@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR4A4_HUMAN: (2016-01-13 )
MEPRKNVTDFVLLGFTQNPKEQKVLFVMFLLFYILTMVGNLLIVVTVTVSETLGSPMSFFLAGLTFIDIIYSSSISPRLISDLFFGNNSISFQSFMAQLFIEHLFGGSEVFLLLVMAYDRYVAICKPLHYLVIMRQWVCVLLLVVSWVGGFLQSVFQLSIIYGLPFCGPNVIDHFFCDMYPLLKLACTDTHVIGLLVVANGGLSCTIAFLLLLISYGVILHSLKKLSQKGRQKAHSTCSSHITVVVFFFVPCIFMCARPARTFSIDKSVSVFYTVITPMLNPLIYTLRNSEMTSAMKKL
Atome Classification :
(20 SA)
---------.........10....--..---------------..20........30........---40........50........60........70----.....-....80........90.......--.100.......110--.......120...----------...--------.130----------------......----.140-----........150.......-----160--.....-....170.......180..--.....190.------......200.......210....----....220.......------------230-------------------.-----..---------------...-...240.......250--------.-....-----------..260-.--.------.-.-------------.---.----.---------..270.......280.......-290.......----------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------MEPRKNV
T
D
F
V
L
L
GF--TQ---------------NPK
E
Q
K
V
L
F
V
M
F
L
L
F
Y
I
L
T
M
VG---
N
L
L
I
V
V
T
V
T
V
S
E
TLG
S
P
M
S
F
F
L
A
G
L
T
F
I
D
I
I
-----YSSSI-
S
P
R
L
I
S
D
L
FFGNNSI
S
F
Q
S
F
M
A
Q
--
L
F
I
E
H
LFG
G
S
E
V
F
L
--
L
L
V
M
A
Y
D
R
Y
V
A
I
C
----------
K
P
L
--------
H
Y
L
V
----------------
I
M
R
Q
W
V
----
C
V
L
------
L
L
V
V
S
W
V
G
G
F
L
Q
S
V
F
Q
L
S
-----
I
----
I
YGLP-FC
G
P
N
V
I
D
H
F
F
C
D
M
Y
P
L
L
K
--LACTD
T
H
V
I
------
G
L
L
V
V
ANG
G
L
S
C
T
I
A
F
L
-
L
L
L
I
S
----
Y
G
V
I
L
H
S
L
K
K
L
S
Q
K
------------
G
---------------------
R
-----
Q
K
---------------
A
H
S
-
T
C
SS
H
I
T
V
V
V
F
F
F
V
P
C
--------
I
-
F
M
CA-----------RPA---
R
--
T
------
F
-S-------------I---D----K---------S
V
S
V
F
Y
T
V
I
T
P
M
L
N
P
L
I
Y
T
LR
N
-
S
E
M
T
S
A
M
KKL----------------------------
5
PsiBlast_PDB
90.32
22%
-158
- C2 -
4ZWJ
-
?
A:
[204-477]
-----------------------------------------------------
M
F
L
L
I
V
L
G
F
P
I
N
---
F
L
T
L
Y
V
T
V
Q
-
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
L
GG
F
T
S
T
L
-
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
Q
G
F
F
A
T
--
L
-------
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
----------
K
P
M
SNFRFG
E
N
H
A
I
M
G
---------------
V
A
F
T
W
V
----
M
A
L
------
A
C
A
A
P
P
L
A
G
W
S
R
Y
I
P
E
--------------
G
L
Q
C
S
C
G
--------
I
D
Y
Y
T
L
K
P
--
E
V
N
N
E
S
F
V
I
------
Y
M
F
V
V
-----
H
F
T
I
P
M
I
-
I
I
F
F
C
----
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
------------
Q
---------------------
Q
-----
E
S
---------------
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
Y
V
I
A
--------
F
-
L
I
C
W
-----------
V
P
Y
---
A
--
S
------
V
-
A
F
Y
I
F
T
H
QG
S
C
F
G
P
I
---
F
----
M
---------
T
I
P
A
F
F
A
K
S
A
A
I
Y
N
P
V
I
Y
I
M
M
N
-
K
Q
F
R
N
C
M
L
T
T
----------------------------
39
Fugue
88.93
20%
-135
- C2 -
1F88
8
OPSD_BOVIN
A:
[1-348]
---------
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
--
K
T
GVVRSPFEAPQYYLA
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
---
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
-----
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
--
G
F
F
A
T
L
G
G
E
I
A
L
W
S
--
L
V
V
L
A
I
E
R
Y
V
V
V
C
----------
K
P
M
--------
S
N
F
R
-----------------
F
G
E
N
H
----
A
I
M
------
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
GW
S
R
Y
I
----
P
E
G
M
Q
C
S
C
G
I
--------
D
Y
Y
T
P
H
E
--
E
T
N
N
E
S
F
V
I
------
Y
M
F
V
V
H
-----
F
I
I
P
L
I
-
V
I
F
F
C
----
Y
G
Q
L
V
F
T
V
K
E
A
A
A
S
------------
A
T--------------------
T
-----
Q
K
---------------
A
E
K
-
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
--------
W
-
L
P
Y
A
-----------
G
V
A
---
F
--
Y
------
I
-
F
-------------
T
---
H
----
Q
GSDFGPIFM
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
-
K
Q
F
R
N
C
M
V
T
T
L
C
CGKNPSTTVSKTETS
Q
V
A
P
A------
34
HHSearch
84.87
15%
-146
- C2 -
2Z73
5
OPSD_TODPA
A:
[33-329]
----------------------------------------------
V
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
---
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
-----
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
L
K
K
W
I
F
G
F
A
A
C
K
V
Y
--
G
F
I
G
G
I
F
G
F
M
S
I
M
T
--
M
A
M
I
S
I
D
R
Y
N
V
I
G
----------
R
P
M
--------
A
A
S
K
----------------
K
M
S
H
R
R
----
A
F
I
------
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
P
I
F
-----
G
----
W
G
A
Y
T
-----
L
E
G
V
L
C
N
C
S
F
D
Y
I
S
R
--
D
----
S
-
T
T
------
R
S
N
I
L
C
M
F
I
L
G
F
F
G
P
I
L
-
I
I
F
F
C
----
Y
F
N
I
V
M
S
V
S
N
H
E
K
E
------------
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
E
-----
M
R
---------------
L
A
K
-
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
--------
A
-
V
V
A
L
-----------
L
A
Q
---
F
--
G
PLEW--
V
T
P
-------------
Y
---
A
----
A
---------
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
-
P
K
F
R
E
A
I
S
Q
T
----------------------------
15
PsiBlast_PDB
84.58
20%
-157
- C2 -
3PQR
9
OPSD_BOVIN
A:
[45-317]
----------------------------------------------------------
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
FGG
F
T
T
T
L
-
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
--
L
-------
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
----------
K
P
M
SN
F
R
F
G
E
N
H
A
I
M
G
---------------
V
A
F
T
W
V
M
A
L
A
C
A
A
------
P
P
L
V
G
W
-
S
R
Y
I
P
E
G
M
Q
C
S
-----------------
C
G
--------
I
D
Y
Y
T
P
H
E
--
E
T
N
N
E
S
F
V
I
------
Y
M
F
V
V
-----
H
F
I
I
P
L
I
-
V
I
F
F
C
----
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
------------
Q
---------------------
Q
ES
A
T
T
Q
K
---------------
A
E
K
-
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
-
Y
I
F
T
-----------
H
Q
G
---
S
--
D
------
F
-
G
P
------------
I
---
F
----
M
---------
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
-
K
Q
F
R
N
C
M
V
T
T
----------------------------
17
PsiBlast_PDB
84.24
20%
-154
- C2 -
4J4Q
8
GNAT1_BOVIN (first)
A:
[45-317]
----------------------------------------------------------
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
GG
F
T
T
T
L
-
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
--
L
-------
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
----------
K
P
M
SNFRFG
E
N
H
A
I
M
G
---------------
V
A
F
T
W
V
M
A
L
A
C
A
A
------
P
P
L
V
G
W
-
S
R
Y
I
P
E
G
M
Q
C
S
-----------------
C
G
--------
I
D
Y
Y
T
P
H
E
--
E
T
N
N
E
S
F
V
I
------
Y
M
F
V
V
-----
H
F
I
I
P
L
I
-
V
I
F
F
C
----
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
------------
Q
---------------------
Q
ES
A
T
T
Q
K
---------------
A
E
K
-
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
-
Y
I
F
T
-----------
H
Q
G
---
S
--
D
------
F
-
G
P
------------
I
---
F
----
M
---------
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
-
K
Q
F
R
N
C
M
V
T
T
----------------------------
14
PsiBlast_PDB
84.19
20%
-152
- C2 -
3DQB
4
GNAT1_BOVIN (first)
A:
[45-317]
----------------------------------------------------------
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
GG
F
T
T
T
L
-
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
--
L
-------
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
----------
K
P
M
SNFRFG
E
N
H
A
I
M
G
---------------
V
A
F
T
W
V
M
A
L
A
C
A
A
------
P
P
L
V
G
W
-
S
R
Y
I
P
E
G
M
Q
C
S
-----------------
C
G
--------
I
D
Y
Y
T
P
H
E
--
E
T
N
N
E
S
F
V
I
------
Y
M
F
V
V
-----
H
F
I
I
P
L
I
-
V
I
F
F
C
----
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
------------
Q
---------------------
Q
ES
A
T
T
Q
K
---------------
A
E
K
-
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
-
Y
I
F
T
-----------
H
Q
G
---
S
--
D
------
F
-
G
P
------------
I
---
F
----
M
---------
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
-
K
Q
F
R
N
C
M
V
T
T
----------------------------
12
PsiBlast_PDB
83.79
20%
-149
- C2 -
3C9L
13
OPSD_BOVIN
A:
[45-317]
----------------------------------------------------------
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
-
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
--
L
-------
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
----------
K
P
M
SNFRFG
E
N
H
A
I
M
G
---------------
V
A
F
T
W
V
M
A
L
A
C
A
A
------
P
P
L
V
G
W
-
S
R
Y
I
P
E
G
M
Q
C
S
-----------------
C
G
--------
I
D
Y
Y
T
P
H
E
--
E
T
N
N
E
S
F
V
I
------
Y
M
F
V
V
-----
H
F
I
I
P
L
I
-
V
I
F
F
C
----
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
------------
Q
---------------------
Q
ES
A
T
T
Q
K
---------------
A
E
K
-
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
-
Y
I
F
T
-----------
H
Q
G
---
S
--
D
------
F
-
G
P------------
I
---
F
----
M
---------
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
-
K
Q
F
R
N
C
M
V
T
T
----------------------------
13
PsiBlast_PDB
82.95
20%
-145
- C2 -
1F88
7
OPSD_BOVIN
A:
[45-317]
----------------------------------------------------------
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
GG
F
T
T
T
L
-
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
--
L
-------
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
----------
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
---------------
V
A
F
T
W
V
M
A
L
A
C
A
A
------
P
P
L
V
G
W
-
S
R
Y
I
P
E
G
M
Q
C
S
-----------------
C
G
--------
I
D
Y
Y
T
P
H
E
--
E
T
N
N
E
S
F
V
I
------
Y
M
F
V
V
-----
H
F
I
I
P
L
I
-
V
I
F
F
C
----
Y
G
Q
L
V
F
T
V
K
E
A
A
A
------------------------------------SATT-
Q
K
---------------
A
E
K
-
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
-
Y
I
F
T
-----------
H
Q
G
---
S
--
D
------
F
-
G
P------------
I
---
F
----
M
---------
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
-
K
Q
F
R
N
C
M
V
T
T
----------------------------
11
PsiBlast_PDB
82.74
20%
-156
- C2 -
3CAP
4
OPSD_BOVIN
A:
[45-317]
----------------------------------------------------------
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
GG
F
T
T
T
L
-
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
--
L
-------
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
----------
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
---------------
V
A
F
T
W
V
M
A
L
A
C
A
A
------
P
P
L
V
G
W
-
S
R
Y
I
P
E
G
M
Q
C
S
-----------------
C
G
--------
I
D
Y
Y
T
P
H
E
--
E
T
N
N
E
S
F
V
I
------
Y
M
F
V
V
-----
H
F
I
I
P
L
I
-
V
I
F
F
C
----
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
------------
Q
---------------------
Q
ES
A
T
T
Q
K
---------------
A
E
K
-
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
-
Y
I
F
T
-----------
H
Q
G
---
S
--
D
------
F
-
G
P
------------
I
---
F
----
M
---------
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
-
K
Q
F
R
N
C
M
V
T
T
----------------------------
16
PsiBlast_PDB
82.68
20%
-153
- C2 -
3PXO
4
OPSD_BOVIN
A:
[45-317]
----------------------------------------------------------
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
-
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
--
L
-------
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
----------
K
P
M
SN
F
R
F
G
E
N
H
A
I
M
G
---------------
V
A
F
T
W
V
M
A
L
A
C
A
A
------
P
P
L
V
G
W
-
S
R
Y
I
P
E
G
M
Q
C
S
-----------------
C
G
--------
I
D
Y
Y
T
P
H
E
--
E
T
N
N
E
S
F
V
I
------
Y
M
F
V
V
-----
H
F
I
I
P
L
I
-
V
I
F
F
C
----
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
------------
Q
---------------------
Q
ES
A
T
T
Q
K
---------------
A
E
K
-
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
-
Y
I
F
T
-----------
H
Q
G
---
S
--
D
------
F
-
G
P
------------
I
---
F
----
M
---------
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
-
K
Q
F
R
N
C
M
V
T
T
----------------------------
18
PsiBlast_PDB
82.39
20%
-154
- C2 -
4PXF
7
OPSD_BOVIN
A:
[45-317]
----------------------------------------------------------
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
-
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
--
L
-------
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
----------
K
P
M
SNFRFG
E
N
H
A
I
M
G
---------------
V
A
F
T
W
V
M
A
L
A
C
A
A
------
P
P
L
V
G
W
-
S
R
Y
I
P
E
G
M
Q
C
S
-----------------
C
G
--------
I
D
Y
Y
T
P
H
E
--
E
T
N
N
E
S
F
V
I
------
Y
M
F
V
V
-----
H
F
I
I
P
L
I
-
V
I
F
F
C
----
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
------------
Q
---------------------
Q
ES
A
T
T
Q
K
---------------
A
E
K
-
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
-
Y
I
F
T
-----------
H
Q
G
---
S
--
D
------
F
-
G
P
------------
I
---
F
----
M
---------
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
-
K
Q
F
R
N
C
M
V
T
T
----------------------------
40
Fugue
81.94
20%
-123
- C2 -
1U19
15
OPSD_BOVIN
A:
[4-349]
---------
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
--
K
T
GVVRSPFEAPQYYLA
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
---
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
-----
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
--
G
F
F
A
T
L
G
G
E
I
A
L
W
S
--
L
V
V
L
A
I
E
R
Y
V
V
V
C
----------
K
P
M
--------
S
N
F
R
-----------------
F
G
E
N
H
----
A
I
M
------
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
GW
S
R
Y
I
----
P
E
G
M
Q
C
S
C
G
I
--------
D
Y
Y
T
P
H
E
--
E
T
N
N
E
S
F
V
I
------
Y
M
F
V
V
H
F
-----
I
I
P
L
I
-
V
I
F
F
C
----
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
QQESA-------
T
---------------------
T
-----
Q
K
---------------
A
E
K
-
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
--------
W
-
L
P
Y
A
-----------
G
V
A
---
F
--
Y
------
I
-
F
-------------
T
---
H
----
Q
GSDFGPIFM
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
-
K
Q
F
R
N
C
M
V
T
T
L
C
CGKNPLGDDEA
S
T
T
V
S
K
TETSQVAPA
6
PsiBlast_PDB
80.15
20%
-125
- C2 -
4A4M
4
OPSD_BOVIN
A:
[48-318]
----------------------------------------------------------
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
GG
F
T
T
T
L
-
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
--
L
-------
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
----------
K
P
M
SN
F
R
F
G
E
N
H
A
I
M
G
---------------
V
A
F
T
W
V
M
A
L
A
C
A
A
------
P
P
L
V
G
W
-
S
R
Y
I
P
E
G
M
Q
C
S
-----------------
C
G
--------
I
D
Y
Y
T
P
H
E
--
E
T
N
N
E
S
F
V
I
------
Y
M
F
V
V
-----
H
F
I
I
P
L
I
-
V
I
F
F
C
----
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
------------
Q
---------------------
Q
-----
E
S
---------------
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
Y
V
I
A
--------
F
-
L
I
C
W
-----------
L
P
Y
---
A
--
G
------
V
-
A
F
Y
I
F
T
H
QG
S
C
F
G
P
I
---
F
----
M
---------
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
-
K
Q
F
R
N
C
M
V
T
T
----------------------------
20
PsiBlast_PDB
77.45
20%
-118
- C2 -
1GZM
15
OPSD_BOVIN
A:
[48-318]
----------------------------------------------------------
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
L
-
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
--
L
-------
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
----------
K
P
M
SNFRFG
E
N
H
A
I
M
G
---------------
V
A
F
T
W
V
M
A
L
A
C
A
A
------
P
P
L
V
G
W
-
S
R
Y
I
P
E
G
M
Q
C
S
-----------------
C
G
--------
I
D
Y
Y
T
P
H
E
--
E
T
N
N
E
S
F
V
I
------
Y
M
F
V
V
-----
H
F
I
I
P
L
I
-
V
I
F
F
C
----
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
------------
Q
---------------------
Q
ES
A
T
T
Q
K
---------------
A
E
K
-
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
-
Y
I
F
T
-----------
H
Q
G
---
S
--
D
------
F
-
G
P------------
I
---
F
----
M
---------
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
-
K
Q
F
R
N
C
M
V
T
T
----------------------------
19
PsiBlast_PDB
76.83
20%
-119
- C2 -
3OAX
16
OPSD_BOVIN
A:
[48-318]
----------------------------------------------------------
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
GG
F
T
T
T
L
-
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
--
L
-------
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
----------
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
---------------
V
A
F
T
W
V
M
A
L
A
C
A
A
------
P
P
L
V
G
W
-
S
R
Y
I
P
E
G
M
Q
C
S
-----------------
C
G
--------
I
D
Y
Y
T
P
H
E
--
E
T
N
N
E
S
F
V
I
------
Y
M
F
V
V
-----
H
F
I
I
P
L
I
-
V
I
F
F
C
----
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
------------
Q
---------------------
Q
ESA
T
T
Q
K
---------------
A
E
K
-
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
-
Y
I
F
T
-----------
H
Q
G
---
S
--
D
------
F
-
G
P------------
I
---
F
----
M
---------
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
-
K
Q
F
R
N
C
M
V
T
T
----------------------------
7
PsiBlast_PDB
76.48
20%
-128
- C2 -
2X72
5
GNAT1_BOVIN (first)
A:
[48-318]
----------------------------------------------------------
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
GG
F
T
T
T
L
-
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
Q
G
F
F
A
T
--
L
-------
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
----------
K
P
M
SN
F
R
F
G
E
N
H
A
I
M
G
---------------
V
A
F
T
W
V
M
A
L
A
C
A
A
------
P
P
L
V
G
W
-
S
R
Y
I
P
E
G
M
Q
C
S
-----------------
C
G
--------
I
D
Y
Y
T
P
H
E
--
E
T
N
N
E
S
F
V
I
------
Y
M
F
V
V
-----
H
F
I
I
P
L
I
-
V
I
F
F
C
----
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
------------
Q
---------------------
Q
-----
E
S
---------------
A
T
T
Q
K
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
--------
F
-
L
I
C
W
-----------
L
P
Y
---
A
--
G
------
V
-
A
F
Y
I
F
T
H
QG
S
C
F
G
P
I
---
F
----
M
---------
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
-
K
Q
F
R
N
C
M
V
T
T
----------------------------
48
Fugue
76.42
20%
-166
- C1 -
4Q9T
-
?
A:
[12-446]
TKILTETEK
Y
S
V
T
K
L
S
T
D
L
S
F
L
P
F
E
G
L
V
---------------
D
T
A
L
Q
K
A
L
V
N
D
L
D
H
I
Y
I
W
N
Y
N
S
---
I
Q
K
D
T
P
I
C
K
I
S
L
H
S
S
P
P
I
C
L
F
T
S
S
I
N
G
I
C
I
I
-----
N
K
K
N
S
-
Q
F
L
Y
F
E
D
I
S
T
I
N
N
L
A
H
V
L
D
L
K
L
K
DN
E
N
I
T
S
T
I
N
C
E
P
S
G
I
--
I
I
A
T
S
L
G
R
V
L
F
I
T
IKDSTGK
P
K
L
E
L
K
--------
Q
Q
L
I
KPQNSFFFRNLDSSKE
I
I
S
L
K
K
----
G
P
I
V
G
KG
E
R
L
L
Y
I
T
T
R
G
G
S
L
Q
-
I
W
Q
L
S
-----
I
N
S
K
S
F
K
R
L
E
-
I
N
I
Y
E
H
V
L
D
S
L
Q
D
L
Y
P
F
A
H
GT
L
A
F
L
D
S
H
P
I
YSDTSS
A
H
L
T
L
A
S
I
S
N
G
N
E
I
Y
Y
L
M
I
T
V
I
L
D
EKT
N
S
F
Q
I
F
S
I
Y
K
L
N
T
Y
------------
F
---------------------
T
-----
K
S
TVDLNH
K
P
Q
L
F
I
PNA
L
D
S
-
I
V
S
P
T
L
S
V
Y
V
L
F
N
N
A
V
--------
V
M
T
Q
I
S
SKLDSSFPLRR
K
W
E
---
D
--
I
------
I
-
R
-------------
F
---
N
----
K
---------
D
V
E
I
I
G
S
G
Y
S
T
--
D
S
I
Y
V
I
C
K
D
M
G
V
L
K
I
A
S
H
------------------------------
29
HHSearch
76.01
14%
-135
* C2 *
2KS9
1
NK1R_HUMAN
A:
[35-319]
--------------------------------------------------
W
A
A
A
Y
T
V
I
V
V
T
S
V
V
G
---
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
-----
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
H
N
E
W
Y
Y
G
L
F
Y
C
K
F
H
--
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
--
M
T
A
V
A
F
D
R
Y
M
A
I
I
----------
H
P
L
--------
Q
P
R
L
------------------
S
A
T
A
----
T
K
V
------
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
Q
G
Y
-----
Y
----
S
T
T
-
E
-----
T
M
P
S
R
V
V
C
M
I
E
W
P
E
H
--
P
N
--
K
I
Y
E
-------
K
V
Y
H
I
C
V
T
V
L
I
Y
F
L
P
L
L
-
V
I
G
Y
A
----
Y
T
V
V
G
I
T
L
W
A
S
E
I
P
GDSSDRYH
E
Q
V
S
A
---------------------
K
-----
R
K
---------------
V
V
K
-
M
M
I
V
V
V
C
T
F
A
I
C
W
L
P
F
--------
H
-
I
F
F
L
-----------
L
P
Y
I
NP
D
--
L
Y-----
L
-
K
K------------
F
I
Q
Q
V
----
Y
---------
L
A
I
M
W
L
A
M
S
S
T
M
Y
N
P
I
I
Y
C
C
L
N
-
D
R
F
R
L
G
F
K
H
A
----------------------------
32
HHSearch
75.49
16%
-140
- C2 -
1U19
13
OPSD_BOVIN
A:
[39-320]
----------------------------------------------
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
---
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
-----
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
--
G
F
F
A
T
L
G
G
E
I
A
L
W
S
--
L
V
V
L
A
I
E
R
Y
V
V
V
C
----------
K
P
M
--------
S
N
F
R
-----------------
F
G
E
N
H
----
A
I
M
------
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
-----
G
----
W
S
R
Y
I
-----
P
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
--
H
E
--
E
T
N
N
-------
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
-
V
I
F
F
C
----
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
------------
Q
QESA
T
T
Q
K
A
------------
E
-----
K
E
---------------
V
T
R
-
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
--------
A
-
G
V
A
F
-----------
Y
I
F
T
H
-
Q
GS
D
------
F
-
G
P------------
I
---
F
----
M
---------
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
-
K
Q
F
R
N
C
M
V
T
T
----------------------------
28
HHSearch
74.52
15%
-129
- C2 -
2LNL
-
CXCR1_HUMAN
A:
[39-319]
-----------------------------------------------
K
Y
V
V
I
I
A
Y
A
L
V
F
L
L
S
L
L
G
---
N
S
L
V
M
L
V
I
L
Y
S
R
V
G
R
S
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
-----
F
A
L
-
T
-
L
P
I
W
A
A
S
K
-
V
N
G
W
I
F
G
T
F
L
C
K
V
V
--
S
L
L
K
E
V
N
F
Y
S
G
I
L
L
--
L
A
C
I
S
V
D
R
Y
L
A
I
V
----------
H
A
T
--------
R
T
L
T
-----------------
Q
K
R
H
L
----
V
K
F
------
V
C
L
G
C
W
G
L
S
M
N
L
S
L
P
F
F
L
-----
F
----
R
Q
A
Y
H
-----
P
N
N
S
S
P
V
C
Y
E
V
L
G
N
D
--
T
---
A
K
W
R
-------
M
V
L
R
I
L
P
H
T
F
G
F
I
V
P
L
F
-
V
M
L
F
C
----
Y
G
F
T
L
R
T
L
F
K
A
H
M
G
------------
Q
---------------------
K
-----
H
R
---------------
A
M
R
-
V
I
F
A
V
V
L
I
F
L
L
C
W
L
P
Y
--------
N
-
L
V
L
L
-----------
A
D
T
L
M
-
R
TQ
V
IQE
S
C
E
R
-
R
-------------
N
---
N
I
G
R
A
L
---------
D
A
T
E
I
L
G
F
L
H
S
C
L
N
P
I
I
Y
A
F
I
G
-
Q
N
F
R
H
G
F
L
K
I
----------------------------