@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : S1PR3_HUMAN: (2016-01-14 )
MATALPPRLQPVRGNETLREHYQYVGKLAGRLKEASEGSTLTTVLFLVICSFIVLENLMVLIAIWKNNKFHNRMYFFIGNLALCDLLAGIAYKVNILMSGKKTFSLSPTVWFLREGSMFVALGASTCSLLAIAIERHLTMIKMRPYDANKRHRVFLLIGMCWLIAFTLGALPILGWNCLHNLPDCSTILPLYSKKYIAFCISIFTAILVTIVILYARIYFLVKSSSRKVANHNNSERSMALLRTVVIVVSVFIACWSPLFILFLIDVACRVQACPILFKAQWFIVLAVLNSAMNPVIYTLASKEMRRAFFRLVCNCLVRGRGARASPIQPALDPSRSKSSSSNNSSHSPKVKEDLPHTAPSSCIMDKNAALQNGIFCN
Atome Classification :
(20 SA)
.........10......--..20........30........-40........50........60........70........80........---90.........-100.........110..--.....120-----.------.......130.......140.......-.---150.......160.......170..--..--------.--------------..180---..------..---.--...-------.190..----...-.-.200.......210..---.....220.......230-----------------------------------------------------------------------------------------------------------------------------------------------------------..-......240----.-------.......250.......260.......270.......280........----290.......300.......310.......320.........330.......340.......350.......360.......370......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MATALPPRLQPVRG
N
E
T
--
L
R
E
H
Y
Q
Y
V
G
K
L
A
G
R
L
K
EASEG
S
-
T
L
T
T
V
L
F
L
V
I
C
S
F
I
V
L
E
N
L
M
V
L
I
A
I
WKNNKFH
N
R
M
Y
F
F
I
G
N
L
A
L
C
D
L
L
A
G
---
I
-
A
Y
K
V
N
I
L
MS-G--K
K
T
F
SLS
P
T
V
W
F
L
R--EG
S
M
F
V
A
------L------GA
S
T
C
S
L
L
A
I
A
I
E
R
H
L
T
M
-
I
K
MRPYDA-N---K
R
H
R
V
F
L
L
I
G
M
C
W
L
I
A
F
T
L
GA
L
P
I
L
--
G
W
--------
N
--------------
C
LH-----NL------P
D
---
C
--
S
T
I
-------
L
P
L
Y
S
K
----
K
Y
I
-
A
-
F
C
I
S
I
F
T
A
I
L
V
T
I
V
I
L
---
Y
A
R
I
Y
F
L
V
KSSSRKVAN------------------------------------------------------------------------------------------------------------------------------------------------------------HN-N
S
E
R
S
M
A
L
-----
L
-------
R
T
V
V
I
V
V
S
V
F
I
A
C
W
S
P
L
F
I
L
F
L
I
D
V
A
C
RVQA
C
P
I
L
F
K
A
Q
-
W
F
I
V
L
A
V
L
----
N
SAM
N
P
V
I
Y
TL
A
S
K
E
M
R
R
A
F
F
R
L
V
C
N
C
L
VRG--RGARASPIQPALDPSRSKSSSSNNSSHSPK
V
K
EDLPHTAP
S
S
CIMDKN
A
A
LQNGIFCN
27
HHSearch
93.37
57%
-193
- C1 -
3V2Y
1
ENLYS_BPT4
A:
[59-495]
------------------------------------
K
E
N
S
I
-
K
L
T
S
V
V
F
I
L
I
C
C
F
I
I
L
E
N
I
F
V
L
L
T
I
W
K
T
K
K
F
H
R
P
M
Y
Y
F
I
G
N
L
A
L
S
D
L
L
A
G
---
V
-
A
Y
T
A
N
L
L
L
S
-
G
--
A
T
T
Y
K
L
T
P
A
Q
W
F
L
R
--
E
G
S
M
F
V
A
------
L
------
S
A
S
V
F
S
L
L
A
I
A
I
E
R
Y
I
T
M
-
L
K
-----------
N
N
F
R
L
F
L
L
I
S
A
C
W
V
I
S
L
I
L
G
G
L
P
I
M
--
G
W
--------
N
--------------
C
I
S
-----
A
L
------
S
S
---
C
--
S
T
V
-------
L
P
L
Y
H
K
----
H
Y
I
-
L
-
F
C
T
T
V
F
T
L
L
L
L
S
I
V
I
L
---
Y
C
R
I
Y
S
L
V
R
T
R
N
I
F
E
M
L
R
IDEGLRL
K
I
Y
K
D
TE
G
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDAY--
A
S
-
R
S
S
E
N
V
A
L
-----
L
-------
K
T
V
I
I
V
L
S
V
F
I
A
C
W
A
P
L
F
I
L
L
L
L
D
V
G
C
K
V
K
T
C
D
I
L
F
R
A
E
-
Y
F
L
V
L
A
V
L
----
N
S
G
T
N
P
I
I
Y
T
L
T
N
K
E
M
R
R
A
F
I
R
I
M
G
R
P
L
---------------------------------------------------------------
1
PsiBlast_PDB
78.32
42%
-173
- C1 -
3V2W
2
ENLYS_BPT4 (first)
A:
[41-343]
---------------
D
I
--
I
V
R
H
Y
N
Y
T
G
K
L
--
N
I
S
A
-------
L
T
S
V
V
F
I
L
I
C
C
F
I
I
L
E
N
I
F
V
L
L
T
I
W
K
T
K
K
F
H
R
P
M
Y
Y
F
I
G
N
L
A
L
S
D
L
L
A
G
---
V
-
A
Y
T
A
N
L
L
L
S
-
G
--
A
T
T
Y
K
L
T
P
A
Q
W
F
L
R
--
E
G
S
M
F
V
A
------
L
------
S
A
S
V
F
S
L
L
A
I
A
I
E
R
Y
I
T
M
-
L
K
-----------
N
N
F
R
L
F
L
L
I
S
A
C
W
V
I
S
L
I
L
G
G
L
P
I
M
--
G
W
--------
N
--------------
C
I
S
-----
A
L
------
S
S
---
C
--
S
T
V
-------
L
P
L
Y
H
K
----
H
Y
I
-
L
-
F
C
T
T
V
F
T
L
L
L
L
S
I
V
I
L
---
Y
C
R
I
Y
S
L
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
R
N
I
-----
F
-------
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
L
N
A
A
K
------
S
E
L
----
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
A
K
S
R
2
PsiBlast_PDB
77.72
42%
-173
- C1 -
3V2Y
2
ENLYS_BPT4
A:
[41-343]
---------------
D
I
--
I
V
R
H
Y
N
Y
T
G
K
L
--
N
I
S
A
D
K
E
N
S
I
K
L
T
S
V
V
F
I
L
I
C
C
F
I
I
L
E
N
I
F
V
L
L
T
I
W
K
T
K
K
F
H
R
P
M
Y
Y
F
I
G
N
L
A
L
S
D
L
L
A
G
---
V
-
A
Y
T
A
N
L
L
L
S
-
G
--
A
T
T
Y
K
L
T
P
A
Q
W
F
L
R
--
E
G
S
M
F
V
A
------
L
------
S
A
S
V
F
S
L
L
A
I
A
I
E
R
Y
I
T
M
-
L
K
-----------
N
N
F
R
L
F
L
L
I
S
A
C
W
V
I
S
L
I
L
G
G
L
P
I
M
--
G
W
--------
N
--------------
C
I
S
-----
A
L
------
S
S
---
C
--
S
T
V
-------
L
P
L
Y
H
K
----
H
Y
I
-
L
-
F
C
T
T
V
F
T
L
L
L
L
S
I
V
I
L
---
Y
C
R
I
Y
S
L
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
R
N
I
-----
F
-------
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
T
E
G
Y
Y
T
I
G
I
G
H
L
L
T
K
S
P
S
L
N
A
A
K
------
S
E
L
----
D
K
A
I
G
R
N
T
N
G
V
I
T
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
L
D
A
V
R
R
A
A
L
I
N
M
V
F
Q
M
G
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
K
R
W
D
E
A
A
V
N
L
A
K
S
R
34
HHSearch
75.87
23%
-174
- C1 -
3EML
13
ENLYS_BPT4
A:
[21-472]
----------------------------------------
S
-
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
A
V
G
---
V
-
L
A
I
P
F
A
I
T
I
-
S
--
T
-
G
F
C
A
A
C
H
G
C
L
F
I
--
A
C
F
V
L
V
L
------
T
------
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
-
R
I
P
L
R
Y
N
G
L
V
---
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
--
G
W
--------
N
--------------
N
C
G
-----
Q
S
------
Q
G
---
C
--
G
E
G
QVACLFE
D
V
V
P
M
N
----
Y
M
V
Y
F
-
N
F
F
A
C
V
L
V
P
L
L
L
M
L
G
V
---
Y
L
R
I
F
L
A
A
R
R
Q
L
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTW
D
A
Y
-
R
S
-
T
L
Q
K
E
V
H
A
-----
A
-------
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
A
P
L
W
L
M
Y
-
L
A
I
V
L
S
H
T
----
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
------------------------------------------------------------
35
HHSearch
74.19
25%
-165
- C1 -
3PBL
2
DRD3_HUMAN (first)
A:
[41-472]
--------------------------------------------
Y
A
L
S
Y
C
A
L
I
L
A
I
V
F
G
N
G
L
V
C
M
A
V
L
K
E
R
A
L
Q
T
T
T
N
Y
L
V
V
S
L
A
V
A
D
L
L
V
A
---
T
-
L
V
M
P
W
V
V
Y
L
-
E
V
T
G
G
V
W
N
F
S
R
I
C
C
D
V
F
--
V
T
L
D
V
M
M
------
C
------
T
A
S
I
W
N
L
C
A
I
S
I
D
R
Y
T
A
V
-
V
M
P
V
H
Y
Q
H
G
T
G
Q
S
S
C
R
R
V
A
L
M
I
T
A
V
W
V
L
A
F
A
V
S
C
P
L
L
F
--
G
F
--------
N
--------------
T
T
G
-----
D
P
------
T
V
---
C
--
S
I
S
-------
N
P
D
-------
F
V
I
-
Y
-
S
S
V
V
S
F
Y
L
P
F
G
V
T
V
L
V
---
Y
A
R
I
Y
V
V
L
K
Q
R
R
R
K
N
I
F
E
M
L
R
I
D
E
GLRL
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
T
GTWDA
Y
G
-
V
P
L
R
E
K
K
A
-----
T
-------
Q
M
V
A
I
V
L
G
A
F
I
V
C
W
L
P
F
F
L
T
H
V
L
N
T
H
C
Q
T
C
-
H
V
S
P
E
L
Y
S
-
A
T
T
W
L
G
Y
V
----
N
S
A
L
N
P
V
I
Y
T
T
F
N
I
E
F
R
K
A
F
L
K
I
L
S
C
-----------------------------------------------------------------
20
PsiBlast_PDB
73.17
27%
-171
- C1 -
2YCZ
2
ADRB1_MELGA
A:
[15-297]
---------------------------------------------
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
-
P
F
G
A
T
L
V
V
R
-
G
----
T
W
L
W
G
S
F
L
C
E
L
W
--
T
S
L
D
V
L
C
------
V
------
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
-
T
S
P
F
R
Y
Q
S
L
M
---
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
RDED
P
Q
A
L
K
--------------
C
Y
Q
-----
D
-------
P
G
---
C
--
C
D
F
-------
V
T
N
R
A
Y
----
A
I
A
-
S
-
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
---
L
-
R
V
Y
R
E
A
K
E
Q
I
R
K
I
D
R
------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
-
K
R
K
R
V
M
L
M
R
E
H
K
A
L
-------
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
V
P
D
W
L
F
V
A
---
F
N
W
L
G
Y
A
----
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
-----------------------------------------------------------------
19
PsiBlast_PDB
72.45
27%
-170
- C1 -
2YCX
3
ADRB1_MELGA
A:
[15-294]
---------------------------------------------
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
-
P
F
G
A
T
L
V
V
R
-
G
----
T
W
L
W
G
S
F
L
C
E
L
W
--
T
S
L
D
V
L
C
------
V
------
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
-
T
S
P
F
R
Y
Q
S
L
M
---
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
RDED
P
Q
A
L
K
--------------
C
Y
Q
-----
D
-------
P
G
---
C
--
C
D
F
-------
V
T
N
R
A
Y
----
A
I
A
-
S
-
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
---
L
-
R
V
Y
R
E
A
K
E
Q
I
R
K
I
D
R
------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
-
K
R
K
R
V
M
L
M
R
E
H
KA
L
-------
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
V
P
D
W
L
F
V
A
---
F
N
W
L
G
Y
A
----
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
----------------------------------------------------------------------
33
HHSearch
72.43
23%
-159
- C1 -
2RH1
16
ADRB2_HUMAN (first)
A:
[36-477]
------------------------------------
D
E
V
W
V
-
V
G
M
G
I
V
M
S
L
I
V
L
A
I
V
F
G
N
V
L
V
I
T
A
I
A
K
F
E
R
L
Q
T
V
T
N
Y
F
I
T
S
L
A
C
A
D
L
V
M
G
---
L
-
A
V
V
P
F
G
A
A
H
-
I
L
-
M
K
M
W
T
F
G
N
F
W
C
E
F
W
--
T
S
I
D
V
L
C
------
V
------
T
A
S
I
E
T
L
C
V
I
A
V
D
R
Y
F
A
I
-
T
S
P
F
K
Y
Q
S
L
L
---
T
K
N
K
A
R
V
I
I
L
M
V
W
I
V
S
G
L
T
S
F
L
P
I
Q
M
-
H
W
--------
Y
--------------
R
A
T
H
Q
---
E
A
I
N
C
Y
A
E
E
T
---
C
--
C
D
F
-------
F
T
--
N
Q
----
A
Y
A
-
I
A
S
S
I
V
S
F
Y
V
P
L
V
I
M
V
F
V
---
Y
S
R
V
F
Q
E
A
K
R
Q
L
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEGYYTIGIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
N
A
K
L
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDA--
Y
K
-
F
C
L
K
E
H
K
A
-----
L
-------
K
T
L
G
I
I
M
G
T
F
T
L
C
W
L
P
F
F
I
V
N
I
V
H
V
I
Q
D
N
L
--
I
R
K
E
V
Y
I
-
L
L
N
W
I
G
Y
V
----
N
S
G
F
N
P
L
I
Y
C
-
R
S
P
D
F
R
I
A
F
Q
E
L
L
C
L
-----------------------------------------------------------------
18
PsiBlast_PDB
71.90
27%
-175
- C1 -
2YCW
7
ADRB1_MELGA
A:
[15-297]
---------------------------------------------
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
-
P
F
G
A
T
L
V
V
R
-
G
----
T
W
L
W
G
S
F
L
C
E
L
W
--
T
S
L
D
V
L
C
------
V
------
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
-
T
S
P
F
R
Y
Q
S
L
M
---
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
RDED
P
Q
A
L
K
--------------
C
Y
Q
-----
D
-------
P
G
---
C
--
C
D
F
-------
V
T
N
R
A
Y
----
A
I
A
-
S
-
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
---
L
-
R
V
Y
R
E
A
K
E
Q
I
R
K
I
D
R
------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
-
K
R
K
R
V
M
L
M
R
E
H
KA
L
-------
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
V
P
D
W
L
F
V
A
---
F
N
W
L
G
Y
A
----
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
F
-----------------------------------------------------------------
47
Fugue
71.81
18%
-121
- C1 -
1F88
8
OPSD_BOVIN
A:
[1-348]
M
N
G
T
E
G
P
N
F
Y
V
P
F
S
N
K
T
GV
V
R
S
P
F
E
A
P
Q
Y
Y
L
A
E
----
P
W
Q
F
-
S
M
L
A
A
Y
M
F
L
L
I
M
L
G
F
P
I
N
F
L
T
L
Y
V
T
V
Q
H
K
K
L
R
T
P
L
N
Y
I
L
L
N
L
A
V
A
D
L
F
M
V
---
F
G
G
F
T
T
T
L
Y
T
S
-
L
--
H
G
Y
F
V
F
G
P
T
G
C
N
L
E
--
G
F
F
A
T
L
G
------
G
------
E
I
A
L
W
S
L
V
V
L
A
I
E
R
Y
V
V
V
-
C
K
P
M
S
N
F
R
-
F
---
G
E
N
H
A
I
M
G
V
A
F
T
W
V
M
A
L
A
C
A
A
P
P
L
V
--
G
W
--------
S
----------------
R
-----
Y
I
------
P
E
GMQ
C
--
S
C
G
-------
I
D
Y
Y
T
P
HEET
N
N
E
-
S
-
F
V
I
Y
M
F
V
V
H
F
I
I
P
L
I
V
---
I
F
F
C
Y
G
Q
L
V
F
T
V
K
E
A
A
A
S-----------------------------------------------------------------------------------------------------------------------------------------------------------
A
T
-
T
Q
K
A
E
K
E
V
-----
T
-------
R
M
V
I
I
M
V
I
A
F
L
I
C
W
L
P
-
Y
A
G
V
A
F
Y
I
F
T
H
Q
G
S
D
F
G
P
I
F
M
T
-
I
P
A
F
F
A
K
T
----
S
A
V
Y
N
P
V
I
Y
I
M
M
N
K
Q
F
R
N
C
M
V
T
T
L
C
C
------------------
G
K
N
P
S
T
T
V
S
K
T
E
T
S
Q
V
A
P
A
----------------------------
32
HHSearch
71.38
23%
-163
- C1 -
3RZE
5
ENLYS_BPT4 (first)
A:
[9-443]
------------------------------------------
M
P
L
V
V
V
L
S
T
I
C
L
V
T
V
G
L
N
L
L
V
L
Y
A
V
R
S
E
R
K
L
H
T
V
G
N
L
Y
I
V
S
L
S
V
A
D
L
I
V
G
---
A
-
V
V
M
P
M
N
I
L
Y
L
L
--
M
S
K
W
S
L
G
R
P
L
C
L
F
W
--
L
S
M
D
Y
V
A
------
S
------
T
A
S
I
F
S
V
F
I
L
C
I
D
R
Y
R
S
V
-
Q
Q
P
L
R
Y
L
K
Y
R
---
T
K
T
R
A
S
A
T
I
L
G
A
W
F
L
S
F
L
W
V
I
P
I
L
---
G
W
--------
N
--------------
H
--R----
R
E
------
D
K
---
C
--
E
T
D
-------
F
Y
D
V
-
T
----
W
F
K
-
V
M
T
A
I
I
N
F
Y
L
P
T
L
L
M
L
W
F
---
Y
A
K
I
Y
K
A
V
R
Q
H
C
N
I
F
E
M
L
R
I
D
E
G
L
R
L
K
I
Y
K
D
TEG
Y
Y
T
I
G
IGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDA--
Y
L
-
H
M
N
R
E
R
K
A
-----
A
-------
K
Q
L
G
F
I
M
A
A
F
I
L
C
W
I
P
Y
F
I
F
F
M
V
I
A
F
C
K
N
C
--
C
N
E
H
L
H
M
-
F
T
I
W
L
G
Y
I
----
N
S
T
L
N
P
L
I
Y
P
L
C
N
E
N
F
K
K
T
F
K
R
I
L
H
I
-----------------------------------------------------------------
17
PsiBlast_PDB
70.44
27%
-181
- C1 -
2VT4
8
ADRB1_MELGA
A:
[15-297]
---------------------------------------------
S
L
L
M
A
L
V
V
L
L
I
V
A
G
N
V
L
V
I
A
A
I
G
S
T
Q
R
L
Q
T
L
T
N
L
F
I
T
S
L
A
C
A
D
L
V
V
G
L
L
V
V
-
P
F
G
A
T
L
V
V
R
-
G
----
T
W
L
W
G
S
F
L
C
E
L
W
--
T
S
L
D
V
L
C
------
V
------
T
A
S
I
E
T
L
C
V
I
A
I
D
R
Y
L
A
I
-
T
S
P
F
R
Y
Q
S
L
M
---
T
R
A
R
A
K
V
I
I
C
T
V
W
A
I
S
A
L
V
S
F
L
P
I
M
M
H
W
W
RDED
P
Q
A
L
K
--------------
C
Y
Q
-----
D
-------
P
G
---
C
--
C
D
F
-------
V
T
N
R
A
Y
----
A
I
A
-
S
-
S
I
I
S
F
Y
I
P
L
L
I
M
I
F
V
A
---
L
-
R
V
Y
R
E
A
K
E
Q
I
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
H
K
A
-
L
-------
K
T
L
G
I
I
M
G
V
F
T
L
C
W
L
P
F
F
L
V
N
I
V
N
V
F
N
R
D
L
V
P
D
W
L
F
V
A
---
F
N
W
L
G
Y
A
----
N
S
A
M
N
P
I
I
Y
C
-
R
S
P
D
F
R
K
A
F
K
R
L
L
A
------------------------------------------------------------------
13
PsiBlast_PDB
68.92
25%
-154
- C1 -
3REY
1
AA2AR_HUMAN
A:
[7-303]
------------------------------------------
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
---
V
-
L
------------
A
I
P
F
A
I
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
------
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
-
V
---
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
--
G
W
--------
N
NCGQPG--------
C
G
E
-----
G
Q
------
V
A
---
C
L
F
E
D
V
-------
V
P
M
N
Y
M
----
V
Y
F
-
N
-
F
----
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
P
L
P
G
E
R
A
R
S
T
-----
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
A
P
L
W
L
M
Y
-
L
A
I
V
L
A
H
T
----
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-----------------------------------------------------------------
12
PsiBlast_PDB
68.47
25%
-152
- C1 -
3PWH
1
?
A:
[7-303]
------------------------------------------
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
---
V
-
L
------------
A
I
P
F
A
I
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
------
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
-
V
---
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
--
G
W
--------
N
NCGQPG--------
C
G
E
-----
G
Q
------
V
A
---
C
LF
E
D
V
-------
V
P
M
N
Y
M
----
V
Y
F
-
N
-
F
----
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
P
L
P
G
E
R
A
R
S
T
-----
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
A
P
L
W
L
M
Y
-
L
A
I
V
L
A
H
T
----
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-----------------------------------------------------------------
15
PsiBlast_PDB
68.25
25%
-156
- C1 -
3UZA
1
AA2AR_HUMAN
A:
[7-303]
------------------------------------------
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
---
V
-
L
------------
A
I
P
F
A
I
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
------
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
-
V
---
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
--
G
W
--------
N
NCGQPG--------
C
G
E
-----
G
Q
------
V
A
---
C
L
F
E
D
V
-------
V
P
M
N
Y
M
----
V
Y
F
-
N
-
F
----
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
P
L
P
G
E
R
A
R
S
T
-----
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
A
P
L
W
L
M
Y
-
L
A
I
V
L
A
H
T
----
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-----------------------------------------------------------------
29
HHSearch
67.58
21%
-160
- C1 -
3UON
4
ACM2_HUMAN (first)
A:
[23-457]
----------------------------------------
V
-
V
F
I
V
L
V
A
G
S
L
S
L
V
T
I
I
G
N
I
L
V
M
V
S
I
K
V
N
R
H
L
Q
T
V
N
N
Y
F
L
F
S
L
A
C
A
D
L
I
I
G
---
V
-
F
S
M
N
L
Y
T
L
Y
T
V
--
I
G
Y
W
P
L
G
P
V
V
C
D
L
W
--
L
A
L
D
Y
V
V
------
S
------
N
A
S
V
M
N
L
L
I
I
S
F
D
R
Y
F
C
V
-
T
K
P
L
T
Y
P
V
K
R
---
T
T
K
M
A
G
M
M
I
A
A
A
W
V
L
S
F
I
L
W
A
P
A
I
L
--
F
W
--------
Q
--------------
F
I
V
GVRTV
E
D
------
G
E
---
C
--
Y
I
Q
-------
F
F
S
N
A
A
----
V
T
F
-
G
-
T
A
I
A
A
F
Y
L
P
V
I
I
M
T
V
L
---
Y
W
H
I
S
R
A
S
K
S
R
I
N
I
F
E
M
L
R
I
D
EGLRL
K
I
Y
K
D
TEG
Y
Y
T
I
GIGHLLTKSPS
L
N
A
A
K
S
E
L
D
K
A
I
GRNTNGVIT
K
D
E
A
E
K
L
F
N
Q
D
V
D
A
A
V
R
G
I
L
R
NAKL
K
P
V
Y
D
S
LD
A
V
R
R
A
A
L
I
N
M
V
F
Q
MG
E
T
G
V
A
G
F
T
N
S
L
R
M
L
Q
Q
KR
W
D
E
A
A
V
N
L
A
K
S
R
W
Y
N
Q
T
P
N
R
A
K
R
V
I
T
T
F
R
TGTWDA--
Y
P
-
P
P
S
R
E
K
K
V
-----
T
-------
R
T
I
L
A
I
L
L
A
F
I
I
T
W
A
P
Y
N
V
M
V
L
I
N
T
F
C
A
P
C
--
I
P
N
T
V
W
T
-
I
G
Y
W
L
C
Y
I
----
N
S
T
I
N
P
A
C
Y
A
L
C
N
A
T
F
K
K
T
F
K
H
L
L
M
------------------------------------------------------------------
16
PsiBlast_PDB
67.56
25%
-154
- C1 -
3UZC
1
AA2AR_HUMAN
A:
[7-303]
------------------------------------------
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
---
V
-
L
------------
A
I
P
F
A
I
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
------
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
-
V
---
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
--
G
W
--------
N
NCGQPG--------
C
G
E
-----
G
Q
------
V
A
---
C
L
F
E
D
V
-------
V
P
M
N
Y
M
----
V
Y
F
-
N
-
F
----
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
P
L
P
G
E
R
A
R
S
T
-----
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
A
P
L
W
L
M
Y
-
L
A
I
V
L
A
H
T
----
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-----------------------------------------------------------------
14
PsiBlast_PDB
66.31
25%
-153
- C1 -
3RFM
1
AA2AR_HUMAN
A:
[7-303]
------------------------------------------
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
L
A
A
A
D
I
L
V
G
---
V
-
L
------------
A
I
P
F
A
I
T
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
------
C
F
V
L
V
L
A
Q
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
A
I
P
L
R
Y
N
G
L
-
V
---
T
G
T
R
A
A
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
--
G
W
--------
N
NCGQPG--------
C
G
E
-----
G
Q
------
V
A
---
C
L
F
E
D
V
-------
V
P
M
N
Y
M
----
V
Y
F
-
N
-
F
----
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
A
A
A
R
R
Q
L
K
Q
M
E
S
------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
P
L
P
G
E
R
A
R
S
T
-----
L
Q
K
E
V
H
A
A
K
S
A
A
I
I
A
G
L
F
A
L
C
W
L
P
L
H
I
I
N
C
F
T
F
F
C
P
D
C
S
H
A
P
L
W
L
M
Y
-
L
A
I
V
L
A
H
T
----
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
-----------------------------------------------------------------
9
PsiBlast_PDB
65.63
25%
-147
- C1 -
4UHR
1
AA2AR_HUMAN
A:
[6-303]
----------------------------------------
S
-
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
---
V
-
L
------------
A
I
P
F
A
I
A
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
------
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
-
V
---
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
--
G
W
--------
N
NCGQPKEGKAG---
C
G
E
-----
G
Q
------
V
A
---
C
LF
E
D
V
-------
V
P
M
N
Y
M
----
V
Y
F
-
N
-
F
----
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
P
L
P
G
E
R
A
R
S
T
-----
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
-----
I
N
C
F
T
F
F
C
P
D
C
-
H
A
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
--
Q
E
P
F
K
A
A
A
A
-------------------------------------------------
7
PsiBlast_PDB
65.54
25%
-151
- C1 -
2YDV
6
?
A:
[5-303]
---------------------------------------
G
S
-
S
V
Y
I
T
V
E
L
A
I
A
V
L
A
I
L
G
N
V
L
V
C
W
A
V
W
L
N
S
N
L
Q
N
V
T
N
Y
F
V
V
S
A
A
A
A
D
I
L
V
G
---
V
-
L
------------
A
I
P
F
A
I
A
I
S
T
G
F
C
A
A
C
H
G
C
L
F
I
A
C
F
V
L
V
L
T
------
A
S
S
I
F
S
L
L
A
I
A
I
D
R
Y
I
A
I
R
I
P
L
R
Y
N
G
L
-
V
---
T
G
T
R
A
K
G
I
I
A
I
C
W
V
L
S
F
A
I
G
L
T
P
M
L
--
G
W
--------
N
NCGQPK
E
G
K
A
H
S
Q
G
C
G
E
-----
G
Q
------
V
A
---
C
LF
E
D
V
-------
V
P
M
N
Y
M
----
V
Y
F
-
N
-
F
----
F
A
C
V
L
V
P
L
L
L
M
L
G
V
Y
L
R
I
F
L
A
A
R
R
Q
L
K
Q
M
E
S
------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
--------
S
T
-----
L
Q
K
E
V
H
A
A
K
S
L
A
I
I
V
G
L
F
A
L
C
W
L
P
L
H
I
-----
I
N
C
F
T
F
F
C
P
D
C
S
H
A
P
L
W
L
M
Y
L
A
I
V
L
S
H
T
N
S
V
V
N
P
F
I
Y
A
Y
R
I
R
E
F
R
Q
T
F
R
K
I
I
R
S
H
V
L
R
Q
--
Q
E
P
F
K
A
A
A
A
E
N
L
Y
F
Q
-------------------------------------------