@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : TS1R1_HUMAN: (2016-01-15 )
MLLCTARLVGLQLLISCCWAFACHSTESSPDFTLPGDYLLAGLFPLHSGCLQVRHRPEVTLCDRSCSFNEHGYHLFQAMRLGVEEINNSTALLPNITLGYQLYDVCSDSANVYATLRVLSLPGQHHIELQGDLLHYSPTVLAVIGPDSTNRAATTAALLSPFLVPMISYAASSETLSVKRQYPSFLRTIPNDKYQVETMVLLLQKFGWTWISLVGSSDDYGQLGVQALENQATGQGICIAFKDIMPFSAQVGDERMQCLMRHLAQAGATVVVVFSSRQLARVFFESVVLTNLTGKVWVASEAWALSRHITGVPGIQRIGMVLGVAIQKRAVPGLKAFEEAYARADKKAPRPCHKGSWCSSNQLCRECQAFMAHTMPKLKAFSMSSAYNAYRAVYAVAHGLHQLLGCASGACSRGRVYPWQLLEQIHKVHFLLHKDTVAFNDNRDPLSSYNIIAWDWNGPKWTFTVLGSSTWSPVQLNINETKIQWHGKDNQVPKSVCSSDCLEGHQRVVTGFHHCCFECVPCGAGTFLNKSDLYRCQPCGKEEWAPEGSQTCFPRTVVFLALREHTSWVLLAANTLLLLLLLGTAGLFAWHLDTPVVRSAGGRLCFLMLGSLAAGSGSLYGFFGEPTRPACLLRQALFALGFTIFLSCLTVRSFQLIIIFKFSTKVPTFYHAWVQNHGAGLFVMISSAAQLLICLTWLVVWTPLPAREYQRFPHLVMLECTETNSLGFILAFLYNGLLSISAFACSYLGKDLPENYNEAKCVTFSLLFNFVSWIAFFTTASVYDGKYLPAANMMAGLSSLSSGFGGYFLPKCYVILCRPDLNSTEHFQASIQDYTRRCGST
Atome Classification :
(20 SA)
.........10........20........30........40........50........-60......--.--.-70.........80........90........100.......110....----....120----........130......-.140.......150.......160.......170.......180.......190.......200.......210.......220.......230........240.........250.....----..260..-..-.-..270.......280.......290...-.-...300.......310.......320.-....-..330......-----------..340-.....-.---------..---------350.....---------------..---360..-.....370.......380......-.390--------.........400--.--..----------..--.----.----.--.----410-.-..-....420-...-.....430------..--.-.-------.---...440.------------......450...-.-...460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
L
L
C
T
A
R
L
V
G
L
Q
L
L
I
S
C
C
W
A
F
ACHSTESSPDFTL
P
G
D
Y
L
L
A
G
L
F
P
L
H
S
G
C
L
Q
V
RHRPE
V
-
T
L
CDRSCS--F--N-E-
H
G
Y
H
L
F
Q
A
M
R
L
G
V
E
EINNSTALLPN
I
T
L
G
Y
Q
L
Y
D
V
CSDSA-
N
V
Y
A
T
----
L
R
V
L
SL-----PGQ
H
H
I
E
L
QG
D
L
L
HYS
P
-
T
V
L
A
V
IGPDSTNR
A
A
T
T
A
A
L
L
S
P
F
L
V
P
M
I
S
YAASSE
T
L
S
V
K
R
Q
Y
P
S
F
L
R
TIPNDK
Y
Q
V
E
T
M
V
L
L
L
Q
KFG
W
T
W
I
S
L
VGSSD
D
Y
G
Q
L
G
V
Q
A
L
EN-QATGQ
G
I
C
I
A
--
F
K
DIMPFSAQV
G
D
E
R
M
Q
----
C
L
M
R
H
L
A
-QA-G-
A
T
V
V
V
V
FSS
R
Q
L
A
R
V
F
F
E
S
V
V
L
TNLTG
K
-
V
-
W
V
A
S
E
A
W
A
L
S
R
HITGV
P
G
I
Q
R
I
G
M
V
L
G
-
V
A
I
Q
-
K
RA-VP
G
L
K
A
F
-----------
E
E
A
Y
--
A
RADK-K---------AP---------RPCHKGSW---------------CS---
S
N
Q
L
C
-
R
E
C
Q
A
F
M
A
HT
M
P
K
L
K
A
F
S
M
S
S
A
Y
N
-
A
Y
----------
R
A
V
Y
A
V
A
H
G
L
----
H
--
Q
L
----------
L
G
--C----A----S--G----ACS-R-GR-V
Y
P
W
Q
-
L
-
L
E
Q
-
I
H
K
V
H
F
L
-------
L
H--K-
D
-------
T
---
V
A
FNDNR------------DPLSSY
N
I
I
A
W
D-W-NGP
K
W
T
F
T
V
LGSSTWS
P
V
Q
L
NIN
E
T
K
I
Q
WHGKDNQV
P
K
S
V
C
S
S
D
C
L
E
G
H
Q
R
V
V
T
G
F
H
H
C
C
F
E
CVPCGAGTFLNKSD
L
Y
RCQPCGKEEWAPEGSQTCF
P
R
T
V
V
F
L
A
L
REHT
S
W
V
L
L
A
A
N
T
L
L
L
L
L
L
LGTA
G
L
F
A
WHLDT
P
V
V
RSAG
G
R
L
C
F
L
M
L
G
S
LAAGSG
S
L
Y
G
FFGEPT
R
P
A
C
L
L
R
Q
A
L
F
A
L
G
F
T
I
F
L
S
C
L
T
VR
S
F
Q
L
I
I
I
F
KFSTKV
P
T
F
Y
H
A
W
V
Q
NHGA
G
L
F
V
M
I
S
S
A
A
Q
L
L
I
C
L
T
W
L
V
V
WTPL
P
A
R
E
Y
Q
RFP
H
L
V
M
L
E
CTETN
S
L
G
F
I
L
A
F
L
Y
N
G
L
L
S
I
S
A
F
A
C
S
Y
L
G
K
DLPENYNE
A
K
C
V
T
F
S
L
L
F
N
F
V
S
W
I
A
F
F
T
TASVYDGKYL
P
A
A
N
M
M
A
G
L
S
S
L
S
SGFG
G
Y
F
L
P
K
C
Y
V
I
L
CRPDLN
S
T
E
H
F
Q
A
S
I
Q
D
Y
T
R
RCGST
5
PsiBlast_PDB
96.18
26%
-113
- C1 -
2E4Y
2
GRM3_RAT
A:
[8-539]
------------------------------
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
G
T
E
E
-------
C
G
R
-----
I
--
N
-
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
--
R
-
D
T
Y
A
L
----
E
Q
S
L
E
F
V
R
A
S
L---------
I
P
L
L
------
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
-
E
A
R
L
R
N
I
C
I
A
--------
T
A
E
K
V
G
R
S
N
I
R
K
S
Y
D
S
V
I
R
E
L
L
-
Q
K
P
N
-
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
A
S
F
--
T
-
W
V
A
S
D
G
W
G
A
Q
E
S
I
--
V
K
G
S
E
H
V
A
--
Y
G
-
A
I
T
L
-
E
L
A
-
S
H
P
V
R
Q
F
-----------
D
R
Y
F
--
Q
S
L
N
-------------
P
---------
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q-----
C
S
---
L
Q
N
K
R
-
N
H
R
Q
V
C
D
K
H
L
A
I
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
----------
N
A
V
Y
A
M
A
H
A
L
----
H
--
K
M
----------
Q
R
--
T
L
C
PQ
T
----
T
--
K
----
L
C
D
-
A
-
M
K
-
I
L
D
G
K
-----
K
-
L
Y
K
E
Y
L
L
-------
K
I
--
Q
-
F
-------
T
---
A
P
F
N
P
N
K
GADS
I
V
K
F
D
TFG
D
G
M
G
R
Y
N
V
F
N
L
Q
-
Q
-
T
G
G
K
Y
S
Y
L
K
V
G
H
--
W
A
E
T
-
L
S
L
D
V
D
S
I
H
W
--
S
R
N
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
--
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
93.99
26%
-114
- C1 -
2E4W
2
GRM3_RAT
A:
[8-539]
------------------------------
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
G
T
E
E
-------
C
G
R
-----
I
--
N
-
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
--
R
-
D
T
Y
A
L
----
E
Q
S
L
E
F
V
R
A
S
L---------
I
P
L
L
------
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
-
E
A
R
L
R
N
I
C
I
A
--------
T
A
E
K
V
G
R
S
N
I
R
K
S
Y
D
S
V
I
R
E
L
L
-
Q
K
P
N
-
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
A
S
F
--
T
-
W
V
A
S
D
G
W
G
A
Q
E
S
I
--
V
K
G
S
E
H
V
A
--
Y
G
-
A
I
T
L
-
E
L
A
-
S
H
P
V
R
Q
F
-----------
D
R
Y
F
--
Q
S
L
N
-------------
P
---------
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q-----
C
S
---
L
Q
N
K
R
-
N
H
R
Q
V
C
D
K
H
L
A
I
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
----------
N
A
V
Y
A
M
A
H
A
L
----
H
--
K
M
----------
Q
R
--
T
L
C
PQ
T
----
T
--
K
----
L
C
D
-
A
-
M
K
-
I
L
D
G
K
-----
K
-
L
Y
K
E
Y
L
L
-------
K
I
--
Q
-
F
-------
T
---
A
P
F
N
P
N
K
GADS
I
V
K
F
D
TFG
D
G
M
G
R
Y
N
V
F
N
L
Q
-
Q
-
T
G
G
K
Y
S
Y
L
K
V
G
H
--
W
A
E
T
-
L
S
L
D
V
D
S
I
H
W
--
S
R
N
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
--
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
93.40
26%
-110
- C1 -
2E4X
2
GRM3_RAT
A:
[8-539]
------------------------------
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
G
T
E
E
-------
C
G
R
-----
I
--
N
-
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
--
R
-
D
T
Y
A
L
----
E
Q
S
L
E
F
VRASL---------
I
P
L
L
------
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
-
E
A
R
L
R
N
I
C
I
A
--------
T
A
E
K
V
G
R
S
N
I
R
K
S
Y
D
S
V
I
R
E
L
L
-
Q
K
P
N
-
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
A
S
F
--
T
-
W
V
A
S
D
G
W
G
A
Q
E
S
I
--
V
K
G
S
E
H
V
A
--
Y
G
-
A
I
T
L
-
E
L
A
-
S
H
P
V
R
Q
F
-----------
D
R
Y
F
--
Q
S
L
N
-------------
P
---------
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q-----
C
S
---
L
Q
N
K
R
-
N
H
R
Q
V
C
D
K
H
L
A
I
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
----------
N
A
V
Y
A
M
A
H
A
L
----
H
--
K
M
----------
Q
R
--
T
L
C
PQ
T
----
T
--
K
----
L
C
D
-
A
-
M
K
-
I
L
D
G
K
-----
K
-
L
Y
K
E
Y
L
L
-------
K
I
--
Q
-
F
-------
T
---
A
P
F
N
P
N
K
GADS
I
V
K
F
D
TFG
D
G
M
G
R
Y
N
V
F
N
L
Q
-
Q
-
T
G
G
K
Y
S
Y
L
K
V
G
H
--
W
A
E
T
-
L
S
L
D
V
D
S
I
H
W
--
S
R
N
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
--
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
93.23
26%
-110
- C1 -
2E4V
2
GRM3_RAT
A:
[8-539]
------------------------------
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
G
T
E
E
-------
C
G
R
-----
I
--
N
-
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
--
R
-
D
T
Y
A
L
----
E
Q
S
L
E
F
VRASL---------
I
P
L
L
------
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
-
E
A
R
L
R
N
I
C
I
A
--------
T
A
E
K
V
G
R
S
N
I
R
K
S
Y
D
S
V
I
R
E
L
L
-
Q
K
P
N
-
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
A
S
F
--
T
-
W
V
A
S
D
G
W
G
A
Q
E
S
I
--
V
K
G
S
E
H
V
A
--
Y
G
-
A
I
T
L
-
E
L
A
-
S
H
P
V
R
Q
F
-----------
D
R
Y
F
--
Q
S
L
N
-------------
P
---------
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q-----
C
S
---
L
Q
N
K
R
-
N
H
R
Q
V
C
D
K
H
L
A
I
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
----------
N
A
V
Y
A
M
A
H
A
L
----
H
--
K
M
----------
Q
R
--
T
L
C
PQ
T
----
T
--
K
----
L
C
D
-
A
-
M
K
-
I
L
D
G
K
-----
K
-
L
Y
K
E
Y
L
L
-------
K
I
--
Q
-
F
-------
T
---
A
P
F
N
P
N
K
GADS
I
V
K
F
D
TFG
D
G
M
G
R
Y
N
V
F
N
L
Q
-
Q
-
T
G
G
K
Y
S
Y
L
K
V
G
H
--
W
A
E
T
-
L
S
L
D
V
D
S
I
H
W
--
S
R
N
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
--
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
93.23
26%
-113
- C1 -
2E4U
2
GRM3_RAT
A:
[8-539]
------------------------------
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
G
T
E
E
-------
C
G
R
-----
I
--
N
-
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
--
R
-
D
T
Y
A
L
----
E
Q
S
L
E
F
VRASL---------
I
P
L
L
------
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
-
E
A
R
L
R
N
I
C
I
A
--------
T
A
E
K
V
G
R
S
N
I
R
K
S
Y
D
S
V
I
R
E
L
L
-
Q
K
P
N
-
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
A
S
F
--
T
-
W
V
A
S
D
G
W
G
A
Q
E
S
I
--
V
K
G
S
E
H
V
A
--
Y
G
-
A
I
T
L
-
E
L
A
-
S
H
P
V
R
Q
F
-----------
D
R
Y
F
--
Q
S
L
N
-------------
P
---------
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q-----
C
S
---
L
Q
-------
Q
V
C
D
K
H
L
A
I
D
S
S
N
Y
E
Q
E
S
K
I
M
F
V
V
----------
N
A
V
Y
A
M
A
H
A
L
----
H
--
K
M
----------
Q
R
--
T
LCPQ
T
----
T
--
K
----
L
C
D
-
A
-
M
K
-
I
L
D
G
K
-----
K
-
L
Y
K
E
Y
L
L
-------
K
I
--
Q
-
F
-------
T
---
A
P
F
N
P
N
K
GADS
I
V
K
F
D
TFG
D
G
M
G
R
Y
N
V
F
N
L
Q
-
Q
-
T
G
G
K
Y
S
Y
L
K
V
G
H
--
W
A
E
T
-
L
S
L
D
V
D
S
I
H
W
--
S
R
N
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
--
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
85.58
26%
-119
- C1 -
3SM9
8
GRM3_HUMAN
A:
[7-474]
------------------------------
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
-
T
E
E
-------
C
G
R
-----
I
--
N
-
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
D
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
--
R
-
D
T
Y
A
L
----
E
Q
S
L
E
F
V
R
A
S------------
L
L
------
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
-
E
A
R
L
R
N
I
S
I
A
--------
T
A
E
K
V
G
R
--
I
R
K
S
Y
D
S
V
I
R
E
L
L
-
Q
K
P
N
-
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
S
R
A
N
A
S
F
--
T
-
W
V
A
S
D
G
W
G
A
Q
E
S
I
--
I
K
G
S
E
H
V
A
--
Y
G
-
A
I
T
L
-
E
L
A
-
S
Q
P
V
R
Q
F
-----------
D
R
Y
F
--
Q
S
L
N
-------------
P
---------
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q-----
C
S
LQN---
H
R
-
R
V
C
D
K
H
L
A
I
D
S
S
N
Y
E
--
Q
E
S
K
I
M
F
-
V
V
----------
N
A
V
Y
A
M
A
H
A
L
----
H
--
K
M
Q
R
T
LCPNTTK
L
C
--
D
----
A
----
M
--
K
----
I
L
D
-
G
-
K
K
-
L
Y
K
D
Y
-
L
-
L
K
I
-
N
F
T
A
P
F
N
----------------------D
S
I
V
K
F
D
T
F
G
------------
D
G
M
G
R
Y
N
V
F
N
F
Q
-
N
-
V
G
G
K
Y
S
Y
L
K
V
G
H
--
W
A
E
T
-
L
S
L
D
V
N
S
I
H
W
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
83.67
26%
-117
- C1 -
5CNM
5
?
A:
[34-497]
------------------------------
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
G
T
E
E
-------
C
G
R
-----
I
--
N
-
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
D
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
--
R
-
D
T
Y
A
L
----
E
Q
S
L
E
F
V
R
A
S
L---------
I
P
L
L
------
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
-
E
A
R
L
R
N
I
S
I
A
--------
T
A
E
K
V
G
---
I
R
K
S
Y
D
S
V
I
R
E
L
L
-
Q
K
P
N
-
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
S
R
A
N
A
S
F
--
T
-
W
V
A
S
D
G
W
G
A
Q
E
S
I
--
I
K
G
S
E
H
V
A
--
Y
G
-
A
I
T
L
-
E
L
A
-
S
Q
P
V
R
Q
F
-----------
D
R
Y
F
--
Q
S
L
N
-------------
P
---------
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q-----
C
S
LQN---
H
R
-
R
V
C
D
K
H
L
A
I
D
S
S
N
Y
E
--
Q
E
S
K
I
M
F
-
V
V
----------
N
A
V
Y
A
M
A
H
A
L
----
H
--
K
M
Q
R
T
L
C
PNTTK
L
C
--
D
----
A
----
M
--
K
----
I
L
D
-
G
-
K
K
-
L
Y
K
D
Y
-
L
-
L
K
I
-
N
F
T
A
P
F
N
-------
P
N
--
K
-
D
-------
A
DS
I
V
K
F
D
T
F
G
------------
D
G
M
G
R
Y
N
V
F
N
F
Q
--------
S
Y
L
K
V
G
H
--
W
A
E
T
-
L
S
L
D
V
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
83.60
26%
-106
- C1 -
2E4Z
1
GRM7_RAT
A:
[13-479]
---------------------------------
I
E
G
D
V
T
L
G
G
L
F
P
V
H
A
K
G
------
P
S
G
-
V
P
C
--
G
D
I
--
K
--
R
-
E
-
N
G
I
H
R
L
E
A
M
L
Y
A
L
D
Q
I
N
S
D
P
N
L
L
P
N
V
T
L
G
A
R
I
L
D
T
C
S
--
R
-
D
T
Y
A
L
----
E
Q
S
L
T
F
-----
V
Q
A
L
I
Q
K
---------
P
E
K
V
V
G
V
I
G
A
S
G
S
S
V
S
I
M
V
A
N
I
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
A
P
E
L
S
D
D
R
R
Y
D
F
F
S
R
V
V
P
P
D
S
F
Q
A
Q
A
M
V
D
I
V
K
A
L
G
W
N
Y
V
S
T
L
A
S
E
G
S
Y
G
E
K
G
V
E
S
F
T
Q
I
S
K
E
A
G
G
L
C
I
A
--
Q
S
V
R
I
P
------
T
I
D
F
D
----
R
I
I
K
Q
L
L
-
D
T
P
N
-
S
R
A
V
V
I
F
A
N
D
E
D
I
K
Q
I
L
A
A
A
K
R
A
D
Q
V
G
H
F
L
-
W
V
G
S
D
S
W
G
S
K
I
N
----
P
L
H
Q
H
E
D
I
A
E
G
A
I
T
I
Q
P
K
R
A
T
V
E
G
F
D
A
Y
-------------
F
T
--
S
R
T
L
E
-
N
---------
N
R
---------
R
N
V
W
F
A
E
Y
---------------
W
E
---
E
N
F
N
C
K-
K
C
T
G
--
Q
E
R
I
G
K
D
S
N
Y
E
Q
E
G
K
V
Q
F
V
I
----------
D
A
V
Y
A
M
A
H
A
L
----
H
--
H
M
----------
N
K
D
L
C
----------YR
G
----
V
C
P
-
E
M
E
Q
-
A
G
G
K
K
-
L
-
L
K
Y
-
I
R
H
V
N
F
N
-------
G
S
--
A
-
G
-------
T
P
--
V
M
F
N
K
N
G
------------
D
A
P
G
R
Y
D
I
F
Q
Y
Q
T
T
-
N
T
T
N
P
G
Y
R
L
I
G
Q
W
T
-
D
E
L
Q
L
N
I
E
D
--
M
Q
W
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
Fugue
83.28
26%
-96
- C1 -
2E4U
2
GRM3_RAT
A:
[6-543]
----------------------------
R
R
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
G
T
E
E
C
G
R
I
-
N
------------
E
-
D
-
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
-
Y
A
L
E
Q
----
S
L
E
F
V
R
-----
A
S
L
I
-----------
P
L
-
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
-
E
A
R
L
R
N
I
C
I
A
--
T
A
E
K
V
G
R
S
N
I
--
R
K
S
Y
D
----
S
V
I
R
E
L
L
-
Q
K
-
P
N
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
A
S
F
--
T
-
W
V
A
S
D
G
W
G
A
Q
E
S
I
V
K
-
G
S
E
H
V
A
Y
G
A
I
T
-
L
E
L
A
-
S
H
P
-
V
R
Q
F
D
R
Y
F
Q
S
LNPYNNH-
R
N
P
W
--
F
R
D
F
W
-
E
---------
Q
K
---------
F
Q
C
S
L
Q
Q
V
---------------
C
D
---
K
H
L
------------
A
I
D
S
S
N
Y
E
Q
E
S
K
I
M
F
-
V
V
----------
N
A
V
Y
A
M
A
H
A
L
----
H
--
K
M
----------
Q
R
--
T
----
L
CPQT
T
--
K
----
L
C
D
-
A
M
K
I
-
L
D
G
K
K
-
L
-
Y
K
E
Y
L
L
K
I
Q
F
T
-------
A
P
--
F
-
N
PNKGADS
I
---
V
K
F
D
T
F
G
------------
D
G
M
G
R
Y
N
V
F
N
L
Q
-
Q
-
T
G
G
K
Y
S
Y
L
K
V
G
--
H
W
A
E
-
T
L
S
L
D
V
D
S
I
H
W
S
R
--
N
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
--
E
Y
L
V
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
81.73
26%
-106
- C1 -
4XAR
9
GRM3_HUMAN
A:
[34-509]
------------------------------
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
G
T
E
E
-------
C
G
R
-----
I
--
N
-
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
D
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
--
R
-
D
T
Y
A
L
----
E
Q
S
L
E
F
V
R
ASL-----------
L
L
------
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
-
E
A
R
L
R
N
I
S
I
A
--------
T
A
E
K
V
G
R
S
N
I
R
KS
Y
D
S
V
I
R
E
L
L
-
Q
K
P
N
-
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
S
R
A
N
A
S
F
--
T
-
W
V
A
S
D
G
W
G
A
Q
E
S
I
--
I
K
G
S
E
H
V
A
--
Y
G
-
A
I
T
L
-
E
L
A
-
S
Q
P
V
R
Q
F
-----------
D
R
Y
F
--
Q
S
L
N
-------------
P
---------
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q-----
C
S
L--------
R
V
C
D
K
H
L
A
I
D
S
S
N
Y
E
--
Q
E
S
K
I
M
F
-
V
V
----------
N
A
V
Y
A
M
A
H
A
L
----
H
--
K
M
Q
R
T
L
C
PNTTK
L
C
--
D
----
A
----
M
--
K
----
I
L
D
-
G
-
K
K
-
L
Y
K
D
Y
-
L
-
L
K
I
-
N
F
T
A
P
---------------
D
-------
A
DS
I
V
K
F
D
T
F
G
------------
D
G
M
G
R
Y
N
V
F
N
F
Q
-
N
-
V
G
G
K
Y
S
Y
L
K
V
G
H
--
W
A
E
T
-
L
S
L
D
V
N
S
I
H
W
--
S
R
N
S
V
P
T
S
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
81.61
26%
-96
- C1 -
2E4U
2
GRM3_RAT
A:
[7-543]
-----------------------------
R
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
G
------
T
-
E
E
C
G
---
R
--
I
N-
E
-
D
-
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
N
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
----
L
E
F
V
R
A
-----
S
L
------------
I
P
L
-
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
-
E
A
R
L
R
N
I
C
I
A
--
T
A
E
K
V
G
R
S
N
I
--
R
K
S
Y
D
----
S
V
I
R
E
L
L
Q
K
P
-
N
-
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
N
R
V
N
A
-
S
F
-
T
-
W
V
A
S
D
G
W
G
A
Q
E
S
I
V
K
G
-
S
E
H
V
A
Y
G
A
I
T
-
L
E
L
A
-
S
H
P
-
V
R
Q
F
D
R
Y
-----------
F
Q
S
L
--
N
P
Y
N
N
H
R
---------
N
P
W
F
R
D
F
W
E
Q
K
F
Q
C
S
L
Q
------------------------
Q
V
C
-
D
K
H
L
A
I
D
S
S
N
-----
Y
E
Q
E
S
K
I
M
F
-
V
V
----------
N
A
V
Y
A
M
A
H
A
L
----
H
--
K
M
----------
Q
R
--
T
----
L
----
C
--
P
QTTK
L
C
D
A
M
-
K
I
-
L
D
G
K
K
-
L
Y
K
E
Y
-
L
L
K
I
Q
F
T
APFNPNK
G
A
--
D
-
S
-------
I
---
V
K
F
D
T
F
G
------------
D
G
M
G
R
Y
N
V
F
N
L
Q
-
Q
-
T
G
G
K
Y
S
Y
L
K
V
G
H
W
A
E
T
L
---
S
L
D
V
D
S
I
H
W
S
R
N
--
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
M
K
N
M
Q
P
G
D
V
C
C
W
I
C
I
P
C
E
P
Y
E
Y
L
V
--
D
E
F
T
C
M
D
C
G
P
G
Q
W
P
T
A
D
L
S
G
C
Y
N
L
P
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
80.87
26%
-105
- C1 -
5CNK
5
?
A:
[34-505]
------------------------------
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
G
T
E
E
-------
C
G
R
-----
I
--
N
-
E
D
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
D
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
--
R
-
D
T
Y
A
L
----
E
Q
S
L
E
F
V
R
ASL---------
I
P
L
L
------
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
-
E
A
R
L
R
N
I
S
I
A
--------
T
A
E
K
V
G
R
S
N
I
R
KS
Y
D
S
V
I
R
E
L
L
-
Q
K
P
N
-
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
S
R
A
N
A
S
F
--
T
-
W
V
A
S
D
G
W
G
A
Q
E
S
I
--
I
K
G
S
E
H
V
A
--
Y
G
-
A
I
T
L
-
E
L
A
-
S
Q
P
V
R
Q
F
-----------
D
R
Y
F
--
Q
S
L
N
-------------
P
---------
Y
N
N
H
R
N
P
W
F
R
D
F
W
E
Q
K
F
Q-----
C
S
LQ-------
R
V
C
D
K
H
L
A
I
D
S
S
N
Y
E
--
Q
E
S
K
I
M
F
-
V
V
----------
N
A
V
Y
A
M
A
H
A
L
----
H
--
K
M
Q
R
T
L
C
PNTTK
L
C
--
D
----
A
----
M
--
K
----
I
L
D
-
G
-
K
K
-
L
Y
K
D
Y
-
L
-
L
K
I
-
N
F
T
A
P
F
N
-------
P
--------------DS
I
V
K
F
D
T
F
G
------------
D
G
M
G
R
Y
N
V
F
N
F
Q
-
N
-
V
G
G
K
Y
S
Y
L
K
V
G
H
--
W
A
E
T
-
L
S
L
D
V
N
S
I
H
W
--
S
R
N
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
80.58
25%
-91
- C1 -
3LMK
4
GRM5_HUMAN
A:
[12-482]
---------------------------
R
R
V
V
A
H
M
P
G
D
I
I
I
G
A
L
F
S
V
H
-------
H
Q
P
T
V
D
K
V
H
E
R
K
C
G
--
A
V
R
E
-
Q
-
Y
G
I
Q
R
V
E
A
M
L
H
T
L
E
R
I
N
S
D
P
T
L
L
P
N
I
T
L
G
C
E
I
R
D
S
C
W
H
S
A
-
V
A
L
E
Q
S
I
E
F
I
R
D
------------------------
K
-
P
I
V
G
V
I
G
P
G
S
S
S
V
A
I
Q
V
Q
N
L
L
Q
L
F
N
I
P
Q
I
A
Y
S
A
T
S
M
D
L
S
D
K
T
L
F
K
Y
F
M
R
V
V
P
S
D
A
Q
Q
A
R
A
M
V
D
I
V
K
R
Y
N
W
T
Y
V
S
A
V
H
T
E
G
N
Y
G
E
S
G
M
E
A
F
K
D
-
M
S
A
K
E
G
I
S
I
A
H
S
Y
K
I
Y
S
N
A
G
E
Q
S
F
D
K
L
L
K
----
K
L
T
S
H
L
P
-
K
----
A
R
V
V
A
C
F
C
E
G
M
T
V
R
G
L
L
M
A
M
R
R
L
G
L
A
G
E
F
L
-
L
L
G
S
D
G
W
A
D
R
Y
D
V
T
--
D
G
Y
Q
R
E
A
-
V
G
G
-
I
T
I
K
-
L
Q
S
--
P
D
V
K
W
F
-----------
D
D
Y
Y
--
L
---
K
-
L
---------
R
P
---------
E
T
N
H
R
N
P
W
F
Q
E
F
W
Q
H
R
F
QCRLEG---------
N
-
K
T
C
N
S
S
L
T
L
K
T
H
H
V
Q
D
S
K
M
G
F
V
I
N
--------------
A
I
Y
S
M
A
Y
G
L
----
H
N
M
Q
M
----------
S
L
--
C
----
P
GY--
A
--
G
----
L
C
D
-
A
-
M
K
P
I
D
G
R
K
-
L
-
L
E
S
-
L
M
K
T
N
F
T
G
------
V
S
--
G
-
D
-------
T
---
I
L
F
D
E
N
G
------------
D
S
P
G
R
Y
E
I
M
N
F
K
-
E
-
M
G
K
D
Y
-
F
D
Y
I
N
V
G
S
W
D
N
G
E
L
K
M
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
76.08
25%
-100
- C1 -
3SM9
8
GRM3_HUMAN
A:
[5-475]
----------------------------
R
R
E
I
K
I
E
G
D
L
V
L
G
G
L
F
P
I
N
E
K
G
T
-------
T
-
E
E
C
G
---
R
--
I
--
N
E
D
-
R
G
I
Q
R
L
E
A
M
L
F
A
I
D
E
I
N
K
D
D
Y
L
L
P
G
V
K
L
G
V
H
I
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
----
L
E
F
V
R
A
-----
S
---------------
L
-
L
I
A
G
V
I
G
G
S
Y
S
S
V
S
I
Q
V
A
N
L
L
R
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
I
L
R
F
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
F
E
Q
-
E
A
R
L
R
N
I
S
I
A
--
T
A
E
K
V
G
R
--
I
--
R
K
S
Y
D
----
S
V
I
R
E
L
L
Q
K
P
-
N
-
A
R
V
V
V
L
F
M
R
S
D
D
S
R
E
L
I
A
A
A
S
R
A
N
A
-
S
F
-
T
-
W
V
A
S
D
G
W
G
A
Q
E
S
I
I
K
G
-
S
E
H
V
A
Y
G
A
I
T
-
L
E
L
A
-
S
Q
P
-
V
R
Q
F
D
R
Y
-----------
F
Q
S
L
--
N
P
Y
N
N
H
R
NPW
F
R
D
F
W
E
Q
K
---------
F
Q
C
S
L
Q
N
---------------------
H
R
R
V
C
-
D
K
H
L
A
I
D
S
S
N
-----
Y
E
Q
E
S
K
I
M
F
-
V
V
----------
N
A
V
Y
A
M
A
H
A
L
----
H
--
K
M
----------
Q
R
--
T
----
L
----
C
--
P
NTTK
L
C
D
A
M
-
K
I
-
L
D
G
K
K
L
Y
-
K
D
Y
-
L
L
K
I
N
F
T
-------
A
P
FN
D
-
S
-------
I
---
V
K
F
D
T
F
G
------------
D
G
M
G
R
Y
N
V
F
N
F
Q
-
N
-
V
G
G
K
Y
S
Y
L
K
V
G
H
W
A
E
T
L
S
---
L
D
V
N
S
I
H
W
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
72.27
24%
-92
- C1 -
1EWK
5
GRM1_RAT
A:
[9-480]
---------------------------------
M
D
G
D
V
I
I
G
A
L
F
S
V
H
------
H
Q
P
P
A
E
-
K
V
P
E
R
K
C
G
E
I
R
--
E
-
Q
-
Y
G
I
Q
R
V
E
A
M
F
H
T
L
D
K
I
N
A
D
P
V
L
L
P
N
I
T
L
G
S
E
I
R
D
S
C
W
H
S
S
-
V
A
L
E
Q
----
S
I
E
F
I
R
---------------------
K
-
P
I
A
G
V
I
G
P
G
S
S
S
V
A
I
Q
V
Q
N
L
L
Q
L
F
D
I
P
Q
I
A
Y
S
A
T
S
I
D
L
S
D
K
T
L
Y
K
Y
F
L
R
V
V
P
S
D
T
L
Q
A
R
A
M
L
D
I
V
K
R
Y
N
W
T
Y
V
S
A
V
H
T
E
G
N
Y
G
E
S
G
M
D
A
F
K
E
-
L
A
A
Q
E
G
L
C
I
A
--
H
S
D
K
I
Y
S
N
A
G
E
K
S
F
D
R
L
----
L
R
K
L
R
E
R
-
L
P
-
K
-
A
R
V
V
V
C
F
C
E
G
M
T
V
R
G
L
L
S
A
M
R
R
L
G
V
V
G
E
-
F
S
L
I
G
S
D
G
W
A
D
R
D
E
V
I
E
G
Y
E
V
E
A
N
G
---
G
-
I
T
I
K
-
L
Q
S
--
P
E
V
R
S
F
-----------
D
D
Y
F
L
K
L
R
L
D
T
-
N
---------
T
R
---------
N
P
W
F
P
E
F
W
---------------
Q
H
---
R
F
Q
-
C
-
R
L
P
G
H
L
L
E
N
P
N
F
K
K
V
C
T
G
N
E
S
L
E
E
-
N
Y
VQDSK
M
G
F
V
I
N
A
I
Y
A
M
A
H
G
L
Q
N
M
H
H
--
A
L
----------
C
P
--
G
----
H
----
V
--
G
----
L
C
D
-
A
-
M
K
P
I
D
G
R
K
-
L
-
L
D
F
-
L
I
K
S
S
F
V
G
------
V
S
--
G
-
E
-------
E
---
V
W
F
D
E
K
G
------------
D
A
P
G
R
Y
D
I
M
N
L
Q
-
Y
T
E
A
N
R
Y
D
Y
V
H
V
G
--
T
W
H
E
G
V
L
N
I
D
D
Y
K
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
71.25
24%
-95
- C1 -
1EWT
2
GRM1_RAT
A:
[9-480]
---------------------------------
M
D
G
D
V
I
I
G
A
L
F
S
V
H
------
H
Q
P
P
A
E
-
K
V
P
E
R
K
C
G
E
I
R
--
E
-
Q
-
Y
G
I
Q
R
V
E
A
M
F
H
T
L
D
K
I
N
A
D
P
V
L
L
P
N
I
T
L
G
S
E
I
R
D
S
C
W
H
S
S
-
V
A
L
E
Q
----
S
I
E
F
I
R
-----
D
S
L
I
S
I
R
---------
K
-
P
I
A
G
V
I
G
P
G
S
S
S
V
A
I
Q
V
Q
N
L
L
Q
L
F
D
I
P
Q
I
A
Y
S
A
T
S
I
D
L
S
D
K
T
L
Y
K
Y
F
L
R
V
V
P
S
D
T
L
Q
A
R
A
M
L
D
I
V
K
R
Y
N
W
T
Y
V
S
A
V
H
T
E
G
N
Y
G
E
S
G
M
D
A
F
K
E
-
L
A
A
Q
E
G
L
C
I
A
--
H
S
D
K
I
Y
S
N
A
G
E
K
S
F
D
R
L
----
L
R
K
L
R
E
R
-
L
P
-
K
-
A
R
V
V
V
C
F
C
E
G
M
T
V
R
G
L
L
S
A
M
R
R
L
G
V
V
G
E
-
F
S
L
I
G
S
D
G
W
A
D
R
D
E
V
I
E
G
Y
E
V
E
A
N
G
---
G
-
I
T
I
K
-
L
Q
S
--
P
E
V
R
S
F
-----------
D
D
Y
F
L
K
L
R
L
D
T
-
N
---------
T
R
---------
N
P
W
F
P
E
F
W
---------------
Q
H
---
R
F
Q
-
C
-
R
L
P
G
H
L
L
E
N
P
N
F
K
K
V
C
T
G
N
E
S
L
E
E
-
N
Y
VQDSK
M
G
F
V
I
N
A
I
Y
A
M
A
H
G
L
Q
N
M
H
H
--
A
L
----------
C
P
--
G
----
H
----
V
--
G
----
L
C
D
-
A
-
M
K
P
I
D
G
R
K
-
L
-
L
D
F
-
L
I
K
S
S
F
V
G------
V
S
--
G
-
E
-------
E
---
V
W
F
D
E
K
G
------------
D
A
P
G
R
Y
D
I
M
N
L
Q
-
Y
T
E
A
N
R
Y
D
Y
V
H
V
G
--
T
W
H
E
G
V
L
N
I
D
D
Y
K
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
70.77
24%
-94
- C1 -
1ISS
1
GRM1_RAT
A:
[9-480]
---------------------------------
M
D
G
D
V
I
I
G
A
L
F
S
V
H
------
H
Q
P
P
A
E
-
K
V
P
E
R
K
C
G
EI
R
--
E
-
Q
-
Y
G
I
Q
R
V
E
A
M
F
H
T
L
D
K
I
N
A
D
P
V
L
L
P
N
I
T
L
G
S
E
I
R
D
S
C
W
H
S
S
-
V
A
L
E
Q
----
S
I
E
F
I
R
-----
D
S
L
I
------------
K
-
P
I
A
G
V
I
G
P
G
S
S
S
V
A
I
Q
V
Q
N
L
L
Q
L
F
D
I
P
Q
I
A
Y
S
A
T
S
I
D
L
S
D
K
T
L
Y
K
Y
F
L
R
V
V
P
S
D
T
L
Q
A
R
A
M
L
D
I
V
K
R
Y
N
W
T
Y
V
S
A
V
H
T
E
G
N
Y
G
E
S
G
M
D
A
F
K
E
-
L
A
A
Q
E
G
L
C
I
A
--
H
S
D
K
I
Y
S
N
A
G
E
K
S
F
D
R
L
----
L
R
K
L
R
E
R
-
L
P
-
K
-
A
R
V
V
V
C
F
C
E
G
M
T
V
R
G
L
L
S
A
M
R
R
L
G
V
V
G
E
-
F
S
L
I
G
S
D
G
W
A
D
R
D
E
V
I
E
G
Y
E
V
E
A
N
G
---
G
-
I
T
I
K
-
L
Q
S
--
P
E
V
R
S
F
-----------
D
D
Y
F
L
K
L
R
L
D
T
-
N
---------
T
R
---------
N
P
W
F
P
E
F
W
---------------
Q
H
---
R
F
Q
-
C
-
R
L
P
G
H
L
L
E
N
P
N
F
K
K
V
C
T
G
N
E
S
L
E
E
-
N
Y
VQDSK
M
G
F
V
I
N
A
I
Y
A
M
A
H
G
L
Q
N
M
H
H
--
A
L
----------
C
P
--
G
----
H
----
V
--
G
----
L
C
D
-
A
-
M
K
P
I
D
G
R
K
-
L
-
L
D
F
-
L
I
K
S
S
F
V
G
------
V
S
--
G
-
E
-------
E
---
V
W
F
D
E
K
G
------------
D
A
P
G
R
Y
D
I
M
N
L
Q
-
Y
T
E
A
N
R
Y
D
Y
V
H
V
G
--
T
W
H
E
G
V
L
N
I
D
D
Y
K
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
70.64
24%
-90
- C1 -
1ISR
3
GRM1_RAT
A:
[9-480]
---------------------------------
M
D
G
D
V
I
I
G
A
L
F
S
V
H
------
H
Q
P
P
A
E
-
K
V
P
E
R
K
C
G
E
I
R
--
E
-
Q
-
Y
G
I
Q
R
V
E
A
M
F
H
T
L
D
K
I
N
A
D
P
V
L
L
P
N
I
T
L
G
S
E
I
R
D
S
C
W
H
S
S
-
V
A
L
E
Q
----
S
I
E
F
I
R
---------------------
K
-
P
I
A
G
V
I
G
P
G
S
S
S
V
A
I
Q
V
Q
N
L
L
Q
L
F
D
I
P
Q
I
A
Y
S
A
T
S
I
D
L
S
D
K
T
L
Y
K
Y
F
L
R
V
V
P
S
D
T
L
Q
A
R
A
M
L
D
I
V
K
R
Y
N
W
T
Y
V
S
A
V
H
T
E
G
N
Y
G
E
S
G
M
D
A
F
K
E
-
L
A
A
Q
E
G
L
C
I
A
--
H
S
D
K
I
Y
S
N
A
G
E
K
S
F
D
R
L
----
L
R
K
L
R
E
R
-
L
P
-
K
-
A
R
V
V
V
C
F
C
E
G
M
T
V
R
G
L
L
S
A
M
R
R
L
G
V
V
G
E
-
F
S
L
I
G
S
D
G
W
A
D
R
D
E
V
I
E
G
Y
E
V
E
A
N
G
---
G
-
I
T
I
K
-
L
Q
S
--
P
E
V
R
S
F
-----------
D
D
Y
F
L
K
L
R
L
D
T
-
N
---------
T
R
---------
N
P
W
F
P
E
F
W
---------------
Q
H
---
R
F
Q
-
C
-
R
L
P
G
H
L
L
E
N
P
N
F
K
K
V
C
T
G
N
E
S
L
E
E
-
N
Y
VQDSK
M
G
F
V
I
N
A
I
Y
A
M
A
H
G
L
Q
N
M
H
H
--
A
L
----------
C
P
--
G
----
H
----
V
--
G
----
L
C
D
-
A
-
M
K
P
I
D
G
R
K
-
L
-
L
D
F
-
L
I
K
S
S
F
V
G
------
V
S
--
G
-
E
-------
E
---
V
W
F
D
E
K
G
------------
D
A
P
G
R
Y
D
I
M
N
L
Q
-
Y
T
E
A
N
R
Y
D
Y
V
H
V
G
--
T
W
H
E
G
V
L
N
I
D
D
Y
K
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
Fugue
70.58
23%
-86
- C1 -
1EWK
5
GRM1_RAT
A:
[4-480]
----------------------------
R
S
V
A
R
M
D
G
D
V
I
I
G
A
L
F
S
V
H
H
Q
P
P
A
E
K
V
P
E
R
-----
K
C
G
E
I
--
R
--
E
-
Q
-
Y
G
I
Q
R
V
E
A
M
F
H
T
L
D
K
I
N
A
D
P
V
L
L
P
N
I
T
L
G
S
E
I
R
D
S
C
W
H
S
S
-
V
A
L
E
Q
----
S
I
E
F
I
---------------------
R
K
-
P
I
A
G
V
I
G
P
G
S
S
S
V
A
I
Q
V
Q
N
L
L
Q
L
F
D
I
P
Q
I
A
Y
S
A
T
S
I
D
L
S
D
K
T
L
Y
K
Y
F
L
R
V
V
P
S
D
T
L
Q
A
R
A
M
L
D
I
V
K
R
Y
N
W
T
Y
V
S
A
V
H
T
E
G
N
Y
G
E
S
G
M
D
A
F
K
E
-
L
A
A
Q
E
G
L
C
I
A
--
H
S
D
K
I
Y
S
N
A
G
E
K
S
F
D
R
L
----
L
R
K
L
R
E
R
-
L
P
-
K
-
A
R
V
V
V
C
F
C
E
G
M
T
V
R
G
L
L
S
A
M
R
R
L
G
V
V
G
E
F
S
-
L
I
G
S
D
G
W
A
D
R
D
E
V
I
E
G
Y
E
V
E
A
N
G
-
G
I
T
-
I
K
L
Q
-
S
P
E
-
V
R
S
F
D
D
Y
F
L
K
LRLDTNTR
N
P
W
F
--
P
E
F
W
Q
-
H
---------
R
F
---------
Q
C
R
L
P
G
H
L
---------------
L
E
---
N
P
N
F
K
-
K
V
C
T
G
---
N
E
S
L
E
E
N
Y
V
Q
D
S
K
M
G
F
-
V
I
----------
N
A
I
Y
A
M
A
H
G
L
----
Q
--
N
M
----------
H
H
--
A
----
L
CPGH
V
--
G
----
L
C
D
-
A
M
K
P
-
I
D
G
R
K
-
L
-
L
D
F
-
L
I
K
S
S
F
V
-------
G
V
--
S
G
E
-------
E
---
V
W
F
D
E
K
G
------------
D
A
P
G
R
Y
D
I
M
N
L
Q
-
Y
-
T
-
E
A
N
R
Y
D
Y
V
H
V
G
T
W
H
E
G
V
L
N
I
D
D
Y
K
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
69.29
24%
-93
- C1 -
1EWV
-
GRM1_RAT
A:
[41-512]
---------------------------------
M
D
G
D
V
I
I
G
A
L
F
S
V
H
------
H
Q
P
P
A
E
-
K
V
P
E
R
K
C
G
E
I
R
--
E
-
Q
-
Y
G
I
Q
R
V
E
A
M
F
H
T
L
D
K
I
N
A
D
P
V
L
L
P
N
I
T
L
G
S
E
I
R
D
S
C
W
H
S
S
-
V
A
L
E
Q
----
S
I
E
F
I
R
---------------------
K
-
P
I
A
G
V
I
G
P
G
S
S
S
V
A
I
Q
V
Q
N
L
L
Q
L
F
D
I
P
Q
I
A
Y
S
A
T
S
I
D
L
S
D
K
T
L
Y
K
Y
F
L
R
V
V
P
S
D
T
L
Q
A
R
A
M
L
D
I
V
K
R
Y
N
W
T
Y
V
S
A
V
H
T
E
G
N
Y
G
E
S
G
M
D
A
F
K
E
-
L
A
A
Q
E
G
L
C
I
A
--
H
S
D
K
I
Y
S
N
A
G
E
K
S
F
D
R
L
----
L
R
K
L
R
E
R
-
L
P
-
K
-
A
R
V
V
V
C
F
C
E
G
M
T
V
R
G
L
L
S
A
M
R
R
L
G
V
V
G
E
-
F
S
L
I
G
S
D
G
W
A
D
R
D
E
V
I
E
G
Y
E
V
E
A
N
G
---
G
-
I
T
I
K
-
L
Q
S
--
P
E
V
R
S
F
-----------
D
D
Y
F
L
K
L
R
L
D
T
-
N
---------
T
R
---------
N
P
W
F
P
E
F
W
---------------
Q
H
---
R
F
Q
-
C
-
R
L
P
G
H
L
L
E
N
P
N
F
K
K
V
C
T
G
N
E
S
L
E
E
-
N
Y
VQDSK
M
G
F
V
I
N
A
I
Y
A
M
A
H
G
L
Q
N
M
H
H
--
A
L
----------
C
P
--
G
----
H
----
V
--
G
----
L
C
D
-
A
-
M
K
P
I
D
G
R
K
-
L
-
L
D
F
-
L
I
K
S
S
F
V
G
------
V
S
--
G
-
E
-------
E
---
V
W
F
D
E
K
G
------------
D
A
P
G
R
Y
D
I
M
N
L
Q
-
Y
T
E
A
N
R
Y
D
Y
V
H
V
G
--
T
W
H
E
G
V
L
N
I
D
D
Y
K
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------