@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LT4R2_HUMAN: (2016-01-11 )
MAPSHRASQVGFCPTPERPLWRLPPTCRPRRMSVCYRPPGNETLLSWKTSRATGTAFLLLAALLGLPGNGFVVWSLAGWRPARGRPLAATLVLHLALADGAVLLLTPLFVAFLTRQAWPLGQAGCKAVYYVCALSMYASVLLTGLLSLQRCLAVTRPFLAPRLRSPALARRLLLAVWLAALLLAVPAAVYRHLWRDRVCQLCHPSPVHAAAHLSLETLTAFVLPFGLMLGCYSVTLARLRGARWGSGRHGARVGRLVSAIVLAFGLLWAPYHAVNLLQAVAALAPPEGALAKLGGAGQAARAGTTALAFFSSSVNPVLYVFTAGDLLPRAGPRFLTRLFEGSGEARGGGRSREGTMELRTTPQLKVVGQGRGNGDPGGGMEKDGPEWDL
Atome Classification :
(20 SA)
.........10........20........30........40........50....--....60........70........80........90..------..------....100..-.------....110..-..-.-..120.......130.......-------140.......150.......160.---.....------.170.......180.....---..-----190....------...----.-.200..------.------.----.---..210----.----......220........230......------.-----240----------------------.....-----------------------------------------------------------------------------------------------------------------------------------------------------------------.--.-----..250-------------------.-......-..260.......270.......280.......290.......300.......310.-......320.......-------330.......340.......350.......360.......370.......380.......------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAPSHRASQVGFCPTPERPLWRLPPTCRP
R
R
M
S
V
C
Y
RPPGN
E
T
L
L
S
W
KTSRAT
G
T
--
A
F
L
L
L
A
A
L
LGLPGN
G
F
V
V
W
SLAGWRPARGR
P
L
A
A
T
L
V
L
------
H
L
------ALAD
G
A
V
L
L
-
L
------
T
P
L
F
V
A
F
L
T
-
R
Q-A-WPL
G
Q
A
G
C
K
A
V
Y
Y
V
C
A
L
S
M
Y
A
S
-------
V
L
L
T
G
L
L
S
L
Q
R
C
L
A
VTR
P
F
L
APRL---R
S
P
A
L
------
A
R
R
L
L
L
A
V
W
L
A
A
L
L
L
A
V
P
A
---
A
V
-----
Y
--
R
H
L
W
------
R
D
R
----
V
-
C
Q
LCHP------S------P----V---
H
A
A
A
H
----
L
----
S
L
E
T
L
T
A
-
F
V
L
P
F
G
L
M
L
G
C
Y
S
V
T
L
A
R
------
L
-----R------------------------GARWG-----------------------------------------------------------------------------------------------------------------------------------------------------------------S--G-----R
H
G
---------------------
A
-
R
V
G
R
L
V
-
S
A
I
V
L
A
F
G
L
L
W
A
P
Y
H
A
V
N
L
L
Q
A
V
A
ALAPPE
G
A
L
A
KLGGAGQAARAG
T
T
A
L
A
F
F
SSS-VN
P
V
L
Y
V
F
TAGDLLPR-------A
G
P
R
F
L
T
R
L
F
EGSGEARGGGRSREG
T
M
E
LRTTP
Q
L
K
V
V
GQGRGNGDPGGGMEKDGPEWDL------------
40
Fugue
83.61
24%
-139
- C2 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
-----------------------
S
F
K
C
A
L
T
K
T
G
F
---------------
Q
F
Y
Y
L
P
--
A
V
Y
I
L
V
F
I
I
G
F
L
G
N
S
V
A
I
W
M
F
V
F
H
--
M
K
P
W
S
G
I
S
V
Y
M
F
------
N
L
------
A
L
A
D
F
L
Y
V
L
-
T
------
L
P
A
L
I
F
Y
Y
F
-
N
K
-
T
D
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
-------
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
K
S
L
G
R
L
---
K
K
K
N
-------
A
I
C
I
S
V
L
V
W
L
I
V
V
V
A
I
S
P
I
---
L
F
-----
Y
S
-
G
T
G
V
------
R
K
N
----
K
-
T
I
T
C
Y
D
------
T
------
T
SDEY
L
---
R
S
Y
F
I
----
Y
----
S
M
C
T
T
V
A
M
F
C
V
P
L
V
L
I
L
G
C
Y
G
L
I
V
R
A
------
L
-----
I
Y
K
M
K
K
Y
T
C
TVCG
Y
I
Y
N
PEDGDPDN
G
V
N
P
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
D
-----
F
K
D
IVCPLCGVGKDQ
F
E
E
V
EE
P
L
R
R
-
K
S
I
Y
L
V
-
I
I
V
L
T
V
F
A
V
S
Y
I
P
F
H
V
M
K
T
M
N
L
R
A
R
L
D
F
Q
T
P
A
M
C
A
F
N
D
R
V
Y
A
T
Y
Q
V
T
R
G
L
A
S
L
N
S
C
-
V
N
P
I
L
Y
F
L
---------------
A
G
D
T
F
R
R
R
----------------------------------------------------------------
21
HHSearch
83.52
22%
-128
- C2 -
3ODU
6
CXCR4_HUMAN (first)
A:
[38-491]
----------------------------------------
C
F
R
E
E
N
A
N
F
N
K
I
F
L
P
--
T
I
Y
S
I
I
F
L
T
G
I
V
G
N
G
L
V
I
L
V
M
G
Y
Q
K
K
L
R
S
--
M
T
D
K
Y
R
L
------
H
L
------
S
V
A
D
L
L
F
V
I
-
T
------
L
P
F
W
A
V
D
A
V
--
A
-
N
-
W
Y
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
-------
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
N
S
Q
R
P
---
R
K
L
L
A
------
E
K
V
V
Y
V
G
V
W
I
P
A
L
L
L
T
I
P
D
---
F
I
-----
F
--
A
N
V
S
E
A
D---
D
R
Y
----
I
-
C
D
R
F
Y
P
------
N
------
D
----
L
---
W
V
V
V
F
----
Q
----
F
Q
H
I
M
V
G
-
L
I
L
P
G
I
V
I
L
S
C
Y
C
I
I
I
S
K
------
L
-----
S
------------------------
H
S
G
S
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYGS
K
--
G
-----
H
Q
K
---------------------
R
-
K
A
L
K
T
T
-
V
I
L
I
L
A
F
F
A
C
W
L
P
Y
Y
I
G
I
S
I
D
S
F
I
L
L
E
I
I
-
K
Q
G
C
E
F
E
N
T
V
H
K
W
I
S
I
T
E
A
L
A
F
F
H
C
C
-
L
N
P
I
L
Y
A
F
L
G
A
K
F
K
T
S
-------
A
Q
H
A
L
T
S
G
R
P
L
E
V
L
F
Q
--------------------------------------------------------
22
HHSearch
83.37
23%
-141
- C2 -
3UON
4
ACM2_HUMAN (first)
A:
[24-456]
---------------------------------------------------
V
F
I
V
--
L
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
--
V
N
N
Y
F
L
F
------
S
L
------
A
C
A
D
L
I
I
G
V
F
S
------
M
N
L
Y
T
L
Y
T
V
-
I
G
-
Y
-
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
-------
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
---
R
T
T
K
M
------
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
A
---
I
L
-----
F
--
W
Q
F
I
V
GVRTV
E
D
G
----
E
-
C
Y
I
Q
F
F
------
S
----------------
N
A
A
V
----
T
----
F
G
T
A
I
A
A
-
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
------
S
-----
K
------------------------
S
R
I
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYP--
P
--
P
-----
S
R
E
---------------------
K
-
K
V
T
R
T
I
-
L
A
I
L
L
A
F
I
I
T
W
A
P
Y
N
V
M
V
L
I
N
T
F
C
A
P
C
I
-----------
P
N
T
V
W
T
I
G
Y
W
L
C
Y
I
N
S
T
-
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
-------
F
K
H
L
L
M
------------------------------------------------------------------
3
PsiBlast_PDB
81.55
30%
-155
- C2 -
4RWA
2
C562_ECOLX (first)
A:
[135-393]
-----------------------------------------------------------------
V
G
L
L
G
N
V
L
V
M
F
G
I
V
--
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
------
N
L
------
A
L
A
D
A
L
A
T
S
-
T
------
L
P
F
Q
S
A
K
Y
L
-
M
E
-
T
-
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
-------
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
------
A
K
L
I
N
I
C
I
W
V
L
A
S
G
V
G
V
P
I
---
M
V
-----
M
---
A
V
T
------
R
P
R
DG
A
V
V
-
C
M
L
Q
F
P
------
S
------
P
----
S
W
Y
W
D
T
V
T
K
----
I
----
C
V
-
F
L
F
A
-
F
V
V
P
I
L
I
I
T
V
C
Y
G
L
M
L
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
K
E
K
D
R
S
L
---------------------
R
-
R
I
T
R
M
V
-
L
V
V
V
G
A
F
V
V
C
W
A
P
I
H
I
F
V
I
V
W
T
L
V
D
I
D
R
R
D
P
L
V
V
-------
A
A
L
H
L
C
I
A
L
G
Y
A
N
S
S
-
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
-------
F
R
Q
L
C
-------------------------------------------------------------------
2
PsiBlast_PDB
81.22
30%
-152
- C2 -
4N6H
21
OPRD_HUMAN
A:
[138-396]
-----------------------------------------------------------------
V
G
L
L
G
N
V
L
V
M
F
G
I
V
--
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
------
N
L
------
A
L
A
D
A
L
A
T
S
-
T
------
L
P
F
Q
S
A
K
Y
L
-
M
E
-
T
-
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
-------
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
------
A
K
L
I
N
I
C
I
W
V
L
A
S
G
V
G
V
P
I
M
V
M
A
V
-----
T
--
R
P
R
D
------
G
A
V
----
V
-
C
M
L
Q
F
P
------
S
------
P
----
S
W
Y
W
D
T
V
T
K
----
I
----
C
V
-
F
L
F
A
-
F
V
V
P
I
L
I
I
T
V
C
Y
G
L
M
L
L
R
------
L
-----
R
------------------------
S
V
R
L
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
G
S
K
E
K
D
R
S
L
---------------------
R
-
R
I
T
R
M
V
-
L
V
V
V
G
A
F
V
V
C
W
A
P
I
H
I
F
V
I
V
W
T
L
V
D
I
D
R
R
D
P
L
V
V
-------
A
A
L
H
L
C
I
A
L
G
Y
A
N
S
S
-
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
-------
F
R
Q
L
C
R
K
P
C
G
--------------------------------------------------------------
1
PsiBlast_PDB
80.86
29%
-158
- C2 -
4EA3
3
C562_ECOLX (first)
A:
[139-395]
------------------------------------------------------------------
G
L
L
G
N
C
L
V
M
Y
V
I
--
L
R
H
T
K
M
K
T
A
T
N
I
Y
I
F
------
N
L
------
A
L
A
D
T
L
V
L
L
-
T
------
L
P
F
Q
G
T
D
I
L
-
L
G
-
F
-
W
P
F
G
N
A
L
C
K
T
V
I
A
I
D
Y
Y
N
M
F
T
S
-------
T
F
T
L
T
A
M
S
V
D
R
Y
V
A
I
C
H
P
----------
T
S
S
K
------
A
Q
A
V
N
V
A
I
W
A
L
A
S
V
V
G
V
P
V
---
A
I
-----
M
G
S
A
Q
V
E
------
D
E
E
----
I
E
C
L
V
E
I
P
------
T
PQDY
W
G
P
----
V
---
F
A
I
C
I
----
F
--------
L
F
S
-
F
I
V
P
V
L
V
I
S
V
C
Y
S
L
M
I
R
R
------
L
-----
R
------------------------
G
V
R
L
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
G
SREK
D
R
N
L
---------------------
R
-
R
I
T
R
L
V
-
L
V
V
V
A
V
F
V
G
C
W
T
P
V
Q
V
F
V
L
A
Q
G
L
G
V
Q
P
S
S
E
T
A
V
A
I
L
R
F
C
--------
T
A
L
G
Y
V
N
S
C
-
L
N
P
I
L
Y
A
F
L
D
E
N
F
K
A
C
-------
F
R
----------------------------------------------------------------------
32
HHSearch
80.61
21%
-144
* C2 *
3PBL
2
DRD3_HUMAN (first)
A:
[41-470]
-----------------------------------------------------
Y
A
--
L
S
Y
C
A
L
I
L
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
--
T
T
N
Y
L
V
V
------
S
L
------
A
V
A
D
L
L
V
A
T
L
V
------
M
P
W
V
V
Y
L
E
V
T
G
G
-
V
-
W
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
-------
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
------
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
P
L
---
L
F
-----
G
--
F
N
T
T
G-----
D
P
T
----
V
-
C
S
I
S
N
P
-------------------------
D
F
----
V
----
I
Y
S
S
V
V
S
-
F
Y
L
P
F
G
V
T
V
L
V
Y
A
R
I
Y
V
V
------
L
-----
K
------------------------
Q
R
R
R
K
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWDAYG
V
--
P
-----
L
R
E
---------------------
K
-
K
A
T
Q
M
V
-
A
I
V
L
G
A
F
I
V
C
W
L
P
F
F
L
T
H
V
L
N
T
H
C
Q
T
C
H
----------
V
S
P
E
L
Y
S
A
T
T
W
L
G
Y
V
N
S
A
-
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
-------
F
L
K
I
L
S
C
-----------------------------------------------------------------
4
PsiBlast_PDB
80.60
30%
-154
- C2 -
4RWD
6
C562_ECOLX (first)
A:
[135-393]
-----------------------------------------------------------------
V
G
L
L
G
N
V
L
V
M
F
G
I
V
--
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
------
N
L
------
A
L
A
D
A
L
A
T
S
-
T
------
L
P
F
Q
S
A
K
Y
L
-
M
E
-
T
-
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
-------
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
A
K
------
A
K
L
I
N
I
C
I
W
V
L
A
S
G
V
G
V
P
I
---
M
V
-----
M
---
A
V
T
------
R
P
R
DG
A
V
V
-
C
M
L
Q
F
P
------
S
------
P
----
S
W
Y
W
D
T
V
T
K
----
I
----
C
V
-
F
L
F
A
-
F
V
V
P
I
L
I
I
T
V
C
Y
G
L
M
L
L
R
------
L
-----
R
------------------------
S
V
R
L
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
G
S
K
E
K
D
R
S
L
---------------------
R
-
R
I
T
R
M
V
-
L
V
V
V
G
A
F
V
V
C
W
A
P
I
H
I
F
V
I
V
W
T
L
V
D
I
D
R
R
D
P
L
V
V
-------
A
A
L
H
L
C
I
A
L
G
Y
A
N
S
S
-
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
-------
F
R
Q
L
C
-------------------------------------------------------------------
6
PsiBlast_PDB
80.02
24%
-151
- C2 -
5C1M
7
?
A:
[26-287]
-------------------------------------------------------------
I
V
C
V
V
G
L
F
G
N
F
L
V
M
Y
V
I
V
--
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
------
N
L
------
A
L
A
D
A
L
A
T
S
-
T
------
L
P
F
Q
S
V
N
Y
L
-
M
G
-
T
-
W
P
F
G
N
I
L
C
K
I
V
I
S
I
D
Y
Y
N
M
F
T
S
-------
I
F
T
L
C
T
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
R
N
------
A
K
I
V
N
V
C
N
W
I
L
S
S
A
I
G
L
P
V
---
M
F
M
A
T
T
K
Y
--
R
Q
G
S
------
I
D
C
----
T
-
L
T
F
S
H
P
------
T
------
W
----
Y
---
W
E
N
L
L
----
K
----
I
C
V
F
I
F
A
-
F
I
M
P
V
L
I
I
T
V
C
Y
G
L
M
I
L
R
------
L
-----
K
------------------------
S
V
R
M
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--
G
S
K
E
K
D
R
N
L
---------------------
R
-
R
I
T
R
M
V
-
L
V
V
V
A
V
F
I
V
C
W
T
P
I
H
I
Y
V
I
I
K
A
L
I
T
I
--
P
E
T
T
F
Q
T
V
S
W
------
H
F
C
I
A
L
G
Y
T
N
S
C
-
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
-------
F
-----------------------------------------------------------------------
23
HHSearch
79.39
20%
-137
- C2 -
2Z73
5
OPSD_TODPA
A:
[29-335]
---------------------------------------------
V
P
D
A
V
Y
Y
S
L
G
--
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
--
P
A
N
M
F
I
I
------
N
L
------
A
F
S
D
F
T
F
S
L
-
V
N
G
----
F
P
L
M
T
I
S
C
F
-
L
K
-
K
-
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
-------
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
---
M
S
H
R
R
------
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
---
I
F
-----
G
--
W
G
A
Y
T
L
E
G--
V
L
C
----
N
-
C
S
F
D
Y
I
------
S
------
R
----
D
S
--
T
T
R
S
N
----
I
----
L
C
M
F
I
L
G
-
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
------
V
-----
S
------------------------
N
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
-----------------------------------------------------------------------------------------------------------------------------------------------
G
--
A
-----
N
A
E
---------------------
M
-
R
L
A
K
I
S
-
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
A
L
L
A
Q
F
G
P
L
E
W
----------
V
T
P
Y
A
A
Q
L
P
V
M
F
A
K
A
S
A
I
-
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
-------
I
S
Q
T
F
P
W
V
L
T
C
C
Q
F
D
D
K
E
T
E
D
D
K
D
A
E
T
E
I
P
A
G
E
---------------------------------------
26
HHSearch
79.18
20%
-141
- C2 -
3RZE
5
ENLYS_BPT4 (first)
A:
[11-441]
-----------------------------------------------------
L
V
--
V
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
--
V
G
N
L
Y
I
V
------
S
L
------
S
V
A
D
L
I
V
G
A
V
V
------
M
P
M
N
I
L
Y
L
L
-
M
S
-
K
-
W
S
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
-------
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
Y
---
R
T
K
T
R
------
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
I
P
I
---
L
G
-----
W
--
N
H
--R-----
R
E
D
----
K
-
C
E
T
D
F
Y
------
D
------
V
----------
T
W
F
----
K
----
V
M
T
A
I
I
N
-
F
Y
L
P
T
L
L
M
L
W
F
Y
A
K
I
Y
K
A
------
V
-----
R
------------------------
Q
H
C
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYL--
H
--
M
-----
N
R
E
---------------------
R
-
K
A
A
K
Q
L
-
G
F
I
M
A
A
F
I
L
C
W
I
P
Y
F
I
F
F
M
V
I
A
F
C
K
N
C
C
-----------
N
E
H
L
H
M
F
T
I
W
L
G
Y
I
N
S
T
-
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
-------
F
K
R
I
L
H
I
-----------------------------------------------------------------
12
PsiBlast_PDB
79.07
25%
-132
- C2 -
4XEE
4
?
A:
[31-344]
-------------------------------------------------
S
K
V
L
V
T
--
A
I
Y
L
A
L
F
V
V
G
T
V
G
N
S
V
T
L
F
T
L
A
--
R
K
-------
S
T
V
H
Y
------
H
L
------
G
S
L
A
L
S
D
L
L
-
I
L
L
L
A
M
P
V
E
L
Y
N
F
I
W
V
-
H
H
-
P
-
W
A
F
G
D
A
G
C
R
G
Y
Y
F
L
R
D
A
C
T
Y
A
T
-------
A
L
N
V
A
S
L
S
V
E
R
Y
L
A
I
C
H
P
F
K
A
K
T
L
---
M
S
R
S
R
------
T
K
K
F
I
S
A
I
W
L
A
S
A
L
L
A
I
P
M
---
L
F
-----
T
--
M
G
L
-------
Q
N
R
----
S
-
A
D
G
T
H
P
GG
L
V
C
-
T
------
P
----
I
---
V
D
T
A
T
V
K
V
V
I
----
Q
V
N
T
F
M
S
-
F
L
F
P
M
-
L
V
I
S
I
L
N
T
V
I
A
N
K
L
T
V
M
V-------------------------------
P
G
R
V
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
L
-----
R
H
G
---------------------
V
-
L
V
L
R
----
A
V
V
I
A
F
V
V
C
W
L
P
Y
H
V
R
R
L
M
---
F
C
Y
I
S
D
E
Q
W
T
T
F
L
F
D
F
Y
H
Y
F
Y
M
L
T
N
A
L
F
Y
A
S
S
A
-
I
N
P
I
L
Y
N
L
V
S
A
N
F
R
Q
V
-------
F
L
S
T
L
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
L
N
A
A
K
S
E
L
D
K
A
I
G
R
N
T
N
G
------------
25
HHSearch
78.59
18%
-132
- C2 -
2RH1
16
ADRB2_HUMAN (first)
A:
[38-475]
------------------------------------------------
V
W
V
V
G
M
G
--
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
--
V
T
N
Y
F
I
T
------
S
L
------
A
C
A
D
L
V
M
G
L
A
V
------
V
P
F
G
A
A
H
I
L
-
M
K
-
M
-
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
-------
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
------
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
---
I
Q
-----
M
H-
W
Y
R
A
TH
Q
---
E
A
I
----
N
-
C
Y
A
E
E
T
CC----
D
------
F
----
F
---
T
N
Q
A
Y
----
A
----
I
A
S
S
I
V
S
-
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
------
A
-----
K
------------------------
R
Q
L
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYK--
F
--
C
-----
L
K
E
---------------------
H
-
K
A
L
K
T
L
-
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
L
I
-----------
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
-
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
-------
F
Q
E
L
L
C
L
-----------------------------------------------------------------
15
PsiBlast_PDB
78.40
25%
-130
- C2 -
4XES
5
?
A:
[31-344]
-------------------------------------------------
S
K
V
L
V
T
--
A
I
Y
L
A
L
F
V
V
G
T
V
G
N
S
V
T
L
F
T
L
A
--
R
K
K
S
L
Q
S
L
Q
S
T
V
H
Y
------
H
L
------
G
S
L
A
L
S
D
L
L
-
I
L
L
L
AM
P
V
E
L
Y
N
F
I
W
V
-
H
H
-
P
-
W
A
F
G
D
A
G
C
R
G
Y
Y
F
L
R
D
A
C
T
Y
A
T
-------
A
L
N
V
A
S
L
S
V
A
R
Y
L
A
I
C
H
P
F
K
A
K
T
L
---
M
S
R
S
R
------
T
K
K
F
I
S
A
I
W
L
A
S
A
L
L
A
I
P
M
---
L
F
-----
T
--
M
G
L
-------
Q
N
R
----
S
-
A
D
G
T
H
P
GG
L
V
C
-
T
------
P
----
I
---
V
D
T
A
T
V
K
V
V
I
----
Q
V
N
T
F
M
S
-
F
L
F
P
M
-
L
V
I
S
I
L
N
T
V
I
A
N
K
L
T
V
M
V-------------------------------
P
G
R
V
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--
L
-----
R
H
G
---------------------
V
-
L
V
L
R
----
A
V
V
I
A
F
V
V
C
W
L
P
Y
H
V
R
R
L
M
---
F
C
Y
I
S
D
E
Q
W
T
T
F
L
F
D
F
Y
H
Y
F
Y
M
L
T
N
A
L
F
Y
A
S
S
A
-
I
N
P
I
L
Y
N
L
V
S
A
N
F
R
Q
V
-------
F
L
S
T
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
L
N
A
A
K
S
E
L
D
K
A
I
G
R
N
T
N
G
V
------------
17
PsiBlast_PDB
77.88
27%
-133
- C2 -
4BWB
1
NTR1_RAT
A:
[18-315]
-------------------------------------------------
S
K
V
L
V
T
--
A
I
Y
L
A
L
F
V
V
G
T
V
G
N
G
V
T
L
F
T
L
A
-------
Q
S
L
Q
S
R
V
D
Y
------
Y
L
G
S
L
A
L
S
D
L
L
I
L
L
F
A
L
-
P
------
V
D
L
Y
N
F
I
W
V
-
H
H
-
P
-
W
A
F
G
D
A
G
C
K
G
Y
Y
F
L
R
E
A
C
T
Y
A
T
-------
A
L
N
V
V
S
L
S
V
E
L
Y
L
A
I
C
H
P
F
K
A
K
T
L
---
M
S
R
S
R
------
T
K
K
F
I
S
A
I
W
L
A
S
A
L
L
A
I
P
M
---
L
F
-----
T
--
M
G
L
-------
Q
N
L
----
S
-
G
D
G
T
H
P
GGLVC-
T
------
P
----
I
---
V
D
T
A
T
----
L
R
V
V
I
Q
L
N
T
F
M
S
-
F
L
F
P
M
L
V
A
S
I
L
N
T
V
A
A
R
R
------
L
T
V
M
V-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------E
P
G
-----
R
V
Q
---------------------
A
L
R
R
G
V
L
V
L
R
A
V
V
I
A
F
V
V
C
W
L
P
Y
H
V
R
R
L
M
F
V
Y
I
S
---
D
E
Q
W
T
T
A
L
F
D
F
Y
H
Y
F
Y
M
L
S
N
A
L
V
Y
V
S
A
A
-
I
N
P
I
L
Y
N
L
V
S
A
N
F
R
Q
V
-------
F
L
S
T
L
A
C
L
C
---------------------------------------------------------------
20
PsiBlast_PDB
77.44
26%
-131
- C2 -
3ZEV
6
NTR1_RAT
A:
[18-315]
-------------------------------------------------
S
K
V
L
V
T
--
A
I
Y
L
A
L
F
V
V
G
T
V
G
N
S
V
T
L
F
T
L
A
--
R
K
K
---
S
L
Q
S
T
V
D
Y
------
Y
L
------
G
S
L
A
L
S
D
L
L
-
I
L
L
L
A
M
P
V
E
L
Y
N
F
I
W
V
-
H
H
-
P
-
W
A
F
G
D
A
G
C
R
G
Y
Y
F
L
R
D
A
C
T
Y
A
T
-------
A
L
N
V
V
S
L
S
V
E
L
Y
L
A
I
C
H
P
F
K
A
K
T
L
---
M
S
R
S
R
------
T
K
K
F
I
S
A
I
W
L
A
S
A
L
L
A
I
P
M
---
L
F
-----
T
--
M
G
L
-------
Q
N
L
----
S
-
G
D
G
T
H
P
GG
L
V
C
-
T
------
P
----
I
---
V
D
T
A
T
----
L
K
V
V
I
Q
V
N
T
F
M
S
-
F
L
F
P
M
L
V
A
S
I
L
N
T
V
I
A
N
K
------
L
T
V
M
V
H
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------P-
G
-----
R
V
Q
---------------------
A
L
R
R
G
V
L
V
L
R
A
V
V
I
A
F
V
V
C
W
L
P
Y
H
V
R
R
L
M
F
C
Y
I
S
---
D
E
Q
W
T
T
F
L
F
D
F
Y
H
Y
F
Y
M
L
T
N
A
L
V
Y
V
S
A
A
-
I
N
P
I
L
Y
N
L
V
S
A
N
F
R
Q
V
-------
F
L
S
T
L
A
C
-----------------------------------------------------------------
45
Fugue
75.73
15%
-110
- C1 -
4D10
-
CSN3_HUMAN
C:
[3-403]
S
A
L
E
Q
F
V
N
S
V
R
Q
L
S
A
------------
Q
G
Q
M
T
Q
L
C
E
L
I
N
K
S
G
E
L
L
A
K
N
L
S
H
L
D
T
V
LG
A
L
D
V
Q
E
H
S
L
G
V
L
A
V
L
F
V
K
F
S
M
P
S
V
P
D
F
E
T
L
F
S
Q
V
Q
L
F
I
S
TCNGE
H
I
------
R
Y
A
T
D
T
F
A
G
-
L
------
C
H
Q
L
T
N
A
L
V
-
E
R
-
K
-
Q
P
L
--
R
G
I
G
I
L
K
Q
A
I
D
K
M
Q
M
N
T
NQLT
S
I
H
A
D
L
C
Q
L
C
L
L
A
K
C
F
K
P
A
L
P
Y
L
D
V
D
M
---
M
D
I
C
K
E
NGAYD
A
K
H
F
L
C
Y
Y
Y
Y
G
G
M
I
Y
T
G
L
K
---
N
F
-----
E
--
R
A
L
Y
-------------
F
-
Y
E
Q
A
I
T
------
T
------
P
----
A
---
M
A
V
S
H
----
I
----
M
L
E
S
Y
K
K
-
Y
I
L
V
S
L
I
L
L
G
---------------------------------------------
K
V
Q
Q
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
P
--
K
-----
Y
T
S
---------------------
Q
-
I
V
G
R
F
I
-
K
P
L
S
N
A
Y
H
E
L
A
Q
V
Y
S
T
N
N
P
S
E
L
R
N
L
V
N
K
H
S
E
T
F
T
R
D
N
N
M
G
L
V
K
Q
C
L
S
S
L
Y
K
K
N
I
Q
R
-
L
T
K
T
F
L
T
L
S
L
Q
D
M
A
S
R
VQLSG
P
Q
E
A
E
K
Y
V
L
H
M
I
E
D
-
G
E
I
F
A
S
I
N
Q
K
D
G
M
V
S
F
H
D
N
P
E
K
Y
N
N
P
A
M
L
H
N
I
D
Q
E
M
L
K
C
I
E
L
D
E
R
L
K
A
M
D
Q
E
I
T
V
NPQF
30
HHSearch
75.06
18%
-134
- C2 -
3EML
13
ENLYS_BPT4
A:
[22-465]
---------------------------------------------------
S
V
Y
I
--
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
--
V
T
N
Y
F
V
V
------
S
L
------
A
A
A
D
I
A
V
G
V
L
A
------
I
P
F
A
I
T
I
S
---
T
-
G
-
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
-------
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
------
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
---
M
L
-----
G
--
W
N
N
C
GQ-----
S
Q
----
G
-
C
G
E
G
Q
V
ACLFE-
D
------
V
----
V
---
P
M
N
Y
M
----
V
----
Y
F
N
F
F
A
C
-
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
------
A
-----
R
------------------------
R
Q
L
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
R
S
-
T
--
L
-----
Q
K
E
---------------------
V
-
H
A
A
K
S
L
-
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
---------
H
A
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
-
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
-------
F
R
K
I
I
R
S
H
V
L
R
Q
------------------------------------------------------------
39
Fugue
74.01
16%
-112
- C2 -
1F88
8
OPSD_BOVIN
A:
[1-348]
------------
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
--
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
--
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
--
T
P
L
N
Y
I
L
L
------
N
L
------
A
V
A
D
L
F
M
V
F
-
G
------
G
F
T
T
T
L
Y
T
S
-
L
H
G
Y
-
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
-------
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
---
G
E
N
H
A
------
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
---
V
G
-----
W
--
S
R
Y
I
------
P
E
G
----
M
-
Q
C
S
C
G
I
DYYTPH
E
------
E
----
T
---
N
N
E
S
F
----
V
----
I
Y
M
F
V
V
H
-
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
------
V
-----
K
EA----------------------
A
A
S
A
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
Q
-----
K
A
E
---------------------
K
-
E
V
T
R
M
V
-
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
-----------
H
Q
G
S
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
---------------------------------------
N
K
Q
F
R
N
C
-
M
V
T
T
L
C
C
G
K
N
P
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
-------------
29
HHSearch
73.69
19%
-138
- C2 -
2KS9
1
NK1R_HUMAN
A:
[32-320]
--------------------------------------------------
I
V
L
W
A
--
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
--
V
T
N
Y
F
L
V
------
N
L
------
A
F
A
E
A
S
M
A
A
F
N
------
T
V
V
N
F
T
Y
A
V
-
H
N
-
E
-
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
-------
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
-----
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-----------------------