@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR4E2_HUMAN: (2016-01-13 )
MDSLNQTRVTEFVFLGLTDNRVLEMLFFMAFSAIYMLTLSGNILIIIATVFTPSLHTPMYFFLSNLSFIDICHSSVTVPKMLEGLLLERKTISFDNCITQLFFLHLFACAEIFLLIIVAYDRYVAICTPLHYPNVMNMRVCIQLVFALWLGGTVHSLGQTFLTIRLPYCGPNIIDSYFCDVPLVIKLACTDTYLTGILIVTNSGTISLSCFLAVVTSYMVILVSLRKHSAEGRQKALSTCSAHFMVVALFFGPCIFIYTRPDTSFSIDKVVSVFYTVVTPLLNPFIYTLRNEEVKSAMKQLRQRQVFFTKSYT
Atome Classification :
(20 SA)
--------------.......--..10........------20..-------------......30.------.......40---........50........60........70----......-..80.....-...-90........100...-----------------....110----.......120..-----.....130.......140...-----------------....150-----....-...160......-----.-----.170--..--.....180.......190.......200---------.........210.....-----..220-----........230----------.---------------------.---------...-....---240--------------------..--------.....---.------250.--------......260.----.----.--.----...-270.......---.-280....--...290.------------......300----------------.......310.-------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--------------MDSL
N
Q
T--R
V
T
E
F
V
F
LGLTD------
N
R
V
L
-------------
E
M
L
F
F
M
A
F
S
------
A
I
Y
M
L
T
LSG---
N
I
L
I
I
I
A
TVFTPSLH
T
P
M
Y
F
F
L
SNLS
F
I
DI----CHSSV
T
-
V
P
K
M
L
E
G
L
L
-
L
ER-KTI
S
F
D
N
C
I
T
Q
L
F
F
L
H
-----------------
L
F
A
C
A
E
I
----
F
L
L
I
I
V
AYD
R
Y
V
-----
A
I
CTPLHYPNV
M
N
M
R
V
C
I
Q
L
V
-----------------
F
A
L
WLG
G
-----
T
V
H
S
-LG
Q
T
F
-
L
T
I
RLP-----Y-----CG
P
N
--
I
I
--
D
S
Y
FCDV
P
L
V
I
K
L
ACTDT
Y
L
T
G
I
L
I
V
-----------TNS
G
T
I
S
L
S
C
F
L
A
V
V
T
S
-----
Y
M
V
I
------
L
V
S
L
R
K
HSA------------E---------------------
G
---------
R
Q
K
-
A
L
S
T
---
C
S
---------------------
A
H
--------
F
M
V
V
A
---
L
------FFG
P
--------
C
I
F
I
Y
TRPDT----S----F--
S
----
I
D
K
-
V
-
V
S
V
F
Y
T
V
V
---
T
-
P
L
L
N
P
F
I
--
Y
T
L
R
N
E
E
------------
V
K
S
A
M
K
Q
L
R
----------------
Q
R
Q
V
F
F
TKSYT-------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
87.50
19%
-144
* C1 *
2Z73
5
OPSD_TODPA
A:
[32-333]
-------------------------------------------
A
V
-------------
Y
Y
S
L
G
I
F
I
G
------
I
C
G
I
I
G
C
G
G
---
N
G
I
V
I
Y
L
F
T
K
T
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
----
T
F
S
L
V
N
G
F
P
L
M
T
I
S
C
F
-
L
K
K
-
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
-----------------
I
F
G
F
M
S
I
----
M
T
M
A
M
I
S
I
D
R
Y
N
-----
V
I
G
R
P
M
A
A
S
K
K
M
S
H
R
R
A
F
I
M
I
-----------------
I
F
V
W
L
W
S
-----
V
L
W
A
-
I
G
P
I
F
-
G
W
G
A
Y
T
-----
L
-----------
E
G
--
V
L
C
N
C
S
F
D
Y
I
S
R
-----
D
S
T
T
R
S
N
I
L
-----------
C
M
F
I
L
G
F
F
G
P
I
L
I
I
F
F
C
-----
Y
F
N
I
------
V
M
S
V
S
N
H
E
K
------------
E
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
N
A
---------
E
M
R
-
L
A
K
I
---
S
I
---------------------
V
I
--------
V
S
Q
F
L
---
L
------
S
W
S
P
--------
Y
A
V
V
A
L
L
A
Q
F
----
G
PLE-
W
VT
P
----
Y
A
A
-
Q
-
L
P
V
M
F
A
K
A
---
S
-
A
I
H
N
P
M
I
--
Y
S
V
S
H
P
K
------------
F
R
E
A
I
S
Q
T
F
----------------
P
W
V
L
T
C
C
Q
F
D
D
-------------------------------------------------------------------------------------------------------------------------------------------------------
46
Fugue
81.17
19%
-172
- C1 -
4XGC
1
ORC5_DROME
E:
[1-458]
--------------
M
E
A
I
C
S
S
--
L
E
P
L
F
---
P
C
R
E
------
A
A
I
E
-------------
T
L
G
E
L
I
G
D
S
SETYPS
A
I
Y
L
F
G
H
S
G
---
T
G
K
T
A
L
T
R
A
F
L
K
E
C
G
K
R
Q
N
V
R
T
A
H
L
N
A
I
E
C
----
Y
T
T
K
I
M
-
L
E
I
L
L
D
S
L
A
-
P
D
Q
G
D
A
L
K
V
D
N
M
L
D
F
V
E
Q
L
R
-----------------
R
Q
A
A
T
R
V
ED
Q
G
F
L
I
A
V
D
N
A
E
R
L
R
DMDA
N
V
L
P
V
L
L
R
L
Q
E
L
T
N
L
N
L
C
V
I
L
L
S
QLPFEKFYNK
T
G
L
S
E
I
V
C
L
H
L
A
Q
YN
K
A
E
T
Q
R
I
-
L
G
S
D
F
-
Q
Q
V
R
N
Q
-----
L
-----
L
E
Q
K
--
K
R
--
L
E
I
C
Q
E
A
---
V
T
E
D
F
Y
N
N
Y
L
N
L
F
L
S
V
F
YKACRD
V
P
E
L
Q
L
T
A
R
K
C
L
S
T
Y
L
E
P
V
L
D
GTSRL
W
R
H
I
------
A
G
P
L
R
S
A
L
T
------------
Q
---------------------
I
---------
Y
M
R
-
I
E
S
L
E
L
P
Y
Y
---------------------
A
K
--------
F
L
L
I
A
---
A
------
F
L
A
S
H
N
AAKQDK
R
L
F
S
T
T
L
G
P
K
----
S
----
F
--
S
----
I
D
R
-
L
-
L
A
I
F
Y
A
I
L
---
E
-
E
K
V
G
L
--------
T
C
N
------------
L
L
S
Q
I
S
T
L
V
----------------
H
L
N
L
L
S
F
V
S
G
E
QNIME
G
S
A
R
L
Q
C
T
I
G
L
E
F
V
L
Q
I
G
K
V
V
GFNVRQYLCD-------------------------------------------------------------------------------------------------------------------
30
HHSearch
80.41
16%
-143
- C1 -
2KS9
1
NK1R_HUMAN
A:
[34-325]
------------------------------------------------------------
L
W
A
A
A
Y
T
------
V
I
V
V
T
S
V
V
G
---
N
V
V
V
M
W
I
I
L
A
H
K
R
M
R
T
V
T
N
Y
F
L
V
N
L
A
F
A
E
A
----
S
M
A
A
F
N
-
T
V
V
N
F
T
Y
A
V
-
H
N
E
-
W
Y
Y
G
L
F
Y
C
K
F
H
N
F
F
P
I
-----------------
A
A
V
F
A
S
I
----
Y
S
M
T
A
V
A
F
D
R
Y
M
-----
A
I
I
H
P
L
Q
P
R
L
--
S
A
T
A
T
K
V
V
I
-----------------
C
V
I
W
V
L
A
-----
L
L
L
A
-
F
P
Q
G
Y
-
Y
S
T
T
E
T
-----------------
M
P
--
S
R
V
V
C
M
I
E
W
P
E
H
P
N
---
K
I
Y
E
K
V
Y
H
I
-----------
C
V
T
V
L
I
Y
F
L
P
L
L
V
I
G
Y
A
-----
Y
T
V
V
------
G
I
T
L
W
A
S
E
I
PGDSSDRYH
E
Q
V
S
---------------------
A
---------
K
R
K
-
V
V
K
M
---
M
I
---------------------
V
V
--------
V
C
T
F
A
---
I
------
C
W
L
P
--------
F
H
I
F
F
L
L
P
Y
I
----
N
PDLY
L
--
K
KFI
Q
Q
V
Y
-
L
-
A
I
M
W
L
A
M
S
---
S
-
T
M
Y
N
P
I
I
--
Y
C
C
L
N
D
R
------------
F
R
L
G
F
K
H
A
F
----------------
R
C
C
P
F
I
S
A
G
D
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
78.00
22%
-129
- C1 -
1F88
7
OPSD_BOVIN
A:
[49-317]
----------------------------------------------------------------------------
M
L
G
F
P
I
---
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
-
L
Y
T
S
L
H
G
Y
F
-
V
F
G
-
P
T
----
G
C
N
L
E
G
F
F
A
T
-----------------
L
G
G
E
I
A
L
----
W
S
L
V
V
L
A
I
E
R
Y
V
-----
V
V
C
K
P
M
S
-----
N
F
R
F
----------------------------
G
-----
E
N
H
A
I
M
G
V
A
F
-
T
W
V
M
A
L
-----
A
-----
C
A
A
P
--
P
L
--
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
H
E
E
T
-----------
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
-----
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
------------
A
-----------------------------------
S
A
T
T
---
Q
K
---------------------
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
---
F
L
I
C
W
L
P
Y
A
G
V
--------
A
F
Y
I
F
T
H
Q
G
S
----
D
----
F
--
G
P---
I
F
M
-
T
-
I
P
A
F
F
A
K
T
---
S
-
A
V
Y
N
P
V
I
--
Y
I
M
M
N
K
Q
------------
F
R
N
C
M
V
T
T
L
----------------
C
C
G
K
N
P
S
T
T
V
S
-------------------------------------------------------------------------------------------------------------------------------------------------------
39
Fugue
77.94
18%
-116
- C1 -
1F88
8
OPSD_BOVIN
A:
[1-348]
-----------------
M
N
G
T
--
E
G
P
N
F
Y
V
P
F
S
N
K
------
T
G
V
V
RSPFEAPQYYLAE
P
W
Q
F
S
M
L
A
A
------
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
----
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
-
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
-----------------
L
G
G
E
I
A
L
----
W
S
L
V
V
L
A
I
E
R
Y
V
-----
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
-----------------
F
T
W
V
M
A
L
-----
A
C
A
A
-
P
P
L
V
G
-
W
S
R
Y
I
P
-----
E
GMQC
S
C
G
I
D
--
Y
Y
TP
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
-----------
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
S
A
-----------------
T
T
Q
K
A
E
K
------------
E
---------------------
V
---------
T
R
M
-
V
I
I
M
---
V
I
---------------------
A
F
--------
L
I
C
W
L
---
P
------
Y
A
G
V
--------
A
F
Y
I
F
T
H
Q
G
S
----
D
----
F
--
G
----
P
I
F
-
M
T
I
P
A
F
F
A
K
T
---
S
-
A
V
Y
N
P
V
I
--
Y
I
M
M
N
K
Q
------------
F
R
N
C
M
V
T
T
L
----------------
C
C
G
K
N
P
S
T
T
V
S
KTETS
Q
V
A
P
A---------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
77.46
22%
-138
- C1 -
3DQB
4
GNAT1_BOVIN (first)
A:
[49-317]
----------------------------------------------------------------------------
M
L
G
F
P
I
---
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
-
L
Y
T
S
L
H
G
Y
F
-
V
F
G
-
P
T
----
G
C
N
L
E
G
F
F
A
T
-----------------
L
G
G
E
I
A
L
----
W
S
L
V
V
L
A
I
E
R
Y
V
-----
V
V
C
K
P
M
S
-----
N
F
R
F
----------------------------
G
-----
E
N
H
A
I
M
G
V
A
F
-
T
W
V
M
A
L
-----
A
-----
C
A
A
P
--
P
L
--
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
H
E
E
T
-----------
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
-----
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
------------
A
---------------------
Q
---------
Q
Q
E
-
S
A
T
T
---
Q
K
---------------------
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
---
F
L
I
C
W
L
P
Y
A
G
V
--------
A
F
Y
I
F
T
H
Q
G
S
----
D
----
F
--
G
P
---
I
F
M
-
T
-
I
P
A
F
F
A
K
T
---
S
-
A
V
Y
N
P
V
I
--
Y
I
M
M
N
K
Q
------------
F
R
N
C
M
V
T
T
L
----------------
C
C
G
K
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
76.82
22%
-126
- C1 -
3C9L
13
OPSD_BOVIN
A:
[49-317]
----------------------------------------------------------------------------
M
L
G
F
P
I
---
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
-
L
Y
T
S
L
H
G
Y
F
-
V
F
G
-
P
T
----
G
C
N
L
E
G
F
F
A
T
-----------------
L
G
G
E
I
A
L
----
W
S
L
V
V
L
A
I
E
R
Y
V
-----
V
V
C
K
P
M
S
-----
N
F
R
F
----------------------------
G
-----
E
N
H
A
I
M
G
V
A
F
-
T
W
V
M
A
L
-----
A
-----
C
A
A
P
--
P
L
--
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
H
E
E
T
-----------
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
-----
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
------------
A
---------------------
Q
---------
Q
Q
E
-
S
A
T
T
---
Q
K
---------------------
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
---
F
L
I
C
W
L
P
Y
A
G
V
--------
A
F
Y
I
F
T
H
Q
G
S
----
D
----
F
--
G
P---
I
F
M
-
T
-
I
P
A
F
F
A
K
T
---
S
-
A
V
Y
N
P
V
I
--
Y
I
M
M
N
K
Q
------------
F
R
N
C
M
V
T
T
L
----------------
C
C
G
K
N
D
D
E
----------------------------------------------------------------------------------------------------------------------------------------------------------
40
Fugue
76.81
17%
-125
- C1 -
1U19
15
OPSD_BOVIN
A:
[4-349]
MN
G
T
E
G
PNFYVPFS
N
K
T
G
V
V
R
--
S
P
F
E
A
P
Q
Y
Y
L
A
E
------
P
W
Q
F
-------------
S
M
L
A
A
Y
M
F
-------
L
L
I
M
L
G
F
P
I
---
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
----
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
-
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
-----------------
L
G
G
E
I
A
L
----
W
S
L
V
V
L
A
I
E
R
Y
V
-----
V
V
C
K
P
M
S
N
F
R
F
G
E
N
H
A
I
M
G
V
A
-----------------
F
T
W
V
M
A
L
-----
A
C
A
A
-
P
P
L
V
G
-
W
S
R
Y
I
P
E
GMQC
S
-----
C
G
I
D
YY
T
P
--
H
E
E
T
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
-----------
F
C
Y
G
Q
L
V
F
T
--
V
K
E
A
A
A
-----
Q
Q
Q
E
------
S
A
T
T
Q
K
A
E
K
------------
E
---------------------
V
---------
T
R
M
-
V
I
I
M
---
V
I
---------------------
A
F
--------
L
I
C
W
L
---
P
------
Y
A
G
V
--------
A
F
Y
I
F
T
H
Q
G
S
----
D
----
F
--
G
----
P
I
F
M
T
-
I
P
A
F
F
A
K
T
---
S
-
A
V
Y
N
P
V
I
--
Y
I
M
M
N
K
Q
------------
F
R
N
C
M
V
T
T
L
C
CGKNPLGDDEA
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
-------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
76.50
22%
-112
- C1 -
3OAX
15
OPSD_BOVIN
A:
[52-318]
----------------------------------------------------------------------------
M
L
G
F
P
I
---
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
-
L
Y
T
S
L
H
G
Y
F
-
V
F
G
-
P
T
----
G
C
N
L
E
G
F
F
A
T
-----------------
L
G
G
E
I
A
L
----
W
S
L
V
V
L
A
I
E
R
Y
V
-----
V
V
C
K
P
M
S
-----
N
F
R
F
----------------------------
G
-----
E
N
H
A
I
M
G
V
A
F
-
T
W
V
M
A
L
-----
A
-----
C
A
A
P
--
P
L
--
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
H
E
E
T
-----------
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
-----
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
------------
A
---------------------
Q
---------
Q
Q
E
-
S
A
T
T
---
Q
K
---------------------
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
---
F
L
I
C
W
L
P
Y
A
G
V
--------
A
F
Y
I
F
T
H
Q
G
S
----
D
----
F
--
G
P---
I
F
M
-
T
-
I
P
A
F
F
A
K
T
---
S
-
A
V
Y
N
P
V
I
--
Y
I
M
M
N
K
Q
------------
F
R
N
C
M
V
T
T
L
----------------
C
C
G
K
N
P
L
G
D
D
E
-------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
76.24
22%
-130
- C1 -
2I35
4
OPSD_BOVIN
A:
[49-317]
----------------------------------------------------------------------------
M
L
G
F
P
I
---
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
-
L
Y
T
S
L
H
G
Y
F
-
V
F
G
-
P
T
----
G
C
N
L
E
G
F
F
A
T
-----------------
L
G
G
E
I
A
L
----
W
S
L
V
V
L
A
I
E
R
Y
V
-----
V
V
C
K
P
M
S
-----
N
F
R
F
----------------------------
G
-----
E
N
H
A
I
M
G
V
A
F
-
T
W
V
M
A
L
-----
A
-----
C
A
A
P
--
P
L
--
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
H
E
E
T
-----------
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
-----
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
------------
A
---------------------
Q
---------
Q
Q
E
-
S
A
T
T
---
Q
K
---------------------
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
---
F
L
I
C
W
L
P
Y
A
G
V
--------
A
F
Y
I
F
T
H
Q
G
S
----
D
----
F
--
G
P---
I
F
M
-
T
-
I
P
A
F
F
A
K
T
---
S
-
A
V
Y
N
P
V
I
--
Y
I
M
M
N
K
Q
------------
F
R
N
C
M
V
T
T
L
----------------
C
C
G
K
N
D
D
E
----------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
76.24
22%
-135
- C1 -
4PXF
7
OPSD_BOVIN
A:
[49-317]
----------------------------------------------------------------------------
M
L
G
F
P
I
---
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
-
L
Y
T
S
L
H
G
Y
F
-
V
F
G
-
P
T
----
G
C
N
L
E
G
F
F
A
T
-----------------
L
G
G
E
I
A
L
----
W
S
L
V
V
L
A
I
E
R
Y
V
-----
V
V
C
K
P
M
S
-----
N
F
R
F
----------------------------
G
-----
E
N
H
A
I
M
G
V
A
F
-
T
W
V
M
A
L
-----
A
-----
C
A
A
P
--
P
L
--
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
H
E
E
T
-----------
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
-----
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
------------
A
---------------------
Q
---------
Q
Q
E
-
S
A
T
T
---
Q
K
---------------------
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
---
F
L
I
C
W
L
P
Y
A
G
V
--------
A
F
Y
I
F
T
H
Q
G
S
----
D
----
F
--
G
P
---
I
F
M
-
T
-
I
P
A
F
F
A
K
T
---
S
-
A
V
Y
N
P
V
I
--
Y
I
M
M
N
K
Q
------------
F
R
N
C
M
V
T
T
L
----------------
C
C
G
K
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
75.95
22%
-134
- C1 -
4J4Q
8
GNAT1_BOVIN (first)
A:
[49-317]
----------------------------------------------------------------------------
M
L
G
F
P
I
---
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
-
L
Y
T
S
L
H
G
Y
F
-
V
F
G
-
P
T
----
G
C
N
L
E
G
F
F
A
T
-----------------
L
G
G
E
I
A
L
----
W
S
L
V
V
L
A
I
E
R
Y
V
-----
V
V
C
K
P
M
S
-----
N
F
R
F
----------------------------
G
-----
E
N
H
A
I
M
G
V
A
F
-
T
W
V
M
A
L
-----
A
-----
C
A
A
P
--
P
L
--
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
H
E
E
T
-----------
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
-----
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
------------
A
---------------------
Q
---------
Q
Q
E
-
S
A
T
T
---
Q
K
---------------------
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
---
F
L
I
C
W
L
P
Y
A
G
V
--------
A
F
Y
I
F
T
H
Q
G
S
----
D
----
F
--
G
P
---
I
F
M
-
T
-
I
P
A
F
F
A
K
T
---
S
-
A
V
Y
N
P
V
I
--
Y
I
M
M
N
K
Q
------------
F
R
N
C
M
V
T
T
L
----------------
C
C
G
K
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
75.48
22%
-137
- C1 -
3PQR
9
OPSD_BOVIN
A:
[49-317]
----------------------------------------------------------------------------
M
L
G
F
P
I
---
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
-
L
Y
T
S
L
H
G
Y
F
-
V
F
G
-
P
T
----
G
C
N
L
E
G
F
F
A
T
-----------------
L
G
G
E
I
A
L
----
W
S
L
V
V
L
A
I
E
R
Y
V
-----
V
V
C
K
P
M
S
-----
N
F
R
F
----------------------------
G
-----
E
N
H
A
I
M
G
V
A
F
-
T
W
V
M
A
L
-----
A
-----
C
A
A
P
--
P
L
--
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
H
E
E
T
-----------
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
-----
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
------------
A
---------------------
Q
---------
Q
Q
E
-
S
A
T
T
---
Q
K
---------------------
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
---
F
L
I
C
W
L
P
Y
A
G
V
--------
A
F
Y
I
F
T
H
Q
G
S
----
D
----
F
--
G
P
---
I
F
M
-
T
-
I
P
A
F
F
A
K
T
---
S
-
A
V
Y
N
P
V
I
--
Y
I
M
M
N
K
Q
------------
F
R
N
C
M
V
T
T
L
----------------
C
C
G
K
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
75.11
22%
-137
- C1 -
3PXO
4
OPSD_BOVIN
A:
[49-317]
----------------------------------------------------------------------------
M
L
G
F
P
I
---
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
-
L
Y
T
S
L
H
G
Y
F
-
V
F
G
-
P
T
----
G
C
N
L
E
G
F
F
A
T
-----------------
L
G
G
E
I
A
L
----
W
S
L
V
V
L
A
I
E
R
Y
V
-----
V
V
C
K
P
M
S
-----
N
F
R
F
----------------------------
G
-----
E
N
H
A
I
M
G
V
A
F
-
T
W
V
M
A
L
-----
A
-----
C
A
A
P
--
P
L
--
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
H
E
E
T
-----------
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
-----
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
------------
A
---------------------
Q
---------
Q
Q
E
-
S
A
T
T
---
Q
K
---------------------
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
---
F
L
I
C
W
L
P
Y
A
G
V
--------
A
F
Y
I
F
T
H
Q
G
S
----
D
----
F
--
G
P
---
I
F
M
-
T
-
I
P
A
F
F
A
K
T
---
S
-
A
V
Y
N
P
V
I
--
Y
I
M
M
N
K
Q
------------
F
R
N
C
M
V
T
T
L
----------------
C
C
G
K
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
74.78
22%
-129
- C1 -
2I36
1
OPSD_BOVIN
A:
[49-317]
----------------------------------------------------------------------------
M
L
G
F
P
I
---
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
-
L
Y
T
S
L
H
G
Y
F
-
V
F
G
-
P
T
----
G
C
N
L
E
G
F
F
A
T
-----------------
L
G
G
E
I
A
L
----
W
S
L
V
V
L
A
I
E
R
Y
V
-----
V
V
C
K
P
M
S
-----
N
F
R
F
----------------------------
G
-----
E
N
H
A
I
M
G
V
A
F
-
T
W
V
M
A
L
-----
A
-----
C
A
A
P
--
P
L
--
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
H
E
E
T
-----------
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
-----
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
------------
A
---------------------
Q
---------
Q
Q
E
-
S
A
T
T
---
Q
K
---------------------
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
---
F
L
ICWLP
Y
A
G
V
--------
A
F
Y
I
F
T
H
Q
G
S
----
D
----
F
--
G
P---
I
F
M
-
T
-
I
P
A
F
F
A
K
T
---
S
-
A
V
Y
N
P
V
I
--
Y
I
M
M
N
K
Q
------------
F
R
N
C
M
V
T
T
L
----------------
C
C
G
K
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
74.77
16%
-130
- C1 -
1U19
14
OPSD_BOVIN
A:
[41-328]
-----------------------------------------------------------
S
M
L
A
A
Y
M
F
------
L
L
I
M
L
G
F
P
I
---
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
----
F
M
V
F
G
G
-
F
T
T
T
L
Y
T
S
L
-
H
G
Y
-
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
-----------------
L
G
G
E
I
A
L
----
W
S
L
V
V
L
A
I
E
R
Y
V
-----
V
V
C
K
P
M
S
N
F
R
-
F
G
E
N
H
A
I
M
G
V
-----------------
A
F
T
W
V
M
A
-----
L
A
C
A
-
A
P
P
L
V
-
G
W
S
R
Y
I
-----
P
-----------
E
G
--
M
Q
C
S
C
G
I
D
Y
Y
T
P
---
H
E
E
T
N
N
E
S
F
V
I
-----------
Y
M
F
V
V
H
F
I
I
P
L
I
V
I
F
F
C
-----
Y
G
Q
L
------
V
F
T
V
K
E
A
A
A
------------
Q
---------------------
Q
QESA
T
T
Q
K
A
E
K
E
-
V
T
R
M
---
V
I
---------------------
I
M
--------
V
I
A
F
L
---
I
------
C
W
L
P
--------
Y
A
G
V
A
F
Y
I
F
T
H
QGS
D
----
F
--
G
P---
I
F
M
-
T
-
I
P
A
F
F
A
K
T
---
S
-
A
V
Y
N
P
V
I
--
Y
I
M
M
N
K
Q
------------
F
R
N
C
M
V
T
T
L
----------------
C
C
G
K
N
P
L
G
D
D
E
-------------------------------------------------------------------------------------------------------------------------------------------------------
45
Fugue
74.60
19%
-163
- C1 -
4R33
5
?
A:
[35-418]
-------G
D
F
V
L
P
E
L
E
D
V
R
A
E
A
A
T
V
D
T
R
A
V
L
A
L
A
E
GEEPAE
S
R
A
A
-------------
V
A
L
A
L
W
E
D
R
------
S
I
G
T
A
E
L
Q
A
---
A
A
E
A
R
C
G
A
R
-
R
P
R
L
H
T
F
V
P
L
Y
T
T
N
Y
---------
C
D
S
E
C
K
-
M
C
S
M
R
K
G
N
H
R
L
D
R
-
K
F
S
G
R
K
E
I
T
E
Q
L
E
I
L
Y
HHEGVR
G
V
G
F
L
T
G
E
Y
E
D
K
H
T
R
L
A
S
----
A
F
R
I
G
W
A
I
R
T
A
L
-----
D
L
G
F
E
R
V
Y
F
N
I
G
S
M
E
Q
D
E
I
D
V
-----------------
L
G
E
W
I
G
R
EDP
V
-
T
M
C
V
-
F
Q
E
S
Y
D
R
E
T
Y
R
R
-----
F
-----
M
G
K
T
--
S
V
--
G
V
P
K
A
D
--
F
D
R
R
V
V
S
F
D
R
W
L
D
A
----------------
G
Y
R
Y
V
N
P
G
V
L
V
G
L
H
D
D
-----
L
S
A
E
------
L
V
S
L
V
A
H
G
D
------------
H
---------------------
L
---------
R
S
R
G
A
T
A
D
---
L
S
VPRMRPAMKS
R
D
T
T
R
V
G
D
D
D
Y
L
R
--------
L
M
S
V
V
---
A
------
F
T
C
P
E
Q
------
R
L
V
L
T
T
R
E
P
Q
----
E
----
F
--------
Q
D
-
V
-
A
L
G
L
A
G
V
I
S
P
G
S
-
P
D
V
A
P
Y
R
AG
C
E
A
R
N
D
E
KSSQFLVADLRR
P
R
H
I
L
G
R
I
E
----------------
A
S
G
T
P
V
D
H
F
V
N
PAGEASR------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
74.57
22%
-118
- C1 -
1HZX
14
OPSD_BOVIN
A:
[52-318]
----------------------------------------------------------------------------
M
L
G
F
P
I
---
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
-
L
Y
T
S
L
H
G
Y
F
-
V
F
G
-
P
T
----
G
C
N
L
E
G
F
F
A
T
-----------------
L
G
G
E
I
A
L
----
W
S
L
V
V
L
A
I
E
R
Y
V
-----
V
V
C
K
P
M
S
-----
N
F
R
F
----------------------------
G
-----
E
N
H
A
I
M
G
V
A
F
-
T
W
V
M
A
L
-----
A
-----
C
A
A
P
--
P
L
--
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
H
E
E
T
-----------
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
-----
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
------------
A
------------------------------------
A
T
T
---
Q
K
---------------------
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
---
F
L
I
C
W
L
P
Y
A
G
V
--------
A
F
Y
I
F
T
H
Q
G
S
----
D
----
F
--
G
P---
I
F
M
-
T
-
I
P
A
F
F
A
K
T
---
S
-
A
V
Y
N
P
V
I
--
Y
I
M
M
N
K
Q
------------
F
R
N
C
M
V
T
T
L
----------------
C
C
G
K
N
P
L
G
D
S
T
-------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
74.44
22%
-137
- C1 -
3CAP
4
OPSD_BOVIN
A:
[49-317]
----------------------------------------------------------------------------
M
L
G
F
P
I
---
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
G
F
T
T
T
-
L
Y
T
S
L
H
G
Y
F
-
V
F
G
-
P
T
----
G
C
N
L
E
G
F
F
A
T
-----------------
L
G
G
E
I
A
L
----
W
S
L
V
V
L
A
I
E
R
Y
V
-----
V
V
C
K
P
M
S
-----
N
F
R
F
----------------------------
G
-----
E
N
H
A
I
M
G
V
A
F
-
T
W
V
M
A
L
-----
A
-----
C
A
A
P
--
P
L
--
V
G
W
S
R
Y
I
P
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
H
E
E
T
-----------
N
N
E
S
F
V
I
Y
M
F
V
V
H
F
I
I
P
-----
L
I
V
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
------------
A
---------------------
Q
---------
Q
Q
E
-
S
A
T
T
---
Q
K
---------------------
A
E
K
E
V
T
R
M
V
I
I
M
V
I
A
---
F
L
I
C
W
L
P
Y
A
G
V
--------
A
F
Y
I
F
T
H
Q
G
S
----
D
----
F
--
G
P
---
I
F
M
-
T
-
I
P
A
F
F
A
K
T
---
S
-
A
V
Y
N
P
V
I
--
Y
I
M
M
N
K
Q
------------
F
R
N
C
M
V
T
T
L
----------------
C
C
G
K
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------
44
Fugue
74.40
14%
-134
- C1 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
-----------------------------------------
D
E
V
W
-------------
V
V
G
M
G
I
V
M
S
------
L
I
V
L
A
I
V
F
G
---
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
----
V
M
G
L
A
V
-
V
P
F
G
A
A
H
I
L
-
M
K
M
-
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
-----------------
L
C
V
T
A
S
I
----
E
T
L
C
V
I
A
V
D
R
Y
F
-----
A
I
T
S
P
F
K
Y
Q
S
L
L
T
K
N
K
A
R
V
I
I
-----------------
L
M
V
W
I
V
S
-----
G
L
T
S
-
F
L
P
I
Q
-
M
-----------------
H
W
Y
--
R
A
--
T
H
Q
E
A
I
N
C
Y
A
E
E
T
C
C
D
F
F
T
N
Q
A
Y
A
I
A
-----------
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
Y
-----
S
R
V
F
------
Q
E
A
K
R
Q
L
N
I
------------
F
---------------------
E
---------
M
L
R
-
I
D
E
G
---
L
R
---------------------
L
K
--------
I
Y
K
D
T
EGY
Y
------
T
I
G
I
--------
G
H
L
L
T
K
S
P
S
L
----
N
----
A
--
A
----
K
S
E
-
L
-
D
K
A
I
G
R
N
T
---
N
G
V
I
T
K
D
E
A
--
E
K
L
F
N
Q
D
------------
V
D
A
A
V
R
G
I
L
----------------
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAYKFCL
K
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
QDNLIR
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
PLIYCRS
P
D
F
R
I
A
F
Q
E
L
L
CL