@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR4C6_HUMAN: (2016-01-13 )
MENQNNVTEFILLGLTENLELWKIFSAVFLVMYVATVLENLLIVVTIITSQSLRSPMYFFLTFLSLLDVMFSSVVAPKVIVDTLSKSTTISLKGCLTQLFVEHFFGGVGIILLTVMAYDRYVAICKPLHYTIIMSPRVCCLMVGGAWVGGFMHAMIQLLFMYQIPFCGPNIIDHFICDLFQLLTLACTDTHILGLLVTLNSGMMCVAIFLILIASYTVILCSLKSYSSKGRHKALSTCSSHLTVVVLFFVPCIFLYMRPVVTHPIDKAMAVSDSIITPMLNPLIYTLRNAEVKSAMKKLWMKWEALAGK
Atome Classification :
(20 SA)
---------------------------.........10...-...---------------..---20........30.----...--....40.....--...50.-.......60........70.-...-..-..--80...-.....90.-.......100-......-..110...-..--..120..--.....130.---......----140.------...---------.---.-.--150.......-160-----------------------...-------.-----.---.-..170....--...180......-.190-.....------...-200...-....210-.--.....-------..--220--....-...------------230-------------------.------------------..----...---...240.......-----------..250.......260--.-------.-----.-..----.---------..270-.-----------------...-.....280-.-......-..290---.......300.......------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------------------------MENQN
N
V
T
E
F
I
L
LG-LTE---------------N
L
---
E
L
W
K
I
F
S
A
V
F
L
V
M
----
Y
V
A
--
T
V
L
EN
L
L
I
V
V
T
--
I
IT
S
Q
S
-LR
S
P
M
Y
F
F
L
T
F
L
S
L
L
D
V
M
F
S
-SVV-A
P
-
K
V
--
I
V
D
TL-SKS
T
T
I
S
L
-
K
G
C
L
T
Q
L
F
V
--
E
H
F
FG
G
-
V
G
I
I
L
L
T
V
-
M
A
--YD
R
Y
V
A
I
--CK
P
L
H
Y
T
I
I
---MSP
R
V
C
----
C
L
M
V------G
G
A
---------
W
---
V
-
G
--
G
F
M
H
A
M
I
Q
L
L
-
F
M
------------------------YQI-------P-----F---C-
G
P
N
I
I
D
H
F
I
--
C
D
L
F
Q
L
L
T
L
ACT-DT-
H
-
I
L
G
L
L
------
V
TL-NS
G
M
M
C
-
V
A
I
F
L
-
I
-
L
--
I
A
S
Y
T
-------
V
I
--
L
C
S--
L
K
SY-SSK------------G---------------------
R
------------------
H
K
----
A
L
S
---
T
C
S
S
--
H
L
T
V
V
V
L
-----------
F
F
V
P
C
I
F
L
Y
M
R
P
V
V---T-------H-----P-I
D
----
K
---------
A
M
A---V-----------------S
D
S
-
I
I
T
P
M
L
---
N
-
P
L
I
Y
T
L-R
N
A
E
V
---
K
S
A
M
K
K
L
W
M
K
W
E
A
LAGK------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
90.05
16%
-155
- C5 -
2Z73
5
OPSD_TODPA
A:
[34-333]
-------------------------------------------------------------------
Y
Y
S
L
G
I
F
I
G
I
C
----
G
I
I
--
G
C
G
G
N
G
I
V
I
Y
L
--
F
T
K
T
K
S
-
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
-
L
V
N
G
F
P
-
L
M
--
T
I
S
C
F
-
L
K
K
W
I
F
G
F
-
A
A
C
K
V
Y
G
F
I
--
G
G
I
F
G
F
-
M
S
I
M
T
M
A
M
-
I
S
--
I
D
R
Y
N
V
I
--
G
R
P
M
A
A
S
K
K
---
M
S
H
R
R
A
----
F
I
M
I
------
I
F
V
---------
W
---
L
-
W
--
S
V
L
W
A
I
G
P
I
F
-
G
W
------------------------
G
A
Y
-------
T
-------------
L
E
G
V
L
C
N
--
C
S
F
D
Y
I
S
R
D
-------
S
-
T
T
R
S
N
------
I
L
C
-
M
F
I
L
G
F
-
F
G
P
I
L
-
I
-
I
--
F
F
C
Y
F
-------
N
I
--
V
M
S
--
V
S
N
H
-
E
K
E
------------
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
E
------------------
M
R
----
L
A
K
---
I
S
I
V
--
I
V
S
Q
F
L
L
-----------
S
W
S
P
Y
A
V
V
A
L
L
A
Q
F
---
G
-------
P
LEWVT
P
-
Y
A
----
A
---------
Q
L
P
---
V
-----------------
M
F
A
-
K
A
S
A
I
H
---
N
-
P
M
I
Y
S
V
-
S
H
P
K
F
---
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
Q
F
------------------------------------------------------------------------------------------------------------------------------------------------
40
Fugue
88.10
17%
-142
- C5 -
1F88
8
OPSD_BOVIN
A:
[1-348]
---------------MN
G
T
E
G
PNFYVP
F
S
N
K
T
G
V
V
R
S
P
F
E
A
-
P
Q
Y
---------------
Y
L
AE
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
----
I
M
L
--
G
F
P
I
N
F
L
T
L
Y
V
--
T
V
Q
H
K
K
-
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
-
F
G
G
-
F
T
-
T
T
--
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
-
T
G
C
N
L
E
G
F
F
--
A
T
L
G
G
E
-
I
A
L
W
S
L
V
V
-
L
A
--
I
E
R
Y
V
V
V
--
C
K
P
M
S
-
N
F
R
---
F
G
E
N
H
A
----
I
M
G
V
------
A
F
T
---------
W
---
V
-
M
--
A
L
A
C
A
A
P
P
L
V
G
W
S
------------------------
R
Y
I
-------
P
E
GMQC
S
---
C
-
G
I
----------
D
Y
Y
T
P
H
E
E
T
N
N
-
E
S
-
F
-
V
I
Y
M
F
------
V
V
------
H
F
-
I
I
P
L
I
-
V
-
I
--
F
F
C
Y
G
-------
Q
L
--
V
F
T
--
V
K
E
A
A
A
S
A
------------
T
---------------------
T
------------------
Q
K
----
A
E
K
---
E
V
T
R
--
M
V
I
I
M
V
I
-----------
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
---
Y
-------
I
-----
F
-
T
H
----
Q
GSDFGPIFM
T
I
P
---
A
-----------------
F
F
A
-
K
T
S
A
V
Y
---
N
-
P
V
I
Y
I
M
-
M
N
K
Q
F
---
R
N
C
M
V
T
T
L
C
C
G
K
N
P
S
T
T
VSKTETS
Q
V
A
P
A------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
87.12
16%
-159
- C5 -
2KS9
1
NK1R_HUMAN
A:
[34-325]
---------------------------------------------------------------------
L
W
A
A
A
Y
T
V
I
----
V
V
T
--
S
V
V
G
N
V
V
V
M
W
I
--
I
L
A
H
K
R
-
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
-
A
F
N
-
T
V
-
V
N
--
F
T
Y
A
V
-
H
N
E
W
Y
Y
G
L
-
F
Y
C
K
F
H
N
F
F
--
P
I
A
A
V
F
-
A
S
I
Y
S
M
T
A
-
V
A
--
F
D
R
Y
M
A
I
--
I
H
P
L
Q
P
R
L
-----
S
A
T
A
T
----
K
V
V
I
------
C
V
I
---------
W
---
V
-
L
--
A
L
L
L
A
F
P
Q
G
Y
-
Y
S
------------------------
T
-
T
-------
E
-------------
T
M
P
S
R
V
V
--
C
M
I
E
W
P
E
H
P
N
K
---
I
-
Y
--
E
K
V
Y
------
H
I
C
-
V
T
V
L
I
Y
-
F
L
P
L
L
-
V
-
I
--
G
Y
A
Y
T
-------
V
V
--
G
I
T
--
L
W
A
S
-
E
I
P
GDSSDRYH
E
Q
V
S
A
---------------------
K
------------------
R
K
----
V
V
K
---
M
M
I
V
--
V
V
C
T
F
A
I
-----------
C
W
L
P
F
H
I
F
F
L
L
P
Y
I
---
N
PDL----
Y
L----
K
K
F
I
Q
Q
V
-
Y
---------
L
A
I
---
M
-----------------
W
L
A
-
M
S
S
T
M
Y
---
N
-
P
I
I
Y
C
C
-
L
N
D
R
F
---
R
L
G
F
K
H
A
F
R
C
C
P
F
I
S
A
G
------------------------------------------------------------------------------------------------------------------------------------------------
39
Fugue
84.99
17%
-122
- C5 -
1U19
15
OPSD_BOVIN
A:
[4-349]
---------------------------
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
-
N
K
T
GVVRSPFEAPQYYLA
E
P
---
W
Q
F
S
M
L
A
A
Y
M
F
L
L
----
I
M
L
--
G
F
P
I
N
F
L
T
L
Y
V
--
T
V
Q
H
K
K
-
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
-
F
G
G
-
F
T
-
T
T
--
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
-
T
G
C
N
L
E
G
F
F
--
A
T
L
G
G
E
-
I
A
L
W
S
L
V
V
-
L
A
--
I
E
R
Y
V
V
V
--
C
K
P
M
S
-
N
F
R
---
F
G
E
N
H
A
----
I
M
G
V
------
A
F
T
---------
W
---
V
-
M
--
A
L
A
C
A
A
P
P
L
V
G
W
S
------------------------
R
Y
I
-------
P
E
GMQC
S
---
C
-
G
I
----------
D
Y
Y
T
P
H
E
E
T
N
N
-
E
S
-
F
-
V
I
Y
M
F
------
V
V
H
-
F
I
I
P
L
I
-
V
I
F
F
C
-
Y
-
G
--
Q
L
V
F
T
-------
V
K
--
E
A
A
--
A
Q
Q
Q
-
E
S
A
------------
T
---------------------
T
------------------
Q
K
----
A
E
K
---
E
V
T
R
--
M
V
I
I
M
V
I
-----------
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
---
Y
I
F
T
H
QG-
S
-----
D
-
F
G
----
P
---------
I
F
M
---
T
-----------------
I
P
A
-
F
F
A
K
T
S
AV
Y
N
-
P
V
I
Y
I
M
-
M
N
K
Q
F
---
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
DEA
S
T
T
V
S
K
TETSQVAPA------------------------------------------------------------------------------------------------------------------------------
44
Fugue
78.75
15%
-157
- C2 -
4DVG
-
?
B:
[8-312]
----------------------------
E
V
V
Q
Q
K
F
A
I
V
A
K
E
M
K
I
D
---------------
N
P
---
E
L
I
T
I
P
N
Q
W
K
L
V
Q
E
---
Y
E
K
--
K
Q
K
K
D
I
R
I
Q
L
N
--
A
Q
K
T
G
N
-
W
R
N
A
I
T
D
P
K
Y
L
A
D
L
L
K
T
R
D
D
M
D
L
L
-
N
E
M
V
V
--
V
F
R
S
S
-
S
-------------
V
S
F
I
--
K
T
F
V
S
V
-
G
G
--
L
A
N
L
M
A
I
--
Y
K
K
K
I
E
----
A
E
N
S
N
T
A
I
---
D
E
E
R
K
C
----
C
E
V
L
------
R
Y
V
---------
F
---
A
E
E
--
D
A
T
V
A
L
I
E
I
D
-
G
G
------------------------
V
E
L
-------
L
-----
L
K
G
M
N
-
S
K
R
I
T
P
D
N
Q
--
L
D
I
L
L
E
I
T
L
T
S
S
M
V
E
-
H
-
P
S
Q
E
G
------
L
Y
L
-
G
G
D
V
C
V
M
N
A
F
S
N
-
L
-
V
--
S
E
G
V
D
M------
K
K
--
F
L
S
--
F
F
S
L
-
F
S
K
------------
S
---------------------
K
--------------------------------
S
E
--
K
F
K
H
A
S
L
-----------
V
L
I
N
N
L
I
D
--
Q
P
E
L
---
E
-------
H
-----
R
M
D
V
----
R
---------
N
S
F
---
I
-----------------
E
I
G
-
L
V
N
E
L
E
---
N
M
K
N
T
-
E
W
M
K
I
D
K
I
---
K
D
S
I
N
D
F
F
D
S
W
E
E
D
K
K
E
V
E
S
R
F
D
D
L----------------------------------------------------------------------------------------------------------------------------------------
41
Fugue
78.57
13%
-143
- C5 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
------------------------------------------------------------
D
E
---
V
W
V
V
G
M
G
I
V
M
S
L
I
----
V
L
A
--
I
V
F
G
N
V
L
V
I
T
A
--
I
A
K
F
E
R
-
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
-
L
A
V
-
V
P
-
F
G
--
A
A
H
I
L
-
M
K
M
W
T
F
G
N
-
F
W
C
E
F
W
T
S
I
--
D
V
L
C
V
T
-
A
S
I
E
T
L
C
V
-
I
A
--
V
D
R
Y
F
A
I
--
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
----
R
V
I
I
------
L
M
V
---------
W
---
I
-
V
--
S
G
L
T
S
F
L
P
I
Q
-
M
H
------------------------
W
Y
R
-------
A
TH
Q
--
E
---
A
-
I
N
C
Y
A
E
E
T
C
--
C
D
F
F
T
N
Q
A
Y
A
I
A
-
S
S
-
I
-
V
S
F
Y
V
------
P
L
V
-
I
M
V
F
V
Y
-
S
R
V
F
Q
-
E
-
A
--
K
R
Q
L
N
-------
I
F
--
E
M
L
--
R
I
D
E
-
G
L
R
------------
L
---------------------
K
------------------
I
Y
----
K
D
T
---
E
G
Y
Y
--
T
I
G
I
G
H
L
-----------
L
T
K
S
P
S
L
N
A
A
K
S
E
L
---
D
-------
K
-----
A
-
I
G
----
R
---------
N
T
N
GVI
T
-----------------
K
D
E
-
A
E
K
L
F
N
---
Q
-
D
V
D
A
A
V
-
R
G
I
L
R
---
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL
30
HHSearch
76.93
15%
-142
- C5 -
1U19
14
OPSD_BOVIN
A:
[41-328]
--------------------------------------------------------------------
S
M
L
A
A
Y
M
F
L
L
----
I
M
L
--
G
F
P
I
N
F
L
T
L
Y
V
--
T
V
Q
H
K
K
-
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
-
F
G
G
-
F
T
-
T
T
--
L
Y
T
S
L
-
H
G
Y
F
V
F
G
P
-
T
G
C
N
L
E
G
F
F
--
A
T
L
G
G
E
-
I
A
L
W
S
L
V
V
-
L
A
--
I
E
R
Y
V
V
V
--
C
K
P
M
S
N
F
R
F
----
G
E
N
H
A
----
I
M
G
V
------
A
F
T
---------
W
---
V
-
M
--
A
L
A
C
A
A
P
P
L
V
-
G
W
------------------------
S
R
Y
-------
I
------------
P
-
E
G
M
Q
C
S
--
C
G
I
D
Y
Y
T
P
H
E
---
E
T
-
N
-
N
-
E
S
F
------
V
I
Y
-
M
F
V
V
H
F
-
I
I
P
L
I
-
V
-
I
--
F
F
C
Y
G
-------
Q
L
--
V
F
T
--
V
K
E
A
-
A
A
Q
------------
Q
---------------------
Q
ESA
T
T
Q
K
A
E
---------
K
E
----
V
T
R
---
M
V
I
I
--
M
V
I
A
F
L
I
-----------
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
---
H
QGSD---
F
-----
G
P
I
F
----
M
---------
T
I
P
---
A
-----------------
F
F
A
-
K
T
S
A
V
Y
---
N
-
P
V
I
Y
I
M
-
M
N
K
Q
F
---
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
------------------------------------------------------------------------------------------------------------------------------------------------
48
Fugue
73.14
18%
-155
- C4 -
4BUC
16
MURD_THEMA
A:
[16-448]
----PRGSH
M
K
I
G
F
LGFG
K
S
N
R
S
L
L
K
Y
L
L
N
H
Q
E
A
K
F
F
V
S
E
A
-
K
T
L
---------------
D
G
---
E
T
K
K
F
L
E
E
H
S
V
E
Y
E
E
GG
H
T
E
--
K
L
L
D
C
D
V
V
Y
V
S
PG
I
K
P
D
T
S
M
I
E
L
L
S
S
R
G
V
K
L
S
T
E
L
Q
F
F
L
D
-
N
V
D
-
P
K
-
K
V
V
G
I
T
G
T
D
-
G
K
S
T
A
T
A
L
M
Y
H
V
L
S
G
R
G
F
--
K
T
F
L
G
G
N
F
G
T
P
A
V
E
A
-
L
E
GE
Y
D
Y
Y
V
L
E
M
S
S
F
Q
L
F
W
S
-----
E
R
P
Y
L
S
----
N
F
L
V
LNISED
H
L
D
---------
W
HSS
F
-
K
--
E
Y
V
D
S
K
L
K
P
A
-
F
L
QTEG
D
L
F
V
Y
NKHIERLRNLEGVRS
R
K
I
-------
P
-----
F
---
W
T
D
E
N
F
A
T
E
--------
K
E
L
I
V
R
G
K
-
K
Y
-
T
-
L
P
G
N
Y
------
P
Y
Q
M
R
E
N
I
L
A
-
V
S
V
L
Y
M
E
M
F
NE
L
E
S
F
L
-------
E
L
--
L
R
D
--
F
K
P
L
-
P
H
R
M-----------
E
---------------------
Y
LGQIDG
R
H
F
Y
N
DSKATS
T
H
A
----
V
L
G
---
A
L
S
N
--
F
D
K
V
V
L
I
M
C
G
IGKKENY
S
L
F
V
E
K
A
S
P
K
L
K
H
L
I
M
--
F
-------
G
-----
E
-
I
S
----
K
---------
E
L
A
---
P
FVGKIP
H
S
I
V
E
N
M
E
E
A
F
E
K
A
M
E
V
S
E
K
G
---
D
-
V
I
L
L
S
P
-
G
G
A
S
F
---
A
K
R
G
E
H
F
R
E
I
F
K
R
H
G
G
D
------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
71.17
16%
-141
- C5 -
2LNL
-
CXCR1_HUMAN
A:
[39-323]
-------------------------------------------------------------------
K
Y
V
V
I
I
A
Y
A
L
V
----
F
L
L
--
S
L
L
G
N
S
L
V
M
L
V
--
I
L
Y
S
R
V
-
G
R
S
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
F
A
-
L
-
T
-
L
P
-
I
W
--
A
A
S
K
--
V
N
G
W
I
F
G
T
-
F
L
C
K
V
V
S
L
L
--
K
E
V
N
F
Y
-
S
G
I
L
L
L
A
C
-
I
S
--
V
D
R
Y
L
A
I
--
V
H
A
T
R
T
L
T
----
Q
K
R
H
L
V
----
K
F
V
C
------
L
G
C
---------
W
---
G
-
L
--
S
M
N
L
S
L
P
F
F
L
-
F
R
------------------------
Q
A
Y
-------
H
------------
P
-
N
N
S
S
P
V
--
C
Y
E
V
L
G
N
D
T
----
A
K
-
W
--
R
M
V
L
------
R
I
L
-
P
H
T
F
G
F
-
I
V
P
L
F
-
V
-
M
--
L
F
C
Y
G
-------
F
T
--
L
R
T
--
L
F
K
A
-
H
M
G
------------
Q
---------------------
K
------------------
H
R
----
A
M
R
---
V
I
F
A
--
V
V
L
I
F
L
L
-----------
C
W
L
P
Y
N
L
V
L
L
A
D
T
L
M
RT
Q
VIQE
S
C
E
R
-----
R
-
N
N
I
G
R
A
L
---------
D
A
T
---
E
-----------------
I
L
G
-
F
L
H
S
C
L
---
N
-
P
I
I
Y
A
F
-
I
G
Q
N
F
---
R
H
G
F
L
K
I
L
A
M
H
G
-----------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
70.32
20%
-172
- C5 -
3EML
8
ENLYS_BPT4
A:
[22-222]
--------------------------------------------------------------------
S
V
Y
I
T
V
E
L
A
I
----
A
V
L
--
A
I
L
G
N
V
L
V
C
W
A
--
V
W
L
N
S
N
-
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
-
V
L
A
-
I
P
-
F
A
--
I
T
I
S
T
---
G
F
C
A
A
C
-
H
G
C
L
F
I
A
C
F
--
V
L
V
L
T
Q
-
S
S
I
F
S
L
L
A
-
I
A
--
I
D
R
Y
I
A
I
--
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
----
K
G
I
I
------
A
I
C
---------
W
---
V
-
L
--
S
F
A
I
G
L
T
P
M
L
-
G
W
------------------------
N
N
C
-------
G
-----
Q
-----------
S
Q
G
--
C
G
E
G
Q
---
V
A
C
L
-
F
E
D
V
V
P
M
N
Y
M
------
V
Y
F
-
N
F
F
A
C
V
-
L
V
P
L
L
-
L
-
M
--
L
G
V
Y
L
-------
R
I
--
F
L
A
--
A
R
R
Q
-
L
N
I
------------
F
---------------------
E
------------------
M
L
----
R
I
D
---
E
G
L
R
--
L
K
I
Y
K
D
T
-----------
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
---
S
-------
P
-----
S
-
L
N
----
A
---------
A
K
S
---
E
-----------------
L
D
K
-
A
I
G
R
N
T
---
N
-
G
V
I
T
K
D
-
E
A
E
K
L
---
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
70.14
18%
-165
* C5 *
2RH1
6
ADRB2_HUMAN (first)
A:
[41-236]
--------------------------------------------------------------------
V
G
M
G
I
V
M
S
L
I
----
V
L
A
--
I
V
F
G
N
V
L
V
I
T
A
--
I
A
K
F
E
R
-
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
-
L
A
V
-
V
P
-
F
G
--
A
A
H
I
L
-
M
K
M
W
T
F
G
N
-
F
W
C
E
F
W
T
S
I
--
D
V
L
C
V
T
-
A
S
I
E
T
L
C
V
-
I
A
--
V
D
R
Y
F
A
I
--
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
----
R
V
I
I
------
L
M
V
---------
W
---
I
-
V
--
S
G
L
T
S
F
L
P
I
Q
-
M
H
------------------------
W
Y
R
-------
A
-----
T
-----
H
---
Q
E
A
I
N
--
C
Y
A
E
----
E
T
C
C
-
D
F
-
F
-
T
N
Q
A
Y
------
A
I
A
-
S
S
I
V
S
F
-
Y
V
P
L
V
-
I
-
M
--
V
F
V
Y
S
-------
R
V
--
F
Q
E
--
A
K
R
Q
-
L
N
I
------------
F
---------------------
E
------------------
M
L
----
R
I
D
---
E
G
L
R
--
L
K
I
Y
K
D
T
-----------
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
---
S
-------
P
-----
S
-
L
N
----
A
---------
A
K
S
---
E
-----------------
L
D
K
-
A
I
G
R
N
T
---
N
-
G
V
I
T
K
D
-
E
A
E
K
L
---
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
68.23
19%
-176
- C5 -
3UON
2
ACM2_HUMAN (first)
A:
[25-215]
---------------------------------------------------------------------
F
I
V
L
V
A
G
S
L
----
S
L
V
--
T
I
I
G
N
I
L
V
M
V
S
--
I
K
V
N
R
H
-
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
-
V
F
S
-
M
N
-
L
Y
--
T
L
Y
T
V
-
I
G
Y
W
P
L
G
P
-
V
V
C
D
L
W
L
A
L
--
D
Y
V
V
S
N
-
A
S
V
M
N
L
L
I
-
I
S
--
F
D
R
Y
F
C
V
--
T
K
P
L
T
Y
P
V
K
---
R
T
T
K
M
A
----
G
M
M
I
------
A
A
A
---------
W
---
V
-
L
--
S
F
I
L
W
A
P
A
I
L
-
F
W
------------------------
Q
F
I
-------
V
-----
G
------
V
R
T
V
E
D
G
E
--
C
Y
I
Q
F
F
S
------------
N
A
A
V
------
T
F
G
-
T
A
I
A
A
F
-
Y
L
P
V
I
-
I
-
M
--
T
V
L
Y
W
-------
H
I
--
S
R
A
--
S
K
S
R
-
I
N
I
------------
F
---------------------
E
------------------
M
L
----
R
I
D
---
E
G
L
R
--
L
K
I
Y
K
D
T
-----------
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
---
S
-------
P
-----
S
-
L
N
----
A
---------
A
K
S
---
E
-----------------
L
D
K
-
A
I
G
R
N
T
---
N
-
G
V
I
T
K
D
-
E
A
E
K
L
---
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
66.25
18%
-158
- C5 -
3RZE
2
ENLYS_BPT4 (first)
A:
[11-201]
----------------------------------------------------------------------
L
V
V
V
L
S
T
I
----
C
L
V
--
T
V
G
L
N
L
L
V
L
Y
A
--
V
R
S
E
R
K
-
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
-
A
V
V
-
M
P
-
M
N
--
I
L
Y
L
L
-
M
S
K
W
S
L
G
R
-
P
L
C
L
F
W
L
S
M
--
D
Y
V
A
S
T
-
A
S
I
F
S
V
F
I
-
L
C
--
I
D
R
Y
R
S
V
--
Q
Q
P
L
R
Y
L
K
Y
---
R
T
K
T
R
A
----
S
A
T
I
------
L
G
A
---------
W
---
F
-
L
--
S
F
L
W
V
I
P
I
L
G
-
W
-------------------------
N
H
------------------------
R
R
E
D
K
--
C
E
T
D
F
Y
D
V
------------
T
W
F
------
K
V
M
-
T
A
I
I
N
F
-
Y
L
P
T
L
-
L
-
M
--
L
W
F
Y
A
-------
K
I
--
Y
K
A
--
V
R
Q
H
-
C
N
I
------------
F
---------------------
E
------------------
M
L
----
R
I
D
---
E
G
L
R
--
L
K
I
Y
K
D
T
-----------
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
---
S
-------
P
-----
S
-
L
N
----
A
---------
A
K
S
---
E
-----------------
L
D
K
-
A
I
G
R
N
T
---
N
-
G
V
I
T
K
D
-
E
A
E
K
L
---
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
------------------------------------------------------------------------------------------------------------------------------------------------
47
Fugue
64.99
15%
-151
- C3 -
3NVT
2
?
A:
[32-381]
----------------------------
E
L
R
T
Q
V
D
Q
L
N
I
D
L
-
L
E
L
---------------
I
S
---
K
R
A
N
L
V
Q
E
I
G
K
I
K
----
G
R
F
--
D
P
L
R
E
R
E
M
L
N
T
--
I
L
A
A
N
E
-
G
P
F
E
---
D
S
T
V
Q
K
L
F
K
E
I
F
K
-
A
G
L
-
E
L
-
Q
E
--
E
D
H
S
K
-
A
L
L
V
S
R
K
N
-
K
K
E
D
T
I
V
T
V
KG
L
P
I
G
N
G
-
E
P
V
F
V
F
G
P
-
C
S
--
V
E
S
Y
E
Q
V
--
A
A
V
A
E
S
I
K
A
---
K
G
L
K
-------
L
I
R
------
G
G
A
F
K
P
R
TSPYD
F
---
Q
-
G
--
L
G
L
E
G
L
K
I
L
K
-
R
V
------------------------
S
D
E
Y
G
L
G
V
I
S
E
-----
I
---
V
-
T
P
A
D
I
E
V
A
L
DY
V
D
V
I
Q
I
G
A
R
N
M
Q
-
N
F
-
E
-
L
L
K
A
A
G
R
V
D
K
P
I
L
L
-
K
R
G
L
S
A
-
T
I
E
E
F
-
I
-
G
--
A
A
E
Y
I
M
S
Q
GNGK
I
I
--
L
C
E
R
G
I
R
T
Y
-
E
K
A
------------
T
---------------------
R
------------------
N
T
LD
I
S
A
V
P
---
I
L
K
K
E
T
H
L
P
V
M
V
D
--------------
V
T
H
S
T
G
R
K
D
L
L
---
L
-------
P
-----
C
-
A
K
----
A
---------
A
L
A
---
I
E----------------
A
D
G
-
V
M
A
E
V
H
---
P
-
D
P
A
V
A
L
-
S
D
S
A
Q
QMD
I
P
E
F
E
E
F
W
N
A
I
L
A
S
N
L
V
P-----------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
64.77
21%
-173
- C5 -
3PBL
1
DRD3_HUMAN (first)
A:
[41-227]
----------------------------------------------------------------------
Y
A
L
S
Y
C
A
L
----
I
L
A
--
I
V
F
G
N
G
L
V
C
M
A
--
V
L
K
E
R
A
-
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
-
T
L
V
-
M
P
-
W
V
--
V
Y
L
E
V
T
G
G
V
W
N
F
S
R
-
I
C
C
D
V
F
V
T
L
--
D
V
M
M
C
T
-
A
S
I
W
N
L
C
A
-
I
S
--
I
D
R
Y
T
A
V
--
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
----
A
L
M
I
------
T
A
V
---------
W
---
V
-
L
--
A
F
A
V
S
C
P
L
L
F
-
G
F
------------------------
N
T
T
-----------------------
G
D
P
T
V
--
C
S
I
S
N
P
--------
D
-------
F
------
V
I
Y
-
S
S
V
V
S
F
-
Y
L
P
F
G
-
V
-
T
--
V
L
V
Y
A
-------
R
I
--
Y
V
V
--
L
K
Q
R
-
R
R
K
------------
N
---------------------
I
------------------
F
E
----
M
L
R
---
I
D
E
G
--
L
R
L
K
I
Y
K
-----------
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
---
T
-------
K
-----
S
-
P
S
----
L
---------
N
A
A
---
K
-----------------
S
E
L
-
D
K
A
I
G
R
---
N
-
T
N
G
V
I
T
-
K
D
E
A
E
---
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
------------------------------------------------------------------------------------------------------------------------------------------------
46
Fugue
63.88
11%
-156
- C1 -
3EH0
-
LPXD_ECOLI
A:
[1-341]
MASIR
L
A
D
L
A
Q
Q
L
D
A
E
L
H
G
DGDIVIT
G
V
A
S
M
Q
S
A
Q
T
G
H
I
T
F
-
M
V
N
---------------
P
K
---
Y
R
E
H
L
G
L
C
Q
A
S
A
V
----
V
M
T
--
Q
D
D
L
P
F
A
-
K
S
A
--
A
L
V
V
K
N
-
P
Y
L
T
Y
A
R
M
A
Q
I
L
D
T
T
P
Q
P
A
Q
-
N
I
A
-
P
S
-
A
V
--
I
D
A
T
A
-
K
L
G
N
N
V
S
I
-
G
A
N
A
V
I
E
S
G
--
V
E
L
G
D
N
-
V
I
I
G
A
G
C
F
-
V
G
--
K
N
S
K
I
G
A
--
G
S
R
L
W
A
N
V
T
---
I
Y
H
E
I
Q
I
G
Q
N
C
L
I
Q
------
S
G
T
---------
V
---
V
-
G
AD
G
F
G
Y
A
N
D
R
G
N
-
W
V
------------------------
K
I
P
-------
Q
-----
I
---
G
-
R
V
I
I
G
D
R
V
E
--
I
G
A
C
T
T
I
D
R
G
A
L
-
D
D
-
T
-
I
I
G
N
G
------
V
I
I
-
D
N
Q
C
Q
I
-
A
--
H
N
-
V
-
V
--
I
G
D
N
T
-------
A
V
A
G
G
V
I
--
M
A
G
S
-
L
K
I
------------
G
---------------------
R
------------------
Y
C
----
M
I
G
G
A
S
V
I
N
G
--
H
M
E
I
C
----------------
D
K
V
T
V
T
G
M
G
M
V
---
M
-------
R
-----
P
-
I
T
----
E
---------
P
G
V
---
Y
-----------------
S
S
G
-
I
P
L
Q
P
N
---
K
-
V
W
R
K
T
A
-
A
L
V
M
N
---
I
D
D
M
S
K
R
L
K
S
L
E
R
K
V
N
Q
Q
D----------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
62.66
22%
-165
- C5 -
4U15
1
ACM3_RAT
A:
[9-150]
------------------------------------------------------------------
I
W
Q
V
V
F
I
A
F
L
T
G
----
F
L
A
L
V
T
I
I
G
N
I
L
V
I
V
A
--
F
K
V
N
K
Q
-
L
K
T
V
N
N
Y
F
L
L
S
L
A
C
A
D
L
I
I
G
-
V
I
S
-
M
N
-
L
F
--
T
T
Y
I
I
-
M
N
R
W
A
L
G
N
-
L
A
C
D
L
W
L
S
I
--
D
Y
V
A
S
N
-
A
S
V
M
N
L
L
V
-
I
S
--
F
D
R
Y
F
S
I
--
T
R
P
L
T
Y
R
A
K
---
R
T
T
K
R
A
----
G
V
M
I
------
G
L
A
---------
W
---
V
-
I
--
S
F
V
L
W
A
P
A
I
L
-
F
W
------------------------
Q
Y
F
-------
V
-----
G
---
K
-
R
T
V
P
P
G
E
C
F
--
I
Q
F
L
S
E
P
T
I
T
F
G
-
T
A
-
I
-
A
A
F
Y
M
------
P
V
T
-
I
M
T
I
L
Y
-
W
R
I
Y
K
-
E
-
T
--
E
K
M
N
I
-------
F
E
--
M
L
R
--
I
D
E
G
-
G
G
S
------------
G
---------------------
G
------------------
D
E
----
A
E
K
---
L
F
N
Q
--
D
V
D
A
A
V
R
-----------
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
---
L
-------
D
-----
A
-
V
R
----
R
---------
A
A
L
---
I
-----------------
N
M
V
-
F
Q
M
G
E
T
---
G
-
V
A
G
F
T
N
-
S
L
R
M
L
---
Q
Q
K
R
W
D
E
A
A
V
N
L
A
K
S
R
W
------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
61.76
22%
-164
- C5 -
4U16
1
?
A:
[9-150]
------------------------------------------------------------------
I
W
Q
V
V
F
I
A
F
L
T
G
----
F
L
A
L
V
T
I
I
G
N
I
L
V
I
V
A
--
F
K
V
N
K
Q
-
L
K
T
V
N
N
Y
F
L
L
S
L
A
C
A
D
L
I
I
G
-
V
I
S
-
M
N
-
L
F
--
T
T
Y
I
I
-
M
N
R
W
A
L
G
N
-
L
A
C
D
L
W
L
S
I
--
D
Y
V
A
S
N
-
A
S
V
M
N
L
L
V
-
I
S
--
F
D
R
Y
F
S
I
--
T
R
P
L
T
Y
R
A
K
---
R
T
T
K
R
A
----
G
V
M
I
------
G
L
A
---------
W
---
V
-
I
--
S
F
V
L
W
A
P
A
I
L
-
F
W
------------------------
Q
Y
F
-------
V
-----
G
---
K
-
R
T
V
P
P
G
E
C
F
--
I
Q
F
L
S
E
P
T
I
T
F
G
-
T
A
-
I
-
A
A
F
Y
M
------
P
V
T
-
I
M
T
I
L
Y
-
W
R
I
Y
K
-
E
-
T
--
E
K
M
N
I
-------
F
E
--
M
L
R
--
I
D
E
G
-
G
G
S
------------
G
---------------------
G
------------------
D
E
----
A
E
K
---
L
F
N
Q
--
D
V
D
A
A
V
R
-----------
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
---
L
-------
D
-----
A
-
V
R
----
R
---------
A
A
L
---
I
-----------------
N
M
V
-
F
Q
M
G
E
T
---
G
-
V
A
G
F
T
N
-
S
L
R
M
L
---
Q
Q
K
R
W
D
E
A
A
V
N
L
A
K
S
R
W
------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
61.73
22%
-174
- C5 -
4U14
1
ENLYS_BPT4
A:
[9-150]
------------------------------------------------------------------
I
W
Q
V
V
F
I
A
F
L
T
G
----
F
L
A
L
V
T
I
I
G
N
I
L
V
I
V
A
--
F
K
V
N
K
Q
-
L
K
T
V
N
N
Y
F
L
L
S
L
A
C
A
D
L
I
I
G
-
V
I
S
-
M
N
-
L
F
--
T
T
Y
I
I
-
M
N
R
W
A
L
G
N
-
L
A
C
D
L
W
L
S
I
--
D
Y
V
A
S
N
-
A
S
V
M
N
L
L
V
-
I
S
--
F
D
R
Y
F
S
I
--
T
R
P
L
T
Y
R
A
K
---
R
T
T
K
R
A
----
G
V
M
I
------
G
L
A
---------
W
---
V
-
I
--
S
F
V
L
W
A
P
A
I
L
-
F
W
------------------------
Q
Y
F
-------
V
-----
G
---
K
-
R
T
V
P
P
G
E
C
F
--
I
Q
F
L
S
E
P
T
I
T
F
G
-
T
A
-
I
-
A
A
F
Y
M
------
P
V
T
-
I
M
T
I
L
Y
-
W
R
I
Y
K
-
E
-
T
--
E
K
M
N
C
-------
F
E
--
M
L
R
--
I
D
E
G
-
L
R
L
------------
K
---------------------
I
------------------
Y
K
----
D
C
E
---
G
Y
Y
T
--
I
G
I
G
H
L
L
-----------
T
K
S
P
S
L
N
A
A
K
S
E
L
D
---
K
-------
A
-----
I
-
G
R
----
N
---------
T
N
G
---
V
-----------------
I
T
K
-
D
E
A
E
K
L
---
F
-
N
Q
D
V
D
A
-
A
V
R
G
I
---
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
61.67
22%
-174
- C5 -
4DAJ
2
ACM3_RAT (first)
A:
[9-150]
------------------------------------------------------------------
I
W
Q
V
V
F
I
A
F
L
T
G
----
F
L
A
L
V
T
I
I
G
N
I
L
V
I
V
A
--
F
K
V
N
K
Q
-
L
K
T
V
N
N
Y
F
L
L
S
L
A
C
A
D
L
I
I
G
-
V
I
S
-
M
N
-
L
F
--
T
T
Y
I
I
-
M
N
R
W
A
L
G
N
-
L
A
C
D
L
W
L
S
I
--
D
Y
V
A
S
N
-
A
S
V
M
N
L
L
V
-
I
S
--
F
D
R
Y
F
S
I
--
T
R
P
L
T
Y
R
A
K
---
R
T
T
K
R
A
----
G
V
M
I
------
G
L
A
---------
W
---
V
-
I
--
S
F
V
L
W
A
P
A
I
L
-
F
W
------------------------
Q
Y
F
-------
V
-----
G
---
K
-
R
T
V
P
P
G
E
C
F
--
I
Q
F
L
S
E
P
T
I
T
F
G
-
T
A
-
I
-
A
A
F
Y
M
------
P
V
T
-
I
M
T
I
L
Y
-
W
R
I
Y
K
-
E
-
T
--
E
K
M
N
I
-------
F
E
--
M
L
R
--
I
D
E
G
-
L
R
L
------------
K
---------------------
I
------------------
Y
K
----
D
T
E
---
G
Y
Y
T
--
I
G
I
G
H
L
L
-----------
T
K
S
P
S
L
N
A
A
K
S
E
L
D
---
K
-------
A
-----
I
-
G
R
----
N
---------
T
N
G
---
V
-----------------
I
T
K
-
D
E
A
E
K
L
---
F
-
N
Q
D
V
D
A
-
A
V
R
G
I
---
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
------------------------------------------------------------------------------------------------------------------------------------------------