W
YR
A
T
---
H
Q
E
-
A
------
I
N
C
----
Y
-----
A
EET
C
C
D
-
F
F
T
N
-----
Q
A
Y
A
I
A
S
S
----
I
------
V
S
----
F
Y
V
P
L
V
I
M
V
F
V
----
Y
S
R
V
F
Q
E
A
------------------------------------------------
K
-----
R
Q
L
Q
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
F
C
L
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
-------------
F
F
I
V
N
-
I
V
H
V
-----
I
Q
D
N
L
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
--------------------------------------------------------
29
HHSearch
79.59
18%
-140
- C2 -
3EML
13
ENLYS_BPT4
A:
[18-472]
---------------------------------
I
M
G
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
-
G
V
L
-
A
--
I
P
F
A
-
I
T
I
S
---
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
-
W
N
N
--
C
G
---
Q
---
S
------
Q
G
C
----
G
-----
E
GQVACLF
E
D
V
V
-----
P
M
N
Y
M
V
Y
F
----
N
----
F
F
A
C
----
V
L
V
P
L
L
L
M
L
G
V
----
Y
L
R
I
F
L
A
A
------------------------------------------------
R
-----
R
Q
L
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
R
-
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
Q
K
E
V
--
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
-------
L
H
I
I
N
C
F
T
F
F
C
-
P
D
C
S
--------
H
A
P
L
W
L
M
Y
L
A
I
V
L
S
-
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
---
I
I
R
S
H
V
L
R
--
Q
----------------------------------------------
7
PsiBlast_PDB
79.15
25%
-134
- C2 -
5C1M
7
?
A:
[29-294]
------------------------------------------------
V
V
G
L
F
G
N
F
L
V
M
Y
V
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
A
L
A
-
T
-
S
-
T
--
L
P
F
Q
-
S
V
N
Y
L
M
G
T
-
W
P
F
G
N
I
L
C
K
I
V
I
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
C
T
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
R
N
A
K
I
V
N
V
C
N
W
I
L
S
S
A
I
G
L
P
V
M
F
M
-
A
T
T
--
K
Y
---
R
Q
G
-
S
------
I
D
C
----
T
-----
L
-------
T
F
S
H
-----
P
T
W
Y
W
E
N
L
----
L
K
I
C
V
F
I
F
A
----
F
I
M
P
V
L
I
I
T
V
C
----
Y
G
L
M
I
L
R
L
------------------------------------------------
K
-----
S
V
R
M
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
GS
K
E
------------------------------------------------------------------------------------------------------------------------------------------------------------
K
D
R
N
L
R
--
R
I
T
R
M
V
L
V
V
V
A
V
F
I
V
C
W
T
P
I
------
H
I
Y
V
I
I
K
A
L
I
T
-
I
P
E
T
-----
T
F
Q
T
V
---
S
W
H
F
C
I
A
L
G
-
Y
T
N
S
C
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
--------------------------------------------------------------
24
HHSearch
78.29
20%
-126
- C2 -
3UON
4
ACM2_HUMAN (first)
A:
[22-457]
-----------------------------------
E
V
V
F
I
V
L
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
-
G
V
F
-
S
--
M
N
L
Y
-
T
L
Y
T
-
V
I
G
Y
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
A
I
L
F
-
W
Q
F
--
I
V
GVR
T
V
E
-
D
------
G
E
C
----
Y
-----
I
-------
Q
F
F
------
S
N
A
A
V
T
F
G
----
T
----
A
I
A
A
----
F
Y
L
P
V
I
I
M
T
V
L
----
Y
W
H
I
S
R
A
S
------------------------------------------------
K
-----
S
R
I
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAY--
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------
P
P
S
R
E
K
--
K
V
T
R
T
I
L
A
I
L
L
A
F
I
I
T
W
A
P
-------
Y
N
V
M
V
L
I
N
T
F
C
-
A
P
----------
C
I
P
N
T
V
W
T
I
G
Y
W
L
C
-
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
---
L
L
M
------------------------------------------------------
31
HHSearch
77.46
21%
-115
- C2 -
1U19
14
OPSD_BOVIN
A:
[36-327]
--------------------------------
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
-
V
-
F
-
G
--
G
F
T
T
-
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
----
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
-
W
S
R
--
Y
I
P
--
E
G
M
-
Q
------
C
S
C
----
G
-----
I
-------
D
Y
Y
T
PHEET
N
N
E
S
F
V
I
Y
----
M
----
F
V
V
H
----
F
I
I
P
L
I
V
I
F
F
C
----
Y
G
Q
L
V
F
T
V
------------------------------------------------
K
-----
E
A
A
A
Q
QQESA-----------------------------------------------------------------------------------------------------------------------------------------------------------
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
Q
K
A
E
K
--
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
-------
Y
A
G
V
A
F
Y
I
F
T
H
-
Q
G
S
---------
D
F
G
P
I
F
M
T
I
P
A
F
F
A
-
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
---
T
L
C
C
G
K
N
P
--
L
G
D
D
E
A
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
--------------------------