@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : O52Z1_HUMAN: (2016-01-12 )
MGIPGLEGLHTWISIPFSFMYIVAVAGNIFLIFLIMTERSLHEPMYLFLSMLASADFLLATAAAPKVLAILWFHSMDISFGSCVSQMFFIHFIFVAESAILLAMAFDRYVAICYPLRYTILTSSAVRKIGIAAVVRSFFICCPFIFLVYRLTYCGRNIIPHSYCEHIARLACGNINVNIIYGLTVALLSTGLDIVLIIISYTMILHSVFQISSWAARFKALSTCGSHICVIFMFYTPAFFSFLAHRFGGKTIPHHIHILVGSLYVLVPPMLNPIIYGVKTKQIKDRVILLFSPISVC
Atome Classification :
(20 SA)
--------------------------------------------....-------------------.--....10........20........30..-----......40.....------...50........60..-..----....70-.-....---...80........------------90----........-.100.....--....110....-------..-.-120--........----130.......140-.....--....150.......160-......---.--170.-------.-...-.-.180-----.......190........----200---..-......----------210.------------------------------------------------------------------------------------------------------------------------------------------------------------------.-------------------------------------------------------------------------------------------------------------------------------------------------------------------...-.----------.220...-------.------...230------------.........240-........250-------..-------.----.--.--.--...260.......270-------........-----280.......290--------------------.----.....-------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------------------------------------MGIP-------------------G--
L
E
G
L
H
T
W
I
SI
P
F
S
F
M
Y
I
V
AVAG
N
I
F
L
I
F
-----
L
I
MTERSLH
E
P
M
Y
------
L
F
L
S
M
LASA
D
F
L
L
ATAA-A
P
----
K
V
L
A
I
L
-
W
-FHSM---DI
S
F
G
S
C
V
S
Q
M
F
F
------------
I
-----
H
F
I
F
V
A
E
S
-
A
I
--
L
L
A
M
A
--
F
D
R
Y
V
A
I
C
Y
P
L
-------
R
Y
-
T
-
I
L---
T
S
S
A
V
R
K
I
----
G
I
A
A
V
V
R
S
F
F
I
---
C
C
P
F
I
--
F
L
V
Y
R
L
T
Y
CGRNII
P
H
S
-
Y
C
E
H
I
A
---
R
--LACG-------N-I
N
V
-
N
-
I
I
Y
G
-----
L
T
V
A
L
L
STG-
L
D
I
V
L
I
I
I
----
S
Y
----
T
M
-
I
L
H
S
V
F
----------
Q
I
S
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
A
R
-
F
----------
K
A
L
S
TCG-------S------
H
I
C
V
--------------
I
F
M
FY
T
P
A
F
F
S
--
F
L
A
H
R
FGGK---------TI-------P----
H
--
H
--
I
--
H
I
L
V
G
S
L
Y
VLVPP
M
L
--------
N
P
I
I
YGVK-----TKQIK
D
R
V
I
L
L
F---------------------S----PISVC-------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
93.12
20%
-166
* C3 *
2RH1
16
ADRB2_HUMAN (first)
A:
[43-477]
-----------------------------------------------------------------------------
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
-----
A
I
A
K
F
E
R
L
Q
T
V
T
N
------
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
----
F
G
A
A
H
I
-
L
-
M
K
M
W
---
T
F
G
N
F
W
C
E
F
W
T
S
I
------------
D
-----
V
L
C
V
T
A
S
I
-
E
T
--
L
C
V
I
A
--
V
D
R
Y
F
A
I
T
S
P
F
-------
K
Y
-
Q
S
L
L
---
T
K
N
K
A
R
V
I
----
I
L
M
V
W
I
V
S
G
L
T
---
S
F
L
P
I
--
Q
M
H
W
Y
-
R
A
T
H
---
Q
E
A
I
-
N
C
Y
A
-----
E
--
E
T
C
C
-------
D
-
F
F
T
-
N
-
Q
A
Y
A
-----
I
A
S
S
I
V
S
F
Y
-
V
P
L
V
I
M
V
F
----
V
Y
----
S
R
-
V
F
Q
E
A
K
----------
R
Q
L
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFC--
L
K
E
-
H
----------
K
A
L
K
T
L
G
-------
I
------
I
M
G
T
--------------
F
T
L
C
W
L
P
F
F
I
V
--
N
I
V
H
V
I
Q
D
N
---------
L
I
-------
R
----
K
--
E
-----
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
--------
N
P
L
I
Y
C
-
R
-----
S
P
D
F
R
I
A
F
Q
E
L
L
---------------------
C
----
L
-----------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
88.73
19%
-174
- C3 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
-----------------------------------------------------------------------------
Y
A
L
S
Y
C
A
L
I
L
A
I
V
F
G
N
G
L
V
C
M
-----
A
V
L
K
E
R
A
L
Q
T
T
T
N
------
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V
-
M
P
----
W
V
V
Y
L
E
-
V
T
G
G
V
W
---
N
F
S
R
I
C
C
D
V
F
V
T
L
------------
D
-----
V
M
M
C
T
A
S
I
-
W
N
--
L
C
A
I
S
--
I
D
R
Y
T
A
V
V
M
P
V
-------
H
Y
-
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
----
I
T
A
V
W
V
L
A
F
A
V
---
S
C
P
L
L
--
F
G
F
N
T
T
-------
G
D
P
T
-
V
C
S
I
---------------------
S
N
----
P
D
F
V
-----
I
Y
S
S
V
V
S
F
Y
-
L
P
F
G
V
T
V
L
----
V
Y
----
A
R
-
I
Y
V
V
L
K
----------
Q
R
R
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWDAYGVP
L
R
E
-
K
----------
K
A
T
Q
M
V
A
-------
I
------
V
L
G
A
--------------
F
I
V
C
W
L
P
F
F
L
T
--
H
V
L
N
T
H
C
Q
T
C--------
H
V
-------
S
----
P
--
E
--
L
---
Y
S
A
T
T
W
L
G
Y
V
N
S
A
L
--------
N
P
V
I
Y
T
T
F
-----
N
I
E
F
R
K
A
F
L
K
I
L
---------------------
S
----
C
-----------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
87.87
23%
-167
- C3 -
4LDO
3
A:
[185-447]
-----------------------------------------------------------------------------
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
-----
A
I
A
K
F
E
R
L
Q
T
V
T
N
------
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
T
K
T
-
W
----------
T
F
G
N
F
W
C
E
F
W
T
S
-----------
I
-----
D
V
L
C
V
T
A
S
I
E
T
--
L
C
V
I
A
--
V
D
R
Y
F
A
I
T
S
P
F
-------
K
Y
Q
S
-
L
L
---
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
------
P
I
Q
--
M
H
W
Y
R
A
T
H
---
Q
E
A
I
N
C
-
Y
A
E
E
---------
T
C
C
-------
D
-
F
F
T
-
N
-
Q
A
Y
A
-----
I
A
S
S
I
V
S
F
Y
-
V
P
L
V
I
M
V
F
----
V
Y
----
S
R
-
V
F
Q
E
A
K
----------
R
Q
L
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
F
AL
K
E
H
-----
K
A
L
K
T
L
G
-------
I
------
I
M
G
T
--------------
F
T
L
C
W
L
P
F
F
I
V
--
N
I
V
H
V
I
Q
D
N
---------
L
I
-------
R
----
K
--
E
--
V
--
Y
I
L
L
N
W
I
G
-
Y
V
N
S
G
F
--------
N
P
L
I
Y
C
R
S
-----
P
D
F
R
I
A
F
Q
E
L
L
C
---------------------
L
----------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
87.61
23%
-170
- C3 -
4LDL
3
ADRB2_HUMAN
A:
[185-447]
-----------------------------------------------------------------------------
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
-----
A
I
A
K
F
E
R
L
Q
T
V
T
N
------
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
T
K
T
-
W
----------
T
F
G
N
F
W
C
E
F
W
T
S
-----------
I
-----
D
V
L
C
V
T
A
S
I
E
T
--
L
C
V
I
A
--
V
D
R
Y
F
A
I
T
S
P
F
-------
K
Y
Q
S
-
L
L
---
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
------
P
I
Q
--
M
H
W
Y
R
A
T
H
---
Q
E
A
I
N
C
-
Y
A
E
E
---------
T
C
C
-------
D
-
F
F
T
-
N
-
Q
A
Y
A
-----
I
A
S
S
I
V
S
F
Y
-
V
P
L
V
I
M
V
F
----
V
Y
----
S
R
-
V
F
Q
E
A
K
----------
R
Q
L
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
F
A
L
K
E
H
-----
K
A
L
K
T
L
G
-------
I
------
I
M
G
T
--------------
F
T
L
C
W
L
P
F
F
I
V
--
N
I
V
H
V
I
Q
D
N
---------
L
I
-------
R
----
K
--
E
--
V
--
Y
I
L
L
N
W
I
G
-
Y
V
N
S
G
F
--------
N
P
L
I
Y
C
R
S
-----
P
D
F
R
I
A
F
Q
E
L
L
C
---------------------
L
----------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
86.87
22%
-173
- C3 -
2VT4
8
ADRB1_MELGA
A:
[14-283]
-----------------------------------------------------------------------------
M
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
-----
A
I
G
S
T
Q
R
L
Q
T
L
T
N
------
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
F
G
A
T
L
V
V
R
G
T
-
W
-
L
---------
W
G
S
F
L
C
E
L
W
T
------------
S
-----
L
D
V
L
C
V
T
A
-
S
I
E
T
L
C
V
I
A
--
I
D
R
Y
L
A
I
T
S
P
F
-------
R
Y
-
Q
-
S
L
---
M
T
R
A
R
A
K
V
----
I
I
C
T
V
----
W
A
---
I
S
A
L
V
--
S
F
L
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
-------
G
C
C
-------
D
-
F
V
T
-
N
-
R
A
Y
A
-----
I
A
S
S
I
I
S
F
Y
-
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
----
R
E
-
A
K
E
Q
I
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
----------
K
A
L
K
T
L
G
-------
I
------
I
M
G
V
--------------
F
T
L
C
W
L
P
F
F
L
V
--
N
I
V
N
V
F
N
R
D
---------
L
V
-------
P
----
D
--
W
--
L
--
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
---------
N
P
I
I
Y
C
R
S
-----
P
D
F
R
K
A
F
K
R
L
L
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
86.83
22%
-176
- C3 -
4GBR
1
ADRB2_HUMAN
A:
[8-270]
-----------------------------------------------------------------------------
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
-----
A
I
A
K
F
E
R
L
Q
T
V
T
N
------
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
T
K
T
-
W
----------
T
F
G
N
F
W
C
E
F
W
T
------------
S
-----
I
D
V
L
C
V
T
A
-
S
I
E
T
L
C
V
I
A
--
V
D
R
Y
F
A
I
T
S
P
F
-------
K
Y
Q
S
-
L
L
---
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
------
P
I
Q
--
M
H
W
Y
R
A
T
H
-------
Q
E
-
A
I
N
C
Y
A
---
E
--
E
T
C
C
-------
D
-
F
F
T
-
N
-
Q
A
Y
A
-----
I
A
S
S
I
V
S
F
Y
-
V
P
L
V
I
M
V
F
----
V
Y
----
S
R
-
V
F
Q
E
A
K
----------
R
Q
L
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
K
-
F
C
L
K
E
H
-----
K
A
L
K
T
L
G
-------
I
------
I
M
G
T
--------------
F
T
L
C
W
L
P
F
F
I
V
--
N
I
V
H
V
I
Q
D
N
---------
L
I
-------
R
----
K
--
E
--
V
--
Y
I
L
L
N
W
I
G
-
Y
V
N
S
G
F
--------
N
P
L
I
Y
C
R
S
-----
P
D
F
R
I
A
F
Q
E
L
L
C
---------------------
L
----------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
86.17
19%
-166
- C3 -
3UON
4
ACM2_HUMAN (first)
A:
[26-457]
-----------------------------------------------------------------------------
I
V
L
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
-----
S
I
K
V
N
R
H
L
Q
T
V
N
N
------
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
-
M
N
----
L
Y
T
L
Y
T
-
V
-
I
G
Y
W
---
P
L
G
P
V
V
C
D
L
W
L
A
L
------------
D
-----
Y
V
V
S
N
A
S
V
-
M
N
--
L
L
I
I
S
--
F
D
R
Y
F
C
V
T
K
P
L
-------
T
Y
-
P
V
K
R
---
T
T
K
M
A
G
M
M
----
I
A
A
A
W
V
L
S
F
I
L
---
W
A
P
A
I
--
L
F
W
Q
F
I
V
G
V
--
R
T
V
E
D
G
-
E
C
Y
I
-------------------
Q
-
F
F
S
-
N
-
A
A
V
T
-----
F
G
T
A
I
A
A
F
Y
-
L
P
V
I
I
M
T
V
----
L
Y
----
W
H
-
I
S
R
A
S
K
----------
S
R
I
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYPP-
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
E
-
K
----------
K
V
T
R
T
I
L
-------
A
------
I
L
L
A
--------------
F
I
I
T
W
A
P
Y
N
V
M
--
V
L
I
N
T
F
C
A
P
---------
C
I
-------
P
----
N
-----
T
--
V
W
T
I
G
Y
W
L
C
Y
I
N
S
T
I
--------
N
P
A
C
Y
A
L
C
-----
N
A
T
F
K
K
T
F
K
H
L
L
---------------------
M
----------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
85.59
23%
-171
- C3 -
4LDE
3
A:
[185-447]
-----------------------------------------------------------------------------
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
-----
A
I
A
K
F
E
R
L
Q
T
V
T
N
------
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
T
K
T
-
W
----------
T
F
G
N
F
W
C
E
F
W
T
S
-----------
I
-----
D
V
L
C
V
T
A
S
I
E
T
--
L
C
V
I
A
--
V
D
R
Y
F
A
I
T
S
P
F
-------
K
Y
Q
S
-
L
L
---
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
------
P
I
Q
--
M
H
W
Y
R
A
T
H
---
Q
E
A
I
N
C
-
Y
A
E
E
---------
T
C
C
-------
D
-
F
F
T
-
N
-
Q
A
Y
A
-----
I
A
S
S
I
V
S
F
Y
-
V
P
L
V
I
M
V
F
----
V
Y
----
S
R
-
V
F
Q
E
A
K
----------
R
Q
L
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
F
AL
K
E
H
-----
K
A
L
K
T
L
G
-------
I
------
I
M
G
T
--------------
F
T
L
C
W
L
P
F
F
I
V
--
N
I
V
H
V
I
Q
D
N
---------
L
I
-------
R
----
K
--
E
--
V
--
Y
I
L
L
N
W
I
G
-
Y
V
N
S
G
F
--------
N
P
L
I
Y
C
R
S
-----
P
D
F
R
I
A
F
Q
E
L
L
C
---------------------
L
----------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
85.33
18%
-166
- C3 -
2KS9
1
NK1R_HUMAN
A:
[35-324]
-----------------------------------------------------------------------------
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
N
V
V
V
M
W
-----
I
I
L
A
H
K
R
M
R
T
V
T
N
------
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
----
V
N
F
T
Y
A
-
V
-
H
N
E
W
---
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
------------
P
-----
I
A
A
V
F
A
S
I
-
Y
S
--
M
T
A
V
A
--
F
D
R
Y
M
A
I
I
H
P
L
-------
Q
P
-
R
-
L
----
S
A
T
A
T
K
V
V
----
I
C
V
I
W
V
L
A
L
L
L
---
A
F
P
Q
G
--
Y
Y
S
T
T
-
E
T
----
M
P
S
R
V
-
V
C
M
I
E
-------
W
P
E
H
-------
P
N
K
I
Y
-
E
-
K
V
Y
H
-----
I
C
V
T
V
L
I
Y
F
-
L
P
L
L
V
I
G
Y
----
A
Y
----
T
V
-
V
G
I
T
L
W
----------
A
S
E
I
PGDSSDRYH
E
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
K
-
R
----------
K
V
V
K
M
M
I
-------
V
------
V
V
C
T
--------------
F
A
I
C
W
L
P
F
H
I
F
--
F
L
L
P
Y
I
N
P
D
---------
L
Y
L------
K
----
K
FI
Q
--
Q
--
V
Y
L
A
I
M
W
L
A
M
S
S
T
M
Y
--------
N
P
I
I
Y
C
C
L
-----
N
D
R
F
R
L
G
F
K
H
A
F
---------------------
R
----
C
C
P
F
I
-------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
84.21
19%
-161
- C3 -
3RZE
5
ENLYS_BPT4 (first)
A:
[11-443]
-----------------------------------------------------------------------------
L
V
V
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
-----
A
V
R
S
E
R
K
L
H
T
V
G
N
------
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
-
M
P
----
M
N
I
L
Y
L
-
L
-
M
S
K
W
---
S
L
G
R
P
L
C
L
F
W
L
S
M
------------
D
-----
Y
V
A
S
T
A
S
I
-
F
S
--
V
F
I
L
C
--
I
D
R
Y
R
S
V
Q
Q
P
L
-------
R
Y
-
L
K
Y
R
---
T
K
T
R
A
S
A
T
----
I
L
G
A
W
F
L
S
F
L
W
---
V
I
P
I
L
--
G
-
W
N
H
--------
R
R
E
D
-
K
C
E
T
-------------------
D
-
F
Y
D
-
V
-
T
W
F
K
-----
V
M
T
A
I
I
N
F
Y
-
L
P
T
L
L
M
L
W
----
F
Y
----
A
K
-
I
Y
K
A
V
R
----------
Q
H
C
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYLH-
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
R
E
-
R
----------
K
A
A
K
Q
L
G
-------
F
------
I
M
A
A
--------------
F
I
L
C
W
I
P
Y
F
I
F
--
F
M
V
I
A
F
C
K
N
---------
C
C
-------
N
----
E
--
H
--
L
---
H
M
F
T
I
W
L
G
Y
I
N
S
T
L
--------
N
P
L
I
Y
P
L
C
-----
N
E
N
F
K
K
T
F
K
R
I
L
---------------------
H
----
I
-----------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
83.13
17%
-162
- C3 -
2Z73
5
OPSD_TODPA
A:
[35-335]
---------------------------------------------------------------------------
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
-----
L
F
T
K
T
K
S
L
Q
T
P
A
N
------
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
----
L
M
T
I
S
C
-
F
-
L
K
K
W
---
I
F
G
F
A
A
C
K
V
Y
G
F
I
------------
G
-----
G
I
F
G
F
M
S
I
-
M
T
--
M
A
M
I
S
--
I
D
R
Y
N
V
I
G
R
P
M
-------
A
A
-
S
K
K
M
---
S
H
R
R
A
F
I
M
----
I
I
F
V
W
L
W
S
V
L
W
---
A
I
G
P
I
--
F
G
W
G
A
Y
T
L
----
E
G
V
L
C
-
N
C
S
F
D
Y
---
I
-----
S
-------
R
-
D
S
T
-
T
-
R
S
N
I
-----
L
C
M
F
I
L
G
F
F
-
G
P
I
L
I
I
F
F
----
C
Y
----
F
N
-
I
V
M
S
V
S
----------
N
H
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
----------------------------------------------------------------------------------------------------------------------------------------------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
A
E
-
M
----------
R
L
A
K
I
S
I
-------
V
------
I
V
S
Q
--------------
F
L
L
S
W
S
P
Y
A
V
V
--
A
L
L
A
Q
F
G
P
L
---------
E
W
-------
V
----
T
--
P
--
Y
--
A
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
--------
N
P
M
I
Y
S
V
S
-----
H
P
K
F
R
E
A
I
S
Q
T
F
---------------------
P
----
W
V
L
T
C
-------------------------------------------------------------------------------------------------------------------------------------------
26
HHSearch
82.90
17%
-176
- C3 -
3EML
13
ENLYS_BPT4
A:
[23-469]
----------------------------------------------------------------------------
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
-----
A
V
W
L
N
S
N
L
Q
N
V
T
N
------
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
----
F
A
I
T
I
S
----
T
G
F
---
C
A
A
C
H
G
C
L
F
I
A
C
F
------------
V
-----
L
V
L
T
Q
S
S
I
-
F
S
--
L
L
A
I
A
--
I
D
R
Y
I
A
I
R
I
P
L
-------
R
Y
-
N
G
L
V
---
T
G
T
R
A
K
G
I
----
I
A
I
C
W
V
L
S
F
A
I
---
G
L
T
P
M
--
L
G
W
N
N
C
G
Q
-------
S
Q
-
G
C
G
E
G
----
Q
--
V
A
C
L
-------
F
-
E
D
V
V
P
M
N
Y
M
V
-----
Y
F
N
F
F
A
C
V
L
-
V
P
L
L
L
M
L
G
----
V
Y
----
L
R
-
I
F
L
A
A
R
----------
R
Q
L
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
R
S
T
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
E
-
V
----------
H
A
A
K
S
L
A
-------
I
------
I
V
G
L
--------------
F
A
L
C
W
L
P
L
H
I
I
--
N
C
F
T
F
F
C
P
D
C--------
S
H
-------
A
----
P
--
L
--
W
--
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
--------
N
P
F
I
Y
A
Y
R
-----
I
R
E
F
R
Q
T
F
R
K
I
I
---------------------
R
----
S
H
V
L
R
-------------------------------------------------------------------------------------------------------------------------------------------
42
Fugue
81.97
15%
-162
- C3 -
1F88
8
OPSD_BOVIN
A:
[1-348]
------------------------------------MN
G
T
E
G
PN
F
Y
V
P
FSNKTGVVRSPFEAPQYYL
A
--
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
-----
V
T
V
Q
H
K
K
L
R
T
P
L
N
------
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
----
T
T
L
Y
T
S
-
L
-
H
G
Y
F
---
V
F
G
P
T
G
C
N
L
E
G
F
F
------------
A
-----
T
L
G
G
E
I
A
L
-
W
S
--
L
V
V
L
A
--
I
E
R
Y
V
V
V
C
K
P
M
-------
S
N
-
F
-
R
F
---
G
E
N
H
A
I
M
G
----
V
A
F
T
W
V
M
A
L
A
C
---
A
A
P
P
L
--
V
G
W
S
R
-------
Y
I
P
E
G
-
M
--------
Q
--
C
S
C
G
I
DYYTPH
E
-
E
T
N
-
N
-
E
S
F
V
-----
I
Y
M
F
V
V
H
F
I
-
I
P
L
I
V
I
F
F
----
C
Y
----
G
Q
-
L
V
F
T
V
K
----------
E
A
A
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
T
-
Q
----------
K
A
E
K
E
V
T
-------
R
------
M
V
I
I
--------------
M
V
I
A
F
L
I
C
W
L
P
--
Y
A
G
V
A
F
Y
I
F
---------
T
H
-------
Q
GSDF
G
--
P
--
I
--
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
--------
N
P
V
I
Y
I
M
M
-----
N
K
Q
F
R
N
C
M
V
T
T
L
C
CGKNPSTTVSKTET------
S
----
Q
V
A
P
A
-------------------------------------------------------------------------------------------------------------------------------------------
47
Fugue
78.40
18%
-180
* C2 *
3ZPJ
-
?
A:
[1-356]
-----------------------------------M
T
T
L
E
E
I
N
L
L
V
E
R
-------------------
G
Y
Y
E
E
A
L
A
K
V
Y
E
I
E
D
P
I
E
Q
V
Q
V
L
T
K
I
V
V
T
I
Y
Q
H
DGP
M
E
W
I
P
S
I
M
E
D
A
M
Y
------
I
A
K
K
L
R
D
P
A
N
K
A
V
A
Y
S
I
-
I
A
----
S
T
L
A
I
M
E
Y
-
E
E
D
A
---
M
D
F
F
N
R
A
I
D
E
A
N
E
------------
I
ES
P
I
E
K
G
M
V
L
S
T
L
-
A
Y
--
H
L
A
I
A
GY
P
D
N
A
L
E
I
F
N
I
A
-------
F
D
-
T
-
I
I
G
AE
T
S
Y
T
H
K
V
D
----
G
I
L
R
I
G
D
L
L
E
K
---
A
G
D
T
L
PS
N
E
A
M
D
F
Y
K
M
A
F
D
I
F
D
K
L
-
H
V
N
Q
R
A
---
A
--
I
V
E
K
-------
K
-
I
E
L
A
K
-
T
V
Y
D
VGL
P
Q
I
R
A
A
L
L
K
G
K
-
N
H
Y
A
L
A
I
I
----
K
K
K
YSG
V
M
-
R
L
I
G
E
L
----------
E
V
A
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
R
-
V
NNME
Y
L
D
V
V
D
K
A
F
E
C
C
E
-------
S
PRFT
D
V
N
V
Q
H
--------------
I
A
R
L
L
T
E
L
G
N
L
--
R
R
A
L
K
F
A
K
E
------------------
I
----
Q
--
N
--
I
--
H
K
R
S
E
A
L
K
A
I
A
L
E
L
V
R
R
KKFEE
V
K
K
I
I
E
S
I
P
-----
D
P
K
I
R
E
E
A
L
N
E
I
---------------------
G
----
T
I
E
---------------------------------------------------------------------------------------------------------------------------------------------
50
Fugue
77.01
19%
-220
- C2 -
3GRE
-
VPS15_YEAST
A:
[1031-1454]
ESIEKFLSTFILPPLRDYKEFGPIQEIVRSPNMGNLRGKLIATL
M
E
N
E
-------------------
P
--
N
S
I
T
S
S
A
V
S
P
G
E
T
P
Y
L
I
T
G
S
D
Q
G
V
I
K
I
W
N
L
K
E
-
I
I
V
G
E
V
Y
S
S
S
L
T
Y
D
CSSTV
T
Q
I
T
M
I
P
N
F
D
A
F
A
V
S
S
K
-
D
G
----
Q
I
I
V
L
K
-
V
-
N
H
Y
Q
Q
ES
E
V
K
F
L
N
C
E
C
I
R
K
I
N
LKNFGKNEYAV
R
-----
M
R
A
F
V
N
E
E
-
K
S
--
L
L
V
A
L
--
T
N
L
S
R
V
I
I
F
D
I
-------
R
--
T
-
L
E
---
R
L
Q
I
I
E
N
S
----
P
R
H
G
A
V
S
S
I
C
I
D
EE
C
C
V
L
I
--
L
G
T
T
R
G
I
I
D
I
W
D
I
R
F
N
V
-
L
I
R
S
W
S
F
G
D
H
--
A
P
I
T
-------
H
-
V
E
V
-
C
-
Q
F
Y
G
-----
K
N
S
V
I
V
V
G
G
S
S
K
T
F
L
T
I
W
----
N
F
----
V
K
G
H
C
Q
Y
A
F
INSDEQPSME
H
F
L
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
G
-
L
----------
E
E
L
N
F
C
G
IRSLNAL
S
------
T
I
S
V
S
ND
K
I
L
L
T
D
EATS
S
I
V
M
F
S
L
N
E
L
S
S
SK
A
V
I
S
P
F
S
D
V
---------
F
I
-------
P
----
T
--
Q
--
V
--
T
---
A
N
L
T
M
L
L
R
K
M
K
--------
H
D
I
I
N
S
I
S
-----
T
C
E
V
D
E
T
P
L
L
V
A
---------------------
C
D
NSG
L
I
G
I
F
Q------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
76.61
16%
-161
- C3 -
3ODU
6
CXCR4_HUMAN (first)
A:
[48-496]
--------------------------------------------------------------------------
K
I
F
L
P
T
I
Y
S
I
I
F
L
T
G
I
V
G
N
G
L
V
I
L
-----
V
M
G
Y
Q
K
K
L
R
S
M
T
D
------
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
-
I
T
-
L
P
----
F
W
A
V
D
A
-
V
--
A
N
W
---
Y
F
G
N
F
L
C
K
A
V
H
V
I
------------
Y
-----
T
V
N
L
Y
S
S
V
-
W
I
--
L
A
F
I
S
--
L
D
R
Y
L
A
I
V
H
A
T
-------
N
S
-
Q
R
P
R
---
K
L
L
A
E
K
V
V
----
Y
V
G
V
W
I
P
A
L
L
L
---
T
I
P
D
F
--
I
F
A
N
V
S
E
-----
A
D
D
R
Y
-
I
C
D
R
F
Y
---
P
-------------
N
-
D
L
W
-
V
-
V
V
F
Q
-----
F
Q
H
I
M
V
G
L
I
-
L
P
G
I
V
I
L
S
----
C
Y
----
C
I
-
I
I
S
K
L
S
----------
H
S
G
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYGSK
G
H
Q
K
-
R
----------
K
A
L
K
T
T
V
-------
I
------
L
I
L
A
--------------
F
F
A
C
W
L
P
Y
Y
I
G
--
I
S
I
D
S
F
I
L
L
EI
I
K
Q
G
C
E
F
E
N
-------
T
----
V
--
H
--
K
--
W
I
S
I
T
E
A
L
A
F
F
H
C
C
L
--------
N
P
I
L
Y
A
F
L
-----
G
A
K
F
K
T
S
A
Q
H
A
L
---------------------
T
----
S
G
R
P
L
-------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
76.22
13%
-157
- C3 -
1U19
14
OPSD_BOVIN
A:
[43-326]
-----------------------------------------------------------------------------
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
-----
V
T
V
Q
H
K
K
L
R
T
P
L
N
------
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
----
T
T
L
Y
T
S
-
L
-
H
G
Y
F
---
V
F
G
P
T
G
C
N
L
E
G
F
F
------------
A
-----
T
L
G
G
E
I
A
L
-
W
S
--
L
V
V
L
A
--
I
E
R
Y
V
V
V
C
K
P
M
-------
S
N
-
F
-
R
F
---
G
E
N
H
A
I
M
G
----
V
A
F
T
W
V
M
A
L
A
C
---
A
A
P
P
L
--
V
G
W
S
R
Y
I
P
----
E
G
M
Q
C
-
S
C
G
I
D
Y
---
Y
---
T
P
H
-------
E
-
E
T
N
-
N
-
E
S
F
V
-----
I
Y
M
F
V
V
H
F
I
-
I
P
L
I
V
I
F
F
----
C
Y
----
G
Q
-
L
V
F
T
V
K
----------
E
A
A
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
QQESA
T
T
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
E
-
K
----------
E
V
T
R
M
V
I
-------
I
------
M
V
I
A
--------------
F
L
I
C
W
L
P
Y
A
G
V
--
A
F
Y
I
F
T
H
Q
G
---------
S
D
-------
F
----
G
--
P
--
I
--
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
--------
N
P
V
I
Y
I
M
M
-----
N
K
Q
F
R
N
C
M
V
T
T
L
---------------------
C
----
C
G
K
N
P
-------------------------------------------------------------------------------------------------------------------------------------------
44
Fugue
76.14
17%
-162
- C3 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
----------------------------------------------------------------------
D
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
-----
A
I
A
K
F
E
R
L
Q
T
V
T
N
------
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
----
F
G
A
A
H
I
-
L
-
M
K
M
W
---
T
F
G
N
F
W
C
E
F
W
T
S
I
------------
D
-----
V
L
C
V
T
A
S
I
-
E
T
--
L
C
V
I
A
--
V
D
R
Y
F
A
I
T
S
P
F
-------
K
Y
-
Q
S
L
L
---
T
K
N
K
A
R
V
I
----
I
L
M
V
W
I
V
S
G
L
T
---
S
F
L
P
I
--
Q
M
-------
H
W
Y
R
A
T
H
Q
-
E
A
I
N
C
Y
---
A
EE
T
C
C
--------
D
-
F
F
T
-
N
-
Q
A
Y
A
-----
I
A
S
S
I
V
S
F
Y
-
V
P
L
V
I
M
V
F
----
V
Y
----
S
R
-
V
F
Q
E
A
K
----------
R
Q
L
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
M
-
L
----------
R
I
D
E
G
L
R
-------
L
------
K
I
Y
K
D
TEGYYTIG-----
I
G
H
L
L
T
K
S
P
S
L
--
N
A
A
K
S
E
L
D
K
---------
A
I
-------
G
----
R
--
N
--
T
NG
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
--------
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
---------------------
A
----
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL
30
HHSearch
75.74
15%
-153
- C3 -
2LNL
-
CXCR1_HUMAN
A:
[39-323]
--------------------------------------------------------------------------
K
Y
V
V
I
I
A
Y
A
L
V
F
L
L
S
L
L
G
N
S
L
V
M
L
-----
V
I
L
Y
S
R
V
G
R
S
V
T
D
------
V
Y
L
L
N
L
A
L
A
D
L
L
F
A
L
-
T
-
L
P
----
I
W
A
A
S
K
---
V
N
G
W
---
I
F
G
T
F
L
C
K
V
V
S
L
L
------------
K
-----
E
V
N
F
Y
S
G
I
-
L
L
--
L
A
C
I
S
--
V
D
R
Y
L
A
I
V
H
A
T
-------
R
T
-
L
-
T
Q
---
K
R
H
L
V
K
F
V
----
C
L
G
C
W
G
L
S
M
N
L
---
S
L
P
F
F
--
L
F
R
Q
A
Y
H
----
P
N
N
S
S
P
-
V
C
Y
E
V
L
---
G
----
N
D
-------
T
-
A
K
W
-
R
-
M
V
L
R
-----
I
L
P
H
T
F
G
F
I
-
V
P
L
F
V
M
L
F
----
C
Y
----
G
F
-
T
L
R
T
L
F
----------
K
A
H
M
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
Q
K
-
H
----------
R
A
M
R
V
I
F
-------
A
------
V
V
L
I
--------------
F
L
L
C
W
L
P
Y
N
L
V
--
L
L
A
D
T
L
M
R
T
---------
Q
V
IQE
S
C
E
R
R
----
N
--
N
I
G
R
--
A
L
D
A
T
E
I
L
G
F
L
H
S
C
L
--------
N
P
I
I
Y
A
F
I
-----
G
Q
N
F
R
H
G
F
L
K
I
L
---------------------
A
----
M
H
G
---------------------------------------------------------------------------------------------------------------------------------------------
43
Fugue
75.21
14%
-143
- C3 -
1U19
15
OPSD_BOVIN
A:
[4-349]
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