@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR4CF_HUMAN: (2016-01-13 )
MQNQSFVTEFVLLGLSQNPNVQEIVFVVFLFVYIATVGGNMLIVVTILSSPALLVSPMYFFLGFLSFLDACFSSVITPKMIVDSLYVTKTISFEGCMMQLFAEHFFAGVEVIVLTAMAYDRYVAICKPLHYSSIMNRRLCGILMGVAWTGGLLHSMIQILFTFQLPFCGPNVINHFMCDLYPLLELACTDTHIFGLMVVINSGFICIINFSLLLVSYAVILLSLRTHSSEGRWKALSTCGSHIAVVILFFVPCIFVYTRPPSAFSLDKMAAIFYIILNPLLNPLIYTFRNKEVKQAMRRIWNRLMVVSDEKENIKL
Atome Classification :
(20 SA)
.........10...----------------.....20..---------------......30--.......--.40........50..-......60........70.....-..-.80........90..--..---....100.......110....-------...120.......130.......140.......150.....------------..160...--..------------...170----------....------...180........190.........200.......-210.......220.....-..230----------.---------------------...-----------.....240.......250.--------......260-.--------.----.--.---...---------.270........280----.........290.......300----------........310....-----------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MQ
N
Q
S
F
V
T
E
F
V
L
LG----------------LSQNP
N
V
Q
E
---------------
I
V
F
V
V
F
L
F
--
V
Y
I
A
TVG--G
N
M
L
I
V
V
T
ILSS
P
A
L
-
L
V
S
P
M
Y
F
F
L
G
F
L
S
F
L
D
A
C
F
S
SVI-
T
P
-
K
M
I
V
D
S
L
Y
V
T
K
TISF--
E
G
---
C
M
M
Q
L
F
A
E
H
F
FA
G
V
E
V
I
V
L
T
A-------MAYD
R
Y
V
A
I
CKP
L
H
Y
S
S
I
M
N
R
R
L
C
G
I
L
M
G
V
AWT
G
G
L
L
H
S
M
I
------------
Q
I
L
-
F
TFQ--LP------------FC
G
P
N
V
----------
I
N
H
F
------
M
C
D
L
Y
-
P
L
L
E
L
ACTD--T
H
I
F
G
L
M
V
V
INS
G
F
I
C
I
I
N
-
F
S
L
L
L
V
S
Y
A
V
I
L
L
S
LRTH-SSE------------G---------------------R
W
K
-----------
A
L
S
T
C
G
S
H
I
A
V
V
I
L
F
F
V
P
C
--------
I
F
V
YTRPP--S--------A----F--
S
---
L
D
K
---------
M
A
-
A
I
F
Y
I
I
L
N
P
L
------
L
N
P
L
I
Y
T
FR
N
K
E
V
K
Q
A
M
R
R
I
W
-----------
N
R
L
M
V
VSDEKENIKL-----------------------------------------------------------------------------------------------------------------------------------------------------------
47
Fugue
82.78
16%
-129
- C1 -
1F88
8
OPSD_BOVIN
A:
[1-348]
-
M
N
G
T
E
G
P
N
F
Y
V
P
F
----------------
S
N
K
T
G
V
V
R
S
PFEAPQYYLAE
P
W
Q
F
S
M
L
A
A
Y
M
F
--
L
L
I
M
L
G
F
--
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
-
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
-
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
--
T
G
---
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
-------
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
-
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
------------
P
L
V
G
W
S
R
Y
--
I
P
E
GMQC-------
S
C
G
I
------------------------
D
Y
Y
-
T
P
H
E
E
T
N
N
E
--
S
F
V
I
Y
M
F
V
V
H
-----
F
I
I
P
-
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
S
A
------------
T
---------------------
T
Q
K
-----------
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
--------
W
L
P
Y
A
G
V
A
--
F
--------
Y
----
I
--
F
---
T
H
Q
GSDFGPIFM
T
I
-
P
A
F
F
A
K
T
S
A
V
------
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
-----------
C
C
G
K
N
P
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A-----------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
81.99
16%
-149
- C1 -
2KS9
1
NK1R_HUMAN
A:
[35-327]
-------------------------------------------------------
W
A
A
A
Y
T
V
--
I
V
V
T
S
V
V
--
G
N
V
V
V
M
W
I
I
L
A
H
K
R
M
--
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
S
M
A
A
F
N
-
T
V
-
V
N
F
T
Y
A
V
H
N
E
W
Y
Y
G
L
--
F
Y
---
C
K
F
H
N
F
F
P
I
A
A
V
F
A
S
I
Y
S
M
T
A
-------
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
--
S
A
T
A
T
K
V
V
I
C
V
I
W
V
L
A
L
L
L
A
F
P
------------
Q
G
Y
-
Y
S
T
T
---
E
----------------
T
M
----------
P
S
R
V
------
V
C
M
I
E
-
W
P
E
H
---
P
N
--
K
I
Y
E
K
V
Y
H
I
C
V
T
V
L
I
Y
F
L
P
-
L
L
V
I
G
Y
A
Y
T
V
V
G
I
T
L
W
A
S
-
E
I
P
GDSSDRYH
E
Q
V
S
A
---------------------
K
R
K
-----------
V
V
K
M
M
I
V
V
V
C
T
F
A
I
C
W
L
P
F
--------
H
I
F
F
L
L
P
Y
--
I
NPD-----
L
Y---
L
K-
K
FI
Q
Q
V
Y
---------
L
A
-
I
M
W
L
A
M
S
S
T
M
------
Y
N
P
I
I
Y
C
C
L
N
D
R
F
R
L
G
F
K
H
A
F
-----------
R
C
C
P
F
I
S
A
G
D
Y
E
G
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
81.38
21%
-139
- C1 -
4GRV
3
ENLYS_BPT4 (first)
A:
[23-322]
------------------------------
L
D
V
N
T
D
I
Y
S
---------------
K
V
L
V
T
A
I
Y
--
L
A
L
F
V
V
G
T
V
G
N
S
V
T
L
F
T
L
A
R
K
---S
L
Q
S
T
V
H
Y
H
L
G
S
L
A
L
S
D
L
L
I
L
L
L
A
-
M
P
-
V
E
L
Y
N
F
I
W
V
H
H
P
W
A
F
G
D
A
G
---
C
R
G
Y
Y
F
L
R
D
A
C
T
Y
A
T
A
L
N
V
A
S
-------
L
S
V
A
R
Y
L
A
I
C
H
P
F
K
A
K
T
L
M
S
R
S
R
T
K
K
F
I
S
A
I
W
L
A
S
A
L
L
A
-
I
------------
P
M
L
-
F
T
M
G
--
L
Q
N
RSADGTHPGG
L
V
C
T
P
I
V
D
T
A
T
V
K
V
V
I
Q
V
N
T
F
------
M
S
F
L
F
-
P
M
L
V
I
S
I
L
N
--
T
-------
V
I
A
N
K
L
T
V
M
V
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
---
D
T
E
------------
G
---------------------
Y
Y
T
IGIGHLLTKSP
S
L
N
A
A
K
S
E
L
D
K
---
R
N
T
N
G
--------
V
I
T
K
D
E
A
E
--
K
--------
L
----
F
--
N
---
Q
D
V
---------
D
A
-
A
V
R
G
I
L
R
N
A
K
------
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
-----------
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------
48
Fugue
80.44
19%
-109
- C1 -
1U19
15
OPSD_BOVIN
A:
[4-349]
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
NKTGVVRSPFEAPQYY
L
A
E
P
W
Q
F
S
M
---------------
L
A
A
Y
M
F
L
L
--
I
M
L
G
F
P
I
--
N
F
L
T
L
Y
V
T
V
Q
H
K
K
---
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
-
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
--
T
G
---
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
-------
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
-
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
-------------
P
P
L
-
V
G
W
S
R
Y
I
P
E
GMQC-------
S
C
G
I
------------------------
D
Y
Y
-
T
P
H
E
E
T
N
N
E
--
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
-
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
Q
Q
Q
-
E
S
A
------------
T
---------------------
T
Q
K
-----------
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
--
S
--------
D
----
F
--
G
---
P
I
F
---------
M
T
I
P
A
F
F
A
K
T
S
A
V
------
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
CGKNPLGDDE
A
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A----------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
80.37
22%
-146
- C1 -
2Y01
12
ADRB1_MELGA
A:
[26-298]
---------------------------------------------------------------------
V
A
--
G
N
V
L
V
I
A
A
I
-
G
S
T
Q
R
-
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
----
F
G
A
T
L
V
V
R
G
T
W
L
--
W
G
---
S
----
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
HWWRDED
P
Q
A
L
-
K
C
Y
Q
--
D
P
------------
G
C
C
D
F
V
----------
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
--------
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
-------------
S
R
V
M
L
M
R
E
H
----------------------------------------
K
-----------
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
----------
F
F
L
V
N
I
V
--
N
--------
V
----
F
--
N
---
R
D
L
---------
V
P
-
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
-----------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
80.10
22%
-145
- C1 -
2Y00
13
ADRB1_MELGA
A:
[26-298]
---------------------------------------------------------------------
V
A
--
G
N
V
L
V
I
A
A
I
-
G
S
T
Q
R
-
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
----
F
G
A
T
L
V
V
R
G
T
W
L
--
W
G
---
S
----
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
HWWRDED
P
Q
A
L
-
K
C
Y
Q
--
D
P
------------
G
C
C
D
F
V
----------
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
--------
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
-------------
S
R
V
M
L
M
R
E
H
----------------------------------------
K
-----------
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
----------
F
F
L
V
N
I
V
--
N
--------
V
----
F
--
N
---
R
D
L
---------
V
P
-
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
-----------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
80.03
23%
-146
- C1 -
2YCZ
2
ADRB1_MELGA
A:
[26-296]
---------------------------------------------------------------------
V
A
--
G
N
V
L
V
I
A
A
I
-
G
S
T
Q
R
-
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
----
F
G
A
T
L
V
V
R
G
T
W
L
--
W
G
---
S
----
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
HWWRDED
P
Q
A
L
-
K
C
Y
Q
--
D
P
------------
G
C
C
D
F
V
----------
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
--------
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
K
-
I
D
R
A
S
K
R
K
R
V
M
L
--
M
R
E
H
----------------------------------------
K
-----------
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
----------
F
F
L
V
N
I
V
--
N
--------
V
----
F
--
N
---
R
D
L
---------
V
P
-
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
-----------
A
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
79.68
16%
-151
- C1 -
2Z73
5
OPSD_TODPA
A:
[34-333]
-------------------------------------
Y
Y
---------------
S
L
G
I
F
I
G
I
--
C
G
I
I
G
C
G
--
G
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
--
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
-
L
M
T
I
S
C
F
L
K
K
W
I
F
G
F
--
A
A
---
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
-------
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
W
S
V
L
W
A
I
G
------------
P
I
F
-
G
W
G
A
--
Y
---------------
T
-
L
E
----------
G
V
L
C
------
N
C
S
F
D
-
Y
I
S
-----
R
--
D
S
T
T
R
S
N
I
L
C
M
F
I
L
G
F
F
G
P
-
I
L
I
I
F
F
C
Y
F
N
I
V
M
S
V
S
N
H
-
E
K
E
------------
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
E
M
R
-----------
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
--------
A
V
V
A
L
L
A
Q
--
F
--------
G
PLE-
W
VT
P
---
Y
A
A
---------
Q
L
-
P
V
M
F
A
K
A
S
A
I
------
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
-----------
P
W
V
L
T
C
C
Q
F
D
D
K
E
T
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
79.47
23%
-145
- C1 -
2YCX
3
ADRB1_MELGA
A:
[26-294]
---------------------------------------------------------------------
V
A
--
G
N
V
L
V
I
A
A
I
-
G
S
T
Q
R
-
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
----
F
G
A
T
L
V
V
R
G
T
W
L
--
W
G
---
S
----
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
HWWRDED
P
Q
A
L
-
K
C
Y
Q
--
D
P
------------
G
C
C
D
F
V
----------
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
--------
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
K
-
I
D
R
A
S
K
R
K
R
V
M
L
--
M
R
E
H
----------------------------------------
K
-----------
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
----------
F
F
L
V
N
I
V
--
N
--------
V
----
F
--
N
---
R
D
L
---------
V
P
-
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
79.37
23%
-142
- C1 -
2YCY
6
ADRB1_MELGA
A:
[26-296]
---------------------------------------------------------------------
V
A
--
G
N
V
L
V
I
A
A
I
-
G
S
T
Q
R
-
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
----
F
G
A
T
L
V
V
R
G
T
W
L
--
W
G
---
S
----
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
HWWRDED
P
Q
A
L
-
K
C
Y
Q
--
D
P
------------
G
C
C
D
F
V
----------
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
--------
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
---
D
R
A
S
K
R
K
R
V
M
L
--
M
R
E
H
----------------------------------------
K
-----------
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
----------
F
F
L
V
N
I
V
--
N
--------
V
----
F
--
N
---
R
D
L
---------
V
P
-
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
-----------
A
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
79.12
22%
-145
- C1 -
2Y02
13
ADRB1_MELGA
A:
[26-298]
---------------------------------------------------------------------
V
A
--
G
N
V
L
V
I
A
A
I
-
G
S
T
Q
R
-
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
----
F
G
A
T
L
V
V
R
G
T
W
L
--
W
G
---
S
----
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
HWWRDED
P
Q
A
L
-
K
C
Y
Q
--
D
P
------------
G
C
C
D
F
V
----------
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
--------
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
-------------
S
R
V
M
L
M
R
E
H
----------------------------------------
K
-----------
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
----------
F
F
L
V
N
I
V
--
N
--------
V
----
F
--
N
---
R
D
L
---------
V
P
-
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
-----------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
79.07
23%
-145
- C1 -
2VT4
8
ADRB1_MELGA
A:
[26-296]
---------------------------------------------------------------------
V
A
--
G
N
V
L
V
I
A
A
I
-
G
S
T
Q
R
-
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
----
F
G
A
T
L
V
V
R
G
T
W
L
--
W
G
---
S
----
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
HWWRDED
P
Q
A
L
-
K
C
Y
Q
--
D
P
------------
G
C
C
D
F
V
----------
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
--------
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
------------------
E
H
----------------------------------------
K
-----------
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
----------
F
F
L
V
N
I
V
--
N
--------
V
----
F
--
N
---
R
D
L
---------
V
P
-
D
W
L
F
V
A
F
N
W
L
G
Y
A
NSA
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
-----------
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
78.39
23%
-148
- C1 -
2YCW
7
ADRB1_MELGA
A:
[26-296]
---------------------------------------------------------------------
V
A
--
G
N
V
L
V
I
A
A
I
-
G
S
T
Q
R
-
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
-
V
P
----
F
G
A
T
L
V
V
R
G
T
W
L
--
W
G
---
S
----
F
L
C
E
L
W
T
S
L
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
T
S
P
F
R
Y
Q
S
L
M
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
HWWRDED
P
Q
A
L
-
K
C
Y
Q
--
D
P
------------
G
C
C
D
F
V
----------
T
N
R
A
Y
A
I
A
S
S
I
I
S
F
Y
I
P
L
L
I
M
--------
I
F
V
A
L
R
V
Y
R
E
A
K
E
Q
I
R
K
-
I
D
R
A
S
K
R
K
R
V
M
L
--
M
R
E
H
----------------------------------------
K
-----------
A
L
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
----------
F
F
L
V
N
I
V
--
N
--------
V
----
F
--
N
---
R
D
L
---------
V
P
-
D
W
L
F
V
A
F
N
W
L
G
Y
A
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
-----------
A
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
Fugue
76.63
13%
-126
- C1 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
---------------------------------
D
E
V
W
V
V
---------------
G
M
G
I
V
M
S
L
--
I
V
L
A
I
V
F
--
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
--
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
-
F
G
A
A
H
I
L
M
K
M
W
T
F
G
N
--
F
W
---
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
-------
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
------------
P
I
Q
-
M
H
W
Y
--
R
A
-----------------------------
T
H
Q
------
E
A
I
N
C
-
Y
A
E
E
T
C
C
D
F
--
F
-
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
-
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
-
L
N
I
------------
F
---------------------
E
M
L
-----------
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
--------
I
G
I
G
H
L
L
T
--
K
--------
S
----
P
--
S
---
L
N
A
---------
A
K
-
S
E
L
D
K
A
I
G
R
N
------
T
N
G
---
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
-----------
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL
39
HHSearch
72.65
14%
-148
- C1 -
1U19
14
OPSD_BOVIN
A:
[42-328]
------------------------------------------------------
M
L
A
A
Y
M
F
L
--
L
I
M
L
G
F
P
--
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
--
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
-
F
T
-
T
T
L
Y
T
S
L
H
G
Y
F
V
F
G
P
--
T
G
---
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
-------
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
-
F
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
------------
P
L
V
-
G
W
S
R
--
Y
---------------
I
P
-
E
----------
G
M
Q
C
------
S
C
G
I
D
-
Y
Y
T
P
---
H
E
--
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
-
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
-
A
A
Q
------------
Q
QESA
T
T
Q
K
A
------------
E
K
E
-----------
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
--------
A
G
V
A
F
Y
I
F
T
H
Q
--------
G
SD--
F
--
G
P--
I
F
M
---------
T
I
-
P
A
F
F
A
K
T
S
A
V
------
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
-----------
C
C
G
K
N
P
L
G
D
D
E
A
S
T
T
-----------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
72.45
18%
-140
- C1 -
2LNL
-
CXCR1_HUMAN
A:
[39-323]
-------------------------------------
K
Y
---------------
V
V
I
I
A
Y
A
L
--
V
F
L
L
S
L
L
--
G
N
S
L
V
M
L
V
I
L
Y
S
R
V
G
--
R
S
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
F
A
L
-
T
-
L
P
-
I
W
A
A
S
K
-
V
N
G
W
I
F
G
T
--
F
L
---
C
K
V
V
S
L
L
K
E
V
N
F
Y
S
G
I
L
L
L
A
C
-------
I
S
V
D
R
Y
L
A
I
V
H
A
T
R
T
L
T
-
Q
K
R
H
L
V
K
F
V
C
L
G
C
W
G
L
S
M
N
L
S
L
P
------------
F
F
L
-
F
R
Q
A
--
Y
---------------
H
P
-
N
----------
N
S
S
P
------
V
C
Y
E
V
-
L
G
N
D
----
T
--
A
K
W
R
M
V
L
R
I
L
P
H
T
F
G
F
I
V
P
-
L
F
V
M
L
F
C
Y
G
F
T
L
R
T
L
F
K
A
-
H
M
G
------------
Q
---------------------
K
H
R
-----------
A
M
R
V
I
F
A
V
V
L
I
F
L
L
C
W
L
P
Y
--------
N
L
V
L
L
A
D
T
--
L
M
RTQVIQE
S
C
E
R
R
N
--
N
I
G
-
R
A
L
---------
D
A
-
T
E
I
L
G
F
L
H
S
C
------
L
N
P
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
L
-----------
A
M
H
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
65.67
20%
-157
- C1 -
3EML
8
ENLYS_BPT4
A:
[22-221]
--------------------------------------
S
---------------
V
Y
I
T
V
E
L
A
--
I
A
V
L
A
I
L
--
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
--
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
-
F
A
I
T
I
S
T
--
G
F
C
A
A
C
--
H
G
---
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
-------
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
------------
P
M
L
-
G
W
N
N
--
C
G
------------
Q
-----------------
S
Q
------
G
C
G
E
G
-
Q
---
V
A
C
L
F
ED
V
V
P
M
N
Y
M
V
Y
F
N
F
F
A
C
V
L
V
P
-
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
-
L
N
I
------------
F
---------------------
E
M
L
-----------
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
--------
I
G
I
G
H
L
L
T
--
K
--------
S
----
P
--
S
---
L
N
A
---------
A
K
-
S
E
L
D
K
A
I
G
R
N
------
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
-----------
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
63.82
17%
-152
- C1 -
2RH1
6
ADRB2_HUMAN (first)
A:
[40-235]
-------------------------------------
V
V
---------------
G
M
G
I
V
M
S
L
--
I
V
L
A
I
V
F
--
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
--
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V
-
V
P
-
F
G
A
A
H
I
L
M
K
M
W
T
F
G
N
--
F
W
---
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
-------
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
------------
P
I
Q
-
M
H
W
Y
--
R
A
------------
T
----
H
----------
Q
E
A
I
------
N
C
Y
A
E
-----
E
T
C
C
D
--
F
F
T
N
Q
A
Y
A
I
A
S
S
I
V
S
F
Y
V
P
-
L
V
I
M
V
F
V
Y
S
R
V
F
Q
E
A
K
R
Q
-
L
N
I
------------
F
---------------------
E
M
L
-----------
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
--------
I
G
I
G
H
L
L
T
--
K
--------
S
----
P
--
S
---
L
N
A
---------
A
K
-
S
E
L
D
K
A
I
G
R
N
------
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
-----------
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
63.23
18%
-162
- C1 -
3UON
2
ACM2_HUMAN (first)
A:
[25-215]
------------------------------------------------------
F
I
V
L
V
A
G
S
--
L
S
L
V
T
I
I
--
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
--
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
V
F
S
-
M
N
-
L
Y
T
L
Y
T
V
I
G
Y
W
P
L
G
P
--
V
V
---
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
-------
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
------------
A
I
L
-
F
W
Q
F
--
I
V
--------------
G
V
R
T
----------
V
E
D
G
------
E
C
Y
I
Q
-
F
F
-----------
S
N
A
A
V
T
F
G
T
A
I
A
A
F
Y
L
P
-
V
I
I
M
T
V
L
Y
W
H
I
S
R
A
S
K
S
R
-
I
N
I
------------
F
---------------------
E
M
L
-----------
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
--------
I
G
I
G
H
L
L
T
--
K
--------
S
----
P
--
S
---
L
N
A
---------
A
K
-
S
E
L
D
K
A
I
G
R
N
------
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
-----------
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
60.06
25%
-173
- C1 -
4MQT
2
ACM2_HUMAN
A:
[39-178]
--------------------------------------
E
---------------
V
V
F
I
V
L
V
A
G
S
L
S
L
V
T
I
I
--
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
-
Q
T
V
N
N
Y
F
L
F
S
L
-----
A
C
A
D
L
I
I
-
G
V
F
S
M
N
L
Y
T
L
Y
T
V
I
G
Y
W
P
--
L
G
P
V
V
C
D
L
W
L
A
L
D
Y
V
V
S
N
A
S
V
M
N
L
L
I
-------
I
S
F
D
R
Y
F
C
V
T
K
P
L
T
Y
P
V
K
R
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
------------
A
I
L
-
F
W
Q
F
--
I
V
------------
G
V
R
T
V
E
----------
D
G
E
C
------
Y
I
Q
F
F
-
S
N
A
A
V
T
F
G
T
--
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
Y
W
H
I
-
S
R
A
S
K
P
S
R
E
K
K
V
T
R
T
I
L
A
-
I
L
L
------------
A
---------------------
F
I
I
-----------
T
W
A
P
Y
N
V
M
V
L
I
N
T
F
C
A
P
C
I
--------
P
N
T
V
W
T
I
G
--
Y
--------
W
----
L
--
C
---
Y
I
N
---------
S
T
-
I
N
P
A
C
Y
A
L
C
N
------
A
T
F
K
K
T
F
K
H
L
L
M
C
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------