@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : NK2R_HUMAN: (2016-01-11 )
MGTCDIVTEANISSGPESNTTGITAFSMPSWQLALWATAYLALVLVAVTGNAIVIWIILAHRRMRTVTNYFIVNLALADLCMAAFNAAFNFVYASHNIWYFGRAFCYFQNLFPITAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAGIWLVALALASPQCFYSTVTMDQGATKCVVAWPEDSGGKTLLLYHLVVIALIYFLPLAVMFVAYSVIGLTLWRRAVPGHQAHGANLRHLQAMKKFVKTMVLVVLTFAICWLPYHLYFILGSFQEDIYCHKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTKEDKLELTPTTSLSTRVNRCHTKETLFMAGDTAPSEATSGEAGRPQDGSGLWFGYGLLAPTKTHVEI
Atome Classification :
(20 SA)
.........10........20..--......30-----.........40........50........60........70........80........90....-....100.......110.......120.......130.......--140.--.-----......150.......160.......170...---.....-180...---...--.190.......200.......210.......220.......230...-------------------------------------------------------------------------------------------------------------------------------------------------------.-----------------...240.......250.......260....-...270.......-----------280.......290.......300....--------...310...------....320.......330.......340.......350.......360.......370.......380.......390......---------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MG
T
C
D
I
V
T
EANISSGPESNT
T
G
I
--
T
A
FSMPS------
W
Q
L
A
L
W
A
T
A
Y
L
A
L
V
L
V
A
VTG
N
A
I
V
I
W
I
I
L
A
H
R
R
M
R
T
V
T
N
Y
F
I
V
N
L
A
L
A
D
L
C
M
A
A
F
N
A
A
F
N
F
V
Y
AS-HN
I
W
Y
F
G
R
A
F
C
Y
F
Q
NL
F
P
I
T
A
M
F
V
S
I
Y
S
M
T
A
IAAD
R
Y
M
A
I
VHPF--QP-R--L-----SAP
S
T
K
A
V
I
A
G
I
W
L
V
A
L
A
LASPQ
C
F
Y
S
-
T
V
TM---DQGA
T
-
K
C
V
V
A
W---PED--SG
G
K
T
L
L
L
Y
H
L
V
V
I
A
L
I
Y
F
L
P
L
A
V
M
F
V
A
Y
S
V
I
G
L
T
L
W
R
R
AVPGHQAH-------------------------------------------------------------------------------------------------------------------------------------------------------G-----------------A
N
L
R
H
L
Q
A
M
K
K
F
V
K
T
M
V
L
V
V
L
T
F
A
I
C
W
L
P
Y
-
H
L
Y
F
I
L
G
SFQE
D
I
-----------
Y
C
H
K
F
I
Q
Q
V
Y
L
A
L
F
W
L
A
M
S
S
T
MY
N
P
I
I
--------
Y
C
C
L
N
H
R
F
R------SG
F
R
L
A
F
R
CCPWVTPTKED
K
L
E
LTPTT
S
L
S
T
R
V
N
RCHTK
E
T
L
F
MAGDTAPSEATSGEAGRPQDGS
G
L
W
F
G
Y
GLLAPTKTHVEI---------------------------------------------------------------------
3
PsiBlast_PDB
94.74
53%
-151
- C3 -
2KSB
1
NK1R_HUMAN
A:
[8-345]
--------
D
S
D
L
S
P
N
I
S
T
N
T
S
E
P
--
N
Q
F
V
Q
P
A
------
W
Q
I
V
L
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
T
V
V
N
F
T
Y
A
V
-
H
N
E
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
--
Q
P
-
R
--
L
-----
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
S
-
T
T
E
T
---
M
P
S
R
V
-
V
C
M
I
E
W
---
P
E
H
--
P
N
K
I
Y
E
K
V
Y
H
I
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
L
W
A
S
E
I
P
G
D
S
S
D
-------------------------------------------------------------------------------------------------------------------------------------------------------
R
-----------------
Y
H
-
E
Q
V
S
A
K
R
K
V
V
K
M
M
I
V
V
V
C
T
F
A
I
C
W
L
P
F
-
H
I
F
F
L
L
P
Y
I
N
P
D
L
-----------
Y
L
K
K
F
I
Q
Q
V
Y
L
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
I
--------
Y
C
C
L
N
D
R
F
R
------
L
G
F
K
H
A
F
R
C
C
P
F
I
S
A
G
D
Y
E
G
L
E
M
K
S
T
R
Y
L
Q
T
Q
G
S
V
Y
K
V
S
R
L
E
T
T
I
S
T
V
V
G
A
-----------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
94.74
53%
-151
- C3 -
2KSA
1
NK1R_HUMAN
A:
[8-345]
--------
D
S
D
L
S
P
N
I
S
T
N
T
S
E
P
--
N
Q
F
V
Q
P
A
------
W
Q
I
V
L
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
T
V
V
N
F
T
Y
A
V
-
H
N
E
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
--
Q
P
-
R
--
L
-----
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
S
-
T
T
E
T
---
M
P
S
R
V
-
V
C
M
I
E
W
---
P
E
H
--
P
N
K
I
Y
E
K
V
Y
H
I
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
L
W
A
S
E
I
P
G
D
S
S
D
-------------------------------------------------------------------------------------------------------------------------------------------------------
R
-----------------
Y
H
-
E
Q
V
S
A
K
R
K
V
V
K
M
M
I
V
V
V
C
T
F
A
I
C
W
L
P
F
-
H
I
F
F
L
L
P
Y
I
N
P
D
L
-----------
Y
L
K
K
F
I
Q
Q
V
Y
L
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
I
--------
Y
C
C
L
N
D
R
F
R
------
L
G
F
K
H
A
F
R
C
C
P
F
I
S
A
G
D
Y
E
G
L
E
M
K
S
T
R
Y
L
Q
T
Q
G
S
V
Y
K
V
S
R
L
E
T
T
I
S
T
V
V
G
A
-----------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
94.74
53%
-151
- C3 -
2KS9
1
NK1R_HUMAN
A:
[8-345]
--------
D
S
D
L
S
P
N
I
S
T
N
T
S
E
P
--
N
Q
F
V
Q
P
A
------
W
Q
I
V
L
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
T
V
V
N
F
T
Y
A
V
-
H
N
E
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
--
Q
P
-
R
--
L
-----
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
S
-
T
T
E
T
---
M
P
S
R
V
-
V
C
M
I
E
W
---
P
E
H
--
P
N
K
I
Y
E
K
V
Y
H
I
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
L
W
A
S
E
I
P
G
D
S
S
D
-------------------------------------------------------------------------------------------------------------------------------------------------------
R
-----------------
Y
H
-
E
Q
V
S
A
K
R
K
V
V
K
M
M
I
V
V
V
C
T
F
A
I
C
W
L
P
F
-
H
I
F
F
L
L
P
Y
I
N
P
D
L
-----------
Y
L
K
K
F
I
Q
Q
V
Y
L
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
I
--------
Y
C
C
L
N
D
R
F
R
------
L
G
F
K
H
A
F
R
C
C
P
F
I
S
A
G
D
Y
E
G
L
E
M
K
S
T
R
Y
L
Q
T
Q
G
S
V
Y
K
V
S
R
L
E
T
T
I
S
T
V
V
G
A
-----------------------------------------------------------------------------------------------------
29
HHSearch
89.47
58%
-179
- C3 -
2KS9
1
NK1R_HUMAN
A:
[30-326]
--------------------------------------
W
Q
I
V
L
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
T
V
V
N
F
T
Y
A
V
-
H
N
E
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
--
Q
P
-
R
--
L
-----
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
S
-
T
T
E
T
---
M
P
S
R
V
-
V
C
M
I
E
W
---
P
E
H
--
P
N
K
I
Y
E
K
V
Y
H
I
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
L
W
A
S
E
I
P
G
D
S
S
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
Y
H
E
Q
V
S
A
K
R
K
V
V
K
M
M
I
V
V
V
C
T
F
A
I
C
W
L
P
F
-
H
I
F
F
L
L
P
Y
I
N
P
D
L
-----------
Y
L
K
K
F
I
Q
Q
V
Y
L
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
I
--------
Y
C
C
L
N
D
R
F
R
------
L
G
F
K
H
A
F
R
C
C
P
F
I
S
A
G
D
Y
E
G
L
E
M
K
S
T
R
Y
L
Q
T
Q
G
S
V
Y
K
V
S
R
L
E
T
T
I
S
T
V
V
G
A
-----------------------------------------------------------------------------------------------------
39
HHSearch
81.95
28%
-177
- C3 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
-------------------------------------------
Y
A
L
S
Y
C
A
L
I
L
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
M
P
W
V
V
Y
L
E
V
T
G
G
V
W
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
--
H
Y
-
Q
--
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
P
L
L
F
G
F
-
N
T
T
-----
G
D
P
T
-
V
C
S
I
S
N
---
P
-----------
D
F
V
I
Y
S
S
V
V
S
F
Y
L
P
F
G
V
T
V
L
V
Y
A
R
I
Y
V
V
L
K
Q
R
R
R
K
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
-----------------
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTW
D
A
Y
G
V
P
L
R
E
K
K
A
T
Q
M
V
A
I
V
L
G
A
F
I
V
C
W
L
P
F
-
F
L
T
H
V
L
N
T
H
C
Q
T
C
-----------
H
---
V
S
P
E
L
Y
S
A
T
T
W
L
G
Y
V
N
S
A
L
N
P
V
I
--------
Y
T
T
F
N
I
E
F
R
------
K
A
F
L
K
I
L
S
C
-----------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
80.76
27%
-161
- C3 -
2RH1
16
ADRB2_HUMAN (first)
A:
[43-477]
-------------------------------------------
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
V
P
F
G
A
A
H
I
L
-
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
--
K
Y
-
Q
SL
L
-----
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
T
---
H
Q
E
A
I
-
N
C
Y
A
E
E
---
T
C
C
--
D
-
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGT--
W
-----------------
D
A
Y
K
F
C
L
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
-
F
I
V
N
I
V
H
V
I
Q
D
N
L
---------------
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
--------
Y
C
-
R
S
P
D
F
R
------
I
A
F
Q
E
L
L
C
L
-----------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
79.96
22%
-168
- C3 -
3RZE
5
ENLYS_BPT4 (first)
A:
[12-443]
--------------------------------------------
V
V
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
M
P
M
N
I
L
Y
L
L
-
M
S
K
W
S
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
Q
P
L
--
R
Y
-
L
KY
R
-----
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
I
P
I
L
G
W
N
-
H
-------
R
R
E
D
-
K
C
E
T
D
F
---
Y
D
V
--------
T
W
F
K
V
M
T
A
I
I
N
F
Y
L
P
T
L
L
M
L
W
F
Y
A
K
I
Y
K
A
V
R
Q
H
C
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
------------------
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW-
D
A
Y
L
H
M
N
R
E
R
K
A
A
K
Q
L
G
F
I
M
A
A
F
I
L
C
W
I
P
Y
-
F
I
F
F
M
V
I
A
F
C
K
N
C
-----------
C
----
N
E
H
L
H
M
F
T
I
W
L
G
Y
I
N
S
T
L
N
P
L
I
--------
Y
P
L
C
N
E
N
F
K
------
K
T
F
K
R
I
L
H
I
-----------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
78.50
25%
-164
- C3 -
3ODU
6
CXCR4_HUMAN (first)
A:
[49-495]
-----------------------------------------
I
F
L
P
T
I
Y
S
I
I
F
L
T
G
I
V
G
N
G
L
V
I
L
V
M
G
Y
Q
K
K
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
-
I
T
L
P
F
W
A
V
D
A
V
--
A
N
W
Y
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
--
N
S
-
Q
R
P
R
-----
K
L
L
A
E
K
V
V
Y
V
G
V
W
I
P
A
L
L
L
T
I
P
D
F
I
F
A
-
N
V
S
E
---
A
D
D
R
Y
-
I
C
D
R
F
Y
---
P
N
D
--
L
---
W
V
V
V
F
Q
F
Q
H
I
M
V
G
L
I
L
P
G
I
V
I
L
S
C
Y
C
I
I
I
S
K
L
S
H
S
G
S
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
-----------------
A
Y
G
S
K
G
H
Q
K
R
K
A
L
K
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
Y
-
Y
I
G
I
S
I
D
S
F
I
L
L
E
I
I
K
Q
G
C
-----
E
F
E
N
T
V
H
K
W
I
S
I
T
E
A
L
A
F
F
H
C
C
L
N
P
I
L
--------
Y
A
F
L
G
A
K
F
K
------
T
S
A
Q
H
A
L
T
S
G
R
P
L
E
V
L
F
Q
--------------------------------------------------------------------------------------------------------------------------------------
54
Fugue
76.10
20%
-124
- C3 -
3ODU
6
CXCR4_HUMAN (first)
A:
[37-502]
--
P
C
F
R
E
E
N
A
N
---------------------------
F
N
K
I
F
L
P
T
I
Y
S
I
I
F
L
T
G
I
V
G
N
G
L
V
I
L
V
M
G
Y
Q
K
K
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
I
-
T
L
P
F
W
A
V
D
A
V
-
A
N
-
W
Y
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
NS
Q
R
-
P
--
R
-----
K
L
L
A
E
K
V
V
Y
V
G
V
W
I
P
A
L
L
L
T
I
P
D
F
I
F
A
-
N
V
S
E
---
A
D
D
R
Y
-
I
C
D
R
F
Y
---
P
N
D
--
L
W
V
V
V
F
Q
F
Q
H
I
M
V
G
---
L
I
L
P
G
I
V
I
L
S
C
Y
C
I
I
I
S
K
L
S
H
S
G
S
N
I
F
E
M
L
-------------------------------------------------------------------------------------------------------------------------------------------------------
R
-----------------
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
--
S
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
-
K
R
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
G
T
W
D
A
Y
G
S
K
G
H
Q
K
R
K
A
L
K
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
Y
Y
I
G
I
S
I
D
S
F
I
L
L
EI
I
K
Q
G
C
E
F
E
N
T
V
H
K
W
I
S
I
T
E
A
L
A
F
FHCC
L
N
P
I
L
Y
AFLGAKFKTS
A
Q
H
A
L
TSGRPLEVLFQ
14
PsiBlast_PDB
75.38
26%
-169
- C3 -
4J4Q
10
GNAT1_BOVIN (first)
A:
[12-326]
---------------
P
F
S
N
K
T
G
V
VR
S
P
F
E
A
P
Q
YYLAE
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
-
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
--
S
N
F
R
--
F
-----
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
-
S
R
Y
I
---
P
E
G
M
Q
C
S
C
G
I
D
Y
YTP
H
E
E
--
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
---
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
--
A
Q
Q
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------
S
-----------------
A
T
T
Q
--
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
D
-----------
F
G
P
I
F
M
T
---
I
P
A
F
F
-
A
K
T
S
A
V
Y
N
P
V
I
--------
Y
I
M
M
N
K
Q
F
R
------
N
C
M
V
T
T
L
-
C
C
-
G
K
N
------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
75.26
26%
-171
- C3 -
3PQR
11
OPSD_BOVIN
A:
[12-326]
---------------
P
F
S
N
K
T
G
V
VR
S
P
F
E
A
P
Q
YYLAE
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
-
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
--
S
N
F
R
--
F
-----
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
-
S
R
Y
I
---
P
E
G
M
Q
C
S
C
G
I
D
Y
YTP
H
E
E
--
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
---
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
--
A
Q
Q
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------
S
-----------------
A
T
T
Q
--
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
D
-----------
F
G
P
I
F
M
T
---
I
P
A
F
F
-
A
K
T
S
A
V
Y
N
P
V
I
--------
Y
I
M
M
N
K
Q
F
R
------
N
C
M
V
T
T
L
-
C
C
-
G
K
N
------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
75.09
26%
-153
- C3 -
1F88
8
OPSD_BOVIN
A:
[12-345]
---------------
P
F
S
N
K
T
G
V
VR
S
P
F
E
A
P
Q
YYLAE
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
-
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
--
S
N
F
R
--
F
-----
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
-
S
R
Y
I
---
P
E
G
M
Q
C
S
C
G
I
D
Y
YTP
H
E
E
--
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
---
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
--
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------
S
-----------------
A
T
T
Q
--
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
D
-----------
F
G
P
I
F
M
T
---
I
P
A
F
F
-
A
K
T
S
A
V
Y
N
P
V
I
--------
Y
I
M
M
N
K
Q
F
R
------
N
C
M
V
T
T
L
-
C
C
-
G
K
N
P
------
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
--------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
74.93
26%
-169
- C3 -
3DQB
8
GNAT1_BOVIN (first)
A:
[12-326]
---------------
P
F
S
N
K
T
G
V
VR
S
P
F
E
A
P
Q
YYLAE
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
-
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
--
S
N
F
R
--
F
-----
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
-
S
R
Y
I
---
P
E
G
M
Q
C
S
C
G
I
D
Y
YTP
H
E
E
--
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
---
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
--
A
Q
Q
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------
S
-----------------
A
T
T
Q
--
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
D
-----------
F
G
P
I
F
M
T
---
I
P
A
F
F
-
A
K
T
S
A
V
Y
N
P
V
I
--------
Y
I
M
M
N
K
Q
F
R
------
N
C
M
V
T
T
L
-
C
C
-
G
K
N
------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
74.83
26%
-171
- C3 -
4PXF
9
OPSD_BOVIN
A:
[12-326]
---------------
P
F
S
N
K
T
G
V
VR
S
P
F
E
A
P
Q
YYLAE
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
-
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
--
S
N
F
R
--
F
-----
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
-
S
R
Y
I
---
P
E
G
M
Q
C
S
C
G
I
D
Y
YTP
H
E
E
--
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
---
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
--
A
Q
Q
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------
S
-----------------
A
T
T
Q
--
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
D
-----------
F
G
P
I
F
M
T
---
I
P
A
F
F
-
A
K
T
S
A
V
Y
N
P
V
I
--------
Y
I
M
M
N
K
Q
F
R
------
N
C
M
V
T
T
L
-
C
C
-
G
K
N
------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
74.77
26%
-172
- C3 -
3CAP
8
OPSD_BOVIN
A:
[12-326]
---------------
P
F
S
N
K
T
G
V
VR
S
P
F
E
A
P
Q
YYLAE
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
-
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
--
S
N
F
R
--
F
-----
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
-
S
R
Y
I
---
P
E
G
M
Q
C
S
C
G
I
D
Y
YTP
H
E
E
--
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
---
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
--
A
Q
Q
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------
S
-----------------
A
T
T
Q
--
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
D
-----------
F
G
P
I
F
M
T
---
I
P
A
F
F
-
A
K
T
S
A
V
Y
N
P
V
I
--------
Y
I
M
M
N
K
Q
F
R
------
N
C
M
V
T
T
L
-
C
C
-
G
K
N
------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
74.76
25%
-167
- C3 -
3EML
13
ENLYS_BPT4
A:
[23-469]
------------------------------------------
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
I
P
F
A
I
T
I
S
---
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
--
R
Y
-
N
G
L
V
-----
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
-
N
N
C
G
Q-----
S
Q
-
G
C
G
E
G
Q
---
V
A
C
LF
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW-
D
-----------------
A
Y
R
S
T
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
-
H
I
I
N
C
F
T
F
F
C
P
D
C
-------------
S
H
A
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
--------
Y
A
Y
R
I
R
E
F
R
------
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
74.60
26%
-170
- C3 -
3PXO
6
OPSD_BOVIN
A:
[12-326]
---------------
P
F
S
N
K
T
G
V
VR
S
P
F
E
A
P
Q
YYLAE
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
-
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
--
S
N
F
R
--
F
-----
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
-
S
R
Y
I
---
P
E
G
M
Q
C
S
C
G
I
D
Y
YTP
H
E
E
--
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
---
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
--
A
Q
Q
Q
E
-------------------------------------------------------------------------------------------------------------------------------------------------------
S
-----------------
A
T
T
Q
--
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
D
-----------
F
G
P
I
F
M
T
---
I
P
A
F
F
-
A
K
T
S
A
V
Y
N
P
V
I
--------
Y
I
M
M
N
K
Q
F
R
------
N
C
M
V
T
T
L
-
C
C
-
G
K
N
------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
73.61
26%
-125
- C3 -
1HZX
15
OPSD_BOVIN
A:
[15-346]
---------------
P
F
S
N
K
T
G
V
VR
S
P
F
E
A
P
Q
YYLAE
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
-
V
F
G
G
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
--
S
N
F
R
--
F
-----
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
-
S
R
Y
I
---
P
E
G
M
Q
C
S
C
G
I
D
Y
YTP
H
E
E
--
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
---
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
--
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
T
Q
--
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
D
-----------
F
G
P
I
F
M
T
---
I
P
A
F
F
-
A
K
T
S
A
V
Y
N
P
V
I
--------
Y
I
M
M
N
K
Q
F
R
------
N
C
M
V
T
T
L
-
C
C
-
G
K
N
P
L
G
D
---
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
--------------------------------------------------------------------------------------------------------------------
30
HHSearch
72.52
22%
-163
- C3 -
3UON
4
ACM2_HUMAN (first)
A:
[26-457]
-------------------------------------------
I
V
L
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
M
N
L
Y
T
L
Y
T
V
-
I
G
Y
W
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
--
T
Y
-
P
VK
R
-----
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
A
I
L
F
W
-
Q
F
I
V
GVR
T
V
E
D
G
-
E
C
Y
I
Q
F
---
F
S
--------
N
A
A
V
T
F
G
T
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
K
S
R
I
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
------------------
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW-
D
A
Y
P
P
P
S
R
E
K
K
V
T
R
T
I
L
A
I
L
L
A
F
I
I
T
W
A
P
Y
-
N
V
M
V
L
I
N
T
F
C
A
P
C
-----------
I
----
P
N
T
V
W
T
I
G
Y
W
L
C
Y
I
N
S
T
I
N
P
A
C
--------
Y
A
L
C
N
A
T
F
K
------
K
T
F
K
H
L
L
M
------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
72.42
26%
-121
- C3 -
3OAX
18
OPSD_BOVIN
A:
[15-346]
---------------
P
F
S
N
K
T
G
V
VR
S
P
F
E
A
P
Q
YYLAE
P
W
Q
F
S
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-------------------------------------------------------------------------------------------------------------------------------------------------------
S
-----------------
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-----------
F
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