@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PTAFR_HUMAN: (2016-01-14 )
MEPHDSSHMDSEFRYTLFPIVYSIIFVLGVIANGYVLWVFARLYPCKKFNEIKIFMVNLTMADMLFLITLPLWIVYYQNQGNWILPKFLCNVAGCLFFINTYCSVAFLGVITYNRFQAVTRPIKTAQANTRKRGISLSLVIWVAIVGAASYFLILDSTNTVPDSAGSGNVTRCFEHYEKGSVPVLIIHIFIVFSFFLVFLIILFCNLVIIRTLLMQPVQQQRNAEVKRRALWMVCTVLAVFIICFVPHHVVQLPWTLAELGFQDSKFHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLTEKFYSMRSSRKCSRATTDTVTEVVVPFNQIPGNSLKN
Atome Classification :
(20 SA)
----------------------..----------.......10........20........30........--40........50........60........--70........80---.........90........100.......110.......120--........---.130.......140.--......150.......160...-....170.----....-----.--.180--.-..---.....190....--.....200...--....210----...----------------------------------------------..------------------------------------------...----------------------------------------220------------------------------------------------------------------------------------------------------------------------------------------------------------.--------------------------------------------------------------------------------------------------------------------------------------------------------------.....----...230.......240.......---250.......-260.--.--.---.---...270.......280.......290.......300.......310.......320.......330.......340
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------ME----------PHDSSHMDS
E
F
R
Y
T
L
F
P
I
V
Y
S
I
I
F
V
L
G
V
IAN
G
Y
V
L
W
V
--
F
A
R
LYPCKKF
N
E
I
K
I
F
M
V
NL
T
M
A
D
M
L
F
L
I
T
--
L
P
L
W
I
V
Y
Y
QNQ----G
N
W
I
L
P
K
F
L
C
N
V
A
G
C
L
F
F
I
N
T
Y
C
S
V
A
F
L
G
V
I
T
Y
N
R
F
Q
A
V
T----R
P
I
K
TAQA---NTRKRG
I
S
L
S
L
V
I
W
V
--
A
I
V
GA
A
S
Y
F
L
I
L
DSTNTVPDSA-GSG
N
V
T
R
C
----
F
E
H
Y
-----E--KGS---V-
P
V
---
L
I
I
H
I
F
--
I
V
F
S
--
F
F
L
V
F
L
I
I
L
F
C
--
N
L
V
I
I
R
-----
T
L
L
----------------------------------------------
M
Q
------------------------------------------
P
V
Q
----------------------------------------
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------
R
N
A
E
V
----
K
R
R
A
L
W
M
V
C
T
V
L
A
V
F
I
I
C
F
VP
H
H
---
V
V
QL
P
W
T
L
A
E-LGFQ--
D
--
S
---
K
---
F
H
Q
A
I
NDA
H
Q
V
T
L
C
L
LSTNC
V
L
D
P
V
I
Y
C
F
L
T
K
K
F
R
K
H
L
T
E
K
F
Y
S
M
R
SSRKCSRATTDT
V
T
E
V
V
V
P
F
NQIPGNSLKN
42
Fugue
82.70
27%
-164
- C3 -
4XNV
15
P2RY1_HUMAN (first)
A:
[38-382]
----------------------------------
S
F
K
C
A
L
T
K
T
G
F
Q
F
Y
Y
L
P
A
V
Y
I
L
V
F
I
I
G
F
L
G
N
S
V
A
I
W
M
--
F
V
F
H
M
--
K
P
W
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
L
T
--
L
P
A
L
I
F
Y
Y
F
N
K
----
T
D
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
----
Y
P
-
K
S
L
G
R
---
L
K
K
K
N
A
I
C
I
S
V
L
V
W
L
--
I
V
V
V
A
I
S
P
I
L
F
Y
S
G
T
G
V
R
K
N
------
K
T
I
T
C
----
Y
D
T
T
-----
S
--
D
E
Y
---
L
-
R
S
---
Y
F
I
Y
S
M
--
C
T
T
V
A
M
F
C
V
P
L
V
L
I
L
G
C
--
Y
G
L
I
V
R
-----
A
L
I
Y
K
--------------------------------------------
M
K
------------------------------------------
K
Y
T
C
TVCG
Y
I
Y
N
PEDGDPDNGVNPGTDFKDIVCPLCGVGKDQ
F
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
E
P
L
----
R
R
K
S
I
Y
L
V
I
I
V
L
T
V
F
A
V
S
Y
I
P
F
H
---
V
M
K
T
M
N
L
R
A
R
-
L
D
F
Q
--
T
--
P
---
A
M
C
A
F
N
D
R
V
Y
A
T
Y
Q
V
T
R
G
L
A
S
L
N
S
C
V
N
P
I
L
Y
F
L
A
G
D
T
F
R
R
R
---------------------------------------
9
PsiBlast_PDB
80.57
21%
-174
- C3 -
4MBS
8
CCR5_HUMAN (first)
A:
[34-366]
------------------------------------------------
L
L
P
P
L
Y
S
L
V
F
I
F
G
F
V
G
N
M
L
V
I
L
I
--
L
I
N
Y
K
R
L
K
S
M
T
D
I
--
Y
L
L
N
L
A
I
S
D
L
F
F
L
L
T
--
V
P
F
W
A
H
Y
A
A
A
Q
------
W
D
F
G
N
T
M
C
Q
L
L
T
G
L
Y
F
I
G
F
F
S
G
I
F
F
I
I
L
L
T
I
D
R
Y
L
A
V
V
----
H
A
V
F
A
L
K
A
---
R
T
V
T
F
G
V
V
T
S
V
I
T
W
V
--
V
A
V
F
A
S
L
P
N
I
I
F
T
R
------
S
Q
-
K
E
G
L
H
Y
T
C
----
S
S
H
F
-----
P
--
Y
S
Q
---
Y
-
Q
F
W
K
N
F
Q
T
L
K
I
--
V
I
L
G
--
L
V
L
P
L
L
V
M
V
I
C
--
Y
S
G
I
L
K
-----
T
L
L
R
M
K
K
Y
T
C
TVCG
Y
I
Y
N
PEDGDPDNGVNPGTDFKDIPDDWVCPLCGVG
K
D
------------------------------------------
Q
F
E
----------------------------------------
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
E
K
K
----
R
H
R
D
V
R
L
I
F
T
I
M
I
V
Y
F
L
F
W
A
P
Y
N
---
I
V
L
L
L
N
T
F
Q
E
F
F
G
L
N
--
N
--
C
---
S
---
S
S
N
R
L
D
Q
A
M
Q
V
T
E
T
L
G
M
T
H
C
C
I
N
P
I
I
Y
A
F
V
G
E
E
F
R
N
Y
L
L
V
F
F
Q
---------------------------------
1
PsiBlast_PDB
80.51
24%
-177
- C3 -
4XNV
15
P2RY1_HUMAN (first)
A:
[46-382]
------------------------------------------
T
G
F
Q
F
Y
Y
L
P
A
V
Y
I
L
V
F
I
I
G
F
L
G
N
S
V
A
I
W
M
--
F
--
V
F
H
M
K
P
W
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
L
T
--
L
P
A
L
I
F
Y
Y
F
N
K
----
T
D
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
----
Y
P
-
K
S
L
G
R
---
L
K
K
K
N
A
I
C
I
S
V
L
V
W
L
--
I
V
V
V
A
I
S
P
I
L
F
Y
S
G
T
G
V
R
K
N
------
K
T
I
T
C
----
Y
D
T
T
-----
S
--
D
E
Y
---
L
-
R
S
---
Y
F
I
Y
S
M
C
T
T
V
A
M
--
F
C
V
P
L
V
L
I
L
G
C
--
Y
G
L
I
V
R
-----
A
L
I
----------------------------------------------
Y
K
M
K
K
Y
T
C
TVCG
Y
I
Y
N
PEDGDPDNGVNPGTDFKDIVCPLC----
G
V
G
----------------------------------------
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
E
E
V
EE
P
L
R
R
K
S
I
Y
L
V
I
I
V
L
T
V
F
A
V
S
Y
I
P
F
H
---
V
M
K
T
M
N
L
R
A
R
-
L
D
F
Q
--
T
--
P
AM
C
A
---
F
N
D
R
V
Y
A
T
Y
Q
V
T
R
G
L
A
S
L
N
S
C
V
N
P
I
L
Y
F
L
A
G
D
T
F
R
R
R
---------------------------------------
2
PsiBlast_PDB
79.72
24%
-173
- C3 -
4XNW
2
RUBR_CLOPA
A:
[46-382]
------------------------------------------
T
G
F
Q
F
Y
Y
L
P
A
V
Y
I
L
V
F
I
I
G
F
L
G
N
S
V
A
I
W
M
--
F
--
V
F
H
M
K
P
W
S
G
I
S
V
Y
M
F
N
L
A
L
A
D
F
L
Y
V
L
T
--
L
P
A
L
I
F
Y
Y
F
N
K
----
T
D
W
I
F
G
D
A
M
C
K
L
Q
R
F
I
F
H
V
N
L
Y
G
S
I
L
F
L
T
C
I
S
A
H
R
Y
S
G
V
V
----
Y
P
L
K
S
L
G
R
---
L
K
K
K
N
A
I
C
I
S
V
L
V
W
L
--
I
V
V
V
A
I
S
P
I
L
F
Y
S
G
T
G
V
R
K
N
------
K
T
I
T
C
----
Y
D
T
T
-----
S
--
D
E
Y
---
L
-
R
S
---
Y
F
I
Y
S
M
C
T
T
V
A
M
--
F
C
V
P
L
V
L
I
L
G
C
--
Y
G
L
I
V
R
-----
A
L
I
----------------------------------------------
Y
K
M
K
K
Y
T
C
TVCG
Y
I
Y
N
PEDGDPDNGVNPGTDFKDIPDDWVCPLC
G
V
G
----------------------------------------
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
E
E
V
EE
P
L
R
R
K
S
I
Y
L
V
I
I
V
L
T
V
F
A
V
S
Y
I
P
F
H
---
V
M
K
T
M
N
L
R
A
R
-
L
D
F
Q
--
T
--
P
AM
C
A
---
F
N
D
R
V
Y
A
T
Y
Q
V
T
R
G
L
A
S
L
N
S
C
V
N
P
I
L
Y
F
L
A
G
D
T
F
R
R
R
---------------------------------------
15
PsiBlast_PDB
79.26
25%
-165
- C3 -
4RWA
2
C562_ECOLX (first)
A:
[128-400]
----------------------------------------------------
L
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
M
F
G
--
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
--
N
L
A
L
A
D
A
L
A
T
S
T
--
L
P
F
Q
S
A
K
Y
L
M
E
-----
T
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
----
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
--
L
A
S
G
V
G
V
P
I
M
V
M
A
V
T
R
P
------
R
D
G
A
V
V
-
C
----
M
L
Q
F
-----
P
--
S
P
S
W
Y
W
D
-
T
V
---
T
K
I
C
V
F
--
L
-
F
A
--
F
V
V
P
I
L
I
I
T
V
C
Y
G
L
M
L
L
------------------------------------------------------------------------------------------------------
G
----------------------------------------
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
D
R
S
----
L
R
R
I
T
R
M
V
L
V
V
V
G
A
F
V
V
C
W
A
P
I
H
---
I
F
V
I
V
W
T
L
V
D
-
I
D
R
R
--
D
--
P
---
L
---
V
V
A
A
L
H
----
L
C
I
A
L
G
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
Q
L
C
----------------------------------
16
PsiBlast_PDB
76.02
25%
-162
- C3 -
4RWD
6
C562_ECOLX (first)
A:
[128-400]
----------------------------------------------------
L
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
M
F
G
--
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
--
N
L
A
L
A
D
A
L
A
T
S
T
--
L
P
F
Q
S
A
K
Y
L
M
E
-----
T
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
----
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
--
L
A
S
G
V
G
V
P
I
M
V
M
A
V
T
R
P
------
R
D
G
A
V
V
-
C
----
M
L
Q
F
-----
P
--
S
P
S
W
Y
W
D
-
T
V
---
T
K
I
C
V
F
--
L
-
F
A
--
F
V
V
P
I
L
I
I
T
V
C
Y
G
L
M
L
L
R
L
-----
R
S
V
----------------------------------------------
R
L
------------------------------------------
L
S
G
----------------------------------------
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
D
R
S
----
L
R
R
I
T
R
M
V
L
V
V
V
G
A
F
V
V
C
W
A
P
I
H
---
I
F
V
I
V
W
T
L
V
D
-
I
D
R
R
--
D
--
P
---
L
---
V
V
A
A
L
H
----
L
C
I
A
L
G
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
Q
L
C
----------------------------------
20
PsiBlast_PDB
75.11
27%
-162
- C3 -
4EA3
3
C562_ECOLX (first)
A:
[131-401]
----------------------------------------------------
L
Y
L
A
V
C
V
G
G
L
L
G
N
C
L
V
M
Y
V
--
I
L
R
H
T
K
M
K
T
A
T
N
I
Y
I
F
--
N
L
A
L
A
D
T
L
V
L
L
T
--
L
P
-----
F
Q
G
T
D
I
L
L
G
F
W
P
F
G
N
A
L
C
K
T
V
I
A
I
D
Y
Y
N
M
F
T
S
T
F
T
L
T
A
M
S
V
D
R
Y
V
A
I
C
----
H
P
----------
T
S
S
K
A
Q
A
V
N
V
A
I
W
---
A
L
A
S
V
V
G
V
P
V
A
I
M
G
S
A
Q
V
E
D
E
E
------
I
E
C
----
L
V
E
I
-----
P
--
T
P
Q
DY
W
G
-
P
V
---
F
A
I
C
I
F
--
L
-
F
S
--
F
I
V
P
V
L
V
I
S
V
C
--
Y
S
L
M
I
R
R
L
RGV
R
L
L
----------------------------------------------
S
G
------------------------------------------
S
R
E
----------------------------------------
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------
R
N
L
-------
R
R
I
T
R
L
V
L
V
V
V
A
V
F
V
G
C
W
T
P
V
Q
---
V
----
F
V
L
A
Q
G
L
G
V
Q
--
P
--
S
---
S
----
E
T
A
V
A
I
L
R
F
C
T
-
A
L
G
Y
V
N
S
C
L
N
P
I
L
Y
A
F
L
D
E
N
F
K
A
C
F
R
-------------------------------------
14
PsiBlast_PDB
73.91
25%
-161
- C3 -
4N6H
22
OPRD_HUMAN
A:
[131-403]
----------------------------------------------------
L
Y
S
A
V
C
A
V
G
L
L
G
N
V
L
V
M
F
G
--
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
--
N
L
A
L
A
D
A
L
A
T
S
T
--
L
P
F
Q
S
A
K
Y
L
M
E
-----
T
W
P
F
G
E
L
L
C
K
A
V
L
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
T
M
M
S
V
D
R
Y
I
A
V
C
----
H
P
V
K
A
L
D
F
---
R
T
P
A
K
A
K
L
I
N
I
C
I
W
V
--
L
A
S
G
V
G
V
P
I
M
V
M
A
V
T
R
P
------
R
D
G
A
V
V
-
C
----
M
L
Q
F
-----
P
--
S
P
S
W
Y
W
D
-
T
V
---
T
K
I
C
V
F
--
L
-
F
A
--
F
V
V
P
I
L
I
I
T
V
C
Y
G
L
M
L
L
R
L
-----
R
S
V
----------------------------------------------
R
L
------------------------------------------
L
S
G
----------------------------------------
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
D
R
S
----
L
R
R
I
T
R
M
V
L
V
V
V
G
A
F
V
V
C
W
A
P
I
H
---
I
F
V
I
V
W
T
L
V
D
-
I
D
R
R
--
D
--
P
---
L
---
V
V
A
A
L
H
----
L
C
I
A
L
G
Y
A
N
S
S
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
R
Q
L
C
R
K
P
C
G
-----------------------------
25
HHSearch
73.81
24%
-160
- C3 -
3ODU
6
CXCR4_HUMAN (first)
A:
[46-497]
--------------------------------------------
F
N
K
I
F
L
P
T
I
Y
S
I
I
F
L
T
G
I
V
G
N
G
L
V
I
L
V
--
M
G
Y
Q
--
K
K
L
R
S
M
T
D
K
Y
R
L
H
L
S
V
A
D
L
L
F
V
I
T
--
L
P
F
W
A
V
D
A
V
------
A
N
W
Y
F
G
N
F
L
C
K
A
V
H
V
I
Y
T
V
N
L
Y
S
S
V
W
I
L
A
F
I
S
L
D
R
Y
L
A
I
V
----
H
A
T
N
S
Q
R
P
---
R
K
L
L
A
E
K
V
V
Y
V
G
V
W
I
--
P
A
L
L
L
T
I
P
D
F
I
F
A
N
V
S
E
-------
A
D
D
R
Y
I
C
----
D
R
F
Y
-----
P
--
N
D
L
---
W
-
V
V
---
V
F
Q
F
Q
H
--
I
M
V
G
--
L
I
L
P
G
I
V
I
L
S
C
--
Y
C
I
I
I
S
-----
K
L
S
----------------------------------------------
H
S
------------------------------------------
G
S
N
----------------------------------------
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
IGRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKLK
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KRW
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAY
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
G
H
Q
----
K
R
K
A
L
K
T
T
V
I
L
I
L
A
F
F
A
C
W
L
P
Y
Y
---
I
G
I
S
I
D
S
F
I
L
-
L
E
I
I
K
Q
G
--
C
---
E
---
F
E
N
T
V
H
K
W
I
S
I
T
E
A
L
A
F
F
H
C
C
L
N
P
I
L
Y
A
F
L
G
A
K
F
K
T
S
A
Q
H
A
L
T
S
G
R
P
L
E
V
L
F
Q
-----------------------
44
Fugue
72.19
15%
-128
- C3 -
1F88
8
OPSD_BOVIN
A:
[1-348]
MN
G
T
E
G
PNFYVPFSNKTGVVRS
P
F
----------
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
--
T
V
Q
H
K
K
L
R
--
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
--
G
F
T
T
T
L
Y
T
S
L
H
----
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
----
K
P
M
S
N
F
R
F
---
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
--
A
L
A
C
A
A
P
P
L
V
--
G
W
S
R
Y
I
P
E
G
M
-
Q
C
S
C
G
I
D
Y
----
Y
T
P
H
-----
E
--
E
T
N
---
N
-
E
S
---
F
V
I
Y
M
F
--
V
V
H
---
F
I
I
P
L
I
V
I
F
F
C
--
Y
G
Q
L
V
F
-----
T
V
-----------------------------------------------
K
E
------------------------------------------
A
A
A
----------------------------------------
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
Q
K
A
----
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
----
A
G
V
A
F
Y
I
F
T
H
-
Q
G
S
D
--
F
--
G
------------
P
I
F
M
T
I
P
A
F
F
A
K
T
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
S
T
T
V
S
K
T
E
T
S
Q
V
A
--------
P
A
-----
8
PsiBlast_PDB
72.01
30%
-159
- C3 -
5C1M
7
?
A:
[23-294]
----------------------------------------------------
L
Y
S
I
V
C
V
V
G
L
F
G
N
F
L
V
M
Y
V
--
I
V
R
Y
T
K
M
K
T
A
T
N
I
Y
I
F
--
N
L
A
L
A
D
A
L
A
T
S
T
--
L
P
F
Q
S
V
N
Y
L
-
M
----
G
T
W
P
F
G
N
I
L
C
K
I
V
I
S
I
D
Y
Y
N
M
F
T
S
I
F
T
L
C
T
M
S
V
D
R
Y
I
A
V
C
----
H
P
V
K
A
L
D
F
---
R
T
P
R
N
A
K
I
V
N
V
C
N
W
I
L
S
S
A
I
G
L
P
V
M
F
M
-----
A
T
T
K
Y
R
Q
-
G
S
I
D
C
T
L
T
----
F
S
H
P
-----
T
--
W
Y
W
---
E
-
N
L
---
L
K
I
C
V
F
--
I
-
F
A
--
F
I
M
P
V
L
I
I
T
V
C
Y
-
G
L
M
I
L
R
L
K
S
V-
R
M
L
----------------------------------------------
S
G
------------------------------------------
S
K
E
----------------------------------------
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------
R
N
L
-------
R
R
I
T
R
M
V
L
V
V
V
A
V
F
I
V
C
W
T
P
I
H
I
Y
V
I
I
K
A
L
I
T
I
P
E
-
T
T
F
Q
--
T
--
V
---
S
---
W
H
F
C
I
A
L
G
Y
--------
T
N
S
C
L
N
P
V
L
Y
A
F
L
D
E
N
F
K
R
C
F
--------------------------------------
31
HHSearch
71.78
22%
-160
- C3 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
-------------------------------------------------
Y
A
L
S
Y
C
A
L
I
L
A
I
V
F
G
N
G
L
V
C
M
A
--
V
L
K
E
--
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
T
L
V-
M
P
W
V
V
Y
L
E
V
T
G
----
G
V
W
N
F
S
R
I
C
C
D
V
F
V
T
L
D
V
M
M
C
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
V
----
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
--
L
A
F
A
V
S
C
P
L
L
F
G
F
N
T
T
---------
G
D
P
T
V
C
----
S
I
S
N
-----
P
-----------
D
---
F
V
I
-
Y
S
--
S
V
V
S
--
F
Y
L
P
F
G
V
T
V
L
V
--
Y
A
R
I
Y
V
-----
V
L
K
----------------------------------------------
Q
R
------------------------------------------
R
R
K
----------------------------------------
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWDAY
G
V
P
L
R
----
E
K
K
A
T
Q
M
V
A
I
V
L
G
A
F
I
V
C
W
L
P
F
F
---
L
T
H
V
L
N
T
H
C
Q
-
T
--------
C
---
H
------
V
S
P
E
L
Y
S
A
T
T
W
L
G
Y
V
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
S
C
--------------------------------
35
HHSearch
71.10
21%
-141
* C3 *
2Z73
5
OPSD_TODPA
A:
[34-335]
----------------------------------------------
Y
Y
S
L
G
I
F
I
G
I
C
G
I
I
G
C
G
G
N
G
I
V
I
Y
L
--
F
T
K
T
--
K
S
L
Q
T
P
A
N
M
F
I
I
N
L
A
F
S
D
F
T
F
S
L
V
N
G
F
P
L
M
T
I
-
S
C
F
L
----
K
K
W
I
F
G
F
A
A
C
K
V
Y
G
F
I
G
G
I
F
G
F
M
S
I
M
T
M
A
M
I
S
I
D
R
Y
N
V
I
G
----
R
P
M
A
A
S
K
K
---
M
S
H
R
R
A
F
I
M
I
I
F
V
W
L
--
W
S
V
L
W
A
I
G
P
I
F
G
W
G
A
Y
T
L
------
E
G
V
L
C
N
C
----
S
F
D
Y
-----
I
--
S
R
D
---
S
T
T
R
---
S
N
I
L
C
M
--
F
I
L
G
--
F
F
G
P
I
L
I
I
F
F
C
--
Y
F
N
I
V
M
-----
S
V
S
----------------------------------------------
N
H
------------------------------------------
E
K
E
----------------------------------------
M
A
A
M
A
K
RLNAKE
L
R
K
A
-----------------------------------------------------------------------------------------------------------------------------------------------
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
A
N
A
----
E
M
R
L
A
K
I
S
I
V
I
V
S
Q
F
L
L
S
W
S
P
Y
A
---
V
V
A
L
L
A
Q
F
G
P
-
L
--------
E
---------
W
V
T
P
Y
A
A
Q
L
P
V
M
F
A
K
A
S
A
I
H
N
P
M
I
Y
S
V
S
H
P
K
F
R
E
A
I
S
Q
T
F
P
W
V
L
T
C
C
Q
F
D
D
K
E
T
E
D
D
K
D
A
E
T
E
I
P
A
G
E
------
28
HHSearch
70.77
19%
-151
- C3 -
3EML
13
ENLYS_BPT4
A:
[23-472]
------------------------------------------------
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
--
V
W
L
N
--
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
V
L
A
-
I
P
F
A
I
T
I
S
-------
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
----
I
P
L
R
Y
N
G
L
---
V
T
G
T
R
A
K
G
I
I
A
I
C
W
V
--
L
S
F
A
I
G
L
T
P
M
L
G
W
N
N
C
G
Q
---------
S
Q
G
C
----
G
E
G
Q
VACLF
E
--
D
V
V
---
P
-
M
N
---
Y
M
V
Y
F
N
--
F
F
A
C
--
V
L
V
P
L
L
L
M
L
G
V
--
Y
L
R
I
F
L
-----
A
A
R
----------------------------------------------
R
Q
------------------------------------------
L
N
I
----------------------------------------
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
-
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------
S
T
L
Q
K
----
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
---
I
I
N
C
F
T
F
F
C
P
-------
D
--
C
---
S
-----
H
A
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
---------------------------
43
Fugue
69.16
17%
-115
- C3 -
1U19
15
OPSD_BOVIN
A:
[4-349]
----------MN
G
T
E
G
PNFYVP
F
S
NKTGVVRSPF
E
A
P
Q
Y
Y
L
A
E
P
W
Q
F
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
--
T
V
Q
H
K
K
L
R
--
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
F
G
--
G
F
T
T
T
L
Y
T
S
L
H
----
G
Y
F
V
F
G
P
T
G
C
N
L
E
G
F
F
A
T
L
G
G
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
C
----
K
P
M
S
N
F
R
F
---
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
--
A
L
A
C
A
A
P
P
L
V
--
G
W
S
R
Y
I
P
E
-----
G
M
Q
C
S
C
G
I
DY
Y
T
P
H
-----
E
--
E
T
N
---
N
-
E
S
---
F
V
I
Y
M
F
--
V
V
H
---
F
I
I
P
L
I
V
I
F
F
C
--
Y
G
Q
L
V
F
-----
T
V
K
----------------------------------------------
E
A
------------------------------------------
A
A
Q
----------------------------------------
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
ESA-----------------------------------------------------------------------------------------------------------------------------------------------------------
T
T
Q
K
A
----
E
K
E
V
T
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
Y
----
A
G
V
A
F
Y
I
F
T
H
-
Q
G
S
D
--
F
--
G
---
P
---
I
F
M
T
I
P
A
F
F
A
K
T
S
A
------
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
G
K
N
P
L
G
D
D
E
A
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
-------
6
PsiBlast_PDB
68.39
26%
-189
- C3 -
4XT1
14
US28_HCMVA
A:
[44-310]
-----------------------------------------------
T
L
F
--
L
Y
G
V
V
F
L
F
G
S
I
G
N
F
L
V
I
F
T
I
T
W
R
R
R
I
Q
C
S
G
----
D
V
Y
F
I
N
L
A
A
A
D
L
L
F
V
C
T
--
L
P
L
W
M
Q
Y
L
L
D
-----------
S
V
P
C
T
L
L
T
A
C
F
Y
V
A
M
F
A
S
L
C
F
I
T
E
I
A
L
D
R
Y
Y
A
I
V
YM
R
Y
R
P
V
K
Q
A
-----------
C
L
F
S
I
F
W
W
I
F
-
A
V
I
I
A
I
P
H
F
M
V
V
T
K
K
D
------------
N
Q
C
----
M
T
D
Y
-----
D
YL
E
V
S
---
Y
-
P
I
---
I
L
N
V
E
L
--
M
L
G
A
--
F
V
I
P
L
S
V
I
S
Y
C
--
Y
Y
R
I
S
R
-----
I
V
-------------------------------------------------------------------------------------------
A
V
S
----------------------------------------
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------
R
H
-------
K
G
R
I
V
R
V
L
I
A
V
V
L
V
F
I
I
F
W
L
P
Y
H
---
L
T
L
F
V
D
T
L
K
L
-
L
K
W
I
--
S
--
S
S
C
-
E
---
F
E
R
S
L
K
R
A
L
I
L
T
E
S
L
A
F
C
H
C
C
L
N
P
L
L
Y
V
F
V
G
T
K
F
R
Q
E
L
H
C
L
L
A
E
F
R
------------------------------
7
PsiBlast_PDB
67.93
26%
-179
- C3 -
4XT3
2
US28_HCMVA
A:
[44-310]
-----------------------------------------------
T
L
F
--
L
Y
G
V
V
F
L
F
G
S
I
G
N
F
L
V
I
F
T
I
T
W
R
R
R
I
Q
C
S
G
----
D
V
Y
F
I
N
L
A
A
A
D
L
L
F
V
C
T
--
L
P
L
W
M
Q
Y
L
L
D
H
---------
A
S
V
P
C
T
L
L
T
A
C
F
Y
V
A
M
F
A
S
L
C
F
I
T
E
I
A
L
D
R
Y
Y
A
I
V
YM
R
Y
R
P
V
K
Q
A
-----------
C
L
F
S
I
F
W
W
I
F
-
A
V
I
I
A
I
P
H
F
M
V
V
T
K
K
D
------------
N
Q
C
----
M
T
D
Y
-----
D
YL
E
V
S
---
Y
-
P
I
---
I
L
N
V
E
L
--
M
L
G
A
--
F
V
I
P
L
S
V
I
S
Y
C
--
Y
Y
R
I
S
R
-----
I
V
-------------------------------------------------------------------------------------------
A
V
S
----------------------------------------
Q
--------------------------------------------------------------------------------------------------------------------------------------------------------------
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------
R
H
-------
K
G
R
I
V
R
V
L
I
A
V
V
L
V
F
I
I
F
W
L
P
Y
H
---
L
T
L
F
V
D
T
L
K
L
-
L
K
W
I
--
S
--
S
S
C
-
E
---
F
E
R
S
L
K
R
A
L
I
L
T
E
S
L
A
F
C
H
C
C
L
N
P
L
L
Y
V
F
V
G
T
K
F
R
Q
E
L
H
C
L
L
A
E
--------------------------------
32
HHSearch
67.90
24%
-148
- C3 -
2LNL
-
CXCR1_HUMAN
A:
[38-322]
---------------------------------------------
N
K
Y
V
V
I
I
A
Y
A
L
V
F
L
L
S
L
L
G
N
S
L
V
M
L
V
--
I
L
Y
S
--
R
V
G
R
S
V
T
D
V
Y
L
L
N
L
A
L
A
D
L
L
F
A
L
T
--
L
P
I
W
A
A
S
K
--
V
----
N
G
W
I
F
G
T
F
L
C
K
V
V
S
L
L
K
E
V
N
F
Y
S
G
I
L
L
L
A
C
I
S
V
D
R
Y
L
A
I
V
----
H
A
T
R
T
L
T
Q
----
K
R
H
L
V
K
F
V
C
L
G
C
W
G
--
L
S
M
N
L
S
L
P
F
F
L
F
R
Q
A
Y
-
H
P
-----
N
N
S
S
P
V
C
----
Y
E
V
L
-----
G
--
N
D
T
---
A
-
K
W
RM-
V
L
R
I
L
P
--
H
T
F
G
--
F
I
V
P
L
F
V
M
L
F
C
--
Y
G
F
T
L
R
-----
T
L
F
----------------------------------------------
K
A
------------------------------------------
H
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
G
Q
----
K
H
R
A
M
R
V
I
F
A
V
V
L
I
F
L
L
C
W
L
P
Y
N
---
L
V
L
L
A
D
T
L
M
R
-
T
Q
V
I
--
Q
E
S
C
---
E
---
R
R
N
N
I
G
R
A
L
D
A
T
E
I
L
G
F
L
H
S
C
L
N
P
I
I
Y
A
F
I
G
Q
N
F
R
H
G
F
L
K
I
L
A
M
H
G
------------------------------
27
HHSearch
67.85
18%
-159
- C3 -
3RZE
5
ENLYS_BPT4 (first)
A:
[12-443]
--------------------------------------------------
V
V
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
A
--
V
R
S
E
--
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
A
V
V
-
M
P
M
N
I
L
Y
L
-
L
M
----
S
K
W
S
L
G
R
P
L
C
L
F
W
L
S
M
D
Y
V
A
S
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
Q
----
Q
P
L
R
Y
L
K
Y
---
R
T
K
T
R
A
S
A
T
I
L
G
A
W
F
--
L
S
F
L
W
V
I
P
I
L
G
W
N
H
-----------
R
R
E
D
K
C
----
E
T
D
F
-----
Y
--
D
V
T
------
W
---
F
-
K
V
M
T
--
A
I
I
N
--
F
Y
L
P
T
L
L
M
L
W
F
--
Y
A
K
I
Y
K
-----
A
V
R
----------------------------------------------
Q
H
------------------------------------------
C
N
I
----------------------------------------
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDA--
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------
L
H
M
N
R
----
E
R
K
A
A
K
Q
L
G
F
I
M
A
A
F
I
L
C
W
I
P
Y
F
---
I
F
F
M
V
I
A
F
C
K
-
N
--------
C
----------
C
N
E
H
L
H
M
F
T
I
W
L
G
Y
I
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
L
H
I
--------------------------------
26
HHSearch
67.31
18%
-154
- C3 -
2RH1
16
ADRB2_HUMAN (first)
A:
[38-477]
--------------------------------------------
V
W
V
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
--
I
A
K
F
--
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
L
A
V-
V
P
F
G
A
A
H
I
-
L
M
----
K
M
W
T
F
G
N
F
W
C
E
F
W
T
S
I
D
V
L
C
V
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
T
----
S
P
F
K
Y
Q
S
L
---
L
T
K
N
K
A
R
V
I
I
L
M
V
W
I
--
V
S
G
L
T
S
F
L
P
I
Q
M
H
W
Y
R
A
T
H
Q
E
A
I
N
C
Y
A
E
E
T
C
----
C
D
F
F
-----
T
----
N
-----
Q
A
---
Y
A
-
I
A
S
--
S
I
V
S
--
F
Y
V
P
L
V
I
M
V
F
V
--
Y
S
R
V
F
Q
-----
E
A
K
----------------------------------------------
R
Q
------------------------------------------
L
N
I
----------------------------------------
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDA--
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------
K
F
C
L
K
----
E
H
K
A
L
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
---
I
V
N
I
V
H
V
I
Q
D
----------
N
---
L
------
I
R
K
E
V
Y
I
L
L
N
W
I
G
Y
V
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
--------------------------------