@TOME V2.3
(Nov 2016)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : O51A7_HUMAN: (2016-01-12 )
MSVLNNSEVKLFLLIGIPGLEHAHIWFSIPICLMYLLAIMGNCTILFIIKTEPSLHEPMYYFLAMLAVSDMGLSLSSLPTMLRVFLFNAMGISPNACFAQEFFIHGFTVMESSVLLIMSLDRFLAIHNPLRYSSILTSNRVAKMGLILAIRSILLVIPFPFTLRRLKYCQKNLLSHSYCLHQDTMKLACSDNKTNVIYGFFIALCTMLDLALIVLSYVLILKTILSIASLAERLKALNTCVSHICAVLTFYVPIITLAAMHHFAKHKSPLVVILIADMFLLVPPLMNPIVYCVKTRQIWEKILGKLLNVCGR
Atome Classification :
(20 SA)
.........10........20------------........-------------.30.......---.40....------....50........60---------........70......-..80........90------.........100.......110-------.......120.......130.......140....--...150.......160.......170.......180.......190------....-....-.-------200..-.....210.......220....-...-----------------------------------------------------------------------------------------------------------------------------------------------------------------230-----------------------------------------------------------------------------------------------------------------------------------------------------------------.----...---------.....240.......250........260...-.----------...270.......280.......290.......300.......310---------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSVLNNS
E
V
K
L
F
L
L
IGIPGL-------------E
H
A
H
I
W
F
S
-------------
I
P
I
C
L
M
Y
L
L
A
---
I
MGN
C
T
I
------
L
F
I
IKTEPSLH
E
P
M
Y
Y
---------
F
L
A
M
L
A
V
S
DMGL
S
L
S
S
-
L
P
T
M
L
R
V
F
L
F
NAM-------GISP
N
A
C
F
A
Q
E
F
F
I
H
G
F
T
VMES-------S
V
L
L
I
M
S
L
D
R
F
L
A
I
HNP
L
R
Y
S
S
I
LTSN
R
V
A
K
M
G
L
--
I
L
A
I
R
S
I
L
LVIPF
P
F
T
L
R
R
L
K
Y
C
Q
K
N
L
L
SH
S
Y
CLHQD
T
M
K
L
ACS--------DNKT-N
V
I
Y
-
G
-------
F
F
I
A
L
-
C
T
M
L
D
L
A
L
I
V
L
S
Y
V
L
I
L
K
T
I
L
S
-
I
A
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
----
E
R
L
---------
K
A
L
N
T
C
V
S
H
I
C
A
V
L
T
F
-
Y
V
P
I
I
T
L
A
A
M
H
H
F
A
K-H----------KS
P
L
V
V
I
L
I
A
D
M
F
L
LV
P
P
L
M
N
P
I
V
Y
C
V
K
T
R
Q
I
W
E
K
I
L
G
K
L
L
N
VCGR---------------
23
HHSearch
85.20
19%
-152
- C4 -
2RH1
16
ADRB2_HUMAN (first)
A:
[43-477]
---------------------------------------
M
G
-------------
I
V
M
S
L
I
V
L
A
I
---
V
F
G
N
V
L
V
------
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
---------
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
K
M
W
-------
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
-------
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
--
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
-
W
Y
R
A
T
H
---
Q
E
A
I
N
C
Y
A
E
----
E
T
C
C
--------
D
F
F
T
-
N
Q
A
Y
-
A
-------
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
-
Q
L
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFC--
L
----
K
E
H
---------
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
-
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
-
N
----------
L
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
-------------------
24
HHSearch
84.73
17%
-161
- C4 -
3EML
13
ENLYS_BPT4
A:
[23-470]
--------------------------------------
V
Y
I
-------------
T
V
E
L
A
I
A
V
L
A
---
I
L
G
N
V
L
V
------
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
---------
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
--
G
F
-------
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
-------
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
--
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
G
Q
-------
S
Q
G
C
G
E
G
Q
---
V
A
C
L
--------
F
E
D
V
V
P
M
N
Y
M
V
-------
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
-
Q
L
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
R
S
T
L
-
Q
----
K
E
V
---------
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
-
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
-
D
CS--------
H
A
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
---------------
21
HHSearch
82.11
19%
-148
- C4 -
3UON
4
ACM2_HUMAN (first)
A:
[25-457]
--------------------------------------
F
I
V
-------------
L
V
A
G
S
L
S
L
V
T
---
I
I
G
N
I
L
V
------
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
---------
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
-
M
N
L
Y
T
L
Y
T
V
I
G
Y
W
-------
P
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
-------
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
R
T
T
K
M
A
G
M
M
I
A
--
A
A
W
V
L
S
F
I
L
W
A
P
A
I
L
F
W
Q
F
I
V
G
V
--
R
T
V
E
D
G
E
C
Y
I
Q
F
-----------------
F
S
-
N
A
A
V
-
T
-------
F
G
T
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
K
S
-
R
I
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYPP
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
----
R
E
K
---------
K
V
T
R
T
I
L
A
I
L
L
A
F
I
I
T
-
W
A
P
Y
N
V
M
V
L
I
N
T
F
C
A
-
P
----------
C
I
P
N
T
V
W
T
I
G
Y
W
L
C
Y
I
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
--------------------
17
PsiBlast_PDB
81.01
23%
-161
- C4 -
3ZPQ
11
ADRB1_MELGA
A:
[15-286]
----------------------------------------
S
-------------
L
L
M
A
L
V
V
L
L
I
---
V
A
G
N
V
L
V
------
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
---------
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
-------
F
G
A
T
-------
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
-
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
------
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
---
G
C
C
--------
D
F
V
T
-
N
R
A
Y
-
A
I
A
S
S
I
I
S
F
Y
I
P
L
-
L
I
M
I
F
V
A
L
R
V
--
Y
R
E
A
K
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S
R
V
M
L
M
R
E
H
K
A
L
K
T
-
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
-
D
----------
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
---------------------
14
PsiBlast_PDB
80.79
23%
-166
- C4 -
2Y03
9
ADRB1_MELGA
A:
[15-286]
----------------------------------------
S
-------------
L
L
M
A
L
V
V
L
L
I
---
V
A
G
N
V
L
V
------
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
---------
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
-------
F
G
A
T
-------
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
-
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
------
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
---
G
C
C
--------
D
F
V
T
-
N
R
A
Y
-
A
I
A
S
S
I
I
S
F
Y
I
P
L
-
L
I
M
I
F
V
A
L
R
V
--
Y
R
E
A
K
E
Q
I
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S
R
V
M
L
M
R
E
H
K
A
L
K
T
-
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
-
D
----------
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
---------------------
12
PsiBlast_PDB
80.74
23%
-160
- C4 -
2Y01
12
ADRB1_MELGA
A:
[15-286]
----------------------------------------
S
-------------
L
L
M
A
L
V
V
L
L
I
---
V
A
G
N
V
L
V
------
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
---------
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
-------
F
G
A
T
-------
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
-
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
------
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
---
G
C
C
--------
D
F
V
T
-
N
R
A
Y
-
A
I
A
S
S
I
I
S
F
Y
I
P
L
-
L
I
M
I
F
V
A
L
R
V
--
Y
R
E
A
K
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S
R
V
M
L
M
R
E
H
K
A
L
K
T
-
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
-
D
----------
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
---------------------
26
HHSearch
80.73
18%
-149
- C4 -
3ODU
6
CXCR4_HUMAN (first)
A:
[49-496]
-------------------------------------
I
F
L
P
-------------
T
I
Y
S
I
I
F
L
T
G
---
I
V
G
N
G
L
V
------
I
L
V
M
G
Y
Q
K
K
L
R
S
M
T
D
K
---------
Y
R
L
H
L
S
V
A
D
L
L
F
V
-
I
T
-
L
P
F
W
A
V
D
A
V
-
A
N
W
-------
Y
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
-------
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
A
T
N
S
Q
R
P
R
K
L
L
A
E
K
V
V
Y
V
--
G
V
W
I
P
A
L
L
L
T
I
P
D
F
I
F
A
N
V
S
E
-----
A
D
D
R
Y
I
C
D
R
F
Y
P
N
--------------
D
L
W
-
V
V
V
F
-
Q
-------
F
Q
H
I
M
V
G
L
I
L
P
G
I
V
I
L
S
C
Y
C
I
I
I
S
K
L
S
H
-
S
G
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYGSK
G
H
----
Q
K
R
---------
K
A
L
K
T
T
V
I
L
I
L
A
F
F
A
C
-
W
L
P
Y
Y
I
G
I
S
I
D
S
F
I
L
-
L
EI
I
K
Q
G
C
E
F
E
N
T
V
H
K
W
I
S
I
T
E
A
L
A
F
F
H
C
C
L
N
P
I
L
Y
A
F
L
G
A
K
F
K
T
S
A
Q
H
A
L
T
S
G
R
P
L
---------------
11
PsiBlast_PDB
80.71
23%
-163
- C4 -
2Y00
13
ADRB1_MELGA
A:
[15-286]
----------------------------------------
S
-------------
L
L
M
A
L
V
V
L
L
I
---
V
A
G
N
V
L
V
------
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
---------
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
-------
F
G
A
T
-------
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
-
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
------
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
---
G
C
C
--------
D
F
V
T
-
N
R
A
Y
-
A
I
A
S
S
I
I
S
F
Y
I
P
L
-
L
I
M
I
F
V
A
L
R
V
--
Y
R
E
A
K
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S
R
V
M
L
M
R
E
H
K
A
L
K
T
-
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
-
D
----------
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
---------------------
18
PsiBlast_PDB
80.29
23%
-163
- C4 -
3ZPR
11
ADRB1_MELGA
A:
[15-286]
----------------------------------------
S
-------------
L
L
M
A
L
V
V
L
L
I
---
V
A
G
N
V
L
V
------
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
---------
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
-------
F
G
A
T
-------
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
-
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
------
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
---
G
C
C
--------
D
F
V
T
-
N
R
A
Y
-
A
I
A
S
S
I
I
S
F
Y
I
P
L
-
L
I
M
I
F
V
A
L
R
V
--
Y
R
E
A
K
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------M
L
M
R
E
H
---
K
A
L
K
T
-
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
-
D
----------
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
F
R
K
A
F
K
R
L
L
----------------------
13
PsiBlast_PDB
79.94
23%
-164
- C4 -
2Y02
13
ADRB1_MELGA
A:
[15-286]
----------------------------------------
S
-------------
L
L
M
A
L
V
V
L
L
I
---
V
A
G
N
V
L
V
------
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
---------
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
-------
F
G
A
T
-------
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
-
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
------
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
---
G
C
C
--------
D
F
V
T
-
N
R
A
Y
-
A
I
A
S
S
I
I
S
F
Y
I
P
L
-
L
I
M
I
F
V
A
L
R
V
--
Y
R
E
A
K
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S
R
V
M
L
M
R
E
H
K
A
L
K
T
-
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
-
D
----------
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
---------------------
16
PsiBlast_PDB
79.89
23%
-163
- C4 -
4AMJ
12
ADRB1_MELGA
A:
[15-286]
----------------------------------------
S
-------------
L
L
M
A
L
V
V
L
L
I
---
V
A
G
N
V
L
V
------
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
---------
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
-------
F
G
A
T
-------
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
-
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
------
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
---
G
C
C
--------
D
F
V
T
-
N
R
A
Y
-
A
I
A
S
S
I
I
S
F
Y
I
P
L
-
L
I
M
I
F
V
A
L
R
V
--
Y
R
E
A
K
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S
R
V
M
L
M
R
E
H
K
A
L
K
T
-
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
-
D
----------
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
---------------------
3
PsiBlast_PDB
79.62
23%
-154
- C4 -
2VT4
8
ADRB1_MELGA
A:
[15-284]
----------------------------------------
S
-------------
L
L
M
A
L
V
V
L
L
I
---
V
A
G
N
V
L
V
------
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
---------
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
-------
F
G
A
T
-------
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
-
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
------
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
---
G
C
C
--------
D
F
V
T
-
N
R
A
Y
-
A
I
A
S
S
I
I
S
F
Y
I
P
L
-
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
-------
K
A
L
K
T
-
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
-
D
----------
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
---------------------
15
PsiBlast_PDB
79.60
23%
-163
- C4 -
2Y04
13
ADRB1_MELGA
A:
[15-286]
----------------------------------------
S
-------------
L
L
M
A
L
V
V
L
L
I
---
V
A
G
N
V
L
V
------
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
---------
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
-------
F
G
A
T
-------
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
-
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
------
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
---
G
C
C
--------
D
F
V
T
-
N
R
A
Y
-
A
I
A
S
S
I
I
S
F
Y
I
P
L
-
L
I
M
I
F
V
A
L
R
V
--
Y
R
E
A
K
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------S
R
V
M
L
M
R
E
H
K
A
L
K
T
-
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
-
D
----------
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
---------------------
33
HHSearch
79.45
18%
-155
- C4 -
2Z73
5
OPSD_TODPA
A:
[35-333]
-------------------------------------
Y
S
L
G
-------------
I
F
I
G
I
C
G
I
I
G
---
C
G
G
N
G
I
V
------
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
---------
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
L
K
K
W
-------
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
-------
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
M
S
H
R
R
A
F
I
M
I
I
--
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
W
G
A
Y
T
L
----
E
G
V
L
C
N
C
S
F
D
Y
I
S
R
-------------
D
S
T
-
T
R
S
N
-
I
-------
L
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
-
H
E
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
-----------------------------------------------------------------------------------------------------------------------------------------------
N
----
A
E
M
---------
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
-
W
S
P
Y
A
V
V
A
L
L
A
Q
F
G
P
-
L
E---------
W
V
T
P
Y
A
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
---------------
5
PsiBlast_PDB
79.43
23%
-153
- C4 -
2YCX
3
ADRB1_MELGA
A:
[15-284]
----------------------------------------
S
-------------
L
L
M
A
L
V
V
L
L
I
---
V
A
G
N
V
L
V
------
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
---------
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
-------
F
G
A
T
-------
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
-
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
------
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
---
G
C
C
--------
D
F
V
T
-
N
R
A
Y
-
A
I
A
S
S
I
I
S
F
Y
I
P
L
-
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
K
I
D
-
R
A
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
----
K
R
V
M
L
M
R
E
H
---
K
A
L
K
T
-
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
-
D
----------
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
F
R
K
A
F
K
-------------------------
4
PsiBlast_PDB
78.33
23%
-156
- C4 -
2YCW
7
ADRB1_MELGA
A:
[15-284]
----------------------------------------
S
-------------
L
L
M
A
L
V
V
L
L
I
---
V
A
G
N
V
L
V
------
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
---------
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
-------
F
G
A
T
-------
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
-
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
------
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
---
G
C
C
--------
D
F
V
T
-
N
R
A
Y
-
A
I
A
S
S
I
I
S
F
Y
I
P
L
-
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
K
I
D
-
R
A
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
----
K
R
V
M
L
M
R
E
H
---
K
A
L
K
T
-
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
-
D
----------
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
--------------------
6
PsiBlast_PDB
77.82
23%
-157
- C4 -
2YCZ
2
ADRB1_MELGA
A:
[15-284]
----------------------------------------
S
-------------
L
L
M
A
L
V
V
L
L
I
---
V
A
G
N
V
L
V
------
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
---------
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
-------
F
G
A
T
-------
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
-
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
------
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
---
G
C
C
--------
D
F
V
T
-
N
R
A
Y
-
A
I
A
S
S
I
I
S
F
Y
I
P
L
-
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
K
I
D
-
R
A
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
----
K
R
V
M
L
M
R
E
H
---
K
A
L
K
T
-
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
-
D
----------
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
--------------------
40
Fugue
77.47
16%
-155
- C4 -
1F88
8
OPSD_BOVIN
A:
[1-348]
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
G
V
V
RSPFEAPQYYLAE
P
W
Q
F
S
M
L
A
-------------
A
Y
M
F
L
L
I
M
L
G
---
F
P
I
N
F
L
T
------
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
---------
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
-------
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
-------
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
--
S
N
F
R
F
G
E
N
H
A
I
M
G
V
--
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
------------
V
G
W
S
R
Y
I
P
E
G
-
M
Q
C
S
C
G
I
DYYTPHE
E
T
N
N
-
E
S
F
V
-
I
-------
Y
M
F
V
V
-
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
-
A
A
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
TTQK
A
E
K
---------
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
-
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
----------
D
F
G
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
STTVSKTETS
Q
V
A
P
A
7
PsiBlast_PDB
77.41
23%
-151
- C4 -
2YCY
6
ADRB1_MELGA
A:
[15-284]
----------------------------------------
S
-------------
L
L
M
A
L
V
V
L
L
I
---
V
A
G
N
V
L
V
------
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
---------
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
-------
F
G
A
T
-------
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
-
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
------
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
---
G
C
C
--------
D
F
V
T
-
N
R
A
Y
-
A
I
A
S
S
I
I
S
F
Y
I
P
L
-
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
--
D
-
R
A
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
----
K
R
V
M
L
M
R
E
H
---
K
A
L
K
T
-
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
-
D
----------
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
--------------------
48
Fugue
76.92
18%
-187
- C3 -
4D08
3
PDE2A_HUMAN
A:
[4-342]
-----
D
D
E
Y
T
K
L
L
H
D
G
I
Q
P
V
-------------
A
A
I
D
S
N
F
A
SFTYTPRSLPEDD
T
S
M
A
I
L
S
M
L
Q
D
M
N
F
I
N
N
Y
K
I
D
C
P
T
L
A
R
F
C
L
M
V
K
K
G
Y
R
D
P
P
Y
H
N
W
M
H
A
F
S
V
S
H
F
C
Y
L
L
Y
K
N
L
E
L
T
N
Y
L
-
E
D
I
E
I
F
A
L
F
I
S
C
M
C
HDLDHR
G
T
N
N
S
F
Q
V
A
S
K
S
V
L
A
A
L
Y
S
S
E
G
-------
S
V
M
E
R
H
H
F
A
Q
A
I
A
I
L
N
T
H
G
C
N
I
F
D
H
F
S
R
K
D
Y
Q
R
M
--
L
D
L
M
R
D
I
I
L
A
T
D
L
A
H
H
L
R
I
F
K
D
L
Q
K
-
M
A
E
V
G
Y
D
R
N
--------
N
--------
K
Q
H
H
-
R
L
L
L
-
C
-------
L
L
M
T
S
-
C
D
L
S
D
Q
T
K
G
W
K
T
T
R
K
I
A
E
L
I
Y
K
E
F
F
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
----
D
L
E
---------
K
A
M
G
N
R
P
M
E
M
M
D
R
E
K
A
-
Y
I
P
E
L
Q
I
S
F
M
E
H
I
A
M
-
P
--------------
I
Y
K
L
L
Q
D
L
F
---
P
K
A
A
E
L
Y
E
R
V
A
S
N
R
E
H
W
T
K
V
S
H
K
F
-
T
I
R
G
L
PSNNSLDFLD-----