@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : MTR1A_HUMAN: (2016-01-11 )
MQGNGSALPNASQPVLRGDGARPSWLASALACVLIFTIVVDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLMSIFNNGWNLGYLHCQVSGFLMGLSVIGSIFNITGIAINRYCYICHSLKYDKLYSSKNSLCYVLLIWLLTLAAVLPNLRAGTLQYDPRIYSCTFAQSVSSAYTIAVVVFHFLVPMIIVIFCYLRIWILVLQVRQRVKPDRKPKLKPQDFRNFVTMFVVFVLFAICWAPLNFIGLAVASDPASMVPRIPEWLFVASYYMAYFNSCLNAIIYGLLNQNFRKEYRRIIVSLCTARVFFVDSSNDVADRVKWKPSPLMTNNNVVKVDSV
Atome Classification :
(20 SA)
.........10...------.....20..----------.------.....30........--40........50........60........70........80........-90........100.......110.......120.......130......---.140.......150...-....160..-...-..170...--.-------....--------.------180-----..-...-----..190.......200.......210.......220...--------------------------------------------------------------------------------------------------------------------------------------------------------.---------------------------------------------------------------------------------------------------------------------------------------------------------....230-----........240.....-...250....--...260---........270.......280.......290.......300.......310.......320.......330.......340.......350
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MQGNGSALPNASQP------VLRGDGA
R
P
----------
S
------
W
L
A
S
A
L
A
C
V
L
I
F
T
I
V
--
V
D
I
L
G
N
L
L
V
I
L
S
V
Y
RNKKLRNAG
N
I
F
V
V
S
L
A
V
A
D
L
V
V
A
IYP
Y
P
L
V
L
M
S
I
F
-NNGW
N
L
G
Y
L
H
C
Q
V
S
G
F
L
M
G
L
S
V
I
G
S
I
F
N
I
T
G
I
A
IN
R
Y
C
Y
I
C
HSL
K
Y
D
K
L
---YSSKN
S
L
C
Y
V
L
L
I
W
L
L
T
-
L
A
A
V
LPNLR-AG
T
-
L
QY--DP
R
--
I
-------
Y
S
C
T
--------
F
------
A
Q
S-----VS-S
A
Y
-----
T
I
A
V
V
V
F
H
F
L
V
P
M
I
I
V
I
F
C
Y
L
R
I
W
I
L
V
L
Q
V
R
Q
RV-KPD--------------------------------------------------------------------------------------------------------------------------------------------------------R---------------------------------------------------------------------------------------------------------------------------------------------------------KPKL
K
P
------
Q
D
F
R
N
F
V
T
M
-
F
V
V
F
V
L
-
F
A
I
C
W
A
P
L
N
F
--
I
G
L
AV----AS
D
P
A
S
MVPRI
P
E
W
L
F
V
A
S
Y
Y
M
A
Y
F
N
S
C
L
N
A
I
I
Y
G
L
LN
Q
N
F
R
K
E
Y
R
R
I
I
V
S
L
CT
A
R
V
F
F
VDSSND
V
A
D
RVKWKPSPLMTNN
N
V
V
K
VDSV
24
HHSearch
88.29
25%
-148
- C2 -
3RZE
5
ENLYS_BPT4 (first)
A:
[11-443]
---------------------------------------------------
L
V
V
V
L
S
T
I
C
L
--
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
M
P
M
N
I
L
Y
L
L
-
M
S
K
W
S
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
R
Y
L
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
-
F
L
W
V
I
P
I
L
G
-
W
N
H
-------
R
R
--
E
-------
D
K
C
E
--------
T
------
D
F
Y
-----
D
V
-
T
W
F
-----
K
V
M
T
A
I
I
N
F
Y
L
P
T
L
L
M
L
W
F
Y
A
K
I
Y
K
A
V
R
Q
H
C
N
I
F
-
E
M
L
--------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWD--
A
Y
L
H
M
N
------
R
E
R
K
A
A
K
Q
L
-
G
F
I
M
A
A
-
F
I
L
C
W
I
P
Y
F
I
--
F
F
M
V
I
----
A
F
C
K
N
C
----
C
N
E
H
L
H
M
F
T
I
W
L
G
Y
I
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
L
H
I
--------------------------------------
29
HHSearch
87.46
26%
-159
- C2 -
3EML
13
ENLYS_BPT4
A:
[21-472]
------------------------------------------------
S
S
V
Y
I
T
V
E
L
A
I
A
V
--
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
I
P
F
A
I
T
I
S
---
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
-
F
A
I
G
L
T
P
M
L
G
W
N
N
-
C
G
Q
-------
S
QGCGEGQ
V
A
C
L
--------
F
------
E
D
V
-----
V
P
M
N
Y
M
-----
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
N
I
F
-
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
---------------------------------------------------------------------------------------------------------------------------------------------------------
Y
R
S
T
L
Q
------
K
E
V
H
A
A
K
S
L
-
A
I
I
V
G
L
-
F
A
L
C
W
L
P
L
H
I
--
I
N
C
F
T
----
F
F
C
P
D
C
--
S
H
A
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
---------------------------------
23
HHSearch
86.09
23%
-151
- C2 -
3UON
4
ACM2_HUMAN (first)
A:
[25-457]
--------------------------------------------------
F
I
V
L
V
A
G
S
L
S
L
--
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
M
N
L
Y
T
L
Y
T
V
-
I
G
Y
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
---
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
-
F
I
L
W
A
P
A
I
L
-
F
W
Q
F
I
V
G
VR
T
V
E
--
D
-------
G
E
C
Y
--------
I
------
Q
F
F
-----
S
N
-
A
A
V
-----
T
F
G
T
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
K
S
R
I
N
I
F
-
E
M
L
--------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWD--
A
Y
P
P
P
S
------
R
E
K
K
V
T
R
T
I
-
L
A
I
L
L
A
-
F
I
I
T
W
A
P
Y
N
V
--
M
V
L
I
N
----
T
F
C
A
P
----
C
I
P
N
T
V
W
T
I
G
Y
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
---------------------------------------
31
HHSearch
83.71
25%
-162
- C2 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
---------------------------------------------------
Y
A
L
S
Y
C
A
L
I
L
--
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
M
P
W
V
V
Y
L
E
V
T
G
G
V
W
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
-
F
A
V
S
C
P
L
L
F
-
G
F
N
-
T
T
----
G
D
--
P
-------
T
V
C
S
--------
I
------
S
N
P
---------
D
F
-----
V
I
Y
S
S
V
V
S
F
Y
L
P
F
G
V
T
V
L
V
Y
A
R
I
Y
V
V
L
K
Q
R
R
R
K
N
-
I
F
E
--------------------------------------------------------------------------------------------------------------------------------------------------------
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWD
A
Y
G
V
P
L
------
R
E
K
K
A
T
Q
M
V
-
A
I
V
L
G
A
-
F
I
V
C
W
L
P
F
F
L
--
T
H
V
L
N
----
T
H
C
Q
T
C
---
H
V
S
P
E
L
Y
S
A
T
T
W
L
G
Y
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
S
C
--------------------------------------
20
PsiBlast_PDB
83.41
23%
-145
- C2 -
3DQB
8
GNAT1_BOVIN (first)
A:
[2-325]
---
N
G
T
E
G
P
N
F
Y
V
P
FSNKTG
V
V
R
S
P
F
E
A
P
----------
Q
YYLAE
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
--
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-
N
F
R
---
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
-
L
A
C
A
A
P
P
L
--
V
G
W
-
S
R
Y
--
I
P
E
--
G
-------
M
Q
C
S
CGIDYYTP
H
------
E
E
T
-----
N
N
-
E
S
F
-----
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
---
L
V
F
T
V
K
E
A
A
-
A
Q
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
T
T
Q
------
K
A
E
K
E
V
T
R
M
-
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
--
V
A
F
Y
I
F
T
H
Q
G
S
D
F
G
P
I
F
M
T
I
P
A
-------
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
---
N
C
M
V
T
T
L
C
C
G
K
N
--------------------------------
11
PsiBlast_PDB
83.33
26%
-165
- C2 -
4AMJ
12
ADRB1_MELGA
A:
[12-299]
-------------------------------------------------
A
G
M
S
L
L
M
A
L
V
V
L
--
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-
H
W
W
-
R
D
E
--
D
P
Q
--
A
-------
L
K
C
Y
--------
Q
------
D
P
G
CCDFV
T
N
-
R
A
Y
-----
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
---
R
E
A
K
E
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S
R
V
M
L
M
R
E
H
K
A
L
K
T
L
-
G
I
I
M
G
V
-
F
T
L
C
W
L
P
F
F
L
--
V
N
I
V
N
----
V
F
N
R
----
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
---------------------------------------
1
PsiBlast_PDB
83.21
26%
-166
- C2 -
2VT4
8
ADRB1_MELGA
A:
[12-297]
-------------------------------------------------
A
G
M
S
L
L
M
A
L
V
V
L
--
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-
H
W
W
-
R
D
E
--
D
P
Q
--
A
-------
L
K
C
Y
--------
Q
------
D
P
G
CCDFV
T
N
-
R
A
Y
-----
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
---
R
E
A
K
E
Q
I
R----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
K
A
L
K
T
L
-
G
I
I
M
G
V
-
F
T
L
C
W
L
P
F
F
L
--
V
N
I
V
N
----
V
F
N
R
----
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
---------------------------------------
42
Fugue
83.17
22%
-124
- C2 -
1F88
8
OPSD_BOVIN
A:
[1-348]
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
------
N
K
T
G
V
V
R
S
P
FEAPQYYLAE
P
------
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
--
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
----
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
-
L
A
C
A
A
P
P
L
V
--
G
W
-
S
R
Y
--
I
P
E
GM
Q
-------
C
S
C
G
--------
I
DYYTPH
E
E
T
-----
N
N
-
E
S
F
-----
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
-------
T
V
-
K
E
A
--------------------------------------------------------------------------------------------------------------------------------------------------------
A
---------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
A
T
T
Q
------
K
A
E
K
E
V
T
R
M
-
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
--
V
A
F
Y
I
----
F
T
H
Q
G
S
--
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
-
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
-------------------
G
K
N
P
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
4
PsiBlast_PDB
83.07
26%
-166
- C2 -
2YCZ
2
ADRB1_MELGA
A:
[12-297]
-------------------------------------------------
A
G
M
S
L
L
M
A
L
V
V
L
--
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-
H
W
W
-
R
D
E
--
D
P
Q
--
A
-------
L
K
C
Y
--------
Q
------
D
P
G
CCDFV
T
N
-
R
A
Y
-----
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
---
R
E
A
K
E
Q
I
R
K
I
D
--------------------------------------------------------------------------------------------------------------------------------------------------------
R
---------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
K
R
K
R
V
M
L
M
--
R
E
H
K
A
L
K
T
L
-
G
I
I
M
G
V
-
F
T
L
C
W
L
P
F
F
L
--
V
N
I
V
N
----
V
F
N
R
----
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
--------------------------------------
9
PsiBlast_PDB
82.86
26%
-171
- C2 -
2Y03
9
ADRB1_MELGA
A:
[12-299]
-------------------------------------------------
A
G
M
S
L
L
M
A
L
V
V
L
--
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-
H
W
W
-
R
D
E
--
D
P
Q
--
A
-------
L
K
C
Y
--------
Q
------
D
P
G
CCDFV
T
N
-
R
A
Y
-----
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
---
R
E
A
K
E
Q
I
R---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S
R
V
M
L
M
R
E
H
K
A
L
K
T
L
-
G
I
I
M
G
V
-
F
T
L
C
W
L
P
F
F
L
--
V
N
I
V
N
----
V
F
N
R
----
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
---------------------------------------
12
PsiBlast_PDB
82.82
26%
-165
- C2 -
3ZPQ
11
ADRB1_MELGA
A:
[12-299]
-------------------------------------------------
A
G
M
S
L
L
M
A
L
V
V
L
--
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-
H
W
W
-
R
D
E
--
D
P
Q
--
A
-------
L
K
C
Y
--------
Q
------
D
P
G
CCDFV
T
N
-
R
A
Y
-----
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
---
R
E
A
K
E
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S
R
V
M
L
M
R
E
H
K
A
L
K
T
L
-
G
I
I
M
G
V
-
F
T
L
C
W
L
P
F
F
L
--
V
N
I
V
N
----
V
F
N
R
----
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
---------------------------------------
5
PsiBlast_PDB
82.81
26%
-167
- C2 -
2YCY
6
ADRB1_MELGA
A:
[12-297]
-------------------------------------------------
A
G
M
S
L
L
M
A
L
V
V
L
--
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-
H
W
W
-
R
D
E
--
D
P
Q
--
A
-------
L
K
C
Y
--------
Q
------
D
P
G
CCDFV
T
N
-
R
A
Y
-----
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
---
R
E
A
K
E
Q
I
R--
D
--------------------------------------------------------------------------------------------------------------------------------------------------------
R
---------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
K
R
K
R
V
M
L
M
--
R
E
H
K
A
L
K
T
L
-
G
I
I
M
G
V
-
F
T
L
C
W
L
P
F
F
L
--
V
N
I
V
N
----
V
F
N
R
----
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
--------------------------------------
18
PsiBlast_PDB
82.74
23%
-136
- C2 -
3C9L
15
OPSD_BOVIN
A:
[2-325]
---
N
G
T
E
G
P
N
F
Y
V
P
FSNKTG
V
V
R
S
P
F
E
A
P
----------
Q
YYLAE
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
--
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-
N
F
R
---
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
-
L
A
C
A
A
P
P
L
--
V
G
W
-
S
R
Y
--
I
P
E
--
G
-------
M
Q
C
S
CGIDYYTP
H
------
E
E
T
-----
N
N
-
E
S
F
-----
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
---
L
V
F
T
V
K
E
A
A
-
A
Q
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
T
T
Q
------
K
A
E
K
E
V
T
R
M
-
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
--
V
A
F
Y
I
F
T
H
Q
G
S
D
F
G
P
I
F
M
T
I
P
A
-------
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
---
N
C
M
V
T
T
L
C
C
G
K
N
D
D
E
-----------------------------
15
PsiBlast_PDB
82.58
25%
-166
- C2 -
5C1M
7
?
A:
[1-294]
--
G
S
H
S
L
-
P
Q
T
G
S
P
------
S
M
--------------------------
V
T
A
I
T
I
M
A
L
Y
S
I
V
C
V
V
G
L
F
G
N
F
L
V
M
Y
V
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
N
L
A
L
A
D
-
A
L
A
T
S
T
L
P
F
Q
S
V
N
Y
L
-
M
G
T
W
P
F
G
N
I
L
C
K
I
V
I
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
C
T
M
S
V
D
R
Y
I
A
V
C
H
P
V
K
A
L
D
F
---
R
T
P
R
N
A
K
I
V
N
V
C
N
W
I
L
S
-
S
A
I
G
L
P
V
M
F
-
M
A
T
-
T
K
Y
--
R
Q
G
--
S
-------
I
D
C
T
--------
L
------
T
F
S
-----
H
P
-
T
W
Y
W
E
N
L
L
K
I
C
V
F
I
F
A
F
I
M
P
V
L
I
I
T
V
C
Y
---
G
L
M
I
L
R
L
K
S
-
V
-
R
M
L
--------------------------------------------------------------------------------------------------------------------------------------------------------
S
---------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
K
E
K
D
------
R
N
L
R
R
I
T
R
M
V
L
V
V
V
A
V
-
F
I
V
C
W
T
P
I
H
I
Y
V
I
I
K
A
L
----
I
T
I
P
E
T
T
F
Q
T
V
-
S
W
H
F
C
I
A
--
L
G
Y
T
N
S
C
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
--------------------------------------------
17
PsiBlast_PDB
82.57
23%
-149
- C2 -
3CAP
8
OPSD_BOVIN
A:
[2-325]
---
N
G
T
E
G
P
N
F
Y
V
P
FSNKTG
V
V
R
S
P
F
E
A
P
----------
Q
YYLAE
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
--
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-
N
F
R
---
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
-
L
A
C
A
A
P
P
L
--
V
G
W
-
S
R
Y
--
I
P
E
--
G
-------
M
Q
C
S
CGIDYYTP
H
------
E
E
T
-----
N
N
-
E
S
F
-----
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
---
L
V
F
T
V
K
E
A
A
-
A
Q
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
T
T
Q
------
K
A
E
K
E
V
T
R
M
-
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
--
V
A
F
Y
I
F
T
H
Q
G
S
D
F
G
P
I
F
M
T
I
P
A
-------
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
---
N
C
M
V
T
T
L
C
C
G
K
N
--------------------------------
6
PsiBlast_PDB
82.51
26%
-168
- C2 -
2Y00
13
ADRB1_MELGA
A:
[12-299]
-------------------------------------------------
A
G
M
S
L
L
M
A
L
V
V
L
--
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-
H
W
W
-
R
D
E
--
D
P
Q
--
A
-------
L
K
C
Y
--------
Q
------
D
P
G
CCDFV
T
N
-
R
A
Y
-----
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
---
R
E
A
K
E
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S
R
V
M
L
M
R
E
H
K
A
L
K
T
L
-
G
I
I
M
G
V
-
F
T
L
C
W
L
P
F
F
L
--
V
N
I
V
N
----
V
F
N
R
----
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
---------------------------------------
8
PsiBlast_PDB
82.40
26%
-168
- C2 -
2Y02
13
ADRB1_MELGA
A:
[12-299]
-------------------------------------------------
A
G
M
S
L
L
M
A
L
V
V
L
--
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-
H
W
W
-
R
D
E
--
D
P
Q
--
A
-------
L
K
C
Y
--------
Q
------
D
P
G
CCDFV
T
N
-
R
A
Y
-----
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
---
R
E
A
K
E
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S
R
V
M
L
M
R
E
H
K
A
L
K
T
L
-
G
I
I
M
G
V
-
F
T
L
C
W
L
P
F
F
L
--
V
N
I
V
N
----
V
F
N
R
----
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
---------------------------------------
2
PsiBlast_PDB
82.24
26%
-161
- C2 -
2YCW
7
ADRB1_MELGA
A:
[12-297]
-------------------------------------------------
A
G
M
S
L
L
M
A
L
V
V
L
--
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-
H
W
W
-
R
D
E
--
D
P
Q
--
A
-------
L
K
C
Y
--------
Q
------
D
P
G
CCDFV
T
N
-
R
A
Y
-----
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
---
R
E
A
K
E
Q
I
R
K
I
D
--------------------------------------------------------------------------------------------------------------------------------------------------------
R
---------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
K
R
K
R
V
M
L
M
--
R
E
H
K
A
L
K
T
L
-
G
I
I
M
G
V
-
F
T
L
C
W
L
P
F
F
L
--
V
N
I
V
N
----
V
F
N
R
----
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
--------------------------------------
10
PsiBlast_PDB
82.18
26%
-166
- C2 -
2Y04
13
ADRB1_MELGA
A:
[12-299]
-------------------------------------------------
A
G
M
S
L
L
M
A
L
V
V
L
--
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
P
F
G
A
T
L
V
V
-
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
---
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
-
H
W
W
-
R
D
E
--
D
P
Q
--
A
-------
L
K
C
Y
--------
Q
------
D
P
G
CCDFV
T
N
-
R
A
Y
-----
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
---
R
E
A
K
E
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S
R
V
M
L
M
R
E
H
K
A
L
K
T
L
-
G
I
I
M
G
V
-
F
T
L
C
W
L
P
F
F
L
--
V
N
I
V
N
----
V
F
N
R
----
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
-
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
---------------------------------------
19
PsiBlast_PDB
82.17
23%
-142
- C2 -
1F88
8
OPSD_BOVIN
A:
[2-325]
---
N
G
T
E
G
P
N
F
Y
V
P
FSNKTG
V
V
R
S
P
F
E
A
P
----------
Q
YYLAE
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
--
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
-
N
F
R
---
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
-
L
A
C
A
A
P
P
L
--
V
G
W
-
S
R
Y
--
I
P
E
--
G
-------
M
Q
C
S
C
G
I
DYYTP
H
------
E
E
T
-----
N
N
-
E
S
F
-----
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
---
L
V
F
T
V
K
E
A
A
-
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
T
T
Q
------
K
A
E
K
E
V
T
R
M
-
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
--
V
A
F
Y
I
F
T
H
Q
G
S
D
F
G
P
I
F
M
T
I
P
A
-------
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
---
N
C
M
V
T
T
L
C
C
G
K
N
P
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
----------------