@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR1B1_HUMAN: (2016-01-12 )
MMSFAPNASHSPVFLLLGFSRANISYTLLFFLFLAIYLTTILGNVTLVLLISWDSRLHSPMYYLLRGLSVIDMGLSTVTLPQLLAHLVSHYPTIPAARCLAQFFFFYAFGVTDTLVIAVMALDRYVAICDPLHYALVMNHQRCACLLALSWVVSILHTMLRVGLVLPLCWTGDAGGNVNLPHFFCDHRPLLRASCSDIHSNELAIFFEGGFLMLGPCALIVLSYVRIGAAILRLPSAAGRRRAVSTCGSHLTMVGFLYGTIICVYFQPPFQNSQYQDMVASVMYTAITPLANPFVYSLHNKDVKGALCRLLEWVKVDP
Atome Classification :
(20 SA)
------------.........10........20........30.......----------------.40........50.-----------......-----.60........70.....--...-80........90.---......----.100.......110........120.......130---------------.........140.......150--........160....------.--------------..170.......180.......190--....-------.-...---200----........-.210.-......220.-----------....-------..230-------.---------------..---------....-.-----------.-----------------240---.....--....250.....------------------..260-------..-..----..----..-270-.---.---..---..-----------..280..-...--.-.290.......300.-----.......310------------------.......--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------MMSFAPNASHS
P
V
F
L
L
L
GFSRAN
I
S
Y
T
L
L
F
F
L
F
L
A
I
Y
L
----------------
T
T
I
LGN
V
T
L
V
L
L
IS-----------WDSRLH-----
S
P
M
Y
Y
L
L
R
G
L
S
V
I
D
MGLS--TV
T
-
L
P
Q
L
L
A
H
L
V
S
HYP---T
I
P
A
A
R
----
C
L
A
Q
F
F
F
F
Y
A
FGV-
T
D
T
L
V
I
A
V
M
A
L
D
R
Y
V
A
I
C
D
-----------------
P
L
H
Y
A
L
V
MNH
Q
R
C
A
C
L
L
A
L
S
W
---
V
V
S
I
L
H
T
M
L
RV
G
L
V
L
------
P
--------------
L
C
WTGDAGGNVNL
P
H
F
FCDHR
P
L
L
---
R
A
S
C
-------S-DIH---S------N
E
L
A
I
F
F
E-G
G
F
L
M
-L
G
P
C
A
L
I
V
L
S
-----------
Y
V
R
I
-------
G
A
A
---------
I
---------------
L
R---------LPSA-A-----------G-----------------R-----
R
R
A
V
S
--
T
C
G
S
H
L
T
M
V
G
F
L
------------------
Y
G
T
I
--------
I
C
-
V
Y
----FQ----PP-FQ--N---
S
---
Q
Y
---
Q
D
-----------
M
V
A
S
V
M
Y
-
T
A
I
--T-PLAN
P
F
V
Y
S
LHNK-
D
-----
V
K
G
A
L
C
R
L
L
-------------------
E
W
V
KVDP--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
95.72
22%
-158
- C6 -
3UZC
1
AA2AR_HUMAN
A:
[14-304]
---------------------------------------------
L
A
I
A
V
----------------
L
A
I
L
G
N
V
L
V
C
W
A
V
W
-----------
L
N
S
N
L
Q
-----
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
--
V
L
A
-
I
P
--
F
A
I
T
I
S
T
G
F
---
C
A
A
C
H
G
----
C
L
F
I
A
C
F
V
L
V
L
A
Q
-
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
-----------------
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
---
V
L
S
-----
F
A
I
G
L
T
P
------
M
--------------
L
G
W
N
-----
N
C
G
Q
P
--------
G
C
GEG
Q
V
A
C
L
F
-----
E
-
D
V
V
---
P
------
M
N
Y
M
V
Y
F
N
-
F
F
A
C
V
-
L
V
P
L
L
L
M
L
G
V
-----------
Y
L
R
I
-------
F
A
A
---------
A
---------------
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
E
-
R
-----------
A
-----------------
R
S
T
L
--
Q
K
E
V
H
--
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
------------
L
H
I
I
--------
N
C
F
T
F
----
F
C
----
P
D
-
C
S
--
H
---
A
---
P
L
---
W
L
-----------
M
Y
L
A
I
V
L
-
A
H
T
--
N
-
S
V
V
N
P
F
I
Y
A
Y
R
I
R
-
E
-----
F
R
Q
T
F
R
K
I
I
-------------------
R
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
95.31
22%
-158
- C6 -
3RFM
1
AA2AR_HUMAN
A:
[14-304]
---------------------------------------------
L
A
I
A
V
----------------
L
A
I
L
G
N
V
L
V
C
W
A
V
W
-----------
L
N
S
N
L
Q
-----
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
--
V
L
A
-
I
P
--
F
A
I
T
I
S
T
G
F
---
C
A
A
C
H
G
----
C
L
F
I
A
C
F
V
L
V
L
A
Q
-
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
-----------------
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
---
V
L
S
-----
F
A
I
G
L
T
P
------
M
--------------
L
G
W
N
-----
N
C
G
Q
P
--------
G
C
GEG
Q
V
A
C
L
F
-----
E
-
D
V
V
---
P
------
M
N
Y
M
V
Y
F
N
-
F
F
A
C
V
-
L
V
P
L
L
L
M
L
G
V
-----------
Y
L
R
I
-------
F
A
A
---------
A
---------------
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
E
-
R
-----------
A
-----------------
R
S
T
L
--
Q
K
E
V
H
--
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
------------
L
H
I
I
--------
N
C
F
T
F
----
F
C
----
P
D
-
C
S
--
H
---
A
---
P
L
---
W
L
-----------
M
Y
L
A
I
V
L
-
A
H
T
--
N
-
S
V
V
N
P
F
I
Y
A
Y
R
I
R
-
E
-----
F
R
Q
T
F
R
K
I
I
-------------------
R
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
95.23
22%
-156
- C6 -
3REY
1
AA2AR_HUMAN
A:
[14-304]
---------------------------------------------
L
A
I
A
V
----------------
L
A
I
L
G
N
V
L
V
C
W
A
V
W
-----------
L
N
S
N
L
Q
-----
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
--
V
L
A
-
I
P
--
F
A
I
T
I
S
T
G
F
---
C
A
A
C
H
G
----
C
L
F
I
A
C
F
V
L
V
L
A
Q
-
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
-----------------
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
---
V
L
S
-----
F
A
I
G
L
T
P
------
M
--------------
L
G
W
N
-----
N
C
G
Q
P
--------
G
C
GEG
Q
V
A
C
L
F
-----
E
-
D
V
V
---
P
------
M
N
Y
M
V
Y
F
N
-
F
F
A
C
V
-
L
V
P
L
L
L
M
L
G
V
-----------
Y
L
R
I
-------
F
A
A
---------
A
---------------
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
E
-
R
-----------
A
-----------------
R
S
T
L
--
Q
K
E
V
H
--
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
------------
L
H
I
I
--------
N
C
F
T
F
----
F
C
----
P
D
-
C
S
--
H
---
A
---
P
L
---
W
L
-----------
M
Y
L
A
I
V
L
-
A
H
T
--
N
-
S
V
V
N
P
F
I
Y
A
Y
R
I
R
-
E
-----
F
R
Q
T
F
R
K
I
I
-------------------
R
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
94.77
22%
-156
- C6 -
3PWH
1
?
A:
[14-304]
---------------------------------------------
L
A
I
A
V
----------------
L
A
I
L
G
N
V
L
V
C
W
A
V
W
-----------
L
N
S
N
L
Q
-----
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
--
V
L
A
-
I
P
--
F
A
I
T
I
S
T
G
F
---
C
A
A
C
H
G
----
C
L
F
I
A
C
F
V
L
V
L
A
Q
-
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
-----------------
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
---
V
L
S
-----
F
A
I
G
L
T
P
------
M
--------------
L
G
W
N
-----
N
C
G
Q
P
--------
G
C
GEG
Q
V
A
C
LF-----
E
-
D
V
V
---
P
------
M
N
Y
M
V
Y
F
N
-
F
F
A
C
V
-
L
V
P
L
L
L
M
L
G
V
-----------
Y
L
R
I
-------
F
A
A
---------
A
---------------
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
E
-
R
-----------
A
-----------------
R
S
T
L
--
Q
K
E
V
H
--
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
------------
L
H
I
I
--------
N
C
F
T
F
----
F
C
----
P
D
-
C
S
--
H
---
A
---
P
L
---
W
L
-----------
M
Y
L
A
I
V
L
-
A
H
T
--
N
-
S
V
V
N
P
F
I
Y
A
Y
R
I
R
-
E
-----
F
R
Q
T
F
R
K
I
I
-------------------
R
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
94.45
22%
-158
- C6 -
3UZA
1
AA2AR_HUMAN
A:
[14-304]
---------------------------------------------
L
A
I
A
V
----------------
L
A
I
L
G
N
V
L
V
C
W
A
V
W
-----------
L
N
S
N
L
Q
-----
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
--
V
L
A
-
I
P
--
F
A
I
T
I
S
T
G
F
---
C
A
A
C
H
G
----
C
L
F
I
A
C
F
V
L
V
L
A
Q
-
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
-----------------
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
---
V
L
S
-----
F
A
I
G
L
T
P
------
M
--------------
L
G
W
N
-----
N
C
G
Q
P
--------
G
C
GEG
Q
V
A
C
L
F
-----
E
-
D
V
V
---
P
------
M
N
Y
M
V
Y
F
N
-
F
F
A
C
V
-
L
V
P
L
L
L
M
L
G
V
-----------
Y
L
R
I
-------
F
A
A
---------
A
---------------
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
E
-
R
-----------
A
-----------------
R
S
T
L
--
Q
K
E
V
H
--
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
------------
L
H
I
I
--------
N
C
F
T
F
----
F
C
----
P
D
-
C
S
--
H
---
A
---
P
L
---
W
L
-----------
M
Y
L
A
I
V
L
-
A
H
T
--
N
-
S
V
V
N
P
F
I
Y
A
Y
R
I
R
-
E
-----
F
R
Q
T
F
R
K
I
I
-------------------
R
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
88.49
21%
-147
- C6 -
3VG9
8
?
A:
[14-304]
---------------------------------------------
L
A
I
A
V
----------------
L
A
I
L
G
N
V
L
V
C
W
A
V
W
-----------
L
N
S
N
L
Q
-----
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
--
V
L
A
-
I
P
--
F
A
I
T
I
S
T
G
F
---
C
A
A
C
H
G
----
C
L
F
I
A
C
F
V
L
V
L
T
Q
-
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
-----------------
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
---
V
L
S
-----
F
A
I
G
L
T
P
------
M
--------------
L
G
W
N
N
C
G
Q
-------
S
Q
G
C
G
E
G
Q
V
---
A
C
L
F
-------
E
-
D
V
V
---
P
------
M
N
Y
M
V
Y
F
N
-
F
F
A
C
V
-
L
V
P
L
L
L
M
L
G
V
-----------
Y
L
R
I
-------
F
L
A
---------
A
---------------
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
G
E
-
R
-----------
A
-----------------
R
S
T
L
--
Q
K
E
V
H
--
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
------------
L
H
I
I
--------
N
C
F
T
F
----
F
C
----
P
D
-
C
S
--
H
---
A
---
P
L
---
W
L
-----------
M
Y
L
A
I
V
L
-
S
H
T
--
N
-
S
V
V
N
P
F
I
Y
A
Y
R
I
R
-
E
-----
F
R
Q
T
F
R
K
I
I
-------------------
R
S
H
V
L
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
88.32
21%
-152
- C6 -
3VGA
1
AA2AR_HUMAN
A:
[14-304]
---------------------------------------------
L
A
I
A
V
----------------
L
A
I
L
G
N
V
L
V
C
W
A
V
W
-----------
L
N
S
N
L
Q
-----
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
--
V
L
A
-
I
P
--
F
A
I
T
I
S
T
G
F
---
C
A
A
C
H
G
----
C
L
F
I
A
C
F
V
L
V
L
T
Q
-
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
-----------------
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
---
V
L
S
-----
F
A
I
G
L
T
P
------
M
--------------
L
G
W
N
N
C
G
Q
-------
S
Q
G
C
G
E
G
Q
V
---
A
C
L
F
-------
E
-
D
V
V
---
P
------
M
N
Y
M
V
Y
F
N
-
F
F
A
C
V
-
L
V
P
L
L
L
M
L
G
V
-----------
Y
L
R
I
-------
F
L
A
---------
A
---------------
R
R
Q
L
K
Q
M
E
S
Q
P
L
P
G
E
-
R
-----------
A
-----------------
R
S
T
L
--
Q
K
E
V
H
--
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
------------
L
H
I
I
--------
N
C
F
T
F
----
F
C
----
P
D
-
C
S
--
H
---
A
---
P
L
---
W
L
-----------
M
Y
L
A
I
V
L
-
S
H
T
--
N
-
S
V
V
N
P
F
I
Y
A
Y
R
I
R
-
E
-----
F
R
Q
T
F
R
K
I
I
-------------------
R
S
H
V
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
HHSearch
84.57
17%
-148
- C6 -
2Z73
5
OPSD_TODPA
A:
[33-333]
------------------------------------
V
Y
Y
S
L
G
I
F
I
G
I
C
G
I
----------------
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
-----------
K
T
K
S
L
Q
-----
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
--
L
V
N
G
F
P
L
M
T
I
S
C
F
L
K
K
W
---
I
F
G
F
A
A
----
C
K
V
Y
G
F
I
G
G
I
F
G
F
-
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
-----------------
P
M
A
A
S
K
K
M
S
H
R
R
A
F
I
M
I
I
F
V
W
---
L
W
S
V
L
W
A
I
G
P
I
F
G
W
G
------
A
--------------
Y
T
L
--------
E
G
V
L
C
N
C
S
F
D
Y
I
S
----------------
R
D
S
---
T
------
T
R
S
N
I
L
C
M
-
F
I
L
G
F
-
F
G
P
I
L
I
I
F
F
C
-----------
Y
F
N
I
-------
V
M
S
---------
V
---------------
S
N
---------
H
E
K
E
-
M
-----------
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
-----
N
A
E
M
R
--
L
A
K
-
I
S
I
V
I
V
S
Q
------------------
F
L
L
S
--------
W
S
-
P
Y
----
A
V
V
A
L
L
A
Q
-
F
G
--
P
LEW
V
---
T
P
---
Y
A
-----------
A
Q
L
P
V
M
F
-
A
K
A
--
S
-
A
I
H
N
P
M
I
Y
S
V
S
H
P
-
K
-----
F
R
E
A
I
S
Q
T
F
-------------------
P
W
V
L
T
C
C
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
83.89
22%
-138
- C6 -
3EML
9
ENLYS_BPT4
A:
[29-308]
---------------------------------------------
L
A
I
A
V
----------------
L
A
I
L
G
N
V
L
V
C
W
A
V
W
-----------
L
N
S
N
L
Q
-----
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
--
V
L
A
-
I
P
--
F
A
I
T
I
S
T
G
F
---
C
A
A
C
H
G
----
C
L
F
I
A
C
F
V
L
V
L
T
Q
-
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
-----------------
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
---
V
L
S
-----
F
A
I
G
L
T
P
------
M
--------------
L
G
W
N
-----
N
C
G
Q
-------
S
Q
G
C
GEG
Q
V
A
C
LF-----
E
-
D
V
V
---
P
------
M
N
Y
M
V
Y
F
N
-
F
F
A
C
V
-
L
V
P
L
L
L
M
L
G
V
-----------
Y
L
R
I
-------
F
L
A
A
R
RQLN
I
F
E
M
---------------
L
R
---------
I
D
E
G
-
L
-----------
R
-----------------
L
-----
K
I
Y
K
D
--
T
E
G
Y
Y
T
I
G
I
G
H
L
------------------
L
T
--------------------
K
----
S
P
-
S
L
--
N
---
A
---
A
K
---
S
E
-----------
L
D
K
A
I
G
R
-
N
T
N
--
G
-
V
I
T
K
D
E
A
E
K
L
F
N
Q
-
D
-----
V
D
A
A
V
R
G
I
L
-------------------
R
N
A
K
L
K
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
Fugue
81.86
17%
-134
- C6 -
1F88
8
OPSD_BOVIN
A:
[1-348]
-MN
G
T
E
G
PNFYV
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
----------------
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
-----------
Q
H
K
K
L
R
-----
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
--
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
---
V
F
G
P
T
G
----
C
N
L
E
G
F
F
A
T
L
G
G
E
-
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
-----------------
P
M
S
-
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
---
V
M
A
L
A
C
A
A
------
P
------
P
--------------
L
-----
V
G
W
S
R
Y
I
P
E
G
-------
M
---
Q
C
S
C
-------
G
I
D
Y
Y
---
T
PHEETN
N
E
S
F
V
I
Y
M
-
F
V
V
H
F
-
I
I
P
L
I
V
I
F
F
C
-----------
Y
G
Q
L
VFTVKEA
A
A
S
---------
A
---------------
T
T
---------
Q
K
A
E
-
K
-----------
E
-----------------
V
-----
T
R
M
V
I
--
I
M
V
I
A
F
L
I
C
W
L
P
------------------
Y
A
G
V
--------
A
F
-
Y
I
----
F
T
----
H
Q
-
G
S
--
D
---
F
---
G
P
---
I
F
-----------
M
T
I
P
A
F
F
-
A
K
T
--
S
-
A
V
Y
N
P
V
I
Y
I
M
M
N
K
-
Q
-----
F
R
N
C
M
V
T
T
L
--------------------
C
C
G
K
N
P
STTVSKTETS
Q
V
A
P
A-----------------------------------------------------------------------------------------------------------------------------------------------------------------
60
Fugue
79.76
18%
-144
- C6 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
---------------------------------
D
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
----------------
A
I
V
F
G
N
V
L
V
I
T
A
I
A
-----------
K
F
E
R
L
Q
-----
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
--
L
A
V
-
V
P
F
G
A
A
H
I
L
M
K
M
W
---
T
F
G
N
F
W
----
C
E
F
W
T
S
I
D
V
L
C
V
T
-
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
-----------------
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
---
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
------
Y
--------------
R
-
A
T
H
Q
E
A
I
N
C
Y
A
E
E
T
C
C
D
----------------------
F
F
---
T
------
N
Q
A
Y
A
I
A
S
-
S
I
V
S
F
-
Y
V
P
L
V
I
M
V
F
V
-----------
Y
S
R
V
-------
F
Q
E
---------
A
---------------
K
R
---------
Q
L
N
I
-
F
-----------
E
-----------------
M
-----
L
R
I
D
E
--
G
L
R
L
K
I
Y
K
D
T
E
G
------------------
Y
Y
T
I
G-------
I
G
-
H
L
----
L
T
----
K
S
-
P
S
--
L
---
N
---
A
A
---
K
S
-----------
E
L
D
K
A
I
G
-
R
N
T
--
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
-
D
-----
V
D
A
A
V
R
G
I
L
-------------------
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL---------------------
58
Fugue
77.66
16%
-126
- C6 -
1U19
15
OPSD_BOVIN
A:
[4-349]
-MN
G
T
E
G
PNFYV
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
----------------
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
-----------
Q
H
K
K
L
R
-----
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
--
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
---
V
F
G
P
T
G
----
C
N
L
E
G
F
F
A
T
L
G
G
E
-
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
-----------------
P
M
S
----------------
N
F
---
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
------
V
--------------
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
---
M
---
Q
C
S
C
G
I
DYYTP
H
-
E
E
T
---
N
------
N
E
S
F
V
I
Y
M
-
F
V
V
H
F
-
I
I
P
L
I
V
I
F
F
C
-----------
Y
G
Q
L
-------
V
F
T
---------
V
---------------
K
E
---------
A
A
A
Q
-
Q
-----------
Q
-----------------
E
-----
S
A
T
T
Q
--
K
A
E
K
E
V
T
R
M
V
I
I
------------------
M
V
I
A
--------
F
L
-
I
C
----
W
L
----
P
Y
-
A
G
--
V
---
A
---
F
Y
---
I
F
T
H
QGSDFGPIF
M
T
I
P
A
F
F
-
A
K
T
--
S
-
A
V
Y
N
P
V
I
Y
I
M
M
N
K
-
Q
-----
F
R
N
C
M
V
T
T
L
C
CGKNPLGDDEA
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
HHSearch
76.74
15%
-138
- C6 -
1U19
14
OPSD_BOVIN
A:
[41-326]
--------------------------------------
S
M
L
A
A
Y
M
F
L
L
I
M
----------------
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
-----------
Q
H
K
K
L
R
-----
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
--
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
---
V
F
G
P
T
G
----
C
N
L
E
G
F
F
A
T
L
G
G
E
-
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
-----------------
P
M
S
N
F
R
F
-
G
E
N
H
A
I
M
G
V
A
F
T
W
---
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
------
R
----------------
Y
I
----
P
E
--
G
M
Q
C
S
C
G
I
D
Y
Y
T
---
P
----------
H
-
E
E
T
---
N
------
N
E
S
F
V
I
Y
M
-
F
V
V
H
F
-
I
I
P
L
I
V
I
F
F
C
-----------
Y
G
Q
L
-------
V
F
T
---------
V
---------------
K
E
---------
A
A
A
Q
-
Q
-----------
Q
-----------------
E
SA
T
T
Q
K
A
E
K
E
--
V
T
R
-
M
V
I
I
M
V
I
A
------------------
F
L
I
C
--------
W
L
-
P
Y
----
A
G
V
A
F
Y
I
F
T
H
Q
--
G
---
S
DF-
G
P
---
I
F
-----------
M
T
I
P
A
F
F
-
A
K
T
--
S
-
A
V
Y
N
P
V
I
Y
I
M
M
N
K
-
Q
-----
F
R
N
C
M
V
T
T
L
-------------------
C
C
G
K
N
P
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
Fugue
75.87
22%
-150
- C1 -
3P4G
16
?
A:
[23-323]
-------HSFDH
Y
I
G
S
A
F
D
A
S
N
N
N
V
A
V
-----
T
G
N
V
S
A
T
L
N
--
V
L
A
G
D
D
K
----------------
V
S
I
D
G
N
V
E
D
V
L
V
A
A
-----------
N
V
A
V
L
D
MGTGN
D
Q
L
Y
V
A
G
D
V
L
G
K
I
D
A
G
T
G
N
D
E
I
Y
-
I
K
G
D
V
S
A
A
V
D
A
G
T
---
G
N
D
E
V
Y
----
I
G
G
N
L
S
G
D
L
D
A
G
T
D
N
D
N
I
Q
I
G
G
D
V
N
A
A
L
N
A
--
G
-----------------
T
G
N
D
N
L
I
I
G
H
D
-
V
S
G
I
V
N
M
G
T
D
N
D
T
V
E
V
G
R
T
I
N
A
S
G
K
V
L
LDTGD
D
S
--------------
L
L
V
S
G
D
L
F
G
E
V
D
--------------------------
G
-
G
T
G
---
N
------
D
T
I
I
I
A
G
K
V
S
G
N
I
Q
-
G
G
T
-----------------------------
G
N
D
---------
I
---------------
V
R
---------
V
Q
S
Q
-
V
-----------
W
-----------------
A
-----
E
A
N
I
S
LG
T
G
D
D
V
L
I
V
E
H
E
L
------------------
H
G
T
V
A
GNEGD
D
S
I
Y
-
L
K
----
F
Y
----
T
K
-
E
Q
--
Y
---
N
---
N
N
---
S
D
-----------
L
R
N
R
V
------------
A
N
F
E
H
I
R
V
S
D
G
-
V
-----
V
K
G
S
P
A
D
F
A
-------------------
D
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
HHSearch
75.81
15%
-143
- C6 -
2KS9
1
NK1R_HUMAN
A:
[34-324]
---------------------------------------
L
W
A
A
A
Y
T
V
I
V
V
----------------
T
S
V
V
G
N
V
V
V
M
W
I
I
L
-----------
A
H
K
R
M
R
-----
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
--
A
F
N
-
T
V
V
N
F
T
Y
A
V
H
N
E
W
---
Y
Y
G
L
F
Y
----
C
K
F
H
N
F
F
P
I
A
A
V
F
-
A
S
I
Y
S
M
T
A
V
A
F
D
R
Y
M
A
I
I
H
-----------------
P
L
Q
P
R
L
--
S
A
T
A
T
K
V
V
I
C
V
I
W
---
V
L
A
L
L
L
A
F
P
Q
G
Y
Y
-
S
------
T
--------------
T
E
T
--------
M
P
S
R
V
V
C
M
I
E
W
P
E
---
H
P
-----------
N
K
I
---
Y
------
E
K
V
Y
H
I
C
V
-
T
V
L
I
Y
-
F
L
P
L
L
V
I
G
Y
A
-----------
Y
T
V
V
-------
G
I
T
---------
L
---------------
W
A
---------
S
E
I
P
-
G
DSSDRYH
E
Q
V
S
A
-----------------
K
-----
R
K
V
V
K
--
M
M
I
V
V
V
C
T
F
A
I
C
------------------
W
L
P
F
--------
H
I
-
F
F
----
L
L
----
P
Y
-
I
N
--
P
---
D
LYL
K
K
FI
Q
Q
V
-----------
Y
L
A
I
M
W
L
-
A
M
S
--
S
-
T
M
Y
N
P
I
I
Y
C
C
L
N
D
-
R
-----
F
R
L
G
F
K
H
A
F
-------------------
R
C
C
P
F
I
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
Fugue
74.48
17%
-127
- C6 -
3ODU
6
CXCR4_HUMAN (first)
A:
[37-502]
-----------------
P
C
F
R
E
E
---------
N
A
N
F
N
K
I
F
L
P
T
I
Y
S
I
I
F
L
----------------
T
G
I
V
G
N
G
L
V
I
L
V
M
G
-----------
Y
Q
K
K
L
R
-----
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
--
I
T
--
L
P
F
W
A
V
D
A
V
A
N
W
Y
---
F
-
G
N
F
L
----
C
K
A
V
H
V
I
Y
T
V
N
L
Y
-
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
H
-----------------
A
T
N
S
Q
R
P
R
K
L
L
A
E
K
V
V
Y
V
G
V
W
---
I
P
A
L
L
-----
L
T
I
P
D
------
F
--------------
I
F
A
N
V
S
E
A
D
D
R
---
Y
I
C
D
R
F
Y
P
N
D
---
L
W
V
V
-------
V
-
F
Q
F
---
Q
------
H
I
M
V
G
L
I
L
-
P
G
I
V
I
-
L
S
C
Y
C
I
I
I
S
K
-----------
L
S
H
S
-------
G
S
N
---------
I
---------------
F
E
---------
M
L
R
I
D
E
-----------
G
-----------------
L
-----
R
L
K
I
Y
--
K
D
T
E
G
Y
Y
T
I
G
-----------------------
I
--------
G
H
-
L
L
----
T
K
----
S
P
-
S
L
--
N
---
A
---
A
K
---
S
E
-----------
L
D
K
A
I
G
R
-
N
T
N
--
G
-
V
I
T
K
D
E
A
E
K
L
F
N
Q
-
D
-----
V
D
A
A
V
R
G
I
L
-------------------
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYGSK
G
H
Q
K
R
K
A
L
K
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
Y
Y
I
G
I
S
I
D
S
F
I
L
L
EI
I
K
Q
G
C
E
F
E
N
T
V
H
K
W
I
S
I
T
E
A
L
A
F
FHCC
L
N
P
I
L
Y
AFLGAKFKTS
A
Q
H
A
L
TSGRPLEVLFQ
61
Fugue
67.97
18%
-131
- C3 -
4WGV
-
?
A:
[5-399]
-----------------
V
G
Y
M
D
P
G
N
W
I
T
S
M
Q
G
G
A
Q
Y
G
Y
T
L
L
F
V
I
L
I
S
S
L
A
----------------
A
M
L
L
Q
S
M
T
V
R
L
G
I
A
T
GKD
L
A
Q
M
T
R
H
F
L
S
K
P
V
-----
A
I
I
F
W
I
I
A
E
L
A
I
I
A
T
D
I
A
--
E
V
I
-
G
S
A
I
A
L
D
L
I
F
G
I
P
---
L
I
V
G
A
L
I
T
V
F
D
V
F
L
L
L
F
I
M
R
F
G
F
-
R
K
I
E
A
I
V
G
T
L
I
F
T
V
L
A
I
F
V
F
E
VFISSPQLTDILNGF
V
P
H
K
E
I
V
T
N
Q
G
I
L
Y
I
A
L
G
I
I
G
---
A
T
I
M
P
H
N
L
Y
L
H
S
S
I
V
------
Q
S
R
K
Y
D
R
HDNEEK
A
Q
A
I
K
Y
A
T
I
D
S
N
L
Q
L
S
I
A
F
V
V
N
C
L
L
L
---
T
L
G
A
-------
A
-
L
F
F
GTK
T
------
N
D
L
G
G
F
Y
D
-
L
Y
H
A
L
K
T
E
P
V
L
G
A
T
L
G
-----------
G
V
M
S
-------
T
L
F
---------
A
---------------
V
A
---------
L
L
A
S
-
G
-----------
Q
-----------------
N
-----
S
T
I
T
G
--
T
L
A
G
Q
I
V
M
E
G
F
L
R
L
S
I
P
N
W
L
R
R
L
I
T
R
S
L
A
V
I
P
V
I
--------
I
C
-
L
I
----
I
F
----
K
G
-
N
S
--
E
---
K
---
I
E
---
Q
L
-----------
L
V
F
S
Q
V
F
-
L
S
I
A
L
P
-
F
S
L
I
P
L
Q
L
A
T
S
N
K
-
K
LMGPF
I
N
K
T
W
V
N
I
I
-------------------
S
W
T
L
I
V
I
L
S
G
L
N
V
Y-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
HHSearch
67.40
21%
-161
- C6 -
3EML
8
ENLYS_BPT4
A:
[23-222]
---------------------------------------
V
Y
I
T
V
E
L
A
I
A
V
----------------
L
A
I
L
G
N
V
L
V
C
W
A
V
W
-----------
L
N
S
N
L
Q
-----
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
--
V
L
A
-
I
P
F
A
I
T
I
S
--
T
G
F
---
C
A
A
C
H
G
----
C
L
F
I
A
C
F
V
L
V
L
T
Q
-
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
-----------------
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
---
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
------
N
--------------
C
G
Q
-----------
S
Q
G
C
G
E
G
Q
------
V
A
C
-------
L
-
F
E
D
---
V
VP----
M
N
Y
M
V
Y
F
N
-
F
F
A
C
V
-
L
V
P
L
L
L
M
L
G
V
-----------
Y
L
R
I
-------
F
L
A
---------
A
---------------
R
R
---------
Q
L
N
I
-
F
-----------
E
-----------------
M
-----
L
R
I
D
E
--
G
L
R
L
K
I
Y
K
D
T
E
G
------------------
Y
Y
T
I
--------
G
I
-
G
H
----
L
L
----
T
K
-
S
P
--
S
---
L
---
N
A
---
A
K
-----------
S
E
L
D
K
A
I
-
G
R
N
--
T
-
N
G
V
I
T
K
D
E
A
E
K
L
F
-
N
-----
Q
D
V
D
A
A
V
R
G
-------------------
I
L
R
N
A
K
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
Fugue
67.35
18%
-161
- C2 -
4L9B
5
?
A:
[2-393]
VLKGINFP
E
N
E
A
S
I
L
D
L
A
M
Q
N
R
S
G
V
L
D
G
M
T
I
D
I
L
N
T
T
S
N
Q
L
A
L
F
H
G
T
A
V
L
QG
Y
G
I
E
I
TGAPD
V
L
V
D
T
T
G
Q
S
N
E
T
M
L
L
C
L
T
-----------
I
D
L
N
Q
V
-----
N
V
P
S
G
T
A
V
D
Y
K
Q
I
R
L
E
F
L
--
D
---
V
P
T
L
L
K
Q
Y
W
R
D
H
S
LHD
L
I
D
P
R
R
----
V
I
S
M
P
L
Y
W
I
T
F
G
Q
-
T
G
T
T
P
L
Y
E
Q
I
K
S
N
Y
I
D
N
S
G
-----------------
N
P
A
Y
G
I
A
A
R
C
E
N
F
N
H
F
I
N
K
V
A
---
V
Q
S
I
P
-----
I
N
G
V
A
------
N
--------------
R
P
V
S
S
T
A
S
Q
L
T
N
Y
K
V
W
R
--
N
P
Y
L
C
---
S
Q
D
P
-------
R
-
D
K
F
---
A
------
P
D
N
L
V
I
E
E
-
D
G
I
Y
R
-
I
D
I
S
G
S
I
N
I
A
N
Y
T
F
PARVG
G
R
Y
F
Q
I
-------
V
C
A
---------
R
N
SSANNLAEFGAE
Q
H
L
P
---------
P
S
G
V
-
W
-----------
T
-----------------
R
-----
R
V
L
V
G
--
E
Y
T
A
G
M
T
E
Q
A
F
S
------------------
S
V
A
T
--------
I
S
-
L
F
KG
D
N
F
F
----
L
Q
-
F
E
T
G
T
---
N
---
T
S
---
R
D
-----------
S
A
Y
N
N
G
Y
G
T
S
G
--
T
-
H
L
R
N
-
F
S
Y
T
L
E
R
V
G
D
-----
L
N
G
T
------------------------
A
Y
Y
D
N
G
T
F-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
67.25
21%
-151
- C6 -
2RH1
6
ADRB2_HUMAN (first)
A:
[42-236]
---------------------------------------
G
M
G
I
V
M
S
L
I
V
L
----------------
A
I
V
F
G
N
V
L
V
I
T
A
I
A
-----------
K
F
E
R
L
Q
-----
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
--
L
A
V
-
V
P
F
G
A
A
H
I
L
M
K
M
W
---
T
F
G
N
F
W
----
C
E
F
W
T
S
I
D
V
L
C
V
T
-
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
-----------------
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
---
I
V
S
G
L
T
S
F
L
P
I
Q
M
-
H
------
W
--------------
Y
R
A
T
----
H
Q
---
E
A
I
N
C
Y
A
-------
E
E
T
C
-------
C
-
D
F
F
---
T
------
N
Q
A
Y
A
I
A
S
-
S
I
V
S
F
-
Y
V
P
L
V
I
M
V
F
V
-----------
Y
S
R
V
-------
F
Q
E
---------
A
---------------
K
R
---------
Q
L
N
I
-
F
-----------
E
-----------------
M
-----
L
R
I
D
E
--
G
L
R
L
K
I
Y
K
D
T
E
G
------------------
Y
Y
T
I
--------
G
I
-
G
H
----
L
L
----
T
K
-
S
P
--
S
---
L
---
N
A
---
A
K
-----------
S
E
L
D
K
A
I
-
G
R
N
--
T
-
N
G
V
I
T
K
D
E
A
E
K
L
F
-
N
-----
Q
D
V
D
A
A
V
R
G
-------------------
I
L
R
N
A
K
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------