@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR2F1_HUMAN: (2016-01-13 )
MGTDNQTWVSEFILLGLSSDWDTRVSLFVLFLVMYVVTVLGNCLIVLLIRLDSRLHTPMYFFLTNLSLVDVSYATSVVPQLLAHFLAEHKAIPFQSCAAQLFFSLALGGIEFVLLAVMAYDRYVAVCDALRYSAIMHGGLCARLAITSWVSGFISSPVQTAITFQLPMCRNKFIDHISCELLAVVRLACVDTSSNEVTIMVSSIVLLMTPFCLVLLSYIQIISTILKIQSREGRKKAFHTCASHLTVVALCYGVAIFTYIQPHSSPSVLQEKLFSVFYAILTPMLNPMIYSLRNKEVKGAWQKLLWKFSGLTSKLAT
Atome Classification :
(20 SA)
-.........-------------10........20........30........40........50........60........70......-..---80........90........100.....----..110.......120.......130.......140.......150.......160......-----.170.......180.......190-----.........200.......210..----.....220------.......------------.230--------------------...----------....240......---.250----.......260-----......---...270.....----..280.........290.......300.......310.....---------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-MGT
D
N
Q
T
W
V
-------------
S
E
F
I
L
LGLSSD
W
D
T
R
V
S
L
F
V
L
F
L
V
M
Y
V
V
T
V
L
G
N
C
L
I
V
L
L
I
R
LDSRLHT
P
M
Y
F
F
LTN
L
S
L
V
D
V
S
Y
A
T
S
V
-
V
P
---
Q
L
L
A
H
F
L
A
EHKAI
P
F
Q
S
C
A
A
Q
L
F
F
S
L
A
L
----
G
G
I
E
F
V
L
L
A
V
M
A
Y
D
R
Y
V
A
V
C
D
A
L
R
Y
S
A
I
M
HG
G
L
C
A
R
L
A
I
T
S
W
V
S
G
F
I
SSP
V
Q
T
A
I
T
F
QLP
M
-----
C
R
N
K
F
I
D
H
I
S
C
E
L
L
A
V
V
R
L
A
C
V-------DTSS
N
E
V
T
I
M
V
S
S
I
V
L
L
M
T
P
F
C
L
V
----
L
L
S
Y
I
Q
I
-------
I
S
T
I
L
K
I
------------QSRE--------------------
G
R
K
----------
K
A
F
H
T
C
A
S
H
L
T
V
V
---
A
L
C
Y
----
G
V
A
I
F
T
YI-------QPHS
S
P
---
S
V
L
Q
E
K
L
F
S
V
F
----
Y
A
I
--
L
T
P
M
L
N
P
M
I
Y
S
LRN
K
E
V
K
G
A
W
Q
K
L
L
W
K
FSG
L
T
S
KLAT---------
6
PsiBlast_PDB
89.89
25%
-146
- C3 -
2Y00
13
ADRB1_MELGA
A:
[6-299]
------------------------------
L
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
--
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
-----
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
--
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
-------
I
S
A
L
V
S
F
-
L
P
I
-----
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
-------
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
-------
K
E
Q
-------------------------------------------S
R
V
M
L
M
R
E
H
-
K
A
L
K
T
L
G
I
I
M
G
V
F
---
T
L
C
W
----
L
P
F
F
L
V
N
I
-------
V
N
V
F
N
R
---
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
----
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
--------------------
2
PsiBlast_PDB
89.83
25%
-139
- C3 -
2YCW
7
ADRB1_MELGA
A:
[6-297]
------------------------------
L
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
--
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
-----
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
--
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
-------
I
S
A
L
V
S
F
-
L
P
I
-----
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
-------
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
-------
K
E
Q
I
R
K
I
------------
D
R
A
S
--------------------
K
R
K
R
V
M
L
M
R
E
H
--
K
A
L
K
T
L
G
I
I
M
G
V
F
---
T
L
C
W
----
L
P
F
F
L
V
N
I
-------
V
N
V
F
N
R
---
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
----
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
-------------------
7
PsiBlast_PDB
89.44
25%
-144
- C3 -
2Y01
12
ADRB1_MELGA
A:
[6-299]
------------------------------
L
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
--
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
-----
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
--
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
-------
I
S
A
L
V
S
F
-
L
P
I
-----
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
-------
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
-------
K
E
Q
-------------------------------------------S
R
V
M
L
M
R
E
H
-
K
A
L
K
T
L
G
I
I
M
G
V
F
---
T
L
C
W
----
L
P
F
F
L
V
N
I
-------
V
N
V
F
N
R
---
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
----
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
--------------------
12
PsiBlast_PDB
89.05
25%
-141
- C3 -
3ZPQ
11
ADRB1_MELGA
A:
[6-299]
------------------------------
L
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
--
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
-----
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
--
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
-------
I
S
A
L
V
S
F
-
L
P
I
-----
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
-------
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
-------
K
E
Q
-------------------------------------------S
R
V
M
L
M
R
E
H
-
K
A
L
K
T
L
G
I
I
M
G
V
F
---
T
L
C
W
----
L
P
F
F
L
V
N
I
-------
V
N
V
F
N
R
---
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
----
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
--------------------
10
PsiBlast_PDB
89.01
25%
-147
- C3 -
2Y04
13
ADRB1_MELGA
A:
[6-299]
------------------------------
L
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
--
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
-----
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
--
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
-------
I
S
A
L
V
S
F
-
L
P
I
-----
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
-------
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
-------
K
E
Q
-------------------------------------------S
R
V
M
L
M
R
E
H
-
K
A
L
K
T
L
G
I
I
M
G
V
F
---
T
L
C
W
----
L
P
F
F
L
V
N
I
-------
V
N
V
F
N
R
---
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
----
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
--------------------
4
PsiBlast_PDB
88.76
25%
-145
- C3 -
2YCZ
2
ADRB1_MELGA
A:
[9-297]
---------------------------------
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
--
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
-----
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
--
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
-------
I
S
A
L
V
S
F
-
L
P
I
-----
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
-------
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
-------
K
E
Q
I
R
K
I
------------
D
R
A
S
--------------------
K
R
K
R
V
M
L
M
R
E
H
--
K
A
L
K
T
L
G
I
I
M
G
V
F
---
T
L
C
W
----
L
P
F
F
L
V
N
I
-------
V
N
V
F
N
R
---
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
----
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
-------------------
13
PsiBlast_PDB
88.55
25%
-144
- C3 -
3ZPR
11
ADRB1_MELGA
A:
[6-299]
------------------------------
L
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
--
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
-----
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
--
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
-------
I
S
A
L
V
S
F
-
L
P
I
-----
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
-------
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
-------
K
E
Q
-------------------------------------------M
L
M
R
E
H
----
K
A
L
K
T
L
G
I
I
M
G
V
F
---
T
L
C
W
----
L
P
F
F
L
V
N
I
-------
V
N
V
F
N
R
---
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
----
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
---------------------
11
PsiBlast_PDB
88.43
25%
-147
- C3 -
4AMJ
12
ADRB1_MELGA
A:
[6-299]
------------------------------
L
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
--
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
-----
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
--
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
-------
I
S
A
L
V
S
F
-
L
P
I
-----
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
-------
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
-------
K
E
Q
-------------------------------------------S
R
V
M
L
M
R
E
H
-
K
A
L
K
T
L
G
I
I
M
G
V
F
---
T
L
C
W
----
L
P
F
F
L
V
N
I
-------
V
N
V
F
N
R
---
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
----
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
--------------------
8
PsiBlast_PDB
88.18
25%
-147
- C3 -
2Y02
13
ADRB1_MELGA
A:
[6-299]
------------------------------
L
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
--
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
-----
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
--
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
-------
I
S
A
L
V
S
F
-
L
P
I
-----
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
-------
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
-------
K
E
Q
-------------------------------------------S
R
V
M
L
M
R
E
H
-
K
A
L
K
T
L
G
I
I
M
G
V
F
---
T
L
C
W
----
L
P
F
F
L
V
N
I
-------
V
N
V
F
N
R
---
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
----
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
--------------------
9
PsiBlast_PDB
87.77
25%
-147
- C3 -
2Y03
9
ADRB1_MELGA
A:
[6-299]
------------------------------
L
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
--
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
-----
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
--
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
-------
I
S
A
L
V
S
F
-
L
P
I
-----
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
-------
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
-------
K
E
Q
I
R
-----------------------------------------S
R
V
M
L
M
R
E
H
-
K
A
L
K
T
L
G
I
I
M
G
V
F
---
T
L
C
W
----
L
P
F
F
L
V
N
I
-------
V
N
V
F
N
R
---
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
----
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
--------------------
15
PsiBlast_PDB
87.51
24%
-146
- C3 -
4BVN
11
ADRB1_MELGA
A:
[6-299]
------------------------------
L
S
Q
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
--
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
-----
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
V
E
--
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
-------
I
S
A
L
V
S
F
-
L
P
I
-----
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
-------
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
-------
K
E
Q
I
R
--------------------------------------
K
R
K
TS
R
V
M
L
M
R
E
H
K
A
L
K
T
L
G
I
I
M
G
V
F
---
T
L
C
W
----
L
P
F
F
L
V
N
I
-------
V
N
V
F
N
R
---
D
L
V
P
K
W
L
F
V
A
F
N
W
L
G
Y
A
----
N
S
A
M
N
P
I
I
L
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
--------------------
1
PsiBlast_PDB
87.20
25%
-148
- C3 -
2VT4
8
ADRB1_MELGA
A:
[10-297]
----------------------------------
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
--
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
-----
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
--
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
-------
I
S
A
L
V
S
F
-
L
P
I
-----
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
-------
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
-------
K
E
Q
I
R
-----------------------------------------
E
H
--------
K
A
L
K
T
L
G
I
I
M
G
V
F
---
T
L
C
W
----
L
P
F
F
L
V
N
I
-------
V
N
V
F
N
R
---
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
----
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
--------------------
5
PsiBlast_PDB
87.05
25%
-148
- C3 -
2YCY
6
ADRB1_MELGA
A:
[10-297]
----------------------------------
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
--
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
-----
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
--
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
-------
I
S
A
L
V
S
F
-
L
P
I
-----
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
-------
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
-------
K
E
Q
I
R
--------------
D
R
A
S
--------------------
K
R
K
R
V
M
L
M
R
E
H
--
K
A
L
K
T
L
G
I
I
M
G
V
F
---
T
L
C
W
----
L
P
F
F
L
V
N
I
-------
V
N
V
F
N
R
---
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
----
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
-------------------
3
PsiBlast_PDB
86.98
25%
-142
- C3 -
2YCX
3
ADRB1_MELGA
A:
[9-294]
---------------------------------
Q
W
E
A
G
M
S
L
L
M
A
L
V
V
L
L
I
V
A
--
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
-----
F
G
A
T
L
V
V
R
G
T
W
L
W
G
S
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
--
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
-------
I
S
A
L
V
S
F
-
L
P
I
-----
M
M
H
W
W
R
D
E
D
P
Q
A
L
K
C
Y
Q
D
P
G
C
C
-------
D
F
V
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
L
R
V
Y
R
E
A
-------
K
E
Q
I
R
K
I
------------
D
R
A
S
--------------------
K
R
K
R
V
M
L
M
R
E
H
--
K
A
L
K
T
L
G
I
I
M
G
V
F
---
T
L
C
W
----
L
P
F
F
L
V
N
I
-------
V
N
V
F
N
R
---
D
L
V
P
D
W
L
F
V
A
F
N
W
L
G
Y
A
----
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
------------------------
41
Fugue
86.82
18%
-132
- C3 -
1F88
8
OPSD_BOVIN
A:
[1-348]
M
N
G
T
E
G
P
N
F
Y
VPFSNKTGVVRSP
F
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
-
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
---
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
----
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
-----
G
---------------
M
Q
C
S
C
G
I
DYYTPH
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
----
F
F
C
Y
G
Q
L
-------
V
F
T
V
K
E
A
------------
A
A
S
A
--------------------
T
T
Q
----------
K
A
E
K
E
V
T
R
M
V
I
I
M
---
V
I
A
F
----
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
D
---
F
G
P
I
F
M
T
I
P
A
F
----
F
A
K
--
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
S
T
T
V
S
K
TETS
Q
V
A
P
A
20
PsiBlast_PDB
86.40
22%
-149
- C3 -
3REY
1
AA2AR_HUMAN
A:
[14-303]
---------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
-----
F
V
L
V
L
----
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
-------
A
I
G
L
T
-
P
M
LGWNN
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
L
F
E
-----
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
----
L
G
V
Y
L
R
I
-------
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QPLPGE
R
A
R
S
--------------------
T
L
Q
----------
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
-------
C
P
D
C
S
H
---
A
P
L
W
L
M
Y
L
A
I
V
----
L
A
H
--
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------------
19
PsiBlast_PDB
84.39
22%
-146
- C3 -
3PWH
1
?
A:
[14-303]
---------------------------------------------
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
V
L
A
-
I
P
F
A
I
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
-----
F
V
L
V
L
----
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
-------
A
I
G
L
T
-
P
M
LGWNN
C
G
Q
P
--------
G
C
G
E
G
Q
V
A
C
L
FE-----
D
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
L
L
L
M
----
L
G
V
Y
L
R
I
-------
F
A
A
A
R
R
Q
L
K
Q
M
E
S
QPLPGE
R
A
R
S
--------------------
T
L
Q
----------
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
-------
C
P
D
C
S
H
---
A
P
L
W
L
M
Y
L
A
I
V
----
L
A
H
--
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-------------------
34
HHSearch
82.61
15%
-135
- C3 -
2Z73
5
OPSD_TODPA
A:
[32-333]
-----------------------------------
A
V
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
---
L
M
T
I
S
C
F
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
----
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
G
W
G
A
Y
T
L
---------
E
G
V
L
C
N
C
S
F
D
Y
I
S
------------
R
D
S
T
T
R
S
N
I
L
C
M
F
I
L
G
F
F
G
P
I
L
I
I
----
F
F
C
Y
F
N
I
-------
V
M
S
V
S
N
H
------------
E
K
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
E
M
----------
R
L
A
K
I
S
I
V
I
V
S
Q
F
---
L
L
S
W
----
S
P
Y
A
V
V
A
L
-------
L
A
Q
F
G
P
LEW
V
T
P
Y
A
A
Q
L
P
V
M
----
F
A
K
--
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
Q
F
D
D
K
---------
17
PsiBlast_PDB
81.37
22%
-148
- C3 -
4LDL
3
ADRB2_HUMAN
A:
[183-461]
--------------------------------------
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
---
F
G
A
A
H
I
L
T
--
K
T
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
--
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
----
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
-----
Y
R
A
T
H
Q
E
A
I
N
C
----
Y
A
E
E
T
C
C
-------
D
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
----
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
Q
---
K
F
------------
A
L
K
E
----------------------
H
----------
K
A
L
K
T
L
G
I
I
M
G
T
F
---
T
L
C
W
----
L
P
F
F
I
V
N
I
-------
V
H
V
I
Q
D
---
N
L
I
R
K
E
V
Y
I
L
L
----
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
-------------------
18
PsiBlast_PDB
81.15
22%
-149
- C3 -
4LDO
3
A:
[183-461]
--------------------------------------
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
---
F
G
A
A
H
I
L
T
--
K
T
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
--
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
----
I
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
-----
Y
R
A
T
H
Q
E
A
I
N
C
----
Y
A
E
E
T
C
C
-------
D
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
----
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
L
Q
---
K
F
------------
A
L
K
E
----------------------
H
----------
K
A
L
K
T
L
G
I
I
M
G
T
F
---
T
L
C
W
----
L
P
F
F
I
V
N
I
-------
V
H
V
I
Q
D
---
N
L
I
R
K
E
V
Y
I
L
L
----
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
-------------------