@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR1L8_HUMAN: (2016-01-12 )
MERINHTSSVSEFILLGLSSRPEDQKTLFVLFLIVYLVTITGNLLIILAIRFNPHLQTPMYFFLSFLSLTDICFTTSVVPKMLMNFLSEKKTISYAGCLTQMYFLYALGNSDSCLLAVMAFDRYVAVCDPFHYVTTMSHHHCVLLVAFSCSFPHLHSLLHTLLLNRLTFCDSNVIHHFLCDLSPVLKLSCSSIFVNEIVQMTEAPIVLVTRFLCIAFSYIRILTTVLKIPSTSGKRKAFSTCGFYLTVVTLFYGSIFCVYLQPPSTYAVKDHVATIVYTVLSSMLNPFIYSLRNKDLKQGLRKLMSKRS
Atome Classification :
(20 SA)
----------.........10........20-.........30........40........50........60........70.......-.80........90........100.......110...--------....120.......130.......140.......150.......160.......170.......180..-....----.190.......200.......210..-------.....220.----.....---------.230-----------.--------------------...---------..-----.240.......250.......260--------..-.--..-.-.270.......280-----........290.......300.......--------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------MERINH
T
S
S
V
S
E
F
I
L
LGLSS--RPED
Q
K
T
L
F
V
L
F
L
I
V
Y
L
V
T
ITG
N
L
L
I
I
L
A
I
RFNPHLQ
T
P
M
Y
F
F
L
S
F
L
S
L
T
D
I
C
F
T
T
S
V
-
V
P
K
M
L
M
N
F
L
SEKKT
I
S
Y
A
G
C
L
T
Q
M
Y
F
L
Y
A
LGNSD
S
C
L
--------
L
A
V
M
A
FD
R
Y
V
A
VCDP
F
H
Y
V
T
TMSHH
H
C
V
L
L
V
A
FSCS
F
P
H
L
H
S
L
L
H
T
L
L
L
N
R
L
TFC
D
S
N
V
I
H
H
F
L
CD
L
S
P
-
V
L
K
L
----
S
C
S
S
I
F
V
N
E
I
V
Q
MTEA
P
I
V
L
V
T
R
F
L
C
-------
I
A
F
S
Y
I
R
I
L
----
T
T
V
L
K---------IPST-----------S--------------------GKR---------
K
A
-----
F
S
T
C
G
F
Y
L
T
V
V
T
L
F
YG
S
I
F
C
V
Y
LQ--------PP-S--T
Y
-
A
-
V
K
D
H
V
A
T
I
V
Y
T
V
L
------
S
S
M
L
N
P
F
I
Y
S
L
R
N
K
D
L
K
Q
G
L
R
K
L
M
SKRS--------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
83.97
23%
-136
- C2 -
3RFM
1
AA2AR_HUMAN
A:
[14-303]
--------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
--------
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
G
Q
P
--------
G
C
G
E
G
Q
-
V
A
C
L
----
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
-------
L
G
V
-
Y
L
R
I
F
----
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
E
R
A
R
S
T
L
Q
K
E
V
H
A
--------------------
A
K
S
---------
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
--
T
F
F
C
------------
P
D
-
C
--
S
H
-
A
P
L
W
L
M
Y
L
A
I
V
L
A
H
T
------
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
83.97
23%
-137
- C2 -
3PWH
1
?
A:
[14-303]
--------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
--------
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
G
Q
P
--------
G
C
G
E
G
Q
-
V
A
C
L
----
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
-------
L
G
V
-
Y
L
R
I
F
----
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
E
R
A
R
S
T
L
Q
K
E
V
H
A
--------------------
A
K
S
---------
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
--
T
F
F
C
------------
P
D
-
C
--
S
H
-
A
P
L
W
L
M
Y
L
A
I
V
L
A
H
T
------
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
83.83
23%
-137
- C2 -
3UZA
1
AA2AR_HUMAN
A:
[14-303]
--------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
--------
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
G
Q
P
--------
G
C
G
E
G
Q
-
V
A
C
L
----
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
-------
L
G
V
-
Y
L
R
I
F
----
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
E
R
A
R
S
T
L
Q
K
E
V
H
A
--------------------
A
K
S
---------
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
--
T
F
F
C
------------
P
D
-
C
--
S
H
-
A
P
L
W
L
M
Y
L
A
I
V
L
A
H
T
------
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
83.39
23%
-137
- C2 -
3REY
1
AA2AR_HUMAN
A:
[14-303]
--------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
--
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
A
Q
S
S
I
F
S
--------
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
G
Q
P
--------
G
C
G
E
G
Q
-
V
A
C
L
----
F
E
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
-------
L
G
V
-
Y
L
R
I
F
----
A
A
A
R
R
Q
L
K
Q
M
E
S
QP
L
P
G
E
R
A
R
S
T
L
Q
K
E
V
H
A
--------------------
A
K
S
---------
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
--
T
F
F
C
------------
P
D
-
C
--
S
H
-
A
P
L
W
L
M
Y
L
A
I
V
L
A
H
T
------
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
82.18
16%
-134
- C2 -
2Z73
5
OPSD_TODPA
A:
[33-332]
-----------------------------------
V
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
--------
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
W
G
A
Y
---
T
-
L
E
G
V
L
C
N
C
S
F
D
Y
-
I
S
---------
R
D
S
T
T
R
S
N
I
L
C
M
F
I
L
G
F
F
G
P
I
L
I
-------
I
F
F
C
Y
F
N
I
V
----
M
S
V
S
N
---------
H
E
K
E
-----------
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
E
M
---------
R
L
-----
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
V
V
A
L
L
--------
A
Q
F
G
PL
E
W
V
T
-
P
Y
A
A
Q
L
P
V
M
F
A
K
A
------
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------
39
Fugue
82.07
17%
-129
- C2 -
1F88
8
OPSD_BOVIN
A:
[1-348]
MN
G
T
E
G
PNFY
V
P
F
S
N
K
T
G
V
V
R
S
P
F
E
A
P
Q
Y
Y
LA
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
--------
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
-
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
---------------
M
Q
C
----
S
C
G
I
D
Y
Y
T
P
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
Y
G
Q
L
V
----
F
T
V
K
E
---------
A
A
A
S
-----------
A
--------------------
T
T
Q
---------
K
A
-----
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
-
S
--
D
F
-
G
-
P
I
F
M
T
I
P
A
F
F
A
K
T
------
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
NPSTTVSKTETS
Q
V
A
P
A---------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
80.93
23%
-141
- C2 -
2Y04
13
ADRB1_MELGA
A:
[6-300]
---------------------------
L
S
Q
--
Q
W
E
A
G
M
S
L
--
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
--------
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
---
C
T
V
W
A
I
S
A
L
V
S
F
L
----------
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
DP
G
C
C
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
-------
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
---------------------------------------------------S
R
V
M
L
M
R
E
H
K
A
-----
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
------------
V
--
N
V
-
F
-
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
80.90
23%
-142
- C2 -
3ZPQ
11
ADRB1_MELGA
A:
[6-300]
---------------------------
L
S
Q
--
Q
W
E
A
G
M
S
L
--
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
--------
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
---
C
T
V
W
A
I
S
A
L
V
S
F
L
----------
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
DP
G
C
C
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
-------
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
---------------------------------------------------S
R
V
M
L
M
R
E
H
K
A
-----
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
------------
V
--
N
V
-
F
-
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
80.53
23%
-144
- C2 -
2Y02
13
ADRB1_MELGA
A:
[6-300]
---------------------------
L
S
Q
--
Q
W
E
A
G
M
S
L
--
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
--------
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
---
C
T
V
W
A
I
S
A
L
V
S
F
L
----------
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
DP
G
C
C
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
-------
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
---------------------------------------------------S
R
V
M
L
M
R
E
H
K
A
-----
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
------------
V
--
N
V
-
F
-
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
80.51
23%
-139
- C2 -
4AMJ
12
ADRB1_MELGA
A:
[6-300]
---------------------------
L
S
Q
--
Q
W
E
A
G
M
S
L
--
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
--------
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
---
C
T
V
W
A
I
S
A
L
V
S
F
L
----------
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
DP
G
C
C
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
-------
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
---------------------------------------------------S
R
V
M
L
M
R
E
H
K
A
-----
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
------------
V
--
N
V
-
F
-
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
80.49
23%
-139
- C2 -
2Y00
13
ADRB1_MELGA
A:
[6-300]
---------------------------
L
S
Q
--
Q
W
E
A
G
M
S
L
--
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
--------
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
---
C
T
V
W
A
I
S
A
L
V
S
F
L
----------
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
DP
G
C
C
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
-------
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
---------------------------------------------------S
R
V
M
L
M
R
E
H
K
A
-----
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
------------
V
--
N
V
-
F
-
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
80.45
23%
-139
- C2 -
2Y03
9
ADRB1_MELGA
A:
[6-300]
---------------------------
L
S
Q
--
Q
W
E
A
G
M
S
L
--
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
--------
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
---
C
T
V
W
A
I
S
A
L
V
S
F
L
----------
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
DP
G
C
C
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
-------
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
-------------------------------------------------S
R
V
M
L
M
R
E
H
K
A
-----
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
------------
V
--
N
V
-
F
-
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
80.32
23%
-143
- C2 -
3ZPR
11
ADRB1_MELGA
A:
[6-299]
---------------------------
L
S
Q
--
Q
W
E
A
G
M
S
L
--
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
--------
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
---
C
T
V
W
A
I
S
A
L
V
S
F
L
----------
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
DP
G
C
C
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
-------
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
---------------------------------------------------M
L
M
R
E
H
---
K
A
-----
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
------------
V
--
N
V
-
F
-
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
80.21
23%
-140
- C2 -
2Y01
12
ADRB1_MELGA
A:
[6-300]
---------------------------
L
S
Q
--
Q
W
E
A
G
M
S
L
--
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
--------
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
---
C
T
V
W
A
I
S
A
L
V
S
F
L
----------
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
-------
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
---------------------------------------------------S
R
V
M
L
M
R
E
H
K
A
-----
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
------------
V
--
N
V
-
F
-
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
79.22
23%
-143
- C2 -
2YCZ
2
ADRB1_MELGA
A:
[9-298]
--------------------------------
Q
W
E
A
G
M
S
L
--
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
--------
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
---
C
T
V
W
A
I
S
A
L
V
S
F
L
----------
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
DP
G
C
C
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
-------
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
K
---------
I
D
R
A
-----------
S
--------------------
K
R
K
R
V
M
L
M
R
E
H
-
K
A
-----
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
------------
V
--
N
V
-
F
-
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
79.21
23%
-137
- C2 -
2YCW
7
ADRB1_MELGA
A:
[6-298]
---------------------------
L
S
Q
--
Q
W
E
A
G
M
S
L
--
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
--------
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
---
C
T
V
W
A
I
S
A
L
V
S
F
L
----------
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
-------
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
K
---------
I
D
R
A
-----------
S
--------------------
K
R
K
R
V
M
L
M
R
E
H
-
K
A
-----
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
------------
V
--
N
V
-
F
-
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
78.88
23%
-144
- C2 -
2VT4
8
ADRB1_MELGA
A:
[10-298]
---------------------------------
W
E
A
G
M
S
L
--
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
--------
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
---
C
T
V
W
A
I
S
A
L
V
S
F
L
----------
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
DP
G
C
C
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
-------
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
-------------------------------------------------
E
H
-------
K
A
-----
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
------------
V
--
N
V
-
F
-
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
77.88
23%
-138
- C2 -
2YCX
3
ADRB1_MELGA
A:
[9-294]
--------------------------------
Q
W
E
A
G
M
S
L
--
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
--------
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
---
C
T
V
W
A
I
S
A
L
V
S
F
L
----------
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
DP
G
C
C
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
-------
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
K
---------
I
D
R
A
-----------
S
--------------------
K
R
K
R
V
M
L
M
R
E
H
-
K
A
-----
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
------------
V
--
N
V
-
F
-
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
76.88
23%
-145
- C2 -
2YCY
6
ADRB1_MELGA
A:
[10-298]
---------------------------------
W
E
A
G
M
S
L
--
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
--------
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
---
C
T
V
W
A
I
S
A
L
V
S
F
L
----------
P
I
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
DP
G
C
C
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
-------
M
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
-----------
D
R
A
-----------
S
--------------------
K
R
K
R
V
M
L
M
R
E
H
-
K
A
-----
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
------------
V
--
N
V
-
F
-
N
R
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------
42
Fugue
74.41
17%
-115
- C2 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
--------------------------------
D
E
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
M
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
--------
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
----
R
A
T
H
Q
E
A
I
N
C
Y
A
E
E
----
T
----
C
C
D
-
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
-------
M
V
F
V
Y
S
R
V
F
----
Q
E
A
K
R
Q
LN------
I
F
E
M
-----------
L
--------------------
R
I
D
---------
E
G
-----
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
--------
P
S
-
L
--
N
A
-
A
-
K
S
E
L
D
K
A
I
G
R
N
T
N
------
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL