@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : OR4M1_HUMAN: (2016-01-13 )
METANYTKVTEFVLTGLSQTREVQLVLFVIFLSFYLFILPGNILIICTIRLDPHLTSPMYFLLANLALLDIWYSSITAPKMLIDFFVERKIISFGGCIAQLFFLHFVGASEMFLLTVMAYDRYAAICRPLHYATIMNRRLCCILVALSWMGGFIHSIIQVALIVRLPFCGPNELDSYFCDITQVVRIACANTFPEELVMICSSGLISVVCFIALLMSYAFLLALLKKHSGSGENTNRAMSTCYSHITIVVLMFGPSIYIYARPFDSFSLDKVVSVFHTVIFPLLNPIIYTLRNKEVKAAMRKVVTKYILCEEK
Atome Classification :
(20 SA)
-------------------....-..--------------...10........20---------------.------........---------30..-----------......-----40-........50-------.........60.------.......70.-..----...-..-80.....-...90.....--....--------100.--......110...---....120.......130...---....140.......---------------150.......160-....-..-----.-.170.......180....-------...190.--.-.....200.----------------------------.....-----..210-----.....-----..220....---...230---------.---------------------------.-------.---.....240.-----------------------------......250.--------......260...-------.----.-------.---.270--------........280..-.......290....--------...300-..------------------.....310----...------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-------------------META-
N
Y
--------------
T
K
V
T
E
F
V
L
TGLSQT----------------
R
------
E
V
Q
L
V
L
F
V
---------
I
F
L
S
-----------
F
Y
L
F
IL-----PG-
N
I
L
I
I
C
T
I
R
--------LDPHLT
S
P
M
Y
F
L
------
L
A
N
L
A
L
L
D
I
W
-
Y
S
----SIT-
A
P
-
K
M
L
I
D
F
F
-
V
E
R
K
-
I
I
S
F
G
--
G
C
I
A
--------
Q
L
F
F
--
L
H
FVGAS
E
M
F
L
L
---
T
V
M
A
Y
D
R
Y
A
A
I
C
R
P
L
H
Y
A
T
I
---
M
NR
R
L
C
C
I
L
V
A
L
S
W
---------------
M
G
G
F
I
H
S
I
I
Q
V
A
--
L
I
VR-LP-----F-CG
P
N
E
L
D
S
Y
F
C
D
I
T
Q
V
V
R
-------
I
A
C
ANT
F
--
P
-
E
E
L
V
M
I
-
C
S----------------------------S
G
L
I
S
-----
V
V
C
F
I
-----
A
L
L
M
S
-----
Y
A
F
L
L
A
L
L
K
---KHSGS----------G---------------------------E-------N---T
N
R
A
M
S
T
C
Y
-----------------------------
S
H
I
T
I
V
V
L
M
F--------G
P
S
I
Y
I
Y
A
RPFD-------S----F-------
S
---
L
D
K
---------
V
V
S
V
F
H
T
V
I
--
F
P
-
L
L
N
P
I
I
Y
T
LR
N
K
E
V
--------
K
A
A
M
R
K
-
V
V
------------------
T
K
Y
I
LC------EEK------------
33
HHSearch
86.08
17%
-149
- C3 -
2Z73
5
OPSD_TODPA
A:
[32-335]
-----------------------------------------------------------------------------
A
V
Y
Y
S
L
G
I
---------
F
I
G
I
-----------
C
G
I
I
G
C
-----
G
G
-
N
G
I
V
I
Y
L
F
T
--------
K
T
K
S
L
Q
T
P
A
N
M
F
------
I
I
N
L
A
F
S
D
F
T
-
F
S
----
L
V
N
G
F
P
-
L
M
T
I
S
C
F
-
L
K
K
W
-
I
F
G
F
A
--
A
C
K
V
--------
Y
G
F
I
--
G
G
I
F
G
F
M
S
I
M
T
M
---
A
M
I
S
I
D
R
Y
N
V
I
G
R
P
M
A
A
S
K
K
---
M
S
H
R
R
A
F
I
M
I
I
F
V
W
---------------
L
W
S
V
L
W
A
I
G
P
I
F
--
G
W
G
A
-
Y
T
-----
L
-----
E
G
V
L
C
N
C
S
F
D
Y
I
S
------------
R
D
S
--
T
-
T
R
S
N
I
L
-
C
M
----------------------------
F
I
L
G
F
-----
F
G
P
I
L
-----
I
I
F
F
C
-----
Y
F
N
I
V
M
S
V
S
---
N
H
E
K
E
----------
M
A
A
M
A
K
RLNAKE
L
R
K
A
Q
A
G
A
--------
N
-------
A
---
E
M
R
L
A
K
I
S
I
-----------------------------
V
I
V
S
Q
F
L
L
S
W
--------
S
P
Y
A
V
V
A
L
L
A
Q
F
-------
G
PLE-
W
VT-----
P
---
Y
A
A
---------
Q
L
P
V
M
F
A
K
A
--
S
A
-
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
--------
R
E
A
I
S
Q
-
T
F
------------------
P
W
V
L
T
C
------
C
Q
F
------------
40
Fugue
85.18
18%
-131
- C3 -
1F88
8
OPSD_BOVIN
A:
[1-348]
----------------------
M
-
N
G
--------------
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
GVVRSPFEAPQYYLAE
P
------
W
Q
F
S
M
L
A
A
---------
Y
M
F
L
-----------
L
I
M
L
G
F
-----
P
I
-
N
F
L
T
L
Y
V
T
V
--------
Q
H
K
K
L
R
T
P
L
N
Y
I
------
L
L
N
L
A
V
A
D
L
F
-
M
V
----
F
G
G
-
F
T
-
T
T
L
Y
T
S
L
-
H
G
Y
F
-
V
F
G
P
T
--
G
C
N
L
--------
E
G
F
F
--
A
T
L
G
G
E
I
A
L
W
S
L
---
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
----
F
G
E
N
H
A
I
M
G
V
A
F
T
W
---------------
V
M
A
L
A
C
A
A
P
P
L
V
--
G
W
S
R
-
Y
I
-----
P
-
E
G
M
Q
--
C
S
C
G
I
D
Y
Y
T
P
H
E
-------
E
T
N
N
E
S
F
--
V
-
I
Y
M
F
V
V
-
H
F
----------------------------
I
I
P
L
I
-----
V
I
F
F
C
-----
Y
G
Q
-----------
L
V
F
T
V
---
K
E
A
A
A
----------
S
---------------------------
A
-------
T
---
T
Q
K
A
E
K
E
V
T
-----------------------------
R
M
V
I
I
M
V
I
A
F
--------
L
I
C
W
L
P
Y
A
G
V
A
F
-------
Y
----
I
-------
F
---
T
H
Q
GSDFGPIFM
T
I
P
A
F
F
A
K
T
--
S
A
-
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
--------
R
N
C
M
V
T
-
T
L
------------------
C
C
G
K
N
P
------
S
T
T
VSKTETS
Q
V
A
P
A
17
PsiBlast_PDB
84.30
22%
-143
- C3 -
1F88
7
OPSD_BOVIN
A:
[40-317]
------------------------------------------------------------------------------------------------
L
A
-----------
A
Y
M
F
L
L
I
M
L
G
F
P
I
-
N
F
L
T
L
Y
V
T
V
--------
Q
H
K
K
L
R
T
P
L
N
Y
I
------
L
L
N
L
A
V
A
D
L
F
-
M
V
F
GG
F
T
T
T
-
L
Y
-
T
S
L
H
G
Y
F
-
V
-------
F
G
P
T
G
C
N
L
--------
E
G
F
F
--
A
T
L
G
G
E
I
A
L
W
S
L
---
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
--------
N
F
R
F
--------------------------
G
E
N
H
A
I
M
G
V
A
--
F
T
W
V
-
M
A
-----
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
-------
C
S
C
G
I
D
Y
YT
P
-
H
E
E
T
N
N
-
E
S
----------------------------
F
V
I
Y
M
F
V
VHF
I
I
P
L
I
-----
V
I
F
F
C
-----
Y
G
Q
L
V
F
T
V
K
---
E
A
A
A
------------------------------------------------SAT
T
Q
K
A
E
K
E
V
T
-----------------------------
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
-------
D
----
F
-------
G
P--
I
F
M
---------
T
I
P
A
F
F
A
K
T
--
S
A
-
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
--------
R
N
C
M
V
T
-
T
L
------------------
C
C
G
K
N
P
------
S
T
T
------------
41
Fugue
83.14
19%
-138
- C3 -
1U19
15
OPSD_BOVIN
A:
[4-349]
-----MN
G
T
E
G
PNFYVPFS
N
K
T
G
-
V
V
--------------
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
P
----------------
W
------
Q
F
S
M
L
A
A
Y
---------
M
F
L
------------
L
I
M
L
G
F
-----
P
I
-
N
F
L
T
L
Y
V
T
V
--------
Q
H
K
K
L
R
T
P
L
N
Y
I
------
L
L
N
L
A
V
A
D
L
F
-
M
V
----
F
G
G
-
F
T
-
T
T
L
Y
T
S
L
-
H
G
Y
F
-
V
F
G
P
T
--
G
C
N
L
--------
E
G
F
F
--
A
T
L
G
G
E
I
A
L
W
S
L
---
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
----
F
G
E
N
H
A
I
M
G
V
A
F
T
W
---------------
V
M
A
L
A
C
A
A
P
P
L
V
--
G
W
S
R
Y
I
P
E
GMQC
S
-
C
G
I
D
----
Y
Y
T
P
----------------
H
E
E
T
--
N
-
N
E
S
F
V
I
-
Y
M
----------------------------
F
V
V
H
F
-----
I
I
P
L
I
-----
V
I
F
F
C
-----
Y
G
Q
L
V
F
T
V
K
EAA
A
Q
Q
Q
E
----------
S
---------------------------
A
-------
T
---
T
Q
K
A
E
K
E
V
T
-----------------------------
R
M
V
I
I
M
V
I
A
F
--------
L
I
C
W
L
P
Y
A
G
V
A
F
-------
Y
----
I
-------
F
---
T
H
Q
GSDFGPIFM
T
I
P
A
F
F
A
K
T
--
S
A
-
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
--------
R
N
C
M
V
T
-
T
L
C
CGKNPLGDDEA
S
T
T
V
S
K
T
E
T
S
Q
V
------
A
P
A
------------
16
PsiBlast_PDB
81.84
22%
-147
- C3 -
3C9L
13
OPSD_BOVIN
A:
[40-317]
------------------------------------------------------------------------------------------------
L
A
-----------
A
Y
M
F
L
L
I
M
L
G
F
P
I
-
N
F
L
T
L
Y
V
T
V
--------
Q
H
K
K
L
R
T
P
L
N
Y
I
------
L
L
N
L
A
V
A
D
L
F
-
M
V
F
G
G
F
T
T
T
-
L
Y
-
T
S
L
H
G
Y
F
-
V
-------
F
G
P
T
G
C
N
L
--------
E
G
F
F
--
A
T
L
G
G
E
I
A
L
W
S
L
---
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
--------
N
F
R
F
--------------------------
G
E
N
H
A
I
M
G
V
A
--
F
T
W
V
-
M
A
-----
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
-------
C
S
C
G
I
D
Y
YT
P
-
H
E
E
T
N
N
-
E
S
----------------------------
F
V
I
Y
M
F
V
VHF
I
I
P
L
I
-----
V
I
F
F
C
-----
Y
G
Q
L
V
F
T
V
K
---
E
A
A
A
Q
----------
Q
---------------------------
Q
-------
E
S
A
T
T
Q
K
A
E
K
E
V
T
-----------------------------
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
-------
D
----
F
-------
G
P--
I
F
M
---------
T
I
P
A
F
F
A
K
T
--
S
A
-
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
--------
R
N
C
M
V
T
-
T
L
------------------
C
C
G
K
N
D
------
D
E
-------------
18
PsiBlast_PDB
80.16
22%
-150
- C3 -
3DQB
4
GNAT1_BOVIN (first)
A:
[40-317]
------------------------------------------------------------------------------------------------
L
A
-----------
A
Y
M
F
L
L
I
M
L
G
F
P
I
-
N
F
L
T
L
Y
V
T
V
--------
Q
H
K
K
L
R
T
P
L
N
Y
I
------
L
L
N
L
A
V
A
D
L
F
-
M
V
F
GG
F
T
T
T
-
L
Y
-
T
S
L
H
G
Y
F
-
V
-------
F
G
P
T
G
C
N
L
--------
E
G
F
F
--
A
T
L
G
G
E
I
A
L
W
S
L
---
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
--------
N
F
R
F
--------------------------
G
E
N
H
A
I
M
G
V
A
--
F
T
W
V
-
M
A
-----
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
-------
C
S
C
G
I
D
Y
YT
P
-
H
E
E
T
N
N
-
E
S
----------------------------
F
V
I
Y
M
F
V
VHF
I
I
P
L
I
-----
V
I
F
F
C
-----
Y
G
Q
L
V
F
T
V
K
---
E
A
A
A
Q
----------
Q
---------------------------
Q
-------
E
S
A
T
T
Q
K
A
E
K
E
V
T
-----------------------------
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
-------
D
----
F
-------
G
P
--
I
F
M
---------
T
I
P
A
F
F
A
K
T
--
S
A
-
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
--------
R
N
C
M
V
T
-
T
L
------------------
C
C
G
K
N
----------------------
48
Fugue
79.45
17%
-136
- C3 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
---------------------------------------------
S
F
K
C
A
L
T
K
T
----------------
G
------
F
Q
F
Y
Y
L
P
A
---------
V
Y
I
L
-----------
V
F
I
I
G
F
-----
L
G
-
N
S
V
A
I
W
M
F
V
--------
F
H
M
K
P
W
S
G
I
S
V
Y
------
M
F
N
L
A
L
A
D
F
L
-
Y
V
-----
L
T
-
L
P
-
A
L
I
F
Y
Y
F
-
N
K
T
D
W
I
F
G
D
A
--
M
C
K
L
--------
Q
R
F
I
--
F
H
V
N
L
Y
G
S
I
L
F
L
---
T
C
I
S
A
H
R
Y
S
G
V
V
Y
P
K
S
L
G
R
L
---
K
K
K
N
A
I
C
I
S
V
L
V
W
L
---------------
I
V
V
V
A
I
S
P
I
L
F
Y
S
G
T
G
V
R
-
K
N
KTI--
T
-
C
Y
D
T
T
S
D
E
Y
L
R
S
Y
F
I
Y
S
M
-------
C
T
T
V
A
M
F
--
C
-
V
P
L
V
L
I
-
L
G
----------------------------
C
Y
G
L
I
-----
V
R
A
L
I
-----
Y
K
M
K
K
-----
Y
T
C
T
V
C
G
Y
I
---
Y
N
P
E
D
----------
G
DPDNGVNPGTDFKDIVCPLCGVGKDQ
F
E
-------
E
---
V
E
E
P
L
R
R
K
S
-----------------------------
I
Y
L
V
I
I
V
L
T
V
--------
F
A
V
S
Y
I
P
F
H
V
M
K
-------
T
----
M
-------
N
---
L
R
A
---------
R
L
D
F
Q
T
P
A
M
--
C
A
-
F
N
D
R
V
Y
A
T
Y
Q
V
T
R
G
--------
L
A
S
L
N
S
-
C
V
------------------
N
P
I
L
Y
F
LAGDTF
R
R
R
------------
32
HHSearch
79.24
14%
-149
- C3 -
2KS9
1
NK1R_HUMAN
A:
[34-325]
---------------------------------------------------------------------------------
L
W
A
A
---------
A
Y
T
V
-----------
I
V
V
T
S
V
-----
V
G
-
N
V
V
V
M
W
I
I
L
--------
A
H
K
R
M
R
T
V
T
N
Y
F
------
L
V
N
L
A
F
A
E
A
S
-
M
A
----
A
F
N
-
T
V
-
V
N
F
T
Y
A
V
-
H
N
E
W
-
Y
Y
G
L
F
--
Y
C
K
F
--------
H
N
F
F
--
P
I
A
A
V
F
A
S
I
Y
S
M
---
T
A
V
A
F
D
R
Y
M
A
I
I
H
P
L
Q
P
R
L
-----
S
A
T
A
T
K
V
V
I
C
V
I
W
---------------
V
L
A
L
L
L
A
F
P
Q
G
Y
--
Y
S
T
T
-
E
T
-----
M
------
P
S
R
V
V
C
M
I
E
W
P
E
H
----------
P
N
K
I
--
Y
-
E
K
V
Y
H
I
-
C
V
----------------------------
T
V
L
I
Y
-----
F
L
P
L
L
-----
V
I
G
Y
A
-----
Y
T
V
V
G
I
T
L
W
---
A
S
E
I
P
GDSSDRYH
E
Q
V
---------------------------
S
-------
A
---
K
R
K
V
V
K
M
M
I
-----------------------------
V
V
V
C
T
F
A
I
C
W
--------
L
P
F
H
I
F
F
L
L
P
Y
I
-------
N
PDLY
L
K------
K
FI
Q
Q
V
Y
---------
L
A
I
M
W
L
A
M
S
--
S
T
-
M
Y
N
P
I
I
Y
C
C
L
N
D
R
F
--------
R
L
G
F
K
H
-
A
F
------------------
R
C
C
P
F
I
------
S
A
G
------------
19
PsiBlast_PDB
79.03
22%
-148
- C3 -
3PQR
9
OPSD_BOVIN
A:
[40-317]
------------------------------------------------------------------------------------------------
L
A
-----------
A
Y
M
F
L
L
I
M
L
G
F
P
I
-
N
F
L
T
L
Y
V
T
V
--------
Q
H
K
K
L
R
T
P
L
N
Y
I
------
L
L
N
L
A
V
A
D
L
F
-
M
V
FGG
F
T
T
T
-
L
Y
-
T
S
L
H
G
Y
F
-
V
-------
F
G
P
T
G
C
N
L
--------
E
G
F
F
--
A
T
L
G
G
E
I
A
L
W
S
L
---
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
--------
N
F
R
F
--------------------------
G
E
N
H
A
I
M
G
V
A
--
F
T
W
V
-
M
A
-----
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
-------
C
S
C
G
I
D
Y
YT
P
-
H
E
E
T
N
N
-
E
S
----------------------------
F
V
I
Y
M
F
V
VHF
I
I
P
L
I
-----
V
I
F
F
C
-----
Y
G
Q
L
V
F
T
V
K
---
E
A
A
A
Q
----------
Q
---------------------------
Q
-------
E
S
A
T
T
Q
K
A
E
K
E
V
T
-----------------------------
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
-------
D
----
F
-------
G
P
--
I
F
M
---------
T
I
P
A
F
F
A
K
T
--
S
A
-
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
--------
R
N
C
M
V
T
-
T
L
------------------
C
C
G
K
N
----------------------
15
PsiBlast_PDB
78.95
22%
-148
- C3 -
3CAP
4
OPSD_BOVIN
A:
[40-317]
------------------------------------------------------------------------------------------------
L
A
-----------
A
Y
M
F
L
L
I
M
L
G
F
P
I
-
N
F
L
T
L
Y
V
T
V
--------
Q
H
K
K
L
R
T
P
L
N
Y
I
------
L
L
N
L
A
V
A
D
L
F
-
M
V
F
GG
F
T
T
T
-
L
Y
-
T
S
L
H
G
Y
F
-
V
-------
F
G
P
T
G
C
N
L
--------
E
G
F
F
--
A
T
L
G
G
E
I
A
L
W
S
L
---
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
--------
N
F
R
F
--------------------------
G
E
N
H
A
I
M
G
V
A
--
F
T
W
V
-
M
A
-----
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
-------
C
S
C
G
I
D
Y
YT
P
-
H
E
E
T
N
N
-
E
S
----------------------------
F
V
I
Y
M
F
V
VHF
I
I
P
L
I
-----
V
I
F
F
C
-----
Y
G
Q
L
V
F
T
V
K
---
E
A
A
A
Q
----------
Q
---------------------------
Q
-------
E
S
A
T
T
Q
K
A
E
K
E
V
T
-----------------------------
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
-------
D
----
F
-------
G
P
--
I
F
M
---------
T
I
P
A
F
F
A
K
T
--
S
A
-
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
--------
R
N
C
M
V
T
-
T
L
------------------
C
C
G
K
N
----------------------
20
PsiBlast_PDB
78.22
22%
-147
- C3 -
3PXO
4
OPSD_BOVIN
A:
[40-317]
------------------------------------------------------------------------------------------------
L
A
-----------
A
Y
M
F
L
L
I
M
L
G
F
P
I
-
N
F
L
T
L
Y
V
T
V
--------
Q
H
K
K
L
R
T
P
L
N
Y
I
------
L
L
N
L
A
V
A
D
L
F
-
M
V
F
G
G
F
T
T
T
-
L
Y
-
T
S
L
H
G
Y
F
-
V
-------
F
G
P
T
G
C
N
L
--------
E
G
F
F
--
A
T
L
G
G
E
I
A
L
W
S
L
---
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
--------
N
F
R
F
--------------------------
G
E
N
H
A
I
M
G
V
A
--
F
T
W
V
-
M
A
-----
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
-------
C
S
C
G
I
D
Y
YT
P
-
H
E
E
T
N
N
-
E
S
----------------------------
F
V
I
Y
M
F
V
VHF
I
I
P
L
I
-----
V
I
F
F
C
-----
Y
G
Q
L
V
F
T
V
K
---
E
A
A
A
Q
----------
Q
---------------------------
Q
-------
E
S
A
T
T
Q
K
A
E
K
E
V
T
-----------------------------
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
-------
D
----
F
-------
G
P
--
I
F
M
---------
T
I
P
A
F
F
A
K
T
--
S
A
-
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
--------
R
N
C
M
V
T
-
T
L
------------------
C
C
G
K
N
----------------------
13
PsiBlast_PDB
77.31
22%
-136
- C3 -
2X72
5
GNAT1_BOVIN (first)
A:
[43-318]
------------------------------------------------------------------------------------------------
L
A
-----------
A
Y
M
F
L
L
I
M
L
G
F
P
I
-
N
F
L
T
L
Y
V
T
V
--------
Q
H
K
K
L
R
T
P
L
N
Y
I
------
L
L
N
L
A
V
A
D
L
F
-
M
V
F
GG
F
T
T
T
-
L
Y
-
T
S
L
H
G
Y
F
-
V
-------
F
G
P
T
G
C
N
L
--------
Q
G
F
F
--
A
T
L
G
G
E
I
A
L
W
S
L
---
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
--------
N
F
R
F
--------------------------
G
E
N
H
A
I
M
G
V
A
--
F
T
W
V
-
M
A
-----
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
-------
C
S
C
G
I
D
Y
YT
P
-
H
E
E
T
N
N
-
E
S
----------------------------
F
V
I
Y
M
F
V
VHF
I
I
P
L
I
-----
V
I
F
F
C
-----
Y
G
Q
L
V
F
T
V
K
---
E
A
A
A
Q
----------
Q
---------------------------
Q
-------
E
S
A
T
T
Q
K
A
E
K
E
V
T
-----------------------------
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
-------
C
----
F
-------
G
P
--
I
F
M
---------
T
I
P
A
F
F
A
K
T
--
S
A
-
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
--------
R
N
C
M
V
T
-
T
L
------------------
C
C
G
K
N
----------------------
30
HHSearch
77.24
20%
-131
- C3 -
2LNL
-
CXCR1_HUMAN
A:
[37-323]
-----------------------------------------------------------------------------
L
N
K
Y
V
V
I
I
---------
A
Y
A
L
-----------
V
F
L
L
S
L
-----
L
G
-
N
S
L
V
M
L
V
I
L
--------
Y
S
R
V
G
R
S
V
T
D
V
Y
------
L
L
N
L
A
L
A
D
L
L
-
F
A
----
L
T
--
L
P
-
I
W
A
A
S
K
--
V
N
G
W
-
I
F
G
T
F
--
L
C
K
V
--------
V
S
L
L
--
K
E
V
N
F
Y
S
G
I
L
L
L
---
A
C
I
S
V
D
R
Y
L
A
I
V
H
A
T
R
T
L
T
----
Q
K
R
H
L
V
K
F
V
C
L
G
C
W
---------------
G
L
S
M
N
L
S
L
P
F
F
L
--
F
R
Q
A
-
Y
H
-----
P
-----
N
N
S
S
P
V
C
Y
E
V
L
G
N
-----------
D
T
A
K
--
W
-
R
M
V
L
R
I
-
L
P
----------------------------
H
T
F
G
F
-----
I
V
P
L
F
-----
V
M
L
F
C
-----
Y
G
F
T
L
R
T
L
F
---
K
A
H
------------
M
---------------------------
G
-------
Q
---
K
H
R
A
M
R
V
I
F
-----------------------------
A
V
V
L
I
F
L
L
C
W
--------
L
P
Y
N
L
V
L
L
A
D
T
L
M
RTQVIQ
E
----
S
C
E
R
R
N
N
I
G
---
R
A
L
---------
D
A
T
E
I
L
G
F
L
--
H
S
-
C
L
N
P
I
I
Y
A
F
I
G
Q
N
F
--------
R
H
G
F
L
K
-
I
L
------------------
A
M
H
G
-----------------------
31
HHSearch
76.94
17%
-147
* C3 *
1U19
14
OPSD_BOVIN
A:
[41-328]
--------------------------------------------------------------------------------
S
M
L
A
A
---------
Y
M
F
L
-----------
L
I
M
L
G
F
-----
P
I
-
N
F
L
T
L
Y
V
T
V
--------
Q
H
K
K
L
R
T
P
L
N
Y
I
------
L
L
N
L
A
V
A
D
L
F
-
M
V
----
F
G
G
-
F
T
-
T
T
L
Y
T
S
L
-
H
G
Y
F
-
V
F
G
P
T
--
G
C
N
L
--------
E
G
F
F
--
A
T
L
G
G
E
I
A
L
W
S
L
---
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
N
F
R
F
----
G
E
N
H
A
I
M
G
V
A
F
T
W
---------------
V
M
A
L
A
C
A
A
P
P
L
V
--
G
W
S
R
-
Y
I
-----
P
-----
E
G
M
Q
C
S
C
G
I
D
Y
Y
T
P
----------
H
E
E
T
--
N
-
N
E
S
F
V
I
-
Y
M
----------------------------
F
V
V
H
F
-----
I
I
P
L
I
-----
V
I
F
F
C
-----
Y
G
Q
L
V
F
T
V
K
---
E
A
A
A
Q
----------
Q
---------------------------
Q
ESA
T
T
Q
K
A
---
E
K
E
V
T
R
M
V
I
-----------------------------
I
M
V
I
A
F
L
I
C
W
--------
L
P
Y
A
G
V
A
F
Y
I
F
T
H
Q-----
G
----
S
DFG----
P
---
I
F
M
---------
T
I
P
A
F
F
A
K
T
--
S
A
-
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
--------
R
N
C
M
V
T
-
T
L
------------------
C
C
G
K
N
P
------
L
G
D
------------
14
PsiBlast_PDB
73.07
22%
-128
- C3 -
1LN6
1
OPSD_BOVIN
A:
[40-315]
------------------------------------------------------------------------------------------------
L
A
-----------
A
Y
M
F
L
L
IMLGF
P
I
-
N
F
L
T
L
Y
V
T
V
--------
Q
H
K
K
L
R
T
P
L
N
Y
I
------
L
L
N
L
A
V
A
D
L
F
-
M
V
FGGF
T
T
T
-
L
Y
-
T
S
L
H
G
Y
F
-
V
-------
F
G
PT
G
C
N
L
--------
E
G
F
F
--
A
T
L
G
G
E
I
A
L
W
S
L
---
V
V
L
A
I
E
R
Y
V
V
V
C
K
P
M
S
--------
N
F
R
F
--------------------------
G
E
N
H
A
I
M
G
V
A
--
F
T
W
V
-
M
A
-----
L
A
C
A
A
P
P
L
V
G
W
S
R
Y
I
P
E
G
M
Q
-------
C
S
C
G
I
D
Y
YT
P
-
H
E
E
T
N
N
-
E
S
----------------------------
F
V
I
Y
M
FVVHF
I
I
P
L
I
-----
V
I
F
F
C
-----
Y
G
Q
L
V
F
T
V
K
---
E
A
A
A
Q
----------
Q
---------------------------
Q
-------
E
SAT
T
Q
K
A
E
K
E
V
T
-----------------------------
R
M
V
I
I
M
V
I
A
F
LICWLP
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
-------
D
----
F
-------
G
P--
I
F
M
---------
T
I
P
A
F
F
A
K
T
--
S
A
-
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
--------
R
N
C
M
V
V
-
A
T
------------------
T
L
C
C
G
K
------
N
P
L
------------
47
Fugue
72.16
15%
-151
- C1 -
1A6Q
3
PPM1A_HUMAN
A:
[2-368]
-----------GAFLDKPK
M
E
K
H
-
N
A
--------------
Q
G
Q
G
N
G
L
R
Y
G
L
S
S
M
----------------
Q
GWRVEM
E
D
A
H
T
A
V
I
G
LPSGLES
W
S
F
F
A
-----------
V
Y
D
G
H
A
-----
G
S
-
Q
V
A
K
Y
C
C
E
H
--------
L
L
D
H
I
T
N
N
Q
D
F
K
GSAGAP
S
V
E
N
V
K
N
G
I
R
-
T
G
----
F
L
E
-
I
D
-
E
H
M
R
V
M
S
-
E
K
K
H
-
G
A
D
R
S
--
G
S
T
A
V
G
V
LISPQ
H
T
Y
F
--
I
N
C
-
G
D
S
R
G
L
L
C
R
NR
K
V
H
F
F
T
Q
D
H
K
P
S
N
P
L
E
K
E
R
I
---
Q
N
A
G
G
S
V
M
I
Q
R
V
N
G
---------------
S
L
A
V
S
R
A
L
G
D
F
D
--
Y
K
C
V
-
H
G
-----
K
-
G
P
T
E
Q
L
V
S
P
E
P
E
V
H
D
I
E
R
-----------
S
E
E
--
D
-
D
Q
F
I
I
L
-
A
C
----------------------------
D
G
I
W
D
-----
V
M
--------
G
N
E
E
L
-----
C
D
F
V
R
S
R
L
E
---
V
T
D
D
L
----------
E
---------------------------
K
-------
V
---
C
N
E
V
V
D
T
C
L
Y
K
GSR------------------------
D
N
M
S
V
I
L
I
C
F
PN------
A
P
K
V
S
P
E
A
V
K
K
E
-------
A
----
E
-------
L
---
D
K
Y
---------
L
E
C
R
V
E
E
I
I
KG
V
P
-
D
L
V
H
V
M
R
T
L
A
S
E
N
I
PSLPPGGE
L
A
S
K
R
N
-
V
I
------------------
E
A
V
Y
N
R
------
L
N
P
Y-----------
26
HHSearch
67.05
20%
-172
- C3 -
3EML
8
ENLYS_BPT4
A:
[21-219]
-------------------------------------------------------------------------------
S
S
V
Y
I
T
---------
V
E
L
A
-----------
I
A
V
L
A
I
-----
L
G
-
N
V
L
V
C
W
A
V
W
--------
L
N
S
N
L
Q
N
V
T
N
Y
F
------
V
V
S
L
A
A
A
D
I
A
-
V
G
----
V
L
A
-
I
P
-
F
A
I
T
I
S
T
---
G
F
-
C
A
A
C
H
--
G
C
L
F
--------
I
A
C
F
--
V
L
V
L
T
Q
S
S
I
F
S
L
---
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
---------------
V
L
S
F
A
I
G
L
T
P
M
L
--
G
W
N
N
-
C
G
-----
Q
--------
S
Q
G
C
G
E
G
Q
----------
V
A
C
L
F
E
D
VV
P
-
M
N
Y
M
V
Y
-
F
N
----------------------------
F
F
A
C
V
-----
L
V
P
L
L
-----
L
M
L
G
V
-----
Y
L
R
I
F
L
A
A
R
---
R
Q
L
N
I
----------
F
---------------------------
E
-------
M
---
L
R
I
D
E
G
L
R
L
-----------------------------
K
I
Y
K
D
T
E
G
Y
Y
--------
T
I
G
I
G
H
L
L
T
K
S
P
-------
S
----
L
-------
N
---
A
A
K
---------
S
E
L
D
K
A
I
G
R
--
N
T
-
N
G
V
I
T
K
D
E
A
E
K
L
F
N
--------
Q
D
V
D
A
A
-
V
R
------------------
G
I
L
R
N
A
------
K
L
K
------------
24
HHSearch
64.91
17%
-159
- C3 -
2RH1
6
ADRB2_HUMAN (first)
A:
[41-233]
--------------------------------------------------------------------------------
V
G
M
G
I
---------
V
M
S
L
-----------
I
V
L
A
I
V
-----
F
G
-
N
V
L
V
I
T
A
I
A
--------
K
F
E
R
L
Q
T
V
T
N
Y
F
------
I
T
S
L
A
C
A
D
L
V
-
M
G
----
L
A
V
-
V
P
-
F
G
A
A
H
I
L
-
M
K
M
W
-
T
F
G
N
F
--
W
C
E
F
--------
W
T
S
I
--
D
V
L
C
V
T
A
S
I
E
T
L
---
C
V
I
A
V
D
R
Y
F
A
I
T
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
---------------
I
V
S
G
L
T
S
F
L
P
I
Q
--
M
H
W
Y
-
R
A
-----
T
-
H
----
Q
E
A
I
N
C
Y
A
E
-----------
E
T
C
C
D
F
F
--
T
-
N
Q
A
Y
A
I
-
A
S
----------------------------
S
I
V
S
F
-----
Y
V
P
L
V
-----
I
M
V
F
V
-----
Y
S
R
V
F
Q
E
A
K
---
R
Q
L
N
I
----------
F
---------------------------
E
-------
M
---
L
R
I
D
E
G
L
R
L
-----------------------------
K
I
Y
K
D
T
E
G
Y
Y
--------
T
I
G
I
G
H
L
L
T
K
S
P
-------
S
----
L
-------
N
---
A
A
K
---------
S
E
L
D
K
A
I
G
R
--
N
T
-
N
G
V
I
T
K
D
E
A
E
K
L
F
N
--------
Q
D
V
D
A
A
-
V
R
------------------
G
I
L
R
N
A
------
K
L
K
------------
29
HHSearch
61.72
20%
-171
- C3 -
3PBL
1
DRD3_HUMAN (first)
A:
[41-224]
----------------------------------------------------------------------------------
Y
A
L
---------
S
Y
C
A
-----------
L
I
L
A
I
V
-----
F
G
-
N
G
L
V
C
M
A
V
L
--------
K
E
R
A
L
Q
T
T
T
N
Y
L
------
V
V
S
L
A
V
A
D
L
L
-
V
A
----
T
L
V
-
M
P
-
W
V
V
Y
L
E
V
T
G
G
V
W
-
N
F
S
R
I
--
C
C
D
V
--------
F
V
T
L
--
D
V
M
M
C
T
A
S
I
W
N
L
---
C
A
I
S
I
D
R
Y
T
A
V
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
---------------
V
L
A
F
A
V
S
C
P
L
L
F
--
G
F
N
T
-
T
-------------
G
D
P
T
V
C
S
I
-----------------
S
N
--
P
--
D
-
F
V
I
-
Y
S
----------------------------
S
V
V
S
F
-----
Y
L
P
F
G
-----
V
T
V
L
V
-----
Y
A
R
I
Y
V
V
L
K
---
Q
R
R
R
K
----------
N
---------------------------
I
-------
F
---
E
M
L
R
I
D
E
G
L
-----------------------------
R
L
K
I
Y
K
D
T
E
G
--------
Y
Y
T
I
G
I
G
H
L
L
T
K
-------
S
----
P
-------
S
---
L
N
A
---------
A
K
S
E
L
D
K
A
I
--
G
R
-
N
T
N
G
V
I
T
K
D
E
A
E
K
L
--------
F
N
Q
D
V
D
-
A
A
------------------
V
R
G
I
L
R
------
N
A
K
------------
49
Fugue
61.26
19%
-85
- C2 -
4OWT
-
INT3_HUMAN
A:
[1-466]
GGRL
L
L
S
T
SLDAKD
E
L
E
E
R
L
E
R
C
M
S
I
V
T
S
M
T
AGVS
E
R
E
A
N
D
A
L
N
A
Y
V
C
K
G
L
P
Q
H
----------------
E
------
E
I
C
L
G
L
F
T
---------
L
I
L
T
E
PAQ
A
Q
K
C
Y
R
D
L
A
L
V
S
R
-----
D
G
M
N
I
V
L
N
K
I
N
Q
I
L
M
EKYLK
L
Q
D
T
C
R
T
Q
L
V
W
L
------
V
R
E
L
V
K
S
G
V
L
G
A
D
----
G
V
C
M
T
F
M
K
Q
I
A
G
G
D
-
V
T
A
K
-
N
I
W
L
A
--
E
S
V
L
--------
D
I
L
T
E
Q
R
E
W
V
L
K
S
S
I
L
I
A
M
--
A
V
Y
T
Y
L
R
L
I
V
D
H
H
G
T
A
Q
L
Q
A
---
L
R
Q
K
E
V
D
F
C
I
S
L
L
R
E
R
F
M
E
C
L
MIG
R
D
L
V
R
L
L
Q
N
V
A
R
I
P
E
F
E
--
L
L
W
K
-
D
I
-----
I
-
H
N
P
Q
A
L
S
P
Q
F
T
G
I
L
Q
L
L
Q
S
R
T
S
R
K
F
L
A
C
R
L
T
P
--
D
M
E
T
K
L
L
F
M
T
S
RVRFGQQ
K
R
Y
Q
D
W
F
Q
R
Q
YLSTPDS
Q
S
L
R
C
D
L
I
R
-----
Y
I
C
G
V
V
H
P
S
N
E
V
L
S
S
DILP
R
W
A
I
I
G
W
L
L
T
---
T
C
T
S
N
----------
V
---------------------------
A
-------
A
---
S
N
A
K
L
A
L
F
Y
DWLFFSPDKDSIMNI
E
P
A
I
L
V
M
H
H
S
MKPH
P
A
I
T
A
T
L
L
D
F
M
-------
C
R
I
I
P
N
F
Y
P
P
L
E
-------
G
----
H
-------
V
---
R
Q
G
---------
V
F
S
S
L
N
H
I
V
--
E
K
R
V
L
A
H
L
A
P
L
F
D
N
P
K
L
--------
D
K
E
L
R
A
M
L
R
------------------
E
K
F
P
E
F
------
C
S
-------------