@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : O11L1_HUMAN: (2016-01-11 )
MEPQNTSTVTNFQLLGFQNLLEWQALLFVIFLLIYCLTIIGNVVIITVVSQGLRLHSPMYMFLQHLSFLEVWYTSTTVPLLLANLLSWGQAISFSACMAQLYFFVFLGATECFLLAFMAYDRYLAICSPLRYPFLMHRGLCARLVVVSWCTGVSTGFLPSLMISRLDFCGRNQINHFFCDLPPLMQLSCSRVYITEVTIFILSIAVLCICFFLTLGPYVFIVSSILRIPSTSGRRKTFSTCGSHLAVVTLYYGTMISMYVCPSPHLLPEINKIISVFYTVVTPLLNPVIYSLRNKDFKEAVRKVMRRKCGILWSTSKRKFLY
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70......-..----80........90........100.......110.......120.......130.......140.......150.......160---------.....---...170.......180.......-----------190.......200.....-..210.......220.....---------..230--------------------..---.----------....240.......250..--.....-260-----......---...270.......280.---------------......290.......300.......310.......320
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MEPQNTS
T
V
T
N
F
Q
L
L
G
F
Q
N
L
L
E
W
Q
A
L
L
F
V
I
F
L
L
I
Y
C
L
T
I
IG
N
V
V
I
I
T
V
V
SQGLRLHS
P
M
Y
M
F
L
Q
H
L
S
F
L
E
V
W
YTST
T
-
V
P
----
L
L
L
A
N
L
L
S
WGQAI
S
F
S
A
C
M
A
Q
L
Y
F
F
V
F
LG
A
T
E
C
F
L
L
A
F
M
A
Y
D
R
Y
L
A
I
C
SPLR
Y
P
F
L
M
H
R
G
L
C
A
R
L
V
V
V
S
W
CTGVST
G
F
L
P
S
L
----------
M
I
S
R
L
---
D
FCGRNQ
I
N
H
F
FCDLP
P
L
M
Q
LSC-----------S
R
V
Y
I
T
E
V
T
I
F
I
L
S
I
A
V
L
-
C
I
C
F
F
L
TL
G
P
Y
V
F
I
V
S
S
I
L
R---------IPSTS--------------------GR---R----------
K
T
F
S
T
CG
S
H
L
A
V
V
T
L
Y
YG
T
--
M
I
S
M
Y
-V-------CPS
P
H
L
---
L
P
E
I
N
K
I
I
S
V
F
Y
T
V
V
T
P
---------------
L
L
N
P
V
I
Y
S
LRNK
D
F
K
E
A
V
R
K
V
M
R
R
KCG
I
L
WSTSKRKFLY
16
PsiBlast_PDB
90.03
22%
-168
- C2 -
3RFM
1
AA2AR_HUMAN
A:
[14-304]
-------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
----
F
A
I
T
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
----------
G
W
N
N
C
GQP-
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
------------------
Y
M
V
Y
F
N
F
F
----
A
C
V
-
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
E
R
--------------------
A
R
S
T
L
Q
----------
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
--
W
L
P
L
H
-
I
I
N
C
F
T
F
F
C
P
D
C
S
H
---
A
P
L
W
L
M
Y
L
A
I
V
L
A
H
T
N
S
---------------
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
---------------
18
PsiBlast_PDB
90.01
22%
-167
- C2 -
3UZC
1
AA2AR_HUMAN
A:
[14-304]
-------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
----
F
A
I
T
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
----------
G
W
N
N
C
GQP-
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
------------------
Y
M
V
Y
F
N
F
F
----
A
C
V
-
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
E
R
--------------------
A
R
S
T
L
Q
----------
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
--
W
L
P
L
H
-
I
I
N
C
F
T
F
F
C
P
D
C
S
H
---
A
P
L
W
L
M
Y
L
A
I
V
L
A
H
T
N
S
---------------
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
---------------
17
PsiBlast_PDB
89.80
22%
-166
- C2 -
3UZA
1
AA2AR_HUMAN
A:
[14-304]
-------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
----
F
A
I
T
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
----------
G
W
N
N
C
GQP-
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
------------------
Y
M
V
Y
F
N
F
F
----
A
C
V
-
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
E
R
--------------------
A
R
S
T
L
Q
----------
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
--
W
L
P
L
H
-
I
I
N
C
F
T
F
F
C
P
D
C
S
H
---
A
P
L
W
L
M
Y
L
A
I
V
L
A
H
T
N
S
---------------
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
---------------
15
PsiBlast_PDB
89.43
22%
-169
- C2 -
3REY
1
AA2AR_HUMAN
A:
[14-304]
-------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
----
F
A
I
T
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
----------
G
W
N
N
C
GQP-
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
------------------
Y
M
V
Y
F
N
F
F
----
A
C
V
-
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
E
R
--------------------
A
R
S
T
L
Q
----------
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
--
W
L
P
L
H
-
I
I
N
C
F
T
F
F
C
P
D
C
S
H
---
A
P
L
W
L
M
Y
L
A
I
V
L
A
H
T
N
S
---------------
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
---------------
14
PsiBlast_PDB
88.98
22%
-166
- C2 -
3PWH
1
?
A:
[14-304]
-------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
----
F
A
I
T
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
----------
G
W
N
N
C
GQP-
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
------------------
Y
M
V
Y
F
N
F
F
----
A
C
V
-
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
E
R
--------------------
A
R
S
T
L
Q
----------
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
--
W
L
P
L
H
-
I
I
N
C
F
T
F
F
C
P
D
C
S
H
---
A
P
L
W
L
M
Y
L
A
I
V
L
A
H
T
N
S
---------------
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
---------------
20
PsiBlast_PDB
87.58
22%
-161
- C2 -
2YDO
3
?
A:
[14-304]
-------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
V
L
A
-
I
P
----
F
A
I
A
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
GWNNCGQPK
E
G
K
A
H
S
---
Q
G
C
G
E
G
Q
V
A
C
L
F
E
D
V
V
P
M
N
------------------
Y
M
V
Y
F
N
F
F
----
A
C
V
-
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S-----------------------------T
L
-
Q
----------
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
--
W
L
P
L
H
-
I
I
N
C
F
T
F
F
C
P
D
C
S
H
---
A
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
---------------
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
Q
E
P
F
K
A
A
A
A
E
13
PsiBlast_PDB
85.08
23%
-160
- C2 -
3ZPR
11
ADRB1_MELGA
A:
[9-299]
---------------------
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
----
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
----------
M
----------------
H
W
W
R
D
E
D
P
-
Q
A
L
K
C
Y
Q
DPGCCDFVT
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
--
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
-------------------------------------------M
L
M
R
E
H
----
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
-
N
-------
V
F
N
R
D
L
---
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
---------------
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
-----------------
10
PsiBlast_PDB
84.71
23%
-158
- C2 -
2Y04
13
ADRB1_MELGA
A:
[9-299]
---------------------
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
----
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
----------
M
----------------
H
W
W
R
D
E
D
P
-
Q
A
L
K
C
Y
Q
DPGCCDFVT
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
--
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
-------------------------------------------S
R
V
M
L
M
R
E
H
-
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
-
N
-------
V
F
N
R
D
L
---
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
---------------
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
----------------
6
PsiBlast_PDB
84.40
23%
-160
- C2 -
2Y00
13
ADRB1_MELGA
A:
[9-299]
---------------------
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
----
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
----------
M
----------------
H
W
W
R
D
E
D
P
-
Q
A
L
K
C
Y
Q
DPGCCDFVT
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
--
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
-------------------------------------------S
R
V
M
L
M
R
E
H
-
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
-
N
-------
V
F
N
R
D
L
---
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
---------------
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
----------------
8
PsiBlast_PDB
84.34
23%
-160
- C2 -
2Y02
13
ADRB1_MELGA
A:
[9-299]
---------------------
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
----
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
----------
M
----------------
H
W
W
R
D
E
D
P
-
Q
A
L
K
C
Y
Q
DPGCCDFVT
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
--
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
-------------------------------------------S
R
V
M
L
M
R
E
H
-
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
-
N
-------
V
F
N
R
D
L
---
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
---------------
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
----------------
11
PsiBlast_PDB
84.21
23%
-157
- C2 -
4AMJ
12
ADRB1_MELGA
A:
[9-299]
---------------------
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
----
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
----------
M
----------------
H
W
W
R
D
E
D
P
-
Q
A
L
K
C
Y
Q
DPGCCDFVT
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
--
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
-------------------------------------------S
R
V
M
L
M
R
E
H
-
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
-
N
-------
V
F
N
R
D
L
---
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
---------------
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
----------------
12
PsiBlast_PDB
84.15
23%
-157
- C2 -
3ZPQ
11
ADRB1_MELGA
A:
[9-299]
---------------------
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
----
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
----------
M
----------------
H
W
W
R
D
E
D
P
-
Q
A
L
K
C
Y
Q
DPGCCDFVT
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
--
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
-------------------------------------------S
R
V
M
L
M
R
E
H
-
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
-
N
-------
V
F
N
R
D
L
---
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
---------------
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
----------------
7
PsiBlast_PDB
84.01
23%
-158
- C2 -
2Y01
12
ADRB1_MELGA
A:
[9-299]
---------------------
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
----
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
----------
M
----------------
H
W
W
R
D
E
D
P
-
Q
A
L
K
C
Y
Q
D
PGCCDFVT
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
--
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
-------------------------------------------S
R
V
M
L
M
R
E
H
-
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
-
N
-------
V
F
N
R
D
L
---
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
---------------
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
----------------
9
PsiBlast_PDB
83.63
23%
-157
- C2 -
2Y03
9
ADRB1_MELGA
A:
[9-299]
---------------------
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
----
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
----------
M
----------------
H
W
W
R
D
E
D
P
-
Q
A
L
K
C
Y
Q
DPGCCDFVT
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
--
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
-----------------------------------------S
R
V
M
L
M
R
E
H
-
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
-
N
-------
V
F
N
R
D
L
---
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
---------------
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
----------------
19
PsiBlast_PDB
83.31
23%
-157
- C2 -
4BVN
11
ADRB1_MELGA
A:
[9-299]
---------------------
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
----
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
V
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
----------
M
----------------
H
W
W
R
D
E
D
P
-
Q
A
L
K
C
Y
Q
DPGCCDFVT
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
--
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
-----------------------------------
K
R
---
K
TS
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
-
N
-------
V
F
N
R
D
L
---
V
P
K
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
---------------
A
M
N
P
I
I
L
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
----------------
3
PsiBlast_PDB
83.22
25%
-148
- C2 -
2YCX
3
ADRB1_MELGA
A:
[9-294]
---------------------
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
----
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
----------
M
----------------
H
W
W
R
D
E
D
P
-
Q
A
L
K
C
Y
Q
DPGCCDFVT
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
--
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
K
---------
I
D
R
A
S
---------------------
K
---
R
----------
K
R
V
M
L
M
R
E
H
K
A
L
K
T
L
--
G
I
--
I
M
G
V
F
T
L
-------
C
W
L
P
F
F
---
L
--
V
N
-
I
V
N
V
F
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
--------------------
4
PsiBlast_PDB
82.90
25%
-155
- C2 -
2YCZ
2
ADRB1_MELGA
A:
[9-297]
---------------------
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
----
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
----------
M
----------------
H
W
W
R
D
E
D
P
-
Q
A
L
K
C
Y
Q
DPGCCDFVT
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
--
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
K
---------
I
D
R
A
S
---------------------
K
---
R
----------
K
R
V
M
L
M
R
E
H
K
A
L
K
T
L
--
G
I
--
I
M
G
V
F
T
L
-------
C
W
L
P
F
F
---
L
--
V
N
-
I
V
N
V
F
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
---------------
2
PsiBlast_PDB
82.86
25%
-154
- C2 -
2YCW
7
ADRB1_MELGA
A:
[9-297]
---------------------
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
----
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
----------
M
----------------
H
W
W
R
D
E
D
P
-
Q
A
L
K
C
Y
Q
D
P
GCCDFVT
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
--
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
K
---------
I
D
R
A
S
---------------------
K
---
R
----------
K
R
V
M
L
M
R
E
H
K
A
L
K
T
L
--
G
I
--
I
M
G
V
F
T
L
-------
C
W
L
P
F
F
---
L
--
V
N
-
I
V
N
V
F
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
---------------
5
PsiBlast_PDB
81.52
25%
-152
- C2 -
2YCY
6
ADRB1_MELGA
A:
[10-297]
----------------------
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
----
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
----------
M
----------------
H
W
W
R
D
E
D
P
-
Q
A
L
K
C
Y
Q
DPGCCDFVT
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
--
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
-----------
D
R
A
S
---------------------
K
---
R
----------
K
R
V
M
L
M
R
E
H
K
A
L
K
T
L
--
G
I
--
I
M
G
V
F
T
L
-------
C
W
L
P
F
F
---
L
--
V
N
-
I
V
N
V
F
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
---------------
34
HHSearch
81.22
16%
-158
- C2 -
2Z73
5
OPSD_TODPA
A:
[32-334]
---------------------
A
V
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
----
L
M
T
I
S
C
F
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
----------
G
W
G
A
Y
---
T
L
E
----
G
V
L
C
N
C
S
F
D
Y
I
S
----------------
R
D
S
T
T
R
S
N
I
L
C
M
F
I
-
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
---------
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
E
---
M
----------
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
--
Y
A
V
V
A
-
L
-------
L
A
Q
F
G
P
LEW
V
T
P
Y
A
A
Q
L
P
V
M
F
A
K
A
S
A
---------------
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
Q
F
D
D
K
E
T
E
D
D