@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LPAR1_HUMAN: (2016-01-10 )
MAAISTSIPVISQPQFTAMNEPQCFYNESIAFFYNRSGKHLATEWNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATFRQILCCQRSENPTGPTEGSDRSASSLNHTILAGVHSNDHSVV
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100--.......-110.........120.......130...-....140.......150.......-.---160.......170.......180..-...-..--190---..------.....--------.-------.200..----...-.-.210..--.....220.......230.......240.------------------------------------------------------------------------------------------------------------------------------------------------------.-------------------------------------------------------------------------------------------------------------------------------------------------------.....250.....---..260.......270.......280....--...290.....--..300.......310.......320.......330.......340.......350.......360..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAAISTSIPVISQPQFTAMNEPQ
C
F
YNE
S
I
A
F
F
YNRSG
K
H
L
A
T
E
W
N
T
V
S
K
L
V
M
G
L
G
I
T
V
C
I
F
I
M
L
A
N
L
L
V
M
V
A
I
Y
VN
R
R
FH
F
P
I
Y
Y
L
M
A
N
L
A
A
A
D
F
F
A
G
L
A
Y
--
F
Y
L
M
FNT-G--PN
T
R
R
L
T
V
S
T
W
L
L
R
QGLID
T
S
L
T
A
S
-
V
A
N
L
L
A
I
A
I
E
RH
I
T
V
-
F
R
M
Q
L
H
T
R-M---SN
R
R
V
V
V
V
I
V
V
I
W
T
M
A
I
V
M
GAIPSV-G
W
N
-
C
I
--
C
-----DI------ENCSN--------M-------APLYSD----
S
Y
L
-
V
-
F
W
A
I
F
N
--
L
V
T
F
V
V
M
V
V
L
Y
A
H
I
F
G
Y
V
R
Q
R
T
M
R
M
SRHS------------------------------------------------------------------------------------------------------------------------------------------------------S-------------------------------------------------------------------------------------------------------------------------------------------------------GPRR
N
R
D
T
M
M
S
L
L
---
K
T
V
V
I
V
L
G
A
F
I
I
CWTP
G
L
V
L
L
L
L
D
VCCPQ--
C
D
V
L
A
Y
E
K
F
F
L
--
L
L
A
E
F
N
SAMNP
I
I
Y
S
YRD
K
E
M
S
A
T
F
R
Q
I
L
C
CQRSENPTGPTEGSDRSASSLN
H
T
I
L
A
G
VHSNDHSVV
47
HHSearch
81.82
39%
-161
- C5 -
3V2Y
1
ENLYS_BPT4
A:
[60-495]
---------------------------------------------
E
N
S
I
K
L
T
S
V
V
F
I
L
I
C
C
F
I
I
L
E
N
I
F
V
L
L
T
I
W
K
T
K
K
F
H
R
P
M
Y
Y
F
I
G
N
L
A
L
S
D
L
L
A
G
V
A
Y
--
T
A
N
L
L
L
S
-
G
--
A
T
T
Y
K
L
T
P
A
Q
W
F
L
R
E
G
S
M
F
V
A
L
S
A
S
-
V
F
S
L
L
A
I
A
I
E
R
Y
I
T
M
-
L
K
-----------
N
N
F
R
L
F
L
L
I
S
A
C
W
V
I
S
L
I
L
G
G
L
P
I
M
-
G
W
N
-
C
I
--
S
-----
A
L
------
S
S
C
S
T
--------
V
-------
L
P
L
Y
H
K
----
H
Y
I
-
L
-
F
C
T
T
V
F
--
T
L
L
L
L
S
I
V
I
L
Y
C
R
I
Y
S
L
V
R
T
R
N
I
F
E
M
L
R
I
------------------------------------------------------------------------------------------------------------------------------------------------------
D
EGLRL
K
I
Y
K
D
TE
G
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWD--
A
Y
A
S
R
S
S
E
N
V
A
L
L
---
K
T
V
I
I
V
L
S
V
F
I
A
C
W
A
P
L
F
I
L
L
L
L
D
V
G
C
K
V
KT
C
D
I
L
F
R
A
E
Y
F
L
--
V
L
A
V
L
N
S
G
T
N
P
I
I
Y
T
L
T
N
K
E
M
R
R
A
F
I
R
I
M
G
R
P
L
----------------------------------
3
PsiBlast_PDB
77.24
99%
-175
- C5 -
4Z36
2
C562_ECOLX (first)
A:
[41-250]
----------------------
Q
C
F
Y
N
E
S
I
A
F
F
Y
N
R
S
G
K
H
L
A
T
E
W
N
T
V
S
K
L
V
M
G
L
G
I
T
V
C
I
F
I
M
L
A
N
L
L
V
M
V
A
I
Y
V
N
R
R
F
H
F
P
I
Y
Y
L
M
A
N
L
A
A
A
D
F
F
A
G
L
A
Y
--
F
Y
L
M
F
N
T
-
G
--
P
N
T
R
R
L
T
V
S
T
W
L
L
R
Q
G
L
I
D
T
S
L
T
A
S
-
V
A
N
L
L
A
I
A
I
E
R
H
I
T
V
-
F
R
M
Q
L
H
T
R
-
M
---
S
N
R
R
V
V
V
V
I
V
V
I
W
T
M
A
I
V
M
G
A
I
P
S
V
-
G
W
N
-
C
I
--
C
-----
D
I
------
E
N
C
S
N
--------
M
-------
A
P
L
Y
S
C
----
S
Y
L
-
V
-
F
W
A
I
F
N
--
L
V
T
F
V
V
M
V
V
L
Y
A
H
I
F
G
Y
V
A
D
L
E
D
N
W
E
T
L
N
------------------------------------------------------------------------------------------------------------------------------------------------------
D
-------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
K
V
I
E
K
A
D
N
A
A
Q
---
V
K
D
A
L
T
K
M
R
A
A
A
L
D
A
Q
K
G
M
K
D
F
R
H
G
F
D
I
L
--
V
G
Q
I
D
D
A
L
K
L
A
--
N
E
G
K
V
K
E
A
Q
A
A
A
E
Q
L
K
T
T
R
N
A
Y
I
Q
K
Y
L
R
N
R
D
T
M
M
S
L
L
K
T
V
V
I
V
L
G
A
F
I
I
C
W
T
P
G
L
V
L
L
L
L
D
C
C
C
P
Q
C
1
PsiBlast_PDB
76.44
100%
-175
- C5 -
4Z34
2
C562_ECOLX (first)
A:
[38-250]
-------------------
N
E
P
Q
C
F
Y
N
E
S
I
A
F
F
Y
N
R
S
G
K
H
L
A
T
E
W
N
T
V
S
K
L
V
M
G
L
G
I
T
V
C
I
F
I
M
L
A
N
L
L
V
M
V
A
I
Y
V
N
R
R
F
H
F
P
I
Y
Y
L
M
A
N
L
A
A
A
D
F
F
A
G
L
A
Y
--
F
Y
L
M
F
N
T
-
G
--
P
N
T
R
R
L
T
V
S
T
W
L
L
R
Q
G
L
I
D
T
S
L
T
A
S
-
V
A
N
L
L
A
I
A
I
E
R
H
I
T
V
-
F
R
M
Q
L
H
T
R
-
M
---
S
N
R
R
V
V
V
V
I
V
V
I
W
T
M
A
I
V
M
G
A
I
P
S
V
-
G
W
N
-
C
I
--
C
-----
D
I
------
E
N
C
S
N
--------
M
-------
A
P
L
Y
S
D
----
S
Y
L
-
V
-
F
W
A
I
F
N
--
L
V
T
F
V
V
M
V
V
L
Y
A
H
I
F
G
Y
V
A
D
L
E
D
N
W
E
T
L
N
------------------------------------------------------------------------------------------------------------------------------------------------------
D
-------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
K
V
I
E
K
A
D
N
A
A
Q
---
V
K
D
A
L
T
K
M
R
A
A
A
L
D
A
Q
K
A
M
K
D
F
R
H
G
F
D
I
L
--
V
G
Q
I
D
D
A
L
K
L
A
--
N
E
G
K
V
K
E
A
Q
A
A
A
E
Q
L
K
T
T
R
N
A
Y
I
Q
K
Y
L
R
N
R
D
T
M
M
S
L
L
K
T
V
V
I
V
L
G
A
F
I
I
C
W
T
P
G
L
V
L
L
L
L
D
V
C
C
P
Q
C
2
PsiBlast_PDB
76.31
100%
-175
- C5 -
4Z35
2
?
A:
[41-250]
----------------------
Q
C
F
Y
N
E
S
I
A
F
F
Y
N
R
S
G
K
H
L
A
T
E
W
N
T
V
S
K
L
V
M
G
L
G
I
T
V
C
I
F
I
M
L
A
N
L
L
V
M
V
A
I
Y
V
N
R
R
F
H
F
P
I
Y
Y
L
M
A
N
L
A
A
A
D
F
F
A
G
L
A
Y
--
F
Y
L
M
F
N
T
-
G
--
P
N
T
R
R
L
T
V
S
T
W
L
L
R
Q
G
L
I
D
T
S
L
T
A
S
-
V
A
N
L
L
A
I
A
I
E
R
H
I
T
V
-
F
R
M
Q
L
H
T
R
-
M
---
S
N
R
R
V
V
V
V
I
V
V
I
W
T
M
A
I
V
M
G
A
I
P
S
V
-
G
W
N
-
C
I
--
C
-----
D
I
------
E
N
C
S
N
--------
M
-------
A
P
L
Y
S
D
----
S
Y
L
-
V
-
F
W
A
I
F
N
--
L
V
T
F
V
V
M
V
V
L
Y
A
H
I
F
G
Y
V
A
D
L
E
D
N
W
E
T
L
N
------------------------------------------------------------------------------------------------------------------------------------------------------
D
-------------------------------------------------------------------------------------------------------------------------------------------------------
N
L
K
V
I
E
K
A
D
N
A
A
Q
---
V
K
D
A
L
T
K
M
R
A
A
A
L
D
A
Q
K
A
M
K
D
F
R
H
G
F
D
I
L
--
V
G
Q
I
D
D
A
L
K
L
A
--
N
E
G
K
V
K
E
A
Q
A
A
A
E
Q
L
K
T
T
R
N
A
Y
I
Q
K
Y
L
R
N
R
D
T
M
M
S
L
L
K
T
V
V
I
V
L
G
A
F
I
I
C
W
T
P
G
L
V
L
L
L
L
D
V
C
C
P
Q
C
7
PsiBlast_PDB
74.71
26%
-166
- C5 -
3REY
1
AA2AR_HUMAN
A:
[7-303]
-------------------------------------------------
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
I
P
F
A
I
T
I
S
T
-
G
--
F
C
A
---
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
-
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
-
V
---
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
-
G
W
N
-
N
C
--
G
-----
Q
P
-----------GCGEGQ--
V
-------
A
C
L
F
E
D
V
V
P
M
N
Y
M
-
V
-
Y
F
N
F
F
A
CV
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
------------------------------------------------------------------------------------------------------------------------------------------------------
L
-------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
--
C
S
H
A
P
L
W
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
------------------------------------
16
PsiBlast_PDB
74.46
25%
-168
- C5 -
3VGA
1
AA2AR_HUMAN
A:
[6-303]
------------------------------------------------
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
I
P
F
A
I
T
I
S
T
-
G
--
F
C
A
---
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
-
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
-
V
---
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
-
G
W
N
--------------------
N
C
G
Q
SQGCGEGQ
V
-------
A
C
L
F
E
D
VVP
M
N
Y
M
-
V
-
Y
F
N
F
F
A
CV
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
------------------------------------------------------------------------------------------------------------------------------------------------------
L
-------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
--
C
S
H
A
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
---------------------------------
8
PsiBlast_PDB
74.28
26%
-166
- C5 -
3RFM
1
AA2AR_HUMAN
A:
[7-303]
-------------------------------------------------
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
I
P
F
A
I
T
I
S
T
-
G
--
F
C
A
---
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
-
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
-
V
---
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
-
G
W
N
-
N
C
--
G
-----
Q
P
-----------GCGEGQ--
V
-------
A
C
L
F
E
D
V
V
P
M
N
Y
M
-
V
-
Y
F
N
F
F
A
CV
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
------------------------------------------------------------------------------------------------------------------------------------------------------
L
-------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
--
C
S
H
A
P
L
W
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
------------------------------------
54
HHSearch
74.19
23%
-156
- C5 -
3EML
13
ENLYS_BPT4
A:
[22-472]
-------------------------------------------------
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
--
I
P
F
A
I
T
I
-
S
--
T
-
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
-
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
-
R
I
P
L
R
Y
N
G
L
V
---
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
-
G
W
N
-
N
C
--
G
-----
Q
S
------
Q
G
C
G
E
--------
G
QVACLFE
D
V
V
P
M
N
----
Y
M
V
Y
F
-
N
F
F
A
C
V
--
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
-------------------------------------------------------------------------------------------------------------------------------------------------------
A
Y
R
S
T
L
Q
K
E
V
H
A
A
---
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
CS
H
A
P
L
W
L
M
Y
L
A
I
--
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
-------------------------------
15
PsiBlast_PDB
74.10
25%
-168
- C5 -
3VG9
8
?
A:
[6-303]
------------------------------------------------
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
I
P
F
A
I
T
I
S
T
-
G
--
F
C
A
---
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
-
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
-
V
---
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
-
G
W
N
--------------------
N
C
G
Q
SQGCGEGQ
V
-------
A
C
L
F
E
D
VVPM
N
Y
M
-
V
-
Y
F
N
F
F
A
CV
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
------------------------------------------------------------------------------------------------------------------------------------------------------
L
-------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
--
C
S
H
A
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
--------------------------------
6
PsiBlast_PDB
73.87
26%
-166
- C5 -
3PWH
1
?
A:
[7-303]
-------------------------------------------------
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
I
P
F
A
I
T
I
S
T
-
G
--
F
C
A
---
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
-
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
-
V
---
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
-
G
W
N
-
N
C
--
G
-----
Q
P
-----------GCGEGQ--
V
-------
A
C
L
F
E
D
VVP
M
N
Y
M
-
V
-
Y
F
N
F
F
A
CV
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
------------------------------------------------------------------------------------------------------------------------------------------------------
L
-------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
--
C
S
H
A
P
L
W
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
------------------------------------
10
PsiBlast_PDB
73.46
26%
-168
- C5 -
3UZC
1
AA2AR_HUMAN
A:
[7-303]
-------------------------------------------------
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
I
P
F
A
I
T
I
S
T
-
G
--
F
C
A
---
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
-
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
-
V
---
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
-
G
W
N
-
N
C
--
G
-----
Q
P
-----------GCGEGQ--
V
-------
A
C
L
F
E
D
V
V
P
M
N
Y
M
-
V
-
Y
F
N
F
F
A
CV
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
------------------------------------------------------------------------------------------------------------------------------------------------------
L
-------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
--
C
S
H
A
P
L
W
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
------------------------------------
9
PsiBlast_PDB
73.46
26%
-168
- C5 -
3UZA
1
AA2AR_HUMAN
A:
[7-303]
-------------------------------------------------
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
I
P
F
A
I
T
I
S
T
-
G
--
F
C
A
---
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
-
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
-
V
---
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
-
G
W
N
-
N
C
--
G
-----
Q
P
-----------GCGEGQ--
V
-------
A
C
L
F
E
D
V
V
P
M
N
Y
M
-
V
-
Y
F
N
F
F
A
CV
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
------------------------------------------------------------------------------------------------------------------------------------------------------
L
-------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
--
C
S
H
A
P
L
W
L
M
Y
L
A
I
V
L
A
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
------------------------------------
58
HHSearch
70.61
25%
-150
- C5 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
---------------------------------------------------
Y
A
L
S
Y
C
A
L
I
L
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
--
M
P
W
V
V
Y
L
-
E
V
T
G
G
V
W
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
-
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
-
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
P
L
L
F
-
G
F
N
-
T
T
--
G
-----
D
P
------
T
V
C
S
I
--------
S
-------
N
P
D
-------
F
V
I
-
Y
-
S
S
V
V
S
F
--
Y
L
P
F
G
V
T
V
L
V
Y
A
R
I
Y
V
V
L
K
Q
R
R
R
K
N
I
F
E
M
------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTW
D
A
Y
G
V
P
L
R
E
K
K
A
T
---
Q
M
V
A
I
V
L
G
A
F
I
V
C
W
L
P
F
F
L
T
H
V
L
N
T
H
C
Q
T
C-
H
V
S
P
E
L
Y
S
A
T
T
--
W
L
G
Y
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
S
C
------------------------------------
14
PsiBlast_PDB
70.30
26%
-159
- C5 -
4UHR
1
AA2AR_HUMAN
A:
[6-303]
------------------------------------------------
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
----
L
A
I
P
F
A
I
-
A
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
-
V
---
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
-
G
W
N
N
C
G
--
Q
-----
P
K
------
E
G
K
A
-GCGEGQ--
V
-------
A
C
L
F
E
D
VVP
M
N
Y
M
-
V
-
Y
F
N
F
F
A
CV
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
P
------------------------------------------------------------------------------------------------------------------------------------------------------
L
-------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
E
R
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
--
C
-
H
A
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
Q
E
P
F
K
A
A
A
A
----------------------
53
HHSearch
69.97
21%
-146
- C5 -
3RZE
5
ENLYS_BPT4 (first)
A:
[9-443]
-------------------------------------------------
M
P
L
V
V
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
--
M
P
M
N
I
L
Y
L
L
--
M
S
K
W
S
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
-
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
-
Q
Q
P
L
R
Y
L
K
Y
R
---
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
I
P
I
L
--
G
W
N
-
H
----R----
R
E
------
D
K
C
E
T
--------
D
-------
F
Y
D
V
-
T
----
W
F
K
-
V
M
T
A
I
I
N
F
--
Y
L
P
T
L
L
M
L
W
F
Y
A
K
I
Y
K
A
V
R
Q
H
C
N
I
F
E
M
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW--
D
A
Y
L
H
M
N
R
E
R
K
A
A
---
K
Q
L
G
F
I
M
A
A
F
I
L
C
W
I
P
Y
F
I
F
F
M
V
I
A
F
C
K
N
--
C
C
N
E
H
L
H
M
F
T
I
--
W
L
G
Y
I
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
L
H
I
------------------------------------
13
PsiBlast_PDB
69.64
26%
-162
- C5 -
4UG2
3
?
A:
[6-303]
------------------------------------------------
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
----
L
A
I
P
F
A
I
-
A
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
-
V
---
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
-
G
W
N
N
C
G
--
Q
-----
P
K
------
E
G
K
A
H
S
Q
GCGEGQ
V
-------
A
C
L
F
E
D
VVP
M
N
Y
M
-
V
-
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
--
C
S
H
A
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
--------------------------------
11
PsiBlast_PDB
69.58
26%
-164
- C5 -
2YDO
3
?
A:
[6-303]
------------------------------------------------
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
----
L
A
I
P
F
A
I
-
A
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
-
V
---
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
-
G
W
N
N
C
G
--
Q
-----
P
K
------
E
G
K
A
H
S
Q
GCGEGQ
V
-------
A
C
L
F
E
D
VVP
M
N
Y
M
-
V
-
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
--
C
S
H
A
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
Q
E
P
F
K
A
A
A
A
E
N
L
Y
F
-----------------
12
PsiBlast_PDB
69.06
26%
-162
- C5 -
2YDV
6
?
A:
[6-303]
------------------------------------------------
S
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
----
L
A
I
P
F
A
I
-
A
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
-
V
---
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
-
G
W
N
N
C
G
--
Q
-----
P
K
------
E
G
K
A
H
S
Q
GCGEGQ
V
-------
A
C
L
F
E
D
VVP
M
N
Y
M
-
V
-
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
--
C
S
H
A
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
Q
E
P
F
K
A
A
A
A
E
N
L
Y
F
Q
----------------
49
HHSearch
67.88
22%
-146
- C5 -
3UON
4
ACM2_HUMAN (first)
A:
[24-457]
-------------------------------------------------
V
F
I
V
L
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
--
M
N
L
Y
T
L
Y
T
V
--
I
G
Y
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
-
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
-
T
K
P
L
T
Y
P
V
K
R
---
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
A
I
L
-
F
W
Q
-
F
I
--
V
GVRTV
E
D
------
G
E
C
Y
I
--------
Q
-------
F
F
S
-
N
A
----
A
V
T
-
F
G
T
A
I
A
A
F
--
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
K
S
R
I
N
I
F
E
M
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW--
D
A
Y
P
P
P
S
R
E
K
K
V
T
---
R
T
I
L
A
I
L
L
A
F
I
I
T
W
A
P
Y
N
V
M
V
L
I
N
T
F
C
A
P
--
C
I
P
N
T
V
W
T
I
G
Y
--
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
-------------------------------------
50
HHSearch
67.65
20%
-145
* C5 *
2RH1
16
ADRB2_HUMAN (first)
A:
[38-477]
----------------------------------------------
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
--
V
P
F
G
A
A
H
-
I
L
-
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
-
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
-
T
S
P
F
K
Y
Q
S
L
L
---
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
-
R
A
TH
Q
-----
E
A
I
N
C
Y
A
E
E
T
C
C
D
--------
F
-------
F
T
--
N
Q
----
A
Y
A
-
I
A
S
S
I
V
S
F
--
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
N
I
F
E
M
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW--
D
A
Y
K
F
C
L
K
E
H
K
A
L
---
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
--
L
I
R
K
E
V
Y
I
L
L
N
--
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
------------------------------------